A pyramidal neuron from rat hippocampus was first exposed to Alzheimer’s ß-amyloid peptide and then to the excitatory amino acid glutamate.

A pyramidal neuron from rat hippocampus was first exposed to Alzheimer’s ß-amyloid peptide and then to the excitatory amino acid glutamate. Confocal laser-scanning microscopy imaging using the intracellular Ca2+ indicator fluo-3 (Cat. no. F1241, F1242, F14218, F14242, F23915) shows that ß-amyloid peptide destabilizes the neuron’s calcium homeostasis and increases its vulnerability to excitotoxicity. The image was contributed by Mark P. Mattson, Sanders-Brown Center on Aging, University of Kentucky.

A pyramidal neuron from rat hippocampus was first exposed to Alzheimer’s ß-amyloid peptide and then to the excitatory amino acid glutamate. Confocal laser-scanning microscopy imaging using the intracellular Ca2+ indicator fluo-3 (Cat. no. F1241, F1242, F14218, F14242, F23915) shows that ß-amyloid peptide destabilizes the neuron’s calcium homeostasis and increases its vulnerability to excitotoxicity. The image was contributed by Mark P. Mattson, Sanders-Brown Center on Aging, University of Kentucky.

Related Products

Related Images

REF-52 fibroblasts. Cyclic AMP Fluorosensor (FlCRhR) and fura-2 AM Go ›

Pseudocolored images of changes in intracellular free Ca2+ in AtT-20/D16v-F2 cells, monitored at 9 sec intervals with fluo-4, AM (F14201, F14202, F14217, F23917). Go ›

Developing Drosophila embryo Go ›

Cytoskeleton of a mixed population of granule neurons and glial cells Go ›

Live cell imaging with CellLight™ reagents. Go ›

Live cells transduced with Organelle Lights™ or Cellular Lights™ reagents. Go ›

CD335 (NKp46) Antibody (63335182) in RE Go ›

CD223 (LAG-3) Antibody (56223942) in TM Go ›