Search Thermo Fisher Scientific
- Order Status
- Quick Order
-
Don't have an account ? Create Account
Small Molecule Research and
Development Tools
Reliable solutions for accelerating small molecule drug development
By leveraging exciting new technologies at the leading edge of precision medicine, you’re helping to potentially stop some of the world’s deadliest diseases in their tracks. We have gathered feedback and know in order to speed these promising therapeutics to market, you’re committed to ensuring a high degree of accuracy and safety from discovery to commercialization of your small molecule drug.
We know you need a high-throughput screening method that’s biologically relevant, efficient, and sensitive, and an assay robust enough to determine accurate pharmacology. And by the time you’re ready to move to phase I clinical trials, we know you need to be confident that your drug is safe.
From CRISPR-Cas9 gene editing tools and transfection reagents to SelectScreen services and cell culture media, we provide expertise and an unparalleled array of scalable tools, services, and support designed to deliver high-quality results and accelerate your productivity and innovation. We are the partner you need to bring your small molecule drug to market with the goal of improving health care for millions of people.
View our comprehensive list of products, services, and technologies to support you at every step of small molecule drug development:
Target discovery
Target-based drug discovery identifies a new therapeutic target, then screens for a drug that binds to it. Target deconvolution begins with a drug that is efficacious in phenotypic studies and retrospectively identifies the target.
Quick links: Genetic analysis | Protein analysis | Cell-based analysis | Commercialization solutions
Featured products
LentiArray and LentiPool CRISPR Libraries
Arrayed or pooled lentiviral CRISPR libraries for functional genomics screening.
TaqMan real-time PCR assays
96- or 384-well plate based pre-spotted with dried-down Applied Biosystems TaqMan Gene Expression Assays delivers results in only 30–45 mins.
ProcartaPlex Immunoassays
Multiplex protein quantitation using the Luminex instrument platform, covering >300 cytokines, chemokines, growth factors, and other protein targets.
Cell proliferation assays
Broad range of assays for both flow cytometry and imaging (including microplate and HCS) applications
Sequencing solutions
Wide range of sequencing solutions from gold-standard Sanger sequencing technology, to flexible and scalable next-generation sequencing (NGS) products.
NGS library preparation kits for Illumina platforms
Generate libraries more quickly, with less bias, in order to match the speed and capacity of Illumina instruments.
Gene expression analysis using RNA sequencing
From targeted gene expression analysis to whole transcriptome sequencing, combine simple sample preparation and intuitive data analysis.
Gene expression analysis using qPCR
Best-coverage assays to detect the highest number of transcript variants possible, with gold-standard specificity, sensitivity, and reproducibility.
Gene knockdown using siRNAs
Potent and specific siRNAs covering the druggable genome, with a proprietary algorithm and chemical modifications.
Gene knockout using CRISPR-Cas9
Advanced gRNA designs for maximum efficiency without sacrificing specificity; arrayed libraries in flexible formats for a wide variety of assays.
Mass spectrometry
Understand the functions of individual proteins and their place in complex biological systems with state-of-the-art proteomics mass spectrometry.
Protein–protein interaction assays
Characterize protein interactions through methods such as immunoprecipitation, yeast two-hybrid screening, phage display, and more.
Protein structure analysis by cryo-electron microscopy
Generate complete structural information, uncover how targets interact with screening compounds.
Immunoassays
Investigate protein and RNA biomarkers in key disease research areas from single-analyte analysis using ELISA formats to multiplex bead-based assays.
Kinase assays
Create and validate an assay that meets your drug discovery or screening needs and fits your workflow.
Nuclear magnetic resonance (NMR)
Extract useful chemical information for verification studies, characterize new compounds and monitor reactions with compact, affordable spectrometers.
Cell function assays
A broad range of cell function and behaviour assays and reagents that can be used on multiple instrument platforms.
High-content screening analysis
Exceptional resolution with subcellular, automated detection and phenotyping with intact, fixed, or live cells.
Cell analysis by flow cytometry
Flow cytometry instruments, assays, reagents, and antibodies to simultaneously analyze multiple proteins, gene expression, and cell functions.
pH measurements
Make your pH measurements of your media, buffers, and reagents fast and reliable with meters, electrodes, and accessories designed to work seamlessly together.
Assay development and screening
Identify active compounds that interact with the selected target and/or modulate its activity via primary screening—i.e., hit identification. During secondary screening, evaluate and confirm initial hits with a different set of assays—i.e., hit validation.
Quick links: Cells and compound libraries | Functional analysis | Commercialization solutions
Featured products
Organoids, spheroids, and 3D cell culture
Better understand complex biology in a physiologically relevant context where 2D models have not proven as successful.
Attune Flow Cytometers
Compact, benchtop cell analyser that can be configured with up to four spatially separated lasers to flexibly design, run, and analyse panels of up to 14 colors.
CellInsight CX7 LZR Pro HCS Platform
A fast, laser-based, automated cellular imaging and analysis platform for quantitative microscopy and phenotypic screening.
Invitrogen EVOS M7000 Imaging System
High-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system.
Cell model creation
Closely mimic the in vivo state and generate more physiologically relevant data with complete cell culture systems for drug discovery.
Screening compound libraries
The Maybridge screening collection, a diverse set of >53,000 hit-like and lead-like molecules produced by synthetic techniques for screening campaigns.
Automated reagent dispensing
Increase throughput, reproducibility, and speed through automated reagent dispensing into a wide selection of plate and volume ranges.
Target-based assays
Investigate the major druggable target classes: kinases, GPCRs, nuclear receptors, and ion channels.
Pathway biology
Analyze complex signal transduction pathways in record time in live cells.
Epigenetic tools
Investigate epigenetic enzymes and substrate modifications using cellular and biochemical assays.
Reporter gene assays
Characterize gene regulatory sequences, transcription factor activity, cell signaling, and signaling pathways.
Cell function assays
Cell-based assays and reagents for key cellular processes, including apoptosis, cell proliferation, cell cycle and viability.
High-content screening
Platforms and software for cutting-edge images and high content imaging data in no time; exceptional resolution with subcellular, automated detection.
Biodistribution assays
A range of products for imaging biological processes in live animals to understand cellular activity, effects of drugs, and disease progression.
Protein structure analysis by cryo-electron microscopy
Generate complete structural information, uncover targets interact with screening compounds.
Screening and profiling
Services with strict quality controls and automated processes driven by integrated informatics systems to help ensure reliable data is delivered every time.
Robotics and lab automation
Comprehensive portfolio of laboratory automation solutions to improve processes and increase efficiency while generating accurate, reliable results.
CO2 incubators
Achieve your goals faster, more reliably and with less effort, with our technology advancements in contamination control and uniform growth conditions.
Biological safety cabinets
Maximize sample protection and user safety, with an emphasis on containment, comfort and convenience, all day, every day.
Lead optimization and toxicology
During lead optimization (LO), lead compounds are synthesized and modified to produce new analogs with improved potency and reduced off-target effects and tested to determine metabolic and safety profiles. Lead candidates are also tested for metabolic and safety profiles using ADME/Tox assays.
Featured products
Gibco Human Spheroid-Qualified Hepatocytes
Each vial contains a minimum of five million viable cells, sufficient for up to sixteen 96-well plates of hepatic spheroids.
LanthaScreen Binding Assays
Reagents to conduct TR-FRET–based compound affinity testing, suitable for high-throughput screening.
CYP450 screening assays
Human P450 isozyme for detailed drug metabolism studies, with multiple assay formats from 96-well to 1,536-well.
Toxicology products
Assays to identify indicators of both biochemical and cellular toxicity.
Hit-to-lead building blocks
Unparalleled, off-the-shelf collection of building blocks with medicinally important ring systems, many which are unique to the Maybridge collection.
Custom organic synthesis
ISO 9001:2000–certified facility, with experience in performing both small-scale and large-scale, milligram to kilogram, custom synthesis projects.
ADME/Tox products
High-grade hepatic systems (cells, media, supplements and matrices), backed by extensive expertise and decades of experience.
Target-based ADME/Tox assays
Determine the metabolic and safety profiles of lead candidates on a high-throughput scale.
Cold storage equipments
Ultra-low freezers, high-performance refrigerators and freezers are designed with features that support sustainability objectives without compromising performance.
Target discovery
Target-based drug discovery identifies a new therapeutic target, then screens for a drug that binds to it. Target deconvolution begins with a drug that is efficacious in phenotypic studies and retrospectively identifies the target.
Quick links: Genetic analysis | Protein analysis | Cell-based analysis | Commercialization solutions
Featured products
LentiArray and LentiPool CRISPR Libraries
Arrayed or pooled lentiviral CRISPR libraries for functional genomics screening.
TaqMan real-time PCR assays
96- or 384-well plate based pre-spotted with dried-down Applied Biosystems TaqMan Gene Expression Assays delivers results in only 30–45 mins.
ProcartaPlex Immunoassays
Multiplex protein quantitation using the Luminex instrument platform, covering >300 cytokines, chemokines, growth factors, and other protein targets.
Cell proliferation assays
Broad range of assays for both flow cytometry and imaging (including microplate and HCS) applications
Sequencing solutions
Wide range of sequencing solutions from gold-standard Sanger sequencing technology, to flexible and scalable next-generation sequencing (NGS) products.
NGS library preparation kits for Illumina platforms
Generate libraries more quickly, with less bias, in order to match the speed and capacity of Illumina instruments.
Gene expression analysis using RNA sequencing
From targeted gene expression analysis to whole transcriptome sequencing, combine simple sample preparation and intuitive data analysis.
Gene expression analysis using qPCR
Best-coverage assays to detect the highest number of transcript variants possible, with gold-standard specificity, sensitivity, and reproducibility.
Gene knockdown using siRNAs
Potent and specific siRNAs covering the druggable genome, with a proprietary algorithm and chemical modifications.
Gene knockout using CRISPR-Cas9
Advanced gRNA designs for maximum efficiency without sacrificing specificity; arrayed libraries in flexible formats for a wide variety of assays.
Mass spectrometry
Understand the functions of individual proteins and their place in complex biological systems with state-of-the-art proteomics mass spectrometry.
Protein–protein interaction assays
Characterize protein interactions through methods such as immunoprecipitation, yeast two-hybrid screening, phage display, and more.
Protein structure analysis by cryo-electron microscopy
Generate complete structural information, uncover how targets interact with screening compounds.
Immunoassays
Investigate protein and RNA biomarkers in key disease research areas from single-analyte analysis using ELISA formats to multiplex bead-based assays.
Kinase assays
Create and validate an assay that meets your drug discovery or screening needs and fits your workflow.
Nuclear magnetic resonance (NMR)
Extract useful chemical information for verification studies, characterize new compounds and monitor reactions with compact, affordable spectrometers.
Cell function assays
A broad range of cell function and behaviour assays and reagents that can be used on multiple instrument platforms.
High-content screening analysis
Exceptional resolution with subcellular, automated detection and phenotyping with intact, fixed, or live cells.
Cell analysis by flow cytometry
Flow cytometry instruments, assays, reagents, and antibodies to simultaneously analyze multiple proteins, gene expression, and cell functions.
pH measurements
Make your pH measurements of your media, buffers, and reagents fast and reliable with meters, electrodes, and accessories designed to work seamlessly together.
Assay development and screening
Identify active compounds that interact with the selected target and/or modulate its activity via primary screening—i.e., hit identification. During secondary screening, evaluate and confirm initial hits with a different set of assays—i.e., hit validation.
Quick links: Cells and compound libraries | Functional analysis | Commercialization solutions
Featured products
Organoids, spheroids, and 3D cell culture
Better understand complex biology in a physiologically relevant context where 2D models have not proven as successful.
Attune Flow Cytometers
Compact, benchtop cell analyser that can be configured with up to four spatially separated lasers to flexibly design, run, and analyse panels of up to 14 colors.
CellInsight CX7 LZR Pro HCS Platform
A fast, laser-based, automated cellular imaging and analysis platform for quantitative microscopy and phenotypic screening.
Invitrogen EVOS M7000 Imaging System
High-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system.
Cell model creation
Closely mimic the in vivo state and generate more physiologically relevant data with complete cell culture systems for drug discovery.
Screening compound libraries
The Maybridge screening collection, a diverse set of >53,000 hit-like and lead-like molecules produced by synthetic techniques for screening campaigns.
Automated reagent dispensing
Increase throughput, reproducibility, and speed through automated reagent dispensing into a wide selection of plate and volume ranges.
Target-based assays
Investigate the major druggable target classes: kinases, GPCRs, nuclear receptors, and ion channels.
Pathway biology
Analyze complex signal transduction pathways in record time in live cells.
Epigenetic tools
Investigate epigenetic enzymes and substrate modifications using cellular and biochemical assays.
Reporter gene assays
Characterize gene regulatory sequences, transcription factor activity, cell signaling, and signaling pathways.
Cell function assays
Cell-based assays and reagents for key cellular processes, including apoptosis, cell proliferation, cell cycle and viability.
High-content screening
Platforms and software for cutting-edge images and high content imaging data in no time; exceptional resolution with subcellular, automated detection.
Biodistribution assays
A range of products for imaging biological processes in live animals to understand cellular activity, effects of drugs, and disease progression.
Protein structure analysis by cryo-electron microscopy
Generate complete structural information, uncover targets interact with screening compounds.
Screening and profiling
Services with strict quality controls and automated processes driven by integrated informatics systems to help ensure reliable data is delivered every time.
Robotics and lab automation
Comprehensive portfolio of laboratory automation solutions to improve processes and increase efficiency while generating accurate, reliable results.
CO2 incubators
Achieve your goals faster, more reliably and with less effort, with our technology advancements in contamination control and uniform growth conditions.
Biological safety cabinets
Maximize sample protection and user safety, with an emphasis on containment, comfort and convenience, all day, every day.
Lead optimization and toxicology
During lead optimization (LO), lead compounds are synthesized and modified to produce new analogs with improved potency and reduced off-target effects and tested to determine metabolic and safety profiles. Lead candidates are also tested for metabolic and safety profiles using ADME/Tox assays.
Featured products
Gibco Human Spheroid-Qualified Hepatocytes
Each vial contains a minimum of five million viable cells, sufficient for up to sixteen 96-well plates of hepatic spheroids.
LanthaScreen Binding Assays
Reagents to conduct TR-FRET–based compound affinity testing, suitable for high-throughput screening.
CYP450 screening assays
Human P450 isozyme for detailed drug metabolism studies, with multiple assay formats from 96-well to 1,536-well.
Toxicology products
Assays to identify indicators of both biochemical and cellular toxicity.
Hit-to-lead building blocks
Unparalleled, off-the-shelf collection of building blocks with medicinally important ring systems, many which are unique to the Maybridge collection.
Custom organic synthesis
ISO 9001:2000–certified facility, with experience in performing both small-scale and large-scale, milligram to kilogram, custom synthesis projects.
ADME/Tox products
High-grade hepatic systems (cells, media, supplements and matrices), backed by extensive expertise and decades of experience.
Target-based ADME/Tox assays
Determine the metabolic and safety profiles of lead candidates on a high-throughput scale.
Cold storage equipments
Ultra-low freezers, high-performance refrigerators and freezers are designed with features that support sustainability objectives without compromising performance.
Opening a new lab space?
Simplify your new lab set-up: our Jump Start program can help you design your lab with the products that will set you up for success, all with special discounts.
Essential lab equipment
Simplify processes and enable discovery with our innovative laboratory equipment—the essential infrastructure of science.
Scale-up solutions
Solutions for Biotech scale up to accommodate more samples, more data, and higher production.
Essential lab consumables
Simplify processes and enable discovery with our innovative laboratory consumables—the essential infrastructure of science.
Outsourcing services
No capacity, time, or resources to handle a project in-house? Outsource it to us and our staff of experts will handle the project for you.
Service and support packages
There’s no time for downtime in your lab, our services and support packages keep your lab up and running.
OEM & commercial supply
Customization, security of supply, quality, and expertise are values beyond the products and services when you partner with us.
For Research Use Only. Not for use in diagnostic procedures.
Style Sheet for Global Design System
Hero banner dark gradient overlay