Product References
C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.
iScience
Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y
300-28A was used in In vitro experiments to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.
Fri Oct 20 00:00:00 EDT 2023
Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses.
Nature methods
Albanese M,Ruhle A,Mittermaier J,Mejías-Pérez E,Gapp M,Linder A,Schmacke NA,Hofmann K,Hennrich AA,Levy DN,Humpe A,Conzelmann KK,Hornung V,Fackler OT,Keppler OT
Sat Jan 01 00:00:00 EST 2022
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
The Journal of experimental medicine
He Y,Gallman AE,Xie C,Shen Q,Ma J,Wolfreys FD,Sandy M,Arsov T,Wu X,Qin Y,Zhang P,Jiang S,Stanley M,Wu P,Tan J,Ding H,Xue H,Chen W,Xu J,Criswell LA,Nititham J,Adamski M,Kitching AR,Cook MC,Cao L,Shen N,Cyster JG,Vinuesa CG
300-28A was used in Sample Preparation (FC/FACS) to identify germline novel or rare P2RY8 missense variants in lupus kindreds or the related antiphospholipid syndrome, including a de novo" variant in a child with severe nephritis to uncover a role of P2RY8 in immunological tolerance and lupus pathogenesis."
Mon Jan 03 00:00:00 EST 2022
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
The Journal of experimental medicine
He Y,Gallman AE,Xie C,Shen Q,Ma J,Wolfreys FD,Sandy M,Arsov T,Wu X,Qin Y,Zhang P,Jiang S,Stanley M,Wu P,Tan J,Ding H,Xue H,Chen W,Xu J,Criswell LA,Nititham J,Adamski M,Kitching AR,Cook MC,Cao L,Shen N,Cyster JG,Vinuesa CG
300-28A was used in Sample Preparation (FC/FACS) to identify germline novel or rare P2RY8 missense variants in lupus kindreds or the related antiphospholipid syndrome, including a de novo" variant in a child with severe nephritis to uncover a role of P2RY8 in immunological tolerance and lupus pathogenesis."
Mon Jan 03 00:00:00 EST 2022
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
The Journal of experimental medicine
He Y,Gallman AE,Xie C,Shen Q,Ma J,Wolfreys FD,Sandy M,Arsov T,Wu X,Qin Y,Zhang P,Jiang S,Stanley M,Wu P,Tan J,Ding H,Xue H,Chen W,Xu J,Criswell LA,Nititham J,Adamski M,Kitching AR,Cook MC,Cao L,Shen N,Cyster JG,Vinuesa CG
300-28A was used in Sample Preparation (FC/FACS) to identify germline novel or rare P2RY8 missense variants in lupus kindreds or the related antiphospholipid syndrome, including a de novo" variant in a child with severe nephritis to uncover a role of P2RY8 in immunological tolerance and lupus pathogenesis."
Mon Jan 03 00:00:00 EST 2022
KLF8 promotes invasive outgrowth of breast cancer by inducing filopodium-like protrusions via CXCR4.
American journal of translational research
Mukherjee D,Hao J,Lu H,Lahiri SK,Yu L,Zhao J
300-28A was used in In vitro experiments to shed new light on the role of KLF8 in promoting breast cancer recurrence, the fatal episode of the disease, by inducing CXCR4-dependent FLP formation.
Mon Mar 14 00:00:00 EDT 2022
Gβγ mediates activation of Rho guanine nucleotide exchange factor ARHGEF17 that promotes metastatic lung cancer progression.
The Journal of biological chemistry
García-Jiménez I,Cervantes-Villagrana RD,Del-Río-Robles JE,Castillo-Kauil A,Beltrán-Navarro YM,García-Román J,Reyes-Cruz G,Vázquez-Prado J
Sat Jan 01 00:00:00 EST 2022
Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment.
JCI insight
Felker S,Shrestha A,Bailey J,Pillis DM,Siniard D,Malik P
300-28A was used in Cell Culture to show a mechanism for why i.b.m. transplants do not significantly improve long-term engraftment over i.v. transplants.
Mon May 09 00:00:00 EDT 2022
FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia.
Blood
Seda V,Vojackova E,Ondrisova L,Kostalova L,Sharma S,Loja T,Mladonicka Pavlasova G,Zicha D,Kudlickova Peskova M,Krivanek J,Liskova K,Kren L,Benes V,Musilova Litzmanova K,Borsky M,Oppelt J,Verner J,Pospisilova S,Brychtova Y,Panovska A,Tan Z,Zhang S,Doubek M,Amruz Cerna K,Mayer J,Mraz M
Thu Sep 02 00:00:00 EDT 2021
An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation.
Acta pharmaceutica Sinica. B
Harms M,Habib MMW,Nemska S,Nicolò A,Gilg A,Preising N,Sokkar P,Carmignani S,Raasholm M,Weidinger G,Kizilsavas G,Wagner M,Ständker L,Abadi AH,Jumaa H,Kirchhoff F,Frossard N,Sanchez-Garcia E,Münch J
300-28A was used in In vitro experiments to investigate the effectiveness of EPI-X4 in treating CXCR4-associated diseases.
Wed Sep 01 00:00:00 EDT 2021
Extracellular vesicles from human iPSCs enhance reconstitution capacity of cord blood-derived hematopoietic stem and progenitor cells.
Leukemia
Karnas E,Sekuła-Stryjewska M,Kmiotek-Wasylewska K,Bobis-Wozowicz S,Ryszawy D,Sarna M,Madeja Z,Zuba-Surma EK
Fri Oct 01 00:00:00 EDT 2021
Enhancement of myogenic differentiation and inhibition of rhabdomyosarcoma progression by miR-28-3p and miR-193a-5p regulated by SNAIL.
Molecular therapy. Nucleic acids
Skrzypek K,Nieszporek A,Badyra B,Lasota M,Majka M
Fri Jun 04 00:00:00 EDT 2021
Stromal cell-derived factor-1/Exendin-4 cotherapy facilitates the proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells in vitro and promotes periodontal bone regeneration in vivo.
Cell proliferation
Liang Q,Du L,Zhang R,Kang W,Ge S
Mon Mar 01 00:00:00 EST 2021
Stromal cell-derived factor-1/Exendin-4 cotherapy facilitates the proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells in vitro and promotes periodontal bone regeneration in vivo.
Cell proliferation
Liang Q,Du L,Zhang R,Kang W,Ge S
Mon Mar 01 00:00:00 EST 2021
Stromal cell-derived factor-1/Exendin-4 cotherapy facilitates the proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells in vitro and promotes periodontal bone regeneration in vivo.
Cell proliferation
Liang Q,Du L,Zhang R,Kang W,Ge S
Mon Mar 01 00:00:00 EST 2021
Xinkeshu Improves Endothelial Function and Augments Reendothelialization Capacity in Coronary Artery Disease with Anxiety/Depression.
Oxidative medicine and cellular longevity
Sun J,Zhou M,Lv G,Li W,Liu Y,Liang J,Zhang J,Zhang S,Deng Y,Tao J
Fri Jan 28 00:00:00 EST 2022
Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells.
Cell adhesion & migration
Roncato F,Regev O,Yadav SK,Alon R
300-28A was used in In vitro experiments to investigate microtubule turnover in epithelial barriers.
Wed Dec 01 00:00:00 EST 2021
Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.
The Journal of biological chemistry
Khater M,Bryant CN,Wu G
Tue Aug 31 00:00:00 EDT 2021
Endothelial STING controls T cell transmigration in an IFNI-dependent manner.
JCI insight
Anastasiou M,Newton GA,Kaur K,Carrillo-Salinas FJ,Smolgovsky SA,Bayer AL,Ilyukha V,Sharma S,Poltorak A,Luscinskas FW,Alcaide P
300-28A was used in In vitro experiments to investigate IFN signalling effect on T cell transdoepithelial infiltration.
Mon Aug 09 00:00:00 EDT 2021
G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Nature communications
Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N
Tue Nov 23 00:00:00 EST 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 EDT 2021
G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers.
The Journal of biological chemistry
Khater M,Wei Z,Xu X,Huang W,Lokeshwar BL,Lambert NA,Wu G
Thu Aug 26 00:00:00 EDT 2021
G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers.
The Journal of biological chemistry
Khater M,Wei Z,Xu X,Huang W,Lokeshwar BL,Lambert NA,Wu G
Thu Aug 26 00:00:00 EDT 2021
CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice.
Scientific reports
Koo HS,Yoon MJ,Hong SH,Ahn J,Cha H,Lee D,Ko JE,Kwon H,Choi DH,Lee KA,Ko JJ,Kang YJ
Thu Apr 01 00:00:00 EDT 2021
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control.
Nature biomedical engineering
Miller IC,Zamat A,Sun LK,Phuengkham H,Harris AM,Gamboa L,Yang J,Murad JP,Priceman SJ,Kwong GA
Mon Nov 01 00:00:00 EDT 2021
Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies.
Nature communications
Biber G,Ben-Shmuel A,Noy E,Joseph N,Puthenveetil A,Reiss N,Levy O,Lazar I,Feiglin A,Ofran Y,Kedmi M,Avigdor A,Fried S,Barda-Saad M
Wed Sep 22 00:00:00 EDT 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
Wed Jul 21 00:00:00 EDT 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
Wed Jul 21 00:00:00 EDT 2021
Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists.
Communications biology
Sokkar P,Harms M,Stürzel C,Gilg A,Kizilsavas G,Raasholm M,Preising N,Wagner M,Kirchhoff F,Ständker L,Weidinger G,Mayer B,Münch J,Sanchez-Garcia E
Wed Sep 22 00:00:00 EDT 2021
Chemokine Therapy in Cats With Experimental Renal Fibrosis and in a Kidney Disease Pilot Study.
Frontiers in veterinary science
Bennington J,Lankford S,Magalhaes RS,Shankle D,Fanning J,Kartini C,Suparto I,Kusumawardhani W,Putra MA,Mariya S,Badlani G,Williams JK
300-28A was used in In vivo experiments to test the effects of intra-renal chemokine CXCL12 injection in the pre-clinical cat model of unilateral ischemia/reperfusion (I/R)-induced kidney fibrosis and then, within a clinical pilot study, test the safety/feasibility of CXCL12 injection in cats that might have early chronic kidney disease (CKD) to suggest that intra-renal injection of CXCL12 may prove to be an effective treatment for kidney fibrosis in cats with CKD.
Tue Mar 23 00:00:00 EDT 2021
A Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease.
International journal of molecular sciences
de Haan L,Suijker J,van Roey R,Berges N,Petrova E,Queiroz K,Strijker W,Olivier T,Poeschke O,Garg S,van den Broek LJ
300-28A was used in Cell Culture to showcase a comprehensive, 3D microfluidic endothelial assay to study transendothelial migration of T cell, with potential application in immunopathology research and immunotherapeutic development.
Fri Jul 30 00:00:00 EDT 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
Tue Jun 08 00:00:00 EDT 2021
Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury.
The Journal of clinical investigation
Masoud AG,Lin J,Azad AK,Farhan MA,Fischer C,Zhu LF,Zhang H,Sis B,Kassiri Z,Moore RB,Kim D,Anderson CC,Vederas JC,Adam BA,Oudit GY,Murray AG
Thu Jan 02 00:00:00 EST 2020
Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties.
Advanced healthcare materials
Chang CW,Seibel AJ,Avendano A,Cortes-Medina MG,Song JW
Sat Feb 01 00:00:00 EST 2020
Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid.
Frontiers in molecular neuroscience
Spampinato SF,Merlo S,Fagone E,Fruciano M,Sano Y,Kanda T,Sortino MA
300-28A was used in In vivo experiments to show reciprocal crosstalk between infiltrating peripheral cells and astrocytes upon Aβ exposure.
Mon Sep 28 00:00:00 EDT 2020
Metformin suppresses HIF-1α expression in cancer-associated fibroblasts to prevent tumor-stromal cross talk in breast cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shao S,Zhao L,An G,Zhang L,Jing X,Luo M,Li W,Meng D,Ning Q,Zhao X,Lei J
Sat Aug 01 00:00:00 EDT 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
Sat Aug 01 00:00:00 EDT 2020
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides.
Nature communications
Meyrath M,Szpakowska M,Zeiner J,Massotte L,Merz MP,Benkel T,Simon K,Ohnmacht J,Turner JD,Krüger R,Seutin V,Ollert M,Kostenis E,Chevigné A
Fri Jun 19 00:00:00 EDT 2020
Cxcr4 and Sdf-1 are critically involved in the formation of facial and non-somitic neck muscles.
Scientific reports
Yahya I,Böing M,Pu Q,Puchert M,Oedemis V,Engele J,Brand-Saberi B,Morosan-Puopolo G
Thu Mar 19 00:00:00 EDT 2020
Cytotoxic T cells swarm by homotypic chemokine signalling.
eLife
Galeano Niño JL,Pageon SV,Tay SS,Colakoglu F,Kempe D,Hywood J,Mazalo JK,Cremasco J,Govendir MA,Dagley LF,Hsu K,Rizzetto S,Zieba J,Rice G,Prior V,O'Neill GM,Williams RJ,Nisbet DR,Kramer B,Webb AI,Luciani F,Read MN,Biro M
Tue Oct 13 00:00:00 EDT 2020
Bimodal Imaging-Visible Nanomedicine Integrating CXCR4 and VEGFa Genes Directs Synergistic Reendothelialization of Endothelial Progenitor Cells.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Yu B,Dong B,He J,Huang H,Huang J,Wang Y,Liang J,Zhang J,Qiu Y,Shen J,Shuai X,Tao J,Xia W
Tue Dec 01 00:00:00 EST 2020
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes.
Cell chemical biology
White CW,Caspar B,Vanyai HK,Pfleger KDG,Hill SJ
300-28A was used in In vitro experiments to show that genetically encoded luminescent biosensors can be used to investigate numerous aspects of receptor function at native expression levels.
Thu May 21 00:00:00 EDT 2020
Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies.
Cell chemical biology
Soave M,Heukers R,Kellam B,Woolard J,Smit MJ,Briddon SJ,Hill SJ
300-28A was used in Binding assay to investigate nanobody treatment.
Thu Oct 15 00:00:00 EDT 2020
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting.
Nature communications
Kontos C,El Bounkari O,Krammer C,Sinitski D,Hille K,Zan C,Yan G,Wang S,Gao Y,Brandhofer M,Megens RTA,Hoffmann A,Pauli J,Asare Y,Gerra S,Bourilhon P,Leng L,Eckstein HH,Kempf WE,Pelisek J,Gokce O,Maegdefessel L,Bucala R,Dichgans M,Weber C,Kapurniotu A,Bernhagen J
Wed Nov 25 00:00:00 EST 2020
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting.
Nature communications
Kontos C,El Bounkari O,Krammer C,Sinitski D,Hille K,Zan C,Yan G,Wang S,Gao Y,Brandhofer M,Megens RTA,Hoffmann A,Pauli J,Asare Y,Gerra S,Bourilhon P,Leng L,Eckstein HH,Kempf WE,Pelisek J,Gokce O,Maegdefessel L,Bucala R,Dichgans M,Weber C,Kapurniotu A,Bernhagen J
Wed Nov 25 00:00:00 EST 2020
Anti-CD81 antibodies reduce migration of activated T lymphocytes and attenuate mouse experimental colitis.
Scientific reports
Hasezaki T,Yoshima T,Mine Y
Fri Apr 24 00:00:00 EDT 2020
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity.
The Journal of clinical investigation
Crippa S,Rossella V,Aprile A,Silvestri L,Rivis S,Scaramuzza S,Pirroni S,Avanzini MA,Basso-Ricci L,Hernandez RJ,Zecca M,Marktel S,Ciceri F,Aiuti A,Ferrari G,Bernardo ME
Mon Feb 25 00:00:00 EST 2019
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function.
The Journal of experimental medicine
Lam MT,Coppola S,Krumbach OHF,Prencipe G,Insalaco A,Cifaldi C,Brigida I,Zara E,Scala S,Di Cesare S,Martinelli S,Di Rocco M,Pascarella A,Niceta M,Pantaleoni F,Ciolfi A,Netter P,Carisey AF,Diehl M,Akbarzadeh M,Conti F,Merli P,Pastore A,Levi Mortera S,Camerini S,Farina L,Buchholzer M,Pannone L,Cao TN,Coban-Akdemir ZH,Jhangiani SN,Muzny DM,Gibbs RA,Basso-Ricci L,Chiriaco M,Dvorsky R,Putignani L,Carsetti R,Janning P,Stray-Pedersen A,Erichsen HC,Horne A,Bryceson YT,Torralba-Raga L,Ramme K,Rosti V,Bracaglia C,Messia V,Palma P,Finocchi A,Locatelli F,Chinn IK,Lupski JR,Mace EM,Cancrini C,Aiuti A,Ahmadian MR,Orange JS,De Benedetti F,Tartaglia M
300-28A was used in In vitro experiments to investigate the association of CDC42 mutations with syndromic neurodevelopmental disorders.
Mon Dec 02 00:00:00 EST 2019
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function.
The Journal of experimental medicine
Lam MT,Coppola S,Krumbach OHF,Prencipe G,Insalaco A,Cifaldi C,Brigida I,Zara E,Scala S,Di Cesare S,Martinelli S,Di Rocco M,Pascarella A,Niceta M,Pantaleoni F,Ciolfi A,Netter P,Carisey AF,Diehl M,Akbarzadeh M,Conti F,Merli P,Pastore A,Levi Mortera S,Camerini S,Farina L,Buchholzer M,Pannone L,Cao TN,Coban-Akdemir ZH,Jhangiani SN,Muzny DM,Gibbs RA,Basso-Ricci L,Chiriaco M,Dvorsky R,Putignani L,Carsetti R,Janning P,Stray-Pedersen A,Erichsen HC,Horne A,Bryceson YT,Torralba-Raga L,Ramme K,Rosti V,Bracaglia C,Messia V,Palma P,Finocchi A,Locatelli F,Chinn IK,Lupski JR,Mace EM,Cancrini C,Aiuti A,Ahmadian MR,Orange JS,De Benedetti F,Tartaglia M
300-28A was used in In vitro experiments to investigate the association of CDC42 mutations with syndromic neurodevelopmental disorders.
Mon Dec 02 00:00:00 EST 2019
High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse.
Leukemia
Velázquez-Avila M,Balandrán JC,Ramírez-Ramírez D,Velázquez-Avila M,Sandoval A,Felipe-López A,Nava P,Alvarado-Moreno JA,Dozal D,Prieto-Chávez JL,Schaks M,Rottner K,Dorantes-Acosta E,López-Martínez B,Schnoor M,Pelayo R
Sat Jun 01 00:00:00 EDT 2019
Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.
Oncogene
Willems E,Dedobbeleer M,Digregorio M,Lombard A,Goffart N,Lumapat PN,Lambert J,Van den Ackerveken P,Szpakowska M,Chevigné A,Scholtes F,Rogister B
Tue Jan 01 00:00:00 EST 2019
Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.
Oncogene
Willems E,Dedobbeleer M,Digregorio M,Lombard A,Goffart N,Lumapat PN,Lambert J,Van den Ackerveken P,Szpakowska M,Chevigné A,Scholtes F,Rogister B
Tue Jan 01 00:00:00 EST 2019
Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties.
Stem cells (Dayton, Ohio)
Abu-Khader A,Law KW,Jahan S,Manesia JK,Pasha R,Hovey O,Pineault N
Fri Mar 01 00:00:00 EST 2019
Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.
Journal of immunology (Baltimore, Md. : 1950)
Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM
Fri Feb 15 00:00:00 EST 2019
Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Bagherzadeh Yazdchi S,Witalis M,Meli AP,Leung J,Li X,Panneton V,Chang J,Li J,Nutt SL,Johnson RL,Lim DS,Gu H,King IL,Suh WK
Tue Jan 01 00:00:00 EST 2019
Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1.
Nature communications
Leclerc M,Voilin E,Gros G,Corgnac S,de Montpréville V,Validire P,Bismuth G,Mami-Chouaib F
Fri Jul 26 00:00:00 EDT 2019
CXCR7 promotes melanoma tumorigenesis via Src kinase signaling.
Cell death & disease
Xu S,Tang J,Wang C,Liu J,Fu Y,Luo Y
Mon Feb 25 00:00:00 EST 2019
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
The Journal of biological chemistry
Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S
Fri Jul 19 00:00:00 EDT 2019
Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins.
The Journal of biological chemistry
Cervantes-Villagrana RD,Adame-García SR,García-Jiménez I,Color-Aparicio VM,Beltrán-Navarro YM,König GM,Kostenis E,Reyes-Cruz G,Gutkind JS,Vázquez-Prado J
Fri Jan 11 00:00:00 EST 2019
Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins.
The Journal of biological chemistry
Cervantes-Villagrana RD,Adame-García SR,García-Jiménez I,Color-Aparicio VM,Beltrán-Navarro YM,König GM,Kostenis E,Reyes-Cruz G,Gutkind JS,Vázquez-Prado J
Fri Jan 11 00:00:00 EST 2019
A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells.
eLife
Abu-Shah E,Demetriou P,Bálint Š,Mayya V,Kutuzov MA,Dushek O,Dustin ML
300-28A was used in Sample Preparation to report a tissue-like system that recapitulates the dynamics of engineered primary human immune cell and characterise unique dynamics of T-cell/DC interactions as a function of antigen affinity.
Wed Sep 25 00:00:00 EDT 2019
AMD3100 inhibits epithelial-mesenchymal transition, cell invasion, and metastasis in the liver and the lung through blocking the SDF-1α/CXCR4 signaling pathway in prostate cancer.
Journal of cellular physiology
Zhu WB,Zhao ZF,Zhou X
300-28A was used in In vitro experiments to show that AMD3100 suppresses epithelial-mesenchymal transition and migration of PC cells by inhibiting the SDF-1α/CXCR4 signaling pathway, which provides a clinical target in the treatment of PC.
Mon Jul 01 00:00:00 EDT 2019
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer.
Cancer cell
Costa A,Kieffer Y,Scholer-Dahirel A,Pelon F,Bourachot B,Cardon M,Sirven P,Magagna I,Fuhrmann L,Bernard C,Bonneau C,Kondratova M,Kuperstein I,Zinovyev A,Givel AM,Parrini MC,Soumelis V,Vincent-Salomon A,Mechta-Grigoriou F
Mon Mar 12 00:00:00 EDT 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 EST 2018
IL-33 Upregulates Cysteinyl Leukotriene Receptor Type 1 Expression in Human Peripheral Blood CD4+ T Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Boudaud M,Turcotte S,Stankova J,Rola-Pleszczynski M
Thu Nov 01 00:00:00 EDT 2018
Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning.
Journal of immunology (Baltimore, Md. : 1950)
Heredia JD,Park J,Brubaker RJ,Szymanski SK,Gill KS,Procko E
Fri Jun 01 00:00:00 EDT 2018
CXCR4/SDF1 signalling promotes sensory neuron clustering in vitro.
Biology open
Terheyden-Keighley D,Zhang X,Brand-Saberi B,Theiss C
300-28A was used in In vitro experiments to investigate mechanisms of dorsal root ganglia formation in development.
Wed Sep 19 00:00:00 EDT 2018
SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis.
Cell cycle (Georgetown, Tex.)
Kodigepalli KM,Bonifati S,Tirumuru N,Wu L
300-28A was used in Cell Culture to show that SAMHD1 KO in THP-1 cells increased PI3K activity and reduced expression of the tumor suppressor PTEN.
Tue Dec 17 00:00:00 EST 2019
Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3-mediated chemokine scavenging.
The Journal of biological chemistry
Montpas N,St-Onge G,Nama N,Rhainds D,Benredjem B,Girard M,Hickson G,Pons V,Heveker N
Fri Jan 19 00:00:00 EST 2018
Gγ identity dictates efficacy of Gβγ signaling and macrophage migration.
The Journal of biological chemistry
Senarath K,Payton JL,Kankanamge D,Siripurapu P,Tennakoon M,Karunarathne A
Fri Feb 23 00:00:00 EST 2018
Gγ identity dictates efficacy of Gβγ signaling and macrophage migration.
The Journal of biological chemistry
Senarath K,Payton JL,Kankanamge D,Siripurapu P,Tennakoon M,Karunarathne A
Fri Feb 23 00:00:00 EST 2018
Surface functionalization of electrospun scaffolds using recombinant human decorin attracts circulating endothelial progenitor cells.
Scientific reports
Hinderer S,Sudrow K,Schneider M,Holeiter M,Layland SL,Seifert M,Schenke-Layland K
Mon Jan 08 00:00:00 EST 2018
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Scientific reports
Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S
Fri Apr 20 00:00:00 EDT 2018
Convective forces increase CXCR4-dependent glioblastoma cell invasion in GL261 murine model.
Scientific reports
Cornelison RC,Brennan CE,Kingsmore KM,Munson JM
Mon Nov 19 00:00:00 EST 2018
Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration.
Frontiers in immunology
Parodi M,Raggi F,Cangelosi D,Manzini C,Balsamo M,Blengio F,Eva A,Varesio L,Pietra G,Moretta L,Mingari MC,Vitale M,Bosco MC
300-28A was used in In vitro experiments to study the mechanisms by which hypoxia acts on natural killer cells.
Wed Oct 02 00:00:00 EDT 2019
SOX11 promotes tumor protective microenvironment interactions through CXCR4 and FAK regulation in mantle cell lymphoma.
Blood
Balsas P,Palomero J,Eguileor Á,Rodríguez ML,Vegliante MC,Planas-Rigol E,Sureda-Gómez M,Cid MC,Campo E,Amador V
Thu Jul 27 00:00:00 EDT 2017
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Xu X,Han L,Zhao G,Xue S,Gao Y,Xiao J,Zhang S,Chen P,Wu ZY,Ding J,Hu R,Wei B,Wang H
Sun Jan 01 00:00:00 EST 2017
Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets.
Journal of cellular physiology
Buskermolen JK,Roffel S,Gibbs S
Wed Nov 01 00:00:00 EDT 2017
Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis.
Journal of immunology (Baltimore, Md. : 1950)
Hooshmand MJ,Nguyen HX,Piltti KM,Benavente F,Hong S,Flanagan L,Uchida N,Cummings BJ,Anderson AJ
Tue Aug 01 00:00:00 EDT 2017
A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.
Scientific reports
Zhang Y,Wu Y,Qi H,Xiao J,Gong H,Zhang Y,Xu E,Li S,Ma D,Wang Y,Li W,Shen H
Wed Nov 08 00:00:00 EST 2017
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Stem cell reports
Tripathi P,Rodriguez-Muela N,Klim JR,de Boer AS,Agrawal S,Sandoe J,Lopes CS,Ogliari KS,Williams LA,Shear M,Rubin LL,Eggan K,Zhou Q
Tue Aug 08 00:00:00 EDT 2017
Isopeptide and ester bond ubiquitination both regulate degradation of the human dopamine receptor 4.
The Journal of biological chemistry
Peeler JC,Schedin-Weiss S,Soula M,Kazmi MA,Sakmar TP
Fri Dec 29 00:00:00 EST 2017
Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.
The Journal of biological chemistry
Benredjem B,Girard M,Rhainds D,St-Onge G,Heveker N
Fri Jan 06 00:00:00 EST 2017
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Scientific reports
Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S
Tue Jun 27 00:00:00 EDT 2017
HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment.
Blood
Valsecchi R,Coltella N,Belloni D,Ponente M,Ten Hacken E,Scielzo C,Scarfò L,Bertilaccio MT,Brambilla P,Lenti E,Martinelli Boneschi F,Brendolan A,Ferrero E,Ferrarini M,Ghia P,Tonon G,Ponzoni M,Caligaris-Cappio F,Bernardi R
Thu Apr 21 00:00:00 EDT 2016
Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.
Proceedings of the National Academy of Sciences of the United States of America
Wescott MP,Kufareva I,Paes C,Goodman JR,Thaker Y,Puffer BA,Berdougo E,Rucker JB,Handel TM,Doranz BJ
Tue Aug 30 00:00:00 EDT 2016
Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model.
Disease models & mechanisms
Tulotta C,Stefanescu C,Beletkaia E,Bussmann J,Tarbashevich K,Schmidt T,Snaar-Jagalska BE
300-28A was used in Immunocytochemistry-immunoflourescence to study the limited efficacy of current treatments for triple-negative breast cancer (TNBC) by studying the role of the XCR4-CXCL12 axis in the formation of TNBC early metastases using a zebrafish xenograft model.
Mon Feb 01 00:00:00 EST 2016
Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.
Journal of immunology (Baltimore, Md. : 1950)
Michlmayr D,Bardina SV,Rodriguez CA,Pletnev AG,Lim JK
Wed Jun 01 00:00:00 EDT 2016
Glucocorticoids Suppress CCR9-Mediated Chemotaxis, Calcium Flux, and Adhesion to MAdCAM-1 in Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Wendt E,White GE,Ferry H,Huhn M,Greaves DR,Keshav S
Sun May 01 00:00:00 EDT 2016
Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.
Journal of immunology (Baltimore, Md. : 1950)
Wang X,Li T,Wang W,Yuan W,Liu H,Cheng Y,Wang P,Zhang Y,Han W
Sun May 15 00:00:00 EDT 2016
The Immune-Metabolic Basis of Effector Memory CD4+ T Cell Function under Hypoxic Conditions.
Journal of immunology (Baltimore, Md. : 1950)
Dimeloe S,Mehling M,Frick C,Loeliger J,Bantug GR,Sauder U,Fischer M,Belle R,Develioglu L,Tay S,Langenkamp A,Hess C
Fri Jan 01 00:00:00 EST 2016
Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING.
The Journal of biological chemistry
Chávez-Vargas L,Adame-García SR,Cervantes-Villagrana RD,Castillo-Kauil A,Bruystens JG,Fukuhara S,Taylor SS,Mochizuki N,Reyes-Cruz G,Vázquez-Prado J
Fri Mar 18 00:00:00 EDT 2016
Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING.
The Journal of biological chemistry
Chávez-Vargas L,Adame-García SR,Cervantes-Villagrana RD,Castillo-Kauil A,Bruystens JG,Fukuhara S,Taylor SS,Mochizuki N,Reyes-Cruz G,Vázquez-Prado J
Fri Mar 18 00:00:00 EDT 2016
Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING.
The Journal of biological chemistry
Chávez-Vargas L,Adame-García SR,Cervantes-Villagrana RD,Castillo-Kauil A,Bruystens JG,Fukuhara S,Taylor SS,Mochizuki N,Reyes-Cruz G,Vázquez-Prado J
Fri Mar 18 00:00:00 EDT 2016
Intrinsic Photosensitivity Enhances Motility of T Lymphocytes.
Scientific reports
Phan TX,Jaruga B,Pingle SC,Bandyopadhyay BC,Ahern GP
Tue Dec 20 00:00:00 EST 2016
Roles of the mitochondrial Na(+)-Ca(2+) exchanger, NCLX, in B lymphocyte chemotaxis.
Scientific reports
Kim B,Takeuchi A,Hikida M,Matsuoka S
Wed Jun 22 00:00:00 EDT 2016
i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4.
The Journal of biological chemistry
Griffiths K,Dolezal O,Cao B,Nilsson SK,See HB,Pfleger KDG,Roche M,Gorry PR,Pow A,Viduka K,Lim K,Lu BGC,Chang DHC,Murray-Rust T,Kvansakul M,Perugini MA,Dogovski C,Doerflinger M,Zhang Y,Parisi K,Casey JL,Nuttall SD,Foley M
Fri Jun 10 00:00:00 EDT 2016
Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression.
The Journal of biological chemistry
Coke CJ,Scarlett KA,Chetram MA,Jones KJ,Sandifer BJ,Davis AS,Marcus AI,Hinton CV
Fri May 06 00:00:00 EDT 2016
β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.
The Journal of biological chemistry
Alekhina O,Marchese A
Fri Dec 09 00:00:00 EST 2016
Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor.
The Journal of biological chemistry
An B,Abbonante V,Xu H,Gavriilidou D,Yoshizumi A,Bihan D,Farndale RW,Kaplan DL,Balduini A,Leitinger B,Brodsky B
Fri Feb 26 00:00:00 EST 2016
KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages.
Cell death & disease
Grimaldi A,D'Alessandro G,Golia MT,Grössinger EM,Di Angelantonio S,Ragozzino D,Santoro A,Esposito V,Wulff H,Catalano M,Limatola C
Thu Apr 07 00:00:00 EDT 2016
The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5.
Scientific reports
Lessel D,Muhammad T,Casar Tena T,Moepps B,Burkhalter MD,Hitz MP,Toka O,Rentzsch A,Schubert S,Schalinski A,Bauer UM,Kubisch C,Ware SM,Philipp M
Tue Sep 13 00:00:00 EDT 2016
The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Zsiros E,Duttagupta P,Dangaj D,Li H,Frank R,Garrabrant T,Hagemann IS,Levine BL,June CH,Zhang L,Wang E,Marincola FM,Bedognetti D,Powell DJ,Tanyi J,Feldman MD,Kandalaft LE,Coukos G
300-28A was used in Sample Preparation (FC/FACS) to show that DC-primed tumor-specific T cells are armed with the appropriate receptors to migrate toward universal ovarian cancer chemokines, and these receptors are further upregulated by ex vivo CD3/CD28 costimulation, which render T cells more fit for migrating toward these chemokines.
Mon Jun 15 00:00:00 EDT 2015
Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation.
Frontiers in oncology
Gorchs L,Hellevik T,Bruun JA,Camilio KA,Al-Saad S,Stuge TB,Martinez-Zubiaurre I
300-28A was used in In vitro experiments to conclude that CAFs play a powerful immunosuppressive effect over activated T-cells, and this effect remains unchanged after HD-RT. Importantly, CAFs do not switch on immunogenic cell death responses after exposure to HD-RT.
Mon Jun 01 00:00:00 EDT 2015
Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ramos-Amaya A,Rodríguez-Bayona B,López-Blanco R,Andújar E,Pérez-Alegre M,Campos-Caro A,Brieva JA
Sun Feb 01 00:00:00 EST 2015
Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
Journal of immunology (Baltimore, Md. : 1950)
Lourenco S,Teixeira VH,Kalber T,Jose RJ,Floto RA,Janes SM
Wed Apr 01 00:00:00 EDT 2015
The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells.
Journal of immunology (Baltimore, Md. : 1950)
Mukovozov I,Huang YW,Zhang Q,Liu GY,Siu A,Sokolskyy Y,Patel S,Hyduk SJ,Kutryk MJ,Cybulsky MI,Robinson LA
Thu Oct 01 00:00:00 EDT 2015
The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells.
Journal of immunology (Baltimore, Md. : 1950)
Mukovozov I,Huang YW,Zhang Q,Liu GY,Siu A,Sokolskyy Y,Patel S,Hyduk SJ,Kutryk MJ,Cybulsky MI,Robinson LA
Thu Oct 01 00:00:00 EDT 2015
A novel biphenyl urea derivate inhibits the invasion of breast cancer through the modulation of CXCR4.
Journal of cellular and molecular medicine
Zhan Y,Zhang H,Li J,Zhang Y,Zhang J,He L
Wed Jul 01 00:00:00 EDT 2015
BDNF Pretreatment of Human Embryonic-Derived Neural Stem Cells Improves Cell Survival and Functional Recovery After Transplantation in Hypoxic-Ischemic Stroke.
Cell transplantation
Rosenblum S,Smith TN,Wang N,Chua JY,Westbroek E,Wang K,Guzman R
300-28A was used in In vitro experiments to evaluate if pretreatment of NSCs with brain-derived neurotrophic factor (BDNF) prior to transplantation improves cell engraftment and functional recovery following hypoxic-ischemic (HI) stroke.
Wed Oct 19 00:00:00 EDT 2016
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.
Scientific reports
Jain N,Thanabalu T
Wed Oct 14 00:00:00 EDT 2015
The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.
The Journal of biological chemistry
Verma R,Marchese A
Fri Mar 13 00:00:00 EDT 2015
A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis.
Nature communications
Yuzugullu H,Baitsch L,Von T,Steiner A,Tong H,Ni J,Clayton LK,Bronson R,Roberts TM,Gritsman K,Zhao JJ
Wed Oct 07 00:00:00 EDT 2015
A protein-tagging system for signal amplification in gene expression and fluorescence imaging.
Cell
Tanenbaum ME,Gilbert LA,Qi LS,Weissman JS,Vale RD
Thu Oct 23 00:00:00 EDT 2014
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
Immunity
Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR
Thu Sep 18 00:00:00 EDT 2014
DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.
The Journal of experimental medicine
Zhang Q,Dove CG,Hor JL,Murdock HM,Strauss-Albee DM,Garcia JA,Mandl JN,Grodick RA,Jing H,Chandler-Brown DB,Lenardo TE,Crawford G,Matthews HF,Freeman AF,Cornall RJ,Germain RN,Mueller SN,Su HC
Mon Dec 15 00:00:00 EST 2014
CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface.
Proceedings of the National Academy of Sciences of the United States of America
Martínez-Muñoz L,Barroso R,Dyrhaug SY,Navarro G,Lucas P,Soriano SF,Vega B,Costas C,Muñoz-Fernández MÁ,Santiago C,Rodríguez Frade JM,Franco R,Mellado M
Tue May 13 00:00:00 EDT 2014
Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node.
Journal of immunology (Baltimore, Md. : 1950)
Yin X,Johns SC,Kim D,Mikulski Z,Salanga CL,Handel TM,Macal M,Zúñiga EI,Fuster MM
Sat Mar 01 00:00:00 EST 2014
The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406.
Journal of immunology (Baltimore, Md. : 1950)
Borge M,Remes Lenicov F,Nannini PR,de los Ríos Alicandú MM,Podaza E,Ceballos A,Fernández Grecco H,Cabrejo M,Bezares RF,Morande PE,Oppezzo P,Giordano M,Gamberale R
Mon Sep 15 00:00:00 EDT 2014
The two human CXCR4 isoforms display different HIV receptor activities: consequences for the emergence of X4 strains.
Journal of immunology (Baltimore, Md. : 1950)
Duquenne C,Psomas C,Gimenez S,Guigues A,Carles MJ,Barbuat C,Lavigne JP,Sotto A,Reynes J,Guglielmi P,Mettling C,François V,Corbeau P
Wed Oct 15 00:00:00 EDT 2014
PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2.
Journal of immunology (Baltimore, Md. : 1950)
Pei X,Sun Q,Zhang Y,Wang P,Peng X,Guo C,Xu E,Zheng Y,Mo X,Ma J,Chen D,Zhang Y,Zhang Y,Song Q,Guo S,Shi T,Zhang Z,Ma D,Wang Y
Sat Feb 15 00:00:00 EST 2014
Chemokine cooperativity is caused by competitive glycosaminoglycan binding.
Journal of immunology (Baltimore, Md. : 1950)
Verkaar F,van Offenbeek J,van der Lee MMC,van Lith LHCJ,Watts AO,Rops ALWMM,Aguilar DC,Ziarek JJ,van der Vlag J,Handel TM,Volkman BF,Proudfoot AEI,Vischer HF,Zaman GJR,Smit MJ
Tue Apr 15 00:00:00 EDT 2014
Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models.
Scientific reports
Chwalek K,Tsurkan MV,Freudenberg U,Werner C
Wed Mar 19 00:00:00 EDT 2014
Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration.
The Journal of biological chemistry
Ong ST,Freeley M,Skubis-Zegadło J,Fazil MH,Kelleher D,Fresser F,Baier G,Verma NK,Long A
Fri Jul 11 00:00:00 EDT 2014
The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.
Immunity
Henao-Mejia J,Williams A,Goff LA,Staron M,Licona-Limón P,Kaech SM,Nakayama M,Rinn JL,Flavell RA
Thu May 23 00:00:00 EDT 2013
Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia.
Blood
ten Hacken E,Scielzo C,Bertilaccio MT,Scarfò L,Apollonio B,Barbaglio F,Stamatopoulos K,Ponzoni M,Ghia P,Caligaris-Cappio F
Thu Mar 21 00:00:00 EDT 2013
Antibacterial effect of microvesicles released from human neutrophilic granulocytes.
Blood
Timár CI,Lorincz AM,Csépányi-Kömi R,Vályi-Nagy A,Nagy G,Buzás EI,Iványi Z,Kittel A,Powell DW,McLeish KR,Ligeti E
Thu Jan 17 00:00:00 EST 2013
Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide.
Blood
Ramsay AG,Evans R,Kiaii S,Svensson L,Hogg N,Gribben JG
Thu Apr 04 00:00:00 EDT 2013
B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells.
The Journal of clinical investigation
Mahévas M,Patin P,Huetz F,Descatoire M,Cagnard N,Bole-Feysot C,Le Gallou S,Khellaf M,Fain O,Boutboul D,Galicier L,Ebbo M,Lambotte O,Hamidou M,Bierling P,Godeau B,Michel M,Weill JC,Reynaud CA
Tue Jan 01 00:00:00 EST 2013
Opposing chemokine gradients control human thymocyte migration in situ.
The Journal of clinical investigation
Halkias J,Melichar HJ,Taylor KT,Ross JO,Yen B,Cooper SB,Winoto A,Robey EA
Wed May 01 00:00:00 EDT 2013
Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells.
Stem cells (Dayton, Ohio)
Sun L,Mathews LA,Cabarcas SM,Zhang X,Yang A,Zhang Y,Young MR,Klarmann KD,Keller JR,Farrar WL
Thu Aug 01 00:00:00 EDT 2013
CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation.
Journal of immunology (Baltimore, Md. : 1950)
Giegold O,Ogrissek N,Richter C,Schröder M,Herrero San Juan M,Pfeilschifter JM,Radeke HH
Mon Apr 01 00:00:00 EDT 2013
STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.
Journal of immunology (Baltimore, Md. : 1950)
Rodríguez-Bayona B,Ramos-Amaya A,López-Blanco R,Campos-Caro A,Brieva JA
Fri Nov 15 00:00:00 EST 2013
CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation.
Journal of immunology (Baltimore, Md. : 1950)
Ponzetta A,Sciumè G,Benigni G,Antonangeli F,Morrone S,Santoni A,Bernardini G
Sun Dec 01 00:00:00 EST 2013
Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Stolp J,Mariño E,Batten M,Sierro F,Cox SL,Grey ST,Silveira PA
Mon Jul 01 00:00:00 EDT 2013
Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells.
PloS one
Don-Salu-Hewage AS,Chan SY,McAndrews KM,Chetram MA,Dawson MR,Bethea DA,Hinton CV
Tue Sep 10 00:00:00 EDT 2013
Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions.
The Journal of biological chemistry
Abbonante V,Gruppi C,Rubel D,Gross O,Moratti R,Balduini A
Fri Jun 07 00:00:00 EDT 2013
The decreased metastatic potential of rhabdomyosarcoma cells obtained through MET receptor downregulation and the induction of differentiation.
Cell death & disease
Miekus K,Lukasiewicz E,Jarocha D,Sekula M,Drabik G,Majka M
Thu Jan 17 00:00:00 EST 2013
The tandem PH domain-containing protein 2 (TAPP2) regulates chemokine-induced cytoskeletal reorganization and malignant B cell migration.
PloS one
Li H,Hou S,Wu X,Nandagopal S,Lin F,Kung S,Marshall AJ
Tue Sep 03 00:00:00 EDT 2013
Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function.
The Journal of biological chemistry
Blanchetot C,Verzijl D,Mujić-Delić A,Bosch L,Rem L,Leurs R,Verrips CT,Saunders M,de Haard H,Smit MJ
Fri Aug 30 00:00:00 EDT 2013
An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration.
The Journal of biological chemistry
Park BH,Kook S,Lee S,Jeong JH,Brufsky A,Lee BC
Fri Oct 04 00:00:00 EDT 2013
Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma.
PloS one
Xu J,Deng X,Tang M,Li L,Xiao L,Yang L,Zhong J,Bode AM,Dong Z,Tao Y,Cao Y
Tue Dec 03 00:00:00 EST 2013
KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.
Cell death & disease
D'Alessandro G,Catalano M,Sciaccaluga M,Chece G,Cipriani R,Rosito M,Grimaldi A,Lauro C,Cantore G,Santoro A,Fioretti B,Franciolini F,Wulff H,Limatola C
Thu Aug 15 00:00:00 EDT 2013
The human minor histocompatibility antigen 1 is a RhoGAP.
PloS one
de Kreuk BJ,Schaefer A,Anthony EC,Tol S,Fernandez-Borja M,Geerts D,Pool J,Hambach L,Goulmy E,Hordijk PL
300-28A was used in Sample Preparation (FC/FACS) to study how human minor Histocompatibility Antigen (HMHA1) acts as a RhoGAP to regulate GTPase activity, cytoskeletal remodeling and cell spreading, which are crucial functions in normal hematopoietic and cancer cells.
Fri Jul 18 00:00:00 EDT 2014
Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection.
Blood
Zoughlami Y,Voermans C,Brussen K,van Dort KA,Kootstra NA,Maussang D,Smit MJ,Hordijk PL,van Hennik PB
Thu Mar 01 00:00:00 EST 2012
Intrinsic impairment of CD4(+)CD25(+) regulatory T cells in acquired aplastic anemia.
Blood
Shi J,Ge M,Lu S,Li X,Shao Y,Huang J,Huang Z,Zhang J,Nie N,Zheng Y
Thu Aug 23 00:00:00 EDT 2012
Multiple myeloma-related deregulation of bone marrow-derived CD34(+) hematopoietic stem and progenitor cells.
Blood
Bruns I,Cadeddu RP,Brueckmann I,Fröbel J,Geyh S,Büst S,Fischer JC,Roels F,Wilk CM,Schildberg FA,Hünerlitürkoglu AN,Zilkens C,Jäger M,Steidl U,Zohren F,Fenk R,Kobbe G,Brors B,Czibere A,Schroeder T,Trumpp A,Haas R
Thu Sep 27 00:00:00 EDT 2012
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.
Blood
Will B,Zhou L,Vogler TO,Ben-Neriah S,Schinke C,Tamari R,Yu Y,Bhagat TD,Bhattacharyya S,Barreyro L,Heuck C,Mo Y,Parekh S,McMahon C,Pellagatti A,Boultwood J,Montagna C,Silverman L,Maciejewski J,Greally JM,Ye BH,List AF,Steidl C,Steidl U,Verma A
Thu Sep 06 00:00:00 EDT 2012
Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia.
Blood
O'Callaghan K,Lee L,Nguyen N,Hsieh MY,Kaneider NC,Klein AK,Sprague K,Van Etten RA,Kuliopulos A,Covic L
Thu Feb 16 00:00:00 EST 2012
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine
Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ
Mon Jan 16 00:00:00 EST 2012
Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion.
The Journal of cell biology
Rullo J,Becker H,Hyduk SJ,Wong JC,Digby G,Arora PD,Cano AP,Hartwig J,McCulloch CA,Cybulsky MI
Mon Apr 02 00:00:00 EDT 2012
Pulmonary CCL18 recruits human regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Chenivesse C,Chang Y,Azzaoui I,Ait Yahia S,Morales O,Plé C,Foussat A,Tonnel AB,Delhem N,Yssel H,Vorng H,Wallaert B,Tsicopoulos A
Sun Jul 01 00:00:00 EDT 2012
L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Freeley M,O'Dowd F,Paul T,Kashanin D,Davies A,Kelleher D,Long A
Fri Jun 15 00:00:00 EDT 2012
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Azcutia V,Stefanidakis M,Tsuboi N,Mayadas T,Croce KJ,Fukuda D,Aikawa M,Newton G,Luscinskas FW
Sat Sep 01 00:00:00 EDT 2012
CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients.
BMC medicine
Zhang SS,Han ZP,Jing YY,Tao SF,Li TJ,Wang H,Wang Y,Li R,Yang Y,Zhao X,Xu XD,Yu ED,Rui YC,Liu HJ,Zhang L,Wei LX
Tue Aug 07 00:00:00 EDT 2012
CXCR4 and vascular cell adhesion molecule 1 are key chemokine/adhesion receptors in the migration of cytokine-activated T cells.
Arthritis and rheumatism
Bryant J,Ahern DJ,Brennan FM
Sun Jul 01 00:00:00 EDT 2012
The balance between two isoforms of LEF-1 regulates colon carcinoma growth.
BMC gastroenterology
Wang SH,Nan KJ,Wang YC,Wang WJ,Tian T
Mon May 28 00:00:00 EDT 2012
Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12.
PloS one
McCaig AM,Cosimo E,Leach MT,Michie AM
Tue May 07 00:00:00 EDT 2013
Expression and Function of Ephrin-B1 and Its Cognate Receptor EphB2 in Human Abdominal Aortic Aneurysm.
International journal of vascular medicine
Sakamoto A,Kawashiri M,Ishibashi-Ueda H,Sugamoto Y,Yoshimuta T,Higashikata T,Ogino H,Tada H,Konno T,Hayashi K,Yamagishi M
Thu Aug 23 00:00:00 EDT 2012
CXCL12 and [N33A]CXCL12 in 5637 and HeLa cells: regulating HER1 phosphorylation via calmodulin/calcineurin.
PloS one
Rigo A,Gottardi M,Damiani E,Bonifacio M,Ferrarini I,Mauri P,Vinante F
Mon Nov 19 00:00:00 EST 2012
Evidence for chemokine-mediated coalescence of preformed flotillin hetero-oligomers in human T-cells.
The Journal of biological chemistry
Baumann T,Affentranger S,Niggli V
Fri Nov 16 00:00:00 EST 2012
Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues.
The Journal of biological chemistry
Hoffmann F,Müller W,Schütz D,Penfold ME,Wong YH,Schulz S,Stumm R
Fri Aug 17 00:00:00 EDT 2012
Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.
The Journal of biological chemistry
Malik R,Soh UJ,Trejo J,Marchese A
Fri Mar 16 00:00:00 EDT 2012
A multi-functional imaging approach to high-content protein interaction screening.
PloS one
Matthews DR,Fruhwirth GO,Weitsman G,Carlin LM,Ofo E,Keppler M,Barber PR,Tullis ID,Vojnovic B,Ng T,Ameer-Beg SM
Wed Oct 17 00:00:00 EDT 2012
A multi-functional imaging approach to high-content protein interaction screening.
PloS one
Matthews DR,Fruhwirth GO,Weitsman G,Carlin LM,Ofo E,Keppler M,Barber PR,Tullis ID,Vojnovic B,Ng T,Ameer-Beg SM
Wed Oct 17 00:00:00 EDT 2012
Isolation and characterization of two kinds of stem cells from the same human skin back sample with therapeutic potential in spinal cord injury.
PloS one
Zong Z,Li N,Ran X,Su Y,Shen Y,Shi CM,Cheng TM
Mon May 20 00:00:00 EDT 2013
Ubiquitination of CXCR7 controls receptor trafficking.
PloS one
Canals M,Scholten DJ,de Munnik S,Han MK,Smit MJ,Leurs R
Fri Aug 03 00:00:00 EDT 2012
Differential regulation of bone marrow-derived endothelial progenitor cells and endothelial outgrowth cells by the Notch signaling pathway.
PloS one
Chen JY,Feng L,Zhang HL,Li JC,Yang XW,Cao XL,Liu L,Qin HY,Liang YM,Han H
Thu May 09 00:00:00 EDT 2013
Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells.
Journal of translational medicine
Heinrich EL,Lee W,Lu J,Lowy AM,Kim J
Mon Apr 02 00:00:00 EDT 2012
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.
PloS one
Liberman J,Sartelet H,Flahaut M,Mühlethaler-Mottet A,Coulon A,Nyalendo C,Vassal G,Joseph JM,Gross N
Wed Jan 16 00:00:00 EST 2013
Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.
PloS one
Costantino CM,Gupta A,Yewdall AW,Dale BM,Devi LA,Chen BK
Mon Aug 20 00:00:00 EDT 2012
CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma.
PloS one
Rao S,Sengupta R,Choe EJ,Woerner BM,Jackson E,Sun T,Leonard J,Piwnica-Worms D,Rubin JB
Mon Aug 20 00:00:00 EDT 2012
CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma.
PloS one
Rao S,Sengupta R,Choe EJ,Woerner BM,Jackson E,Sun T,Leonard J,Piwnica-Worms D,Rubin JB
Mon Aug 20 00:00:00 EDT 2012
The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells.
PloS one
Kayali AG,Lopez AD,Hao E,Hinton A,Hayek A,King CC
Tue Mar 26 00:00:00 EDT 2013
Differential adhesive properties of sequestered asexual and sexual stages of Plasmodium falciparum on human endothelial cells are tissue independent.
PloS one
Silvestrini F,Tibúrcio M,Bertuccini L,Alano P
Fri Jun 29 00:00:00 EDT 2012
Stepwise optimization of the procedure for assessment of circulating progenitor cells in patients with myocardial infarction.
PloS one
Cui YX,Johnson T,Baumbach A,Reeves BC,Rogers CA,Angelini GD,Marsden D,Madeddu P
Mon Jun 11 00:00:00 EDT 2012
Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy.
Blood
Chao MP,Tang C,Pachynski RK,Chin R,Majeti R,Weissman IL
Thu Nov 03 00:00:00 EDT 2011
Extracellular matrix structure and nano-mechanics determine megakaryocyte function.
Blood
Malara A,Gruppi C,Pallotta I,Spedden E,Tenni R,Raspanti M,Kaplan D,Tira ME,Staii C,Balduini A
Thu Oct 20 00:00:00 EDT 2011
CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow.
Blood
Sciumè G,De Angelis G,Benigni G,Ponzetta A,Morrone S,Santoni A,Bernardini G
Thu Apr 28 00:00:00 EDT 2011
Active scaffolds for on-demand drug and cell delivery.
Proceedings of the National Academy of Sciences of the United States of America
Zhao X,Kim J,Cezar CA,Huebsch N,Lee K,Bouhadir K,Mooney DJ
Tue Jan 04 00:00:00 EST 2011
Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor.
PLoS pathogens
Xue X,Lu Q,Wei H,Wang D,Chen D,He G,Huang L,Wang H,Wang X
Fri Jul 01 00:00:00 EDT 2011
CXCL12-mediated regulation of ANP32A/Lanp, a component of the inhibitor of histone acetyl transferase (INHAT) complex, in cortical neurons.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Khan MZ,Vaidya A,Meucci O
Tue Mar 01 00:00:00 EST 2011
Combined effects of hematopoietic progenitor cell mobilization from bone marrow by granulocyte colony stimulating factor and AMD3100 and chemotaxis into the brain using stromal cell-derived factor-1α in an Alzheimer's disease mouse model.
Stem cells (Dayton, Ohio)
Shin JW,Lee JK,Lee JE,Min WK,Schuchman EH,Jin HK,Bae JS
Fri Jul 01 00:00:00 EDT 2011
Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation.
Journal of immunology (Baltimore, Md. : 1950)
Hyduk SJ,Rullo J,Cano AP,Xiao H,Chen M,Moser M,Cybulsky MI
Sat Oct 15 00:00:00 EDT 2011
Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration.
Journal of immunology (Baltimore, Md. : 1950)
Schaeuble K,Hauser MA,Singer E,Groettrup M,Legler DF
Thu Dec 01 00:00:00 EST 2011
CXCR4 expression on activated B cells is downregulated by CD63 and IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Yoshida N,Kitayama D,Arima M,Sakamoto A,Inamine A,Watanabe-Takano H,Hatano M,Koike T,Tokuhisa T
Tue Mar 01 00:00:00 EST 2011
Agonists for the Chemokine Receptor CXCR4.
ACS medicinal chemistry letters
Lefrançois M,Lefebvre MR,Saint-Onge G,Boulais PE,Lamothe S,Leduc R,Lavigne P,Heveker N,Escher E
Thu Aug 11 00:00:00 EDT 2011
The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions.
The Journal of biological chemistry
Saini V,Staren DM,Ziarek JJ,Nashaat ZN,Campbell EM,Volkman BF,Marchese A,Majetschak M
Fri Sep 23 00:00:00 EDT 2011
Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV-1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines.
Virology journal
Bolton MJ,Garry RF
Mon Jan 31 00:00:00 EST 2011
Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin.
PloS one
Greene TA,Alarcon S,Thomas A,Berdougo E,Doranz BJ,Breslin PA,Rucker JB
Fri Sep 23 00:00:00 EDT 2011
Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction.
The Journal of biological chemistry
Saini V,Marchese A,Tang WJ,Majetschak M
Fri Dec 23 00:00:00 EST 2011
Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation.
The Journal of biological chemistry
Fang JD,Chou HC,Tung HH,Huang PY,Lee SL
Fri Feb 18 00:00:00 EST 2011
Host chemokines bind to Staphylococcus aureus and stimulate protein A release.
The Journal of biological chemistry
Yung SC,Parenti D,Murphy PM
Fri Feb 18 00:00:00 EST 2011
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
Nature communications
de la Vega M,Kelvin AA,Dunican DJ,McFarlane C,Burrows JF,Jaworski J,Stevenson NJ,Dib K,Rappoport JZ,Scott CJ,Long A,Johnston JA
Tue Mar 29 00:00:00 EDT 2011
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.
Blood cancer journal
Skavland J,Jørgensen KM,Hadziavdic K,Hovland R,Jonassen I,Bruserud O,Gjertsen BT
Tue Feb 01 00:00:00 EST 2011
Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes.
BMC cell biology
Affentranger S,Martinelli S,Hahn J,Rossy J,Niggli V
Wed Jun 22 00:00:00 EDT 2011
Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendritic cells.
The Journal of biological chemistry
Delgado-Martín C,Escribano C,Pablos JL,Riol-Blanco L,Rodríguez-Fernández JL
Fri Oct 28 00:00:00 EDT 2011
Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.
PloS one
Jham BC,Ma T,Hu J,Chaisuparat R,Friedman ER,Pandolfi PP,Schneider A,Sodhi A,Montaner S
Fri Apr 29 00:00:00 EDT 2011
SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration.
Molecular vision
Thill M,Berna MJ,Kunst F,Wege H,Strunnikova NV,Gordiyenko N,Grierson R,Richard G,Csaky KG
Mon Jan 10 00:00:00 EST 2011
Involvement of mTOR in CXCL12 mediated T cell signaling and migration.
PloS one
Munk R,Ghosh P,Ghosh MC,Saito T,Xu M,Carter A,Indig F,Taub DD,Longo DL
Tue Feb 28 00:00:00 EST 2012
Involvement of mTOR in CXCL12 mediated T cell signaling and migration.
PloS one
Munk R,Ghosh P,Ghosh MC,Saito T,Xu M,Carter A,Indig F,Taub DD,Longo DL
Tue Feb 28 00:00:00 EST 2012
The level of CD147 expression correlates with cyclophilin-induced signalling and chemotaxis.
BMC research notes
Trachtenberg A,Pushkarsky T,Heine S,Constant S,Brichacek B,Bukrinsky M
Tue Oct 11 00:00:00 EDT 2011
Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion.
PloS one
Nasser MW,Qamri Z,Deol YS,Smith D,Shilo K,Zou X,Ganju RK
Tue Feb 14 00:00:00 EST 2012
CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration.
The Journal of biological chemistry
Décaillot FM,Kazmi MA,Lin Y,Ray-Saha S,Sakmar TP,Sachdev P
Fri Sep 16 00:00:00 EDT 2011
HS1 has a central role in the trafficking and homing of leukemic B cells.
Blood
Scielzo C,Bertilaccio MT,Simonetti G,Dagklis A,ten Hacken E,Fazi C,Muzio M,Caiolfa V,Kitamura D,Restuccia U,Bachi A,Rocchi M,Ponzoni M,Ghia P,Caligaris-Cappio F
Thu Nov 04 00:00:00 EDT 2010
Iron control of erythroid development by a novel aconitase-associated regulatory pathway.
Blood
Bullock GC,Delehanty LL,Talbot AL,Gonias SL,Tong WH,Rouault TA,Dewar B,Macdonald JM,Chruma JJ,Goldfarb AN
Thu Jul 08 00:00:00 EDT 2010
Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists.
Blood
Mandawat A,Fiskus W,Buckley KM,Robbins K,Rao R,Balusu R,Navenot JM,Wang ZX,Ustun C,Chong DG,Atadja P,Fujii N,Peiper SC,Bhalla K
Thu Dec 09 00:00:00 EST 2010
ATP secreted by endothelial cells blocks CX₃CL 1-elicited natural killer cell chemotaxis and cytotoxicity via P2Y₁₁ receptor activation.
Blood
Gorini S,Callegari G,Romagnoli G,Mammi C,Mavilio D,Rosano G,Fini M,Di Virgilio F,Gulinelli S,Falzoni S,Cavani A,Ferrari D,la Sala A
Thu Nov 25 00:00:00 EST 2010
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America
Tchernychev B,Ren Y,Sachdev P,Janz JM,Haggis L,O'Shea A,McBride E,Looby R,Deng Q,McMurry T,Kazmi MA,Sakmar TP,Hunt S,Carlson KE
Tue Dec 21 00:00:00 EST 2010
Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium.
Immunology
McGettrick HM,Buckley CD,Filer A,Rainger GE,Nash GB
Mon Nov 01 00:00:00 EDT 2010
Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function.
Stem cells (Dayton, Ohio)
Sordi V,Melzi R,Mercalli A,Formicola R,Doglioni C,Tiboni F,Ferrari G,Nano R,Chwalek K,Lammert E,Bonifacio E,Borg D,Piemonti L
Fri Jan 01 00:00:00 EST 2010
Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients.
Arthritis research & therapy
Rodríguez-Bayona B,Ramos-Amaya A,Pérez-Venegas JJ,Rodríguez C,Brieva JA
Wed Nov 24 00:00:00 EST 2010
CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response.
Journal of immunology (Baltimore, Md. : 1950)
Zhang HH,Song K,Rabin RL,Hill BJ,Perfetto SP,Roederer M,Douek DC,Siegel RM,Farber JM
Wed Dec 01 00:00:00 EST 2010
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
Journal of immunology (Baltimore, Md. : 1950)
Röhrl J,Yang D,Oppenheim JJ,Hehlgans T
Tue Jun 15 00:00:00 EDT 2010
Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients.
Journal of immunology (Baltimore, Md. : 1950)
Madigan J,Freeman DJ,Menzies F,Forrow S,Nelson SM,Young A,Sharkey A,Moffett A,Graham GJ,Greer IA,Rot A,Nibbs RJ
Mon Mar 15 00:00:00 EDT 2010
Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12.
Molecular cancer
Rigo A,Gottardi M,Zamò A,Mauri P,Bonifacio M,Krampera M,Damiani E,Pizzolo G,Vinante F
Thu Oct 14 00:00:00 EDT 2010
Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1alpha.
BMC neuroscience
Wang F,Yasuhara T,Shingo T,Kameda M,Tajiri N,Yuan WJ,Kondo A,Kadota T,Baba T,Tayra JT,Kikuchi Y,Miyoshi Y,Date I
Mon Apr 26 00:00:00 EDT 2010
Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells.
Journal of experimental & clinical cancer research : CR
Zheng K,Li HY,Su XL,Wang XY,Tian T,Li F,Ren GS
Sun Apr 11 00:00:00 EDT 2010
Differentiation of human T cells alters their repertoire of G protein alpha-subunits.
The Journal of biological chemistry
Foley JF,Singh SP,Cantu M,Chen L,Zhang HH,Farber JM
Fri Nov 12 00:00:00 EST 2010
AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.
The Journal of biological chemistry
Sierra MI,Wright MH,Nash PD
Fri Apr 30 00:00:00 EDT 2010
The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Gαi proteins, and constitutively impairs CXCR4 functioning.
The Journal of biological chemistry
Nijmeijer S,Leurs R,Smit MJ,Vischer HF
Fri Sep 17 00:00:00 EDT 2010
Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons.
The Journal of biological chemistry
Cook A,Hippensteel R,Shimizu S,Nicolai J,Fatatis A,Meucci O
Fri Apr 02 00:00:00 EDT 2010
The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains.
The Journal of biological chemistry
Gravel S,Malouf C,Boulais PE,Berchiche YA,Oishi S,Fujii N,Leduc R,Sinnett D,Heveker N
Fri Dec 03 00:00:00 EST 2010
An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigenesis.
PloS one
Jin G,Kawsar HI,Hirsch SA,Zeng C,Jia X,Feng Z,Ghosh SK,Zheng QY,Zhou A,McIntyre TM,Weinberg A
Tue Jun 08 00:00:00 EDT 2010
Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes.
PloS one
Zhukovsky MA,Basmaciogullari S,Pacheco B,Wang L,Madani N,Haim H,Sodroski J
Wed Oct 13 00:00:00 EDT 2010
The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor 4 at the sorting endosome.
The Journal of biological chemistry
Berlin I,Higginbotham KM,Dise RS,Sierra MI,Nash PD
Fri Nov 26 00:00:00 EST 2010
CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin.
The Journal of biological chemistry
Saini V,Marchese A,Majetschak M
Fri May 14 00:00:00 EDT 2010
T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
PloS one
Berge T,Sundvold-Gjerstad V,Granum S,Andersen TC,Holthe GB,Claesson-Welsh L,Andreotti AH,Inngjerdingen M,Spurkland A
Thu Mar 18 00:00:00 EDT 2010
Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk.
Molecular cancer
Rhodes LV,Antoon JW,Muir SE,Elliott S,Beckman BS,Burow ME
Thu Nov 18 00:00:00 EST 2010
An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression.
Blood
Trinidad EM,Ballesteros M,Zuloaga J,Zapata A,Alonso-Colmenar LM
Thu Dec 03 00:00:00 EST 2009
Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck.
Blood
Ghosh MC,Baatar D,Collins G,Carter A,Indig F,Biragyn A,Taub DD
Thu Jan 15 00:00:00 EST 2009
TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia.
Blood
Costantini JL,Cheung SM,Hou S,Li H,Kung SK,Johnston JB,Wilkins JA,Gibson SB,Marshall AJ
Thu Nov 19 00:00:00 EST 2009
HIV-1 Tat and heparan sulfate proteoglycan interaction: a novel mechanism of lymphocyte adhesion and migration across the endothelium.
Blood
Urbinati C,Nicoli S,Giacca M,David G,Fiorentini S,Caruso A,Alfano M,Cassetta L,Presta M,Rusnati M
Thu Oct 08 00:00:00 EDT 2009
Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration.
Blood
Ghosh MC,Collins GD,Vandanmagsar B,Patel K,Brill M,Carter A,Lustig A,Becker KG,Wood WW,Emeche CD,French AD,O'Connell MP,Xu M,Weeraratna AT,Taub DD
Thu Aug 13 00:00:00 EDT 2009
CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway.
Blood
Gollmer K,Asperti-Boursin F,Tanaka Y,Okkenhaug K,Vanhaesebroeck B,Peterson JR,Fukui Y,Donnadieu E,Stein JV
Thu Jul 16 00:00:00 EDT 2009
Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice.
Blood
Kawaguchi A,Orba Y,Kimura T,Iha H,Ogata M,Tsuji T,Ainai A,Sata T,Okamoto T,Hall WW,Sawa H,Hasegawa H
Thu Oct 01 00:00:00 EDT 2009
MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.
The Journal of clinical investigation
Vagima Y,Avigdor A,Goichberg P,Shivtiel S,Tesio M,Kalinkovich A,Golan K,Dar A,Kollet O,Petit I,Perl O,Rosenthal E,Resnick I,Hardan I,Gellman YN,Naor D,Nagler A,Lapidot T
Sun Mar 01 00:00:00 EST 2009
p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1alpha-directed migration in chronic myeloid leukemia cells.
Oncogene
Chang YC,Tien SC,Tien HF,Zhang H,Bokoch GM,Chang ZF
Thu Nov 19 00:00:00 EST 2009
Src family kinases are necessary for cell migration induced by extracellular HMGB1.
Journal of leukocyte biology
Palumbo R,De Marchis F,Pusterla T,Conti A,Alessio M,Bianchi ME
Tue Sep 01 00:00:00 EDT 2009
Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration.
Journal of leukocyte biology
McGettrick HM,Hunter K,Moss PA,Buckley CD,Rainger GE,Nash GB
Thu Jan 01 00:00:00 EST 2009
Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis.
Arthritis research & therapy
Nanki T,Takada K,Komano Y,Morio T,Kanegane H,Nakajima A,Lipsky PE,Miyasaka N
Wed Feb 03 00:00:00 EST 2010
Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells.
Journal of immunology (Baltimore, Md. : 1950)
Sekine Y,Ikeda O,Tsuji S,Yamamoto C,Muromoto R,Nanbo A,Oritani K,Yoshimura A,Matsuda T
Tue Dec 15 00:00:00 EST 2009
Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4.
Journal of immunology (Baltimore, Md. : 1950)
Schneider OD,Weiss AA,Miller WE
Fri May 01 00:00:00 EDT 2009
A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.
Journal of immunology (Baltimore, Md. : 1950)
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Human cytomegalovirus paralyzes macrophage motility through down-regulation of chemokine receptors, reorganization of the cytoskeleton, and release of macrophage migration inhibitory factor.
Journal of immunology (Baltimore, Md. : 1950)
Frascaroli G,Varani S,Blankenhorn N,Pretsch R,Bacher M,Leng L,Bucala R,Landini MP,Mertens T
Thu Jan 01 00:00:00 EST 2009
SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.
PloS one
Egesten A,Olin AI,Linge HM,Yadav M,Mörgelin M,Karlsson A,Collin M
Mon Jun 15 00:00:00 EDT 2009
Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor.
PloS one
McCormick PJ,Segarra M,Gasperini P,Gulino AV,Tosato G
Tue Dec 01 00:00:00 EST 2009
Photo-activation of the hydrophobic probe iodonaphthylazide in cells alters membrane protein function leading to cell death.
BMC cell biology
Viard M,Garg H,Blumenthal R,Raviv Y
Thu Mar 26 00:00:00 EDT 2009
Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation.
The Journal of biological chemistry
Mines MA,Goodwin JS,Limbird LE,Cui FF,Fan GH
Fri Feb 27 00:00:00 EST 2009
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Nature immunology
Shiow LR,Roadcap DW,Paris K,Watson SR,Grigorova IL,Lebet T,An J,Xu Y,Jenne CN,Föger N,Sorensen RU,Goodnow CC,Bear JE,Puck JM,Cyster JG
Sat Nov 01 00:00:00 EDT 2008
Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization?
Stem cells (Dayton, Ohio)
Marquez-Curtis L,Jalili A,Deiteren K,Shirvaikar N,Lambeir AM,Janowska-Wieczorek A
Thu May 01 00:00:00 EDT 2008
Bone marrow-derived dendritic cells generated in the presence of resolvin E1 induce apoptosis of activated CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Vassiliou EK,Kesler OM,Tadros JH,Ganea D
Wed Oct 01 00:00:00 EDT 2008
Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Lee J,Hillsamer P,Kim CH
Tue Jan 01 00:00:00 EST 2008
Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase.
Journal of immunology (Baltimore, Md. : 1950)
Malik M,Chen YY,Kienzle MF,Tomkowicz BE,Collman RG,Ptasznik A
Wed Oct 01 00:00:00 EDT 2008
Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue.
The Journal of biological chemistry
Ito A,Suganami T,Yamauchi A,Degawa-Yamauchi M,Tanaka M,Kouyama R,Kobayashi Y,Nitta N,Yasuda K,Hirata Y,Kuziel WA,Takeya M,Kanegasaki S,Kamei Y,Ogawa Y
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Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag.
Virology journal
Valiathan RR,Resh MD
Mon Feb 11 00:00:00 EST 2008
Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo.
Cancer research
Yang L,Jackson E,Woerner BM,Perry A,Piwnica-Worms D,Rubin JB
Mon Jan 15 00:00:00 EST 2007
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
Proceedings of the National Academy of Sciences of the United States of America
Miao Z,Luker KE,Summers BC,Berahovich R,Bhojani MS,Rehemtulla A,Kleer CG,Essner JJ,Nasevicius A,Luker GD,Howard MC,Schall TJ
Tue Oct 02 00:00:00 EDT 2007
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
Proceedings of the National Academy of Sciences of the United States of America
Miao Z,Luker KE,Summers BC,Berahovich R,Bhojani MS,Rehemtulla A,Kleer CG,Essner JJ,Nasevicius A,Luker GD,Howard MC,Schall TJ
Tue Oct 02 00:00:00 EDT 2007
The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.
Stem cells (Dayton, Ohio)
Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J
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Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors.
Stem cells (Dayton, Ohio)
Honczarenko M,Le Y,Swierkowski M,Ghiran I,Glodek AM,Silberstein LE
Sat Apr 01 00:00:00 EST 2006
CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Cappello P,Fraone T,Barberis L,Costa C,Hirsch E,Elia AR,Caorsi C,Musso T,Novelli F,Giovarelli M
Wed Nov 01 00:00:00 EST 2006
Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity.
Journal of immunology (Baltimore, Md. : 1950)
Cuss AK,Avery DT,Cannons JL,Yu LJ,Nichols KE,Shaw PJ,Tangye SG
Wed Feb 01 00:00:00 EST 2006
Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.
The Journal of biological chemistry
Fox JM,Najarro P,Smith GL,Struyf S,Proost P,Pease JE
Fri Dec 01 00:00:00 EST 2006
Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor.
The EMBO journal
Rodríguez-Frade JM,del Real G,Serrano A,Hernanz-Falcón P,Soriano SF,Vila-Coro AJ,de Ana AM,Lucas P,Prieto I,Martínez-A C,Mellado M
Wed Jan 14 00:00:00 EST 2004
CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.
The Journal of clinical investigation
Kunkel EJ,Kim CH,Lazarus NH,Vierra MA,Soler D,Bowman EP,Butcher EC
Tue Apr 01 00:00:00 EST 2003
CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor.
Blood
Honczarenko M,Le Y,Glodek AM,Majka M,Campbell JJ,Ratajczak MZ,Silberstein LE
Tue Oct 01 00:00:00 EDT 2002
Hematopoietic stem cells are uniquely selective in their migratory response to chemokines.
The Journal of experimental medicine
Wright DE,Bowman EP,Wagers AJ,Butcher EC,Weissman IL
Mon May 06 00:00:00 EDT 2002
The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells.
The Journal of experimental medicine
Bowman EP,Kuklin NA,Youngman KR,Lazarus NH,Kunkel EJ,Pan J,Greenberg HB,Butcher EC
Mon Jan 21 00:00:00 EST 2002
Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages.
The Journal of biological chemistry
Wang J,Guan E,Roderiquez G,Calvert V,Alvarez R,Norcross MA
Fri Dec 28 00:00:00 EST 2001
Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain.
The Journal of biological chemistry
Tiffany HL,Lavigne MC,Cui YH,Wang JM,Leto TL,Gao JL,Murphy PM
Fri Jun 29 00:00:00 EDT 2001
The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro.
Stem cells (Dayton, Ohio)
Majka M,Ratajczak J,Lee B,Honczarenko M,Douglas R,Kowalska MA,Silberstein L,Gewirtz AM,Ratajczak MZ
Mon Jun 26 00:00:00 EDT 2000
A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.
The Journal of biological chemistry
Sabroe I,Peck MJ,Van Keulen BJ,Jorritsma A,Simmons G,Clapham PR,Williams TJ,Pease JE
Fri Aug 25 00:00:00 EDT 2000
A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.
The Journal of biological chemistry
Sabroe I,Peck MJ,Van Keulen BJ,Jorritsma A,Simmons G,Clapham PR,Williams TJ,Pease JE
Fri Aug 25 00:00:00 EDT 2000
Disturbed CD4+ T cell homeostasis and in vitro HIV-1 susceptibility in transgenic mice expressing T cell line-tropic HIV-1 receptors.
The Journal of experimental medicine
Sawada S,Gowrishankar K,Kitamura R,Suzuki M,Suzuki G,Tahara S,Koito A
Mon May 04 00:00:00 EDT 1998
HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.
Journal of immunology (Baltimore, Md. : 1950)
Wang JM,Ueda H,Howard OM,Grimm MC,Chertov O,Gong X,Gong W,Resau JH,Broder CC,Evans G,Arthur LO,Ruscetti FW,Oppenheim JJ
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