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Invitrogen
Human DENND5A (aa 815-867) Control Fragment Recombinant Protein
Product Details
RP-100832
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
SALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQD
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (92%), Rat (92%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-63049. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
DENND5A (DENN domain-containing protein 5A) is a guanine nucleotide exchange factor (GEF) which activates RAB6A and RAB39A/RAB39B. It promotes the exchange of GDP to GTP by converting inactive GDP-bound Rab proteins to their active GTP form. DENND5A is also involved in the negative regulation of neurtie outgrowth. Mutations affecting this gene can result in epileptic encephalopathy, early infantile, 49 (EIEE49).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DENN domain-containing protein 5A; DENN/MADD domain containing 5A; RAB6 interacting protein 1; Rab6-interacting protein 1; Rab6IP1
Gene Aliases: DENND5A; KIAA1091; RAB6IP1
UniProt ID: (Human) Q6IQ26
Entrez Gene ID: (Human) 23258
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