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Product Details
RP-75635
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
Amino acids Gly311- Ser426 containing an N-terminal His-tag
Tag
His-tag
Molecular weight
17.47 kDa
Class
Recombinant
Type
Protein
Purity
>95%, by SDS-PAGE under reducing conditions
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
purified
Storage buffer
Laemmli, pH 6.8
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
RP-75635 contains a purified 116 amino acid fragment (aa311-426) corresponding to the mature Inhibin beta A chain protein with an N-terminal hexahistidine tag.
RP-75635 may be used as a positive control in Western blot assays.
Target Information
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activin beta-A chain; EDF; erythroid differentiation factor; Erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1
Gene Aliases: EDF; FRP; INHBA
UniProt ID: (Human) P08476
Entrez Gene ID: (Human) 3624
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