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Single particle cryo-electron microscopy (cryo-EM) uses the particles extracted from thousands of images to reconstruct 3D structures of macromolecules. The yield of an acquisition session at the microscope depends on the time needed to set up the run and the speed of the acquisition itself. Thermo Scientific Smart EPU Software is an innovative, easy-to-use data acquisition solution for single particle analysis (SPA) that focuses on automation and user guidance to increase throughput and deliver reproducible results. Available on all our transmission electron microscopy (TEM) platforms, Smart EPU Software allows you to focus more on your research and make efficient use of your microscope.
Smart EPU Software is an ecosystem of multiple interactive software components that work together to drive automation of the data acquisition steps. The software enables advanced AI-guided decisions.
Thermo Scientific EPU 3 Software has been reimagined to allow both new and experienced microscopists to set up their experiments more quickly and easily. Features include:
EPU Multigrid Software allows users to take full advantage of their Autoloader by enabling them to setup and queue multiple data acquisition experiments to run unattended and overnight. Features include:
EPU Quality Monitor (EQM) Software analyzes and visualizes images on-the-fly, enabling users to judge image quality of running or completed acquisitions remotely. The combination of EPU Software, EQM Software, and smart plugins helps to generate high-quality results quickly and with confidence. Features of EQM Software include:
We have collaborated with Structura Biotechnology Inc. to develop an integrated version of CryoSPARC Live to significantly enhance efficiency of Thermo Scientific cryo-transmission electron microscopes (cryo-TEMs). This software shortens time to results by:
Providing real-time, multi-dimensional feedback on sample quality and TEM settings
Allowing imaging and processing parameter adjustments at any time to increase overall data quality
Integrating with Thermo Scientific Smart EPU Software to support a growing set of automations
Embedded CryoSPARC Live is installed on microscope hardware. Our digital service team provides support through installation and maintenance, and our application specialists provide integral workflow training.
Smart Plugins either use AI-based image analysis to automate the selection of grid areas suitable for further imaging or dynamically adjust EPU Software settings based on real-time image analysis software (EPU Quality Monitor Software or Embedded CryoSPARC Live™) output. The current plugins available in the Smart EPU Software include:
*CryoSPARC Live is a trademark of Structura Biotechnology Inc. and is used under license.
The Smart EPU ecosystem, through its open API, allows you to develop plugins that interact with Smart EPU Software.
EPU presets, microscope traffic lights, and smart automation benefit from artificial intelligence that captures the decisions of cryo-EM specialists in its algorithms.
Fast set-up time with EPU Multigrid Software for more efficient microscope usage, combined with throughput- and quality-enhancing automation and real-time feedback when intervention is needed during acquisition.
The use of automation algorithms and AI-guided decisions reduces operator variability, making outcomes more predictable.
We are committed to continuously improving the EPU experience through regular software updates. Smart EPU Software is supported by our service organization and application specialists.
For Research Use Only. Not for use in diagnostic procedures.