Product References
Hydrogen sulfide inhibits Ca2+-induced mitochondrial permeability transition pore opening in type-1 diabetes.
American journal of physiology. Endocrinology and metabolism
Papu John AS,Kundu S,Pushpakumar S,Amin M,Tyagi SC,Sen U
PA3-022 was used in Western Blot to show that NMDA-R1-mediated Ca2+ influx in diabetes induces MPTP opening via CypD activation leading to increased oxidative stress and renal injury, and H2S protects diabetic kidney from injury by blocking mitochondrial Ca2+ permeability through NMDA-R1 pathway.
Thu Aug 01 00:00:00 EDT 2019
Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus.
Redox biology
Jara C,Aránguiz A,Cerpa W,Tapia-Rojas C,Quintanilla RA
PA3-022 was used in Western Blotting to investigate the implications of tau ablation on the mitochondrial function and cognitive abilities of a litter of 3 months old mice.
Sat Sep 01 00:00:00 EDT 2018
A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death.
BMC neuroscience
Kim H,Lee JY,Park KJ,Kim WH,Roh GS
PA3-022 was used in western blot to study inhibition of mitochondrial fragmentation and attenuation of kainic acid-induced hippocampal cell death by a mitochondrial division inhibitor, Mdivi-1
Fri Jun 10 00:00:00 EDT 2016
FKBP51 controls cellular adipogenesis through p38 kinase-mediated phosphorylation of GRα and PPARγ.
Molecular endocrinology (Baltimore, Md.)
Stechschulte LA,Hinds TD,Khuder SS,Shou W,Najjar SM,Sanchez ER
PA3-022 was used in western blot to explore the effects of FK506-binding protein 51 (FKBP51) deletion on adipogenesis
Fri Aug 01 00:00:00 EDT 2014
Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40.
Analytical biochemistry
Park MS,Chu F,Xie J,Wang Y,Bhattacharya P,Chan WK
PA3-022 was used in western blot to identify cyclophilin-40-interacting proteins and the cellular functions of cyclophilin-40
Tue Mar 15 00:00:00 EDT 2011
Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40.
Analytical biochemistry
Park MS,Chu F,Xie J,Wang Y,Bhattacharya P,Chan WK
PA3-022 was used in western blot to identify cyclophilin-40-interacting proteins and the cellular functions of cyclophilin-40
Tue Mar 15 00:00:00 EDT 2011
Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion.
Virology journal
Anderson LJ,Lin K,Compton T,Wiedmann B
Published figure using Cyclophilin 40 polyclonal antibody (Product # PA3-022) in Western Blot
Tue Jun 28 00:00:00 EDT 2011
Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion.
Virology journal
Anderson LJ,Lin K,Compton T,Wiedmann B
Published figure using Cyclophilin 40 polyclonal antibody (Product # PA3-022) in Western Blot
Tue Jun 28 00:00:00 EDT 2011
FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A.
Oncogene
Periyasamy S,Hinds T,Shemshedini L,Shou W,Sanchez ER
PA3-022 was used in western blot to study the expression of FKBP51 and Cyp40 in prostate cancer tissues and their role in promoting androgen-dependent cell growth
Thu Mar 18 00:00:00 EDT 2010
The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events.
Molecular and cellular biology
Galigniana MD,Erlejman AG,Monte M,Gomez-Sanchez C,Piwien-Pilipuk G
PA3-022 was used in western blot to investigate the role of the heat shock protein 90-FKBP52 complex in the nucleus
Mon Mar 01 00:00:00 EST 2010
Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice.
Endocrinology
Warrier M,Hinds TD,Ledford KJ,Cash HA,Patel PR,Bowman TA,Stechschulte LA,Yong W,Shou W,Najjar SM,Sanchez ER
PA3-022 was used in western blot to study the role of FK506-binding protein 52 in hepatic integrity and glucocorticoid responsiveness in mice
Thu Jul 01 00:00:00 EDT 2010
Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors.
PloS one
Schülke JP,Wochnik GM,Lang-Rollin I,Gassen NC,Knapp RT,Berning B,Yassouridis A,Rein T
PA3-022 was used in western blot and western blot to investigate the effect of the tetratricopeptide repeat proteins on steroid receptors
Thu Jul 22 00:00:00 EDT 2010
Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity.
The Journal of steroid biochemistry and molecular biology
Wolf IM,Periyasamy S,Hinds T,Yong W,Shou W,Sanchez ER
PA3-022 was used in western blot to investigate the role of FKBP52 in regulation of glucocorticoid receptor (GR) activity in vivo
Thu Jan 01 00:00:00 EST 2009
Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity.
The Journal of steroid biochemistry and molecular biology
Wolf IM,Periyasamy S,Hinds T,Yong W,Shou W,Sanchez ER
PA3-022 was used in western blot to investigate the role of FKBP52 in regulation of glucocorticoid receptor (GR) activity in vivo
Thu Jan 01 00:00:00 EST 2009
Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling.
FEBS letters
Luu TC,Bhattacharya P,Chan WK
PA3-022 was used in immunocytochemistry and western blot to study the important roles of CyP40 in the AhR signaling
Mon Sep 22 00:00:00 EDT 2008
Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling.
FEBS letters
Luu TC,Bhattacharya P,Chan WK
PA3-022 was used in immunocytochemistry and western blot to study the important roles of CyP40 in the AhR signaling
Mon Sep 22 00:00:00 EDT 2008
Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling.
FEBS letters
Luu TC,Bhattacharya P,Chan WK
PA3-022 was used in immunocytochemistry and western blot to study the important roles of CyP40 in the AhR signaling
Mon Sep 22 00:00:00 EDT 2008
Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins.
Biochemistry
Banerjee A,Periyasamy S,Wolf IM,Hinds TD,Yong W,Shou W,Sanchez ER
Published figure using Cyclophilin 40 polyclonal antibody (Product # PA3-022) in Immunofluorescence
Tue Sep 30 00:00:00 EDT 2008
Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins.
Biochemistry
Banerjee A,Periyasamy S,Wolf IM,Hinds TD,Yong W,Shou W,Sanchez ER
Published figure using Cyclophilin 40 polyclonal antibody (Product # PA3-022) in Immunofluorescence
Tue Sep 30 00:00:00 EDT 2008
Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins.
Biochemistry
Banerjee A,Periyasamy S,Wolf IM,Hinds TD,Yong W,Shou W,Sanchez ER
Published figure using Cyclophilin 40 polyclonal antibody (Product # PA3-022) in Immunofluorescence
Tue Sep 30 00:00:00 EDT 2008
Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins.
Biochemistry
Banerjee A,Periyasamy S,Wolf IM,Hinds TD,Yong W,Shou W,Sanchez ER
Published figure using Cyclophilin 40 polyclonal antibody (Product # PA3-022) in Immunofluorescence
Tue Sep 30 00:00:00 EDT 2008
The immunophilin ligands cyclosporin A and FK506 suppress prostate cancer cell growth by androgen receptor-dependent and -independent mechanisms.
Endocrinology
Periyasamy S,Warrier M,Tillekeratne MP,Shou W,Sanchez ER
PA3-022 was used in western blot to study the effect of immunophilin ligands cyclosporin A and FK506 on prostate cancer cell growth and its mechanism
Mon Oct 01 00:00:00 EDT 2007
Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology.
The Journal of biological chemistry
Yong W,Yang Z,Periyasamy S,Chen H,Yucel S,Li W,Lin LY,Wolf IM,Cohn MJ,Baskin LS,Sa Nchez ER,Shou W
PA3-022 was used in western blot to study the roles of FKBP52 and FKBP51 in androgen receptor functions.
Fri Feb 16 00:00:00 EST 2007
Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506.
Biochemistry
Davies TH,Ning YM,Sánchez ER
PA3-022 was used in western blot to investigate the regulatory effects of FK506 and TPR proteins on glucocorticoid receptor hormone-binding function
Tue Feb 15 00:00:00 EST 2005
Physiological role for the cochaperone FKBP52 in androgen receptor signaling.
Molecular endocrinology (Baltimore, Md.)
Cheung-Flynn J,Prapapanich V,Cox MB,Riggs DL,Suarez-Quian C,Smith DF
PA3-022 was used in western blot to characterize FKBP52 and study its roles in some male reproductive tissues.
Wed Jun 01 00:00:00 EDT 2005
Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria.
Circulation research
Baines CP,Song CX,Zheng YT,Wang GW,Zhang J,Wang OL,Guo Y,Bolli R,Cardwell EM,Ping P
PA3-022 was used in western blot to study the role of PKC epsilon in cardiac mitochondria
Fri May 02 00:00:00 EDT 2003
p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules.
Biochemistry
Hartson SD,Irwin AD,Shao J,Scroggins BT,Volk L,Huang W,Matts RL
PA3-022 was used in western blot to investigate the role of p50(cdc37) in heat shock protein 90 molecular chaperone function
Tue Jun 27 00:00:00 EDT 2000
Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90, and cytoplasmic dynein.
The Journal of biological chemistry
Silverstein AM,Galigniana MD,Kanelakis KC,Radanyi C,Renoir JM,Pratt WB
PA3-022 was used in western blot to study the binding site for the association between FKBP52/dimer and hsp90
Fri Dec 24 00:00:00 EST 1999
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1.
Cell
Zou J,Guo Y,Guettouche T,Smith DF,Voellmy R
PA3-022 was used in immunoprecipitation to show that CyP40 can not activate heat shock transcription factor 1
Fri Aug 21 00:00:00 EDT 1998
The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.
Molecular and cellular biology
Whitesell L,Sutphin PD,Pulcini EJ,Martinez JD,Cook PH
PA3-022 was used in immunohistochemistry to investigate the mechanisms for the aberrant association of chaperones and mutant p53 and the intracellular accumulation of mutant p53.
Sun Mar 01 00:00:00 EST 1998
Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants.
Cell stress & chaperones
Chen S,Sullivan WP,Toft DO,Smith DF
PA3-022 was used in immunoprecipitation to investigate the interaction of various Hsp90 mutants with PR complexes and Hsp90 accessories in vitro
Mon Jun 01 00:00:00 EDT 1998
p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site.
The Journal of biological chemistry
Silverstein AM,Grammatikakis N,Cochran BH,Chinkers M,Pratt WB
PA3-022 was used in western blot to investigate the mechanism for the interactions among cdc37, Raf, and hsp90
Fri Aug 07 00:00:00 EDT 1998
Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor.
Molecular and cellular biology
Nair SC,Rimerman RA,Toran EJ,Chen S,Prapapanich V,Butts RN,Smith DF
PA3-022 was used in western blot to study the interactions between Hsp90-associated immunophilins and target proteins
Sat Feb 01 00:00:00 EST 1997
A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor.
Cell stress & chaperones
Nair SC,Toran EJ,Rimerman RA,Hjermstad S,Smithgall TE,Smith DF
PA3-022 was used in western blot to show the involvement of Cyp40 in the formation of unactivated progesterone receptor complex
Sun Dec 01 00:00:00 EST 1996
The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant.
The Journal of biological chemistry
Chen MS,Silverstein AM,Pratt WB,Chinkers M
PA3-022 was used in western blot to investigate the role of tetratricopeptide repeat (TPR) domain of protein phosphatase 5 (PP5) in GR signaling
Fri Dec 13 00:00:00 EST 1996
Reconstitution of the steroid receptor.hsp90 heterocomplex assembly system of rabbit reticulocyte lysate.
The Journal of biological chemistry
Dittmar KD,Hutchison KA,Owens-Grillo JK,Pratt WB
PA3-022 was used in western blot to reconstitute a minimal GR-hsp90 heterocomplex assembly system
Fri May 31 00:00:00 EDT 1996
Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent.
Molecular and cellular biology
Smith DF,Whitesell L,Nair SC,Chen S,Prapapanich V,Rimerman RA
PA3-022 was used in western blot to investigate the assembly pathway of progesterone receptor complexes
Fri Dec 01 00:00:00 EST 1995
Cyclophilin-40: evidence for a dimeric complex with hsp90.
The Biochemical journal
Hoffmann K,Handschumacher RE
PA3-022 was used in western blot to identify the cellular components interacting with CyP-40
Sat Apr 01 00:00:00 EST 1995
Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A.
Molecular endocrinology (Baltimore, Md.)
Milad M,Sullivan W,Diehl E,Altmann M,Nordeen S,Edwards DP,Toft DO
PA3-022 was used in western blot to investigate the interaction between progesterone receptor complexes and immunophilins
Sat Jul 01 00:00:00 EDT 1995
The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor.
The Journal of biological chemistry
Owens-Grillo JK,Hoffmann K,Hutchison KA,Yem AW,Deibel MR,Handschumacher RE,Pratt WB
PA3-022 was used in western blot to investigate the role of immunophilins in steroid receptor action
Fri Sep 01 00:00:00 EDT 1995
