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Product Details
RP-87946
Applications
Tested Dilution
Publications
Product Specifications
Species
Cynomolgus monkey
Expression System
HEK293 cells
Amino acid sequence
Cynomolgus IL-13, amino acids Ser21-Asn132 (Accession # ABG75889.1) with an N-terminal His-tag
Tag
His-tag
Molecular weight
25-35 kDa
Class
Recombinant
Type
Protein
Purity
>95% as determined by SDS-PAGE.
Endotoxin concentration
<1.0 EU/µg
Activity
1. Measured by its binding ability in a functional ELISA. Immobilized cynomolgus IL-13 at 4 µg/ml (100 µL/well) can bind human IL13RA1 with a linear range of 0.156-2.5 µg/ml. 2. Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The ED50 for this effect is typically 100-400 ng/mL.
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS, pH 7.4, with 15% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
Reconstituted with sterile deionized water to 0.25 mg/mL.
Concentration is measured by UV.
Target Information
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALRH; ALRH antibody; BHR1; il 13; ILN; Interleukin; Interleukin13; MGC116786; MGC116788; MGC116789; NC30 antibody; P600 antibody
Entrez Gene ID: (Cynomolgus monkey) 102125887
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