Gibco

Human CCL18 (MIP-4) Recombinant Protein, PeproTech®

Product Details

300-34-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 14 publications 14 publications

Miscellaneous PubMed (Misc)

View 5 publications 5 publications

Product Specifications

Species

Human

Published species

Bacteria, Human, Mouse

Expression System

E. coli

Amino acid sequence

QVGTNKELCC LVYTSWQIPQ KFIVDYSETS PQCPKPGVIL LTKRGRQICA DPNKKWVQKY ISDLKLNA

Molecular weight

7.8 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human MIP-4 is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Macrophage Inflammatory Protein-4 (MIP-4), also called CCL18, is a chemokine expressed in the lymph nodes, lungs, placenta and bone marrow. Although the MIP-4s receptor remains undetermined, MIP-4 is known to act as a chemoattractant for activated and non-activated T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction.

The Journal of biological chemistry

Darlot B,Eaton JRO,Geis-Asteggiante L,Yakala GK,Karuppanan K,Davies G,Robinson CV,Kawamura A,Bhattacharya S

Fri Aug 07 00:00:00 EDT 2020

CCL18-induced LINC00319 promotes proliferation and metastasis in oral squamous cell carcinoma via the miR-199a-5p/FZD4 axis.

Cell death & disease

Jiang X,Liu J,Li S,Jia B,Huang Z,Shen J,Luo H,Zhao J

Fri Sep 18 00:00:00 EDT 2020

ARNT-dependent CCR8 reprogrammed LDH isoform expression correlates with poor clinical outcomes of prostate cancer.

Molecular carcinogenesis

Chen G,Cai ZD,Lin ZY,Wang C,Liang YX,Han ZD,He HC,Mo RJ,Lu JM,Pan B,Wu CL,Wang F,Zhong WD

300-34 was used in Cell Culture to indicate that the CCR8 pathway programs LDH isoform expression in an ARNT dependent manner and that the ratio of LDHA/LDHB has the potential to serve as biomarkers for PCa diagnosis and prognosis.

Sat Aug 01 00:00:00 EDT 2020

PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.

The Journal of clinical investigation

Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C

Fri Mar 01 00:00:00 EST 2019

Increased Plasma Levels of the TH2 chemokine CCL18 associated with low CD4+ T cell counts in HIV-1-infected Patients with a Suppressed Viral Load.

Scientific reports

Malhotra P,Haslett P,Sherry B,Shepp DH,Barber P,Abshier J,Roy U,Schmidtmayerova H

Fri Apr 12 00:00:00 EDT 2019

A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.

The Journal of biological chemistry

Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S

Fri Jul 19 00:00:00 EDT 2019

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Cell

Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E

300-34 was used in In vitro experiments to report here an unexpected finding that macrophages after antibody-dependent cellular cytotoxicity inhibit NK cell-mediated antibody-dependent cellular cytotoxicity and T cell-mediated cytotoxicity in breast cancers and lymphomas.

Thu Oct 04 00:00:00 EDT 2018

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.

Scientific reports

Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S

Fri Apr 20 00:00:00 EDT 2018

Blocking the recruitment of naive CD4⁺ T cells reverses immunosuppression in breast cancer.

Cell research

Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E

Sat Apr 01 00:00:00 EDT 2017

Blocking the recruitment of naive CD4⁺ T cells reverses immunosuppression in breast cancer.

Cell research

Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E

Sat Apr 01 00:00:00 EDT 2017

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.

Neuron

Abud EM,Ramirez RN,Martinez ES,Healy LM,Nguyen CHH,Newman SA,Yeromin AV,Scarfone VM,Marsh SE,Fimbres C,Caraway CA,Fote GM,Madany AM,Agrawal A,Kayed R,Gylys KH,Cahalan MD,Cummings BJ,Antel JP,Mortazavi A,Carson MJ,Poon WW,Blurton-Jones M

Wed Apr 19 00:00:00 EDT 2017

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Scientific reports

Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S

Tue Jun 27 00:00:00 EDT 2017

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.

Scientific reports

Yagawa Y,Robertson-Tessi M,Zhou SL,Anderson ARA,Mulé JJ,Mailloux AW

Wed Nov 22 00:00:00 EST 2017

Reprogramming of monocytes by GM-CSF contributes to regulatory immune functions during intestinal inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Däbritz J,Weinhage T,Varga G,Wirth T,Walscheid K,Brockhausen A,Schwarzmaier D,Brückner M,Ross M,Bettenworth D,Roth J,Ehrchen JM,Foell D

Sun Mar 01 00:00:00 EST 2015

A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.

Cancer cell

Su S,Liu Q,Chen J,Chen J,Chen F,He C,Huang D,Wu W,Lin L,Huang W,Zhang J,Cui X,Zheng F,Li H,Yao H,Su F,Song E

Mon May 12 00:00:00 EDT 2014

Host chemokines bind to Staphylococcus aureus and stimulate protein A release.

The Journal of biological chemistry

Yung SC,Parenti D,Murphy PM

Fri Feb 18 00:00:00 EST 2011

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS pathogens

Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM

Tue Jan 01 00:00:00 EST 2008

CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Günther C,Bello-Fernandez C,Kopp T,Kund J,Carballido-Perrig N,Hinteregger S,Fassl S,Schwärzler C,Lametschwandtner G,Stingl G,Biedermann T,Carballido JM

Tue Feb 01 00:00:00 EST 2005

CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Günther C,Bello-Fernandez C,Kopp T,Kund J,Carballido-Perrig N,Hinteregger S,Fassl S,Schwärzler C,Lametschwandtner G,Stingl G,Biedermann T,Carballido JM

Tue Feb 01 00:00:00 EST 2005

C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap.

Journal of immunology (Baltimore, Md. : 1950)

Nibbs RJ,Salcedo TW,Campbell JD,Yao XT,Li Y,Nardelli B,Olsen HS,Morris TS,Proudfoot AE,Patel VP,Graham GJ

Tue Feb 01 00:00:00 EST 2000

Bioinformatics

Protein Aliases: Alternative macrophage activation-associated CC chemokine 1; AMAC-1; C-C motif chemokine 18; CC chemokine ligand 18; CC chemokine PARC; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated); chemokine (C-C), dendritic; DC-CK1; Dendritic cell chemokine 1; H-MIP-4; Macrophage inflammatory protein 4; MIP-4; Pulmonary and activation-regulated chemokine; small inducible cytokine A18; small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated; Small-inducible cytokine A18

View more View less

Gene Aliases: AMAC-1; AMAC1; CCL18; CKb7; DC-CK1; DCCK1; MIP-4; MIP4; PARC; SCYA18

Human CCL18 (MIP-4) Recombinant Protein, PeproTech®

Product Details

300-34-10UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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