Advanced Metabolome Annotation with Orbitrap ID-X Tribrid Mass Spectrometer

Metabolite annotation is a current bottleneck in the broad implementation of metabolomics, hindering biological interpretation of results. In LC/MS based metabolomics, thousands of features from a single sample are routinely detected. However, not all features represent metabolites of biological origin and fragmentation spectra of background ions and degenerate signals detract from metabolite identification efforts. Thermo Fisher Scientific is addressing the identity crisis with novel workflow strategies for data acquisition and analysis. The AcquireX intelligent acquisition on the Orbitrap ID-X Tribrid MS automatically minimizes the fragmentation of background ions and degenerate signals, and efficiently generates more spectral information on relevant compounds. Advanced annotation tools like mzLogic in the Compound Discoverer software take advantage of information-rich data combined with the vast chemical knowledge of the mzCloud library increasing confidence in unknown annotation. Combining these sophisticated tools leads to comprehensive metabolome coverage and removes the identification barrier leading to confidence biological interpretation.

The speaker will discuss:

• Hardware and software advancements for improved metabolome coverage and increased confidence in unknown identification
• Intelligent data acquisition strategies for maximizing information-rich spectra of biologically relevant compounds
• Advanced annotation tools addressing the identification bottleneck in untargeted metabolomics

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