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Innovative Solutions for
Every Stage of Therapeutic
Antibody Development
Reliable solutions for every stage of therapeutic antibody development
In your efforts to discover, synthesize, characterize, and optimize antibody candidates, you need reliability. When you’re ready to scale up your manufacturing, you need consistency. We offer reliable, consistent, and innovative solutions for every stage of therapeutic antibody development, to help you ensure the quality and safety of your biologics.
From protein expression systems and immunoassays to bioreactors and plastics, we provide high performing reagents and full-process universal equipment and consumables to effectively minimize cross-contamination and maintain environmental stability. To help you ensure that a recombinant antibody is safe, effective, and accepted by regulatory authorities, we’re here for you with outstanding QA/QC services.
View our comprehensive list of products, services, and technologies to support you at every step of the therapeutic antibody development process.
Target discovery
Research into the biology and progression of a disease allows the identification and validation of druggable disease targets and their suitability for targeting with monoclonal antibody therapies.
Quick links: Genetic analysis | Protein analysis | Cell-based analysis | Commercialization solutions | Resources
Featured product
Silencer Select siRNA libraries
Highly potent and specific siRNAs covering human pre-defined gene families and pathways, including the druggable genome
TaqMan real-time PCR assays
96- or 384-well plate based pre-spotted with dried-down Applied Biosystems TaqMan Gene Expression Assays delivers results in only 30–45 min
ProcartaPlex immunoassays
Multiplex protein quantitation using the Luminex instrument platform, covering >300 cytokines, chemokines, growth factors, and other protein targets
TSX Series ultra-low freezers
Designed with features that support sustainability objectives without compromising performance
Immune repertoire with NGS
A rapid, long-read NGS tool for analyzing the immune repertoire to capture the diversity of T cell receptor (TCR) rearrangements.
Gene expression analysis using qPCR
Best-coverage assays to detect the highest number of transcript variants possible, with gold-standard specificity, sensitivity, and reproducibility.
Gene knockout using CRISPR-Cas9
Advanced gRNA designs for maximum efficiency without sacrificing specificity; arrayed libraries in flexible formats for a wide variety of assays.
Gene knockdown using siRNAs
Potent and specific siRNAs covering the druggable genome, with proprietary algorithm and chemical modifications.
Gene expression analysis using RNA sequencing
From targeted gene expression analysis to whole-transcriptome sequencing, combine simple sample preparation and intuitive data analysis.
Mass spectrometry
Understand the functions of individual proteins and their place in complex biological systems with state-of-the-art proteomics mass spectrometry.
Immunoassays
Investigate protein and RNA biomarkers in key disease research areas from single-analyte analysis using ELISA formats to multiplex bead-based assays.
Protein–protein interaction assays
Characterize protein interactions through methods such as immunoprecipitation, yeast two-hybrid screening, phage display, and more.
Protein structure analysis by cryo-electron microscopy
Generate complete structural information, uncover how antibodies function in the body, and show how they bind to antigens.
pH measurements
Make your pH measurements of your buffers and reagents fast and reliable with an extensive range of meters, electrodes and accessories designed to work seamlessly together.
Regulatory T cells (Treg) analysis
Understand the role of regulatory T cells with reagents for expansion, differentiation and functional studies, and cytokine profiling.
Cell function assays
A broad range of cell function and behavior assays and reagents that can be used on multiple instrument platforms.
Cell model creation
Closely mimic the in vivo state and generate more physiologically relevant data with complete cell culture systems for mAb discovery.
Immune response analysis by flow cytometry
Simultaneously analyze multiple proteins, gene expression, and cell functions such as oxidation, viability, cell cycle, apoptosis, and proliferation.
Biological safety cabinets
Maximise sample protection and user safety, with an emphasis on containment, comfort and convenience, all day, every day.
Antibody generation and engineering
Generate antibodies that bind to the target, then engineer to improve performance e.g., chimerization, humanization, manufacture of recombinant antibody fragments, bispecific antibodies, and antibody drug conjugates.
Featured product
GeneArt Gene Synthesis and Protein Services
Reliable and cost-effective method for obtaining customized DNA constructs with 100% sequence accuracy.
Custom peptide synthesis
Numerous options for synthesis platforms, purity levels, modifications, and formats to meet a variety of research needs.
Finnpipet F1 Pipettes
Improve accuracy and precision with pipetting systems that incorporate years of experience and innovation for consistent, reproducible results.
Gene synthesis for expression-ready genes
Preparation of optimized synthetic, expression-ready genes for stable and increased protein expression or DNA immunization.
Transient protein expression system
Rapidly produce high amounts of protein with integrated expression system solutions that give yield, speed, and cost benefits.
Custom peptide synthesis services
Peptides synthesized using the latest FMOC solid-phase technology, and purified using HPLC.
Carrier protein immunogens and adjuvants
Immunization adjuvants are used to increase or stimulate immune response when mixed and injected with prepared immunogens.
Serum-free hybridoma media
Chemically defined, protein-free formulation designed for maximum performance.
Transient protein expression platforms
High-density, serum-free suspension culture and specially designed transfection reagents for the highest yields possible in a transient system.
Phage display systems
High-quality magnetic beads with increased surface area for panning saturated phage solutions during phage display.
High-content screening
Platforms and software for cutting-edge images and high content imaging data in no time; exceptional resolution with subcellular, automated detection.
CO2 incubators
You can achieve your goals faster, more reliably and with less effort, with our technology advancements in contamination control and uniform growth conditions.
Gene synthesis for antibody DNA variant libraries
Create proteins with characteristics you need for affinity maturation; significantly reduce screening efforts compared to conventional mutagenesis.
Antibody characterization
The evaluation of biological and molecular/structural characteristics during development and production. Multi-attribute methods based on a combination of peptide mapping and mass spectroscopy are increasingly being used.
Featured product
CellInsight CX7 LZR Pro HCS Platform
A fast, laser-based, automated cellular imaging and analysis platform for quantitative microscopy and phenotypic screening.
EVOS M7000 Imaging System
High-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system.
Attune Flow Cytometers
Compact, benchtop cell analyser that can be configured with up to four spatially separated lasers to flexibly design, run, and analyse panels of up to 14 colors.
Barnstead Type 1 Water Purification
Deliver type 1 ultrapure water straight from your tap and benefit from easy-to-use configurations and lasting economy.
Immunoassays
Matched antibody pairs, uncoated and coated-plate ELISA kits, and multiplexing assays for reliability and specificity during ligand binding studies.
Cell function assays
Cell-based assays and reagents for key cellular processes, including apoptosis, cell proliferation, cell cycle and viability.
Biodistribution assays
A range of products for imaging biological processes in live animals to understand cellular activity, effects of drugs, and disease progression.
Immune response analysis by flow cytometry
Simultaneously analyze multiple proteins, gene expression, and cell functions such as oxidation, viability, cell cycle, apoptosis, and proliferation.
Automated reagent dispensing
A new workflow solution to increase throughput, reproducibility, and speed through automated reagent dispensing into a wide selection of plate and volume ranges.
Protein or peptide quantitation
A broad range of protein or peptide quantitation assays for your sample type and application.
Size heterogeneity analysis
SEC HPLC columns for monoclonal antibody, aggregate, and fractions separation.
Peptide mapping
A unique combination of innovative technologies in a start-to-finish workflow that is designed to be fast, reliable, reproducible, and easy to use.
Protein structure analysis with mass spectrometry
Obtain maximum insights on your most complex molecules and biological systems, from whole-proteome profiling and quantitation, structural characterization to multiplexed single-cell proteomics.
Charge variant analysis
A range of buffers, ion exchange or hydrophobic interaction column chemistries, and UHPLC instrumentation to meet the needs for robust analysis of charge variants in monoclonal antibodies.
Bioproduction and process development
Production of antibodies for clinical trials may include the use of alternative expression systems, continuous biomanufacturing systems, and non-chromatographic separation formats.
Featured product
Media manufacturing services
We are committed to meeting your toughest challenges with high-performing Gibco products and services customized to your research and production needs.
Single-use bioprocessing
Our proven, scalable technologies include bioprocessing equipment and automation, and flexible and rigid containment.
cGMP custom manufacturing
Take advantage of our fully validated cGMP media manufacturing services when you are ready for full-scale production.
Nalgene packaging bottles
Providing the most comprehensive range or customizable packaging solutions to protect your high-value liquids.
Stable cell line development
Integrated stable cell line development solutions to simplify your development workflow and accelerate your processes to commercial manufacture.
Cell culture media development and optimization
Optimize your media and processes for increased titers, quality, and manufacturability with our media development services.
Bioreactor systems
Scalability from research to cGMP manufacturing with a comprehensive bioreactor portfolio.
CO2 incubators
You can achieve your goals faster, more reliably and with less effort, with our technology advancements in contamination control and uniform growth conditions.
Affinity chromatography resins
Resins designed specifically for the purification of antibody fragments and novel antibody formats.
Bioprocess resins
For large scale manufacturing of biopharmaceuticals, high-performance and high-throughout resins.
Hydrophobic interaction chromatography
A suite of resins suitable for bind/elute and flow-through applications; purify a wide variety of biomolecules at low salt concentrations.
Residual host-cell DNA quantitation
Complete solution for extraction and quantitation of DNA from biopharmaceutical purification sample matrices.
Mycoplasma detection testing
Help ensure early detection of mycoplasma contamination and same day actionable results, with a sensitive real-time PCR based mycoplasma detection assay.
Adventitious virus testing
Get accurate, rapid results from a system that is part of a total workflow solution and lessen your testing challenges in a GMP environment.
Protein quantitation
An immuno-PCR based quantitation platform for sensitive and robust protein quantitation with a wide dynamic range.
Microbial identification
Rapid, accurate identification of thousands of bacterial and fungal species typically in under 5 hours.
Purity test with SEC-HPLC
Separate biological molecules and polymers according to size using either SDS-PAGE / SEC-HPLC / capillary electrophoresis (reduced & nonreduced).
Sample preparation
A universal, magnetic bead–based sample preparation technology for efficient sample clean-up for reproducible contaminant and impurity testing.
Target discovery
Research into the biology and progression of a disease allows the identification and validation of druggable disease targets and their suitability for targeting with monoclonal antibody therapies.
Quick links: Genetic analysis | Protein analysis | Cell-based analysis | Commercialization solutions | Resources
Featured product
Silencer Select siRNA libraries
Highly potent and specific siRNAs covering human pre-defined gene families and pathways, including the druggable genome
TaqMan real-time PCR assays
96- or 384-well plate based pre-spotted with dried-down Applied Biosystems TaqMan Gene Expression Assays delivers results in only 30–45 min
ProcartaPlex immunoassays
Multiplex protein quantitation using the Luminex instrument platform, covering >300 cytokines, chemokines, growth factors, and other protein targets
TSX Series ultra-low freezers
Designed with features that support sustainability objectives without compromising performance
Immune repertoire with NGS
A rapid, long-read NGS tool for analyzing the immune repertoire to capture the diversity of T cell receptor (TCR) rearrangements.
Gene expression analysis using qPCR
Best-coverage assays to detect the highest number of transcript variants possible, with gold-standard specificity, sensitivity, and reproducibility.
Gene knockout using CRISPR-Cas9
Advanced gRNA designs for maximum efficiency without sacrificing specificity; arrayed libraries in flexible formats for a wide variety of assays.
Gene knockdown using siRNAs
Potent and specific siRNAs covering the druggable genome, with proprietary algorithm and chemical modifications.
Gene expression analysis using RNA sequencing
From targeted gene expression analysis to whole-transcriptome sequencing, combine simple sample preparation and intuitive data analysis.
Mass spectrometry
Understand the functions of individual proteins and their place in complex biological systems with state-of-the-art proteomics mass spectrometry.
Immunoassays
Investigate protein and RNA biomarkers in key disease research areas from single-analyte analysis using ELISA formats to multiplex bead-based assays.
Protein–protein interaction assays
Characterize protein interactions through methods such as immunoprecipitation, yeast two-hybrid screening, phage display, and more.
Protein structure analysis by cryo-electron microscopy
Generate complete structural information, uncover how antibodies function in the body, and show how they bind to antigens.
pH measurements
Make your pH measurements of your buffers and reagents fast and reliable with an extensive range of meters, electrodes and accessories designed to work seamlessly together.
Regulatory T cells (Treg) analysis
Understand the role of regulatory T cells with reagents for expansion, differentiation and functional studies, and cytokine profiling.
Cell function assays
A broad range of cell function and behavior assays and reagents that can be used on multiple instrument platforms.
Cell model creation
Closely mimic the in vivo state and generate more physiologically relevant data with complete cell culture systems for mAb discovery.
Immune response analysis by flow cytometry
Simultaneously analyze multiple proteins, gene expression, and cell functions such as oxidation, viability, cell cycle, apoptosis, and proliferation.
Biological safety cabinets
Maximise sample protection and user safety, with an emphasis on containment, comfort and convenience, all day, every day.
Antibody generation and engineering
Generate antibodies that bind to the target, then engineer to improve performance e.g., chimerization, humanization, manufacture of recombinant antibody fragments, bispecific antibodies, and antibody drug conjugates.
Featured product
GeneArt Gene Synthesis and Protein Services
Reliable and cost-effective method for obtaining customized DNA constructs with 100% sequence accuracy.
Custom peptide synthesis
Numerous options for synthesis platforms, purity levels, modifications, and formats to meet a variety of research needs.
Finnpipet F1 Pipettes
Improve accuracy and precision with pipetting systems that incorporate years of experience and innovation for consistent, reproducible results.
Gene synthesis for expression-ready genes
Preparation of optimized synthetic, expression-ready genes for stable and increased protein expression or DNA immunization.
Transient protein expression system
Rapidly produce high amounts of protein with integrated expression system solutions that give yield, speed, and cost benefits.
Custom peptide synthesis services
Peptides synthesized using the latest FMOC solid-phase technology, and purified using HPLC.
Carrier protein immunogens and adjuvants
Immunization adjuvants are used to increase or stimulate immune response when mixed and injected with prepared immunogens.
Serum-free hybridoma media
Chemically defined, protein-free formulation designed for maximum performance.
Transient protein expression platforms
High-density, serum-free suspension culture and specially designed transfection reagents for the highest yields possible in a transient system.
Phage display systems
High-quality magnetic beads with increased surface area for panning saturated phage solutions during phage display.
High-content screening
Platforms and software for cutting-edge images and high content imaging data in no time; exceptional resolution with subcellular, automated detection.
CO2 incubators
You can achieve your goals faster, more reliably and with less effort, with our technology advancements in contamination control and uniform growth conditions.
Gene synthesis for antibody DNA variant libraries
Create proteins with characteristics you need for affinity maturation; significantly reduce screening efforts compared to conventional mutagenesis.
Antibody characterization
The evaluation of biological and molecular/structural characteristics during development and production. Multi-attribute methods based on a combination of peptide mapping and mass spectroscopy are increasingly being used.
Featured product
CellInsight CX7 LZR Pro HCS Platform
A fast, laser-based, automated cellular imaging and analysis platform for quantitative microscopy and phenotypic screening.
EVOS M7000 Imaging System
High-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system.
Attune Flow Cytometers
Compact, benchtop cell analyser that can be configured with up to four spatially separated lasers to flexibly design, run, and analyse panels of up to 14 colors.
Barnstead Type 1 Water Purification
Deliver type 1 ultrapure water straight from your tap and benefit from easy-to-use configurations and lasting economy.
Immunoassays
Matched antibody pairs, uncoated and coated-plate ELISA kits, and multiplexing assays for reliability and specificity during ligand binding studies.
Cell function assays
Cell-based assays and reagents for key cellular processes, including apoptosis, cell proliferation, cell cycle and viability.
Biodistribution assays
A range of products for imaging biological processes in live animals to understand cellular activity, effects of drugs, and disease progression.
Immune response analysis by flow cytometry
Simultaneously analyze multiple proteins, gene expression, and cell functions such as oxidation, viability, cell cycle, apoptosis, and proliferation.
Automated reagent dispensing
A new workflow solution to increase throughput, reproducibility, and speed through automated reagent dispensing into a wide selection of plate and volume ranges.
Protein or peptide quantitation
A broad range of protein or peptide quantitation assays for your sample type and application.
Size heterogeneity analysis
SEC HPLC columns for monoclonal antibody, aggregate, and fractions separation.
Peptide mapping
A unique combination of innovative technologies in a start-to-finish workflow that is designed to be fast, reliable, reproducible, and easy to use.
Protein structure analysis with mass spectrometry
Obtain maximum insights on your most complex molecules and biological systems, from whole-proteome profiling and quantitation, structural characterization to multiplexed single-cell proteomics.
Charge variant analysis
A range of buffers, ion exchange or hydrophobic interaction column chemistries, and UHPLC instrumentation to meet the needs for robust analysis of charge variants in monoclonal antibodies.
Bioproduction and process development
Production of antibodies for clinical trials may include the use of alternative expression systems, continuous biomanufacturing systems, and non-chromatographic separation formats.
Featured product
Media manufacturing services
We are committed to meeting your toughest challenges with high-performing Gibco products and services customized to your research and production needs.
Single-use bioprocessing
Our proven, scalable technologies include bioprocessing equipment and automation, and flexible and rigid containment.
cGMP custom manufacturing
Take advantage of our fully validated cGMP media manufacturing services when you are ready for full-scale production.
Nalgene packaging bottles
Providing the most comprehensive range or customizable packaging solutions to protect your high-value liquids.
Stable cell line development
Integrated stable cell line development solutions to simplify your development workflow and accelerate your processes to commercial manufacture.
Cell culture media development and optimization
Optimize your media and processes for increased titers, quality, and manufacturability with our media development services.
Bioreactor systems
Scalability from research to cGMP manufacturing with a comprehensive bioreactor portfolio.
CO2 incubators
You can achieve your goals faster, more reliably and with less effort, with our technology advancements in contamination control and uniform growth conditions.
Affinity chromatography resins
Resins designed specifically for the purification of antibody fragments and novel antibody formats.
Bioprocess resins
For large scale manufacturing of biopharmaceuticals, high-performance and high-throughout resins.
Hydrophobic interaction chromatography
A suite of resins suitable for bind/elute and flow-through applications; purify a wide variety of biomolecules at low salt concentrations.
Residual host-cell DNA quantitation
Complete solution for extraction and quantitation of DNA from biopharmaceutical purification sample matrices.
Mycoplasma detection testing
Help ensure early detection of mycoplasma contamination and same day actionable results, with a sensitive real-time PCR based mycoplasma detection assay.
Adventitious virus testing
Get accurate, rapid results from a system that is part of a total workflow solution and lessen your testing challenges in a GMP environment.
Protein quantitation
An immuno-PCR based quantitation platform for sensitive and robust protein quantitation with a wide dynamic range.
Microbial identification
Rapid, accurate identification of thousands of bacterial and fungal species typically in under 5 hours.
Purity test with SEC-HPLC
Separate biological molecules and polymers according to size using either SDS-PAGE / SEC-HPLC / capillary electrophoresis (reduced & nonreduced).
Sample preparation
A universal, magnetic bead–based sample preparation technology for efficient sample clean-up for reproducible contaminant and impurity testing.
Opening a new lab space?
Simplify your new lab set-up. With Jump Start, we can help to design your lab with the products that will set you up for success, all with special discounts.
Essential lab equipment
Simplify processes and enable discovery with our innovative laboratory equipment—the essential infrastructure of science.
Scale-up solutions
Solutions for Biotech scale up to accommodate more samples, more data, and higher production.
Essential lab consumables
Simplify processes and enable discovery with our innovative laboratory consumables—the essential infrastructure of science.
Outsourcing services
No capacity, time, or resources to handle a project in-house? Outsource it to us and our staff of experts will handle the project for you.
Service and support packages
There’s no time for downtime in your lab, our services and support packages keep your lab up and running.
OEM & commercial supply
Customization, security of supply, quality, and expertise are values beyond the products and services when you partner with us.
The future of therapeutic monoclonal antibodies infographic
Antibody engineering technologies are constantly advancing, enabling the development of therapeutics with higher affinities and specificities. Download our infographic to learn more about navigating challenges at each stage of mAb development.
Key considerations for therapeutic monoclonal antibody development
Monoclonal antibody therapeutics have been rapidly increasing their market share over the last decade. Read our white paper to learn more about methods for screening target candidates, key assays for functional characterization, analytical methods for the molecular characterization, and much more.
Applications for therapeutic monoclonal antibodies
There is a growing need to improve and expand the range of tools for studying therapeutic mAbs as interest in this field of research intensifies. Read more about the latest technologies available to help you study antibody internalization and trafficking.
Innovative solutions for every stage of therapeutic antibody development
Thermo Fisher Scientific offers reliable solutions that help you design, characterize, and optimize candidates and maximize yield while also ensuring consistency, quality, and safety as you move toward clinical trials. Learn more about our end-to-end solutions in therapeutic antibody development.
For Research Use Only. Not for use in diagnostic procedures.
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