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Immunology at Work is here for you, whether you want to review the basics, gain more in-depth knowledge, or discover the latest research tools. This resource hub contains rich and reliable technical content designed for new and experienced life scientists alike exploring the field of immunology.
We interviewed Hervé Luche, PhD.
Learn more about image-enhanced flow cytometry they discussed.
We interviewed Cyrille Mionnet, PhD.
Learn more about NovaFluor dyes they discussed.
Biomarker research in immunology offers crucial insights for disease diagnosis, prognosis, treatment response, mechanistic understanding, drug development, and predictive/preventive medicine.
Discover the different immune cells and their role in immunology. For each cell category, you can find information on its development, differentiation, effector function, and role in disease, as well as common methods used for its study and cellular markers that are relevant for phenotyping. Click on the cell type below to learn more.
NK cells kill pathogen infected cells and cancer cells. They also release cytokines, which alert and attract other immune cells.
Lineage of CD4+ T helper cells that promote immune response required for host defense against intracellular viral and bacterial pathogens.
Subset of CD4+ T helper cells that trigger germinal center B cells into antibody-secreting plasma and memory B cells.
Circulating immune cells that engulfs (phagocytosis) and activates other immune cells.
Lineage of CD4+ T helper cells that promote humoral immunity critical for host defense against extracellular pathogens.
T cells, also know as CD8+ cells, that kill virus infected cells and cancer cells by releasing toxic chemicals.
Professional phagocytic tissue resident cells that destroy foreign antigens/cells by phagocytosis. They release cytokines that attract and activates other immune cells.
T cells critical to the maintenance of self-tolerance and immune cell homeostasis.
Phagocytic antigen presenting cells with an important role in alerting T cells to new pathogens. They act as key mediators between the innate and adaptive immune systems.
CD4+ T helper cells that play a critical role in the activation of other immune cells such as B cells and cytotoxic T cells, as well as in the regulation of immune responses.
B cells play a critical role in the adaptive immune response, producing high-affinity antibodies, acting as antigen-presenting cells, and secreting cytokines.
Granulocytes are a heterogenous category of leukocytes, comprising neutrophils, eosinophils, basophils, and mast cells.
Invariant natural killer T (iNKT) cells display properties of both T cells and natural killer (NK) cells and help to bridge the innate and adaptive immune responses.
Inflammation is an organism’s protective response to pathogens, infection, or tissue damage and involves the coordinated communication of a variety of immune cells and blood vessels. Understand the general phenomenon of inflammation and triggers to the process.
Learn about cell types, cytokines, and markers involved with uncontrolled inflammation.
Find information on pattern-recognition receptors (PRRs) including pathogen-associated molecular patterns (PAMPs) and damage-associated molecules patterns (DAMPs).
Find information on viral attachment and entry, replication, maturation, and release.
Interferon (IFN) proteins are a family of cytokines secreted by host cells to modulate the immune response. Find information on interferon types and induction.
Cytokines are small secreted proteins that are key modulators of inflammation. Discover how pro-inflammatory cytokines play a role in the immune response.
Apply the background information provided throughout this resource center with practical and relevant application protocols. Browse by application or technique:
Find detailed protocols on the isolation of the different immune cells starting from whole blood or lymphoid tissue and various methods to stimulate them.
Protocols covering isolation of RNA from immune cells to sample preparation for immunoassays.
Detailed protocols on staining, compensation, and validated antibody panels.
Find general protocols for ELISA, western blot analysis, and immunohistochemistry.
A collection of general western blotting protocols for chemiluminescent and fluorescent detection.
Protocols in flow cytometry ranging from sample preparation to numerous cell stimulation conditions, staining, immunophenotyping and data analysis strategies.
Learn about our comprehensive suite of flow cytometry solutions to deliver you high-performance results and save you time.
A handy reference poster featuring the broad range of Invitrogen labeling reagents available for flow cytometry.
Let us help you navigate the different tools available for protein and RNA quantitation with valuable technical and product information.
Get the latest in flow cytometry and cell sorting innovation in these collections of articles.
An extensive selection of Invitrogen eBioscience antibody conjugates of human CD markers.
View the many options for multicolor flow cytometry research in one place.
Discover immune cell markers for humans and mice. CD and non-CD markers, alternate antigen names, distribution, and function.
Find on-demand tutorials and register for upcoming webinars to get firsthand knowledge of the latest technologies to accelerate your immunology research.
Cell-based assays to functionally characterize immunotherapy and the immune response to viral infection.
Digital tools to make your experimental planning easier.
Design your flow cytometry panels effortlessly with our FREE Panel Design Service by our scientists, or use our Panel Builder Tool for a DIY approach.
Assess the spectral compatibility of dyes and probes for experiments that utilize fluorescence detection techniques.
Design your own multiplex immunoassay for protein detection using a Luminex instrument.
Learn about the scientists who helped put this resource center together.
We asked scientists in immunology research about the challenges they face, how they overcome them and what keeps them motivated. What we learned was so inspiring that we created this space to share their stories with you.
“I feel blessed that I have a family that I love, that I can do what I love to do. Knowing that some people are restrained, they have disease that doesn't allow them to have a similar life as me, that drives me.”
“I was a cancer patient and a cancer survivor 25 years ago. I had these questions about how my disease would go. And that's exactly the work that we do here at Talon.”
“It's not just about publishing in high impact journals, but also ensuring that the outcome has very practical use, to change lives.”
An idea is like a spark in the dark. It makes everything brighter. This blog series uncovers common challenges in immunology research experiments and spark different ways of thinking to discover solutions.
How can you bring flow cytometry panel design up to speed?
How much data can you get from a single sample in immunoassays?
Why are protocols hard to find?
How cell sorting is becoming an even more powerful tool?
How cell images enable more accuracy in flow cytometry data
How to compare your flow cytometry data across experiments?
What are ways of expanding flow cytometry panels?
What are the benefits of performing proteomics and genomics assays on the same instrument?
For Research Use Only. Not for use in diagnostic procedures.