Pathogen-host research
Vaccine discovery
Vaccine production
Epidemiology
Resources
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The world has faced numerous outbreaks of infectious agents over the last 20 years, including Ebola, influenza, Zika, and novel coronaviruses (SARS, MERS, COVID-19). These pathogens have caused global economic disruption and strained public health resources.

Thermo Fisher Scientific has been at the forefront of these outbreaks, supporting scientists with gold-standard genetic analysis solutions, services, and support.

Download whitepaper ''Overview of the pathology, pathogenicity, and epidemiology of SARS-CoV-2''

The most common areas of research related to infectious diseases are:


Blog post: SARS-CoV-2
Omicron Variant Surveillance

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Infographic: Quickly identify early emergence of the SARS-CoV-2
Omicron variant

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Blog post: Sanger Sequencing & NGS
for SARS CoV-2 Omicron Variant Surveillance

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Featured webinars


Think Globally, Act Locally: The Importance of Coordinated Global and Community Genetic Surveillance Programs

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Strategies for Epidemiological Surveillance of SARS-CoV-2 Variants

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Solutions for SARS-CoV-2 Strain Lineage Surveillance

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Pathogen & host research

 

We offer comprehensive solutions that help with research into pathogenicity, host response, and underlying factors of host susceptibility and resistance.


Pathogen biology

Characterization of a pathogen’s genomic structures and methods of replication can help inform mutational rate analysis, pathogenesis, and virulence.

Our genetic analysis solutions for pathogen detection and genome analysis help with:

• Detection of pathogen presence
• Generation of a reference genome
• Identification of novel variants and key mutations



Solution selection guide


Host response

Understanding the host response to an infection can include large scale –omics and discovery approaches, targeted identification of important cells and proteins involved in the immune response.

Our genetic analysis solutions for host response help with:

• Identification of host genomic factors
• Study of RNA expression levels important in response to the infection
• Study of the innate and adaptive immune response by identifying types of cells and cytokines involved in the response against the pathogen

Solution selection guide

 

Vaccine/therapeutic discovery

 

It is important to understand disease mechanisms and the associated biomarkers to identify drug-gene targets and vaccine targets for the best immune response.

Our genetic analysis solutions for vaccine/therapeutic discovery help with:

  • Research of therapeutic agents that stimulate an immune response to create immunity to a specific pathogen
  • Identification of targets within the pathogen that will generate an immune response (T-cell/B-cell immunity)
  • Research of markers that will indicate positive response to the drug
  • Understanding of host response to ensure safety
  • Testing against immune response and toxicology panels
  • Understanding of drug response and dosage safety based on pharmacogenomic profiles

Solution selection guide

 

Vaccine/therapeutic production

 

Candidate & process development, manufacturing at scale​

Our genetic analysis solutions for vaccine/therapeutic production help to:

• Ensure that the cells being used for producing the vaccine are correct and free from contamination
• Ensure that the nucleic acids have the correct sequence
• Quantify the nucleic acids being used in the vaccine to confirm correct dosage
• Ensure that the final product is free of contaminating organisms

Solution selection guide

 

Epidemiology

 

It is key to monitor strain evolution, outbreak management, environmental monitoring, and population genomics.

Our genetic analysis solutions for epidemiology help with:

  • Identification and quantification of circulating strains
  • Characterization of differences in strain sequence over time or tracking and monitoring mutations
  • Understanding of host genomics factors for susceptibility, severity, and comorbidity
  • Characterization of wastewater composition for pathogen
  • Confirmation of virus specificity and origin

Solution selection guide

More information about epidemiological surveillance ›


Resources

The Science of SARS-CoV-2

Origins and pathogenicity of SARS-CoV-2

Learn about the origins of SARS-CoV-2 and how its unique genetic make-up affects those infected by the virus.

Vaccine and therapeutics

Learn about the vaccine and therapy development process and how mRNA delivery made it possible to have vaccines ready in months.

Epidemiological surveillance

Learn about the importance of virus tracking and how early warning has potentially stopped new variants.

Publications & blog posts

For Research Use Only. Not for use in diagnostic procedures.

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