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Invitrogen
H2A.Zac pan-acetyl (K4,K7,K11) Polyclonal Antibody
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 9
H2A.Zac pan-acetyl (K4,K7,K11) Antibody (PA5-40095) in ChIP-seq
ChIP was performed with 1 µg of Acetyl-Histone H2A.Z (Lys4 + Lys7 +Lys11) polyclonal antibody (Product # PA5-40095) on sheared chromatin from 1 million HeLaS3 cells. IgG (2 µg/IP) was used as a negative IP control. The IP'd DNA was analyzed by QPCR. The IP'd DNA was subsequently analyzed with a Genome Analyzer. The 36 bp tags were aligned to the human genome using the ELAND algorithm. Figure 2 shows the pea... View More
Product Details
PA5-40095
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH-conjugated synthetic peptide corresponding to human histone H2A.Z acetylated at lysines 4, 7, and 11.
Conjugate
Form
Liquid
Concentration
1.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.05% sodium azide, 0.05% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609565
Target Information
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 11ac; Acetyl-Histone H2A.Z K4 K7 K11; Acetyl-Histone H2A.Z Lys4 Lys7 Lys11; H2A histone family, member V; H2A histone family, member Z; H2A.F/Z; H2A.Z variant histone 2; H2A.ZK4,7,11ac; H2A.ZK5; H2A.ZK5ac; H2A.ZLys4,7,11ac; H2A/z; H2AFZac; H2AZ histone; H2AZK11ac; H2AZK4,7,11ac; H2AZK7ac; H2AZLys4,7,11ac; histone H2A.F/Z; Histone H2A.V; Histone H2A.Z; purine-rich binding element protein B
Gene Aliases: H2A.z; H2A.Z-1; H2A.Z-2; H2A/z; H2AFV; H2AFZ; H2AV; H2AZ; H2AZ1; H2AZ2
UniProt ID: (Human) Q71UI9, (Human) P0C0S5
Entrez Gene ID: (Human) 94239, (Human) 3015
molecular_function
DNA binding
protein heterodimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
protein binding
chromatin DNA binding
nucleosomal DNA binding
histone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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