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HPLC System Cost Comparison Calculator
Thinking about investing in a new HPLC system?
This cost of ownership calculator helps you estimate your total cost for purchasing and running a Thermo Scientific HPLC system over a designated time period. Compare single channel LC against high-throughput workflows to find the best product for you.
Input your typical system use conditions and typical consumable costs associated with your current set-up to estimate many samples you can run in a year along with the expected cost per sample. See how applying tandem and dual LC workflows can increase your productivity and help reduce cost per sample for a quicker return on your investment.
Use at your own risk. Prepopulated data are estimates only. Thermo Fisher Scientific takes no responsibility for the accuracy of data, calculations or results.
Step 1: Choose a preset process OR start with minimum conditionals. After, enter your own adjustments.
Step 2: Review the results
Step 3: Review the charts
Number of Systems Required to Achieve
Target Number of
Samples Per Year
| Single | |
|---|---|
| Tandem | |
| Dual |
Number of Samples Per Day
Step 4: Compare
Most accurate results require content in these fields
| Single Channel LC | Tandem LC or LC-MS | Dual LC | |
|---|---|---|---|
 Click to enlarge |  Click to enlarge |  Click to enlarge | |
| System Cost ($) | |||
| Yearly Maintenance Costs ($) | |||
| Yearly Labor and Overhead Costs ($) | |||
| Additional Cost Per Sample ($) | |||
| System Type | |||
| Cost Per
Sample
($) Based on the maximum number of samples | |||
| Number of Samples Per Day Per System | |||
| Number of Samples Per Year Per System | |||
| Yearly System, Maintenance, Overhead Costs ($) | |||
| Yearly Column and Consumable Costs ($) | |||
| Yearly Solvent Costs ($) |
| System A | System B | |
|---|---|---|
| System Cost ($) | ||
| Yearly Maintenance Costs ($) | ||
| Yearly Labor and Overhead Costs ($) | ||
| Additional Cost Per Sample ($) | ||
| System Type | ||
| Cost Per
Sample
($) Based on the maximum number of samples | ||
| Number of Samples Per Day Per System | ||
| Number of Samples Per Year Per System | ||
| Yearly System, Maintenance, Overhead Costs ($) | ||
| Yearly Column and Consumable Costs ($) | ||
| Yearly Solvent Costs ($) |
Step 5: Choose product
| Vanquish Core HPLC Systems | Vanquish Flex UHPLC Systems | Vanquish Horizon UHPLC Systems | Vanquish Neo UHPLC System |
|---|---|---|---|
| General application | |||
| Dependable routine HPLC analysis | Flexible HPLC and UHPLC method development | Top performance and resolution for demanding UHPLC separations | Maximum low-flow performance for high-sensitivity LC-MS workflows |
| Pump options | |||
| Binary, Quaternary, Dual and Isocratic | Binary, Quaternary and Dual | Binary | Binary |
| System pressure | |||
| Up to 700 bar | Up to 1000 bar | Up to 1500 bar | Up to 1500 bar |
| Flow range | |||
| 0.001 – 10 mL/min | 0.001 – 8 mL/min | 0.001 – 5 mL/min | 1 nL/min – 100 µL/min |
| Biocompatible | |||
| No | Yes | Yes | Yes |
| Common detector setup | |||
| Up to 2 detectors and/or 1 mass spectrometer | Up to 2 detectors and/or 1 mass spectrometer | Up to 2 detectors and/or 1 mass spectrometer | 1 VWD and/or 1 mass spectrometer |
| Vanquish Duo UHPLC Systems | Transcend VLX-2 UHPLC Systems | Vanquish Tandem LC Systems |
|---|---|---|
| Benefit | ||
| Doubled productivity with 2 independent UHPLC channels built into one stack | Integrated multi-channel LC for ultra-high-throughput LC-MS | Maximized detector utilization by using offline column reconditioning |
| Supported systems | ||
| Vanquish Flex Vanquish Horizon | Vanquish Flex Vanquish Horizon | Vanquish Core Vanquish Flex Vanquish Horizon |
| Common detector setup | ||
| 1-2 detectors per channel (2-4 detectors per system) | 1 mass spectrometer | Up to 2 detectors and/or 1 mass spectrometer |
| Software control | ||
| Thermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Waters™ Empower™ 3 CDS software | Thermo Scientific Aria MX software | Thermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Thermo Scientific XCalibur software |
| Vanquish Flex Duo Ternary UHPLC System with 2 Detectors | |
|---|---|
| Pump type: | DPG (Vanquish Dual Pump F) |
| Maximum pressure: | 1000 bar, 15,000 psi |
| Autosampler: | Dual (Vanquish Dual Split Sampler FT) |
| Column switching: | N/A |
| Detectors required: | 2 x Vanquish Detectors and/or Mass Spectrometer |
| Vanquish Flex Duo Binary UHPLC System with 2 Detectors | |
|---|---|
| Pump type: | 2 x HPG (Vanquish Binary Pump F) |
| Maximum pressure: | 1000 bar, 15,000 psi |
| Autosampler: | Dual (Vanquish Dual Split Sampler FT) |
| Column switching: | N/A |
| Detectors required: | 2 x Vanquish Detectors and/or Mass Spectrometer |
| Vanquish Horizon Duo Binary UHPLC System with 2 Detectors | |
|---|---|
| Pump type: | 2 x HPG (Vanquish Binary Pump H) |
| Maximum pressure: | 1500 bar, 22,000 psi |
| Autosampler: | Dual (Vanquish Dual Split Sampler HT) |
| Column switching: | N/A |
| Detectors required: | 2 x Vanquish Detectors and/or Mass Spectrometer |