Product References
Deterministic nuclear reprogramming of mammalian nuclei to a totipotency-like state by Amphibian meiotic oocytes for stem cell therapy in humans.
Biology open
Wen MH,Barbosa Triana H,Butler R,Hu HW,Dai YH,Lawrence N,Hong JJ,Garrett N,Jones-Green R,Rawlins EL,Dong Z,Koziol MJ,Gurdon JB
450-13 was used in Cell Culture to conclude that much of the reprogramming effect of eggs is already present in meiotic oocytes and does not require cell division or selection of dividing cells.
Fri Mar 01 00:00:00 EST 2024
Asymmetric charge balanced waveforms direct retinal ganglion cell axon growth.
Scientific reports
Peng MG,Iseri E,Simonyan A,Lam P,Kim T,Medvidovic S,Paknahad J,Machnoor M,Lazzi G,Gokoffski KK
450-13 was used in Tissue/organ culture to demonstrate the relative influence of pulse amplitude and pulse width on the overall effectiveness of stimulation.
Mon Aug 14 00:00:00 EDT 2023
Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte-derived lipid transport.
Journal of neurochemistry
Mok KK,Yeung SH,Cheng GW,Ma IW,Lee RH,Herrup K,Tse KH
450-13 was used in In vitro experiments to propose that high myelin turnover and OL exhaustion found in APOE4 carriers is a likely explanation for the APOE-dependent myelin phenotypes of the AD brain.
Sat Apr 01 00:00:00 EDT 2023
An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming.
Science advances
Weng M,Hu H,Graus MS,Tan DS,Gao Y,Ren S,Ho DHH,Langer J,Holzner M,Huang Y,Ling GS,Lai CSW,Francois M,Jauch R
450-13 was used in In vitro experiments to report iNSC reprogramming from embryonic and aged mouse fibroblasts as well as from human blood using an engineered Sox17 (eSox17FNV).
Fri Aug 25 00:00:00 EDT 2023
Higher throughput workflow with sensitive, reliable and automatic quantification of myelination in vitro suitable for drug screening.
Scientific reports
Seiler S,Wälti CM,de Barros V,Barbash S,Foo LC
450-13 was used in Cell Culture to develop a method allowing systematic and reliable testing of remyelinating compound efficacy.
Sat Feb 18 00:00:00 EST 2023
Foxa2 and Pet1 Direct and Indirect Synergy Drive Serotonergic Neuronal Differentiation.
Frontiers in neuroscience
Aydin B,Sierk M,Moreno-Estelles M,Tejavibulya L,Kumar N,Flames N,Mahony S,Mazzoni EO
450-13 was used in In vitro experiments to highlight the challenges in formulating generalizable rules for describing the behavior of TF combinations that program distinct neuronal subtypes.
Tue Aug 30 00:00:00 EDT 2022
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.
Cancer cell
Haag D,Mack N,Benites Goncalves da Silva P,Statz B,Clark J,Tanabe K,Sharma T,Jäger N,Jones DTW,Kawauchi D,Wernig M,Pfister SM
Mon Mar 08 00:00:00 EST 2021
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs.
Cell stem cell
Cates K,McCoy MJ,Kwon JS,Liu Y,Abernathy DG,Zhang B,Liu S,Gontarz P,Kim WK,Chen S,Kong W,Ho JN,Burbach KF,Gabel HW,Morris SA,Yoo AS
450-13 was used in Sample Preparation to study the activity of microRNAs miR-9/9∗ and miR-124 (miR-9/9∗-124) as reprogramming agents which rchestrate direct conversion of human fibroblasts into motor neurons.
Thu Jan 07 00:00:00 EST 2021
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs.
Cell stem cell
Cates K,McCoy MJ,Kwon JS,Liu Y,Abernathy DG,Zhang B,Liu S,Gontarz P,Kim WK,Chen S,Kong W,Ho JN,Burbach KF,Gabel HW,Morris SA,Yoo AS
450-13 was used in Sample Preparation to study the activity of microRNAs miR-9/9∗ and miR-124 (miR-9/9∗-124) as reprogramming agents which rchestrate direct conversion of human fibroblasts into motor neurons.
Thu Jan 07 00:00:00 EST 2021
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.
Neuron
Lagomarsino VN,Pearse RV,Liu L,Hsieh YC,Fernandez MA,Vinton EA,Paull D,Felsky D,Tasaki S,Gaiteri C,Vardarajan B,Lee H,Muratore CR,Benoit CR,Chou V,Fancher SB,He A,Merchant JP,Duong DM,Martinez H,Zhou M,Bah F,Vicent MA,Stricker JMS,Xu J,Dammer EB,Levey AI,Chibnik LB,Menon V,Seyfried NT,De Jager PL,Noggle S,Selkoe DJ,Bennett DA,Young-Pearse TL
Wed Nov 03 00:00:00 EDT 2021
Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction.
Brain : a journal of neurology
Van Lent J,Verstraelen P,Asselbergh B,Adriaenssens E,Mateiu L,Verbist C,De Winter V,Eggermont K,Van Den Bosch L,De Vos WH,Timmerman V
450-13 was used in Cell Culture to reveal shared cellular phenotypes across different CMT2 subtypes and suggests that targeting such common pathomechanisms could allow the development of a uniform treatment for CMT2.
Sat Sep 04 00:00:00 EDT 2021
A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury.
Stem cells translational medicine
Kamata Y,Isoda M,Sanosaka T,Shibata R,Ito S,Okubo T,Shinozaki M,Inoue M,Koya I,Shibata S,Shindo T,Matsumoto M,Nakamura M,Okano H,Nagoshi N,Kohyama J
Mon Mar 01 00:00:00 EST 2021
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition.
Stem cell reports
Stoklund Dittlau K,Krasnow EN,Fumagalli L,Vandoorne T,Baatsen P,Kerstens A,Giacomazzi G,Pavie B,Rossaert E,Beckers J,Sampaolesi M,Van Damme P,Van Den Bosch L
Tue Sep 14 00:00:00 EDT 2021
SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells.
Cell death & disease
Lai X,Liu J,Zou Z,Wang Y,Wang Y,Liu X,Huang W,Ma Y,Chen Q,Li F,Wu G,Li W,Wang W,Yuan Y,Jiang B
Fri Aug 27 00:00:00 EDT 2021
Cilium induction triggers differentiation of glioma stem cells.
Cell reports
Goranci-Buzhala G,Mariappan A,Ricci-Vitiani L,Josipovic N,Pacioni S,Gottardo M,Ptok J,Schaal H,Callaini G,Rajalingam K,Dynlacht B,Hadian K,Papantonis A,Pallini R,Gopalakrishnan J
Tue Sep 07 00:00:00 EDT 2021
Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated.
Scientific reports
Singh T,Jiao Y,Ferrando LM,Yablonska S,Li F,Horoszko EC,Lacomis D,Friedlander RM,Carlisle DL
Thu Sep 23 00:00:00 EDT 2021
Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia.
Complex psychiatry
Dobrindt K,Zhang H,Das D,Abdollahi S,Prorok T,Ghosh S,Weintraub S,Genovese G,Powell SK,Lund A,Akbarian S,Eggan K,McCarroll S,Duan J,Avramopoulos D,Brennand KJ
450-13 was used in In vitro experiments to report a standardized resource of publicly available hiPSCs on which we hope to perform genome engineering and generate diverse kinds of functional data, with comparisons across studies facilitated by the use of a common set of genetic backgrounds.
Mon Feb 01 00:00:00 EST 2021
Deep learning-based predictive identification of neural stem cell differentiation.
Nature communications
Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R
450-13 was used in In vitro experiments to showcase effectiveness of deep learning-based platform in precisely, accurately and robustly detecting NSC differentiation.
Mon May 10 00:00:00 EDT 2021
Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons.
Journal of visualized experiments : JoVE
Taga A,Habela CW,Johns A,Liu S,O'Brien M,Maragakis NJ
450-13 was used in Cell Culture to describe a method to co-culture spinal cord hiPSC-A with hiPSC-MN and record electrophysiological activity using MEA recordings.
Thu Aug 26 00:00:00 EDT 2021
Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder.
Nature communications
Kour S,Rajan DS,Fortuna TR,Anderson EN,Ward C,Lee Y,Lee S,Shin YB,Chae JH,Choi M,Siquier K,Cantagrel V,Amiel J,Stolerman ES,Barnett SS,Cousin MA,Castro D,McDonald K,Kirmse B,Nemeth AH,Rajasundaram D,Innes AM,Lynch D,Frosk P,Collins A,Gibbons M,Yang M,Desguerre I,Boddaert N,Gitiaux C,Rydning SL,Selmer KK,Urreizti R,Garcia-Oguiza A,Osorio AN,Verdura E,Pujol A,McCurry HR,Landers JE,Agnihotri S,Andriescu EC,Moody SB,Phornphutkul C,Sacoto MJG,Begtrup A,Houlden H,Kirschner J,Schorling D,Rudnik-Schöneborn S,Strom TM,Leiz S,Juliette K,Richardson R,Yang Y,Zhang Y,Wang M,Wang J,Wang X,Platzer K,Donkervoort S,Bönnemann CG,Wagner M,Issa MY,Elbendary HM,Stanley V,Maroofian R,Gleeson JG,Zaki MS,Senderek J,Pandey UB
Fri May 07 00:00:00 EDT 2021
Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder.
Nature communications
Kour S,Rajan DS,Fortuna TR,Anderson EN,Ward C,Lee Y,Lee S,Shin YB,Chae JH,Choi M,Siquier K,Cantagrel V,Amiel J,Stolerman ES,Barnett SS,Cousin MA,Castro D,McDonald K,Kirmse B,Nemeth AH,Rajasundaram D,Innes AM,Lynch D,Frosk P,Collins A,Gibbons M,Yang M,Desguerre I,Boddaert N,Gitiaux C,Rydning SL,Selmer KK,Urreizti R,Garcia-Oguiza A,Osorio AN,Verdura E,Pujol A,McCurry HR,Landers JE,Agnihotri S,Andriescu EC,Moody SB,Phornphutkul C,Sacoto MJG,Begtrup A,Houlden H,Kirschner J,Schorling D,Rudnik-Schöneborn S,Strom TM,Leiz S,Juliette K,Richardson R,Yang Y,Zhang Y,Wang M,Wang J,Wang X,Platzer K,Donkervoort S,Bönnemann CG,Wagner M,Issa MY,Elbendary HM,Stanley V,Maroofian R,Gleeson JG,Zaki MS,Senderek J,Pandey UB
Fri May 07 00:00:00 EDT 2021
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
Cell
Huang W,Bhaduri A,Velmeshev D,Wang S,Wang L,Rottkamp CA,Alvarez-Buylla A,Rowitch DH,Kriegstein AR
450-13 was used in Cell Culture to indicate properties of OPC derivation, proliferation, and dispersion important for human white matter expansion and myelination.
Thu Aug 06 00:00:00 EDT 2020
m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination.
Neuron
Xu H,Dzhashiashvili Y,Shah A,Kunjamma RB,Weng YL,Elbaz B,Fei Q,Jones JS,Li YI,Zhuang X,Ming GL,He C,Popko B
Wed Jan 22 00:00:00 EST 2020
Neurobiological roots of psychopathy.
Molecular psychiatry
Tiihonen J,Koskuvi M,Lähteenvuo M,Virtanen PLJ,Ojansuu I,Vaurio O,Gao Y,Hyötyläinen I,Puttonen KA,Repo-Tiihonen E,Paunio T,Rautiainen MR,Tyni S,Koistinaho J,Lehtonen Š
Tue Dec 01 00:00:00 EST 2020
Conserved metabolite regulation of stress granule assembly via AdoMet.
The Journal of cell biology
Begovich K,Vu AQ,Yeo G,Wilhelm JE
Mon Aug 03 00:00:00 EDT 2020
The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2.
Glia
Jarjour AA,Velichkova AN,Boyd A,Lord KM,Torsney C,Henderson DJ,Ffrench-Constant C
Tue Sep 01 00:00:00 EDT 2020
Decellularized skeletal muscles display neurotrophic effects in three-dimensional organotypic cultures.
Stem cells translational medicine
Raffa P,Scattolini V,Gerli MFM,Perin S,Cui M,De Coppi P,Elvassore N,Caccin P,Luni C,Urciuolo A
Thu Oct 01 00:00:00 EDT 2020
Reprogramming fibroblasts and peripheral blood cells from a C9ORF72 patient: A proof-of-principle study.
Journal of cellular and molecular medicine
Bardelli D,Sassone F,Colombrita C,Volpe C,Gumina V,Peverelli S,Catusi I,Ratti A,Silani V,Bossolasco P
Wed Apr 01 00:00:00 EDT 2020
Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models.
Cell death & disease
de la Fuente S,Sansa A,Hidalgo I,Vivancos N,Romero-Guevara R,Garcera A,Soler RM
Thu Jun 25 00:00:00 EDT 2020
Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models.
Cell death & disease
de la Fuente S,Sansa A,Hidalgo I,Vivancos N,Romero-Guevara R,Garcera A,Soler RM
Thu Jun 25 00:00:00 EDT 2020
The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene.
The Journal of biological chemistry
Byun JS,Oh M,Lee S,Gil JE,Mo Y,Ku B,Kim WK,Oh KJ,Lee EW,Bae KH,Lee SC,Han BS
Fri Sep 25 00:00:00 EDT 2020
New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain.
eLife
Savier EL,Dunbar J,Cheung K,Reber M
450-13 was used in Cell Culture to predict and validate in vivo the visual mapping defects in a well-characterized mouse model to confirm the basic mechanisms of visual map organization.
Wed Sep 30 00:00:00 EDT 2020
Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3'UTR binding.
Scientific reports
Garone MG,Alfano V,Salvatori B,Braccia C,Peruzzi G,Colantoni A,Bozzoni I,Armirotti A,Rosa A
Thu Jul 16 00:00:00 EDT 2020
Optimized culture of retinal ganglion cells and amacrine cells from adult mice.
PloS one
Park YH,Snook JD,Zhuang I,Shen G,Frankfort BJ
450-13 was used in Cell Culture to develop a technique to isolate retinal neurons from adult mice, which can be used to model in vivo neuronal behaviors.
Tue Jan 19 00:00:00 EST 2021
Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice.
Nature communications
Sun J,Huang Y,Gong J,Wang J,Fan Y,Cai J,Wang Y,Qiu Y,Wei Y,Xiong C,Chen J,Wang B,Ma Y,Huang L,Chen X,Zheng S,Huang W,Ke Q,Wang T,Li X,Zhang W,Xiang AP,Li W
Thu Oct 15 00:00:00 EDT 2020
Metabolic alterations in Parkinson's disease astrocytes.
Scientific reports
Sonninen TM,Hämäläinen RH,Koskuvi M,Oksanen M,Shakirzyanova A,Wojciechowski S,Puttonen K,Naumenko N,Goldsteins G,Laham-Karam N,Lehtonen M,Tavi P,Koistinaho J,Lehtonen Š
Wed Sep 02 00:00:00 EDT 2020
Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model.
eLife
Lee H,Lee HY,Lee BE,Gerovska D,Park SY,Zaehres H,Araúzo-Bravo MJ,Kim JI,Ha Y,Schöler HR,Kim JB
450-13 was used in Cell Culture to investigate the use of induced motor neurons to treat spinal cord injury.
Tue Jun 23 00:00:00 EDT 2020
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment.
Cell
Gibson EM,Nagaraja S,Ocampo A,Tam LT,Wood LS,Pallegar PN,Greene JJ,Geraghty AC,Goldstein AK,Ni L,Woo PJ,Barres BA,Liddelow S,Vogel H,Monje M
Thu Jan 10 00:00:00 EST 2019
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Neuron
Geraghty AC,Gibson EM,Ghanem RA,Greene JJ,Ocampo A,Goldstein AK,Ni L,Yang T,Marton RM,Paşca SP,Greenberg ME,Longo FM,Monje M
Wed Jul 17 00:00:00 EDT 2019
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Neuron
Geraghty AC,Gibson EM,Ghanem RA,Greene JJ,Ocampo A,Goldstein AK,Ni L,Yang T,Marton RM,Paşca SP,Greenberg ME,Longo FM,Monje M
Wed Jul 17 00:00:00 EDT 2019
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.
Neuron
Fang MY,Markmiller S,Vu AQ,Javaherian A,Dowdle WE,Jolivet P,Bushway PJ,Castello NA,Baral A,Chan MY,Linsley JW,Linsley D,Mercola M,Finkbeiner S,Lecuyer E,Lewcock JW,Yeo GW
Wed Sep 04 00:00:00 EDT 2019
Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination.
Neuron
Liu Z,Yan M,Liang Y,Liu M,Zhang K,Shao D,Jiang R,Li L,Wang C,Nussenzveig DR,Zhang K,Chen S,Zhong C,Mo W,Fontoura BMA,Zhang L
Wed May 08 00:00:00 EDT 2019
Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions.
Journal of neurochemistry
Zou S,Balinang JM,Paris JJ,Hauser KF,Fuss B,Knapp PE
450-13 was used in Tissue/organ culture to suggest that the effects of Tat on OL viability are dependent on CaMKIIβ-GSK3β interactions, and that increasing CaMKIIβ activity is a potential approach for limiting OL/myelin injury with HIV infection.
Mon Apr 01 00:00:00 EDT 2019
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Human molecular genetics
Baron DM,Matheny T,Lin YC,Leszyk JD,Kenna K,Gall KV,Santos DP,Tischbein M,Funes S,Hayward LJ,Kiskinis E,Landers JE,Parker R,Shaffer SA,Bosco DA
450-13 was used in Cell Culture to suggest that Golgi to ER retrograde transport may be important under conditions of stress and is perturbed upon the expression of disease-linked proteins such as FUS.
Mon Jul 01 00:00:00 EDT 2019
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.
Nature communications
Vandoorne T,Veys K,Guo W,Sicart A,Vints K,Swijsen A,Moisse M,Eelen G,Gounko NV,Fumagalli L,Fazal R,Germeys C,Quaegebeur A,Fendt SM,Carmeliet P,Verfaillie C,Van Damme P,Ghesquière B,De Bock K,Van Den Bosch L
Thu Sep 12 00:00:00 EDT 2019
Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes.
Nature neuroscience
Aydin B,Kakumanu A,Rossillo M,Moreno-Estellés M,Garipler G,Ringstad N,Flames N,Mahony S,Mazzoni EO
450-13 was used in Cell Culture to find that two main vertebrate proneural factors, Ascl1 and neurogenin 2 (Neurog2), induce different neuronal fates by binding to largely different sets of genomic sites, using direct neuronal programming of embryonic stem cells.
Sat Jun 01 00:00:00 EDT 2019
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons.
eLife
An D,Fujiki R,Iannitelli DE,Smerdon JW,Maity S,Rose MF,Gelber A,Wanaselja EK,Yagudayeva I,Lee JY,Vogel C,Wichterle H,Engle EC,Mazzoni EO
450-13 was used in Cell Culture to show an ESC-based platform has identified a superior capacity to maintain a healthy proteome as a possible mechanism to resist ALS-induced neurodegeneration.
Mon Jun 03 00:00:00 EDT 2019
Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy.
Scientific reports
Malik B,Devine H,Patani R,La Spada AR,Hanna MG,Greensmith L
Tue Mar 05 00:00:00 EST 2019
Single-cell qPCR demonstrates that Repsox treatment changes cell fate from endoderm to neuroectoderm and disrupts epithelial-mesenchymal transition.
PloS one
Li Q,Huang Q
450-13 was used in Cell Culture to show that the process of epithelial-to-mesenchymal transition, which is inherent to the process of definitive endoderm differentiation, was also disrupted upon Repsox treatment. Our findings may provide a new approach to produce neural progenitors.
Wed Mar 11 00:00:00 EDT 2020
Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function.
eLife
Gerber D,Ghidinelli M,Tinelli E,Somandin C,Gerber J,Pereira JA,Ommer A,Figlia G,Miehe M,Nägeli LG,Suter V,Tadini V,Sidiropoulos PN,Wessig C,Toyka KV,Suter U
450-13 was used in Cell Culture to study the effects of dynamin 2 deletion on oligodendrocytes and Schwann cells.
Wed Jan 16 00:00:00 EST 2019
Rapid and efficient induction of functional astrocytes from human pluripotent stem cells.
Nature methods
Canals I,Ginisty A,Quist E,Timmerman R,Fritze J,Miskinyte G,Monni E,Hansen MG,Hidalgo I,Bryder D,Bengzon J,Ahlenius H
Sat Sep 01 00:00:00 EDT 2018
Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors.
Neuron
Blanco-Suarez E,Liu TF,Kopelevich A,Allen NJ
Wed Dec 05 00:00:00 EST 2018
Generation of human brain region-specific organoids using a miniaturized spinning bioreactor.
Nature protocols
Qian X,Jacob F,Song MM,Nguyen HN,Song H,Ming GL
Thu Mar 01 00:00:00 EST 2018
Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.
Translational psychiatry
Srikanth P,Lagomarsino VN,Pearse RV,Liao M,Ghosh S,Nehme R,Seyfried N,Eggan K,Young-Pearse TL
Thu Nov 08 00:00:00 EST 2018
Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis.
Nature communications
Daynac M,Chouchane M,Collins HY,Murphy NE,Andor N,Niu J,Fancy SPJ,Stallcup WB,Petritsch CK
Tue Aug 21 00:00:00 EDT 2018
Novel engineered, membrane-localized variants of vascular endothelial growth factor (VEGF) protect retinal ganglion cells: a proof-of-concept study.
Cell death & disease
Shen J,Xiao R,Bair J,Wang F,Vandenberghe LH,Dartt D,Baranov P,Ng YSE
Wed Oct 03 00:00:00 EDT 2018
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis.
Nature communications
Wang H,Guo W,Mitra J,Hegde PM,Vandoorne T,Eckelmann BJ,Mitra S,Tomkinson AE,Van Den Bosch L,Hegde ML
Tue Sep 11 00:00:00 EDT 2018
High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria.
Scientific reports
Yardeni T,Fine R,Joshi Y,Gradus-Pery T,Kozer N,Reichenstein I,Yanowski E,Nevo S,Weiss-Tishler H,Eisenberg-Bord M,Shalit T,Plotnikov A,Barr HM,Perlson E,Hornstein E
Mon Jan 08 00:00:00 EST 2018
Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines.
Stem cell reports
Perriot S,Mathias A,Perriard G,Canales M,Jonkmans N,Merienne N,Meunier C,El Kassar L,Perrier AL,Laplaud DA,Schluep M,Déglon N,Du Pasquier R
Tue Nov 13 00:00:00 EST 2018
JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.
The Journal of clinical investigation
Wang S,Liang K,Hu Q,Li P,Song J,Yang Y,Yao J,Mangala LS,Li C,Yang W,Park PK,Hawke DH,Zhou J,Zhou Y,Xia W,Hung MC,Marks JR,Gallick GE,Lopez-Berestein G,Flores ER,Sood AK,Huang S,Yu D,Yang L,Lin C
Fri Dec 01 00:00:00 EST 2017
JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.
The Journal of clinical investigation
Wang S,Liang K,Hu Q,Li P,Song J,Yang Y,Yao J,Mangala LS,Li C,Yang W,Park PK,Hawke DH,Zhou J,Zhou Y,Xia W,Hung MC,Marks JR,Gallick GE,Lopez-Berestein G,Flores ER,Sood AK,Huang S,Yu D,Yang L,Lin C
Fri Dec 01 00:00:00 EST 2017
Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.
Neuron
Farhy-Tselnicker I,van Casteren ACM,Lee A,Chang VT,Aricescu AR,Allen NJ
Wed Oct 11 00:00:00 EDT 2017
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Neuron
Sloan SA,Darmanis S,Huber N,Khan TA,Birey F,Caneda C,Reimer R,Quake SR,Barres BA,Paşca SP
Wed Aug 16 00:00:00 EDT 2017
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Oncogene
Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW
Thu Jul 13 00:00:00 EDT 2017
Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells.
Stem cells translational medicine
Sluch VM,Chamling X,Liu MM,Berlinicke CA,Cheng J,Mitchell KL,Welsbie DS,Zack DJ
Wed Nov 01 00:00:00 EDT 2017
Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity.
Journal of lipid research
Sun S,Wang R,Song J,Guan M,Li N,Zhang X,Zhao Z,Zhang J
Wed Nov 01 00:00:00 EDT 2017
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.
Stem cell reports
Oksanen M,Petersen AJ,Naumenko N,Puttonen K,Lehtonen Š,Gubert Olivé M,Shakirzyanova A,Leskelä S,Sarajärvi T,Viitanen M,Rinne JO,Hiltunen M,Haapasalo A,Giniatullin R,Tavi P,Zhang SC,Kanninen KM,Hämäläinen RH,Koistinaho J
Tue Dec 12 00:00:00 EST 2017
Canine dorsal root ganglia satellite glial cells represent an exceptional cell population with astrocytic and oligodendrocytic properties.
Scientific reports
Tongtako W,Lehmbecker A,Wang Y,Hahn K,Baumgärtner W,Gerhauser I
Tue Oct 24 00:00:00 EDT 2017
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.
Stem cell reports
Muratore CR,Zhou C,Liao M,Fernandez MA,Taylor WM,Lagomarsino VN,Pearse RV,Rice HC,Negri JM,He A,Srikanth P,Callahan DG,Shin T,Zhou M,Bennett DA,Noggle S,Love JC,Selkoe DJ,Young-Pearse TL
Tue Dec 12 00:00:00 EST 2017
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.
Nature communications
Guo W,Naujock M,Fumagalli L,Vandoorne T,Baatsen P,Boon R,Ordovás L,Patel A,Welters M,Vanwelden T,Geens N,Tricot T,Benoy V,Steyaert J,Lefebvre-Omar C,Boesmans W,Jarpe M,Sterneckert J,Wegner F,Petri S,Bohl D,Vanden Berghe P,Robberecht W,Van Damme P,Verfaillie C,Van Den Bosch L
Wed Oct 11 00:00:00 EDT 2017
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Stem cell reports
Tripathi P,Rodriguez-Muela N,Klim JR,de Boer AS,Agrawal S,Sandoe J,Lopes CS,Ogliari KS,Williams LA,Shear M,Rubin LL,Eggan K,Zhou Q
Tue Aug 08 00:00:00 EDT 2017
GC/MS-based Analysis of Volatile Metabolic Profile Along in vitro Differentiation of Human Induced Pluripotent Stem Cells.
Bio-protocol
Capuano R,Talarico RV,Spitalieri P,Paolesse R,Novelli G,Sangiuolo F,Di Natale C
450-13 was used in Cell Culture to provide a protocol for volatile organic compounds (VOCs) analysis from human induced pluripotent stem cells (hiPSCs).
Tue Dec 05 00:00:00 EST 2017
Differentiation of Oligodendrocyte Precursor Cells from Sox10-Venus Mice to Oligodendrocytes and Astrocytes.
Scientific reports
Suzuki N,Sekimoto K,Hayashi C,Mabuchi Y,Nakamura T,Akazawa C
Thu Oct 26 00:00:00 EDT 2017
TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells.
Scientific reports
Wang L,Li X,Huang W,Zhou T,Wang H,Lin A,Hutchins AP,Su Z,Chen Q,Pei D,Pan G
Thu Mar 03 00:00:00 EST 2016
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Nature communications
Kapeli K,Pratt GA,Vu AQ,Hutt KR,Martinez FJ,Sundararaman B,Batra R,Freese P,Lambert NJ,Huelga SC,Chun SJ,Liang TY,Chang J,Donohue JP,Shiue L,Zhang J,Zhu H,Cambi F,Kasarskis E,Hoon S,Ares M,Burge CB,Ravits J,Rigo F,Yeo GW
Tue Jul 05 00:00:00 EDT 2016
Predegenerated Schwann cells--a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity.
Scientific reports
Smedowski A,Liu X,Pietrucha-Dutczak M,Matuszek I,Varjosalo M,Lewin-Kowalik J
Fri Apr 01 00:00:00 EDT 2016
Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan.
PloS one
Albrecht S,Hagemeier K,Ehrlich M,Kemming C,Trotter J,Kuhlmann T
450-13 was used in In vitro experiments to influence the expression of genes, such as prostaglandin D2 synthase which has neuromodulatory properties.
Fri Nov 17 00:00:00 EST 2017
Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line.
Scientific reports
Sluch VM,Davis CH,Ranganathan V,Kerr JM,Krick K,Martin R,Berlinicke CA,Marsh-Armstrong N,Diamond JS,Mao HQ,Zack DJ
Fri Nov 13 00:00:00 EST 2015
Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.
Nature communications
Adams KL,Rousso DL,Umbach JA,Novitch BG
Tue Apr 14 00:00:00 EDT 2015
Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.
Nature communications
Adams KL,Rousso DL,Umbach JA,Novitch BG
Tue Apr 14 00:00:00 EDT 2015
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Scientific reports
Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP
Mon Nov 09 00:00:00 EST 2015
(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation.
EMBO reports
Fiesel FC,Ando M,Hudec R,Hill AR,Castanedes-Casey M,Caulfield TR,Moussaud-Lamodière EL,Stankowski JN,Bauer PO,Lorenzo-Betancor O,Ferrer I,Arbelo JM,Siuda J,Chen L,Dawson VL,Dawson TM,Wszolek ZK,Ross OA,Dickson DW,Springer W
450-13 was used in Cell Culture to suggest that pS65-Ub accumulates with stress, disease, or age, and highlight its significance and potential for future biomarker and/or therapeutic development.
Tue Sep 01 00:00:00 EDT 2015
Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.
Proceedings of the National Academy of Sciences of the United States of America
Wang Y,Chakravarty P,Ranes M,Kelly G,Brooks PJ,Neilan E,Stewart A,Schiavo G,Svejstrup JQ
Tue Oct 07 00:00:00 EDT 2014
Generation of neuronal progenitor cells in response to tumors in the human brain.
Stem cells (Dayton, Ohio)
Macas J,Ku MC,Nern C,Xu Y,Bühler H,Remke M,Synowitz M,Franz K,Seifert V,Plate KH,Kettenmann H,Glass R,Momma S
Wed Jan 01 00:00:00 EST 2014
Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.
The Journal of biological chemistry
Rizvi S,Mertens JC,Bronk SF,Hirsova P,Dai H,Roberts LR,Kaufmann SH,Gores GJ
Fri Aug 15 00:00:00 EDT 2014
Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis.
The Journal of biological chemistry
Lu L,Zheng L,Si Y,Luo W,Dujardin G,Kwan T,Potochick NR,Thompson SR,Schneider DA,King PH
Fri Nov 14 00:00:00 EST 2014
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
Cell
Xue Y,Ouyang K,Huang J,Zhou Y,Ouyang H,Li H,Wang G,Wu Q,Wei C,Bi Y,Jiang L,Cai Z,Sun H,Zhang K,Zhang Y,Chen J,Fu XD
Thu Jan 17 00:00:00 EST 2013
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
Cell
Xue Y,Ouyang K,Huang J,Zhou Y,Ouyang H,Li H,Wang G,Wu Q,Wei C,Bi Y,Jiang L,Cai Z,Sun H,Zhang K,Zhang Y,Chen J,Fu XD
Thu Jan 17 00:00:00 EST 2013
Zac1 regulates astroglial differentiation of neural stem cells through Socs3.
Stem cells (Dayton, Ohio)
Schmidt-Edelkraut U,Hoffmann A,Daniel G,Spengler D
Thu Aug 01 00:00:00 EDT 2013
Zac1 regulates astroglial differentiation of neural stem cells through Socs3.
Stem cells (Dayton, Ohio)
Schmidt-Edelkraut U,Hoffmann A,Daniel G,Spengler D
Thu Aug 01 00:00:00 EDT 2013
Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
Stem cells (Dayton, Ohio)
Przybyla LM,Theunissen TW,Jaenisch R,Voldman J
Sat Jun 01 00:00:00 EDT 2013
Pigment epithelium-derived factor released by Müller glial cells exerts neuroprotective effects on retinal ganglion cells.
Neurochemical research
Unterlauft JD,Eichler W,Kuhne K,Yang XM,Yafai Y,Wiedemann P,Reichenbach A,Claudepierre T
Sun Jul 01 00:00:00 EDT 2012
A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
The Journal of biological chemistry
Hayashi H,Eguchi Y,Fukuchi-Nakaishi Y,Takeya M,Nakagata N,Tanaka K,Vance JE,Tanihara H
Fri Jul 20 00:00:00 EDT 2012
Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury.
PloS one
Davies SJ,Shih CH,Noble M,Mayer-Proschel M,Davies JE,Proschel C
Wed Mar 02 00:00:00 EST 2011
Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity.
Proceedings of the National Academy of Sciences of the United States of America
Barkis WB,Ford KJ,Feller MB
Tue Dec 21 00:00:00 EST 2010
High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function.
Molecular neurodegeneration
Fallini C,Bassell GJ,Rossoll W
Wed Apr 21 00:00:00 EDT 2010
Immunopanning purification and long-term culture of human retinal ganglion cells.
Molecular vision
Zhang XM,Li Liu DT,Chiang SW,Choy KW,Pang CP,Lam DS,Yam GH
Tue Dec 28 00:00:00 EST 2010
Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury.
Journal of biology
Davies JE,Pröschel C,Zhang N,Noble M,Mayer-Pröschel M,Davies SJ
Fri Sep 19 00:00:00 EDT 2008
Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation.
Biomaterials
Nakajima M,Ishimuro T,Kato K,Ko IK,Hirata I,Arima Y,Iwata H
Thu Feb 01 00:00:00 EST 2007
Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine.
Annals of the New York Academy of Sciences
Cass WA,Peters LE,Harned ME,Seroogy KB
Tue Aug 01 00:00:00 EDT 2006
Cytokine suppression of dopamine-beta-hydroxylase by extracellular signal-regulated kinase-dependent and -independent pathways.
The Journal of biological chemistry
Dziennis S,Habecker BA
Fri May 02 00:00:00 EDT 2003
Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression.
European journal of biochemistry
Mellott T,Lopez-Coviella I,Blusztajn JK,Berse B
Fri Feb 01 00:00:00 EST 2002
Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vicario-Abejón C,Collin C,McKay RD,Segal M
Tue Sep 15 00:00:00 EDT 1998
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hanson MG,Shen S,Wiemelt AP,McMorris FA,Barres BA
Tue Sep 15 00:00:00 EDT 1998
Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures.
The Journal of physiology
Liou JC,Yang RS,Fu WM
Fri Aug 15 00:00:00 EDT 1997
