Product References
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
120-05ET was used in Cell Culture to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 EDT 2023
A simplified and defined serum-free medium for cultivating fat across species.
iScience
Mitić R,Cantoni F,Börlin CS,Post MJ,Jackisch L
120-05ET was used in Cell Culture to propose a simplified one-step adipogenic protocol which, given the replacement of rosiglitazone by a food-compatible PPARγ agonist, is suitable for making cultivated fat.
Fri Jan 20 00:00:00 EST 2023
Protocol to generate cardiac pericytes from human induced pluripotent stem cells.
STAR protocols
Shen M,Zhao SR,Khokhar Y,Li L,Zhou Y,Liu C,Wu JC
120-05ET was used in Cell Culture to present a protocol to generate them from human induced pluripotent stem cells (hiPSCs).
Thu Apr 27 00:00:00 EDT 2023
LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells.
Viruses
Zhang L,Bisht P,Flamier A,Barrasa MI,Friesen M,Richards A,Hughes SH,Jaenisch R
120-05ET was used in Cell Culture to conclude that retrotransposition in virus-infected cells, in contrast to transfected cells, may be facilitated because virus infection, in contrast to viral RNA transfection, results in significantly higher viral RNA levels and stimulates LINE1 expression by causing cellular stress.
Sat Feb 25 00:00:00 EST 2023
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.
Communications biology
Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H
120-05ET was used in In vitro experiments to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.
Sat Apr 29 00:00:00 EDT 2023
Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells.
Cell reports methods
Iwatsuki K,Oikawa M,Kobayashi H,Penfold CA,Sanbo M,Yamamoto T,Hochi S,Kurimoto K,Hirabayashi M,Kobayashi T
120-05ET was used in In vitro experiments to demonstrate that rat EpiSCs retain competency to produce authentic primordial germ cell-like cells that undergo functional gametogenesis leading to the birth of viable offspring.
Mon Aug 28 00:00:00 EDT 2023
Biophysical, Molecular and Proteomic Profiling of Human Retinal Organoid-Derived Exosomes.
Pharmaceutical research
Arthur P,Kandoi S,Sun L,Kalvala A,Kutlehria S,Bhattacharya S,Kulkarni T,Nimma R,Li Y,Lamba DA,Singh M
120-05ET was used in Cell Culture to provide supplementary knowledge on the properties of retinal organoid EVs and suggests their potential use in the diagnostic and therapeutic treatments for ocular diseases.
Sat Apr 01 00:00:00 EDT 2023
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment.
Stem cell reports
Rudraraju R,Gartner MJ,Neil JA,Stout ES,Chen J,Needham EJ,See M,Mackenzie-Kludas C,Yang Lee LY,Wang M,Pointer H,Karavendzas K,Abu-Bonsrah D,Drew D,Yang Sun YB,Tan JP,Sun G,Salavaty A,Charitakis N,Nim HT,Currie PD,Tham WH,Porrello E,Polo JM,Humphrey SJ,Ramialison M,Elliott DA,Subbarao K
120-05ET was used in In vitro experiments to provide new insights into rational drug combinations for effective treatment of a virus that affects multiple organ systems.
Tue Jun 13 00:00:00 EDT 2023
Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.
Methods in molecular biology (Clifton, N.J.)
Chen SW,Wong YH
120-05ET was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.
Mon Jun 12 00:00:00 EDT 2023
Derivation of Human Extraembryonic Mesoderm-like Cells from Primitive Endoderm.
International journal of molecular sciences
Farkas K,Ferretti E
120-05ET was used in In vitro experiments to find that the ExM-like cells clustered with the LUM/ANXA1-rich cell populations of the gastrulating embryo, indicating similarity between in vitro and ex utero cell populations.
Wed Jul 12 00:00:00 EDT 2023
Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Cellular and molecular life sciences : CMLS
Solomon S,Sampathkumar NK,Carre I,Mondal M,Chennell G,Vernon AC,Ruepp MD,Mitchell JC
120-05ET was used in Sample Preparation to investigate P522R in Alzheimer’s disease.
Wed Jul 27 00:00:00 EDT 2022
SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer.
Oncogene
Frey P,Devisme A,Rose K,Schrempp M,Freihen V,Andrieux G,Boerries M,Hecht A
Tue Feb 01 00:00:00 EST 2022
Human Spinal Organoid-on-a-Chip to Model Nociceptive Circuitry for Pain Therapeutics Discovery.
Analytical chemistry
Ao Z,Cai H,Wu Z,Krzesniak J,Tian C,Lai YY,Mackie K,Guo F
Tue Jan 18 00:00:00 EST 2022
The combined effects of Map3k1 mutation and dioxin on differentiation of keratinocytes derived from mouse embryonic stem cells.
Scientific reports
Wang J,Xiao B,Kimura E,Mongan M,Xia Y
120-05ET was used in Cell Culture to investigate the effects of Map3k1 mutation mESCs on differentiation.
Thu Jul 07 00:00:00 EDT 2022
ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation.
Autophagy
Zhou J,He H,Zhang JJ,Liu X,Yao W,Li C,Xu T,Yin SY,Wu DY,Dou CL,Li Q,Xiang J,Xiong WJ,Wang LY,Tang JM,Xue Z,Zhang X,Miao YL
120-05ET was used in Cell Culture to reveal that autophagy-dependent degradation of NANOG plays a critical role in regulating exit from the naive state and marks distinct cell fate allocation during lineage specification.
Thu Dec 01 00:00:00 EST 2022
Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells.
Stem cell research & therapy
Song C,Wang L,Li Q,Liao B,Qiao W,Li Q,Dong N,Li L
120-05ET was used in In vitro experiments to generate HLA-matched iPSCs based on patient's HLA genotyping by HLA exchanging approach to express the required HLA allele.
Wed Feb 02 00:00:00 EST 2022
Glutamine-dependent signaling controls pluripotent stem cell fate.
Developmental cell
Lu V,Roy IJ,Torres A,Joly JH,Ahsan FM,Graham NA,Teitell MA
120-05ET was used in Cell Culture to suggest that intracellular Gln may help coordinate differentiation of the three germ layers.
Mon Mar 14 00:00:00 EDT 2022
Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis.
mBio
Santucci P,Aylan B,Botella L,Bernard EM,Bussi C,Pellegrino E,Athanasiadi N,Gutierrez MG
120-05ET was used in Cell Culture to describe a dual live imaging approach to monitor mycobacterial pH homeostasis, host cell environment, and antibiotic action, and show that intracellular localization of M. tuberculosis affects the efficacy of pyrazinamide.
Tue Apr 26 00:00:00 EDT 2022
Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.
STAR protocols
Martinez-Silgado A,Yousef Yengej FA,Puschhof J,Geurts V,Boot C,Geurts MH,Rookmaaker MB,Verhaar MC,Beumer J,Clevers H
120-05ET was used in In vitro experiments to investigate the effects of BMP agonists on differentiation of human small intestinal organoids.
Fri Sep 16 00:00:00 EDT 2022
A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling.
Carcinogenesis
Zhao L,Lei J,Gu S,Zhang Y,Jing X,Wang L,Zhang L,Ning Q,Luo M,Qi Y,Zhao X,Shao S
120-05ET was used in Cell Culture to indicate that the YAP1-Notch1 positive feedback loop promotes lung metastasis of breast cancer by modulating self-renewal and inhibiting the BMP4-SMAD1/5 signaling.
Sat Dec 31 00:00:00 EST 2022
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Cell stem cell
Jin M,Xu R,Wang L,Alam MM,Ma Z,Zhu S,Martini AC,Jadali A,Bernabucci M,Xie P,Kwan KY,Pang ZP,Head E,Liu Y,Hart RP,Jiang P
120-05ET was used in Cell Culture to provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.
Thu Jul 07 00:00:00 EDT 2022
Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5.
Nature cancer
Sun Y,Yan K,Wang Y,Xu C,Wang D,Zhou W,Guo S,Han Y,Tang L,Shao Y,Shan S,Zhang QC,Tang Y,Zhang L,Xi Q
120-05ET was used in In vitro experiments to show how BMP signaling impacts diffuse intrinsic pontine glioma (DIPG) and identifies the potent antitumor efficacy of Dacinostat for DIPG.
Thu Sep 01 00:00:00 EDT 2022
A splicing factor switch controls hematopoietic lineage specification of pluripotent stem cells.
EMBO reports
Li Y,Wang D,Wang H,Huang X,Wen Y,Wang B,Xu C,Gao J,Liu J,Tong J,Wang M,Su P,Ren S,Ma F,Li HD,Bresnick EH,Zhou J,Shi L
Thu Jan 07 00:00:00 EST 2021
HiPS-Endothelial Cells Acquire Cardiac Endothelial Phenotype in Co-culture With hiPS-Cardiomyocytes.
Frontiers in cell and developmental biology
Helle E,Ampuja M,Dainis A,Antola L,Temmes E,Tolvanen E,Mervaala E,Kivelä R
120-05ET was used in Cell Culture to study the organotypic development of cardiac endothelial cells (ECs) and cardiomyocyte (CM)-EC crosstalk using human induced pluripotent stem cells (hiPSC) to investigate bidirectional communication of cells in the heart and demonstrate the importance of EC-CM interactions for development.
Tue Aug 24 00:00:00 EDT 2021
SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells.
Stem cells (Dayton, Ohio)
Djidrovski I,Georgiou M,Hughes GL,Patterson EI,Casas-Sanchez A,Pennington SH,Biagini GA,Moya-Molina M,van den Bor J,Smit MJ,Chung G,Lako M,Armstrong L
Fri Oct 01 00:00:00 EDT 2021
Modeling human-specific interlaminar astrocytes in the mouse cerebral cortex.
The Journal of comparative neurology
Padmashri R,Ren B,Oldham B,Jung Y,Gough R,Dunaevsky A
Mon Mar 01 00:00:00 EST 2021
Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients.
Translational psychiatry
Heard KJ,Shokhirev MN,Becronis C,Fredlender C,Zahid N,Le AT,Ji Y,Skime M,Nelson T,Hall-Flavin D,Weinshilboum R,Gage FH,Vadodaria KC
Tue Nov 30 00:00:00 EST 2021
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Science advances
Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG
120-05ET was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).
Fri Jan 01 00:00:00 EST 2021
Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation.
Hepatology (Baltimore, Md.)
Peaslee C,Esteva-Font C,Su T,Munoz-Howell A,Duwaerts CC,Liu Z,Rao S,Liu K,Medina M,Sneddon JB,Maher JJ,Mattis AN
120-05ET was used in In vitro experiments to test this protocol in >70 iPSC lines, 90% of which consistently formed complete sheets of endoderm.
Fri Oct 01 00:00:00 EDT 2021
A protocol for transdifferentiation of human cardiac fibroblasts into endothelial cells via activation of innate immunity.
STAR protocols
Liu C,Medina P,Thomas D,Chen IY,Sallam K,Sayed D,Sayed N
120-05ET was used in In vitro experiments to investigate endothelial cell derivation from induced pluripotent stem cells.
Fri Jun 18 00:00:00 EDT 2021
Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation.
The Journal of biological chemistry
Krantz S,Kim YM,Srivastava S,Leasure JW,Toth PT,Marsboom G,Rehman J
Wed Dec 01 00:00:00 EST 2021
SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.
Cell reports
Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II
120-05ET was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.
Tue Feb 16 00:00:00 EST 2021
LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.
Communications biology
Herdenberg C,Mutie PM,Billing O,Abdullah A,Strawbridge RJ,Dahlman I,Tuck S,Holmlund C,Arner P,Henriksson R,Franks PW,Hedman H
Tue Jan 19 00:00:00 EST 2021
Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells.
Cell reports
Kobayashi T,Castillo-Venzor A,Penfold CA,Morgan M,Mizuno N,Tang WWC,Osada Y,Hirao M,Yoshida F,Sato H,Nakauchi H,Hirabayashi M,Surani MA
Tue Oct 12 00:00:00 EDT 2021
EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.
Cancers
Bleijs M,Pleijte C,Engels S,Ringnalda F,Meyer-Wentrup F,van de Wetering M,Clevers H
120-05ET was used in Cell Culture to investigate potential treatment for desmoplastic small round cell tumour.
Thu Dec 02 00:00:00 EST 2021
The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development.
Frontiers in immunology
Tsui M,Min W,Ng S,Dobbs K,Notarangelo LD,Dror Y,Grunebaum E
120-05ET was used in Cell Culture to study the characterization of neutrophil developmental abnormalities and the mechanisms contributing to them to demonstrate the important role of adenosine deaminase (ADA) in the development and function of neutrophils while clarifying the mechanisms responsible for the neutrophil abnormalities in ADA-deficient patients.
Mon Dec 27 00:00:00 EST 2021
High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.
Cell
Beumer J,Puschhof J,Bauzá-Martinez J,Martínez-Silgado A,Elmentaite R,James KR,Ross A,Hendriks D,Artegiani B,Busslinger GA,Ponsioen B,Andersson-Rolf A,Saftien A,Boot C,Kretzschmar K,Geurts MH,Bar-Ephraim YE,Pleguezuelos-Manzano C,Post Y,Begthel H,van der Linden F,Lopez-Iglesias C,van de Wetering WJ,van der Linden R,Peters PJ,Heck AJR,Goedhart J,Snippert H,Zilbauer M,Teichmann SA,Wu W,Clevers H
Thu Jun 11 00:00:00 EDT 2020
LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma.
EMBO molecular medicine
Leiendecker L,Jung PS,Krecioch I,Neumann T,Schleiffer A,Mechtler K,Wiesner T,Obenauf AC
Fri Nov 06 00:00:00 EST 2020
Coordination of germ layer lineage choice by TET1 during primed pluripotency.
Genes & development
Luo X,van der Veer BK,Sun L,Bartoccetti M,Boretto M,Vankelecom H,Khoueiry R,Koh KP
120-05ET was used in Cell Culture to study how Tet1 plays a pivotal role upstream of germ layer lineage bifurcation and provide mechanistic information for epigenetic integration of pluripotency and signal-induced differentiation cues.
Wed Apr 01 00:00:00 EDT 2020
Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit+ cardiac interstitial cells.
Stem cells translational medicine
Wang BJ,Alvarez R,Muliono A,Sengphanith S,Monsanto MM,Weeks J,Sacripanti R,Sussman MA
Fri May 01 00:00:00 EDT 2020
Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit+ cardiac interstitial cells.
Stem cells translational medicine
Wang BJ,Alvarez R,Muliono A,Sengphanith S,Monsanto MM,Weeks J,Sacripanti R,Sussman MA
Fri May 01 00:00:00 EDT 2020
Long-Term Expansion of Functional Human Pluripotent Stem Cell-Derived Hepatic Organoids.
International journal of stem cells
Mun SJ,Hong YH,Ahn HS,Ryu JS,Chung KS,Son MJ
120-05ET was used in Cell Culture to test long-term prolonged culture of organoids to increase their maturity to demonstrate that organoids can be exponentially expanded by serial passaging, while maintaining long-term functional maturation potential, hence are a practical and renewable cell source for human cell-based and personalized 3D liver models.
Thu Jul 30 00:00:00 EDT 2020
The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs.
Nature communications
Zorzan I,Pellegrini M,Arboit M,Incarnato D,Maldotti M,Forcato M,Tagliazucchi GM,Carbognin E,Montagner M,Oliviero S,Martello G
Tue May 12 00:00:00 EDT 2020
Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives.
Scientific reports
Jo HY,Han HW,Jung I,Ju JH,Park SJ,Moon S,Geum D,Kim H,Park HJ,Kim S,Stacey GN,Koo SK,Park MH,Kim JH
Tue Mar 03 00:00:00 EST 2020
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.
Cell reports
Rexach JE,Polioudakis D,Yin A,Swarup V,Chang TS,Nguyen T,Sarkar A,Chen L,Huang J,Lin LC,Seeley W,Trojanowski JQ,Malhotra D,Geschwind DH
120-05ET was used in In vitro experiments to investigate gene analysis in neurodegenerative diseases.
Tue Nov 17 00:00:00 EST 2020
Generation of Vascularized Neural Organoids by Co-culturing with Mesodermal Progenitor Cells.
STAR protocols
Wörsdörfer P,Rockel A,Alt Y,Kern A,Ergün S
120-05ET was used in In vitro experiments to describe a protocol to incorporate stromal components, first of all blood vessels, by co-culturing with induced pluripotent stem cell-derived mesodermal progenitor cells.
Fri Jun 19 00:00:00 EDT 2020
Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.
Bio-protocol
Chen IP
120-05ET was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.
Sun Dec 20 00:00:00 EST 2020
Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells.
Current protocols in immunology
Pleguezuelos-Manzano C,Puschhof J,van den Brink S,Geurts V,Beumer J,Clevers H
120-05ET was used in Cell Culture to provide a basic guide to establishment and maintenance of human intestinal organoids derived from small intestine and colon biopsies and provide an overview of several downstream applications of human intestinal organoids.
Tue Sep 01 00:00:00 EDT 2020
microRNA-181c-5p promotes the formation of insulin-producing cells from human induced pluripotent stem cells by targeting smad7 and TGIF2.
Cell death & disease
Li N,Jiang D,He Q,He F,Li Y,Deng C,Li F
Mon Jun 15 00:00:00 EDT 2020
iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome.
Stem cell reports
Atchison L,Abutaleb NO,Snyder-Mounts E,Gete Y,Ladha A,Ribar T,Cao K,Truskey GA
Tue Feb 11 00:00:00 EST 2020
Adult Tissue Extracellular Matrix Determines Tissue Specification of Human iPSC-Derived Embryonic Stage Mesodermal Precursor Cells.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Ullah I,Busch JF,Rabien A,Ergün B,Stamm C,Knosalla C,Hippenstiel S,Reinke P,Kurtz A
Sun Mar 01 00:00:00 EST 2020
Endothelial Progenitor Cells Produced From Human Pluripotent Stem Cells by a Synergistic Combination of Cytokines, Small Compounds, and Serum-Free Medium.
Frontiers in cell and developmental biology
Farkas S,Simara P,Rehakova D,Veverkova L,Koutna I
120-05ET was used in In vitro experiments to devise a robust three-phase protocol exploiting the synergy of multiple differentiation effector to efficently convert hPSCs into EPCs.
Mon Sep 28 00:00:00 EDT 2020
TGF-β-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane.
Scientific reports
Kanda A,Noda K,Hirose I,Ishida S
Thu Jan 24 00:00:00 EST 2019
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death.
Scientific reports
Ajmone-Cat MA,Onori A,Toselli C,Stronati E,Morlando M,Bozzoni I,Monni E,Kokaia Z,Lupo G,Minghetti L,Biagioni S,Cacci E
Thu Mar 14 00:00:00 EDT 2019
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.
Scientific reports
Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II
Mon Apr 29 00:00:00 EDT 2019
Functional characterization of iPSC-derived arterial- and venous-like endothelial cells.
Scientific reports
Rosa S,Praça C,Pitrez PR,Gouveia PJ,Aranguren XL,Ricotti L,Ferreira LS
Thu Mar 07 00:00:00 EST 2019
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.
Communications biology
Carvalho D,Taylor KR,Olaciregui NG,Molinari V,Clarke M,Mackay A,Ruddle R,Henley A,Valenti M,Hayes A,Brandon AH,Eccles SA,Raynaud F,Boudhar A,Monje M,Popov S,Moore AS,Mora J,Cruz O,Vinci M,Brennan PE,Bullock AN,Carcaboso AM,Jones C
Mon Apr 20 00:00:00 EDT 2020
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.
Cell
Nanki K,Toshimitsu K,Takano A,Fujii M,Shimokawa M,Ohta Y,Matano M,Seino T,Nishikori S,Ishikawa K,Kawasaki K,Togasaki K,Takahashi S,Sukawa Y,Ishida H,Sugimoto S,Kawakubo H,Kim J,Kitagawa Y,Sekine S,Koo BK,Kanai T,Sato T
Thu Aug 09 00:00:00 EDT 2018
Rapid and efficient induction of functional astrocytes from human pluripotent stem cells.
Nature methods
Canals I,Ginisty A,Quist E,Timmerman R,Fritze J,Miskinyte G,Monni E,Hansen MG,Hidalgo I,Bryder D,Bengzon J,Ahlenius H
Sat Sep 01 00:00:00 EDT 2018
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Neuron
Lin YT,Seo J,Gao F,Feldman HM,Wen HL,Penney J,Cam HP,Gjoneska E,Raja WK,Cheng J,Rueda R,Kritskiy O,Abdurrob F,Peng Z,Milo B,Yu CJ,Elmsaouri S,Dey D,Ko T,Yankner BA,Tsai LH
Wed Jun 27 00:00:00 EDT 2018
MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.
Stem cell reports
Wang H,Liu C,Liu X,Wang M,Wu D,Gao J,Su P,Nakahata T,Zhou W,Xu Y,Shi L,Ma F,Zhou J
Tue Feb 13 00:00:00 EST 2018
Preserving self-renewal of porcine pluripotent stem cells in serum-free 3i culture condition and independent of LIF and b-FGF cytokines.
Cell death discovery
Ma Y,Yu T,Cai Y,Wang H
Sat Dec 01 00:00:00 EST 2018
NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.
JCI insight
Barruet E,Morales BM,Cain CJ,Ton AN,Wentworth KL,Chan TV,Moody TA,Haks MC,Ottenhoff TH,Hellman J,Nakamura MC,Hsiao EC
120-05ET was used in In vitro experiments to examine the potential link between bone morphogenetic proteins and inflammation in patients with fibrodysplasia ossificans progressiva.
Thu Nov 15 00:00:00 EST 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 EDT 2018
Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents.
PloS one
Southard SM,Kotipatruni RP,Rust WL
120-05ET was used in In vitro experiments to show that SR1423 is a candidate cell line for the production of insulin-producing cells useful for the treatment of diabetes.
Thu Feb 21 00:00:00 EST 2019
Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
PloS one
Sambathkumar R,Akkerman R,Dastidar S,Roelandt P,Kumar M,Bajaj M,Mestre Rosa AR,Helsen N,Vanslembrouck V,Kalo E,Khurana S,Laureys J,Gysemans C,Faas MM,de Vos P,Verfaillie CM
120-05ET was used in Cell Culture to investigate 14 transcription factors in multipotent adult progenitor cell reprogramming for hepatocyte and endocrine pacreatic-like cell culture.
Tue Jul 31 00:00:00 EDT 2018
TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.
eLife
Ramachandran A,Vizán P,Das D,Chakravarty P,Vogt J,Rogers KW,Müller P,Hinck AP,Sapkota GP,Hill CS
120-05ET was used in Cell Culture to show that TGF-β-induced epithelial-to-mesenchymal transition requires signaling via both the SMAD3 and SMAD1/5 pathways, with SMAD1/5 signaling being essential to induce ID1.
Mon Jan 29 00:00:00 EST 2018
BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells.
Scientific reports
Armenteros T,Andreu Z,Hortigüela R,Lie DC,Mira H
Mon Jun 18 00:00:00 EDT 2018
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.
Neuron
Petersen MA,Ryu JK,Chang KJ,Etxeberria A,Bardehle S,Mendiola AS,Kamau-Devers W,Fancy SPJ,Thor A,Bushong EA,Baeza-Raja B,Syme CA,Wu MD,Rios Coronado PE,Meyer-Franke A,Yahn S,Pous L,Lee JK,Schachtrup C,Lassmann H,Huang EJ,Han MH,Absinta M,Reich DS,Ellisman MH,Rowitch DH,Chan JR,Akassoglou K
Wed Dec 06 00:00:00 EST 2017
Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells.
Stem cell research & therapy
Li Y,Wen Y,Green M,Cabral EK,Wani P,Zhang F,Wei Y,Baer TM,Chen B
120-05ET was used in Cell Culture to explore differences in stem cell differentiation between male and female human pluripotent stem cells (hPSCs) and the effect of oestrogen on hPSC-derived smooth muscle progenitor cells.
Tue Jul 04 00:00:00 EDT 2017
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.
Nature communications
Shan Y,Liang Z,Xing Q,Zhang T,Wang B,Tian S,Huang W,Zhang Y,Yao J,Zhu Y,Huang K,Liu Y,Wang X,Chen Q,Zhang J,Shang B,Li S,Shi X,Liao B,Zhang C,Lai K,Zhong X,Shu X,Wang J,Yao H,Chen J,Pei D,Pan G
120-05ET was used in Sample Preparation (FC/FACS) to study the roles of Polycomb repressive complex 2 and the epigenetic mark that it deposits, H3K27me3, in cell fate decisions in early embryonic development.
Fri Sep 22 00:00:00 EDT 2017
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.
Nature communications
Shan Y,Liang Z,Xing Q,Zhang T,Wang B,Tian S,Huang W,Zhang Y,Yao J,Zhu Y,Huang K,Liu Y,Wang X,Chen Q,Zhang J,Shang B,Li S,Shi X,Liao B,Zhang C,Lai K,Zhong X,Shu X,Wang J,Yao H,Chen J,Pei D,Pan G
120-05ET was used in Sample Preparation (FC/FACS) to study the roles of Polycomb repressive complex 2 and the epigenetic mark that it deposits, H3K27me3, in cell fate decisions in early embryonic development.
Fri Sep 22 00:00:00 EDT 2017
Growth factors regulate phospholipid biosynthesis in human fibroblast-like synoviocytes obtained from osteoarthritic knees.
Scientific reports
Sluzalska KD,Liebisch G,Wilhelm J,Ishaque B,Hackstein H,Schmitz G,Rickert M,Steinmeyer J
Wed Oct 18 00:00:00 EDT 2017
Development of Hepatocyte-like Cell Derived from Human Induced Pluripotent Stem cell as a Host for Clinically Isolated Hepatitis C Virus.
Current protocols in stem cell biology
Sa-Ngiamsuntorn K,Hongeng S,Wongkajornsilp A
120-05ET was used in In vitro experiments to devise protocols to generate hepatocyte-like cells from mesenchymal stem cells, with the ability to host hepatitis C virus clinical isolate or conventional JFH-1 genotype.
Mon Aug 14 00:00:00 EDT 2017
Differentiation of Mouse Embryonic Stem Cells into Ventral Foregut Precursors.
Current protocols in stem cell biology
Rothová M,Hölzenspies JJ,Livigni A,Villegas SN,Brickman JM
120-05ET was used in Cell Culture to describe a method for the differentiation of mouse embryonic stem cells (mESCs) to definitive endoderm with pronounced anterior character.
Wed Feb 03 00:00:00 EST 2016
H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro.
Stem cell reports
Vanhove J,Pistoni M,Welters M,Eggermont K,Vanslembrouck V,Helsen N,Boon R,Najimi M,Sokal E,Collas P,Voncken JW,Verfaillie CM
Tue Aug 09 00:00:00 EDT 2016
Genome-Wide Identification of MESP1 Targets Demonstrates Primary Regulation Over Mesendoderm Gene Activity.
Stem cells (Dayton, Ohio)
Soibam B,Benham A,Kim J,Weng KC,Yang L,Xu X,Robertson M,Azares A,Cooney AJ,Schwartz RJ,Liu Y
Sun Nov 01 00:00:00 EDT 2015
Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors.
Nature biotechnology
Maza I,Caspi I,Zviran A,Chomsky E,Rais Y,Viukov S,Geula S,Buenrostro JD,Weinberger L,Krupalnik V,Hanna S,Zerbib M,Dutton JR,Greenleaf WJ,Massarwa R,Novershtern N,Hanna JH
120-05ET was used in Cell Culture to show that the vast majority of reprogrammed cardiomyocytes or neural stem cells obtained from mouse fibroblasts by OSKM-induced 'transdifferentiation' pass through a transient pluripotent state, and that their derivation is molecularly coupled to iPSC formation mechanisms.
Wed Jul 01 00:00:00 EDT 2015
Noggin recruits mesoderm progenitors from the dorsal aorta to a skeletal myogenic fate.
Developmental biology
Ugarte G,Cappellari O,Perani L,Pistocchi A,Cossu G
Tue May 01 00:00:00 EDT 2012
Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair.
PloS one
Sountoulidis A,Stavropoulos A,Giaglis S,Apostolou E,Monteiro R,Chuva de Sousa Lopes SM,Chen H,Stripp BR,Mummery C,Andreakos E,Sideras P
Wed May 15 00:00:00 EDT 2013
Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells.
PloS one
Rodríguez-Martínez G,Molina-Hernández A,Velasco I
Tue Jan 29 00:00:00 EST 2013
Fstl1 antagonizes BMP signaling and regulates ureter development.
PloS one
Xu J,Qi X,Gong J,Yu M,Zhang F,Sha H,Gao X
Fri Jul 27 00:00:00 EDT 2012
Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells.
Blood
Joo HJ,Kim H,Park SW,Cho HJ,Kim HS,Lim DS,Chung HM,Kim I,Han YM,Koh GY
Thu Aug 25 00:00:00 EDT 2011
Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells.
Stem cells (Dayton, Ohio)
Iacovino M,Bosnakovski D,Fey H,Rux D,Bajwa G,Mahen E,Mitanoska A,Xu Z,Kyba M
Sat Oct 01 00:00:00 EDT 2011
