Whatever awaits… there’s a GC Orbitrap for that!

• Resolving power of up to 240,000 (FWHM) at m/z 200 for the Orbitrap Exploris GC 240 mass spectrometer. Orbitrap Exploris GC mass spectrometer at up to 60,000.
  • Allows you to separate compounds of interest from chemical background
  • Can consolidate multiple methods on one platform with highly selective full scan
• Routine sub-ppm mass accuracy
  • Increases confidence in your determinations
  • Eliminates the need to mass calibrate multiple times per day
• < 6 fg OFN Instrument Detection Limit
  • Maximum sensitivity at all resolving power levels for the ability to detect and quantify compounds in full scan acquisition
• EI/CI Thermo Scientific Extractabrite ion source removable under vacuum through vacuum interlock (standard on both the Orbitrap Exploris GC and Orbitrap Exploris GC 240 mass spectrometers)
  • CI allows molecular ion to be identified
  • Can propose identity of compounds not in existing spectral libraries
• Vent-free column exchange with NeverVent technology
  • Replace or maintain a column or switch applications without having to vent the system, which saves time (no bake out required)
• Advanced Quadrupole Technology (AQT) for superior precursor isolation
  • Improves sensitivity by delivering a focused ion beam to the detector
• Variable electron voltage (VeV) technology for softer EI to promote molecular ion

What if you could have additional points of confirmation? The high-resolution full-scan acquisition provided by the GC Orbitrap MS systems provides greater confidence that you aren’t missing critical sample components.

There is a GC Orbitrap for…

• Quickly increasing your scope of analysis with highly selective full-scan acquisition
• Accurate quantitation across six orders of magnitude
• Eliminating the “maybe there” peaks through additional points of confirmation

High selectivity full-scan analysis brings new possibilities for routine contaminant detection and food research: ease of analytical set-up, almost unlimited scope, efficient automatic data processing and retrospective data analysis. The Orbitrap Exploris GC mass spectrometer has the quantitative power of a GC triple quadrupole MS combined with the full-scan high-resolution, accurate-mass (HRAM) capability that only Orbitrap GC-MS technology can offer. This combination will improve lab productivity – forever.

What if you could understand your samples better than ever before so your products could be better and safer than ever before? The sensitivity and high resolution of Orbitrap-based GC-MS systems and powerful yet easy-to-use software make this a reality.

There is a GC Orbitrap for…

• Providing the right answer first time when an unknown contaminant is suspected
• Flexible inlet options including direct analysis probes
• Fast change of column and source configuration through vacuum probe interlock

Whether you need to ensure final products being shipped meet quality control standards, develop new products, or identify a suspect contaminant, an Orbitrap-based GC-MS system will give you a comprehensive profile of your sample. The unrivalled combination of high-resolution gas chromatography separations and highly sensitive HRAM acquisitions combined with intelligent identification software will help unlock answers to questions about the very nature of each sample you inject.

The flexibility to change quickly between EI and chemical ionization (CI) will provide further information and/or confirmations of compounds detected. Positive chemical ionization (PCI) can be used to yield molecular ions. These ions can be measured directly in the Orbitrap GC-MS system or after fragmentation in the HCD for further HRAM investigation into the compound structure.

What if you could measure known impurities in your samples while simultaneously identifying new ones that could render your products unsafe? And what if you could do that in a single run? You can with the unparalleled mass accuracy and dynamic detection range of an HRAM Orbitrap GC-MS system.

There is a GC Orbitrap for…

• Providing a comprehensive profile of your sample
• Structural elucidation of new and unknown compounds
• Detailed extractable and leachable studies

The investigation of potentially toxic chemicals leaching from packaging products or the detection of pharmaceutical impurities is a challenging analysis with compounds present at both ultra-trace and high concentrations in a complex sample. The Orbitrap Exploris GC or Orbitrap Exploris GC 240 mass spectrometers with a dynamic range across six orders, sub-ppm mass accuracy, and the ability to use liquid, headspace, and direct analysis probes makes this analytical platform essential for pharmaceutical research and development.

The challenges of nitrosamine analysis in pharmaceuticals relate to sensitivity, selectivity, and compliance all in the light of obtaining reliable and timely results. High sensitivity must be achieved to fulfill the regulation requirements and selectivity is critical to avoid false positive non-compliant results. Pharmaceutical manufacturers also must assess their products for any condition that might potentially lead to nitrosamine formation. Although quantification of known compounds is essential, screening for unknown precursor chemicals that may contribute to the formation of nitrosamines is equally important. For this, Orbitrap GC-MS systems combine quantitative and qualitative strengths in a single platform, allowing for targeted and untargeted screening of impurities and a deeper characterization of samples.