Sequencing

How scientists use various sequencing technologies to answer the most challenging questions

When we studied how labs large and small utilize sequencing in their research we found just one thing in common: they all do it differently. The reality is, it usually takes a wide range of solutions to discover, validate and produce actionable results.

Data considerations for Human Genome Sequencing: Is Smaller Better?

Data analysis and data management are two areas that tend to get overlooked in the decision making process of which sequencing approach to choose.

As our knowledge of the genetics implicated in disease increases, the requirements to use a broad net to detect mutations in a limited sub set of genes reduces and gene panels will become the way forward as it will reduce the cost and data management burden.

Figure 1. CE and NGS techniques for research and applied markets.  Click image to enlarge

Choose Sanger sequencing to:

• Study a small subset of genes linked to a defined phenotype
• Confirm NGS variants
• Detect minor allele fractions down to 5%
• Read contiguous sequences up to 1000 bases

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Choose NGS to:

• Study diseases with higher levels of phenotypic heterogeneity
• Make unbiased queries of a large number of genes to discover novel variants
• Sequence up to 260 million reads per day
  
  

New to sequencing?

No matter which sequencing instrument you choose, we offer optimized reagents and consumables, intuitive analysis software, and world-class technical support.

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• Oncology
• Inherited disease
• Microbial

See all applications ›

• Next-generation sequencing
• Sanger sequencing
• Fragment analysis