Anti-HLA Antibodies and Immune Responses. Back to Basics Series, Episode 4

Anti-HLA Antibodies and Immune Responses, Episode 4


This is the fourth episode of our foundational series, Back to Basics. This episode describes antibodies and possible immune responses against HLA proteins. We will describe antibody function, morphology, and development, and specific concepts relevant to anti-HLA antibodies including PRA, DSA, cross-reactive groups (CREGs), epitopes, eplets, and interfering factors. Finally, we will describe the effects of antibody-mediated and cellular immune responses that may occur in both solid organ and bone marrow/stem cell transplantation.
 

Instructor:
Linda Olsen, MPH, CHS(ACHI), MLS(ASCP)CM,
Sr. Technical Training Specialist – Molecular, Thermo Fisher Scientific

HLA Fundamentals: Back to Basics⠀⠀ ⠀⠀ ⠀⠀ ⠀

Meet the speaker

Linda serves as Technical Training Specialist for our molecular products, a role she has held since March 2022. She holds a bachelor’s degree in clinical laboratory science and a master’s in public health policy and management. She has worked in HLA since 2008, with experience at the University of Utah, Stanford, and ClinImmune Labs. Prior to joining the Technical Training team, she was supervisor of the HLA lab at Mayo Clinic Arizona. She has also served as an ASHI inspector and committee member. She enjoys teaching and increasing access to educational materials on the science and application of HLA.

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