Product References
Isolation and Functional Analysis of Myoepithelial Cells from Adult Mouse Submandibular Glands.
Methods in molecular biology (Clifton, N.J.)
Yasuhara R,Kang S,Tokumasu R,Mishima K
AF-100-15 was used in Cell Culture to describe detailed methods and tips for the isolation and functional analysis of myoepithelial cells.
Wed Nov 08 00:00:00 EST 2023
Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1.
Molecular psychiatry
Schäffner I,Wittmann MT,Vogel T,Lie DC
AF-100-15 was used in Cell Culture to reveal differential vulnerability of neuronal subtypes to increased FOXG1 dosage and suggest that activity of a FOXG1/NR4A1 axis contributes to such subtype-specific response.
Sun Jan 01 00:00:00 EST 2023
The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor.
Frontiers in molecular neuroscience
Knorr DY,Rodriguez Polo I,Pies HS,Schwedhelm-Domeyer N,Pauls S,Behr R,Heinrich R
AF-100-15 was used in Cell Culture to show that the human CRLF3 mediates neuroprotection upon activation with the natural Epo splice variant EV-3.
Sun May 14 00:00:00 EDT 2023
Spatially controlled construction of assembloids using bioprinting.
Nature communications
Roth JG,Brunel LG,Huang MS,Liu Y,Cai B,Sinha S,Yang F,Pașca SP,Shin S,Heilshorn SC
AF-100-15 was used in Cell Culture to demonstrate the potential for the SPOT platform to construct assembloids which recapitulate key developmental processes and disease etiologies.
Wed Jul 19 00:00:00 EDT 2023
Simultaneous establishment of pancreatic cancer organoid and cancer-associated fibroblast using a single-pass endoscopic ultrasound-guided fine-needle biopsy specimen.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Kim S,Woo KJ,Yang CM,Park SH,Hwang JC,Yoo BM,Kim JH,Lee D,Yang MJ
AF-100-15 was used in Cell Culture to demonstrate that the coestablishment of PDOs and CAFs is feasible even with a single-pass EUS-FNB sample, implying an expanding role of endoscopists in future precision medicine.
Wed Nov 01 00:00:00 EDT 2023
A simplified and defined serum-free medium for cultivating fat across species.
iScience
Mitić R,Cantoni F,Börlin CS,Post MJ,Jackisch L
AF-100-15 was used in Cell Culture to propose a simplified one-step adipogenic protocol which, given the replacement of rosiglitazone by a food-compatible PPARγ agonist, is suitable for making cultivated fat.
Fri Jan 20 00:00:00 EST 2023
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Nature communications
Chen Y,Chen L,Wu X,Zhao Y,Wang Y,Jiang D,Liu X,Zhou T,Li S,Wei Y,Liu Y,Hu C,Zhou B,Qin J,Ying H,Ding Q
AF-100-15 was used in In vitro experiments to identify an epigenetic mechanism by which the early phase lipid redistribution from adipose tissue to liver during regeneration impacts hepatocyte proliferation, and suggest a potential strategy to boost liver regeneration.
Sat Mar 18 00:00:00 EDT 2023
Protocol to generate cardiac pericytes from human induced pluripotent stem cells.
STAR protocols
Shen M,Zhao SR,Khokhar Y,Li L,Zhou Y,Liu C,Wu JC
AF-100-15 was used in Cell Culture to present a protocol to generate them from human induced pluripotent stem cells (hiPSCs).
Thu Apr 27 00:00:00 EDT 2023
Transcription Factor-Mediated Differentiation of Motor Neurons from Human Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Wu J,Tang Y
AF-100-15 was used in Cell Culture to describe a method of generating functional MNs via lentiviral delivery of transcription factors, based on the preservable NPC platform derived from hPSCs.
Thu Dec 15 00:00:00 EST 2022
An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming.
Science advances
Weng M,Hu H,Graus MS,Tan DS,Gao Y,Ren S,Ho DHH,Langer J,Holzner M,Huang Y,Ling GS,Lai CSW,Francois M,Jauch R
AF-100-15 was used in Cell Culture to report iNSC reprogramming from embryonic and aged mouse fibroblasts as well as from human blood using an engineered Sox17 (eSox17FNV).
Fri Aug 25 00:00:00 EDT 2023
Derivation and Primordial Germ Cell Induction of Intermediate Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Yu L,Ballard E,Pinzon Arteaga CA,Wu J
AF-100-15 was used in In vitro experiments to describe the method for derivation and maintenance of mouse and human FTW-PSCs, as well as PGC-LC induction from FTW-PSCs.
Fri Jul 21 00:00:00 EDT 2023
Structural elements promote architectural stripe formation and facilitate ultra-long-range gene regulation at a human disease locus.
Molecular cell
Chen LF,Long HK,Park M,Swigut T,Boettiger AN,Wysocka J
AF-100-15 was used in In vitro experiments to provide mechanistic insights into architectural stripe formation and gene regulation over ultra-long genomic ranges.
Thu May 04 00:00:00 EDT 2023
Precise modulation of transcription factor levels identifies features underlying dosage sensitivity.
Nature genetics
Naqvi S,Kim S,Hoskens H,Matthews HS,Spritz RA,Klein OD,Hallgrímsson B,Swigut T,Claes P,Pritchard JK,Wysocka J
AF-100-15 was used in In vitro experiments to propose that such REs and genes underlie the sensitivity of specific phenotypes to TF dosage, while buffering of other genes leads to robust, nonlinear dosage-to-phenotype relationships.
Mon May 01 00:00:00 EDT 2023
Targeting intratumor heterogeneity suppresses colorectal cancer chemoresistance and metastasis.
EMBO reports
Chao S,Zhang F,Yan H,Wang L,Zhang L,Wang Z,Xue R,Wang L,Wu Z,Jiang B,Shi G,Xue Y,Du J,Bu P
AF-100-15 was used in Cell Culture to demonstrate that asymmetric division of CCSCs contributes to the early establishment of ITH.
Thu Aug 03 00:00:00 EDT 2023
Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2.
iScience
Flamier A,Bisht P,Richards A,Tomasello DL,Jaenisch R
AF-100-15 was used in In vitro experiments to indicate that sensory neurons can be infected by the original WA1/2020 strain of SARS-CoV-2 as well as the delta and omicron variants, yet infectability differs between the original strain and the variants.
Fri Sep 15 00:00:00 EDT 2023
Generating human blastoids modeling blastocyst-stage embryos and implantation.
Nature protocols
Heidari Khoei H,Javali A,Kagawa H,Sommer TM,Sestini G,David L,Slovakova J,Novatchkova M,Scholte Op Reimer Y,Rivron N
AF-100-15 was used in Cell Culture to describe how we formed human blastoids that (1) efficiently achieve the morphology of the blastocyst and (2) form lineages according to the pace and sequence of blastocyst development, (3) ultimately forming cells that transcriptionally reflect the blastocyst (preimplantation stage).
Mon May 01 00:00:00 EDT 2023
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.
Cell research
Gu Y,Cao J,Zhang X,Gao H,Wang Y,Wang J,He J,Jiang X,Zhang J,Shen G,Yang J,Zheng X,Hu G,Zhu Y,Du S,Zhu Y,Zhang R,Xu J,Lan F,Qu D,Xu G,Zhao Y,Gao D,Xie Y,Luo M,Lu Z
Sat Jan 01 00:00:00 EST 2022
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.
The Journal of experimental medicine
Khalil BD,Sanchez R,Rahman T,Rodriguez-Tirado C,Moritsch S,Martinez AR,Miles B,Farias E,Mezei M,Nobre AR,Singh D,Kale N,Sproll KC,Sosa MS,Aguirre-Ghiso JA
Mon Jan 03 00:00:00 EST 2022
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer.
The Journal of experimental medicine
Masetti M,Carriero R,Portale F,Marelli G,Morina N,Pandini M,Iovino M,Partini B,Erreni M,Ponzetta A,Magrini E,Colombo P,Elefante G,Colombo FS,den Haan JMM,Peano C,Cibella J,Termanini A,Kunderfranco P,Brummelman J,Chung MWH,Lazzeri M,Hurle R,Casale P,Lugli E,DePinho RA,Mukhopadhyay S,Gordon S,Di Mitri D
Mon Feb 07 00:00:00 EST 2022
Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.
Hepatology (Baltimore, Md.)
Amarachintha SP,Mourya R,Ayabe H,Yang L,Luo Z,Li X,Thanekar U,Shivakumar P,Bezerra JA
Sat Jan 01 00:00:00 EST 2022
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.
The EMBO journal
Sun D,Llora Batlle O,van den Ameele J,Thomas JC,He P,Lim K,Tang W,Xu C,Meyer KB,Teichmann SA,Marioni JC,Jackson SP,Brand AH,Rawlins EL
AF-100-15 was used in Cell Culture to establish a new workflow for using primary human organoids to elucidate detailed functional mechanisms underlying normal development and disease.
Wed Nov 02 00:00:00 EDT 2022
Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer.
Cancer immunology research
Gil Del Alcazar CR,Trinh A,Alečković M,Rojas Jimenez E,Harper NW,Oliphant MUJ,Xie S,Krop ED,Lulseged B,Murphy KC,Keenan TE,Van Allen EM,Tolaney SM,Freeman GJ,Dillon DA,Muthuswamy SK,Polyak K
AF-100-15 was used in Tissue/organ culture to address how there are no good murine models of estrogen receptor-positive (ER+) breast cancer and demonstrate that Nitroso-N-methylurea-induced mammary tumors in outbred Sprague-Dawley rats recapitulate the heterogeneity for mutational profiles, ER expression, and immune evasive mechanisms observed in human breast cancer.
Fri Jun 03 00:00:00 EDT 2022
Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles.
Advanced healthcare materials
Evers MJW,van de Wakker SI,de Groot EM,de Jong OG,Gitz-François JJJ,Seinen CS,Sluijter JPG,Schiffelers RM,Vader P
Tue Mar 01 00:00:00 EST 2022
Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies.
Cell proliferation
Li T,Lu H,Zhou L,Jia M,Zhang L,Wu H,Shan L
Fri Apr 01 00:00:00 EDT 2022
LncRNA IPW inhibits growth of ductal carcinoma in situ by downregulating ID2 through miR-29c.
Breast cancer research : BCR
Deshpande RP,Sharma S,Liu Y,Pandey PR,Pei X,Wu K,Wu SY,Tyagi A,Zhao D,Mo YY,Watabe K
AF-100-15 was used in Cell Culture to study which which ductal carcinoma in situ (DCIS) breast lesions can potentially progress to invasive forms and suggest a critical role of the IPW-miR-29c-ID2 axis in DCIS formation.
Tue Jan 25 00:00:00 EST 2022
Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS.
The Journal of cell biology
Kono Y,Adam SA,Sato Y,Reddy KL,Zheng Y,Medalia O,Goldman RD,Kimura H,Shimi T
AF-100-15 was used in Cell Culture to investigate lamins in nuclear envelope.
Mon Dec 05 00:00:00 EST 2022
Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model.
Frontiers in bioengineering and biotechnology
Jones CFE,Di Cio S,Connelly JT,Gautrot JE
AF-100-15 was used in Cell Culture to characterize a chip model of human skin tissue including micro vasculature.
Sat Aug 06 00:00:00 EDT 2022
β-elemene suppresses tumor metabolism and stem cell-like properties of non-small cell lung cancer cells by regulating PI3K/AKT/mTOR signaling.
American journal of cancer research
Cheng G,Li L,Li Q,Lian S,Chu H,Ding Y,Li C,Leng Y
AF-100-15 was used in Cell Culture to show that β-elemene is an effective anticancer adjuvant agent with potential clinical applications.
Sat Jul 16 00:00:00 EDT 2022
Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability.
Translational oncology
Muhammad B,Parks LG,Komurov K,Privette Vinnedge LM
AF-100-15 was used in Cell Culture to report that tumor cells with defect in RNA Polymerase II-mediated transcription elongation (TEdef) overexpress components of protein homeostasis machinery.
Tue Feb 01 00:00:00 EST 2022
Spatial and temporal dynamics of RhoA activities of single breast tumor cells in a 3D environment revealed by a machine learning-assisted FRET technique.
Experimental cell research
Cheung BCH,Hodgson L,Segall JE,Wu M
AF-100-15 was used in Cell Culture to study a machine learning-assisted FRET technique to follow the spatiotemporal dynamics of RhoA activities of single breast tumor cells (MDA-MB-231) migrating in a 3D as well as a 2D environment.
Sat Jan 15 00:00:00 EST 2022
A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation.
Nature communications
Morioka S,Nakanishi H,Yamamoto T,Hasegawa J,Tokuda E,Hikita T,Sakihara T,Kugii Y,Oneyama C,Yamazaki M,Suzuki A,Sasaki J,Sasaki T
Mon Jan 10 00:00:00 EST 2022
RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80.
Cell death & disease
Tian Q,Gao H,Zhou Y,Zhu L,Yang J,Wang B,Liu P,Yang J
Fri Jan 21 00:00:00 EST 2022
Epigenetic and transcriptome responsiveness to ER modulation by tissue selective estrogen complexes in breast epithelial and breast cancer cells.
PloS one
Messier TL,Boyd JR,Gordon JAR,Tye CE,Page NA,Toor RH,Zaidi SK,Komm BS,Frietze S,Stein JL,Lian JB,Stein GS
AF-100-15 was used in Cell Culture to provide direct mechanistic-based evidence that BZA induces epigenetic changes in E2 and EC10 mediated control of ERα regulatory programs to target distinctive proliferation gene pathways that restrain the potential for breast cancer development.
Mon Jul 25 00:00:00 EDT 2022
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids.
Science advances
Li P,Li Y,Wang Y,Liu J,Lavrijsen M,Li Y,Zhang R,Verstegen MMA,Wang Y,Li TC,Ma Z,Kainov DE,Bruno MJ,de Man RA,van der Laan LJW,Peppelenbosch MP,Pan Q
Fri Jan 21 00:00:00 EST 2022
Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors.
Genome medicine
Wang R,Li J,Zhou X,Mao Y,Wang W,Gao S,Wang W,Gao Y,Chen K,Yu S,Wu X,Wen L,Ge H,Fu W,Tang F
AF-100-15 was used in Cell Culture to investigate the genomic and transcriptomic changes in adjacent normie tissues, primary tumors, and metastatic tumors of colorectal cancer patients.
Tue Aug 16 00:00:00 EDT 2022
Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration.
Nature communications
Balzer MS,Doke T,Yang YW,Aldridge DL,Hu H,Mai H,Mukhi D,Ma Z,Shrestha R,Palmer MB,Hunter CA,Susztak K
AF-100-15 was used in Cell Culture to identify a specific maladaptive/profibrotic proximal tubule cluster after long ischemia, which expresses proinflammatory and profibrotic cytokines and myeloid cell chemotactic factors.
Mon Jul 11 00:00:00 EDT 2022
Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration.
Scientific reports
Sahu S,Albaugh ME,Martin BK,Patel NL,Riffle L,Mackem S,Kalen JD,Sharan SK
AF-100-15 was used in Cell Culture to conclude that understanding the function of growth factors in organoids provides novel insights to cell proliferation, stem cell maintenance, tissue repair and organ regeneration in vivo.
Tue May 03 00:00:00 EDT 2022
Generation, Maintenance and HBV Infection of Human Liver Organoids.
Bio-protocol
Romal S,Hossain T,Mahmoudi T
AF-100-15 was used in Cell Culture to propose the use of human liver organoids as a platform for modeling HBV infection and related tumorigenesis.
Sun Mar 20 00:00:00 EDT 2022
Large-Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors.
Advanced healthcare materials
Ho DLL,Lee S,Du J,Weiss JD,Tam T,Sinha S,Klinger D,Devine S,Hamfeldt A,Leng HT,Herrmann JE,He M,Fradkin LG,Tan TK,Standish D,Tomasello P,Traul D,Dianat N,Ladi R,Vicard Q,Katikireddy K,Skylar-Scott MA
AF-100-15 was used in In vitro experiments to demonstrate an optimized suspension culture-to-3D bioprinting pipeline that enables a sustainable approach to billion cell-scale organ engineering.
Thu Dec 01 00:00:00 EST 2022
Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer.
Nature communications
Almanza A,Mnich K,Blomme A,Robinson CM,Rodriguez-Blanco G,Kierszniowska S,McGrath EP,Le Gallo M,Pilalis E,Swinnen JV,Chatziioannou A,Chevet E,Gorman AM,Samali A
AF-100-15 was used in Cell Culture to highlight the importance of IRE1α RIDD activity in reprograming cellular lipid metabolism.
Fri May 06 00:00:00 EDT 2022
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states.
Nature communications
Song H,Weinstein HNW,Allegakoen P,Wadsworth MH,Xie J,Yang H,Castro EA,Lu KL,Stohr BA,Feng FY,Carroll PR,Wang B,Cooperberg MR,Shalek AK,Huang FW
Mon Jan 10 00:00:00 EST 2022
Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity.
iScience
Hangiu O,Compte M,Dinesen A,Navarro R,Tapia-Galisteo A,Mandrup OA,Erce-Llamazares A,Lázaro-Gorines R,Nehme-Álvarez D,Domínguez-Alonso C,Harwood SL,Alfonso C,Blanco B,Rubio-Pérez L,Jiménez-Reinoso A,Díez-Alonso L,Blanco FJ,Sanz L,Howard KA,Álvarez-Vallina L
AF-100-15 was used in Cell Culture to study the cognate target engagement, EGFR-specific costimulatory activity, and FcRn-driven cellular recycling similar to non-fused FcRn high-binding albumin.
Fri Sep 16 00:00:00 EDT 2022
Routine culture and study of adult human brain cells from neurosurgical specimens.
Nature protocols
Park TI,Smyth LCD,Aalderink M,Woolf ZR,Rustenhoven J,Lee K,Jansson D,Smith A,Feng S,Correia J,Heppner P,Schweder P,Mee E,Dragunow M
AF-100-15 was used in Cell Culture to present a protocol to enable the investigation of human brain cells and facilitate translation of neuroscience research to the clinic.
Tue Feb 01 00:00:00 EST 2022
High-throughput formation and image-based analysis of basal-in mammary organoids in 384-well plates.
Scientific reports
Lee S,Chang J,Kang SM,Parigoris E,Lee JH,Huh YS,Takayama S
AF-100-15 was used in Cell Culture to profile early changes in size and circularity.
Mon Jan 10 00:00:00 EST 2022
Repeated intravenous administration of hiPSC-MSCs enhance the efficacy of cell-based therapy in tissue regeneration.
Communications biology
Sun SJ,Li F,Dong M,Liang WH,Lai WH,Ho WI,Wei R,Huang Y,Liao SY,Tse HF
AF-100-15 was used in Sample Preparation (FC/FACS) to demonstrate whether therapeutic efficacy can be improved by combination of repeated intravenous administration and local transplantation of human induced pluripotential stem cell derived MSCs (hiPSC-MSCs).
Thu Aug 25 00:00:00 EDT 2022
MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles.
PloS one
He L,Gao M,Pratt H,Weng Z,Struhl K
AF-100-15 was used in Cell Culture to show that occupancy levels of these factors at these promoter-proximal sites are strongly correlated with the level of paused Pol II and transcriptional activity.
Mon May 02 00:00:00 EDT 2022
Lysine demethylase KDM1A promotes cell growth via FKBP8-BCL2 axis in hepatocellular carcinoma.
The Journal of biological chemistry
Lv S,Zhao X,Zhang E,Yan Y,Ma X,Li N,Zou Q,Sun L,Song T
AF-100-15 was used in Cell Culture to investigate the role of KDM1A in advanced hepatocellular carcinoma.
Thu Sep 01 00:00:00 EDT 2022
Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis.
Journal of neuroinflammation
Figueiredo CA,Steffen J,Morton L,Arumugam S,Liesenfeld O,Deli MA,Kröger A,Schüler T,Dunay IR
AF-100-15 was used in Cell Culture to investigate the blood-brain barrier during Toxoplasma gondii infection.
Thu Jan 13 00:00:00 EST 2022
Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity.
iScience
Li Y,Yang Z,Li X,Yu Y,Li X,Chen P,Li B,Wang X,Ye SD
AF-100-15 was used in Sample Preparation (FC/FACS) to study the downstream mechanism of Prdm14 involved in the maintenance of mouse embryonic stem cell (mESC) pluripotency and the specification of primordial germ cells (PGCs) using high-throughput sequencing, chromatin immunoprecipitation, and luciferase reporter assays. To demonstrate that Prdm14 directly binds to the promoter of Socs3 and represses its transcription to increase the phosphorylation level of Stat3 protein, a critical downstream
Fri Nov 18 00:00:00 EST 2022
Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.
STAR protocols
Martinez-Silgado A,Yousef Yengej FA,Puschhof J,Geurts V,Boot C,Geurts MH,Rookmaaker MB,Verhaar MC,Beumer J,Clevers H
AF-100-15 was used in In vitro experiments to investigate the effects of BMP agonists on differentiation of human small intestinal organoids.
Fri Sep 16 00:00:00 EDT 2022
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium.
Frontiers in immunology
Gopalakrishnan S,Hansen MD,Skovdahl HK,Roseth IA,van Beelen Granlund A,Østvik AE,Bakke I,Sandvik AK,Bruland T
AF-100-15 was used in Cell Culture to identify a regulatory role for IBD-relevant pro-inflammatory signals on MHC-II expression that is influenced by Tofacitinib.
Mon Jun 06 00:00:00 EDT 2022
Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5.
Nature cancer
Sun Y,Yan K,Wang Y,Xu C,Wang D,Zhou W,Guo S,Han Y,Tang L,Shao Y,Shan S,Zhang QC,Tang Y,Zhang L,Xi Q
AF-100-15 was used in Cell Culture to show how BMP signaling impacts diffuse intrinsic pontine glioma (DIPG) and identifies the potent antitumor efficacy of Dacinostat for DIPG.
Thu Sep 01 00:00:00 EDT 2022
Alzheimer's disease like neuropathology in Down syndrome cortical organoids.
Frontiers in cellular neuroscience
Zhao HH,Haddad GG
AF-100-15 was used in Cell Culture to use induced pluripotent stem cell (iPSC) and iPSC-derived 3D cortical organoids to model Alzheimer's disease in Down syndrome and explore the earliest cellular and molecular changes during DS fetal brain development.
Tue Jan 03 00:00:00 EST 2023
Establishment of autaptic culture with human-induced pluripotent stem cell-derived astrocytes.
iScience
Uchino K,Tanaka Y,Kawaguchi S,Kubota K,Watanabe T,Katsurabayashi S,Hirose S,Iwasaki K
AF-100-15 was used in Cell Culture to find a significantly higher Na+ current amplitude, membrane capacitance, and number of synapses, as well as longer dendrites, in HiAACs compared with neuron monocultures and show that the system can facilitate the study of CNS diseases and advance the development of drugs targeting glial cells.
Fri Aug 19 00:00:00 EDT 2022
Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage.
Nature communications
Balasooriya GI,Spector DL
AF-100-15 was used in Cell Culture to elucidate the establishment of monoallelic gene expression in the cardiac lineage, using allele-specific single cell transcriptomic analysis.
Mon Oct 10 00:00:00 EDT 2022
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia.
Life science alliance
Amatngalim GD,Rodenburg LW,Aalbers BL,Raeven HH,Aarts EM,Sarhane D,Spelier S,Lefferts JW,Silva IA,Nijenhuis W,Vrendenbarg S,Kruisselbrink E,Brunsveld JE,van Drunen CM,Michel S,de Winter-de Groot KM,Heijerman HG,Kapitein LC,Amaral MD,van der Ent CK,Beekman JM
AF-100-15 was used in Cell Culture to define organoid culture conditions, with the growth factor/cytokine combination neuregulin-1lt;igt;βlt;/igt; and interleukin-1lt;igt;βlt;/igt;, which enabled consistent detection of CFTR modulator responses in nasal-airway organoid cultures from subjects with cystic fibrosis.
Wed Aug 03 00:00:00 EDT 2022
Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation.
Scientific reports
Wang M,Silva T,Toothaker JM,McCourt BT,Shugrue C,Desir G,Gorelick F,Konnikova L
AF-100-15 was used in Cell Culture to examine the potential role of renalase in placental development.
Wed Mar 23 00:00:00 EDT 2022
MicroRNA-582-5p Contributes to the Maintenance of Neural Stem Cells Through Inhibiting Secretory Protein FAM19A1.
Frontiers in cellular neuroscience
Zhang YF,Li XX,Cao XL,Ji CC,Gao XY,Gao D,Han H,Yu F,Zheng MH
AF-100-15 was used in Cell Culture to study the function and mechanism of miR-582-5p in the maintenance of neural stem cells (NSCs) in vitro and in vivo to uncover a new epigenetic mechanism that regulates the maintenance of NSCs, therefore providing novel targets to amplify NSCs in vitro and to promote neurogenesis in vivo during brain pathology and aging.
Sat Jul 16 00:00:00 EDT 2022
The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens.
NPJ digital medicine
Blasiak A,Truong ATL,Remus A,Hooi L,Seah SGK,Wang P,Chye H,Lim APC,Ng KT,Teo ST,Tan YJ,Allen DM,Chai LYA,Chng WJ,Lin RTP,Lye DCB,Wong JE,Tan GG,Chan CEZ,Chow EK,Ho D
AF-100-15 was used in Cell Culture to utilize the artificial intelligence platform IDentif.AI-x to optimise combinatorial treatment regimens of COVID-19.
Thu Jun 30 00:00:00 EDT 2022
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens.
Cell stem cell
Karvas RM,Khan SA,Verma S,Yin Y,Kulkarni D,Dong C,Park KM,Chew B,Sane E,Fischer LA,Kumar D,Ma L,Boon ACM,Dietmann S,Mysorekar IU,Theunissen TW
AF-100-15 was used in Cell Culture to demonstrate that SC-TOs exhibit selective vulnerability to emerging pathogens (SARS-CoV-2 and Zika virus), which correlates with expression levels of their respective entry factors.
Thu May 05 00:00:00 EDT 2022
Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select.
Nature genetics
Niu Y,Ferreira Azevedo CA,Li X,Kamali E,Haagen Nielsen O,Storgaard Sørensen C,Frödin M
AF-100-15 was used in Tissue/organ culture to present clustered regularly interspaced short palindromic repeat (CRISPR)-SelectTIME, CRISPR-SelectSPACE and CRISPR-SelectSTATE, a set of flexible knock-in assays that introduce a genetic variant in a cell population and track its absolute frequencies relative to an internal, neutral control mutation as a function of time, space or a cell state measurable by flow cytometry.
Thu Dec 01 00:00:00 EST 2022
Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium.
Cell & bioscience
Yuan Y,Chen H,Ou S,Cai B,Zhang R,Qin Y,Pan M,Cao S,Pei D,Hou FF
AF-100-15 was used in In vitro experiments to evaluate the use of reprogramming mitochondria-rich hUCs to generate mitochondria-rich kidney organoids.
Sat Oct 15 00:00:00 EDT 2022
Human Omental Mesothelial Cells Impart an Immunomodulatory Landscape Impeding B- and T-Cell Activation.
International journal of molecular sciences
Gauthier BR,Rubio-Contreras D,Gómez-Rosado JC,Capitán-Morales LC,Hmadcha A,Soria B,Lachaud CC
AF-100-15 was used in Cell Culture to suggest that OMC are potent immunomodulators.
Wed May 25 00:00:00 EDT 2022
Multiple therapeutic effects of human neural stem cells derived from induced pluripotent stem cells in a rat model of post-traumatic syringomyelia.
EBioMedicine
Xu T,Li X,Guo Y,Uhlin E,Holmberg L,Mitra S,Winn D,Falk A,Sundström E
AF-100-15 was used in Cell Culture to study neuroepithelial-like stem cells derived from Good Manufacturing Practice (GMP)-compliant iPSCs.
Tue Mar 01 00:00:00 EST 2022
Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial-Mesenchymal Transition and Responds to Oxidative Stress.
Molecular & cellular proteomics : MCP
Wang Q,Karvelsson ST,Kotronoulas A,Gudjonsson T,Halldorsson S,Rolfsson O
Tue Feb 01 00:00:00 EST 2022
Differentiating functional human islet-like aggregates from pluripotent stem cells.
STAR protocols
Barsby T,Ibrahim H,Lithovius V,Montaser H,Balboa D,Vähäkangas E,Chandra V,Saarimäki-Vire J,Otonkoski T
AF-100-15 was used in In vitro experiments to present here a robust and reliable protocol by which to differentiate pancreatic islet-like aggregates (SC-islets) from human pluripotent stem cells.
Fri Dec 16 00:00:00 EST 2022
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids.
Nature
Han Y,Duan X,Yang L,Nilsson-Payant BE,Wang P,Duan F,Tang X,Yaron TM,Zhang T,Uhl S,Bram Y,Richardson C,Zhu J,Zhao Z,Redmond D,Houghton S,Nguyen DT,Xu D,Wang X,Jessurun J,Borczuk A,Huang Y,Johnson JL,Liu Y,Xiang J,Wang H,Cantley LC,tenOever BR,Ho DD,Pan FC,Evans T,Chen HJ,Schwartz RE,Chen S
Fri Jan 01 00:00:00 EST 2021
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.
Nature
Casanova-Acebes M,Dalla E,Leader AM,LeBerichel J,Nikolic J,Morales BM,Brown M,Chang C,Troncoso L,Chen ST,Sastre-Perona A,Park MD,Tabachnikova A,Dhainaut M,Hamon P,Maier B,Sawai CM,Agulló-Pascual E,Schober M,Brown BD,Reizis B,Marron T,Kenigsberg E,Moussion C,Benaroch P,Aguirre-Ghiso JA,Merad M
Thu Jul 01 00:00:00 EDT 2021
Functional interrogation of DNA damage response variants with base editing screens.
Cell
Cuella-Martin R,Hayward SB,Fan X,Chen X,Huang JW,Taglialatela A,Leuzzi G,Zhao J,Rabadan R,Lu C,Shen Y,Ciccia A
Thu Feb 18 00:00:00 EST 2021
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Cell
Cui C,Chakraborty K,Tang XA,Zhou G,Schoenfelt KQ,Becker KM,Hoffman A,Chang YF,Blank A,Reardon CA,Kenny HA,Vaisar T,Lengyel E,Greene G,Becker L
Thu Jun 10 00:00:00 EDT 2021
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Cell
Bowles KR,Silva MC,Whitney K,Bertucci T,Berlind JE,Lai JD,Garza JC,Boles NC,Mahali S,Strang KH,Marsh JA,Chen C,Pugh DA,Liu Y,Gordon RE,Goderie SK,Chowdhury R,Lotz S,Lane K,Crary JF,Haggarty SJ,Karch CM,Ichida JK,Goate AM,Temple S
Thu Aug 19 00:00:00 EDT 2021
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Cell
Koikawa K,Kibe S,Suizu F,Sekino N,Kim N,Manz TD,Pinch BJ,Akshinthala D,Verma A,Gaglia G,Nezu Y,Ke S,Qiu C,Ohuchida K,Oda Y,Lee TH,Wegiel B,Clohessy JG,London N,Santagata S,Wulf GM,Hidalgo M,Muthuswamy SK,Nakamura M,Gray NS,Zhou XZ,Lu KP
Thu Sep 02 00:00:00 EDT 2021
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion.
Cell
Nader GPF,Agüera-Gonzalez S,Routet F,Gratia M,Maurin M,Cancila V,Cadart C,Palamidessi A,Ramos RN,San Roman M,Gentili M,Yamada A,Williart A,Lodillinsky C,Lagoutte E,Villard C,Viovy JL,Tripodo C,Galon J,Scita G,Manel N,Chavrier P,Piel M
Thu Sep 30 00:00:00 EDT 2021
Automated segmentation and tracking of mitochondria in live-cell time-lapse images.
Nature methods
Lefebvre AEYT,Ma D,Kessenbrock K,Lawson DA,Digman MA
Wed Sep 01 00:00:00 EDT 2021
RAB31 marks and controls an ESCRT-independent exosome pathway.
Cell research
Wei D,Zhan W,Gao Y,Huang L,Gong R,Wang W,Zhang R,Wu Y,Gao S,Kang T
Mon Feb 01 00:00:00 EST 2021
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling.
Cell research
Zhang XN,Yang KD,Chen C,He ZC,Wang QH,Feng H,Lv SQ,Wang Y,Mao M,Liu Q,Tan YY,Wang WY,Li TR,Che LR,Qin ZY,Wu LX,Luo M,Luo CH,Liu YQ,Yin W,Wang C,Guo HT,Li QR,Wang B,Chen W,Wang S,Shi Y,Bian XW,Ping YF
AF-100-15 was used in Cell Culture to reveal the role of pericytes as an extrinsic stimulator potentiating DDR signaling in GBM cells.
Fri Oct 01 00:00:00 EDT 2021
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling.
Cell research
Zhang XN,Yang KD,Chen C,He ZC,Wang QH,Feng H,Lv SQ,Wang Y,Mao M,Liu Q,Tan YY,Wang WY,Li TR,Che LR,Qin ZY,Wu LX,Luo M,Luo CH,Liu YQ,Yin W,Wang C,Guo HT,Li QR,Wang B,Chen W,Wang S,Shi Y,Bian XW,Ping YF
AF-100-15 was used in Cell Culture to reveal the role of pericytes as an extrinsic stimulator potentiating DDR signaling in GBM cells.
Fri Oct 01 00:00:00 EDT 2021
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns.
Nature genetics
Bollen Y,Stelloo E,van Leenen P,van den Bos M,Ponsioen B,Lu B,van Roosmalen MJ,Bolhaqueiro ACF,Kimberley C,Mossner M,Cross WCH,Besselink NJM,van der Roest B,Boymans S,Oost KC,de Vries SG,Rehmann H,Cuppen E,Lens SMA,Kops GJPL,Kloosterman WP,Terstappen LWMM,Barnes CP,Sottoriva A,Graham TA,Snippert HJG
Sun Aug 01 00:00:00 EDT 2021
ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis.
Nature genetics
Granja JM,Corces MR,Pierce SE,Bagdatli ST,Choudhry H,Chang HY,Greenleaf WJ
AF-100-15 was used in Cell Culture to present a software suite for single-cell analysis of regulatory chromatin in R (ArchR; https://www.archrproject.com/ ) that enables fast and comprehensive analysis of single-cell chromatin accessibility data.
Mon Mar 01 00:00:00 EST 2021
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Cancer cell
Hara T,Chanoch-Myers R,Mathewson ND,Myskiw C,Atta L,Bussema L,Eichhorn SW,Greenwald AC,Kinker GS,Rodman C,Gonzalez Castro LN,Wakimoto H,Rozenblatt-Rosen O,Zhuang X,Fan J,Hunter T,Verma IM,Wucherpfennig KW,Regev A,Suvà ML,Tirosh I
Mon Jun 14 00:00:00 EDT 2021
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.
Cancer cell
Haag D,Mack N,Benites Goncalves da Silva P,Statz B,Clark J,Tanabe K,Sharma T,Jäger N,Jones DTW,Kawauchi D,Wernig M,Pfister SM
Mon Mar 08 00:00:00 EST 2021
Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription.
Cancer cell
Zhu Y,Gujar AD,Wong CH,Tjong H,Ngan CY,Gong L,Chen YA,Kim H,Liu J,Li M,Mil-Homens A,Maurya R,Kuhlberg C,Sun F,Yi E,deCarvalho AC,Ruan Y,Verhaak RGW,Wei CL
Mon May 10 00:00:00 EDT 2021
Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3.
Signal transduction and targeted therapy
Sun H,Wang C,Hu B,Gao X,Zou T,Luo Q,Chen M,Fu Y,Sheng Y,Zhang K,Zheng Y,Ren X,Yan S,Geng Y,Yang L,Dong Q,Qin L
Wed May 26 00:00:00 EDT 2021
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
AF-100-15 was used in Tissue/organ culture to report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas.
Thu Jun 03 00:00:00 EDT 2021
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
AF-100-15 was used in Tissue/organ culture to report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas.
Thu Jun 03 00:00:00 EDT 2021
Principles of signaling pathway modulation for enhancing human naive pluripotency induction.
Cell stem cell
Bayerl J,Ayyash M,Shani T,Manor YS,Gafni O,Massarwa R,Kalma Y,Aguilera-Castrejon A,Zerbib M,Amir H,Sheban D,Geula S,Mor N,Weinberger L,Naveh Tassa S,Krupalnik V,Oldak B,Livnat N,Tarazi S,Tawil S,Wildschutz E,Ashouokhi S,Lasman L,Rotter V,Hanna S,Ben-Yosef D,Novershtern N,Viukov S,Hanna JH
Thu Sep 02 00:00:00 EDT 2021
Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy.
Advanced functional materials
Karlsson J,Tzeng SY,Hemmati S,Luly KM,Choi O,Rui Y,Wilson DR,Kozielski KL,Quiñones-Hinojosa A,Green JJ
Thu Apr 22 00:00:00 EDT 2021
Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis.
The Journal of clinical investigation
Doke T,Huang S,Qiu C,Liu H,Guan Y,Hu H,Ma Z,Wu J,Miao Z,Sheng X,Zhou J,Cao A,Li J,Kaufman L,Hung A,Brown CD,Pestell R,Susztak K
Mon May 17 00:00:00 EDT 2021
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma.
The Journal of clinical investigation
Osuka S,Zhu D,Zhang Z,Li C,Stackhouse CT,Sampetrean O,Olson JJ,Gillespie GY,Saya H,Willey CD,Van Meir EG
Mon Mar 15 00:00:00 EDT 2021
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma.
The Journal of clinical investigation
Osuka S,Zhu D,Zhang Z,Li C,Stackhouse CT,Sampetrean O,Olson JJ,Gillespie GY,Saya H,Willey CD,Van Meir EG
Mon Mar 15 00:00:00 EDT 2021
Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.
The Journal of clinical investigation
Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T
AF-100-15 was used in Cell Culture to conclude that Samd9/9L is a downstream regulator of IFN that controls receptor metabolism, with constitutive activation leading to multiorgan dysfunction.
Mon Feb 15 00:00:00 EST 2021
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
Molecular cell
Durgan J,Lystad AH,Sloan K,Carlsson SR,Wilson MI,Marcassa E,Ulferts R,Webster J,Lopez-Clavijo AF,Wakelam MJ,Beale R,Simonsen A,Oxley D,Florey O
Thu May 06 00:00:00 EDT 2021
Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding.
Neuron
Han S,Okawa S,Wilkinson GA,Ghazale H,Adnani L,Dixit R,Tavares L,Faisal I,Brooks MJ,Cortay V,Zinyk D,Sivitilli A,Li S,Malik F,Ilnytskyy Y,Angarica VE,Gao J,Chinchalongporn V,Oproescu AM,Vasan L,Touahri Y,David LA,Raharjo E,Kim JW,Wu W,Rahmani W,Chan JA,Kovalchuk I,Attisano L,Kurrasch D,Dehay C,Swaroop A,Castro DS,Biernaskie J,Del Sol A,Schuurmans C
Wed Sep 15 00:00:00 EDT 2021
Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids.
EMBO molecular medicine
Trujillo CA,Adams JW,Negraes PD,Carromeu C,Tejwani L,Acab A,Tsuda B,Thomas CA,Sodhi N,Fichter KM,Romero S,Zanella F,Sejnowski TJ,Ulrich H,Muotri AR
Mon Jan 11 00:00:00 EST 2021
Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
The EMBO journal
Lindhout FW,Portegies S,Kooistra R,Herstel LJ,Stucchi R,Hummel JJA,Scheefhals N,Katrukha EA,Altelaar M,MacGillavry HD,Wierenga CJ,Hoogenraad CC
Mon May 17 00:00:00 EDT 2021
WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling.
Molecular psychiatry
Wang M,Tang C,Xing R,Liu X,Han X,Liu Y,Wang L,Yang C,Guo W
Mon Feb 01 00:00:00 EST 2021
Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Molecular psychiatry
Griesi-Oliveira K,Fogo MS,Pinto BGG,Alves AY,Suzuki AM,Morales AG,Ezquina S,Sosa OJ,Sutton GJ,Sunaga-Franze DY,Bueno AP,Seabra G,Sardinha L,Costa SS,Rosenberg C,Zachi EC,Sertie AL,Martins-de-Souza D,Reis EM,Voineagu I,Passos-Bueno MR
Sat May 01 00:00:00 EDT 2021
Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites.
Developmental cell
Wu H,Voeltz GK
AF-100-15 was used in Sample Preparation (Western Blotting) to find that a member of the reticulon protein family, Reticulon-3L (Rtn3L), enriches at ER-endosome MCSs as endosomes mature.
Mon Jan 11 00:00:00 EST 2021
Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival.
Developmental cell
Gagliardi PA,Dobrzyński M,Jacques MA,Dessauges C,Ender P,Blum Y,Hughes RM,Cohen AR,Pertz O
Mon Jun 21 00:00:00 EDT 2021
Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease.
Molecular therapy : the journal of the American Society of Gene Therapy
Heller GJ,Marshall MS,Issa Y,Marshall JN,Nguyen D,Rue E,Pathmasiri KC,Domowicz MS,van Breemen RB,Tai LM,Cologna SM,Crocker SJ,Givogri MI,Sands MS,Bongarzone ER
Wed May 05 00:00:00 EDT 2021
Early-life midazolam exposure persistently changes chromatin accessibility to impair adult hippocampal neurogenesis and cognition.
Proceedings of the National Academy of Sciences of the United States of America
Doi H,Matsuda T,Sakai A,Matsubara S,Hoka S,Yamaura K,Nakashima K
Tue Sep 21 00:00:00 EDT 2021
ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts.
Proceedings of the National Academy of Sciences of the United States of America
Li Q,Meissner TB,Wang F,Du Z,Ma S,Kshirsagar S,Tilburgs T,Buenrostro JD,Uesugi M,Strominger JL
Tue Mar 02 00:00:00 EST 2021
UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.
Proceedings of the National Academy of Sciences of the United States of America
Wolfe AL,Zhou Q,Toska E,Galeas J,Ku AA,Koche RP,Bandyopadhyay S,Scaltriti M,Lebrilla CB,McCormick F,Kim SE
Tue Aug 03 00:00:00 EDT 2021
The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer.
Cell death and differentiation
Bassi C,Fortin J,Snow BE,Wakeham A,Ho J,Haight J,You-Ten A,Cianci E,Buckler L,Gorrini C,Stambolic V,Mak TW
Mon Nov 01 00:00:00 EDT 2021
BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer.
Cell death and differentiation
Ramesh P,Lannagan TRM,Jackstadt R,Atencia Taboada L,Lansu N,Wirapati P,van Hooff SR,Dekker D,Pritchard J,Kirov AB,van Neerven SM,Tejpar S,Kops GJPL,Sansom OJ,Medema JP
Wed Dec 01 00:00:00 EST 2021
TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression.
Cell systems
Kälin RE,Cai L,Li Y,Zhao D,Zhang H,Cheng J,Zhang W,Wu Y,Eisenhut K,Janssen P,Schmitt L,Enard W,Michels F,Flüh C,Hou M,Kirchleitner SV,Siller S,Schiemann M,Andrä I,Montanez E,Giachino C,Taylor V,Synowitz M,Tonn JC,von Baumgarten L,Schulz C,Hellmann I,Glass R
Wed Mar 17 00:00:00 EDT 2021
TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression.
Cell systems
Kälin RE,Cai L,Li Y,Zhao D,Zhang H,Cheng J,Zhang W,Wu Y,Eisenhut K,Janssen P,Schmitt L,Enard W,Michels F,Flüh C,Hou M,Kirchleitner SV,Siller S,Schiemann M,Andrä I,Montanez E,Giachino C,Taylor V,Synowitz M,Tonn JC,von Baumgarten L,Schulz C,Hellmann I,Glass R
Wed Mar 17 00:00:00 EDT 2021
The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation.
PLoS biology
Levandowski CB,Jones T,Gruca M,Ramamoorthy S,Dowell RD,Taatjes DJ
AF-100-15 was used in Cell Culture to study how the Δ40p53 isoform alters wild-type p53 (WTp53) function to establish that Δ40p53 tempers WTp53 function to enable compensatory responses by other stimulus-specific TFs.
Sun Aug 01 00:00:00 EDT 2021
Aspirin enhances the therapeutic efficacy of cisplatin in oesophageal squamous cell carcinoma by inhibition of putative cancer stem cells.
British journal of cancer
Zou Z,Zheng W,Fan H,Deng G,Lu SH,Jiang W,Yu X
Wed Sep 01 00:00:00 EDT 2021
Modelling of primary ciliary dyskinesia using patient-derived airway organoids.
EMBO reports
van der Vaart J,Böttinger L,Geurts MH,van de Wetering WJ,Knoops K,Sachs N,Begthel H,Korving J,Lopez-Iglesias C,Peters PJ,Eitan K,Gileles-Hillel A,Clevers H
Mon Dec 06 00:00:00 EST 2021
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.
Oncogene
Lindzen M,Ghosh S,Noronha A,Drago D,Nataraj NB,Leitner O,Carvalho S,Zmora E,Sapoznik S,Shany KB,Levanon K,Aderka D,Ramírez BS,Dahlhoff M,McNeish I,Yarden Y
Sat May 01 00:00:00 EDT 2021
The biological process of lysine-tRNA charging is therapeutically targetable in liver cancer.
Liver international : official journal of the International Association for the Study of the Liver
Zhang R,Noordam L,Ou X,Ma B,Li Y,Das P,Shi S,Liu J,Wang L,Li P,Verstegen MMA,Reddy DS,van der Laan LJW,Peppelenbosch MP,Kwekkeboom J,Smits R,Pan Q
Fri Jan 01 00:00:00 EST 2021
IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity.
Mucosal immunology
Gaudino SJ,Beaupre M,Lin X,Joshi P,Rathi S,McLaughlin PA,Kempen C,Mehta N,Eskiocak O,Yueh B,Blumberg RS,van der Velden AWM,Shroyer KR,Bialkowska AB,Beyaz S,Kumar P
Mon Mar 01 00:00:00 EST 2021
The nature of cell division forces in epithelial monolayers.
The Journal of cell biology
Gupta VK,Nam S,Yim D,Camuglia J,Martin JL,Sanders EN,O'Brien LE,Martin AC,Kim T,Chaudhuri O
AF-100-15 was used in Cell Culture to study the two distinct stages of division: elongation, and postdivision spreading.
Mon Aug 02 00:00:00 EDT 2021
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.
Stem cells translational medicine
Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H
Tue Jun 01 00:00:00 EDT 2021
High-throughput screening in postimplantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming.
Stem cells translational medicine
Gao Q,Zhang W,Zhao Y,Tian Y,Wang Y,Zhang J,Geng M,Xu M,Yao C,Wang H,Li L,Liu Y,Shuai L
Sat May 01 00:00:00 EDT 2021
Uncoupling protein 2-mediated metabolic adaptations define cardiac cell function in the heart during transition from young to old age.
Stem cells translational medicine
Kurian J,Yuko AE,Kasatkin N,Rigaud VOC,Busch K,Harlamova D,Wagner M,Recchia FA,Wang H,Mohsin S,Houser SR,Khan M
Fri Jan 01 00:00:00 EST 2021
A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury.
Stem cells translational medicine
Kamata Y,Isoda M,Sanosaka T,Shibata R,Ito S,Okubo T,Shinozaki M,Inoue M,Koya I,Shibata S,Shindo T,Matsumoto M,Nakamura M,Okano H,Nagoshi N,Kohyama J
Mon Mar 01 00:00:00 EST 2021
Exosomal lncRNA PVT1/VEGFA Axis Promotes Colon Cancer Metastasis and Stemness by Downregulation of Tumor Suppressor miR-152-3p.
Oxidative medicine and cellular longevity
Lai SW,Chen MY,Bamodu OA,Hsieh MS,Huang TY,Yeh CT,Lee WH,Cherng YG
Fri Jan 28 00:00:00 EST 2022
BAPTA, a calcium chelator, neuroprotects injured neurons in vitro and promotes motor recovery after spinal cord transection in vivo.
CNS neuroscience & therapeutics
Kang KR,Kim J,Ryu B,Lee SG,Oh MS,Baek J,Ren X,Canavero S,Kim CY,Chung HM
Sun Aug 01 00:00:00 EDT 2021
Characterization of primary models of human trophoblast.
Development (Cambridge, England)
Sheridan MA,Zhao X,Fernando RC,Gardner L,Perez-Garcia V,Li Q,Marsh SGE,Hamilton R,Moffett A,Turco MY
AF-100-15 was used in Cell Culture to show that our results can be used to select the most suitable model for the study of trophoblast development, function and pathology.
Mon Nov 01 00:00:00 EDT 2021
APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ramakrishna S,Jhaveri V,Konings SC,Nawalpuri B,Chakraborty S,Holst B,Schmid B,Gouras GK,Freude KK,Muddashetty RS
AF-100-15 was used in Cell Culture to show that the defective protein synthesis mediated by APOE4 is closely linked to the perturbation of calcium homeostasis caused by APOE4 in neurons.
Wed Oct 20 00:00:00 EDT 2021
Bruton's tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma.
Oncogenesis
Yeh CT,Chen TT,Satriyo PB,Wang CH,Wu ATH,Chao TY,Lee KY,Hsiao M,Wang LS,Kuo KT
Tue Jul 27 00:00:00 EDT 2021
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
AF-100-15 was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.
Mon Feb 01 00:00:00 EST 2021
Selective sodium iodide symporter (NIS) genetherapy of glioblastoma mediatedby EGFR-targeted lipopolyplexes.
Molecular therapy oncolytics
Spellerberg R,Benli-Hoppe T,Kitzberger C,Berger S,Schmohl KA,Schwenk N,Yen HY,Zach C,Schilling F,Weber WA,Kälin RE,Glass R,Nelson PJ,Wagner E,Spitzweg C
Fri Dec 17 00:00:00 EST 2021
Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma.
Molecular therapy oncolytics
Wirsching HG,Silginer M,Ventura E,Macnair W,Burghardt I,Claassen M,Gatti S,Wichmann J,Riemer C,Schneider H,Weller M
Fri Mar 26 00:00:00 EDT 2021
HDAC1 Regulates Neuronal Differentiation.
Frontiers in molecular neuroscience
Nieto-Estevez V,Changarathil G,Adeyeye AO,Coppin MO,Kassim RS,Zhu J,Hsieh J
AF-100-15 was used in Cell Culture to decipher the role of individual histone deacetylases in adult hippocampal neurogenesis.
Tue Feb 01 00:00:00 EST 2022
Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration.
Frontiers in cell and developmental biology
Li J,Qiu C,Wei Y,Yuan W,Liu J,Cui W,Zhou J,Qiu C,Guo L,Huang L,Ge Z,Yu L
AF-100-15 was used in Cell Culture to propose that subretinal transplantation of hAESCs-RPE could be an optional therapeutic strategy for retinal degeneration diseases.
Sat Oct 16 00:00:00 EDT 2021
Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction.
Frontiers in cell and developmental biology
Zhang H,Zhao C,Jiang G,Hu B,Zheng H,Hong Y,Cui Z,Shi L,Li X,Lin F,Ding Y,Wei L,Li M,Liang X,Zhang Y
AF-100-15 was used in Cell Culture to study whether the Apelin ligand regulates mesenchymal stem cell (MSC) senescence and whether its overexpression could rejuvenate aged MSCs (AMSCs) to improve cardiac protection following infarction in mice.
Sat Mar 20 00:00:00 EDT 2021
Urine stem cells are equipped to provide B cell survival signals.
Stem cells (Dayton, Ohio)
Zidan AA,Perkins GB,Al-Hawwas M,Elhossiny A,Yang J,Bobrovskaya L,Mourad GM,Zhou XF,Hurtado PR
Tue Jun 01 00:00:00 EDT 2021
Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kim SE,Zhang J,Jiang E,Overholtzer M
Fri Oct 01 00:00:00 EDT 2021
NEK7 Promotes Pancreatic Cancer Progression And Its Expression Is Correlated With Poor Prognosis.
Frontiers in oncology
Yan Z,Qu J,Li Z,Yi J,Su Y,Lin Q,Yu G,Lin Z,Yin W,Lu F,Liu J
AF-100-15 was used in Cell Culture to indicate that NEK7 promotes pancreatic cancer progression and it may be a potential marker for PDAC prognosis.
Sat Jul 24 00:00:00 EDT 2021
Wnt/β-Catenin Inhibition Disrupts Carboplatin Resistance in Isogenic Models of Triple-Negative Breast Cancer.
Frontiers in oncology
Abreu de Oliveira WA,Moens S,El Laithy Y,van der Veer BK,Athanasouli P,Cortesi EE,Baietti MF,Koh KP,Ventura JJ,Amant F,Annibali D,Lluis F
AF-100-15 was used in Cell Culture to provide evidence for a prominent role of Wnt signaling in mediating resistance to carboplatin, and we establish that combinatorial targeting of Wnt signaling overcomes carboplatin resistance enhancing chemotherapeutic drug efficacy.
Tue Aug 10 00:00:00 EDT 2021
The stabilization of yes-associated protein by TGFβ-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells.
Journal of cellular and molecular medicine
Wang G,Sun Q,Zhu H,Bi Y,Zhu H,Xu A
Thu Jul 01 00:00:00 EDT 2021
Dendritic cells loaded with exosomes derived from cancer stem cell-enriched spheroids as a potential immunotherapeutic option.
Journal of cellular and molecular medicine
Naseri M,Zöller M,Hadjati J,Ghods R,Ranaei Pirmardan E,Kiani J,Eini L,Bozorgmehr M,Madjd Z
Thu Apr 01 00:00:00 EDT 2021
AS602801 sensitizes glioma cells to temozolomide and vincristine by blocking gap junction communication between glioma cells and astrocytes.
Journal of cellular and molecular medicine
Zhang S,Gong Y,Wang H,Li Z,Huang Y,Fu X,Xiang P,Fan T
Thu Apr 01 00:00:00 EDT 2021
SOX12 Promotes Stem Cell-Like Phenotypes and Osteosarcoma Tumor Growth by Upregulating JAGGED1.
Stem cells international
Zhang W,Yu F,Weng J,Zheng Y,Lin J,Qi T,Wei Y,Wang D,Zeng H
Wed Nov 03 00:00:00 EDT 2021
Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.
Journal of neuro-oncology
Crotty EE,Smith SMC,Brasel K,Pakiam F,Girard EJ,Connor YD,Zindy F,Mhyre AJ,Roussel MF,Olson JM
AF-100-15 was used in Cell Culture to investigate the role of tumour-associated macrophage infiltration in cancer progression.
Tue Jun 01 00:00:00 EDT 2021
Sirtuin 3 inhibits nuclear factor-κB signaling activated by a fatty acid challenge in bovine mammary epithelial cells.
Journal of dairy science
Liu L,Lu H,Loor JJ,Aboragah A,Du X,He J,Peng T,Su J,Wang Z,Liu G,Li X
AF-100-15 was used in Sample Preparation to study whether increases in circulating nonesterified fatty acids (NEFA) concentrations, as observed in the transition period, provokes inflammatory responses that can be reversed via activation of sirtuin 3 (SIRT3) to suggest a promising role of SIRT3 as a target for helping alleviate localized inflammation of the mammary gland resulting from exposure to high concentrations of NEFA.
Wed Dec 01 00:00:00 EST 2021
Repositioning of duloxetine to target pancreatic stellate cells.
Oncology letters
Sagara A,Nakata K,Matsumoto S,Guan W,Shinkawa T,Iwamoto C,Ikenaga N,Ohuchida K,Nakamura M
AF-100-15 was used in Tissue/organ culture to suggest that duloxetine may be a potential drug for suppressing PSC activation and pancreatic cancer growth.
Fri Oct 01 00:00:00 EDT 2021
Three Dimensional Cell Culturing for Modeling Adrenal and Pituitary Tumors.
Pathology oncology research : POR
Krokker L,Szabó B,Németh K,Tóháti R,Sarkadi B,Mészáros K,Patócs A,Butz H
AF-100-15 was used in Cell Culture to help understanding the pathogenesis of endocrine tumors and revealing potential biomarkers and therapeutic targets.
Mon Jan 03 00:00:00 EST 2022
Three Dimensional Cell Culturing for Modeling Adrenal and Pituitary Tumors.
Pathology oncology research : POR
Krokker L,Szabó B,Németh K,Tóháti R,Sarkadi B,Mészáros K,Patócs A,Butz H
AF-100-15 was used in Cell Culture to help understanding the pathogenesis of endocrine tumors and revealing potential biomarkers and therapeutic targets.
Mon Jan 03 00:00:00 EST 2022
The white matter is a pro-differentiative niche for glioblastoma.
Nature communications
Brooks LJ,Clements MP,Burden JJ,Kocher D,Richards L,Devesa SC,Zakka L,Woodberry M,Ellis M,Jaunmuktane Z,Brandner S,Morrison G,Pollard SM,Dirks PB,Marguerat S,Parrinello S
Mon Apr 12 00:00:00 EDT 2021
Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation.
Cell death & disease
Juric V,Hudson L,Fay J,Richards CE,Jahns H,Verreault M,Bielle F,Idbaih A,Lamfers MLM,Hopkins AM,Rehm M,Murphy BM
Tue Aug 03 00:00:00 EDT 2021
Re-expression of REG family and DUOXs genes in CRC organoids by co-culturing with CAFs.
Scientific reports
Naruse M,Ochiai M,Sekine S,Taniguchi H,Yoshida T,Ichikawa H,Sakamoto H,Kubo T,Matsumoto K,Ochiai A,Imai T
Fri Jan 22 00:00:00 EST 2021
Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy.
Nature communications
Krieger TG,Le Blanc S,Jabs J,Ten FW,Ishaque N,Jechow K,Debnath O,Leonhardt CS,Giri A,Eils R,Strobel O,Conrad C
Tue Oct 05 00:00:00 EDT 2021
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.
Cell reports
Schild T,McReynolds MR,Shea C,Low V,Schaffer BE,Asara JM,Piskounova E,Dephoure N,Rabinowitz JD,Gomes AP,Blenis J
Tue Jun 15 00:00:00 EDT 2021
Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2.
Cells
Park JH,Choi Y,Lim CW,Park JM,Yu SH,Kim Y,Han HJ,Kim CH,Song YS,Kim C,Yu SR,Oh EY,Lee SM,Moon J
Sun Sep 12 00:00:00 EDT 2021
PRMT5 inhibition disrupts splicing and stemness in glioblastoma.
Nature communications
Sachamitr P,Ho JC,Ciamponi FE,Ba-Alawi W,Coutinho FJ,Guilhamon P,Kushida MM,Cavalli FMG,Lee L,Rastegar N,Vu V,Sánchez-Osuna M,Coulombe-Huntington J,Kanshin E,Whetstone H,Durand M,Thibault P,Hart K,Mangos M,Veyhl J,Chen W,Tran N,Duong BC,Aman AM,Che X,Lan X,Whitley O,Zaslaver O,Barsyte-Lovejoy D,Richards LM,Restall I,Caudy A,Röst HL,Bonday ZQ,Bernstein M,Das S,Cusimano MD,Spears J,Bader GD,Pugh TJ,Tyers M,Lupien M,Haibe-Kains B,Artee Luchman H,Weiss S,Massirer KB,Prinos P,Arrowsmith CH,Dirks PB
Fri Feb 12 00:00:00 EST 2021
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ.
Nature communications
Della Chiara G,Gervasoni F,Fakiola M,Godano C,D'Oria C,Azzolin L,Bonnal RJP,Moreni G,Drufuca L,Rossetti G,Ranzani V,Bason R,De Simone M,Panariello F,Ferrari I,Fabbris T,Zanconato F,Forcato M,Romano O,Caroli J,Gruarin P,Sarnicola ML,Cordenonsi M,Bardelli A,Zucchini N,Ceretti AP,Mariani NM,Cassingena A,Sartore-Bianchi A,Testa G,Gianotti L,Opocher E,Pisati F,Tripodo C,Macino G,Siena S,Bicciato S,Piccolo S,Pagani M
Tue Apr 20 00:00:00 EDT 2021
Integrated Metabolomics and Transcriptomics Analysis of Monolayer and Neurospheres from Established Glioblastoma Cell Lines.
Cancers
Peixoto J,Janaki-Raman S,Schlicker L,Schmitz W,Walz S,Winkelkotte AM,Herold-Mende C,Soares P,Schulze A,Lima J
AF-100-15 was used in Cell Culture to investigate the transcriptome of cancer-like stem cells in glioblastoma.
Tue Mar 16 00:00:00 EDT 2021
Generation of mouse hippocampal neural precursor cell lines with CRISPR/Cas9-mediated gene knockouts.
STAR protocols
Zocher S,Kempermann G
AF-100-15 was used in Cell Culture to outline CRISPR/Cas9 manipulation of knockout in mouse hippocampal neural precursor lines.
Fri Jun 18 00:00:00 EDT 2021
Ultrastructural analysis of breast cancer patient-derived organoids.
Cancer cell international
Signati L,Allevi R,Piccotti F,Albasini S,Villani L,Sevieri M,Bonizzi A,Corsi F,Mazzucchelli S
AF-100-15 was used in Cell Culture to demonstrate the suitability of breast cancer PDO as 3-dimensional model of mammary tissue.
Tue Aug 10 00:00:00 EDT 2021
A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation.
iScience
Kang W,Ferruzzi J,Spatarelu CP,Han YL,Sharma Y,Koehler SA,Mitchel JA,Khan A,Butler JP,Roblyer D,Zaman MH,Park JA,Guo M,Chen Z,Pegoraro AF,Fredberg JJ
Fri Nov 19 00:00:00 EST 2021
PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates.
Communications biology
Shimizu N,Asatsuma-Okumura T,Yamamoto J,Yamaguchi Y,Handa H,Ito T
Thu Nov 11 00:00:00 EST 2021
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
Cell reports
Martirosian V,Deshpande K,Zhou H,Shen K,Smith K,Northcott P,Lin M,Stepanosyan V,Das D,Remsik J,Isakov D,Boire A,De Feyter H,Hurth K,Li S,Wiemels J,Nakamura B,Shao L,Danilov C,Chen T,Neman J
Tue Jun 29 00:00:00 EDT 2021
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection.
Cell reports
Duan X,Tang X,Nair MS,Zhang T,Qiu Y,Zhang W,Wang P,Huang Y,Xiang J,Wang H,Schwartz RE,Ho DD,Evans T,Chen S
Tue Nov 09 00:00:00 EST 2021
Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation.
Nature communications
Ramosaj M,Madsen S,Maillard V,Scandella V,Sudria-Lopez D,Yuizumi N,Telley L,Knobloch M
Tue Dec 21 00:00:00 EST 2021
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.
Nature communications
Bassil R,Shields K,Granger K,Zein I,Ng S,Chih B
Wed Sep 01 00:00:00 EDT 2021
Inhibiting an RBM39/MLL1 epigenomic regulatory complex with dominant-negative peptides disrupts cancer cell transcription and proliferation.
Cell reports
Puvvula PK,Yu Y,Sullivan KR,Eyob H,Rosenberg J,Welm A,Huff C,Moon AM
Tue Jun 01 00:00:00 EDT 2021
Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells.
Stem cell reports
Watson AES,de Almeida MMA,Dittmann NL,Li Y,Torabi P,Footz T,Vetere G,Galleguillos D,Sipione S,Cardona AE,Voronova A
Tue Aug 10 00:00:00 EDT 2021
Recursive feedback between matrix dissipation and chemo-mechanical signaling drives oscillatory growth of cancer cell invadopodia.
Cell reports
Gong Z,Wisdom KM,McEvoy E,Chang J,Adebowale K,Price CC,Chaudhuri O,Shenoy VB
Tue Apr 27 00:00:00 EDT 2021
Intestinal organoid cocultures with microbes.
Nature protocols
Puschhof J,Pleguezuelos-Manzano C,Martinez-Silgado A,Akkerman N,Saftien A,Boot C,de Waal A,Beumer J,Dutta D,Heo I,Clevers H
AF-100-15 was used in Cell Culture to provide detailed protocols for characterizing the coculture with regard to bacterial and organoid cell viability and growth kinetics.
Fri Oct 01 00:00:00 EDT 2021
Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD.
Brain sciences
Ramic M,Andrade NS,Rybin MJ,Esanov R,Wahlestedt C,Benatar M,Zeier Z
AF-100-15 was used in Cell Culture to characterize the nucleocytoplasmic transport and increased DNA damage disturbances and determine the relative contribution of different dipeptide repeat proteins (DPRs) needed to facilitate the development of novel therapeutics for C9ALS/ frontotemporal dementia (FTD).
Sat Nov 20 00:00:00 EST 2021
Expression and Function of C1orf132 Long-Noncoding RNA in Breast Cancer Cell Lines and Tissues.
International journal of molecular sciences
Shafaroudi AM,Sharifi-Zarchi A,Rahmani S,Nafissi N,Mowla SJ,Lauria A,Oliviero S,Matin MM
AF-100-15 was used in Cell Culture to investigate microRNAs from C1orf132 in breast cancer progression.
Wed Jun 23 00:00:00 EDT 2021
Selective and noncovalent targeting of RAS mutants for inhibition and degradation.
Nature communications
Teng KW,Tsai ST,Hattori T,Fedele C,Koide A,Yang C,Hou X,Zhang Y,Neel BG,O'Bryan JP,Koide S
Tue May 11 00:00:00 EDT 2021
Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells.
Frontiers in cellular and infection microbiology
Shaharuddin SH,Wang V,Santos RS,Gross A,Wang Y,Jawanda H,Zhang Y,Hasan W,Garcia G,Arumugaswami V,Sareen D
Thu Jul 22 00:00:00 EDT 2021
3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model.
Cancers
Mokhtari RB,Qorri B,Sambi M,Baluch N,Kumar S,Das B,Szewczuk MR,Yeger H,Cheng HM
AF-100-15 was used in Cell Culture to investigate breast cancer cells cultured in stromal stem cell factor-supplemented media to generate 3D spheroids that exhibit increased stem-like properties.
Thu Jun 03 00:00:00 EDT 2021
Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling.
Cancer medicine
Jia M,Wang Y,Guo Y,Yu P,Sun Y,Song Y,Zhao L
Sat May 01 00:00:00 EDT 2021
Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts.
Scientific reports
Anzai K,Tsuruya K,Ida K,Kagawa T,Inagaki Y,Kamiya A
Fri Sep 17 00:00:00 EDT 2021
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Nature communications
Badodi S,Pomella N,Zhang X,Rosser G,Whittingham J,Niklison-Chirou MV,Lim YM,Brandner S,Morrison G,Pollard SM,Bennett CD,Clifford SC,Peet A,Basson MA,Marino S
Mon Apr 12 00:00:00 EDT 2021
Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling.
Cell reports
Chen J,Dong X,Cheng X,Zhu Q,Zhang J,Li Q,Huang X,Wang M,Li L,Guo W,Sun B,Shu Q,Yi W,Li X
Tue Mar 30 00:00:00 EDT 2021
Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple-Negative Breast Cancer Tumor Growth.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Y,Zhou Y,Ma X,Chen L
Mon Feb 01 00:00:00 EST 2021
Quantitative Consequences of Protein Carriers in Immunopeptidomics and Tyrosine Phosphorylation MS2 Analyses.
Molecular & cellular proteomics : MCP
Stopfer LE,Conage-Pough JE,White FM
Mon Mar 21 00:00:00 EDT 2022
CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling.
Cell death & disease
Huang Z,Yan Y,Zhu Z,Liu J,He X,Dalangood S,Li M,Tan M,Cai J,Tang P,Huang R,Shen B,Yan J
Tue May 25 00:00:00 EDT 2021
Cilium induction triggers differentiation of glioma stem cells.
Cell reports
Goranci-Buzhala G,Mariappan A,Ricci-Vitiani L,Josipovic N,Pacioni S,Gottardo M,Ptok J,Schaal H,Callaini G,Rajalingam K,Dynlacht B,Hadian K,Papantonis A,Pallini R,Gopalakrishnan J
Tue Sep 07 00:00:00 EDT 2021
An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement.
Communications biology
O'Donnell JC,Purvis EM,Helm KVT,Adewole DO,Zhang Q,Le AD,Cullen DK
Thu Jul 15 00:00:00 EDT 2021
TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration.
Cell reports
Russ K,Teku G,Bousset L,Redeker V,Piel S,Savchenko E,Pomeshchik Y,Savistchenko J,Stummann TC,Azevedo C,Collin A,Goldwurm S,Fog K,Elmer E,Vihinen M,Melki R,Roybon L
Tue Mar 23 00:00:00 EDT 2021
Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.
Cell death and differentiation
Manic G,Musella M,Corradi F,Sistigu A,Vitale S,Soliman Abdel Rehim S,Mattiello L,Malacaria E,Galassi C,Signore M,Pallocca M,Scalera S,Goeman F,De Nicola F,Guarracino A,Pennisi R,Antonangeli F,Sperati F,Baiocchi M,Biffoni M,Fanciulli M,Maugeri-Saccà M,Franchitto A,Pichierri P,De Maria R,Vitale I
Thu Jul 01 00:00:00 EDT 2021
Transcription factor enrichment analysis (TFEA) quantifies the activity of multiple transcription factors from a single experiment.
Communications biology
Rubin JD,Stanley JT,Sigauke RF,Levandowski CB,Maas ZL,Westfall J,Taatjes DJ,Dowell RD
Wed Jun 02 00:00:00 EDT 2021
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling.
Frontiers in immunology
Wurzer H,Filali L,Hoffmann C,Krecke M,Biolato AM,Mastio J,De Wilde S,François JH,Largeot A,Berchem G,Paggetti J,Moussay E,Thomas C
AF-100-15 was used in Cell Culture to study the role of the chronic lymphocytic leukemia (CLL) cell actin cytoskeleton during natural killer (NK) cell attack to show CLL cells can undergo fast actin cytoskeleton remodeling which is characterized by a NK cell contact-induced accumulation of actin filaments at the immunological synapse (IS).
Mon Jun 28 00:00:00 EDT 2021
Cell cycle inertia underlies a bifurcation in cell fates after DNA damage.
Science advances
Nathans JF,Cornwell JA,Afifi MM,Paul D,Cappell SD
AF-100-15 was used in Cell Culture to demonstrate that DNA damage leads to highly variable and divergent fate outcomes and necessitate a revised model of DNA damage response in G1 phase and indicate that cells have a G1 checkpoint.
Fri Jan 01 00:00:00 EST 2021
βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells.
Communications biology
Shang P,Stepicheva N,Teel K,McCauley A,Fitting CS,Hose S,Grebe R,Yazdankhah M,Ghosh S,Liu H,Strizhakova A,Weiss J,Bhutto IA,Lutty GA,Jayagopal A,Qian J,Sahel JA,Samuel Zigler J,Handa JT,Sergeev Y,Rajala RVS,Watkins S,Sinha D
Thu Jul 08 00:00:00 EDT 2021
The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus.
Cell reports
Gupta B,Errington AC,Jimenez-Pascual A,Eftychidis V,Brabletz S,Stemmler MP,Brabletz T,Petrik D,Siebzehnrubl FA
Tue Aug 24 00:00:00 EDT 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 EDT 2021
Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cells.
Scientific reports
Liang YH,Wu JM,Teng JW,Hung E,Wang HS
Mon Jul 19 00:00:00 EDT 2021
Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.
Cell reports. Medicine
Hamel Y,Mauvais FX,Madrange M,Renard P,Lebreton C,Nemazanyy I,Pellé O,Goudin N,Tang X,Rodero MP,Tuchmann-Durand C,Nusbaum P,Brindley DN,van Endert P,de Lonlay P
Tue Aug 17 00:00:00 EDT 2021
Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.
Scientific reports
Akasu M,Shimada S,Kabashima A,Akiyama Y,Shimokawa M,Akahoshi K,Kudo A,Yamaoka S,Tanabe M,Tanaka S
Tue Aug 24 00:00:00 EDT 2021
CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini.
Cell discovery
Wang H,Huang R,Li L,Zhu J,Li Z,Peng C,Zhuang X,Lin H,Shi S,Huang P
Mon Apr 19 00:00:00 EDT 2021
Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single-Cell Analysis of Transcriptome and Telomeres.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Wang H,Gong P,Chen T,Gao S,Wu Z,Wang X,Li J,Marjani SL,Costa J,Weissman SM,Qi F,Pan X,Liu L
Thu Apr 01 00:00:00 EDT 2021
SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
Nature communications
Kim JH,Jeong K,Li J,Murphy JM,Vukadin L,Stone JK,Richard A,Tran J,Gillespie GY,Flemington EK,Sobol RW,Lim SS,Ahn EE
Tue Sep 21 00:00:00 EDT 2021
Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer.
Communications biology
Namba S,Ueno T,Kojima S,Kobayashi K,Kawase K,Tanaka Y,Inoue S,Kishigami F,Kawashima S,Maeda N,Ogawa T,Hazama S,Togashi Y,Ando M,Shiraishi Y,Mano H,Kawazu M
Mon Nov 22 00:00:00 EST 2021
Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level.
Nature communications
Clark HR,McKenney C,Livingston NM,Gershman A,Sajjan S,Chan IS,Ewald AJ,Timp W,Wu B,Singh A,Regot S
Tue Mar 23 00:00:00 EDT 2021
LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells.
eLife
Chen BR,Wang Y,Tubbs A,Zong D,Fowler FC,Zolnerowich N,Wu W,Bennett A,Chen CC,Feng W,Nussenzweig A,Tyler JK,Sleckman BP
AF-100-15 was used in Cell Culture to investigate whether pathways exist in addition to 53BP1 and RIF1/shieldin that protect DNA ends and pro- mote genome integrity by preventing aberrant homology-mediated DSB.
Fri Sep 03 00:00:00 EDT 2021
Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival.
eLife
Guilhamon P,Chesnelong C,Kushida MM,Nikolic A,Singhal D,MacLeod G,Madani Tonekaboni SA,Cavalli FM,Arlidge C,Rajakulendran N,Rastegar N,Hao X,Hassam R,Smith LJ,Whetstone H,Coutinho FJ,Nadorp B,Ellestad KI,Luchman HA,Chan JA,Shoichet MS,Taylor MD,Haibe-Kains B,Weiss S,Angers S,Gallo M,Dirks PB,Lupien M
AF-100-15 was used in Sample Preparation to conclude that our chromatin-driven characterization of GSC states improves prognostic precision and identifies dependencies to guide combination therapies.
Mon Jan 11 00:00:00 EST 2021
On the role of p53 in the cellular response to aneuploidy.
Cell reports
Narkar A,Johnson BA,Bharne P,Zhu J,Padmanaban V,Biswas D,Fraser A,Iglesias PA,Ewald AJ,Li R
Tue Mar 23 00:00:00 EDT 2021
Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates.
Cell discovery
Chen H,Xia K,Huang W,Li H,Wang C,Ma Y,Chen J,Luo P,Zheng S,Wang J,Wang Y,Dong L,Tan Z,Lai X,Mao FF,Li W,Liang X,Wang T,Xiang AP,Ke Q
Tue Aug 31 00:00:00 EDT 2021
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Cell reports
Nakashima H,Tsujimura K,Irie K,Imamura T,Trujillo CA,Ishizu M,Uesaka M,Pan M,Noguchi H,Okada K,Aoyagi K,Andoh-Noda T,Okano H,Muotri AR,Nakashima K
Tue May 18 00:00:00 EDT 2021
ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.
Cell death discovery
Zhu T,Zheng J,Zhuo W,Pan P,Li M,Zhang W,Zhou H,Gao Y,Li X,Liu Z
Sat May 29 00:00:00 EDT 2021
Generation of proliferating human adult hepatocytes using optimized 3D culture conditions.
Scientific reports
Rose S,Ezan F,Cuvellier M,Bruyère A,Legagneux V,Langouët S,Baffet G
Tue Jan 12 00:00:00 EST 2021
Prrx1 promotes stemness and angiogenesis via activating TGF-β/smad pathway and upregulating proangiogenic factors in glioma.
Cell death & disease
Chen Z,Chen Y,Li Y,Lian W,Zheng K,Zhang Y,Zhang Y,Lin C,Liu C,Sun F,Sun X,Wang J,Zhao L,Ke Y
Tue Jun 15 00:00:00 EDT 2021
Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations.
Cell reports
Gil-Ranedo J,Gallego-García C,Almendral JM
Tue Sep 07 00:00:00 EDT 2021
Endocytic protein intersectin1-S shuttles into nucleus to suppress the DNA replication in breast cancer.
Cell death & disease
Zhang H,Guo Z,Liu X,Zhao Y,Chen Y,Zhang M,Fu L,Gu F,Ma Y
Fri Oct 08 00:00:00 EDT 2021
Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells.
Nature communications
Liu H,Li R,Liao HK,Min Z,Wang C,Yu Y,Shi L,Dan J,Hayek A,Martinez Martinez L,Nuñez Delicado E,Izpisua Belmonte JC
Mon Jun 07 00:00:00 EDT 2021
Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models.
Cell death & disease
Clark MP,Huynh T,Rao S,Mackiewicz L,Mason H,Romal S,Stutz MD,Ahn SH,Earnest L,Sozzi V,Littlejohn M,Tran BM,Wiedemann N,Vincan E,Torresi J,Netter HJ,Mahmoudi T,Revill P,Pellegrini M,Ebert G
Wed Jun 23 00:00:00 EDT 2021
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.
Nature communications
Wu Y,Zhang C,Liu X,He Z,Shan B,Zeng Q,Zhao Q,Zhu H,Liao H,Cen X,Xu X,Zhang M,Hou T,Wang Z,Yan H,Yang S,Sun Y,Chen Y,Wu R,Xie T,Chen W,Najafov A,Ying S,Xia H
Tue Apr 20 00:00:00 EDT 2021
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.
Nature communications
Wu Y,Zhang C,Liu X,He Z,Shan B,Zeng Q,Zhao Q,Zhu H,Liao H,Cen X,Xu X,Zhang M,Hou T,Wang Z,Yan H,Yang S,Sun Y,Chen Y,Wu R,Xie T,Chen W,Najafov A,Ying S,Xia H
Tue Apr 20 00:00:00 EDT 2021
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.
Scientific reports
Shono K,Mizobuchi Y,Yamaguchi I,Nakajima K,Fujiwara Y,Fujihara T,Kitazato K,Matsuzaki K,Uto Y,Sampetrean O,Saya H,Takagi Y
Fri Jul 23 00:00:00 EDT 2021
Apatinib suppresses lung cancer stem-like cells by complex interplay between β-catenin signaling and mitochondrial ROS accumulation.
Cell death discovery
Zhu J,Li X,Liang C,Zhou X,Ge M,Chen Y,Jin J,Yin J,Xu H,Xie C,Zhong C
Wed May 12 00:00:00 EDT 2021
Genome-wide association studies identify the role of caspase-9 in kidney disease.
Science advances
Doke T,Huang S,Qiu C,Sheng X,Seasock M,Liu H,Ma Z,Palmer M,Susztak K
AF-100-15 was used in Cell Culture to study the pathways causal genes, cell types, and pathways involved in kidney dysfunction to prioritize CASP9 as an eGFR GWAS target gene role and to show the role of CASP9 in kidney disease development via improving mitophagy and lowering inflammation and apoptosis.
Fri Nov 05 00:00:00 EDT 2021
Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models.
Breast cancer research : BCR
Chew NJ,Lim Kam Sian TCC,Nguyen EV,Shin SY,Yang J,Hui MN,Deng N,McLean CA,Welm AL,Lim E,Gregory P,Nottle T,Lang T,Vereker M,Richardson G,Kerr G,Micati D,Jardé T,Abud HE,Lee RS,Swarbrick A,Daly RJ
AF-100-15 was used in Cell Culture to highlight how patient-derived models of human breast cancer provide powerful platforms for therapeutic target identification and analysis of drug action, and also the potential of specific FGFRs, including FGFR4, as targets for precision treatment.
Tue Aug 03 00:00:00 EDT 2021
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity.
Communications biology
Mandrup OA,Ong SC,Lykkemark S,Dinesen A,Rudnik-Jansen I,Dagnæs-Hansen NF,Andersen JT,Alvarez-Vallina L,Howard KA
Mon Mar 08 00:00:00 EST 2021
BASP1 labels neural stem cells in the neurogenic niches of mammalian brain.
Scientific reports
Manganas LN,Durá I,Osenberg S,Semerci F,Tosun M,Mishra R,Parkitny L,Encinas JM,Maletic-Savatic M
Wed Mar 10 00:00:00 EST 2021
Patient Derived Colonoids as Drug Testing Platforms-Critical Importance of Oxygen Concentration.
Frontiers in pharmacology
Skovdahl HK,Gopalakrishnan S,Svendsen TD,Granlund AVB,Bakke I,Ginbot ZG,Thorsvik S,Flatberg A,Sporsheim B,Ostrop J,Mollnes TE,Sandvik AK,Bruland T
AF-100-15 was used in Cell Culture to indicate that an oxygen concentration similar to the in vivo epithelial cell environment is of essence in experimental pharmacology.
Tue Jun 01 00:00:00 EDT 2021
Protocol for automated production of human stem cell derived liver spheres.
STAR protocols
Meseguer-Ripolles J,Kasarinaite A,Lucendo-Villarin B,Hay DC
Fri Jun 18 00:00:00 EDT 2021
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
Nature communications
Guan Y,Liang X,Ma Z,Hu H,Liu H,Miao Z,Linkermann A,Hellwege JN,Voight BF,Susztak K
Mon Aug 23 00:00:00 EDT 2021
Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis.
Cell reports
Yucer N,Ahdoot R,Workman MJ,Laperle AH,Recouvreux MS,Kurowski K,Naboulsi DJ,Liang V,Qu Y,Plummer JT,Gayther SA,Orsulic S,Karlan BY,Svendsen CN
AF-100-15 was used in Cell Culture to generate induced pluripotent stem cells (iPSCs) from healthy individuals and young ovarian cancer patients with germline pathogenic BRCA1 mutations (BRCA1mut).
Tue Dec 28 00:00:00 EST 2021
Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression.
Nature communications
Bolis M,Bossi D,Vallerga A,Ceserani V,Cavalli M,Impellizzieri D,Di Rito L,Zoni E,Mosole S,Elia AR,Rinaldi A,Pereira Mestre R,D'Antonio E,Ferrari M,Stoffel F,Jermini F,Gillessen S,Bubendorf L,Schraml P,Calcinotto A,Corey E,Moch H,Spahn M,Thalmann G,Kruithof-de Julio M,Rubin MA,Theurillat JP
AF-100-15 was used in Cell Culture to provide a user-friendly web-resource enabling the investigation of dynamic transcriptional perturbations linked to disease progression.
Thu Dec 02 00:00:00 EST 2021
Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist.
Cell death & disease
Boccellato C,Kolbe E,Peters N,Juric V,Fullstone G,Verreault M,Idbaih A,Lamfers MLM,Murphy BM,Rehm M
Thu Jun 24 00:00:00 EDT 2021
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders.
Nature communications
Afshar Y,Dong J,Zhao P,Li L,Wang S,Zhang RY,Zhang C,Yin O,Han CS,Einerson BD,Gonzalez TL,Zhang H,Zhou A,Yang Z,Chou SJ,Sun N,Cheng J,Zhu H,Wang J,Zhang TX,Lee YT,Wang JJ,Teng PC,Yang P,Qi D,Zhao M,Sim MS,Zhe R,Goldstein JD,Williams J,Wang X,Zhang Q,Platt LD,Zou C,Pisarska MD,Tseng HR,Zhu Y
Tue Aug 03 00:00:00 EDT 2021
Generation of Neurosphere-Derived Organoid-Like-Aggregates (NEDAS) from Neural Stem Cells.
Current protocols
Watanabe F,Schoeffler A,Fair SR,Hester ME,Fedorko J,Imitola J
Mon Feb 01 00:00:00 EST 2021
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Nature communications
Leach JDG,Vlahov N,Tsantoulis P,Ridgway RA,Flanagan DJ,Gilroy K,Sphyris N,Vázquez EG,Vincent DF,Faller WJ,Hodder MC,Raven A,Fey S,Najumudeen AK,Strathdee D,Nixon C,Hughes M,Clark W,Shaw R,van Hooff SR,Huels DJ,Medema JP,Barry ST,Frame MC,Unciti-Broceta A,Leedham SJ,Inman GJ,Jackstadt R,Thompson BJ,Campbell AD,Tejpar S,Sansom OJ
Tue Jun 08 00:00:00 EDT 2021
CREB signaling activity correlates with differentiation and survival in medulloblastoma.
Scientific reports
Armandari I,Zomerman WW,Plasschaert SLA,Smit MJ,Martini TEI,de Camargo Magalhães ES,Hogeling SM,Rozema-Huizinga GC,Lourens HJ,Meeuwsen-de Boer TGJ,Scherpen FJG,de Bont ESJM,Bruggeman SWM
Mon Aug 09 00:00:00 EDT 2021
RANK promotes colorectal cancer migration and invasion by activating the Ca2+-calcineurin/NFATC1-ACP5 axis.
Cell death & disease
Liang Q,Wang Y,Lu Y,Zhu Q,Xie W,Tang N,Huang L,An T,Zhang D,Yan A,Liu S,Ye L,Zhu C
Thu Apr 01 00:00:00 EDT 2021
Role and dynamics of vacuolar pH during cell-in-cell mediated death.
Cell death & disease
Su Y,Ren H,Tang M,Zheng Y,Zhang B,Wang C,Hou X,Niu Z,Wang Z,Gao X,Gao L,Jiang H,Chen Z,Luo T,Sun Q
Fri Jan 22 00:00:00 EST 2021
CD44 expression in the tumor periphery predicts the responsiveness to bevacizumab in the treatment of recurrent glioblastoma.
Cancer medicine
Nishikawa M,Inoue A,Ohnishi T,Yano H,Kanemura Y,Kohno S,Ohue S,Ozaki S,Matsumoto S,Suehiro S,Nakamura Y,Shigekawa S,Watanabe H,Kitazawa R,Tanaka J,Kunieda T
Mon Mar 01 00:00:00 EST 2021
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.
Nature communications
Nielsen SR,Strøbech JE,Horton ER,Jackstadt R,Laitala A,Bravo MC,Maltese G,Jensen ARD,Reuten R,Rafaeva M,Karim SA,Hwang CI,Arnes L,Tuveson DA,Sansom OJ,Morton JP,Erler JT
AF-100-15 was used in Cell Culture to evaluate lorlatinib attenuates for the treatment of PDAC mouse models.
Mon Jun 07 00:00:00 EDT 2021
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.
Nature communications
Nielsen SR,Strøbech JE,Horton ER,Jackstadt R,Laitala A,Bravo MC,Maltese G,Jensen ARD,Reuten R,Rafaeva M,Karim SA,Hwang CI,Arnes L,Tuveson DA,Sansom OJ,Morton JP,Erler JT
AF-100-15 was used in Cell Culture to evaluate lorlatinib attenuates for the treatment of PDAC mouse models.
Mon Jun 07 00:00:00 EDT 2021
Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells.
Cell death & disease
An H,Heo JS,Kim P,Lian Z,Lee S,Park J,Hong E,Pang K,Park Y,Ooshima A,Lee J,Son M,Park H,Wu Z,Park KS,Kim SJ,Bae I,Yang KM
Mon Feb 08 00:00:00 EST 2021
Distinct roles of tumor associated mutations in collective cell migration.
Scientific reports
Lee RM,Vitolo MI,Losert W,Martin SS
Thu May 13 00:00:00 EDT 2021
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide.
Nature communications
Li F,Han M,Dai P,Xu W,He J,Tao X,Wu Y,Tong X,Xia X,Guo W,Zhou Y,Li Y,Zhu Y,Zhang X,Liu Z,Aji R,Cai X,Li Y,Qu D,Chen Y,Jiang S,Wang Q,Ji H,Xie Y,Sun Y,Lu L,Gao D
Mon Feb 08 00:00:00 EST 2021
HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.
eLife
Ho JS,Di Tullio F,Schwarz M,Low D,Incarnato D,Gay F,Tabaglio T,Zhang J,Wollmann H,Chen L,An O,Chan THM,Hall Hickman A,Zheng S,Roudko V,Chen S,Karz A,Ahmed M,He HH,Greenbaum BD,Oliviero S,Serresi M,Gargiulo G,Mann KM,Hernando E,Mulholland D,Marazzi I,Wee DKB,Guccione E
AF-100-15 was used in Cell Culture to investigate splicing activity in cancer cells.
Wed Jun 02 00:00:00 EDT 2021
Directed Differentiation of Human Pluripotent Stem Cells toward Skeletal Myogenic Progenitors and Their Purification Using Surface Markers.
Cells
Xu N,Wu J,Ortiz-Vitali JL,Li Y,Darabi R
AF-100-15 was used in In vitro experiments to develop an improved directed differentiation method for the derivation of skeletal myogenic progenitors from Human Pluripotent Stem Cells.
Thu Oct 14 00:00:00 EDT 2021
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours.
Nature communications
Custers L,Khabirova E,Coorens THH,Oliver TRW,Calandrini C,Young MD,Vieira Braga FA,Ellis P,Mamanova L,Segers H,Maat A,Kool M,Hoving EW,van den Heuvel-Eibrink MM,Nicholson J,Straathof K,Hook L,de Krijger RR,Trayers C,Allinson K,Behjati S,Drost J
Wed Mar 03 00:00:00 EST 2021
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.
eLife
Perez-Garcia V,Lea G,Lopez-Jimenez P,Okkenhaug H,Burton GJ,Moffett A,Turco MY,Hemberger M
AF-100-15 was used in Cell Culture to explore how BRCA1-associated protein 1 regulates trophoblast biology in placental development.
Fri Jun 25 00:00:00 EDT 2021
Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer.
Science advances
Wan C,Mahara S,Sun C,Doan A,Chua HK,Xu D,Bian J,Li Y,Zhu D,Sooraj D,Cierpicki T,Grembecka J,Firestein R
AF-100-15 was used in Cell Culture to show that KMT2A loss diminishes the binding of β-catenin to consensus DNA motifs and the transcription of β-catenin targets in CRC.
Sat May 01 00:00:00 EDT 2021
Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
Cell reports
Calandrini C,van Hooff SR,Paassen I,Ayyildiz D,Derakhshan S,Dolman MEM,Langenberg KPS,van de Ven M,de Heus C,Liv N,Kool M,de Krijger RR,Tytgat GAM,van den Heuvel-Eibrink MM,Molenaar JJ,Drost J
Tue Aug 24 00:00:00 EDT 2021
Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Chen P,Zhang X,Ding R,Yang L,Lyu X,Zeng J,Lei JH,Wang L,Bi J,Shao N,Shu D,Wu B,Wu J,Yang Z,Wang H,Wang B,Xiong K,Lu Y,Fu S,Choi TK,Lon NW,Zhang A,Tang D,Quan Y,Meng Y,Miao K,Sun H,Zhao M,Bao J,Zhang L,Xu X,Shi Y,Lin Y,Deng C
Mon Nov 01 00:00:00 EDT 2021
Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma.
Scientific reports
Schwinn S,Mokhtari Z,Thusek S,Schneider T,Sirén AL,Tiemeyer N,Caruana I,Miele E,Schlegel PG,Beilhack A,Wölfl M
Wed Jul 07 00:00:00 EDT 2021
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas.
Nature communications
Amoozgar Z,Kloepper J,Ren J,Tay RE,Kazer SW,Kiner E,Krishnan S,Posada JM,Ghosh M,Mamessier E,Wong C,Ferraro GB,Batista A,Wang N,Badeaux M,Roberge S,Xu L,Huang P,Shalek AK,Fukumura D,Kim HJ,Jain RK
Tue May 11 00:00:00 EDT 2021
Inhibition of the PLK1-Coupled Cell Cycle Machinery Overcomes Resistance to Oxaliplatin in Colorectal Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Yu Z,Deng P,Chen Y,Liu S,Chen J,Yang Z,Chen J,Fan X,Wang P,Cai Z,Wang Y,Hu P,Lin D,Xiao R,Zou Y,Huang Y,Yu Q,Lan P,Tan J,Wu X
Wed Dec 01 00:00:00 EST 2021
Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.
Communications biology
Nguyen L,Jager M,Lieshout R,de Ruiter PE,Locati MD,Besselink N,van der Roest B,Janssen R,Boymans S,de Jonge J,IJzermans JNM,Doukas M,Verstegen MMA,van Boxtel R,van der Laan LJW,Cuppen E,Kuijk E
Thu Nov 18 00:00:00 EST 2021
NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer.
Communications biology
Pappas K,Martin TC,Wolfe AL,Nguyen CB,Su T,Jin J,Hibshoosh H,Parsons R
Tue Mar 09 00:00:00 EST 2021
The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells.
Cancer communications (London, England)
Liu Z,Ning F,Cai Y,Sheng H,Zheng R,Yin X,Lu Z,Su L,Chen X,Zeng C,Wang H,Liu L
Fri Jan 01 00:00:00 EST 2021
Deregulation of protein phosphatase 2A inhibitor SET is associated with malignant progression in breast cancer.
Scientific reports
Tozuka K,Wongsirisin P,Nagai SE,Kobayashi Y,Kanno M,Kubo K,Takai K,Inoue K,Matsumoto H,Shimizu Y,Suganuma M
Fri Jul 09 00:00:00 EDT 2021
GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small-cell lung cancer.
Cell death & disease
Song JW,Zhu J,Wu XX,Tu T,Huang JQ,Chen GZ,Liang LY,Zhou CH,Xu X,Gong LY
Thu Oct 21 00:00:00 EDT 2021
P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas.
Nature communications
Rousso-Noori L,Mastandrea I,Talmor S,Waks T,Globerson Levin A,Haugas M,Teesalu T,Alvarez-Vallina L,Eshhar Z,Friedmann-Morvinski D
Mon Jun 14 00:00:00 EDT 2021
A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions.
Scientific reports
Rogers MT,Gard AL,Gaibler R,Mulhern TJ,Strelnikov R,Azizgolshani H,Cain BP,Isenberg BC,Haroutunian NJ,Raustad NE,Keegan PM,Lech MP,Tomlinson L,Borenstein JT,Charest JL,Williams C
Wed Jun 09 00:00:00 EDT 2021
CODEX, a neural network approach to explore signaling dynamics landscapes.
Molecular systems biology
Jacques MA,Dobrzyński M,Gagliardi PA,Sznitman R,Pertz O
Thu Apr 01 00:00:00 EDT 2021
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
Communications biology
Qiu R,Wu J,Gudenas B,Northcott PA,Wechsler-Reya RJ,Lu Q
Tue May 11 00:00:00 EDT 2021
Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury.
Cell reports
Liberti DC,Kremp MM,Liberti WA,Penkala IJ,Li S,Zhou S,Morrisey EE
Tue May 11 00:00:00 EDT 2021
Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury.
Cell reports
Liberti DC,Kremp MM,Liberti WA,Penkala IJ,Li S,Zhou S,Morrisey EE
Tue May 11 00:00:00 EDT 2021
Microscopy-guided laser ablation for the creation of complex skin models with folliculoid appendages.
Bioengineering & translational medicine
Abreu CM,Gasperini L,Lago MEL,Reis RL,Marques AP
Sat May 01 00:00:00 EDT 2021
GD2 CAR T cells against human glioblastoma.
NPJ precision oncology
Prapa M,Chiavelli C,Golinelli G,Grisendi G,Bestagno M,Di Tinco R,Dall'Ora M,Neri G,Candini O,Spano C,Petrachi T,Bertoni L,Carnevale G,Pugliese G,Depenni R,Feletti A,Iaccarino C,Pavesi G,Dominici M
Wed Oct 27 00:00:00 EDT 2021
GD2 CAR T cells against human glioblastoma.
NPJ precision oncology
Prapa M,Chiavelli C,Golinelli G,Grisendi G,Bestagno M,Di Tinco R,Dall'Ora M,Neri G,Candini O,Spano C,Petrachi T,Bertoni L,Carnevale G,Pugliese G,Depenni R,Feletti A,Iaccarino C,Pavesi G,Dominici M
Wed Oct 27 00:00:00 EDT 2021
EGFR transactivates RON to drive oncogenic crosstalk.
eLife
Franco Nitta C,Green EW,Jhamba ED,Keth JM,Ortiz-Caraveo I,Grattan RM,Schodt DJ,Gibson AC,Rajput A,Lidke KA,Wilson BS,Steinkamp MP,Lidke DS
AF-100-15 was used in In vitro experiments to study the mechanism behind the crosstalk between the EGFR and RON are two such receptor tyrosine kinases (RTKs) to show that RON is a substrate for EGFR kinase, and that transactivation of RON requires formation of a signaling competent EGFR dimer.
Thu Nov 25 00:00:00 EST 2021
EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.
Cancers
Bleijs M,Pleijte C,Engels S,Ringnalda F,Meyer-Wentrup F,van de Wetering M,Clevers H
AF-100-15 was used in Cell Culture to investigate potential treatment for desmoplastic small round cell tumour.
Thu Dec 02 00:00:00 EST 2021
Neuroblastoma and DIPG Organoid Coculture System for Personalized Assessment of Novel Anticancer Immunotherapies.
Journal of personalized medicine
M Kholosy W,Derieppe M,van den Ham F,Ober K,Su Y,Custers L,Schild L,M J van Zogchel L,M Wellens L,R Ariese H,Szanto CL,Wienke J,Dierselhuis MP,van Vuurden D,Dolman EM,Molenaar JJ
AF-100-15 was used in Cell Culture to provide a procedure for the establishment of an ex vivo test coculture system of paediatric tumour organoids and immune cells that enables the assessment of different immunotherpay approaches in paediatric tumour organoids.
Mon Aug 30 00:00:00 EDT 2021
Widespread Alternative Splicing Changes in Metastatic Breast Cancer Cells.
Cells
Oh J,Pradella D,Shao C,Li H,Choi N,Ha J,Ruggiero S,Fu XD,Zheng X,Ghigna C,Shen H
AF-100-15 was used in Cell Culture to investigate aberrant alternative splicing in breast cancer progression.
Fri Apr 09 00:00:00 EDT 2021
Augmented Therapeutic Potential of Glutaminase Inhibitor CB839 in Glioblastoma Stem Cells Using Gold Nanoparticle Delivery.
Pharmaceutics
Giesen B,Nickel AC,Barthel J,Kahlert UD,Janiak C
AF-100-15 was used in Cell Culture to study combining CB839 with Au nanotechnology.
Tue Feb 23 00:00:00 EST 2021
Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip.
Nature protocols
Gijzen L,Yousef Yengej FA,Schutgens F,Vormann MK,Ammerlaan CME,Nicolas A,Kurek D,Vulto P,Rookmaaker MB,Lanz HL,Verhaar MC,Clevers H
AF-100-15 was used in Cell Culture to establish kidney tubloid culture from tissue and urine, and generate and characterise tabloid cell-derived 3D tubular structures in a perfused microfluidic multi-chip platform.
Thu Apr 01 00:00:00 EDT 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Nature communications
Tajan M,Hennequart M,Cheung EC,Zani F,Hock AK,Legrave N,Maddocks ODK,Ridgway RA,Athineos D,Suárez-Bonnet A,Ludwig RL,Novellasdemunt L,Angelis N,Li VSW,Vlachogiannis G,Valeri N,Mainolfi N,Suri V,Friedman A,Manfredi M,Blyth K,Sansom OJ,Vousden KH
Thu Jan 14 00:00:00 EST 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Nature communications
Tajan M,Hennequart M,Cheung EC,Zani F,Hock AK,Legrave N,Maddocks ODK,Ridgway RA,Athineos D,Suárez-Bonnet A,Ludwig RL,Novellasdemunt L,Angelis N,Li VSW,Vlachogiannis G,Valeri N,Mainolfi N,Suri V,Friedman A,Manfredi M,Blyth K,Sansom OJ,Vousden KH
Thu Jan 14 00:00:00 EST 2021
Oviduct epithelial cells constitute two developmentally distinct lineages that are spatially separated along the distal-proximal axis.
Cell reports
Ford MJ,Harwalkar K,Pacis AS,Maunsell H,Wang YC,Badescu D,Teng K,Yamanaka N,Bouchard M,Ragoussis J,Yamanaka Y
Tue Sep 07 00:00:00 EDT 2021
Patient-derived xenografts and organoids model therapy response in prostate cancer.
Nature communications
Karkampouna S,La Manna F,Benjak A,Kiener M,De Menna M,Zoni E,Grosjean J,Klima I,Garofoli A,Bolis M,Vallerga A,Theurillat JP,De Filippo MR,Genitsch V,Keller D,Booij TH,Stirnimann CU,Eng K,Sboner A,Ng CKY,Piscuoglio S,Gray PC,Spahn M,Rubin MA,Thalmann GN,Kruithof-de Julio M
Thu Feb 18 00:00:00 EST 2021
Improved Models of Human Endometrial Organoids Based on Hydrogels from Decellularized Endometrium.
Journal of personalized medicine
Francés-Herrero E,Juárez-Barber E,Campo H,López-Martínez S,de Miguel-Gómez L,Faus A,Pellicer A,Ferrero H,Cervelló I
Thu Jun 03 00:00:00 EDT 2021
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.
Cell reports
Waters AM,Khatib TO,Papke B,Goodwin CM,Hobbs GA,Diehl JN,Yang R,Edwards AC,Walsh KH,Sulahian R,McFarland JM,Kapner KS,Gilbert TSK,Stalnecker CA,Javaid S,Barkovskaya A,Grover KR,Hibshman PS,Blake DR,Schaefer A,Nowak KM,Klomp JE,Hayes TK,Kassner M,Tang N,Tanaseichuk O,Chen K,Zhou Y,Kalkat M,Herring LE,Graves LM,Penn LZ,Yin HH,Aguirre AJ,Hahn WC,Cox AD,Der CJ
Tue Jun 29 00:00:00 EDT 2021
Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition.
Nature communications
Zhang B,Wang L,Zhan A,Wang M,Tian L,Guo W,Pan Y
Fri Feb 19 00:00:00 EST 2021
YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer.
Scientific reports
Suzuki I,Yoshida S,Tabu K,Kusunoki S,Matsumura Y,Izumi H,Asanoma K,Yagi H,Onoyama I,Sonoda K,Kohno K,Taga T,Itakura A,Takeda S,Kato K
Thu Feb 18 00:00:00 EST 2021
GDF15 promotes glioma stem cell-like phenotype via regulation of ERK1/2-c-Fos-LIF signaling.
Cell death discovery
Zhu S,Yang N,Guan Y,Wang X,Zang G,Lv X,Deng S,Wang W,Li T,Chen J
Mon Jan 11 00:00:00 EST 2021
The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells.
The Journal of biological chemistry
Zhang M,Ji J,Wang X,Zhang X,Zhang Y,Li Y,Wang X,Li X,Ban Q,Ye SD
Fri Oct 01 00:00:00 EDT 2021
The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells.
The Journal of biological chemistry
Zhang M,Ji J,Wang X,Zhang X,Zhang Y,Li Y,Wang X,Li X,Ban Q,Ye SD
Fri Oct 01 00:00:00 EDT 2021
BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.
Nature communications
Githaka JM,Tripathi N,Kirschenman R,Patel N,Pandya V,Kramer DA,Montpetit R,Zhu LF,Sonenberg N,Fahlman RP,Danial NN,Underhill DA,Goping IS
Wed May 19 00:00:00 EDT 2021
BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.
Nature communications
Githaka JM,Tripathi N,Kirschenman R,Patel N,Pandya V,Kramer DA,Montpetit R,Zhu LF,Sonenberg N,Fahlman RP,Danial NN,Underhill DA,Goping IS
Wed May 19 00:00:00 EDT 2021
Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development.
Communications biology
Pocaterra A,Scattolin G,Romani P,Ament C,Ribback S,Chen X,Evert M,Calvisi DF,Dupont S
Mon Jun 21 00:00:00 EDT 2021
Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations.
Cell reports
Chen Z,Wu J,Liu B,Zhang G,Wang Z,Zhang L,Wang K,Fan Z,Zhu P
Tue Jul 27 00:00:00 EDT 2021
Molecular control of cell density-mediated exit to quiescence.
Cell reports
Fan Y,Meyer T
Tue Jul 27 00:00:00 EDT 2021
Rewiring of purine metabolism in response to acidosis stress in glioma stem cells.
Cell death & disease
Xu X,Wang L,Zang Q,Li S,Li L,Wang Z,He J,Qiang B,Han W,Zhang R,Peng X,Abliz Z
Mon Mar 15 00:00:00 EDT 2021
Low folate induces abnormal neuronal maturation and DNA hypomethylation of neuronal differentiation-related genes in cultured mouse neural stem and progenitor cells.
Heliyon
Araki R,Nishida S,Nakajima Y,Iwakumo A,Tachioka H,Kita A,Yabe T
Wed Sep 01 00:00:00 EDT 2021
Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas.
Cell reports
Isaev K,Jiang L,Wu S,Lee CA,Watters V,Fort V,Tsai R,Coutinho FJ,Hussein SMI,Zhang J,Wu J,Dirks PB,Schramek D,Reimand J
Tue Oct 19 00:00:00 EDT 2021
The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.
Cell death discovery
Lee KK,Rajagopalan D,Bhatia SS,Tirado-Magallanes R,Chng WJ,Jha S
Fri May 07 00:00:00 EDT 2021
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost.
Cell reports. Medicine
de Gooijer MC,Kemper EM,Buil LCM,Çitirikkaya CH,Buckle T,Beijnen JH,van Tellingen O
Tue Jan 19 00:00:00 EST 2021
Transcriptional cooperation of PBX1 and PAX6 in adult neural progenitor cells.
Scientific reports
Hau AC,Mommaerts E,Laub V,Müller T,Dittmar G,Schulte D
Mon Oct 25 00:00:00 EDT 2021
Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution.
Cell reports
Busslinger GA,Weusten BLA,Bogte A,Begthel H,Brosens LAA,Clevers H
Tue Mar 09 00:00:00 EST 2021
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia.
Translational psychiatry
Szabo A,Akkouh IA,Vandenberghe M,Osete JR,Hughes T,Heine V,Smeland OB,Glover JC,Andreassen OA,Djurovic S
Fri Oct 29 00:00:00 EDT 2021
Sorafenib and CuB exert synergistic antitumor effects against hepatocellular carcinoma cells via inhibition of STAT3 phosphorylation.
FEBS open bio
Wang X,Li H,Li D,Bai Y,Zhang Y,Yan X,Li J,Zhao R,Liu J,Liu W,Shi M,Xu C,Yang T,Zhang T
Fri Jan 01 00:00:00 EST 2021
Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua.
Cell reports
Cheung VC,Peng CY,Marinić M,Sakabe NJ,Aneas I,Lynch VJ,Ober C,Nobrega MA,Kessler JA
Tue May 18 00:00:00 EDT 2021
Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma.
Life science alliance
Regina C,Hamed E,Andrieux G,Angenendt S,Schneider M,Ku M,Follo M,Wachtel M,Ke E,Kikuchi K,Henssen AG,Schäfer BW,Boerries M,Wagers AJ,Keller C,Hettmer S
AF-100-15 was used in Cell Culture to study how heterogeneous expression of PAX3:FOXO1 at the single cell level may provide a critical advantage during tumor progression.
Wed Sep 01 00:00:00 EDT 2021
Generation of mixed murine organoids to model cellular interactions.
STAR protocols
Krotenberg Garcia A,van Rheenen J,Suijkerbuijk SJE
AF-100-15 was used in Cell Culture to design a protocol to generate mixed murine organoids and enteroid monolayers used to study such complex cellular interactions in a mammalian system.
Fri Dec 17 00:00:00 EST 2021
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Nature
Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ,Shido K,Spence JR,Zhou QJ,Schwartz RE,De Coppi P,Rabbany SY,Rafii S
Tue Sep 01 00:00:00 EDT 2020
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nature
Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP
Tue Sep 01 00:00:00 EDT 2020
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Cell
Koundouros N,Karali E,Tripp A,Valle A,Inglese P,Perry NJS,Magee DJ,Anjomani Virmouni S,Elder GA,Tyson AL,Dória ML,van Weverwijk A,Soares RF,Isacke CM,Nicholson JK,Glen RC,Takats Z,Poulogiannis G
AF-100-15 was used in Cell Culture to demonstrate a new mode of real-time diagnosis, coupling metabolic phenotype to mutant PIK3CA genotype.
Thu Jun 25 00:00:00 EDT 2020
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Cell
Koundouros N,Karali E,Tripp A,Valle A,Inglese P,Perry NJS,Magee DJ,Anjomani Virmouni S,Elder GA,Tyson AL,Dória ML,van Weverwijk A,Soares RF,Isacke CM,Nicholson JK,Glen RC,Takats Z,Poulogiannis G
AF-100-15 was used in Cell Culture to demonstrate a new mode of real-time diagnosis, coupling metabolic phenotype to mutant PIK3CA genotype.
Thu Jun 25 00:00:00 EDT 2020
Snake Venom Gland Organoids.
Cell
Post Y,Puschhof J,Beumer J,Kerkkamp HM,de Bakker MAG,Slagboom J,de Barbanson B,Wevers NR,Spijkers XM,Olivier T,Kazandjian TD,Ainsworth S,Iglesias CL,van de Wetering WJ,Heinz MC,van Ineveld RL,van Kleef RGDM,Begthel H,Korving J,Bar-Ephraim YE,Getreuer W,Rios AC,Westerink RHS,Snippert HJG,van Oudenaarden A,Peters PJ,Vonk FJ,Kool J,Richardson MK,Casewell NR,Clevers H
Thu Jan 23 00:00:00 EST 2020
Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts.
Cell
Crespo ÂC,Mulik S,Dotiwala F,Ansara JA,Sen Santara S,Ingersoll K,Ovies C,Junqueira C,Tilburgs T,Strominger JL,Lieberman J
Thu Sep 03 00:00:00 EDT 2020
High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.
Cell
Beumer J,Puschhof J,Bauzá-Martinez J,Martínez-Silgado A,Elmentaite R,James KR,Ross A,Hendriks D,Artegiani B,Busslinger GA,Ponsioen B,Andersson-Rolf A,Saftien A,Boot C,Kretzschmar K,Geurts MH,Bar-Ephraim YE,Pleguezuelos-Manzano C,Post Y,Begthel H,van der Linden F,Lopez-Iglesias C,van de Wetering WJ,van der Linden R,Peters PJ,Heck AJR,Goedhart J,Snippert H,Zilbauer M,Teichmann SA,Wu W,Clevers H
Thu Jun 11 00:00:00 EDT 2020
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Cancer cell
Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T
Mon Aug 10 00:00:00 EDT 2020
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers.
Cancer discovery
Li BT,Michelini F,Misale S,Cocco E,Baldino L,Cai Y,Shifman S,Tu HY,Myers ML,Xu C,Mattar M,Khodos I,Little M,Qeriqi B,Weitsman G,Wilhem CJ,Lalani AS,Diala I,Freedman RA,Lin NU,Solit DB,Berger MF,Barber PR,Ng T,Offin M,Isbell JM,Jones DR,Yu HA,Thyparambil S,Liao WL,Bhalkikar A,Cecchi F,Hyman DM,Lewis JS,Buonocore DJ,Ho AL,Makker V,Reis-Filho JS,Razavi P,Arcila ME,Kris MG,Poirier JT,Shen R,Tsurutani J,Ulaner GA,de Stanchina E,Rosen N,Rudin CM,Scaltriti M
AF-100-15 was used in Cell Culture to address unmet needs of patients with HER2-activated tumors and no approved targeted therapy.
Fri May 01 00:00:00 EDT 2020
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer.
Signal transduction and targeted therapy
Zheng Y,Wu C,Yang J,Zhao Y,Jia H,Xue M,Xu D,Yang F,Fu D,Wang C,Hu B,Zhang Z,Li T,Yan S,Wang X,Nelson PJ,Bruns C,Qin L,Dong Q
Wed May 13 00:00:00 EDT 2020
Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma.
Signal transduction and targeted therapy
Li L,Yang L,Fan Z,Xue W,Shen Z,Yuan Y,Sun X,Wang D,Lian J,Wang L,Zhao J,Zhang Y
Fri May 22 00:00:00 EDT 2020
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Signal transduction and targeted therapy
Ouyang L,Yan B,Liu Y,Mao C,Wang M,Liu N,Wang Z,Liu S,Shi Y,Chen L,Wang X,Cheng Y,Cao Y,Xiao D,Zhang L,Liu S,Tao Y
Wed Jun 17 00:00:00 EDT 2020
Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit.
Cell stem cell
Morrow CS,Porter TJ,Xu N,Arndt ZP,Ako-Asare K,Heo HJ,Thompson EAN,Moore DL
AF-100-15 was used in Cell Culture to demonstrate that adult neural stem cells (NSCs) utilize aggresomes to recover from disrupted proteostasis and describe a novel function for the intermediate filament vimentin in proteostasis as a spatial coordinator of proteasomes to the aggresome.
Thu Apr 02 00:00:00 EDT 2020
Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras.
Cell stem cell
Cohen MA,Zhang S,Sengupta S,Ma H,Bell GW,Horton B,Sharma B,George RE,Spranger S,Jaenisch R
AF-100-15 was used in Sample Preparation to develop an experimental platform for studying neuroblastoma using mouse-human neural crest chimeras.
Thu Apr 02 00:00:00 EDT 2020
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Cell stem cell
Youk J,Kim T,Evans KV,Jeong YI,Hur Y,Hong SP,Kim JH,Yi K,Kim SY,Na KJ,Bleazard T,Kim HM,Fellows M,Mahbubani KT,Saeb-Parsy K,Kim SY,Kim YT,Koh GY,Choi BS,Ju YS,Lee JH
Thu Dec 03 00:00:00 EST 2020
Cell swelling, softening and invasion in a three-dimensional breast cancer model.
Nature physics
Han YL,Pegoraro AF,Li H,Li K,Yuan Y,Xu G,Gu Z,Sun J,Hao Y,Gupta SK,Li Y,Tang W,Tang X,Teng L,Fredberg JJ,Guo M
AF-100-15 was used in Cell Culture to investigate the effects of morphological changes seen in breast cancer tissue and its possible role in cancer progression.
Wed Jan 01 00:00:00 EST 2020
Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.
Neuron
Lin L,Zhang M,Stoilov P,Chen L,Zheng S
Wed Sep 23 00:00:00 EDT 2020
Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma.
EMBO molecular medicine
Han M,Wang S,Yang N,Wang X,Zhao W,Saed HS,Daubon T,Huang B,Chen A,Li G,Miletic H,Thorsen F,Bjerkvig R,Li X,Wang J
Thu Jan 09 00:00:00 EST 2020
RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.
The EMBO journal
Spit M,Fenderico N,Jordens I,Radaszkiewicz T,Lindeboom RG,Bugter JM,Cristobal A,Ootes L,van Osch M,Janssen E,Boonekamp KE,Hanakova K,Potesil D,Zdrahal Z,Boj SF,Medema JP,Bryja V,Koo BK,Vermeulen M,Maurice MM
Tue Sep 15 00:00:00 EDT 2020
Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment.
Developmental cell
Bertolini I,Ghosh JC,Kossenkov AV,Mulugu S,Krishn SR,Vaira V,Qin J,Plow EF,Languino LR,Altieri DC
AF-100-15 was used in Cell Culture to investigate epithelium and tumour cell communication with AKT activation.
Mon Oct 26 00:00:00 EDT 2020
Critical roles of phosphoinositides and NF2 in Hippo pathway regulation.
Genes & development
Hong AW,Meng Z,Plouffe SW,Lin Z,Zhang M,Guan KL
AF-100-15 was used in Cell Culture to investigate Hippo activity as regulated by NF2 in cancer.
Wed Apr 01 00:00:00 EDT 2020
A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Smith BA,Balanis NG,Tsai BL,Nguyen K,Cheng MW,Obusan MB,Esedebe FN,Patel SJ,Zhang H,Clark PM,Sisk AE,Said JW,Huang J,Graeber TG,Witte ON,Chin AI,Park JW
Tue Jan 07 00:00:00 EST 2020
Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Sha Z,Goldberg AL
Tue Sep 01 00:00:00 EDT 2020
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America
Choi UY,Lee JJ,Park A,Zhu W,Lee HR,Choi YJ,Yoo JS,Yu C,Feng P,Gao SJ,Chen S,Eoh H,Jung JU
Tue Apr 07 00:00:00 EDT 2020
Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.
Proceedings of the National Academy of Sciences of the United States of America
Leggett SE,Patel M,Valentin TM,Gamboa L,Khoo AS,Williams EK,Franck C,Wong IY
Tue Mar 17 00:00:00 EDT 2020
Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer.
Experimental & molecular medicine
Ryu WJ,Lee JD,Park JC,Cha PH,Cho YH,Kim JY,Sohn JH,Paik S,Choi KY
Fri May 01 00:00:00 EDT 2020
Transplantation of Wnt5a-modified NSCs promotes tissue repair and locomotor functional recovery after spinal cord injury.
Experimental & molecular medicine
Li X,Peng Z,Long L,Lu X,Zhu K,Tuo Y,Chen N,Zhao X,Wang L,Wan Y
Tue Dec 01 00:00:00 EST 2020
miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction.
Aging cell
Hong Y,He H,Jiang G,Zhang H,Tao W,Ding Y,Yuan D,Liu J,Fan H,Lin F,Liang X,Li X,Zhang Y
Wed Apr 01 00:00:00 EDT 2020
Chemotherapy exacerbates ovarian cancer cell migration and cancer stem cell-like characteristics through GLI1.
British journal of cancer
Zhao Y,He M,Cui L,Gao M,Zhang M,Yue F,Shi T,Yang X,Pan Y,Zheng X,Jia Y,Shao D,Li J,He K,Chen L
AF-100-15 was used in Cell Culture to investigate effect of chemotherapeutic treatment of ovarian cancer on its subsequent metastasis.
Fri May 01 00:00:00 EDT 2020
TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness.
Oncogene
Sundqvist A,Vasilaki E,Voytyuk O,Bai Y,Morikawa M,Moustakas A,Miyazono K,Heldin CH,Ten Dijke P,van Dam H
Fri May 01 00:00:00 EDT 2020
Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant.
Oncogene
Veschi V,Mangiapane LR,Nicotra A,Di Franco S,Scavo E,Apuzzo T,Sardina DS,Fiori M,Benfante A,Colorito ML,Cocorullo G,Giuliante F,Cipolla C,Pistone G,Bongiorno MR,Rizzo A,Tate CM,Wu X,Rowlinson S,Stancato LF,Todaro M,De Maria R,Stassi G
Wed Jan 01 00:00:00 EST 2020
Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma.
Oncogene
Grassi ES,Pantazopoulou V,Pietras A
Fri May 01 00:00:00 EDT 2020
TGF-β1 secreted by pancreatic stellate cells promotes stemness and tumourigenicity in pancreatic cancer cells through L1CAM downregulation.
Oncogene
Cave DD,Di Guida M,Costa V,Sevillano M,Ferrante L,Heeschen C,Corona M,Cucciardi A,Lonardo E
Fri May 01 00:00:00 EDT 2020
Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations.
Clinical and translational medicine
Shoemaker LD,McCormick AK,Allen BM,Chang SD
Mon Jun 01 00:00:00 EDT 2020
Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening.
Journal of molecular cell biology
Du Y,Li X,Niu Q,Mo X,Qui M,Ma T,Kuo CJ,Fu H
Sat Aug 01 00:00:00 EDT 2020
Cystic renal-epithelial derived induced pluripotent stem cells from polycystic kidney disease patients.
Stem cells translational medicine
Kenter AT,Rentmeester E,van Riet J,Boers R,Boers J,Ghazvini M,Xavier VJ,van Leenders GJLH,Verhagen PCMS,van Til ME,Eussen B,Losekoot M,de Klein A,Peters DJM,van IJcken WFJ,van de Werken HJG,Zietse R,Hoorn EJ,Jansen G,Gribnau JH
Wed Apr 01 00:00:00 EDT 2020
Retrieval of germinal zone neural stem cells from the cerebrospinal fluid of premature infants with intraventricular hemorrhage.
Stem cells translational medicine
Fernández-Muñoz B,Rosell-Valle C,Ferrari D,Alba-Amador J,Montiel MÁ,Campos-Cuerva R,Lopez-Navas L,Muñoz-Escalona M,Martín-López M,Profico DC,Blanco MF,Giorgetti A,González-Muñoz E,Márquez-Rivas J,Sanchez-Pernaute R
Tue Sep 01 00:00:00 EDT 2020
Grafted human pluripotent stem cell-derived cortical neurons integrate into adult human cortical neural circuitry.
Stem cells translational medicine
Grønning Hansen M,Laterza C,Palma-Tortosa S,Kvist G,Monni E,Tsupykov O,Tornero D,Uoshima N,Soriano J,Bengzon J,Martino G,Skibo G,Lindvall O,Kokaia Z
Sun Nov 01 00:00:00 EDT 2020
TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion.
Molecular oncology
Navarro R,Tapia-Galisteo A,Martín-García L,Tarín C,Corbacho C,Gómez-López G,Sánchez-Tirado E,Campuzano S,González-Cortés A,Yáñez-Sedeño P,Compte M,Álvarez-Vallina L,Sanz L
Thu Oct 01 00:00:00 EDT 2020
The long non-coding RNA DANCR regulates the inflammatory phenotype of breast cancer cells and promotes breast cancer progression via EZH2-dependent suppression of SOCS3 transcription.
Molecular oncology
Zhang KJ,Tan XL,Guo L
Sat Feb 01 00:00:00 EST 2020
Downregulation of STK4 promotes colon cancer invasion/migration through blocking β-catenin degradation.
Molecular oncology
Lin CH,Hsu TI,Chiou PY,Hsiao M,Wang WC,Chen YC,Lin JT,Wang JY,Lin PC,Lin FC,Tseng YK,Cheng HC,Chen CL,Lu PJ
Thu Oct 01 00:00:00 EDT 2020
FRK plays an oncogenic role in non-small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming.
International journal of cancer
Zhang L,Yang Y,Chai L,Bu H,Yang Y,Huang H,Ran J,Zhu Y,Li L,Chen F,Li W
AF-100-15 was used in In vitro experiments to investigate the role of Fyn-related kinase in causing lung cancer in H1299 cells.
Wed Jan 01 00:00:00 EST 2020
ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells.
Genes & diseases
Tirinato L,Pagliari F,Di Franco S,Sogne E,Marafioti MG,Jansen J,Falqui A,Todaro M,Candeloro P,Liberale C,Seco J,Stassi G,Di Fabrizio E
AF-100-15 was used in Tissue/organ culture to investigate the gene modulations following the HG treatment and found out that the healthy cell gene profile was the most affected.
Tue Dec 01 00:00:00 EST 2020
Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells.
Journal of lipid research
Lupien LE,Bloch K,Dehairs J,Traphagen NA,Feng WW,Davis WL,Dennis T,Swinnen JV,Wells WA,Smits NC,Kuemmerle NB,Miller TW,Kinlaw WB
Sat Feb 01 00:00:00 EST 2020
Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells.
Molecular nutrition & food research
Alauddin M,Okumura T,Rajaxavier J,Khozooei S,Pöschel S,Takeda S,Singh Y,Brucker SY,Wallwiener D,Koch A,Salker MS
Wed Apr 01 00:00:00 EDT 2020
EZH2 facilitates BMI1-dependent hepatocarcinogenesis through epigenetically silencing microRNA-200c.
Oncogenesis
Xu L,Lin J,Deng W,Luo W,Huang Y,Liu CQ,Zhang FP,Qin YF,Wong PP,Liu C
Mon Nov 09 00:00:00 EST 2020
FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.
Oncogenesis
Hirano T,Shinsato Y,Tanabe K,Higa N,Kamil M,Kawahara K,Yamamoto M,Minami K,Shimokawa M,Arigami T,Yanagita S,Matushita D,Uenosono Y,Ishigami S,Kijima Y,Maemura K,Kitazono I,Tanimoto A,Furukawa T,Natsugoe S
Thu Feb 06 00:00:00 EST 2020
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability.
Oncogenesis
Liao WC,Liao CK,Tseng TJ,Ho YJ,Chen YR,Lin KH,Lai TJ,Lan CT,Wei KC,Liu CH
Tue Feb 04 00:00:00 EST 2020
CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer.
Oncogenesis
Li Y,Hu H,Wang Y,Fan Y,Yang Y,Guo B,Xie X,Lian J,Jiang B,Han B,Wang Y,Shao C,Gong Y
Thu Feb 13 00:00:00 EST 2020
DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells.
Cancer science
Hu M,Zhao Y,Cao Y,Tang Q,Feng Z,Ni J,Zhou X
Thu Oct 01 00:00:00 EDT 2020
RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells.
Journal of cellular physiology
Fritz AJ,Hong D,Boyd J,Kost J,Finstaad KH,Fitzgerald MP,Hanna S,Abuarqoub AH,Malik M,Bushweller J,Tye C,Ghule P,Gordon J,Frietze S,Zaidi SK,Lian JB,Stein JL,Stein GS
AF-100-15 was used in Cell Culture to many genes previously demonstrated to be regulated by RUNX factors are altered in BCSCs. The RUNX2 interaction network is the top significant pathway altered between CD24-/low and CD24+/high MCF10AT1.
Thu Oct 01 00:00:00 EDT 2020
Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells.
Frontiers in cell and developmental biology
Budkova Z,Sigurdardottir AK,Briem E,Bergthorsson JT,Sigurdsson S,Magnusson MK,Traustadottir GA,Gudjonsson T,Hilmarsdottir B
AF-100-15 was used in Cell Culture to analyze the expression pattern and functional role of non-coding RNAs (ncRNAs) from the DLK1-DIO3 locus in epithelial plasticity of the breast to show that maternally expressed ncRNAs are markers of epithelial-to-mesenchymal transition (EMT) and suggests that maternally expressed gene 3 (MEG3) is a novel regulator of EMT/mesenchymal-to-epithelial transition (MET) in breast tissue.
Mon Sep 28 00:00:00 EDT 2020
Integration of Hydrogel Microparticles With Three-Dimensional Liver Progenitor Cell Spheroids.
Frontiers in bioengineering and biotechnology
Gentile SD,Kourouklis AP,Ryoo H,Underhill GH
AF-100-15 was used in Cell Culture to propose that this liver progenitor cell culture system represents an approach for controlling the presentation of microenvironmental cues internalized within 3D spheroidal aggregate cultures.
Mon Sep 28 00:00:00 EDT 2020
Dipyridamole Enhances the Cytotoxicities of Trametinib against Colon Cancer Cells through Combined Targeting of HMGCS1 and MEK Pathway.
Molecular cancer therapeutics
Zhou S,Xu H,Tang Q,Xia H,Bi F
AF-100-15 was used in In vitro experiments to study cross-talk between the MAPK pathway and mevalonate (MVA) signaling pathway in targeted therapy to identify HMGCS1 as a potential novel biomarker, and the combination of targeting HMGCS1 and MEK as a promising therapeutic strategy for patients with colon cancer.
Wed Jan 01 00:00:00 EST 2020
cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer.
Stem cells (Dayton, Ohio)
He Y,Xiao M,Fu H,Chen L,Qi L,Liu D,Guo P,Chen L,Luo Y,Xiao H,Zhang N,Guo H
Wed Apr 01 00:00:00 EDT 2020
The Sca-1+ and Sca-1- mouse prostatic luminal cell lineages are independently sustained.
Stem cells (Dayton, Ohio)
Kwon OJ,Choi JM,Zhang L,Jia D,Li Z,Zhang Y,Jung SY,Creighton CJ,Xin L
Sun Nov 01 00:00:00 EDT 2020
Implantation of the clinical-grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease.
Stem cells (Dayton, Ohio)
Yoon Y,Kim HS,Jeon I,Noh JE,Park HJ,Lee S,Park IH,Stevanato L,Hicks C,Corteling R,Barker RA,Sinden JD,Song J
Sat Aug 01 00:00:00 EDT 2020
Glioma stem cell (GSC)-derived autoschizis-like products confer GSC niche properties involving M1-like tumor-associated macrophages.
Stem cells (Dayton, Ohio)
Tabu K,Liu W,Kosaku A,Terashima K,Murota Y,Aimaitijiang A,Nobuhisa I,Hide T,Taga T
Sat Aug 01 00:00:00 EDT 2020
SPARC promotes self-renewal of limbal epithelial stem cells and ocular surface restoration through JNK and p38-MAPK signaling pathways.
Stem cells (Dayton, Ohio)
Zhu J,Wang LY,Li CY,Wu JY,Zhang YT,Pang KP,Wei Y,Du LQ,Liu M,Wu XY
Wed Jan 01 00:00:00 EST 2020
Extracellular vesicles transmit epithelial growth factor activity in the intestinal stem cell niche.
Stem cells (Dayton, Ohio)
Oszvald Á,Szvicsek Z,Sándor GO,Kelemen A,Soós AÁ,Pálóczi K,Bursics A,Dede K,Tölgyes T,Buzás EI,Zeöld A,Wiener Z
Sat Feb 01 00:00:00 EST 2020
Extracellular vesicles transmit epithelial growth factor activity in the intestinal stem cell niche.
Stem cells (Dayton, Ohio)
Oszvald Á,Szvicsek Z,Sándor GO,Kelemen A,Soós AÁ,Pálóczi K,Bursics A,Dede K,Tölgyes T,Buzás EI,Zeöld A,Wiener Z
Sat Feb 01 00:00:00 EST 2020
Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ghosh R,Wood-Kaczmar A,Dobson L,Smith EJ,Sirinathsinghji EC,Kriston-Vizi J,Hargreaves IP,Heaton R,Herrmann F,Abramov AY,Lam AJ,Heales SJ,Ketteler R,Bates GP,Andre R,Tabrizi SJ
Mon Jun 01 00:00:00 EDT 2020
Basal-like and classical cells coexist in pancreatic cancer revealed by single-cell analysis on biopsy-derived pancreatic cancer organoids from the classical subtype.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Juiz N,Elkaoutari A,Bigonnet M,Gayet O,Roques J,Nicolle R,Iovanna J,Dusetti N
Tue Sep 01 00:00:00 EDT 2020
Myeloid-derived suppressor cells promote epithelial ovarian cancer cell stemness by inducing the CSF2/p-STAT3 signalling pathway.
The FEBS journal
Li X,Wang J,Wu W,Gao H,Liu N,Zhan G,Li L,Han L,Guo X
Tue Dec 01 00:00:00 EST 2020
Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids.
The FEBS journal
Fernández-Barral A,Costales-Carrera A,Buira SP,Jung P,Ferrer-Mayorga G,Larriba MJ,Bustamante-Madrid P,Domínguez O,Real FX,Guerra-Pastrián L,Lafarga M,García-Olmo D,Cantero R,Del Peso L,Batlle E,Rojo F,Muñoz A,Barbáchano A
Wed Jan 01 00:00:00 EST 2020
LncRNA SPRY4-IT1 regulates breast cancer cell stemness through competitively binding miR-6882-3p with TCF7L2.
Journal of cellular and molecular medicine
Song X,Zhang X,Wang X,Chen L,Jiang L,Zheng A,Zhang M,Zhao L,Wei M
Wed Jan 01 00:00:00 EST 2020
Differential response to hepatic differentiation stimuli of amniotic epithelial cells isolated from four regions of the amniotic membrane.
Journal of cellular and molecular medicine
Passaretta F,Bosco D,Centurione L,Centurione MA,Marongiu F,Di Pietro R
Wed Apr 01 00:00:00 EDT 2020
Platelet sonicates activate hair follicle stem cells and mediate enhanced hair follicle regeneration.
Journal of cellular and molecular medicine
Zhu M,Kong D,Tian R,Pang M,Mo M,Chen Y,Yang G,Liu Cheng H,Lei X,Fang K,Cheng B,Wu Y
Wed Jan 01 00:00:00 EST 2020
Regulation of the EGFR/ErbB signalling by clathrin in response to various ligands in hepatocellular carcinoma cell lines.
Journal of cellular and molecular medicine
Liu Y,Calmel C,Desbois-Mouthon C,Sobczak-Thépot J,Karaiskou A,Praz F
Wed Jul 01 00:00:00 EDT 2020
Odontogenesis and neuronal differentiation characteristics of periodontal ligament stem cells from beagle dog.
Journal of cellular and molecular medicine
Li X,Liao D,Sun G,Chu H
Fri May 01 00:00:00 EDT 2020
Endogenous thrombopoietin promotes non-small-cell lung carcinoma cell proliferation and migration by regulating EGFR signalling.
Journal of cellular and molecular medicine
Zou Z,Fan X,Liu Y,Sun Y,Zhang X,Sun G,Li X,Xu S
Mon Jun 01 00:00:00 EDT 2020
Generating low immunogenic pig pancreatic islet cell clusters for xenotransplantation.
Journal of cellular and molecular medicine
Carvalho Oliveira M,Valdivia E,Verboom M,Yuzefovych Y,Sake HJ,Pogozhykh O,Niemann H,Schwinzer R,Petersen B,Seissler J,Blasczyk R,Figueiredo C
Fri May 01 00:00:00 EDT 2020
Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors.
American journal of physiology. Cell physiology
Sepehrimanesh M,Ding B
Thu Oct 01 00:00:00 EDT 2020
Reduced PAX2 expression in murine fallopian tube cells enhances estrogen receptor signaling.
Carcinogenesis
Colina JA,Varughese P,Karthikeyan S,Salvi A,Modi DA,Burdette JE
AF-100-15 was used in Cell Culture to develop a paired box 2 (PAX2)-deficient murine cell line to model secretory cell outgrowth (SCOUT) and investigate the role of PAX2 loss in the etiology of high-grade serous ovarian cancer (HGSOC).
Fri Jul 10 00:00:00 EDT 2020
A comparative analysis of human adult testicular cells expressing stem Leydig cell markers in the interstitium, vasculature, and peritubular layer.
Andrology
Eliveld J,van Daalen SKM,de Winter-Korver CM,van der Veen F,Repping S,Teerds K,van Pelt AMM
Tue Sep 01 00:00:00 EDT 2020
Exosomes derived from chemically induced human hepatic progenitors inhibit oxidative stress induced cell death.
Biotechnology and bioengineering
Hyung S,Jeong J,Shin K,Kim JY,Yim JH,Yu CJ,Jung HS,Hwang KG,Choi D,Hong JW
Tue Sep 01 00:00:00 EDT 2020
Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering.
Journal of biomedical materials research. Part B, Applied biomaterials
Reid JA,Callanan A
Wed Apr 01 00:00:00 EDT 2020
Arginine Supply Impacts the Expression of Candidate microRNA Controlling Milk Casein Yield in Bovine Mammary Tissue.
Animals : an open access journal from MDPI
Zhang X,Wang Y,Wang M,Zhou G,Chen L,Ding L,Bu D,Loor J
AF-100-15 was used in Cell Culture to reveal that arginine might partly influence casein yield by altering the expression of 6 miRNAs.
Tue May 05 00:00:00 EDT 2020
Genomic characteristics and drug screening among organoids derived from non-small cell lung cancer patients.
Thoracic cancer
Chen JH,Chu XP,Zhang JT,Nie Q,Tang WF,Su J,Yan HH,Zheng HP,Chen ZX,Chen X,Song MM,Yi X,Li PS,Guan YF,Li G,Deng CX,Rosell R,Wu YL,Zhong WZ
Sat Aug 01 00:00:00 EDT 2020
A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells.
Oncology letters
Qi SG,Quan LQ,Cui XY,Li HM,Zhao XD,Li RT
AF-100-15 was used in Cell Culture to study the antitumor activity of rupesin E in glioma stem cells (GSCs).
Sat Feb 01 00:00:00 EST 2020
The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs.
Nature communications
Zorzan I,Pellegrini M,Arboit M,Incarnato D,Maldotti M,Forcato M,Tagliazucchi GM,Carbognin E,Montagner M,Oliviero S,Martello G
Tue May 12 00:00:00 EDT 2020
EMT-Induced Cell-Mechanical Changes Enhance Mitotic Rounding Strength.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Hosseini K,Taubenberger A,Werner C,Fischer-Friedrich E
Thu Oct 01 00:00:00 EDT 2020
Direct On-Chip Differentiation of Intestinal Tubules from Induced Pluripotent Stem Cells.
International journal of molecular sciences
Naumovska E,Aalderink G,Wong Valencia C,Kosim K,Nicolas A,Brown S,Vulto P,Erdmann KS,Kurek D
AF-100-15 was used in Cell Culture to study the direct differentiation of induced pluripotent stem cells.
Tue Jul 14 00:00:00 EDT 2020
Growth factors-based beneficial effects of platelet lysate on umbilical cord-derived stem cells and their synergistic use in osteoarthritis treatment.
Cell death & disease
Yan L,Zhou L,Yan B,Zhang L,Du W,Liu F,Yuan Q,Tong P,Shan L,Efferth T
Wed Oct 14 00:00:00 EDT 2020
Oral Administration of Bovine and Porcine Milk Exosome Alter miRNAs Profiles in Piglet Serum.
Scientific reports
Lin D,Chen T,Xie M,Li M,Zeng B,Sun R,Zhu Y,Ye D,Wu J,Sun J,Xi Q,Jiang Q,Zhang Y
Fri Apr 24 00:00:00 EDT 2020
The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells.
Cancers
Kang DY,Sp N,Jo ES,Rugamba A,Hong DY,Lee HG,Yoo JS,Liu Q,Jang KJ,Yang YM
AF-100-15 was used in Western Blotting to gallic acid was used to study the down-regulation of PD-L1 in non-small-cell lung cancer cells.
Thu Mar 19 00:00:00 EDT 2020
Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.
Nature communications
Tedeschi A,Almagro J,Renshaw MJ,Messal HA,Behrens A,Petronczki M
Wed Apr 08 00:00:00 EDT 2020
Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells.
Scientific reports
Constantinou C,Miranda AMA,Chaves P,Bellahcene M,Massaia A,Cheng K,Samari S,Rothery SM,Chandler AM,Schwarz RP,Harding SE,Punjabi P,Schneider MD,Noseda M
Mon Aug 03 00:00:00 EDT 2020
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Nature communications
Grinat J,Heuberger J,Vidal RO,Goveas N,Kosel F,Berenguer-Llergo A,Kranz A,Wulf-Goldenberg A,Behrens D,Melcher B,Sauer S,Vieth M,Batlle E,Stewart AF,Birchmeier W
Mon Dec 21 00:00:00 EST 2020
A Comparative Analysis of Multipotent Mesenchymal Stromal Cells derived from Different Sources, with a Focus on Neuroregenerative Potential.
Scientific reports
Petrenko Y,Vackova I,Kekulova K,Chudickova M,Koci Z,Turnovcova K,Kupcova Skalnikova H,Vodicka P,Kubinova S
Mon Mar 09 00:00:00 EDT 2020
A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.
Cell reports
Johansson P,Krona C,Kundu S,Doroszko M,Baskaran S,Schmidt L,Vinel C,Almstedt E,Elgendy R,Elfineh L,Gallant C,Lundsten S,Ferrer Gago FJ,Hakkarainen A,Sipilä P,Häggblad M,Martens U,Lundgren B,Frigault MM,Lane DP,Swartling FJ,Uhrbom L,Nestor M,Marino S,Nelander S
AF-100-15 was used in Cell Culture to report significance of a functionally profiled biobank as a precise, integrated, pharmogenomic analysis resosurces to discover and study GBM therapeutics approaches.
Tue Jul 14 00:00:00 EDT 2020
Drug Repositioning Screen on a New Primary Cell Line Identifies Potent Therapeutics for Glioblastoma.
Frontiers in neuroscience
Senbabaoglu F,Aksu AC,Cingoz A,Seker-Polat F,Borklu-Yucel E,Solaroglu İ,Bagci-Onder T
AF-100-15 was used in Cell Culture to provide a new primary cell line model that can be suitable for both in vitro and in vivo studies and suggests that Topotecan can offer promise as a therapeutic approach for glioblastoma.
Tue Jan 05 00:00:00 EST 2021
Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis.
Nature communications
Oulès B,Philippeos C,Segal J,Tihy M,Vietri Rudan M,Cujba AM,Grange PA,Quist S,Natsuga K,Deschamps L,Dupin N,Donati G,Watt FM
Tue Oct 20 00:00:00 EDT 2020
Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway.
Molecular systems biology
Gillies TE,Pargett M,Silva JM,Teragawa CK,McCormick F,Albeck JG
Thu Oct 01 00:00:00 EDT 2020
Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease.
Scientific reports
Verstegen MMA,Roos FJM,Burka K,Gehart H,Jager M,de Wolf M,Bijvelds MJC,de Jonge HR,Ardisasmita AI,van Huizen NA,Roest HP,de Jonge J,Koch M,Pampaloni F,Fuchs SA,Schene IF,Luider TM,van der Doef HPJ,Bodewes FAJA,de Kleine RHJ,Spee B,Kremers GJ,Clevers H,IJzermans JNM,Cuppen E,van der Laan LJW
Mon Dec 14 00:00:00 EST 2020
2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche.
Communications biology
Koike N,Kota R,Naito Y,Hayakawa N,Matsuura T,Hishiki T,Onishi N,Fukada J,Suematsu M,Shigematsu N,Saya H,Sampetrean O
Mon Aug 17 00:00:00 EDT 2020
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
Cell death discovery
Koch K,Hartmann R,Tsiampali J,Uhlmann C,Nickel AC,He X,Kamp MA,Sabel M,Barker RA,Steiger HJ,Hänggi D,Willbold D,Maciaczyk J,Kahlert UD
Tue Sep 26 00:00:00 EDT 2023
Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation.
Communications biology
Schwartz M,Portugez AS,Attia BZ,Tannenbaum M,Cohen L,Loza O,Chase E,Turman Y,Kaplan T,Salah Z,Hakim O
Wed Nov 25 00:00:00 EST 2020
Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy.
Communications biology
Rebelo de Almeida C,Mendes RV,Pezzarossa A,Gago J,Carvalho C,Alves A,Nunes V,Brito MJ,Cardoso MJ,Ribeiro J,Cardoso F,Ferreira MG,Fior R
Wed Jun 10 00:00:00 EDT 2020
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Nature communications
Calandrini C,Schutgens F,Oka R,Margaritis T,Candelli T,Mathijsen L,Ammerlaan C,van Ineveld RL,Derakhshan S,de Haan S,Dolman E,Lijnzaad P,Custers L,Begthel H,Kerstens HHD,Visser LL,Rookmaaker M,Verhaar M,Tytgat GAM,Kemmeren P,de Krijger RR,Al-Saadi R,Pritchard-Jones K,Kool M,Rios AC,van den Heuvel-Eibrink MM,Molenaar JJ,van Boxtel R,Holstege FCP,Clevers H,Drost J
Wed Mar 11 00:00:00 EDT 2020
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development.
Nature communications
Shankar S,Tien JC,Siebenaler RF,Chugh S,Dommeti VL,Zelenka-Wang S,Wang XM,Apel IJ,Waninger J,Eyunni S,Xu A,Mody M,Goodrum A,Zhang Y,Tesmer JJ,Mannan R,Cao X,Vats P,Pitchiaya S,Ellison SJ,Shi J,Kumar-Sinha C,Crawford HC,Chinnaiyan AM
Thu Jun 04 00:00:00 EDT 2020
PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor.
Cell death & disease
Liu F,Wu X,Qian Y,Jiang X,Wang Y,Gao J
Mon Jun 08 00:00:00 EDT 2020
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways.
Nature communications
Pattwell SS,Arora S,Cimino PJ,Ozawa T,Szulzewsky F,Hoellerbauer P,Bonifert T,Hoffstrom BG,Boiani NE,Bolouri H,Correnti CE,Oldrini B,Silber JR,Squatrito M,Paddison PJ,Holland EC
Fri Jun 12 00:00:00 EDT 2020
Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1-JNK axis.
The Journal of biological chemistry
Suzuki S,Okada M,Sanomachi T,Togashi K,Seino S,Sato A,Yamamoto M,Kitanaka C
Fri Dec 25 00:00:00 EST 2020
Modelling human CNS injury with human neural stem cells in 2- and 3-Dimensional cultures.
Scientific reports
Vagaska B,Gillham O,Ferretti P
Wed Apr 22 00:00:00 EDT 2020
Establishment of A Reversibly Inducible Porcine Granulosa Cell Line.
Cells
Bai Y,Zhu C,Feng M,Pan B,Zhang S,Zhan X,Chen H,Wang B,Li J
AF-100-15 was used in Cell Culture to proliferate cells porcine granulosa cells with reversible proliferation using tetracycline inducible 3G system.
Wed Jan 08 00:00:00 EST 2020
JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both In Vitro and In Vivo.
ACS infectious diseases
Li Z,Xu J,Lang Y,Fan X,Kuo L,D'Brant L,Hu S,Samrat SK,Trudeau N,Tharappel AM,Rugenstein N,Koetzner CA,Zhang J,Chen H,Kramer LD,Butler D,Zhang QY,Zhou J,Li H
AF-100-15 was used in Cell Culture to investigate potential therapeutic targeting of Zika virus via proteins NS3 and NS2B.
Fri Oct 09 00:00:00 EDT 2020
Transient microglial absence assists postmigratory cortical neurons in proper differentiation.
Nature communications
Hattori Y,Naito Y,Tsugawa Y,Nonaka S,Wake H,Nagasawa T,Kawaguchi A,Miyata T
Thu Apr 02 00:00:00 EDT 2020
Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Tian A,Kang B,Li B,Qiu B,Jiang W,Shao F,Gao Q,Liu R,Cai C,Jing R,Wang W,Chen P,Liang Q,Bao L,Man J,Wang Y,Shi Y,Li J,Yang M,Wang L,Zhang J,Hippenmeyer S,Zhu J,Bian X,Wang YJ,Liu C
Sun Nov 01 00:00:00 EDT 2020
LncRNA NEAT1 remodels chromatin to promote the 5-Fu resistance by maintaining colorectal cancer stemness.
Cell death & disease
Zhu Y,Hu H,Yuan Z,Zhang Q,Xiong H,Hu Z,Wu H,Huang R,Wang G,Tang Q
Mon Nov 09 00:00:00 EST 2020
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI.
The Journal of biological chemistry
Lauer V,Grampp S,Platt J,Lafleur V,Lombardi O,Choudhry H,Kranz F,Hartmann A,Wullich B,Yamamoto A,Coleman ML,Ratcliffe PJ,Mole DR,Schödel J
Fri Mar 27 00:00:00 EDT 2020
Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype.
Nature communications
Wu Y,Fletcher M,Gu Z,Wang Q,Costa B,Bertoni A,Man KH,Schlotter M,Felsberg J,Mangei J,Barbus M,Gaupel AC,Wang W,Weiss T,Eils R,Weller M,Liu H,Reifenberger G,Korshunov A,Angel P,Lichter P,Herrmann C,Radlwimmer B
Fri Dec 18 00:00:00 EST 2020
Glucocorticoid-dependent transcription in skin requires epidermal expression of the glucocorticoid receptor and is modulated by the mineralocorticoid receptor.
Scientific reports
Sevilla LM,Bigas J,Chiner-Oms Á,Comas I,Sentandreu V,Pérez P
Tue Nov 03 00:00:00 EST 2020
Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin.
Nature communications
Dyring-Andersen B,Løvendorf MB,Coscia F,Santos A,Møller LBP,Colaço AR,Niu L,Bzorek M,Doll S,Andersen JL,Clark RA,Skov L,Teunissen MBM,Mann M
Thu Nov 05 00:00:00 EST 2020
Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells.
Cell death & disease
Woznicki JA,Flood P,Bustamante-Garrido M,Stamou P,Moloney G,Fanning A,Zulquernain SA,McCarthy J,Shanahan F,Melgar S,Nally K
Mon Jan 27 00:00:00 EST 2020
The mutational impact of culturing human pluripotent and adult stem cells.
Nature communications
Kuijk E,Jager M,van der Roest B,Locati MD,Van Hoeck A,Korzelius J,Janssen R,Besselink N,Boymans S,van Boxtel R,Cuppen E
Tue May 19 00:00:00 EDT 2020
C/EBPα is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition.
Nature communications
Lourenço AR,Roukens MG,Seinstra D,Frederiks CL,Pals CE,Vervoort SJ,Margarido AS,van Rheenen J,Coffer PJ
Fri Feb 07 00:00:00 EST 2020
Oligomeric amyloid-β induces early and widespread changes to the proteome in human iPSC-derived neurons.
Scientific reports
Sackmann C,Hallbeck M
Thu Apr 16 00:00:00 EDT 2020
A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM-/CD133- nonStem Cells into EpCAM+/CD133+ Liver Cancer Stem Cells in HCC Cell Line HuH7.
Cells
Karagonlar ZF,Akbari S,Karabicici M,Sahin E,Avci ST,Ersoy N,Ates KE,Balli T,Karacicek B,Kaplan KN,Celiker C,Atabey N,Erdal E
AF-100-15 was used in Cell Culture to study how KLF4 as a transcription factor that can induce a cancer stem cell (CSC)-like phenotype in non-CSCs through upregulating the EpCAM and E-CAD expression.
Tue May 12 00:00:00 EDT 2020
Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer.
International journal of molecular sciences
Li X,Strietz J,Bleilevens A,Stickeler E,Maurer J
AF-100-15 was used in Cell Culture to indicate that chemotherapeutic stress enhanced sphere forming capacity of BCSCs, and changed cell morphology and EMT-related gene expression at the mRNA level, whereas the migratory capacity was unaffected. Six miRNAs were identified as potential regulators in this process.
Wed Jan 08 00:00:00 EST 2020
A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior.
Nature communications
Schiano Lomoriello I,Giangreco G,Iavarone C,Tordonato C,Caldieri G,Serio G,Confalonieri S,Freddi S,Bianchi F,Pirroni S,Bertalot G,Viale G,Disalvatore D,Tosoni D,Malabarba MG,Disanza A,Scita G,Pece S,Pilcher BK,Vecchi M,Sigismund S,Di Fiore PP
Mon Jun 15 00:00:00 EDT 2020
Mechano-modulatory synthetic niches for liver organoid derivation.
Nature communications
Sorrentino G,Rezakhani S,Yildiz E,Nuciforo S,Heim MH,Lutolf MP,Schoonjans K
Fri Jul 10 00:00:00 EDT 2020
Modulating electrospun polycaprolactone scaffold morphology and composition to alter endothelial cell proliferation and angiogenic gene response.
PloS one
Reid JA,McDonald A,Callanan A
Tue Dec 08 00:00:00 EST 2020
Association between glioblastoma cell-derived vessels and poor prognosis of the patients.
Cancer communications (London, England)
Mei X,Chen YS,Zhang QP,Chen FR,Xi SY,Long YK,Zhang J,Cai HP,Ke C,Wang J,Chen ZP
Fri May 01 00:00:00 EDT 2020
Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment.
Cell death & disease
Kant S,Kesarwani P,Prabhu A,Graham SF,Buelow KL,Nakano I,Chinnaiyan P
Mon Apr 20 00:00:00 EDT 2020
A simple and highly efficient method for multi-allelic CRISPR-Cas9 editing in primary cell cultures.
Cancer reports (Hoboken, N.J.)
Hoellerbauer P,Kufeld M,Arora S,Wu HJ,Feldman HM,Paddison PJ
Thu Oct 01 00:00:00 EDT 2020
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Cell death & disease
Jia Z,Zhang Y,Yan A,Wang M,Han Q,Wang K,Wang J,Qiao C,Pan Z,Chen C,Hu D,Ding X
Thu Aug 20 00:00:00 EDT 2020
Nucleosome destabilization by nuclear non-coding RNAs.
Communications biology
Fujita R,Yamamoto T,Arimura Y,Fujiwara S,Tachiwana H,Ichikawa Y,Sakata Y,Yang L,Maruyama R,Hamada M,Nakao M,Saitoh N,Kurumizaka H
Tue Feb 11 00:00:00 EST 2020
MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer.
Cell death & disease
Wu H,Liu B,Chen Z,Li G,Zhang Z
Thu Apr 16 00:00:00 EDT 2020
Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth.
Scientific reports
Leventoux N,Augustus M,Azar S,Riquier S,Villemin JP,Guelfi S,Falha L,Bauchet L,Gozé C,Ritchie W,Commes T,Duffau H,Rigau V,Hugnot JP
Thu Mar 26 00:00:00 EDT 2020
A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2).
The Journal of biological chemistry
Hartman Z,Geldenhuys WJ,Agazie YM
Fri Mar 13 00:00:00 EDT 2020
SOX9-activated FARSA-AS1 predetermines cell growth, stemness, and metastasis in colorectal cancer through upregulating FARSA and SOX9.
Cell death & disease
Zhou T,Wu L,Ma N,Tang F,Yu Z,Jiang Z,Li Y,Zong Z,Hu K
Mon Dec 14 00:00:00 EST 2020
Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma.
Brain communications
Merisaari J,Denisova OV,Doroszko M,Le Joncour V,Johansson P,Leenders WPJ,Kastrinsky DB,Zaware N,Narla G,Laakkonen P,Nelander S,Ohlmeyer M,Westermarck J
AF-100-15 was used in Cell Culture to propose that, based on a demonstrated role for protein phosphatase 2A inhibition in glioblastoma cell drug resistance, small molecule activators of protein phosphatase 2A may prove to be beneficial in future glioblastoma combination therapies.
Mon Sep 28 00:00:00 EDT 2020
Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD.
Molecular neurodegeneration
Andrade NS,Ramic M,Esanov R,Liu W,Rybin MJ,Gaidosh G,Abdallah A,Del'Olio S,Huff TC,Chee NT,Anatha S,Gendron TF,Wahlestedt C,Zhang Y,Benatar M,Mueller C,Zeier Z
AF-100-15 was used in Cell Culture to study the efficiency of specific repair pathways using DNA double strand break (DSB) repair assays.
Mon Feb 24 00:00:00 EST 2020
Genetically Engineered Mouse Model of Brainstem High-Grade Glioma.
STAR protocols
Nunez FM,Gauss JC,Mendez FM,Haase S,Lowenstein PR,Castro MG
AF-100-15 was used in Cell Culture to study the effect of these mutations in tumor progression and response to treatments can be studied within a relevant in vivo context.
Fri Dec 18 00:00:00 EST 2020
Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform.
Nature communications
Kutys ML,Polacheck WJ,Welch MK,Gagnon KA,Koorman T,Kim S,Li L,McClatchey AI,Chen CS
Mon Jul 06 00:00:00 EDT 2020
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
Scientific reports
Alt EU,Wörner PM,Pfnür A,Ochoa JE,Schächtele DJ,Barabadi Z,Lang LM,Srivastav S,Burow ME,Chandrasekar B,Izadpanah R
Mon Jun 01 00:00:00 EDT 2020
Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6.
Cell death & disease
Zhang Y,Guo L,Han S,Chen L,Li C,Zhang Z,Hong Y,Zhang X,Zhou X,Jiang D,Liang X,Qiu J,Zhang J,Li X,Zhong S,Liao C,Yan B,Tse HF,Lian Q
Tue Dec 15 00:00:00 EST 2020
Unique Cancer Migratory Behaviors in Confined Spaces of Microgroove Topography with Acute Wall Angles.
Scientific reports
Yaginuma T,Kushiro K,Takai M
Thu Apr 09 00:00:00 EDT 2020
Endothelial Autophagy: an Effective Target for Radiation-induced Cerebral Capillary Damage.
Scientific reports
Ai X,Ye Z,Yao Y,Xiao J,You C,Xu J,Huang X,Zhong J,Fan M,Song X,Shi H,Zhang D,Zhao C
Fri Jan 17 00:00:00 EST 2020
SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop.
Cell death & disease
An Y,Wang B,Wang X,Dong G,Jia J,Yang Q
Wed Feb 12 00:00:00 EST 2020
Label-Free Imaging of Cholesterol Assemblies Reveals Hidden Nanomechanics of Breast Cancer Cells.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dumitru AC,Mohammed D,Maja M,Yang J,Verstraeten S,Del Campo A,Mingeot-Leclercq MP,Tyteca D,Alsteens D
Sun Nov 01 00:00:00 EDT 2020
Modulation of hepatitis B virus infection by epidermal growth factor secreted from liver sinusoidal endothelial cells.
Scientific reports
Chen SW,Himeno M,Koui Y,Sugiyama M,Nishitsuji H,Mizokami M,Shimotohno K,Miyajima A,Kido T
Tue Sep 01 00:00:00 EDT 2020
Hyaluronan regulates synapse formation and function in developing neural networks.
Scientific reports
Wilson E,Knudson W,Newell-Litwa K
Mon Oct 05 00:00:00 EDT 2020
Development of a human primary gut-on-a-chip to model inflammatory processes.
Scientific reports
Beaurivage C,Kanapeckaite A,Loomans C,Erdmann KS,Stallen J,Janssen RAJ
Tue Dec 08 00:00:00 EST 2020
Stem cell characteristics promote aggressiveness of diffuse large B-cell lymphoma.
Scientific reports
Chang KC,Chen RY,Wang YC,Hung LY,Medeiros LJ,Chen YP,Chen TY,Yang JC,Chiang PM
Mon Dec 07 00:00:00 EST 2020
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits.
Cell stem cell
Bowers M,Liang T,Gonzalez-Bohorquez D,Zocher S,Jaeger BN,Kovacs WJ,Röhrl C,Cramb KML,Winterer J,Kruse M,Dimitrieva S,Overall RW,Wegleiter T,Najmabadi H,Semenkovich CF,Kempermann G,Földy C,Jessberger S
AF-100-15 was used in Cell Culture to investigate lipid metabolism and cognitive function in neural stem/progenitor cells and human embryonic stem cells.
Thu Jul 02 00:00:00 EDT 2020
Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells.
Current protocols in immunology
Pleguezuelos-Manzano C,Puschhof J,van den Brink S,Geurts V,Beumer J,Clevers H
AF-100-15 was used in Cell Culture to provide a basic guide to establishment and maintenance of human intestinal organoids derived from small intestine and colon biopsies and provide an overview of several downstream applications of human intestinal organoids.
Tue Sep 01 00:00:00 EDT 2020
Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery.
Neuroscience letters
Soubannier V,Maussion G,Chaineau M,Sigutova V,Rouleau G,Durcan TM,Stifani S
AF-100-15 was used in Cell Culture to investigate the use of human induced pluripotent stem cells-derived astrocytes in studying neurological diseases.
Mon Jul 13 00:00:00 EDT 2020
SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells.
eLife
Oliemuller E,Newman R,Tsang SM,Foo S,Muirhead G,Noor F,Haider S,Aurrekoetxea-Rodríguez I,Vivanco MD,Howard BA
AF-100-15 was used in Cell Culture to find that that SOX11+DCIS tumour cells metastasize to brain and bone at greater frequency and to lungs at lower frequency compared to cells with lower SOX11 levels.
Thu Sep 10 00:00:00 EDT 2020
Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity.
Nature communications
Manzella G,Schreck LD,Breunis WB,Molenaar J,Merks H,Barr FG,Sun W,Römmele M,Zhang L,Tchinda J,Ngo QA,Bode P,Delattre O,Surdez D,Rekhi B,Niggli FK,Schäfer BW,Wachtel M
Tue Sep 15 00:00:00 EDT 2020
Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche.
Scientific reports
Bassi G,Panseri S,Dozio SM,Sandri M,Campodoni E,Dapporto M,Sprio S,Tampieri A,Montesi M
Fri Dec 18 00:00:00 EST 2020
A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA.
Nature communications
de Jong OG,Murphy DE,Mäger I,Willms E,Garcia-Guerra A,Gitz-Francois JJ,Lefferts J,Gupta D,Steenbeek SC,van Rheenen J,El Andaloussi S,Schiffelers RM,Wood MJA,Vader P
Fri Feb 28 00:00:00 EST 2020
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
Nature communications
Chang KC,Diermeier SD,Yu AT,Brine LD,Russo S,Bhatia S,Alsudani H,Kostroff K,Bhuiya T,Brogi E,Pappin DJ,Bennett CF,Rigo F,Spector DL
Tue Dec 22 00:00:00 EST 2020
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds.
Nature communications
Campinoti S,Gjinovci A,Ragazzini R,Zanieri L,Ariza-McNaughton L,Catucci M,Boeing S,Park JE,Hutchinson JC,Muñoz-Ruiz M,Manti PG,Vozza G,Villa CE,Phylactopoulos DE,Maurer C,Testa G,Stauss HJ,Teichmann SA,Sebire NJ,Hayday AC,Bonnet D,Bonfanti P
Fri Dec 11 00:00:00 EST 2020
microRNA-181c-5p promotes the formation of insulin-producing cells from human induced pluripotent stem cells by targeting smad7 and TGIF2.
Cell death & disease
Li N,Jiang D,He Q,He F,Li Y,Deng C,Li F
Mon Jun 15 00:00:00 EDT 2020
Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice.
Nature communications
Sun J,Huang Y,Gong J,Wang J,Fan Y,Cai J,Wang Y,Qiu Y,Wei Y,Xiong C,Chen J,Wang B,Ma Y,Huang L,Chen X,Zheng S,Huang W,Ke Q,Wang T,Li X,Zhang W,Xiang AP,Li W
Thu Oct 15 00:00:00 EDT 2020
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation.
Nature communications
Cho YH,Ro EJ,Yoon JS,Mizutani T,Kang DW,Park JC,Il Kim T,Clevers H,Choi KY
Wed Oct 21 00:00:00 EDT 2020
Long noncoding RNA FOXD2-AS1 enhances chemotherapeutic resistance of laryngeal squamous cell carcinoma via STAT3 activation.
Cell death & disease
Li R,Chen S,Zhan J,Li X,Liu W,Sheng X,Lu Z,Zhong R,Chen L,Luo X,Hu Y,Ouyang Y,Liu T,Zhang Q,Zhang S
Mon Jan 20 00:00:00 EST 2020
Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma.
Scientific reports
Shono K,Yamaguchi I,Mizobuchi Y,Kagusa H,Sumi A,Fujihara T,Nakajima K,Kitazato KT,Matsuzaki K,Saya H,Takagi Y
Thu Sep 17 00:00:00 EDT 2020
A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models.
Journal of experimental neurology
Biery MC,Noll A,Myers C,Morris SM,Winter CA,Pakiam F,Cole BL,Browd SR,Olson JM,Vitanza NA
AF-100-15 was used in Cell Culture to provide a protocol for the generation of treatment-naïve biopsy-derived diffuse intrinsic pontine glioma (DIPG)/DMG models.
Tue Dec 01 00:00:00 EST 2020
Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in vitro and in vivo.
Emerging microbes & infections
Li Z,Lang Y,Sakamuru S,Samrat S,Trudeau N,Kuo L,Rugenstein N,Tharappel A,D'Brant L,Koetzner CA,Hu S,Zhang J,Huang R,Kramer LD,Butler D,Xia M,Li H
AF-100-15 was used in Cell Culture to conclude that methylene blue represents a promising and easily developed therapy for management of infections by ZIKV and other flaviviruses.
Tue Dec 01 00:00:00 EST 2020
Raloxifene prevents stress granule dissolution, impairs translational control and promotes cell death during hypoxia in glioblastoma cells.
Cell death & disease
Attwood KM,Robichaud A,Westhaver LP,Castle EL,Brandman DM,Balgi AD,Roberge M,Colp P,Croul S,Kim I,McCormick C,Corcoran JA,Weeks A
Tue Nov 17 00:00:00 EST 2020
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency.
Nature communications
Huang Y,Zhang H,Wang L,Tang C,Qin X,Wu X,Pan M,Tang Y,Yang Z,Babarinde IA,Lin R,Ji G,Lai Y,Xu X,Su J,Wen X,Satoh T,Ahmed T,Malik V,Ward C,Volpe G,Guo L,Chen J,Sun L,Li Y,Huang X,Bao X,Gao F,Liu B,Zheng H,Jauch R,Lai L,Pan G,Chen J,Testa G,Akira S,Hu J,Pei D,Hutchins AP,Esteban MA,Qin B
Thu Oct 08 00:00:00 EDT 2020
BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer.
Cell death & disease
Pandya V,Githaka JM,Patel N,Veldhoen R,Hugh J,Damaraju S,McMullen T,Mackey J,Goping IS
Thu Jun 11 00:00:00 EDT 2020
Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence.
Communications biology
de Lucia C,Murphy T,Steves CJ,Dobson RJB,Proitsi P,Thuret S
Thu Apr 02 00:00:00 EDT 2020
Metabolic alterations in Parkinson's disease astrocytes.
Scientific reports
Sonninen TM,Hämäläinen RH,Koskuvi M,Oksanen M,Shakirzyanova A,Wojciechowski S,Puttonen K,Naumenko N,Goldsteins G,Laham-Karam N,Lehtonen M,Tavi P,Koistinaho J,Lehtonen Š
Wed Sep 02 00:00:00 EDT 2020
CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual.
Communications biology
Yun Y,Hong SA,Kim KK,Baek D,Lee D,Londhe AM,Lee M,Yu J,McEachin ZT,Bassell GJ,Bowser R,Hales CM,Cho SR,Kim J,Pae AN,Cheong E,Kim S,Boulis NM,Bae S,Ha Y
Mon Jan 20 00:00:00 EST 2020
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.
Nature communications
Matsumura K,Seiriki K,Okada S,Nagase M,Ayabe S,Yamada I,Furuse T,Shibuya H,Yasuda Y,Yamamori H,Fujimoto M,Nagayasu K,Yamamoto K,Kitagawa K,Miura H,Gotoda-Nishimura N,Igarashi H,Hayashida M,Baba M,Kondo M,Hasebe S,Ueshima K,Kasai A,Ago Y,Hayata-Takano A,Shintani N,Iguchi T,Sato M,Yamaguchi S,Tamura M,Wakana S,Yoshiki A,Watabe AM,Okano H,Takuma K,Hashimoto R,Hashimoto H,Nakazawa T
Wed Feb 26 00:00:00 EST 2020
DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation.
Proceedings of the National Academy of Sciences of the United States of America
Cao K,Ugarenko M,Ozark PA,Wang J,Marshall SA,Rendleman EJ,Liang K,Wang L,Zou L,Smith ER,Yue F,Shilatifard A
Tue Nov 03 00:00:00 EST 2020
Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis.
Scientific reports
Hasaart KAL,Manders F,van der Hoorn ML,Verheul M,Poplonski T,Kuijk E,de Sousa Lopes SMC,van Boxtel R
Fri Jul 31 00:00:00 EDT 2020
Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma.
Cell death & disease
Dai W,Jin X,Han L,Huang H,Ji Z,Xu X,Tang M,Jiang B,Chen W
Fri Sep 11 00:00:00 EDT 2020
WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer.
Cell death & disease
Ertay A,Liu H,Liu D,Peng P,Hill C,Xiong H,Hancock D,Yuan X,Przewloka MR,Coldwell M,Howell M,Skipp P,Ewing RM,Downward J,Wang Y
Sat Nov 21 00:00:00 EST 2020
TGF-β induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer.
Scientific reports
Kim BN,Ahn DH,Kang N,Yeo CD,Kim YK,Lee KY,Kim TJ,Lee SH,Park MS,Yim HW,Park JY,Park CK,Kim SJ
Tue Jun 30 00:00:00 EDT 2020
Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feng L,Chao J,Tian E,Li L,Ye P,Zhang M,Chen X,Cui Q,Sun G,Zhou T,Felix G,Qin Y,Li W,Meza ED,Klein J,Ghoda L,Hu W,Luo Y,Dang W,Hsu D,Gold J,Goldman SA,Matalon R,Shi Y
Tue Dec 01 00:00:00 EST 2020
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities.
Nature communications
Narayan RS,Molenaar P,Teng J,Cornelissen FMG,Roelofs I,Menezes R,Dik R,Lagerweij T,Broersma Y,Petersen N,Marin Soto JA,Brands E,van Kuiken P,Lecca MC,Lenos KJ,In 't Veld SGJG,van Wieringen W,Lang FF,Sulman E,Verhaak R,Baumert BG,Stalpers LJA,Vermeulen L,Watts C,Bailey D,Slotman BJ,Versteeg R,Noske D,Sminia P,Tannous BA,Wurdinger T,Koster J,Westerman BA
Wed Jun 10 00:00:00 EDT 2020
Novel Analytical Platform For Robust Identification of Cell Migration Inhibitors.
Scientific reports
Somchai P,Phongkitkarun K,Kueanjinda P,Jamnongsong S,Vaeteewoottacharn K,Luvira V,Okada S,Jirawatnotai S,Sampattavanich S
AF-100-15 was used in In vitro experiments to test cell migration inhibitors.
Wed Jan 22 00:00:00 EST 2020
p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids.
Cell death & disease
Marin Navarro A,Pronk RJ,van der Geest AT,Oliynyk G,Nordgren A,Arsenian-Henriksson M,Falk A,Wilhelm M
Thu Jan 23 00:00:00 EST 2020
Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib.
Cell death & disease
Florent R,Weiswald LB,Lambert B,Brotin E,Abeilard E,Louis MH,Babin G,Poulain L,N'Diaye M
Mon May 18 00:00:00 EDT 2020
Metabolism and pharmacokinetics of a novel polyphenol fatty acid ester phloridzin docosahexaenoate in Balb/c female mice.
Scientific reports
Fernando W,Goralski KB,Hoskin DW,Rupasinghe HPV
Mon Dec 07 00:00:00 EST 2020
Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids.
Nature communications
McEvoy E,Han YL,Guo M,Shenoy VB
Tue Dec 01 00:00:00 EST 2020
Predicting Radiation Resistance in Breast Cancer with Expression Status of Phosphorylated S6K1.
Scientific reports
Choi J,Yoon YN,Kim N,Park CS,Seol H,Park IC,Kim HA,Noh WC,Kim JS,Seong MK
Mon Jan 20 00:00:00 EST 2020
In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals.
Cell discovery
Lin JY,Cheng J,Du YQ,Pan W,Zhang Z,Wang J,An J,Yang F,Xu YF,Lin H,An WT,Wang J,Yang Z,Chai RJ,Sha XY,Hu HL,Sun JP,Yu X
Tue Oct 03 00:00:00 EDT 2023
In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals.
Cell discovery
Lin JY,Cheng J,Du YQ,Pan W,Zhang Z,Wang J,An J,Yang F,Xu YF,Lin H,An WT,Wang J,Yang Z,Chai RJ,Sha XY,Hu HL,Sun JP,Yu X
Tue Oct 03 00:00:00 EDT 2023
Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
EBioMedicine
Lu HH,Lin SY,Weng RR,Juan YH,Chen YW,Hou HH,Hung ZC,Oswita GA,Huang YJ,Guu SY,Khoo KH,Shih JY,Yu CJ,Tsai HC
AF-100-15 was used in Cell Culture to study the molecular mechanisms of the key fucosyltransferase with prognostic significance in lung cancer patients and the enzyme's intracellular targets to demonstrate that FUT4 can be a prognostic predictor and therapeutic target in lung cancer metastasis.
Wed Jul 01 00:00:00 EDT 2020
Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model.
eLife
Lee H,Lee HY,Lee BE,Gerovska D,Park SY,Zaehres H,Araúzo-Bravo MJ,Kim JI,Ha Y,Schöler HR,Kim JB
AF-100-15 was used in Cell Culture to investigate the use of induced motor neurons to treat spinal cord injury.
Tue Jun 23 00:00:00 EDT 2020
Establishment of Pancreatic Organoids from Normal Tissue and Tumors.
STAR protocols
Driehuis E,Gracanin A,Vries RGJ,Clevers H,Boj SF
AF-100-15 was used in Tissue/organ culture to detail the generation of pancreatic tumor organoid models that can be cryopreserved and serve as living biobank for drug screening.
Fri Dec 18 00:00:00 EST 2020
Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.
Cell
Lundby A,Franciosa G,Emdal KB,Refsgaard JC,Gnosa SP,Bekker-Jensen DB,Secher A,Maurya SR,Paul I,Mendez BL,Kelstrup CD,Francavilla C,Kveiborg M,Montoya G,Jensen LJ,Olsen JV
Thu Oct 03 00:00:00 EDT 2019
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.
Cell
Neftel C,Laffy J,Filbin MG,Hara T,Shore ME,Rahme GJ,Richman AR,Silverbush D,Shaw ML,Hebert CM,Dewitt J,Gritsch S,Perez EM,Gonzalez Castro LN,Lan X,Druck N,Rodman C,Dionne D,Kaplan A,Bertalan MS,Small J,Pelton K,Becker S,Bonal D,Nguyen QD,Servis RL,Fung JM,Mylvaganam R,Mayr L,Gojo J,Haberler C,Geyeregger R,Czech T,Slavc I,Nahed BV,Curry WT,Carter BS,Wakimoto H,Brastianos PK,Batchelor TT,Stemmer-Rachamimov A,Martinez-Lage M,Frosch MP,Stamenkovic I,Riggi N,Rheinbay E,Monje M,Rozenblatt-Rosen O,Cahill DP,Patel AP,Hunter T,Verma IM,Ligon KL,Louis DN,Regev A,Bernstein BE,Tirosh I,Suvà ML
Thu Aug 08 00:00:00 EDT 2019
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.
Cell
Neftel C,Laffy J,Filbin MG,Hara T,Shore ME,Rahme GJ,Richman AR,Silverbush D,Shaw ML,Hebert CM,Dewitt J,Gritsch S,Perez EM,Gonzalez Castro LN,Lan X,Druck N,Rodman C,Dionne D,Kaplan A,Bertalan MS,Small J,Pelton K,Becker S,Bonal D,Nguyen QD,Servis RL,Fung JM,Mylvaganam R,Mayr L,Gojo J,Haberler C,Geyeregger R,Czech T,Slavc I,Nahed BV,Curry WT,Carter BS,Wakimoto H,Brastianos PK,Batchelor TT,Stemmer-Rachamimov A,Martinez-Lage M,Frosch MP,Stamenkovic I,Riggi N,Rheinbay E,Monje M,Rozenblatt-Rosen O,Cahill DP,Patel AP,Hunter T,Verma IM,Ligon KL,Louis DN,Regev A,Bernstein BE,Tirosh I,Suvà ML
Thu Aug 08 00:00:00 EDT 2019
Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
Cell
Wang H,Xiang D,Liu B,He A,Randle HJ,Zhang KX,Dongre A,Sachs N,Clark AP,Tao L,Chen Q,Botchkarev VV,Xie Y,Dai N,Clevers H,Li Z,Livingston DM
Thu Jun 27 00:00:00 EDT 2019
Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.
Cell
Gehart H,van Es JH,Hamer K,Beumer J,Kretzschmar K,Dekkers JF,Rios A,Clevers H
Thu Feb 21 00:00:00 EST 2019
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.
Cell
Moon SH,Huang CH,Houlihan SL,Regunath K,Freed-Pastor WA,Morris JP,Tschaharganeh DF,Kastenhuber ER,Barsotti AM,Culp-Hill R,Xue W,Ho YJ,Baslan T,Li X,Mayle A,de Stanchina E,Zender L,Tong DR,D'Alessandro A,Lowe SW,Prives C
Thu Jan 24 00:00:00 EST 2019
Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens.
Cell research
Fu GB,Huang WJ,Zeng M,Zhou X,Wu HP,Liu CC,Wu H,Weng J,Zhang HD,Cai YC,Ashton C,Ding M,Tang D,Zhang BH,Gao Y,Yu WF,Zhai B,He ZY,Wang HY,Yan HX
Tue Jan 01 00:00:00 EST 2019
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
Cancer cell
Jackstadt R,van Hooff SR,Leach JD,Cortes-Lavaud X,Lohuis JO,Ridgway RA,Wouters VM,Roper J,Kendall TJ,Roxburgh CS,Horgan PG,Nixon C,Nourse C,Gunzer M,Clark W,Hedley A,Yilmaz OH,Rashid M,Bailey P,Biankin AV,Campbell AD,Adams DJ,Barry ST,Steele CW,Medema JP,Sansom OJ
Mon Sep 16 00:00:00 EDT 2019
A Pharmacogenomic Landscape in Human Liver Cancers.
Cancer cell
Qiu Z,Li H,Zhang Z,Zhu Z,He S,Wang X,Wang P,Qin J,Zhuang L,Wang W,Xie F,Gu Y,Zou K,Li C,Li C,Wang C,Cen J,Chen X,Shu Y,Zhang Z,Sun L,Min L,Fu Y,Huang X,Lv H,Zhou H,Ji Y,Zhang Z,Meng Z,Shi X,Zhang H,Li Y,Hui L
Mon Aug 12 00:00:00 EDT 2019
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.
Cancer cell
Gomes AP,Ilter D,Low V,Rosenzweig A,Shen ZJ,Schild T,Rivas MA,Er EE,McNally DR,Mutvei AP,Han J,Ou YH,Cavaliere P,Mullarky E,Nagiec M,Shin S,Yoon SO,Dephoure N,Massagué J,Melnick AM,Cantley LC,Tyler JK,Blenis J
Mon Oct 14 00:00:00 EDT 2019
Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.
Cancer cell
Yin N,Liu Y,Khoor A,Wang X,Thompson EA,Leitges M,Justilien V,Weems C,Murray NR,Fields AP
Mon Aug 12 00:00:00 EDT 2019
Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.
Cancer cell
Zhang L,He X,Liu X,Zhang F,Huang LF,Potter AS,Xu L,Zhou W,Zheng T,Luo Z,Berry KP,Pribnow A,Smith SM,Fuller C,Jones BV,Fouladi M,Drissi R,Yang ZJ,Gustafson WC,Remke M,Pomeroy SL,Girard EJ,Olson JM,Morrissy AS,Vladoiu MC,Zhang J,Tian W,Xin M,Taylor MD,Potter SS,Roussel MF,Weiss WA,Lu QR
Mon Sep 16 00:00:00 EDT 2019
Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.
Cancer cell
Zhang L,He X,Liu X,Zhang F,Huang LF,Potter AS,Xu L,Zhou W,Zheng T,Luo Z,Berry KP,Pribnow A,Smith SM,Fuller C,Jones BV,Fouladi M,Drissi R,Yang ZJ,Gustafson WC,Remke M,Pomeroy SL,Girard EJ,Olson JM,Morrissy AS,Vladoiu MC,Zhang J,Tian W,Xin M,Taylor MD,Potter SS,Roussel MF,Weiss WA,Lu QR
Mon Sep 16 00:00:00 EDT 2019
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.
Cancer cell
Carugo A,Minelli R,Sapio L,Soeung M,Carbone F,Robinson FS,Tepper J,Chen Z,Lovisa S,Svelto M,Amin S,Srinivasan S,Del Poggetto E,Loponte S,Puca F,Dey P,Malouf GG,Su X,Li L,Lopez-Terrada D,Rakheja D,Lazar AJ,Netto GJ,Rao P,Sgambato A,Maitra A,Tripathi DN,Walker CL,Karam JA,Heffernan TP,Viale A,Roberts CWM,Msaouel P,Tannir NM,Draetta GF,Genovese G
Mon Feb 11 00:00:00 EST 2019
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
The Journal of clinical investigation
Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C
Fri Mar 01 00:00:00 EST 2019
The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13.
The Journal of clinical investigation
Hu Y,Zhang M,Tian N,Li D,Wu F,Hu P,Wang Z,Wang L,Hao W,Kang J,Yin B,Zheng Z,Jiang T,Yuan J,Qiang B,Han W,Peng X
Tue May 21 00:00:00 EDT 2019
N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer.
The Journal of clinical investigation
Berger A,Brady NJ,Bareja R,Robinson B,Conteduca V,Augello MA,Puca L,Ahmed A,Dardenne E,Lu X,Hwang I,Bagadion AM,Sboner A,Elemento O,Paik J,Yu J,Barbieri CE,Dephoure N,Beltran H,Rickman DS
Mon Jul 01 00:00:00 EDT 2019
Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN.
Neuron
Tang C,Wang M,Wang P,Wang L,Wu Q,Guo W
Wed Jan 02 00:00:00 EST 2019
Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion.
Neuron
Matsuda T,Irie T,Katsurabayashi S,Hayashi Y,Nagai T,Hamazaki N,Adefuin AMD,Miura F,Ito T,Kimura H,Shirahige K,Takeda T,Iwasaki K,Imamura T,Nakashima K
Wed Feb 06 00:00:00 EST 2019
Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.
The Journal of experimental medicine
Lee PH,Yamamoto TN,Gurusamy D,Sukumar M,Yu Z,Hu-Li J,Kawabe T,Gangaplara A,Kishton RJ,Henning AN,Vodnala SK,Germain RN,Paul WE,Restifo NP
Mon Nov 04 00:00:00 EST 2019
Human colon organoids reveal distinct physiologic and oncogenic Wnt responses.
The Journal of experimental medicine
Michels BE,Mosa MH,Grebbin BM,Yepes D,Darvishi T,Hausmann J,Urlaub H,Zeuzem S,Kvasnicka HM,Oellerich T,Farin HF
Mon Mar 04 00:00:00 EST 2019
Engineering, delivery, and biological validation of artificial microRNA clusters for gene therapy applications.
Nature protocols
Bhaskaran V,Yao Y,Bei F,Peruzzi P
AF-100-15 was used in Cell Culture to show that this protocol is quick and flexible and does not require special laboratory equipment or techniques, or multiple cloning steps.
Sun Dec 01 00:00:00 EST 2019
Reversing tumor stemness via orally targeted nanoparticles achieves efficient colon cancer treatment.
Biomaterials
Xu J,Zhang Y,Xu J,Wang M,Liu G,Wang J,Zhao X,Qi Y,Shi J,Cheng K,Li Y,Qi S,Nie G
AF-100-15 was used in In vitro experiments to show that n oral drug delivery system for sustained release of BMI-1 inhibitor (PTC209) reverses the stemness of CRC where nanoparticles modified with hyaluronic acid (HA) showed high-affinity to CD44/CD168 overexpressed-CRC cells, and efficiently targeted to tumor site in a metastatic orthotropic colon cancer mouse model by oral administration which results in tumor growth inhibition accompanied by decreased expression of stemness markers
Sun Sep 01 00:00:00 EDT 2019
The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma.
EMBO molecular medicine
Lin S,Huang C,Sun J,Bollt O,Wang X,Martine E,Kang J,Taylor MD,Fang B,Singh PK,Koomen J,Hao J,Yang S
Sun Dec 01 00:00:00 EST 2019
Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression.
EMBO molecular medicine
Li H,Yang F,Hu A,Wang X,Fang E,Chen Y,Li D,Song H,Wang J,Guo Y,Liu Y,Li H,Huang K,Zheng L,Tong Q
Sun Dec 01 00:00:00 EST 2019
Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.
EMBO molecular medicine
Le Joncour V,Filppu P,Hyvönen M,Holopainen M,Turunen SP,Sihto H,Burghardt I,Joensuu H,Tynninen O,Jääskeläinen J,Weller M,Lehti K,Käkelä R,Laakkonen P
Sat Jun 01 00:00:00 EDT 2019
Long-term expanding human airway organoids for disease modeling.
The EMBO journal
Sachs N,Papaspyropoulos A,Zomer-van Ommen DD,Heo I,Böttinger L,Klay D,Weeber F,Huelsz-Prince G,Iakobachvili N,Amatngalim GD,de Ligt J,van Hoeck A,Proost N,Viveen MC,Lyubimova A,Teeven L,Derakhshan S,Korving J,Begthel H,Dekkers JF,Kumawat K,Ramos E,van Oosterhout MF,Offerhaus GJ,Wiener DJ,Olimpio EP,Dijkstra KK,Smit EF,van der Linden M,Jaksani S,van de Ven M,Jonkers J,Rios AC,Voest EE,van Moorsel CH,van der Ent CK,Cuppen E,van Oudenaarden A,Coenjaerts FE,Meyaard L,Bont LJ,Peters PJ,Tans SJ,van Zon JS,Boj SF,Vries RG,Beekman JM,Clevers H
Fri Feb 15 00:00:00 EST 2019
Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG.
Bone research
Chen CY,Rao SS,Tan YJ,Luo MJ,Hu XK,Yin H,Huang J,Hu Y,Luo ZW,Liu ZZ,Wang ZX,Cao J,Liu YW,Li HM,Chen Y,Du W,Liu JH,Zhang Y,Chen TH,Liu HM,Wu B,Yue T,Wang YY,Xia K,Lei PF,Tang SY,Xie H
Wed Sep 30 00:00:00 EDT 2020
Fast fit-free analysis of fluorescence lifetime imaging via deep learning.
Proceedings of the National Academy of Sciences of the United States of America
Smith JT,Yao R,Sinsuebphon N,Rudkouskaya A,Un N,Mazurkiewicz J,Barroso M,Yan P,Intes X
Tue Nov 26 00:00:00 EST 2019
A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.
Proceedings of the National Academy of Sciences of the United States of America
Florian S,Iwamoto Y,Coughlin M,Weissleder R,Mitchison TJ
Tue Jun 04 00:00:00 EDT 2019
Peripheral (not central) corneal epithelia contribute to the closure of an annular debridement injury.
Proceedings of the National Academy of Sciences of the United States of America
Park M,Richardson A,Pandzic E,Lobo EP,Lyons JG,Di Girolamo N
Thu Dec 26 00:00:00 EST 2019
ERK-dependent phosphorylation of the linker and substrate-binding domain of HSP70 increases folding activity and cell proliferation.
Experimental & molecular medicine
Lim S,Kim DG,Kim S
Thu Sep 26 00:00:00 EDT 2019
ERK-dependent phosphorylation of the linker and substrate-binding domain of HSP70 increases folding activity and cell proliferation.
Experimental & molecular medicine
Lim S,Kim DG,Kim S
Thu Sep 26 00:00:00 EDT 2019
The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation.
Cell death and differentiation
Battistelli C,Sabarese G,Santangelo L,Montaldo C,Gonzalez FJ,Tripodi M,Cicchini C
Wed May 01 00:00:00 EDT 2019
Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival.
British journal of cancer
Rahman MA,Gras Navarro A,Brekke J,Engelsen A,Bindesbøll C,Sarowar S,Bahador M,Bifulco E,Goplen D,Waha A,Lie SA,Gjertsen BT,Selheim F,Enger PØ,Simonsen A,Chekenya M
Tue Oct 01 00:00:00 EDT 2019
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.
Oncogene
He W,Liang B,Wang C,Li S,Zhao Y,Huang Q,Liu Z,Yao Z,Wu Q,Liao W,Zhang S,Liu Y,Xiang Y,Liu J,Shi M
Sat Jun 01 00:00:00 EDT 2019
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Oncogene
Wagner S,Vlachogiannis G,De Haven Brandon A,Valenti M,Box G,Jenkins L,Mancusi C,Self A,Manodoro F,Assiotis I,Robinson P,Chauhan R,Rust AG,Matthews N,Eason K,Khan K,Starling N,Cunningham D,Sadanandam A,Isacke CM,Kirkin V,Valeri N,Whittaker SR
Fri Mar 01 00:00:00 EST 2019
Unbalanced YAP-SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma.
Oncogene
Wang L,Zhang Z,Yu X,Huang X,Liu Z,Chai Y,Yang L,Wang Q,Li M,Zhao J,Hou J,Li F
Fri Mar 01 00:00:00 EST 2019
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Oncogene
Sun B,Zhao X,Ming J,Liu X,Liu D,Jiang C
Thu Aug 01 00:00:00 EDT 2019
Six2 promotes non-small cell lung cancer cell stemness via transcriptionally and epigenetically regulating E-cadherin.
Cell proliferation
Hou H,Yu X,Cong P,Zhou Y,Xu Y,Jiang Y
Mon Jul 01 00:00:00 EDT 2019
Ganglioside GM1 promotes contact inhibition of growth by regulating the localization of epidermal growth factor receptor from glycosphingolipid-enriched microdomain to caveolae.
Cell proliferation
Zhuo D,Guan F
Mon Jul 01 00:00:00 EDT 2019
HDAC7-mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells.
Molecular oncology
Cutano V,Di Giorgio E,Minisini M,Picco R,Dalla E,Brancolini C
Thu Aug 01 00:00:00 EDT 2019
HDAC7-mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells.
Molecular oncology
Cutano V,Di Giorgio E,Minisini M,Picco R,Dalla E,Brancolini C
Thu Aug 01 00:00:00 EDT 2019
Hypoxia-inducible factor-2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin.
Molecular oncology
He M,Wu H,Jiang Q,Liu Y,Han L,Yan Y,Wei B,Liu F,Deng X,Chen H,Zhao L,Wang M,Wu X,Yao W,Zhao H,Chen J,Wei M
Fri Feb 01 00:00:00 EST 2019
FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics.
Oxidative medicine and cellular longevity
Li X,Hong Y,He H,Jiang G,You W,Liang X,Fu Q,Han S,Lian Q,Zhang Y
AF-100-15 was used in Cell Culture to study the mechanisms of fibroblast growth factor 21 in the regulation of mesenchymal stem cell senescence.
Thu Jan 16 00:00:00 EST 2020
LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation.
Oncogenesis
Morén A,Bellomo C,Tsubakihara Y,Kardassis D,Mikulits W,Heldin CH,Moustakas A
Thu May 16 00:00:00 EDT 2019
Novel tumor suppressor role of miRNA-876 in cholangiocarcinoma.
Oncogenesis
Ursu S,Majid S,Garger C,de Semir D,Bezrookove V,Desprez PY,McAllister S,Soroceanu L,Nosrati M,Yimam K,Hassoun A,Osorio R,Kashani-Sabet M,Dar AA
Tue Aug 13 00:00:00 EDT 2019
Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis.
Cancer science
Raja E,Morikawa M,Nishida J,Tanabe R,Takahashi K,Seeherman HJ,Saito N,Todo T,Miyazono K
Fri Nov 01 00:00:00 EDT 2019
Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition.
Journal of cellular physiology
de Jong OG,van der Waals LM,Kools FRW,Verhaar MC,van Balkom BWM
Mon Jul 01 00:00:00 EDT 2019
Poly(ADP-Ribose) Polymerase Inhibition Sensitizes Colorectal Cancer-Initiating Cells to Chemotherapy.
Stem cells (Dayton, Ohio)
Jarrar A,Lotti F,DeVecchio J,Ferrandon S,Gantt G,Mace A,Karagkounis G,Orloff M,Venere M,Hitomi M,Lathia J,Rich JN,Kalady MF
Tue Jan 01 00:00:00 EST 2019
Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin.
Stem cells (Dayton, Ohio)
Shan J,Shen J,Wu M,Zhou H,Feng J,Yao C,Yang Z,Ma Q,Luo Y,Wang Y,Qian C
Fri Nov 01 00:00:00 EDT 2019
Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer.
Journal of immunology (Baltimore, Md. : 1950)
Biswas S,Mandal G,Roy Chowdhury S,Purohit S,Payne KK,Anadon C,Gupta A,Swanson P,Yu X,Conejo-Garcia JR,Bhattacharyya A
Sun Dec 15 00:00:00 EST 2019
Long non-coding RNA SNHG20 promotes the tumorigenesis of oral squamous cell carcinoma via targeting miR-197/LIN28 axis.
Journal of cellular and molecular medicine
Wu J,Zhao W,Wang Z,Xiang X,Zhang S,Liu L
Tue Jan 01 00:00:00 EST 2019
PFN1 and integrin-β1/mTOR axis involvement in cornea differentiation of fibroblast limbal stem cells.
Journal of cellular and molecular medicine
Tomasello L,Coppola A,Pitrone M,Failla V,Cillino S,Pizzolanti G,Giordano C
Fri Nov 01 00:00:00 EDT 2019
The role of insulin in transdifferentiated hepatocyte proliferation and function in serum-free medium.
Journal of cellular and molecular medicine
Gu C,Li P,Liu W,Zhou Y,Tan WS
Sat Jun 01 00:00:00 EDT 2019
DLG5 suppresses breast cancer stem cell-like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression.
Journal of cellular and molecular medicine
Liu J,Li J,Li P,Jiang Y,Chen H,Wang R,Cao F,Liu P
Tue Jan 01 00:00:00 EST 2019
TP53INP2 mediates autophagic degradation of ubiquitinated proteins through its ubiquitin-interacting motif.
FEBS letters
Xu Y,Wan W
AF-100-15 was used in Cell Culture to investigate TP53INP2 in autophagy and thus treatment of cancer with chloroquine.
Thu Aug 01 00:00:00 EDT 2019
Overexpression of CMTM7 inhibits cell growth and migration in liver cancer.
The Kaohsiung journal of medical sciences
Huang ZM,Li PL,Yang P,Hou XD,Yang YL,Xu X,Xu F
Sat Jun 01 00:00:00 EDT 2019
Organoid-derived C-Kit+/SSEA4- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents.
Nature communications
Zou T,Gao L,Zeng Y,Li Q,Li Y,Chen S,Hu X,Chen X,Fu C,Xu H,Yin ZQ
Thu Mar 14 00:00:00 EDT 2019
iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds.
Stem cell reports
Faley SL,Neal EH,Wang JX,Bosworth AM,Weber CM,Balotin KM,Lippmann ES,Bellan LM
Tue Mar 05 00:00:00 EST 2019
Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-α-stimulated gene-6 in inflammatory bowel disease models.
Cell death & disease
Yang H,Feng R,Fu Q,Xu S,Hao X,Qiu Y,Feng T,Zeng Z,Chen M,Zhang S
Thu Sep 26 00:00:00 EDT 2019
Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2.
Cell death & disease
Chen Y,Chen L,Hong D,Chen Z,Zhang J,Fu L,Pan D,Zhang Y,Xu Y,Gan S,Xiao C,Tao L,Shen X
Thu Apr 18 00:00:00 EDT 2019
SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells.
Cell death & disease
Li J,Li N,Chen Y,Hui S,Fan J,Ye B,Fan Z,Zhang J,Zhao RC,Zhuang Q
Wed Oct 23 00:00:00 EDT 2019
Simple oral mucosal epithelial transplantation in a rabbit model.
Scientific reports
Inamochi A,Tomioka A,Kitamoto K,Miyai T,Usui T,Aihara M,Yamagami S
Mon Dec 02 00:00:00 EST 2019
Clozapine-dependent inhibition of EGF/neuregulin receptor (ErbB) kinases.
Translational psychiatry
Kobayashi Y,Iwakura Y,Sotoyama H,Kitayama E,Takei N,Someya T,Nawa H
Thu Aug 01 00:00:00 EDT 2019
Clozapine-dependent inhibition of EGF/neuregulin receptor (ErbB) kinases.
Translational psychiatry
Kobayashi Y,Iwakura Y,Sotoyama H,Kitayama E,Takei N,Someya T,Nawa H
Thu Aug 01 00:00:00 EDT 2019
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide.
Nature communications
Wu LP,Ahmadvand D,Su J,Hall A,Tan X,Farhangrazi ZS,Moghimi SM
Fri Oct 11 00:00:00 EDT 2019
YAP-independent mechanotransduction drives breast cancer progression.
Nature communications
Lee JY,Chang JK,Dominguez AA,Lee HP,Nam S,Chang J,Varma S,Qi LS,West RB,Chaudhuri O
Tue Apr 23 00:00:00 EDT 2019
Mutations in the mitochondrial tryptophanyl-tRNA synthetase cause growth retardation and progressive leukoencephalopathy.
Molecular genetics & genomic medicine
Maffezzini C,Laine I,Dallabona C,Clemente P,Calvo-Garrido J,Wibom R,Naess K,Barbaro M,Falk A,Donnini C,Freyer C,Wredenberg A,Wedell A
Sat Jun 01 00:00:00 EDT 2019
Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions.
Cell reports
Co JY,Margalef-Català M,Li X,Mah AT,Kuo CJ,Monack DM,Amieva MR
AF-100-15 was used in In vitro experiments to develop a technique to reverse enteroid polarity in Human enteroids-epithelial spheroids so the apical surface everts to face the media.
Tue Feb 26 00:00:00 EST 2019
Long noncoding RNA LINC02582 acts downstream of miR-200c to promote radioresistance through CHK1 in breast cancer cells.
Cell death & disease
Wang B,Zheng J,Li R,Tian Y,Lin J,Liang Y,Sun Q,Xu A,Zheng R,Liu M,Ji A,Bu J,Yuan Y
Thu Oct 10 00:00:00 EDT 2019
Adipose-derived stromal/stem cells improve epidermal homeostasis.
Scientific reports
Moriyama M,Sahara S,Zaiki K,Ueno A,Nakaoji K,Hamada K,Ozawa T,Tsuruta D,Hayakawa T,Moriyama H
Wed Dec 04 00:00:00 EST 2019
MoNa - A Cost-Efficient, Portable System for the Nanoinjection of Living Cells.
Scientific reports
Simonis M,Sandmeyer A,Greiner J,Kaltschmidt B,Huser T,Hennig S
Tue Apr 02 00:00:00 EDT 2019
Targeting of replicating CD133 and OCT4/SOX2 expressing glioma stem cells selects a cell population that reinitiates tumors upon release of therapeutic pressure.
Scientific reports
Guerra-Rebollo M,Garrido C,Sánchez-Cid L,Soler-Botija C,Meca-Cortés O,Rubio N,Blanco J
Tue Jul 02 00:00:00 EDT 2019
Alternative splicing-derived intersectin1-L and intersectin1-S exert opposite function in glioma progression.
Cell death & disease
Shao Y,Chong W,Liu X,Xu Y,Zhang H,Xu Q,Guo Z,Zhao Y,Zhang M,Ma Y,Gu F
Mon Jun 03 00:00:00 EDT 2019
Chronic CagA-positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell-like properties in gastric mucosal epithelial cells.
Journal of cellular biochemistry
Lin L,Wei H,Yi J,Xie B,Chen J,Zhou C,Wang L,Yang Y
AF-100-15 was used in Cell Culture to illustrate that chronic CagA-positive H. pylori infection stimulated by MNNG induces CSC-like and mesenchymal properties of gastric mucosal epithelial cells in a synergistic manner.
Tue Oct 01 00:00:00 EDT 2019
Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.
Scientific reports
Kang HM,Lim JH,Noh KH,Park D,Cho HS,Susztak K,Jung CR
Tue Nov 26 00:00:00 EST 2019
Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.
The Journal of biological chemistry
Singh A,Mia MM,Cibi DM,Arya AK,Bhadada SK,Singh MK
Fri May 24 00:00:00 EDT 2019
Optical control of protein phosphatase function.
Nature communications
Courtney TM,Deiters A
Thu Sep 26 00:00:00 EDT 2019
MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.
Nature communications
Annunziata I,van de Vlekkert D,Wolf E,Finkelstein D,Neale G,Machado E,Mosca R,Campos Y,Tillman H,Roussel MF,Andrew Weesner J,Ellen Fremuth L,Qiu X,Han MJ,Grosveld GC,d'Azzo A
Fri Aug 09 00:00:00 EDT 2019
An ultrasensitive fiveplex activity assay for cellular kinases.
Scientific reports
Smolko CM,Janes KA
Thu Dec 19 00:00:00 EST 2019
Protease Nexin I is a feedback regulator of EGF/PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness.
Cell death & disease
Tang T,Zhu Q,Li X,Zhu G,Deng S,Wang Y,Ni L,Chen X,Zhang Y,Xia T,Zen K,Pan Y,Jin L
Mon Sep 09 00:00:00 EDT 2019
Microfluidic reactors for advancing the MS analysis of fast biological responses.
Microsystems & nanoengineering
Lazar IM,Deng J,Stremler MA,Ahuja S
Tue Sep 14 00:00:00 EDT 2021
Deciphering the complex role of thrombospondin-1 in glioblastoma development.
Nature communications
Daubon T,Léon C,Clarke K,Andrique L,Salabert L,Darbo E,Pineau R,Guérit S,Maitre M,Dedieu S,Jeanne A,Bailly S,Feige JJ,Miletic H,Rossi M,Bello L,Falciani F,Bjerkvig R,Bikfalvi A
Fri Mar 08 00:00:00 EST 2019
ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma.
Cell death & disease
Liang B,Chen R,Song S,Wang H,Sun G,Yang H,Jing W,Zhou X,Fu Z,Huang G,Zhao J
Mon Nov 04 00:00:00 EST 2019
Aquaporin 3 maintains the stemness of CD133+ hepatocellular carcinoma cells by activating STAT3.
Cell death & disease
Wang Y,Wu G,Fu X,Xu S,Wang T,Zhang Q,Yang Y
Thu Jun 13 00:00:00 EDT 2019
Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Xiao Y,Kim D,Dura B,Zhang K,Yan R,Li H,Han E,Ip J,Zou P,Liu J,Chen AT,Vortmeyer AO,Zhou J,Fan R
Wed Apr 17 00:00:00 EDT 2019
A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer.
Cell death & disease
Mazzoldi EL,Pavan S,Pilotto G,Leone K,Pagotto A,Frezzini S,Nicoletto MO,Amadori A,Pastò A
Tue May 28 00:00:00 EDT 2019
Postinjury Inhibition of miR-181a Promotes Restoration of Hippocampal CA1 Neurons after Transient Forebrain Ischemia in Rats.
eNeuro
Griffiths BB,Ouyang YB,Xu L,Sun X,Giffard RG,Stary CM
AF-100-15 was used in In vitro experiments to evaluate the use of anti-miR-181a for postinjury treatment of CA1 neuron recovery.
Thu Mar 05 00:00:00 EST 2020
Isolation and Culture of Glioblastoma Brain Tumor Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Chesnelong C,Restall I,Weiss S
AF-100-15 was used in Cell Culture to describe a method to isolate and culture BTSCs from fresh GBM patient samples.
Mon May 27 00:00:00 EDT 2019
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription.
Nature communications
Yu JM,Sun W,Wang ZH,Liang X,Hua F,Li K,Lv XX,Zhang XW,Liu YY,Yu JJ,Liu SS,Shang S,Wang F,Yang ZN,Zhao CX,Hou XY,Li PP,Huang B,Cui B,Hu ZW
Mon Dec 16 00:00:00 EST 2019
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death.
Scientific reports
Ajmone-Cat MA,Onori A,Toselli C,Stronati E,Morlando M,Bozzoni I,Monni E,Kokaia Z,Lupo G,Minghetti L,Biagioni S,Cacci E
Thu Mar 14 00:00:00 EDT 2019
Cytokine Selection of MSC Clones with Different Functionality.
Stem cell reports
Selich A,Ha TC,Morgan M,Falk CS,von Kaisenberg C,Schambach A,Rothe M
Tue Aug 13 00:00:00 EDT 2019
5-Fluorouracil treatment induces characteristic T>G mutations in human cancer.
Nature communications
Christensen S,Van der Roest B,Besselink N,Janssen R,Boymans S,Martens JWM,Yaspo ML,Priestley P,Kuijk E,Cuppen E,Van Hoeck A
Tue Oct 08 00:00:00 EDT 2019
YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation.
Cell death & disease
Noce V,Battistelli C,Cozzolino AM,Consalvi V,Cicchini C,Strippoli R,Tripodi M,Marchetti A,Amicone L
Thu Oct 10 00:00:00 EDT 2019
Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride.
Scientific reports
Takizawa H,Hara Y,Mizobe Y,Ohno T,Suzuki S,Inoue K,Takeshita E,Shimizu-Motohashi Y,Ishiyama A,Hoshino M,Komaki H,Takeda S,Aoki Y
Thu Mar 07 00:00:00 EST 2019
Matrix Remodeling Enhances the Differentiation Capacity of Neural Progenitor Cells in 3D Hydrogels.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Madl CM,LeSavage BL,Dewi RE,Lampe KJ,Heilshorn SC
Wed Feb 20 00:00:00 EST 2019
Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease.
Scientific reports
Fujiyoshi J,Yamaza H,Sonoda S,Yuniartha R,Ihara K,Nonaka K,Taguchi T,Ohga S,Yamaza T
Thu Feb 07 00:00:00 EST 2019
Isolation of Neural Stem Cells from Whole Brain Tissues of Adult Mice.
Current protocols in stem cell biology
Deshpande K,Saatian B,Martirosian V,Lin M,Julian A,Neman J
AF-100-15 was used in Cell Culture to present a new protocol which facilitates adult neurospheres isolation, purification, maintenance, and differentiation.
Sat Jun 01 00:00:00 EDT 2019
Identification of cell context-dependent YAP-associated proteins reveals β1 and β4 integrin mediate YAP translocation independently of cell spreading.
Scientific reports
Lee JY,Dominguez AA,Nam S,Stowers RS,Qi LS,Chaudhuri O
Wed Nov 20 00:00:00 EST 2019
3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors.
Nature communications
Sood D,Tang-Schomer M,Pouli D,Mizzoni C,Raia N,Tai A,Arkun K,Wu J,Black LD,Scheffler B,Georgakoudi I,Steindler DA,Kaplan DL
Fri Oct 04 00:00:00 EDT 2019
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nature communications
Segal JM,Kent D,Wesche DJ,Ng SS,Serra M,Oulès B,Kar G,Emerton G,Blackford SJI,Darmanis S,Miquel R,Luong TV,Yamamoto R,Bonham A,Jassem W,Heaton N,Vigilante A,King A,Sancho R,Teichmann S,Quake SR,Nakauchi H,Rashid ST
Fri Jul 26 00:00:00 EDT 2019
A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhuang J,Zhang J,Wu M,Zhang Y
Fri Nov 01 00:00:00 EDT 2019
A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors.
Scientific reports
Ísberg ÓG,Kim J,Fridriksdottir AJ,Morsing M,Timmermans-Wielenga V,Rønnov-Jessen L,Petersen OW,Villadsen R
Wed Oct 16 00:00:00 EDT 2019
CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line.
Cancer medicine
Asai R,Tsuchiya H,Amisaki M,Makimoto K,Takenaga A,Sakabe T,Hoi S,Koyama S,Shiota G
Fri Feb 01 00:00:00 EST 2019
Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant.
Scientific reports
Ito K,Matsuura K,Mihara Y,Sakamoto Y,Hasegawa K,Kokudo N,Shimizu T
Thu Apr 11 00:00:00 EDT 2019
TAE226, a dual inhibitor of focal adhesion kinase and insulin-like growth factor-I receptor, is effective for Ewing sarcoma.
Cancer medicine
Moritake H,Saito Y,Sawa D,Sameshima N,Yamada A,Kinoshita M,Kamimura S,Konomoto T,Nunoi H
Sun Dec 01 00:00:00 EST 2019
Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling.
Stem cell reports
Akbari S,Sevinç GG,Ersoy N,Basak O,Kaplan K,Sevinç K,Ozel E,Sengun B,Enustun E,Ozcimen B,Bagriyanik A,Arslan N,Önder TT,Erdal E
Tue Oct 08 00:00:00 EDT 2019
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Nature communications
Zhao Y,Sun X,Hu D,Prosdocimo DA,Hoppel C,Jain MK,Ramachandran R,Qi X
Tue Mar 26 00:00:00 EDT 2019
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription.
Nature communications
Malik N,Yan H,Moshkovich N,Palangat M,Yang H,Sanchez V,Cai Z,Peat TJ,Jiang S,Liu C,Lee M,Mock BA,Yuspa SH,Larson D,Wakefield LM,Huang J
Mon May 06 00:00:00 EDT 2019
Electromagnetic fields alter the motility of metastatic breast cancer cells.
Communications biology
Garg AA,Jones TH,Moss SM,Mishra S,Kaul K,Ahirwar DK,Ferree J,Kumar P,Subramaniam D,Ganju RK,Subramaniam VV,Song JW
Tue Apr 14 00:00:00 EDT 2020
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy.
Nature communications
Pascual-García M,Bonfill-Teixidor E,Planas-Rigol E,Rubio-Perez C,Iurlaro R,Arias A,Cuartas I,Sala-Hojman A,Escudero L,Martínez-Ricarte F,Huber-Ruano I,Nuciforo P,Pedrosa L,Marques C,Braña I,Garralda E,Vieito M,Squatrito M,Pineda E,Graus F,Espejo C,Sahuquillo J,Tabernero J,Seoane J
Tue Jun 11 00:00:00 EDT 2019
The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis.
Scientific reports
Jain PB,Guerreiro PS,Canato S,Janody F
Fri Dec 27 00:00:00 EST 2019
PIC&RUN: An integrated assay for the detection and retrieval of single viable circulating tumor cells.
Scientific reports
Kamal M,Saremi S,Klotz R,Iriondo O,Amzaleg Y,Chairez Y,Tulpule V,Lang JE,Kang I,Yu M
Mon Nov 25 00:00:00 EST 2019
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Scientific reports
Calatayud C,Carola G,Fernández-Carasa I,Valtorta M,Jiménez-Delgado S,Díaz M,Soriano-Fradera J,Cappelletti G,García-Sancho J,Raya Á,Consiglio A
AF-100-15 was used in Cell Culture to investigate induced pluripotent stem cells use in Parkinson’s.
Thu May 02 00:00:00 EDT 2019
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Scientific reports
Calatayud C,Carola G,Fernández-Carasa I,Valtorta M,Jiménez-Delgado S,Díaz M,Soriano-Fradera J,Cappelletti G,García-Sancho J,Raya Á,Consiglio A
AF-100-15 was used in Cell Culture to investigate induced pluripotent stem cells use in Parkinson’s.
Thu May 02 00:00:00 EDT 2019
A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nature communications
Wang Z,Liu Z,Chen X,Li J,Yao W,Huang S,Gu A,Lei QY,Mao Y,Wen W
Thu Jul 18 00:00:00 EDT 2019
Genipin and EDC crosslinking of extracellular matrix hydrogel derived from human umbilical cord for neural tissue repair.
Scientific reports
Výborný K,Vallová J,Kočí Z,Kekulová K,Jiráková K,Jendelová P,Hodan J,Kubinová Š
Tue Jul 23 00:00:00 EDT 2019
Terminal fucose mediates progression of human cholangiocarcinoma through EGF/EGFR activation and the Akt/Erk signaling pathway.
Scientific reports
Indramanee S,Sawanyawisuth K,Silsirivanit A,Dana P,Phoomak C,Kariya R,Klinhom-On N,Sorin S,Wongkham C,Okada S,Wongkham S
Thu Nov 21 00:00:00 EST 2019
Terminal fucose mediates progression of human cholangiocarcinoma through EGF/EGFR activation and the Akt/Erk signaling pathway.
Scientific reports
Indramanee S,Sawanyawisuth K,Silsirivanit A,Dana P,Phoomak C,Kariya R,Klinhom-On N,Sorin S,Wongkham C,Okada S,Wongkham S
Thu Nov 21 00:00:00 EST 2019
MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer.
Nature communications
Zhan T,Ambrosi G,Wandmacher AM,Rauscher B,Betge J,Rindtorff N,Häussler RS,Hinsenkamp I,Bamberg L,Hessling B,Müller-Decker K,Erdmann G,Burgermeister E,Ebert MP,Boutros M
Thu May 16 00:00:00 EDT 2019
MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer.
Nature communications
Zhan T,Ambrosi G,Wandmacher AM,Rauscher B,Betge J,Rindtorff N,Häussler RS,Hinsenkamp I,Bamberg L,Hessling B,Müller-Decker K,Erdmann G,Burgermeister E,Ebert MP,Boutros M
Thu May 16 00:00:00 EDT 2019
Ddx4+ Oogonial Stem Cells in Postmenopausal Women's Ovaries: A Controversial, Undefined Role.
Cells
Silvestris E,Cafforio P,Felici C,Cormio G,D'Oronzo S
Fri Jun 28 00:00:00 EDT 2019
Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes.
Nature communications
Koedoot E,Fokkelman M,Rogkoti VM,Smid M,van de Sandt I,de Bont H,Pont C,Klip JE,Wink S,Timmermans MA,Wiemer EAC,Stoilov P,Foekens JA,Le Dévédec SE,Martens JWM,van de Water B
Fri Jul 05 00:00:00 EDT 2019
Live-cell Migration Assays to Study Motility of Neural andGlial (Oligodendrocyte) Progenitor Cells.
Bio-protocol
Chen CY,Chou FS,Wang PS
AF-100-15 was used in Cell Culture to study the cell type-specific mechanisms underlying migration of lineage- or disease-specific cells, such as neural and glial progenitor cells using a live-cell migration assay for use in the assessment of neural and glial progenitor cell migration.
Thu Jun 20 00:00:00 EDT 2019
Sustained NF-κB-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition.
Cell death discovery
da Hora CC,Pinkham K,Carvalho L,Zinter M,Tabet E,Nakano I,Tannous BA,Badr CE
Mon Sep 28 00:00:00 EDT 2020
Assessing the reliability of gene expression measurements in very-low-numbers of human monocyte-derived macrophages.
Scientific reports
Geiß C,Alanis-Lobato G,Andrade-Navarro M,Régnier-Vigouroux A
Fri Nov 29 00:00:00 EST 2019
Automated Segmentation of Fluorescence Microscopy Images for 3D Cell Detection in human-derived Cardiospheres.
Scientific reports
Salvi M,Morbiducci U,Amadeo F,Santoro R,Angelini F,Chimenti I,Massai D,Messina E,Giacomello A,Pesce M,Molinari F
Tue Apr 30 00:00:00 EDT 2019
The Orphan Nuclear Receptor TLX Represses Hes1 Expression, Thereby Affecting NOTCH Signaling and Lineage Progression in the Adult SEZ.
Stem cell reports
Luque-Molina I,Shi Y,Abdullah Y,Monaco S,Hölzl-Wenig G,Mandl C,Ciccolini F
Tue Jul 09 00:00:00 EDT 2019
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.
Nature communications
Tang F,Gao R,Jeevan-Raj B,Wyss CB,Kalathur RKR,Piscuoglio S,Ng CKY,Hindupur SK,Nuciforo S,Dazert E,Bock T,Song S,Buechel D,Morini MF,Hergovich A,Matthias P,Lim DS,Terracciano LM,Heim MH,Hall MN,Christofori G
Tue Dec 17 00:00:00 EST 2019
Identifying cystogenic paracrine signaling molecules in cyst fluid of patients with polycystic kidney disease.
American journal of physiology. Renal physiology
Kenter AT,van Rossum-Fikkert SE,Salih M,Verhagen PCMS,van Leenders GJLH,Demmers JAA,Jansen G,Gribnau J,Zietse R,Hoorn EJ
Tue Jan 01 00:00:00 EST 2019
LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1.
Scientific reports
Patel D,Ahmad F,Kambach DM,Sun Q,Halim AS,Kramp T,Camphausen KA,Stommel JM
Tue Oct 29 00:00:00 EDT 2019
Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells.
Scientific reports
Ballester M,Sentandreu E,Luongo G,Santamaria R,Bolonio M,Alcoriza-Balaguer MI,Palomino-Schätzlein M,Pineda-Lucena A,Castell J,Lahoz A,Bort R
Fri Nov 29 00:00:00 EST 2019
Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC.
Cancers
Modica TME,Dituri F,Mancarella S,Pisano C,Fabregat I,Giannelli G
AF-100-15 was used in Sample Preparation (Western Blotting) to suggest that besides EGFR, calcium could be a new therapeutic target in HCC.
Fri Oct 18 00:00:00 EDT 2019
Single-cell qPCR demonstrates that Repsox treatment changes cell fate from endoderm to neuroectoderm and disrupts epithelial-mesenchymal transition.
PloS one
Li Q,Huang Q
AF-100-15 was used in Cell Culture to show that the process of epithelial-to-mesenchymal transition, which is inherent to the process of definitive endoderm differentiation, was also disrupted upon Repsox treatment. Our findings may provide a new approach to produce neural progenitors.
Wed Mar 11 00:00:00 EDT 2020
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors.
Scientific reports
Petroni M,Sahùn Roncero M,Ramponi V,Fabretti F,Nicolis Di Robilant V,Moretti M,Alfano V,Corsi A,De Panfilis S,Giubettini M,Di Giulio S,Capalbo C,Belardinilli F,Coppa A,Sardina F,Colicchia V,Pedretti F,Infante P,Cardinali B,Tessitore A,Canettieri G,De Smaele E,Giannini G
Mon Dec 23 00:00:00 EST 2019
Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway.
Cell death & disease
Deshors P,Toulas C,Arnauduc F,Malric L,Siegfried A,Nicaise Y,Lemarié A,Larrieu D,Tosolini M,Cohen-Jonathan Moyal E,Courtade-Saidi M,Evrard SM
Mon Oct 28 00:00:00 EDT 2019
Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.
Cell death & disease
Grassi L,Alfonsi R,Francescangeli F,Signore M,De Angelis ML,Addario A,Costantini M,Flex E,Ciolfi A,Pizzi S,Bruselles A,Pallocca M,Simone G,Haoui M,Falchi M,Milella M,Sentinelli S,Di Matteo P,Stellacci E,Gallucci M,Muto G,Tartaglia M,De Maria R,Bonci D
Wed Feb 27 00:00:00 EST 2019
CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.
Scientific reports
McKenzie LD,LeClair JW,Miller KN,Strong AD,Chan HL,Oates EL,Ligon KL,Brennan CW,Chheda MG
Thu Mar 14 00:00:00 EDT 2019
A STAT3-based gene signature stratifies glioma patients for targeted therapy.
Nature communications
Tan MSY,Sandanaraj E,Chong YK,Lim SW,Koh LWH,Ng WH,Tan NS,Tan P,Ang BT,Tang C
Fri Aug 09 00:00:00 EDT 2019
miR-29a contributes to breast cancer cells epithelial-mesenchymal transition, migration, and invasion via down-regulating histone H4K20 trimethylation through directly targeting SUV420H2.
Cell death & disease
Wu Y,Shi W,Tang T,Wang Y,Yin X,Chen Y,Zhang Y,Xing Y,Shen Y,Xia T,Guo C,Pan Y,Jin L
Thu Feb 21 00:00:00 EST 2019
A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.
Nature communications
Boone PG,Rochelle LK,Ginzel JD,Lubkov V,Roberts WL,Nicholls PJ,Bock C,Flowers ML,von Furstenberg RJ,Stripp BR,Agarwal P,Borowsky AD,Cardiff RD,Barak LS,Caron MG,Lyerly HK,Snyder JC
Mon Dec 02 00:00:00 EST 2019
A dataset describing a suite of novel antibody reagents for the RAS signaling network.
Scientific data
Schoenherr RM,Huang D,Voytovich UJ,Ivey RG,Kennedy JJ,Saul RG,Colantonio S,Roberts RR,Knotts JG,Kaczmarczyk JA,Perry C,Hewitt SM,Bocik W,Whiteley GR,Hiltke T,Boja ES,Rodriguez H,Whiteaker JR,Paulovich AG
Thu Aug 29 00:00:00 EDT 2019
Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.
Cell chemical biology
Bum-Erdene K,Zhou D,Gonzalez-Gutierrez G,Ghozayel MK,Si Y,Xu D,Shannon HE,Bailey BJ,Corson TW,Pollok KE,Wells CD,Meroueh SO
AF-100-15 was used in Cell Culture to report small-molecule TEAD⋅Yap inhibitors that rapidly and selectively form a covalent bond with a conserved cysteine located within the unique deep hydrophobic palmitate-binding pocket of TEADs.
Thu Mar 21 00:00:00 EDT 2019
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren.
Biomolecules
Castañeda-Zegarra S,Huse C,Røsand Ø,Sarno A,Xing M,Gago-Fuentes R,Zhang Q,Alirezaylavasani A,Werner J,Ji P,Liabakk NB,Wang W,Bjørås M,Oksenych V
AF-100-15 was used in Cell Culture to determine the physiological role of Mri in DNA repair and development.
Thu Nov 28 00:00:00 EST 2019
The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.
Nature
Chang L,Azzolin L,Di Biagio D,Zanconato F,Battilana G,Lucon Xiccato R,Aragona M,Giulitti S,Panciera T,Gandin A,Sigismondo G,Krijgsveld J,Fassan M,Brusatin G,Cordenonsi M,Piccolo S
Thu Nov 01 00:00:00 EDT 2018
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.
Nature
Tauriello DVF,Palomo-Ponce S,Stork D,Berenguer-Llergo A,Badia-Ramentol J,Iglesias M,Sevillano M,Ibiza S,Cañellas A,Hernando-Momblona X,Byrom D,Matarin JA,Calon A,Rivas EI,Nebreda AR,Riera A,Attolini CS,Batlle E
Thu Feb 22 00:00:00 EST 2018
Required growth facilitators propel axon regeneration across complete spinal cord injury.
Nature
Anderson MA,O'Shea TM,Burda JE,Ao Y,Barlatey SL,Bernstein AM,Kim JH,James ND,Rogers A,Kato B,Wollenberg AL,Kawaguchi R,Coppola G,Wang C,Deming TJ,He Z,Courtine G,Sofroniew MV
Sat Sep 01 00:00:00 EDT 2018
Required growth facilitators propel axon regeneration across complete spinal cord injury.
Nature
Anderson MA,O'Shea TM,Burda JE,Ao Y,Barlatey SL,Bernstein AM,Kim JH,James ND,Rogers A,Kato B,Wollenberg AL,Kawaguchi R,Coppola G,Wang C,Deming TJ,He Z,Courtine G,Sofroniew MV
Sat Sep 01 00:00:00 EDT 2018
Intra-tumour diversification in colorectal cancer at the single-cell level.
Nature
Roerink SF,Sasaki N,Lee-Six H,Young MD,Alexandrov LB,Behjati S,Mitchell TJ,Grossmann S,Lightfoot H,Egan DA,Pronk A,Smakman N,van Gorp J,Anderson E,Gamble SJ,Alder C,van de Wetering M,Campbell PJ,Stratton MR,Clevers H
Sun Apr 01 00:00:00 EDT 2018
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.
Nature
Sulli G,Rommel A,Wang X,Kolar MJ,Puca F,Saghatelian A,Plikus MV,Verma IM,Panda S
Thu Jan 18 00:00:00 EST 2018
A metabolic function of FGFR3-TACC3 gene fusions in cancer.
Nature
Frattini V,Pagnotta SM,Fan JJ,Russo MV,Lee SB,Garofano L,Zhang J,Shi P,Lewis G,Sanson H,Frederick V,Castano AM,Cerulo L,Rolland DCM,Mall R,Mokhtari K,Elenitoba-Johnson KSJ,Sanson M,Huang X,Ceccarelli M,Lasorella A,Iavarone A
Thu Jan 11 00:00:00 EST 2018
SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X.
Cell
Wang CY,Jégu T,Chu HP,Oh HJ,Lee JT
Thu Jul 12 00:00:00 EDT 2018
Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.
Cell
Silva CG,Peyre E,Adhikari MH,Tielens S,Tanco S,Van Damme P,Magno L,Krusy N,Agirman G,Magiera MM,Kessaris N,Malgrange B,Andrieux A,Janke C,Nguyen L
AF-100-15 was used in Tissue/organ culture to demonstrate that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons.
Thu Feb 22 00:00:00 EST 2018
The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis.
Cell
de la Torre-Ubieta L,Stein JL,Won H,Opland CK,Liang D,Lu D,Geschwind DH
Thu Jan 11 00:00:00 EST 2018
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.
Cell
Hu H,Gehart H,Artegiani B,LÖpez-Iglesias C,Dekkers F,Basak O,van Es J,Chuva de Sousa Lopes SM,Begthel H,Korving J,van den Born M,Zou C,Quirk C,Chiriboga L,Rice CM,Ma S,Rios A,Peters PJ,de Jong YP,Clevers H
AF-100-15 was used in Cell Culture to establish hepatocyte proliferative pathways in organoid cultures.
Thu Nov 29 00:00:00 EST 2018
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.
Cell
Kinchen J,Chen HH,Parikh K,Antanaviciute A,Jagielowicz M,Fawkner-Corbett D,Ashley N,Cubitt L,Mellado-Gomez E,Attar M,Sharma E,Wills Q,Bowden R,Richter FC,Ahern D,Puri KD,Henault J,Gervais F,Koohy H,Simmons A
Thu Oct 04 00:00:00 EDT 2018
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Cell
Sachs N,de Ligt J,Kopper O,Gogola E,Bounova G,Weeber F,Balgobind AV,Wind K,Gracanin A,Begthel H,Korving J,van Boxtel R,Duarte AA,Lelieveld D,van Hoeck A,Ernst RF,Blokzijl F,Nijman IJ,Hoogstraat M,van de Ven M,Egan DA,Zinzalla V,Moll J,Boj SF,Voest EE,Wessels L,van Diest PJ,Rottenberg S,Vries RGJ,Cuppen E,Clevers H
Thu Jan 11 00:00:00 EST 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
Generation and post-injury integration of human spinal cord neural stem cells.
Nature methods
Kumamaru H,Kadoya K,Adler AF,Takashima Y,Graham L,Coppola G,Tuszynski MH
Sat Sep 01 00:00:00 EDT 2018
Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors.
Cancer cell
Pavlyukov MS,Yu H,Bastola S,Minata M,Shender VO,Lee Y,Zhang S,Wang J,Komarova S,Wang J,Yamaguchi S,Alsheikh HA,Shi J,Chen D,Mohyeldin A,Kim SH,Shin YJ,Anufrieva K,Evtushenko EG,Antipova NV,Arapidi GP,Govorun V,Pestov NB,Shakhparonov MI,Lee LJ,Nam DH,Nakano I
Mon Jul 09 00:00:00 EDT 2018
A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer.
Cancer cell
Peng X,Xu X,Wang Y,Hawke DH,Yu S,Han L,Zhou Z,Mojumdar K,Jeong KJ,Labrie M,Tsang YH,Zhang M,Lu Y,Hwu P,Scott KL,Liang H,Mills GB
Mon May 14 00:00:00 EDT 2018
NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.
Cancer cell
Garancher A,Lin CY,Morabito M,Richer W,Rocques N,Larcher M,Bihannic L,Smith K,Miquel C,Leboucher S,Herath NI,Dupuy F,Varlet P,Haberler C,Walczak C,El Tayara N,Volk A,Puget S,Doz F,Delattre O,Druillennec S,Ayrault O,Wechsler-Reya RJ,Eychène A,Bourdeaut F,Northcott PA,Pouponnot C
Mon Mar 12 00:00:00 EDT 2018
NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.
Cancer cell
Garancher A,Lin CY,Morabito M,Richer W,Rocques N,Larcher M,Bihannic L,Smith K,Miquel C,Leboucher S,Herath NI,Dupuy F,Varlet P,Haberler C,Walczak C,El Tayara N,Volk A,Puget S,Doz F,Delattre O,Druillennec S,Ayrault O,Wechsler-Reya RJ,Eychène A,Bourdeaut F,Northcott PA,Pouponnot C
Mon Mar 12 00:00:00 EDT 2018
Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.
Cancer cell
Takahashi N,Chen HY,Harris IS,Stover DG,Selfors LM,Bronson RT,Deraedt T,Cichowski K,Welm AL,Mori Y,Mills GB,Brugge JS
Mon Jun 11 00:00:00 EDT 2018
Growth of Epithelial Organoids in a Defined Hydrogel.
Advanced materials (Deerfield Beach, Fla.)
Broguiere N,Isenmann L,Hirt C,Ringel T,Placzek S,Cavalli E,Ringnalda F,Villiger L,Züllig R,Lehmann R,Rogler G,Heim MH,Schüler J,Zenobi-Wong M,Schwank G
Mon Oct 01 00:00:00 EDT 2018
Growth of Epithelial Organoids in a Defined Hydrogel.
Advanced materials (Deerfield Beach, Fla.)
Broguiere N,Isenmann L,Hirt C,Ringel T,Placzek S,Cavalli E,Ringnalda F,Villiger L,Züllig R,Lehmann R,Rogler G,Heim MH,Schüler J,Zenobi-Wong M,Schwank G
Mon Oct 01 00:00:00 EDT 2018
Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.
Cell stem cell
Peruzzotti-Jametti L,Bernstock JD,Vicario N,Costa ASH,Kwok CK,Leonardi T,Booty LM,Bicci I,Balzarotti B,Volpe G,Mallucci G,Manferrari G,Donegà M,Iraci N,Braga A,Hallenbeck JM,Murphy MP,Edenhofer F,Frezza C,Pluchino S
AF-100-15 was used in Cell Culture to deterimne a role for the succinate-SUCNR1 axis in somatic and directly induced neural stem cells to inflammatory metabolic signals released by type 1 MPs in the chronically inflamed-brain.
Thu Mar 01 00:00:00 EST 2018
Human Brain Organoids on a Chip Reveal the Physics of Folding.
Nature physics
Karzbrun E,Kshirsagar A,Cohen SR,Hanna JH,Reiner O
Tue May 01 00:00:00 EDT 2018
TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer.
The Journal of clinical investigation
Gong K,Guo G,Gerber DE,Gao B,Peyton M,Huang C,Minna JD,Hatanpaa KJ,Kernstine K,Cai L,Xie Y,Zhu H,Fattah FJ,Zhang S,Takahashi M,Mukherjee B,Burma S,Dowell J,Dao K,Papadimitrakopoulou VA,Olivas V,Bivona TG,Zhao D,Habib AA
Fri Jun 01 00:00:00 EDT 2018
ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
Neuron
Rousseaux MWC,Tschumperlin T,Lu HC,Lackey EP,Bondar VV,Wan YW,Tan Q,Adamski CJ,Friedrich J,Twaroski K,Chen W,Tolar J,Henzler C,Sharma A,Bajić A,Lin T,Duvick L,Liu Z,Sillitoe RV,Zoghbi HY,Orr HT
Wed Mar 21 00:00:00 EDT 2018
FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis.
Neuron
Schäffner I,Minakaki G,Khan MA,Balta EA,Schlötzer-Schrehardt U,Schwarz TJ,Beckervordersandforth R,Winner B,Webb AE,DePinho RA,Paik J,Wurst W,Klucken J,Lie DC
Wed Sep 19 00:00:00 EDT 2018
Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.
The Journal of experimental medicine
Kanaya T,Sakakibara S,Jinnohara T,Hachisuka M,Tachibana N,Hidano S,Kobayashi T,Kimura S,Iwanaga T,Nakagawa T,Katsuno T,Kato N,Akiyama T,Sato T,Williams IR,Ohno H
Mon Feb 05 00:00:00 EST 2018
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.
The Journal of experimental medicine
Chheda ZS,Kohanbash G,Okada K,Jahan N,Sidney J,Pecoraro M,Yang X,Carrera DA,Downey KM,Shrivastav S,Liu S,Lin Y,Lagisetti C,Chuntova P,Watchmaker PB,Mueller S,Pollack IF,Rajalingam R,Carcaboso AM,Mann M,Sette A,Garcia KC,Hou Y,Okada H
Tue Jan 02 00:00:00 EST 2018
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.
The Journal of experimental medicine
Chheda ZS,Kohanbash G,Okada K,Jahan N,Sidney J,Pecoraro M,Yang X,Carrera DA,Downey KM,Shrivastav S,Liu S,Lin Y,Lagisetti C,Chuntova P,Watchmaker PB,Mueller S,Pollack IF,Rajalingam R,Carcaboso AM,Mann M,Sette A,Garcia KC,Hou Y,Okada H
Tue Jan 02 00:00:00 EST 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 EST 2018
Itraconazole targets cell cycle heterogeneity in colorectal cancer.
The Journal of experimental medicine
Buczacki SJA,Popova S,Biggs E,Koukorava C,Buzzelli J,Vermeulen L,Hazelwood L,Francies H,Garnett MJ,Winton DJ
Mon Jul 02 00:00:00 EDT 2018
Selective depletion of metastatic stem cells as therapy for human colorectal cancer.
EMBO molecular medicine
Céspedes MV,Unzueta U,Aviñó A,Gallardo A,Álamo P,Sala R,Sánchez-Chardi A,Casanova I,Mangues MA,Lopez-Pousa A,Eritja R,Villaverde A,Vázquez E,Mangues R
Mon Oct 01 00:00:00 EDT 2018
Selective depletion of metastatic stem cells as therapy for human colorectal cancer.
EMBO molecular medicine
Céspedes MV,Unzueta U,Aviñó A,Gallardo A,Álamo P,Sala R,Sánchez-Chardi A,Casanova I,Mangues MA,Lopez-Pousa A,Eritja R,Villaverde A,Vázquez E,Mangues R
Mon Oct 01 00:00:00 EDT 2018
Post-translational modification of OCT4 in breast cancer tumorigenesis.
Cell death and differentiation
Cho Y,Kang HG,Kim SJ,Lee S,Jee S,Ahn SG,Kang MJ,Song JS,Chung JY,Yi EC,Chun KH
Thu Nov 01 00:00:00 EDT 2018
The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer.
Cell death and differentiation
Fernandez HR,Gadre SM,Tan M,Graham GT,Mosaoa R,Ongkeko MS,Kim KA,Riggins RB,Parasido E,Petrini I,Pacini S,Cheema A,Varghese R,Ressom HW,Zhang Y,Albanese C,Üren A,Paige M,Giaccone G,Avantaggiati ML
Sun Jul 01 00:00:00 EDT 2018
Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.
PLoS biology
Huang S,Park J,Qiu C,Chung KW,Li SY,Sirin Y,Han SH,Taylor V,Zimber-Strobl U,Susztak K
AF-100-15 was used in Cell Culture to study that JAG1 and NOTCH2 show the strongest correlation with the degree of interstitial fibrosis in a genome-wide expression analysis of a large cohort of human kidney samples.
Sat Sep 01 00:00:00 EDT 2018
Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.
Science signaling
Jones DS,Jenney AP,Joughin BA,Sorger PK,Lauffenburger DA
AF-100-15 was used in In vitro experiments to investigate signaling pathways in rheumatoid arthritis.
Tue Mar 06 00:00:00 EST 2018
LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.
British journal of cancer
Morgan RG,Mortensson E,Legge DN,Gupta B,Collard TJ,Greenhough A,Williams AC
Tue Feb 20 00:00:00 EST 2018
Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.
British journal of cancer
Maia ARR,Linder S,Song JY,Vaarting C,Boon U,Pritchard CEJ,Velds A,Huijbers IJ,van Tellingen O,Jonkers J,Medema RH
Fri Jun 01 00:00:00 EDT 2018
Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1.
Oncogene
Al Shareef Z,Kardooni H,Murillo-Garzón V,Domenici G,Stylianakis E,Steel JH,Rabano M,Gorroño-Etxebarria I,Zabalza I,Vivanco MD,Waxman J,Kypta RM
Sat Sep 01 00:00:00 EDT 2018
ING5 activity in self-renewal of glioblastoma stem cells via calcium and follicle stimulating hormone pathways.
Oncogene
Wang F,Wang AY,Chesnelong C,Yang Y,Nabbi A,Thalappilly S,Alekseev V,Riabowol K
Thu Jan 18 00:00:00 EST 2018
SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks.
The Journal of cell biology
Roy S,Luzwick JW,Schlacher K
Mon Apr 02 00:00:00 EDT 2018
Influencing the Fate of Cardiac and Neural Stem Cell Differentiation Using Small Molecule Inhibitors of ALK5.
Stem cells translational medicine
Zhong Q,Laco F,Liao MC,Woo TL,Oh SKW,Chai CLL
Mon Oct 01 00:00:00 EDT 2018
Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production.
Stem cells translational medicine
Brick RM,Sun AX,Tuan RS
Mon Jan 01 00:00:00 EST 2018
ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy.
Oncogenesis
Veenstra VL,Damhofer H,Waasdorp C,van Rijssen LB,van de Vijver MJ,Dijk F,Wilmink HW,Besselink MG,Busch OR,Chang DK,Bailey PJ,Biankin AV,Kocher HM,Medema JP,Li JS,Jiang R,Pierce DW,van Laarhoven HWM,Bijlsma MF
Fri Nov 16 00:00:00 EST 2018
Cigarette smoke stimulates the stemness of renal cancer stem cells via Sonic Hedgehog pathway.
Oncogenesis
Qian W,Kong X,Zhang T,Wang D,Song J,Li Y,Li X,Geng H,Min J,Kong Q,Liu J,Liu Z,Wang D,Zhang Z,Yu D,Zhong C
Tue Mar 13 00:00:00 EDT 2018
Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.
Journal of cellular physiology
Fritz AJ,Ghule PN,Boyd JR,Tye CE,Page NA,Hong D,Shirley DJ,Weinheimer AS,Barutcu AR,Gerrard DL,Frietze S,van Wijnen AJ,Zaidi SK,Imbalzano AN,Lian JB,Stein JL,Stein GS
AF-100-15 was used in Cell Culture to conduct gene expression and chromatin structure analysis in breast cancer on human MCF10A cells.
Thu Feb 01 00:00:00 EST 2018
Selective expression of long non-coding RNAs in a breast cancer cell progression model.
Journal of cellular physiology
Tracy KM,Tye CE,Page NA,Fritz AJ,Stein JL,Lian JB,Stein GS
AF-100-15 was used in Cell Culture to perform profiling of breast cancer cell lines that represent disease progression using transcriptome wide sequencing to identify long non-coding RNAs (lncRNAs) and their contribution to breast cancer progression.
Thu Feb 01 00:00:00 EST 2018
Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts.
The Journal of clinical endocrinology and metabolism
Marlow LA,Rohl SD,Miller JL,Knauf JA,Fagin JA,Ryder M,Milosevic D,Netzel BC,Grebe SK,Reddi HV,Smallridge RC,Copland JA
AF-100-15 was used in Cell Culture to create a standardised approach for cell line and patient-derived tumour xenograft characterisation to make valid preclinical models for thyroid cancer research.
Sat Sep 01 00:00:00 EDT 2018
Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.
Journal of leukocyte biology
Kirchmeyer M,Servais FA,Hamdorf M,Nazarov PV,Ginolhac A,Halder R,Vallar L,Glanemann M,Rubie C,Lammert F,Kreis S,Behrmann I
Thu Nov 01 00:00:00 EDT 2018
Prior Treatment with Anti-High Mobility Group Box-1 Antibody Boosts Human Neural Stem Cell Transplantation-Mediated Functional Recovery After Spinal Cord Injury.
Stem cells (Dayton, Ohio)
Uezono N,Zhu Y,Fujimoto Y,Yasui T,Matsuda T,Nakajo M,Abematsu M,Setoguchi T,Mori S,Takahashi HK,Komiya S,Nishibori M,Nakashima K
Tue May 01 00:00:00 EDT 2018
FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids.
Journal of cell science
Hosseini ZF,Nelson DA,Moskwa N,Sfakis LM,Castracane J,Larsen M
AF-100-15 was used in Cell Culture to study the requirement for mesenchymal cells and other factors in producing salivary organoids in culture to show that the basement membrane proteins and mesenchyme cells function as niche factors in salivary organoids.
Tue Feb 20 00:00:00 EST 2018
Transplanted enteric neural stem cells integrate within the developing chick spinal cord: implications for spinal cord repair.
Journal of anatomy
Jevans B,McCann CJ,Thapar N,Burns AJ
Thu Nov 01 00:00:00 EDT 2018
Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2.
Cell death & disease
Zhang X,Liu X,Zhou W,Yang M,Ding Y,Wang Q,Hu R
Wed Feb 07 00:00:00 EST 2018
Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2.
Cell death & disease
Zhang X,Liu X,Zhou W,Yang M,Ding Y,Wang Q,Hu R
Wed Feb 07 00:00:00 EST 2018
G3BP1 promotes tumor progression and metastasis through IL-6/G3BP1/STAT3 signaling axis in renal cell carcinomas.
Cell death & disease
Wang Y,Fu D,Chen Y,Su J,Wang Y,Li X,Zhai W,Niu Y,Yue D,Geng H
Tue May 01 00:00:00 EDT 2018
Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.
Nature communications
Russo M,Lamba S,Lorenzato A,Sogari A,Corti G,Rospo G,Mussolin B,Montone M,Lazzari L,Arena S,Oddo D,Linnebacher M,Sartore-Bianchi A,Pietrantonio F,Siena S,Di Nicolantonio F,Bardelli A
Tue Jun 12 00:00:00 EDT 2018
SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α.
Nature communications
Mira E,Carmona-Rodríguez L,Pérez-Villamil B,Casas J,Fernández-Aceñero MJ,Martínez-Rey D,Martín-González P,Heras-Murillo I,Paz-Cabezas M,Tardáguila M,Oury TD,Martín-Puig S,Lacalle RA,Fabriás G,Díaz-Rubio E,Mañes S
Thu Feb 08 00:00:00 EST 2018
Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.
Scientific reports
Acosta MI,Urbach S,Doye A,Ng YW,Boudeau J,Mettouchi A,Debant A,Manser E,Visvikis O,Lemichez E
Tue Jan 23 00:00:00 EST 2018
MiR-205-5p inhibition by locked nucleic acids impairs metastatic potential of breast cancer cells.
Cell death & disease
De Cola A,Lamolinara A,Lanuti P,Rossi C,Iezzi M,Marchisio M,Todaro M,De Laurenzi V
Thu Jul 26 00:00:00 EDT 2018
Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro.
Scientific reports
Schweiger PJ,Clement DL,Page ME,Schepeler T,Zou X,Sirokmány G,Watt FM,Jensen KB
Mon Oct 15 00:00:00 EDT 2018
Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1.
Cell death & disease
Kowalski-Chauvel A,Modesto A,Gouaze-Andersson V,Baricault L,Gilhodes J,Delmas C,Lemarie A,Toulas C,Cohen-Jonathan-Moyal E,Seva C
Wed Aug 29 00:00:00 EDT 2018
PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer.
Cell death & disease
Wang Q,Shi YL,Zhou K,Wang LL,Yan ZX,Liu YL,Xu LL,Zhao SW,Chu HL,Shi TT,Ma QH,Bi J
Tue Jul 03 00:00:00 EDT 2018
Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer.
Cell death & disease
Li H,Liu L,Chang H,Zou Z,Xing D
Fri Jan 26 00:00:00 EST 2018
Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity.
Cell death discovery
Li YW,Xu J,Zhu GY,Huang ZJ,Lu Y,Li XQ,Wang N,Zhang FX
Wed Sep 30 00:00:00 EDT 2020
Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance.
Cell death & disease
Yan B,Liu S,Shi Y,Liu N,Chen L,Wang X,Xiao D,Liu X,Mao C,Jiang Y,Lai W,Xin X,Tang CE,Luo D,Tan T,Jia J,Liu Y,Yang R,Huang J,Zhou H,Cheng Y,Cao Y,Yu W,Muegge K,Tao Y
Tue May 01 00:00:00 EDT 2018
Discovery of a drug candidate for GLIS3-associated diabetes.
Nature communications
Amin S,Cook B,Zhou T,Ghazizadeh Z,Lis R,Zhang T,Khalaj M,Crespo M,Perera M,Xiang JZ,Zhu Z,Tomishima M,Liu C,Naji A,Evans T,Huangfu D,Chen S
Wed Jul 11 00:00:00 EDT 2018
A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation.
Nature communications
Baumdick M,Gelléri M,Uttamapinant C,Beránek V,Chin JW,Bastiaens PIH
Fri Sep 21 00:00:00 EDT 2018
Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival.
Scientific reports
Sana J,Busek P,Fadrus P,Besse A,Radova L,Vecera M,Reguli S,Stollinova Sromova L,Hilser M,Lipina R,Lakomy R,Kren L,Smrcka M,Sedo A,Slaby O
Mon Feb 12 00:00:00 EST 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 EDT 2018
A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors.
Cell reports
Wu J,Matthias N,Lo J,Ortiz-Vitali JL,Shieh AW,Wang SH,Darabi R
AF-100-15 was used in Sample Preparation (FC/FACS) to study myogenic differentiation of human pluripotent stem cells using double-reporter cell resource and defined an improved myogenic differentiation and purification strategy.
Tue Nov 13 00:00:00 EST 2018
Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.
eLife
Balboa D,Saarimäki-Vire J,Borshagovski D,Survila M,Lindholm P,Galli E,Eurola S,Ustinov J,Grym H,Huopio H,Partanen J,Wartiovaara K,Otonkoski T
AF-100-15 was used in In vitro experiments to demonstrate that misfolded proinsulin impairs developing beta-cell proliferation without increasing apoptosis.
Fri Nov 09 00:00:00 EST 2018
Piperonylic acid stimulates keratinocyte growth and survival by activating epidermal growth factor receptor (EGFR).
Scientific reports
Lee D,Lim J,Woo KC,Kim KT
Tue Jan 09 00:00:00 EST 2018
HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations.
Scientific reports
Müller S,Djudjaj S,Lange J,Iacovescu M,Goppelt-Struebe M,Boor P
Fri Jun 22 00:00:00 EDT 2018
Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway.
Cell death & disease
Wang L,Dong X,Ren Y,Luo J,Liu P,Su D,Yang X
Fri Jan 26 00:00:00 EST 2018
Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites.
Cell death & disease
Xie Y,Zhang H,Guo XJ,Feng YC,He RZ,Li X,Yu S,Zhao Y,Shen M,Zhu F,Wang X,Wang M,Balakrishnan A,Ott M,Peng F,Qin RY
Wed Feb 14 00:00:00 EST 2018
Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents.
PloS one
Southard SM,Kotipatruni RP,Rust WL
AF-100-15 was used in Cell Culture to show that SR1423 is a candidate cell line for the production of insulin-producing cells useful for the treatment of diabetes.
Thu Feb 21 00:00:00 EST 2019
Automated in situ chromatin profiling efficiently resolves cell types and gene regulatory programs.
Epigenetics & chromatin
Janssens DH,Wu SJ,Sarthy JF,Meers MP,Myers CH,Olson JM,Ahmad K,Henikoff S
AF-100-15 was used in Cell Culture to investigate CUTRUN in gene regulation.
Fri Dec 21 00:00:00 EST 2018
Stem cells in middle ear cholesteatoma contribute to its pathogenesis.
Scientific reports
Nagel J,Wöllner S,Schürmann M,Brotzmann V,Müller J,Greiner JF,Goon P,Kaltschmidt B,Kaltschmidt C,Sudhoff H
Wed Apr 18 00:00:00 EDT 2018
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.
Nature communications
Logue SE,McGrath EP,Cleary P,Greene S,Mnich K,Almanza A,Chevet E,Dwyer RM,Oommen A,Legembre P,Godey F,Madden EC,Leuzzi B,Obacz J,Zeng Q,Patterson JB,Jäger R,Gorman AM,Samali A
Wed Aug 15 00:00:00 EDT 2018
High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway.
Scientific reports
Xue X,Chen X,Fan W,Wang G,Zhang L,Chen Z,Liu P,Liu M,Zhao J
Wed Mar 14 00:00:00 EDT 2018
Pathway crosstalk enables cells to interpret TGF-β duration.
NPJ systems biology and applications
Zhang J,Tian XJ,Chen YJ,Wang W,Watkins S,Xing J
Wed Nov 20 00:00:00 EST 2019
Assembly of fibronectin fibrils selectively attenuates platelet-derived growth factor-induced intracellular calcium release in fibroblasts.
The Journal of biological chemistry
Farrar CS,Hocking DC
Fri Nov 30 00:00:00 EST 2018
3D bio-printed scaffold-free nerve constructs with human gingiva-derived mesenchymal stem cells promote rat facial nerve regeneration.
Scientific reports
Zhang Q,Nguyen PD,Shi S,Burrell JC,Cullen DK,Le AD
Thu Apr 26 00:00:00 EDT 2018
Ub-ProT reveals global length and composition of protein ubiquitylation in cells.
Nature communications
Tsuchiya H,Burana D,Ohtake F,Arai N,Kaiho A,Komada M,Tanaka K,Saeki Y
Tue Feb 06 00:00:00 EST 2018
Ex vivo biomechanical characterization of syringe-needle ejections for intracerebral cell delivery.
Scientific reports
Wahlberg B,Ghuman H,Liu JR,Modo M
Fri Jun 15 00:00:00 EDT 2018
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Nature communications
Bayrer JR,Wang H,Nattiv R,Suzawa M,Escusa HS,Fletterick RJ,Klein OD,Moore DD,Ingraham HA
Wed Oct 10 00:00:00 EDT 2018
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Nature communications
Bayrer JR,Wang H,Nattiv R,Suzawa M,Escusa HS,Fletterick RJ,Klein OD,Moore DD,Ingraham HA
Wed Oct 10 00:00:00 EDT 2018
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.
Nature communications
Decaesteker B,Denecker G,Van Neste C,Dolman EM,Van Loocke W,Gartlgruber M,Nunes C,De Vloed F,Depuydt P,Verboom K,Rombaut D,Loontiens S,De Wyn J,Kholosy WM,Koopmans B,Essing AHW,Herrmann C,Dreidax D,Durinck K,Deforce D,Van Nieuwerburgh F,Henssen A,Versteeg R,Boeva V,Schleiermacher G,van Nes J,Mestdagh P,Vanhauwaert S,Schulte JH,Westermann F,Molenaar JJ,De Preter K,Speleman F
Mon Nov 19 00:00:00 EST 2018
Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon.
Scientific reports
Sharick JT,Favreau PF,Gillette AA,Sdao SM,Merrins MJ,Skala MC
Tue Apr 03 00:00:00 EDT 2018
Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors.
Nature communications
Urbani L,Camilli C,Phylactopoulos DE,Crowley C,Natarajan D,Scottoni F,Maghsoudlou P,McCann CJ,Pellegata AF,Urciuolo A,Deguchi K,Khalaf S,Aruta SF,Signorelli MC,Kiely D,Hannon E,Trevisan M,Wong RR,Baradez MO,Moulding D,Virasami A,Gjinovci A,Loukogeorgakis S,Mantero S,Thapar N,Sebire N,Eaton S,Lowdell M,Cossu G,Bonfanti P,De Coppi P
Tue Oct 16 00:00:00 EDT 2018
Renal cancer: new models and approach for personalizing therapy.
Journal of experimental & clinical cancer research : CR
di Martino S,De Luca G,Grassi L,Federici G,Alfonsi R,Signore M,Addario A,De Salvo L,Francescangeli F,Sanchez M,Tirelli V,Muto G,Sperduti I,Sentinelli S,Costantini M,Pasquini L,Milella M,Haoui M,Simone G,Gallucci M,De Maria R,Bonci D
AF-100-15 was used in Cell Culture to investigate clear cell renal cancer therapeutic options.
Wed Sep 05 00:00:00 EDT 2018
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
Cell reports
Somerville TDD,Xu Y,Miyabayashi K,Tiriac H,Cleary CR,Maia-Silva D,Milazzo JP,Tuveson DA,Vakoc CR
AF-100-15 was used in Cell Culture to investigate the effects of transcription factor TP63 expression and reprogramming on pancreatic ductal adenocarcinoma.
Tue Nov 13 00:00:00 EST 2018
Plasma-derived Exosomes Reverse Epithelial-to-Mesenchymal Transition after Photodynamic Therapy of Patients with Head and Neck Cancer.
Oncoscience
Theodoraki MN,Yerneni SS,Brunner C,Theodorakis J,Hoffmann TK,Whiteside TL
AF-100-15 was used in In vitro experiments to illustrate the role of exosomes as non-invasive tumor biomarker, and as the key mediator in reversing epithelial-to-mesenchymal tumor phenotype in photodynamic therapy (PDT).
Thu Mar 01 00:00:00 EST 2018
Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle.
Journal of tissue engineering and regenerative medicine
Boularaoui SM,Abdel-Raouf KMA,Alwahab NSA,Kondash ME,Truskey GA,Teo JCM,Christoforou N
AF-100-15 was used in Cell Culture to use MYOD1 to establish its capacity to induce skeletal muscle transdifferentiation of human dermal fibroblasts under baseline conditions and reveal significant transdifferentiation improvement via transforming growth factor-β/activin signalling inhibition, canonical WNT signalling activation, receptor tyrosine kinase binding and collagen type I utilization.
Thu Feb 01 00:00:00 EST 2018
Transcriptional repressor GATA binding 1-mediated repression of SRY-box 2 expression suppresses cancer stem cell functions and tumor initiation.
The Journal of biological chemistry
Gong X,Liu W,Wu L,Ma Z,Wang Y,Yu S,Zhang J,Xie H,Wei G,Ma F,Lu L,Chen L
Fri Nov 30 00:00:00 EST 2018
Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.
Cell reports
Barros-Silva JD,Linn DE,Steiner I,Guo G,Ali A,Pakula H,Ashton G,Peset I,Brown M,Clarke NW,Bronson RT,Yuan GC,Orkin SH,Li Z,Baena E
AF-100-15 was used in Cell Culture to analyse the molecular heterogeneity in basal and luminal prostate compartments.
Tue Dec 18 00:00:00 EST 2018
Actin cytoskeleton dynamics in stem cells from autistic individuals.
Scientific reports
Griesi-Oliveira K,Suzuki AM,Alves AY,Mafra ACCN,Yamamoto GL,Ezquina S,Magalhães YT,Forti FL,Sertie AL,Zachi EC,Vadasz E,Passos-Bueno MR
Tue Jul 24 00:00:00 EDT 2018
Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib.
Scientific reports
Karademir B,Sari G,Jannuzzi AT,Musunuri S,Wicher G,Grune T,Mi J,Hacioglu-Bay H,Forsberg-Nilsson K,Bergquist J,Jung T
Mon Nov 05 00:00:00 EST 2018
Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids.
Cell death & disease
Zhang B,He Y,Xu Y,Mo F,Mi T,Shen QS,Li C,Li Y,Liu J,Wu Y,Chen G,Zhu W,Qin C,Hu B,Zhou G
Mon Jun 18 00:00:00 EDT 2018
Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.
Scientific reports
Shibata W,Kinoshita H,Hikiba Y,Sato T,Ishii Y,Sue S,Sugimori M,Suzuki N,Sakitani K,Ijichi H,Mori R,Endo I,Maeda S
Wed Apr 18 00:00:00 EDT 2018
Exploiting the tunability of stimulated emission depletion microscopy for super-resolution imaging of nuclear structures.
Nature communications
Sarmento MJ,Oneto M,Pelicci S,Pesce L,Scipioni L,Faretta M,Furia L,Dellino GI,Pelicci PG,Bianchini P,Diaspro A,Lanzanò L
Fri Aug 24 00:00:00 EDT 2018
TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.
Nature communications
Iriondo O,Liu Y,Lee G,Elhodaky M,Jimenez C,Li L,Lang J,Wang P,Yu M
Fri May 18 00:00:00 EDT 2018
Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence.
Cell reports
Miller I,Min M,Yang C,Tian C,Gookin S,Carter D,Spencer SL
AF-100-15 was used in Cell Culture to investigate Ki67 in quiescence.
Tue Jul 31 00:00:00 EDT 2018
A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.
Cell reports
Smith BA,Balanis NG,Nanjundiah A,Sheu KM,Tsai BL,Zhang Q,Park JW,Thompson M,Huang J,Witte ON,Graeber TG
AF-100-15 was used in Cell Culture to develop gene signatures for normal human stem cell populations to understand the relationship between epithelial cancers and stem cell transcriptional programs to better understand how aggressive cancer phenotypes involve aspects of stem cell biology.
Tue Sep 18 00:00:00 EDT 2018
Urine-derived cells provide a readily accessible cell type for feeder-free mRNA reprogramming.
Scientific reports
Gaignerie A,Lefort N,Rousselle M,Forest-Choquet V,Flippe L,Francois-Campion V,Girardeau A,Caillaud A,Chariau C,Francheteau Q,Derevier A,Chaubron F,Knöbel S,Gaborit N,Si-Tayeb K,David L
Tue Sep 25 00:00:00 EDT 2018
Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer.
Nature communications
Arechederra M,Daian F,Yim A,Bazai SK,Richelme S,Dono R,Saurin AJ,Habermann BH,Maina F
Wed Aug 08 00:00:00 EDT 2018
Role of extrinsic mechanical force in the development of the RA-I tactile mechanoreceptor.
Scientific reports
Pham TQ,Kawaue T,Hoshi T,Tanaka Y,Miyata T,Sano A
Mon Jul 23 00:00:00 EDT 2018
Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies.
Nature communications
Boyd M,Thodberg M,Vitezic M,Bornholdt J,Vitting-Seerup K,Chen Y,Coskun M,Li Y,Lo BZS,Klausen P,Jan Schweiger P,Pedersen AG,Rapin N,Skovgaard K,Dahlgaard K,Andersson R,Terkelsen TB,Lilje B,Troelsen JT,Petersen AM,Jensen KB,Gögenur I,Thielsen P,Seidelin JB,Nielsen OH,Bjerrum JT,Sandelin A
Wed Apr 25 00:00:00 EDT 2018
Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis.
Scientific reports
Tawarayama H,Yamada H,Amin R,Morita-Fujimura Y,Cooper HM,Shinmyo Y,Kawata M,Ikawa S,Tanaka H
Tue Jan 16 00:00:00 EST 2018
Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.
The Journal of biological chemistry
Argenzio E,Klarenbeek J,Kedziora KM,Nahidiazar L,Isogai T,Perrakis A,Jalink K,Moolenaar WH,Innocenti M
Fri Dec 14 00:00:00 EST 2018
Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity.
The Journal of biological chemistry
Balasuriya N,Kunkel MT,Liu X,Biggar KK,Li SS,Newton AC,O'Donoghue P
Fri Jul 06 00:00:00 EDT 2018
Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3β activity.
Cell death discovery
Zhang SQ,Lin KL,Law CY,Liu B,Fu XQ,Tse WS,Wong SSM,Sze SCW,Yung KKL
Fri Oct 22 00:00:00 EDT 2021
Simultaneous Multiparameter Cellular Energy Metabolism Profiling of Small Populations of Cells.
Scientific reports
Kelbauskas L,Ashili SP,Lee KB,Zhu H,Tian Y,Meldrum DR
Mon Mar 12 00:00:00 EDT 2018
Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells.
Scientific reports
Azzarelli R,Rulands S,Nestorowa S,Davies J,Campinoti S,Gillotin S,Bonfanti P,Göttgens B,Huch M,Simons B,Philpott A
Thu Oct 18 00:00:00 EDT 2018
Human tissue-engineered skeletal muscle: a novel 3D in vitro model for drug disposition and toxicity after intramuscular injection.
Scientific reports
Gholobova D,Gerard M,Decroix L,Desender L,Callewaert N,Annaert P,Thorrez L
Wed Aug 15 00:00:00 EDT 2018
Human tissue-engineered skeletal muscle: a novel 3D in vitro model for drug disposition and toxicity after intramuscular injection.
Scientific reports
Gholobova D,Gerard M,Decroix L,Desender L,Callewaert N,Annaert P,Thorrez L
Wed Aug 15 00:00:00 EDT 2018
MiR34 inhibition induces human heart progenitor proliferation.
Cell death & disease
Iannolo G,Sciuto MR,Raffa GM,Pilato M,Conaldi PG
Tue Mar 06 00:00:00 EST 2018
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.
Nature communications
Jun HJ,Appleman VA,Wu HJ,Rose CM,Pineda JJ,Yeo AT,Delcuze B,Lee C,Gyuris A,Zhu H,Woolfenden S,Bronisz A,Nakano I,Chiocca EA,Bronson RT,Ligon KL,Sarkaria JN,Gygi SP,Michor F,Mitchison TJ,Charest A
Mon Aug 06 00:00:00 EDT 2018
Integrating in vitro experiments with in silico approaches for Glioblastoma invasion: the role of cell-to-cell adhesion heterogeneity.
Scientific reports
Oraiopoulou ME,Tzamali E,Tzedakis G,Liapis E,Zacharakis G,Vakis A,Papamatheakis J,Sakkalis V
Thu Nov 01 00:00:00 EDT 2018
The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration.
Scientific reports
Sánchez-Botet A,Gasa L,Quandt E,Hernández-Ortega S,Jiménez J,Mezquita P,Carrasco-García MÀ,Kron SJ,Vidal A,Villanueva A,Ribeiro MPC,Clotet J
Tue Aug 07 00:00:00 EDT 2018
Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts.
Scientific reports
Patel B,Xu Z,Pinnock CB,Kabbani LS,Lam MT
Mon Feb 19 00:00:00 EST 2018
M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia.
Cell death & disease
Sheng J,Yang Y,Cui Y,He S,Wang L,Liu L,He Q,Lv T,Han W,Yu W,Hu S,Jin J
Mon Jul 09 00:00:00 EDT 2018
Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway.
The Journal of biological chemistry
Li X,Shang E,Dong Q,Li Y,Zhang J,Xu S,Zhao Z,Shao W,Lv C,Zheng Y,Wang H,Lei X,Zhu B,Zhang Z
Fri May 11 00:00:00 EDT 2018
Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway.
The Journal of biological chemistry
Li X,Shang E,Dong Q,Li Y,Zhang J,Xu S,Zhao Z,Shao W,Lv C,Zheng Y,Wang H,Lei X,Zhu B,Zhang Z
Fri May 11 00:00:00 EDT 2018
ALCAM+ stromal cells: role in giant cell tumor of bone progression.
Cell death & disease
Zhou Z,Li Y,Wang X,Hu J,Kuang M,Wang Z,Li S,Xu W,Xiao J
Tue Feb 20 00:00:00 EST 2018
VDAC2 interacts with PFKP to regulate glucose metabolism and phenotypic reprogramming of glioma stem cells.
Cell death & disease
Zhou K,Yao YL,He ZC,Chen C,Zhang XN,Yang KD,Liu YQ,Liu Q,Fu WJ,Chen YP,Niu Q,Ma QH,Zhou R,Yao XH,Zhang X,Cui YH,Bian XW,Shi Y,Ping YF
Mon Sep 24 00:00:00 EDT 2018
Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
Nature communications
Kang MH,Choi H,Oshima M,Cheong JH,Kim S,Lee JH,Park YS,Choi HS,Kweon MN,Pack CG,Lee JS,Mills GB,Myung SJ,Park YY
Tue May 15 00:00:00 EDT 2018
Cell clustering mediated by the adhesion protein PVRL4 is necessary for α6β4 integrin-promoted ferroptosis resistance in matrix-detached cells.
The Journal of biological chemistry
Brown CW,Amante JJ,Mercurio AM
Fri Aug 17 00:00:00 EDT 2018
Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells.
Cell death discovery
Chung SY,Chen YH,Lin PR,Chao TC,Su JC,Shiau CW,Su Y
Wed Sep 30 00:00:00 EDT 2020
Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
Scientific reports
Bayó-Puxan N,Terrasso AP,Creyssels S,Simão D,Begon-Pescia C,Lavigne M,Salinas S,Bernex F,Bosch A,Kalatzis V,Levade T,Cuervo AM,Lory P,Consiglio A,Brito C,Kremer EJ
Fri Nov 09 00:00:00 EST 2018
Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4.
Nature communications
Li D,Song H,Mei H,Fang E,Wang X,Yang F,Li H,Chen Y,Huang K,Zheng L,Tong Q
Thu Jul 19 00:00:00 EDT 2018
Nanomedicines reveal how PBOV1 promotes hepatocellular carcinoma for effective gene therapy.
Nature communications
Guo Y,Wu Z,Shen S,Guo R,Wang J,Wang W,Zhao K,Kuang M,Shuai X
Fri Aug 24 00:00:00 EDT 2018
Culture and characterization of chicken small intestinal crypts.
Poultry science
Li J,Li J,Zhang SY,Li RX,Lin X,Mi YL,Zhang CQ
AF-100-15 was used in Tissue/organ culture to study the crypts of chickens small intestines.
Tue May 01 00:00:00 EDT 2018
Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.
Cell death & disease
Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q
Wed Mar 07 00:00:00 EST 2018
The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion.
Nature communications
Padilla-Rodriguez M,Parker SS,Adams DG,Westerling T,Puleo JI,Watson AW,Hill SM,Noon M,Gaudin R,Aaron J,Tong D,Roe DJ,Knudsen B,Mouneimne G
Mon Jul 30 00:00:00 EDT 2018
Replication of biocompatible, nanotopographic surfaces.
Scientific reports
Sun X,Hourwitz MJ,Baker EM,Schmidt BUS,Losert W,Fourkas JT
Fri Jan 12 00:00:00 EST 2018
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.
Nature communications
Li X,Francies HE,Secrier M,Perner J,Miremadi A,Galeano-Dalmau N,Barendt WJ,Letchford L,Leyden GM,Goffin EK,Barthorpe A,Lightfoot H,Chen E,Gilbert J,Noorani A,Devonshire G,Bower L,Grantham A,MacRae S,Grehan N,Wedge DC,Fitzgerald RC,Garnett MJ
Mon Jul 30 00:00:00 EDT 2018
MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer.
Cell death & disease
Wang QY,Zhou CX,Zhan MN,Tang J,Wang CL,Ma CN,He M,Chen GQ,He JR,Zhao Q
Tue Jul 03 00:00:00 EDT 2018
Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.
Nature communications
Shiota M,Naya M,Yamamoto T,Hishiki T,Tani T,Takahashi H,Kubo A,Koike D,Itoh M,Ohmura M,Kabe Y,Sugiura Y,Hiraoka N,Morikawa T,Takubo K,Suina K,Nagashima H,Sampetrean O,Nagano O,Saya H,Yamazoe S,Watanabe H,Suematsu M
Thu Apr 19 00:00:00 EDT 2018
miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA/BBC3 and BTG2.
Cell death & disease
Fiori ME,Villanova L,Barbini C,De Angelis ML,De Maria R
Fri Jan 19 00:00:00 EST 2018
DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/β-catenin pathway via GSK3β.
Cell death & disease
Liu XF,Li XY,Zheng PS,Yang WT
Thu Mar 01 00:00:00 EST 2018
The functional and inflammatory response of brain endothelial cells to Toll-Like Receptor agonists.
Scientific reports
Johnson RH,Kho DT,O' Carroll SJ,Angel CE,Graham ES
Wed Jul 04 00:00:00 EDT 2018
The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation.
Scientific reports
Choi CI,Yoon H,Drucker KL,Langley MR,Kleppe L,Scarisbrick IA
Tue Jun 19 00:00:00 EDT 2018
Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
Cell death & disease
Cho SH,Kuo IY,Lu PF,Tzeng HT,Lai WW,Su WC,Wang YC
Wed Aug 29 00:00:00 EDT 2018
In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity.
Cell stem cell
Zhang K,Zhang L,Liu W,Ma X,Cen J,Sun Z,Wang C,Feng S,Zhang Z,Yue L,Sun L,Zhu Z,Chen X,Feng A,Wu J,Jiang Z,Li P,Cheng X,Gao D,Peng L,Hui L
AF-100-15 was used in Cell Culture to study ideal medium conditions for human hepatocytes for proliferation in injured mouse liver.
Thu Dec 06 00:00:00 EST 2018
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Cell
Roe JS,Hwang CI,Somerville TDD,Milazzo JP,Lee EJ,Da Silva B,Maiorino L,Tiriac H,Young CM,Miyabayashi K,Filippini D,Creighton B,Burkhart RA,Buscaglia JM,Kim EJ,Grem JL,Lazenby AJ,Grunkemeyer JA,Hollingsworth MA,Grandgenett PM,Egeblad M,Park Y,Tuveson DA,Vakoc CR
AF-100-15 was used in Cell Culture to use an organoid culture system to investigate how transcription and the enhancer landscape become altered during discrete stages of disease progression in a PDA mouse model.
Thu Aug 24 00:00:00 EDT 2017
Multivalent Small-Molecule Pan-RAS Inhibitors.
Cell
Welsch ME,Kaplan A,Chambers JM,Stokes ME,Bos PH,Zask A,Zhang Y,Sanchez-Martin M,Badgley MA,Huang CS,Tran TH,Akkiraju H,Brown LM,Nandakumar R,Cremers S,Yang WS,Tong L,Olive KP,Ferrando A,Stockwell BR
Thu Feb 23 00:00:00 EST 2017
Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.
Cell
Nora EP,Goloborodko A,Valton AL,Gibcus JH,Uebersohn A,Abdennur N,Dekker J,Mirny LA,Bruneau BG
Thu May 18 00:00:00 EDT 2017
A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.
Cell
Tan SLW,Chadha S,Liu Y,Gabasova E,Perera D,Ahmed K,Constantinou S,Renaudin X,Lee M,Aebersold R,Venkitaraman AR
Thu Jun 01 00:00:00 EDT 2017
Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.
Cancer cell
Hydbring P,Wang Y,Fassl A,Li X,Matia V,Otto T,Choi YJ,Sweeney KE,Suski JM,Yin H,Bogorad RL,Goel S,Yuzugullu H,Kauffman KJ,Yang J,Jin C,Li Y,Floris D,Swanson R,Ng K,Sicinska E,Anders L,Zhao JJ,Polyak K,Anderson DG,Li C,Sicinski P
Mon Apr 10 00:00:00 EDT 2017
MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.
Cancer cell
Huang T,Kim CK,Alvarez AA,Pangeni RP,Wan X,Song X,Shi T,Yang Y,Sastry N,Horbinski CM,Lu S,Stupp R,Kessler JA,Nishikawa R,Nakano I,Sulman EP,Lu X,James CD,Yin XM,Hu B,Cheng SY
Mon Dec 11 00:00:00 EST 2017
H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.
Cancer cell
Pathania M,De Jay N,Maestro N,Harutyunyan AS,Nitarska J,Pahlavan P,Henderson S,Mikael LG,Richard-Londt A,Zhang Y,Costa JR,Hébert S,Khazaei S,Ibrahim NS,Herrero J,Riccio A,Albrecht S,Ketteler R,Brandner S,Kleinman CL,Jabado N,Salomoni P
Mon Nov 13 00:00:00 EST 2017
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.
Cancer discovery
Mathur D,Stratikopoulos E,Ozturk S,Steinbach N,Pegno S,Schoenfeld S,Yong R,Murty VV,Asara JM,Cantley LC,Parsons R
AF-100-15 was used in Cell Culture to study how the increased growth of PTEN-mutant cells is dependent on glutamine flux through the de novo pyrimidine synthesis pathway.
Sat Apr 01 00:00:00 EDT 2017
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.
The Journal of experimental medicine
Öhlund D,Handly-Santana A,Biffi G,Elyada E,Almeida AS,Ponz-Sarvise M,Corbo V,Oni TE,Hearn SA,Lee EJ,Chio II,Hwang CI,Tiriac H,Baker LA,Engle DD,Feig C,Kultti A,Egeblad M,Fearon DT,Crawford JM,Clevers H,Park Y,Tuveson DA
Mon Mar 06 00:00:00 EST 2017
A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.
The Journal of experimental medicine
Schwerd T,Twigg SRF,Aschenbrenner D,Manrique S,Miller KA,Taylor IB,Capitani M,McGowan SJ,Sweeney E,Weber A,Chen L,Bowness P,Riordan A,Cant A,Freeman AF,Milner JD,Holland SM,Frede N,Müller M,Schmidt-Arras D,Grimbacher B,Wall SA,Jones EY,Wilkie AOM,Uhlig HH
Mon Sep 04 00:00:00 EDT 2017
The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.
Developmental cell
Yellajoshyula D,Liang CC,Pappas SS,Penati S,Yang A,Mecano R,Kumaran R,Jou S,Cookson MR,Dauer WT
AF-100-15 was used in Cell Culture to study the neurodevelopmental processes in which the transcription factor, THAP1, participates in.
Mon Jul 10 00:00:00 EDT 2017
KDM4 Inhibition Targets Breast Cancer Stem-like Cells.
Cancer research
Metzger E,Stepputtis SS,Strietz J,Preca BT,Urban S,Willmann D,Allen A,Zenk F,Iovino N,Bronsert P,Proske A,Follo M,Boerries M,Stickeler E,Xu J,Wallace MB,Stafford JA,Kanouni T,Maurer J,Schüle R
AF-100-15 was used in Cell Culture to validate a BCSC culture system for drug screening and proof of concept for KDM4 inhibition as a triple-negative breast cancer treatment.
Wed Nov 01 00:00:00 EDT 2017
tsRNA signatures in cancer.
Proceedings of the National Academy of Sciences of the United States of America
Balatti V,Nigita G,Veneziano D,Drusco A,Stein GS,Messier TL,Farina NH,Lian JB,Tomasello L,Liu CG,Palamarchuk A,Hart JR,Bell C,Carosi M,Pescarmona E,Perracchio L,Diodoro M,Russo A,Antenucci A,Visca P,Ciardi A,Harris CC,Vogt PK,Pekarsky Y,Croce CM
AF-100-15 was used in Cell Culture to study how tRNA-derived small RNAs (tsRNAs) affect cell growth and survival.
Tue Jul 25 00:00:00 EDT 2017
Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts.
Proceedings of the National Academy of Sciences of the United States of America
Fior R,Póvoa V,Mendes RV,Carvalho T,Gomes A,Figueiredo N,Ferreira MG
Tue Sep 26 00:00:00 EDT 2017
Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells.
Cell death and differentiation
Piyush T,Chacko AR,Sindrewicz P,Hilkens J,Rhodes JM,Yu LG
Wed Nov 01 00:00:00 EDT 2017
Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification.
Cell death and differentiation
Vicinanza C,Aquila I,Scalise M,Cristiano F,Marino F,Cianflone E,Mancuso T,Marotta P,Sacco W,Lewis FC,Couch L,Shone V,Gritti G,Torella A,Smith AJ,Terracciano CM,Britti D,Veltri P,Indolfi C,Nadal-Ginard B,Ellison-Hughes GM,Torella D
Fri Dec 01 00:00:00 EST 2017
Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells.
Oncogene
Kawauchi D,Ogg RJ,Liu L,Shih DJH,Finkelstein D,Murphy BL,Rehg JE,Korshunov A,Calabrese C,Zindy F,Phoenix T,Kawaguchi Y,Gronych J,Gilbertson RJ,Lichter P,Gajjar A,Kool M,Northcott PA,Pfister SM,Roussel MF
Thu Sep 14 00:00:00 EDT 2017
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Oncogene
Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW
Thu Jul 13 00:00:00 EDT 2017
Differential expression of miR16 in glioblastoma and glioblastoma stem cells: their correlation with proliferation, differentiation, metastasis and prognosis.
Oncogene
Tian R,Wang J,Yan H,Wu J,Xu Q,Zhan X,Gui Z,Ding M,He J
Thu Oct 19 00:00:00 EDT 2017
Preclinical Analysis of Fetal Human Mesencephalic Neural Progenitor Cell Lines: Characterization and Safety In Vitro and In Vivo.
Stem cells translational medicine
Moon J,Schwarz SC,Lee HS,Kang JM,Lee YE,Kim B,Sung MY,Höglinger G,Wegner F,Kim JS,Chung HM,Chang SW,Cha KY,Kim KS,Schwarz J
Wed Feb 01 00:00:00 EST 2017
Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-β1.
Stem cells translational medicine
Gimeno ML,Fuertes F,Barcala Tabarrozzi AE,Attorressi AI,Cucchiani R,Corrales L,Oliveira TC,Sogayar MC,Labriola L,Dewey RA,Perone MJ
Sun Jan 01 00:00:00 EST 2017
Neural Progenitor-Like Cells Induced from Human Gingiva-Derived Mesenchymal Stem Cells Regulate Myelination of Schwann Cells in Rat Sciatic Nerve Regeneration.
Stem cells translational medicine
Zhang Q,Nguyen P,Xu Q,Park W,Lee S,Furuhashi A,Le AD
Wed Feb 01 00:00:00 EST 2017
Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells.
Stem cells translational medicine
Wang JY,Wu PK,Chen PC,Lee CW,Chen WM,Hung SC
Wed Feb 01 00:00:00 EST 2017
Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells with Distinctive Paracrine and Plasticity Properties.
Stem cells translational medicine
Chimenti I,Pagano F,Angelini F,Siciliano C,Mangino G,Picchio V,De Falco E,Peruzzi M,Carnevale R,Ibrahim M,Biondi-Zoccai G,Messina E,Frati G
Wed Mar 01 00:00:00 EST 2017
FAM83A is amplified and promotes cancer stem cell-like traits and chemoresistance in pancreatic cancer.
Oncogenesis
Chen S,Huang J,Liu Z,Liang Q,Zhang N,Jin Y
Mon Mar 13 00:00:00 EDT 2017
SOX2 is required to maintain cancer stem cells in ovarian cancer.
Cancer science
Wen Y,Hou Y,Huang Z,Cai J,Wang Z
Sat Apr 01 00:00:00 EDT 2017
A 22q11.2 amplification in the region encoding microRNA-650 correlates with the epithelial to mesenchymal transition in breast cancer primary cultures of Mexican patients.
International journal of oncology
Lango-Chavarría M,Chimal-Ramírez GK,Ruiz-Tachiquín ME,Espinoza-Sánchez NA,Suárez-Arriaga MC,Fuentes-Pananá EM
AF-100-15 was used in Cell Culture to suggests that the gain of region 22q11.2 contributes to trigger EMT. This is the first evidence linking miR-650 and breast cancer.
Wed Feb 01 00:00:00 EST 2017
Genetic Evolution of Glioblastoma Stem-Like Cells From Primary to Recurrent Tumor.
Stem cells (Dayton, Ohio)
Orzan F,De Bacco F,Crisafulli G,Pellegatta S,Mussolin B,Siravegna G,D'Ambrosio A,Comoglio PM,Finocchiaro G,Boccaccio C
Wed Nov 01 00:00:00 EDT 2017
Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-β and Furin in Glioma-Initiating Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ventura E,Weller M,Burghardt I
Thu Jun 15 00:00:00 EDT 2017
iPSC-derived mesenchymal stem cells exert SCF-dependent recovery of cigarette smoke-induced apoptosis/proliferation imbalance in airway cells.
Journal of cellular and molecular medicine
Li X,Zhang Y,Liang Y,Cui Y,Yeung SC,Ip MS,Tse HF,Lian Q,Mak JC
Wed Feb 01 00:00:00 EST 2017
The antiviral cytokine interferon-gamma restricts neural stem/progenitor cell proliferation through activation of STAT1 and modulation of retinoblastoma protein phosphorylation.
Journal of neuroscience research
Kulkarni A,Scully TJ,O'Donnell LA
Tue Aug 01 00:00:00 EDT 2017
Efficacy of Two Delivery Routes for Transplanting Human Neural Progenitor Cells (NPCs) Into the Spastic Han-Wistar Rat, a Model of Ataxia.
Cell transplantation
Uhlendorf TL,Nuryyev RL,Kopyov AO,Ochoa J,Younesi S,Cohen RW,Kopyov OV
AF-100-15 was used in Cell Culture to show that direct implantation of hNPCs reduced ataxic symptoms in the sHW rat, demonstrating that stereotactic route of stem cell delivery correlates to improved clinical outcomes.
Thu Feb 16 00:00:00 EST 2017
Long noncoding RNA ASAP1-IT1 promotes cancer stemness and predicts a poor prognosis in patients with bladder cancer.
Neoplasma
Yang L,Xue Y,Liu J,Zhuang J,Shen L,Shen B,Yan J,Guo H
AF-100-15 was used in In vitro experiments to suggest that ASAP1-IT1 plays an oncogenic role in bladder cancer and can be used as a potential prognostic and therapeutic target.
Mon Apr 29 00:00:00 EDT 2019
FAD influx enhances neuronal differentiation of human neural stem cells by facilitating nuclear localization of LSD1.
FEBS open bio
Hirano K,Namihira M
Fri Dec 01 00:00:00 EST 2017
Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction.
FEBS open bio
Kuramoto K,Suzuki S,Sakaki H,Takeda H,Sanomachi T,Seino S,Narita Y,Kayama T,Kitanaka C,Okada M
Thu Jun 01 00:00:00 EDT 2017
Pigment epithelium-derived factor short peptides facilitate full-thickness cutaneous wound healing by promoting epithelial basal cell and hair follicle stem cell proliferation.
Experimental and therapeutic medicine
Tsai SH,Tsao LP,Chang SH,Ho TC,Tung KY,Wu AC,Tsao YP
AF-100-15 was used in Cell Culture to investigate peptide fragment delivery in mouse models for wound healing.
Wed Nov 01 00:00:00 EDT 2017
Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level.
Stem cell reports
Pode-Shakked N,Gershon R,Tam G,Omer D,Gnatek Y,Kanter I,Oriel S,Katz G,Harari-Steinberg O,Kalisky T,Dekel B
Tue Jul 11 00:00:00 EDT 2017
HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells.
Nature communications
Lin Y,Fang ZP,Liu HJ,Wang LJ,Cheng Z,Tang N,Li T,Liu T,Han HX,Cao G,Liang L,Ding YQ,Zhou WJ
Fri Oct 27 00:00:00 EDT 2017
HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells.
Nature communications
Lin Y,Fang ZP,Liu HJ,Wang LJ,Cheng Z,Tang N,Li T,Liu T,Han HX,Cao G,Liang L,Ding YQ,Zhou WJ
Fri Oct 27 00:00:00 EDT 2017
Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma.
Scientific reports
Abate M,Laezza C,Pisanti S,Torelli G,Seneca V,Catapano G,Montella F,Ranieri R,Notarnicola M,Gazzerro P,Bifulco M,Ciaglia E
Thu Oct 26 00:00:00 EDT 2017
Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin.
The Journal of biological chemistry
Schmidt EGW,Hvam ML,Antunes F,Cameron J,Viuff D,Andersen B,Kristensen NN,Howard KA
Fri Aug 11 00:00:00 EDT 2017
Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production.
Cell death & disease
Zhang M,Wang J,Deng C,Jiang MH,Feng X,Xia K,Li W,Lai X,Xiao H,Ge RS,Gao Y,Xiang AP
Thu Oct 12 00:00:00 EDT 2017
BCL-XL directly modulates RAS signalling to favour cancer cell stemness.
Nature communications
Carné Trécesson S,Souazé F,Basseville A,Bernard AC,Pécot J,Lopez J,Bessou M,Sarosiek KA,Letai A,Barillé-Nion S,Valo I,Coqueret O,Guette C,Campone M,Gautier F,Juin PP
Tue Oct 24 00:00:00 EDT 2017
FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development.
Nature communications
Sahu SK,Tiwari N,Pataskar A,Zhuang Y,Borisova M,Diken M,Strand S,Beli P,Tiwari VK
Wed Nov 15 00:00:00 EST 2017
Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth.
Scientific reports
Yu NY,Bieder A,Raman A,Mileti E,Katayama S,Einarsdottir E,Fredholm BB,Falk A,Tapia-Páez I,Daub CO,Kere J
Wed Sep 13 00:00:00 EDT 2017
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.
Stem cell reports
Oksanen M,Petersen AJ,Naumenko N,Puttonen K,Lehtonen Š,Gubert Olivé M,Shakirzyanova A,Leskelä S,Sarajärvi T,Viitanen M,Rinne JO,Hiltunen M,Haapasalo A,Giniatullin R,Tavi P,Zhang SC,Kanninen KM,Hämäläinen RH,Koistinaho J
Tue Dec 12 00:00:00 EST 2017
Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons.
Scientific reports
Park J,Lee N,Lee J,Choe EK,Kim MK,Lee J,Byun MS,Chon MW,Kim SW,Lee CJ,Kim JH,Kwon JS,Chang MS
Thu Aug 31 00:00:00 EDT 2017
Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2.
Nature communications
Tsutsumi R,Harizanova J,Stockert R,Schröder K,Bastiaens PIH,Neel BG
Wed Sep 06 00:00:00 EDT 2017
Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells.
Stem cell reports
Santos R,Vadodaria KC,Jaeger BN,Mei A,Lefcochilos-Fogelquist S,Mendes APD,Erikson G,Shokhirev M,Randolph-Moore L,Fredlender C,Dave S,Oefner R,Fitzpatrick C,Pena M,Barron JJ,Ku M,Denli AM,Kerman BE,Charnay P,Kelsoe JR,Marchetto MC,Gage FH
Tue Jun 06 00:00:00 EDT 2017
HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.
Scientific reports
Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B
Thu Nov 02 00:00:00 EDT 2017
LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.
Cell death & disease
Cao HZ,Liu XF,Yang WT,Chen Q,Zheng PS
Thu Sep 07 00:00:00 EDT 2017
Therapeutic potential of human minor salivary gland epithelial progenitor cells in liver regeneration.
Scientific reports
Zhang C,Li Y,Zhang XY,Liu L,Tong HZ,Han TL,Li WD,Jin XL,Yin NB,Song T,Li HD,Zhi J,Zhao ZM,Lu L
Thu Oct 05 00:00:00 EDT 2017
Directed Differentiation of Human Bone Marrow Stromal Cells to Fate-Committed Schwann Cells.
Stem cell reports
Cai S,Tsui YP,Tam KW,Shea GK,Chang RS,Ao Q,Shum DK,Chan YS
Tue Oct 10 00:00:00 EDT 2017
Implantation of Human Peripheral Corneal Spheres into Cadaveric Human Corneal Tissue.
Bio-protocol
Mathan JJ,Ismail S,McGhee JJ,Sherwin T
AF-100-15 was used in Cell Culture to produce protocols of human corneal spheres into cadaveric human corneal tissue.
Thu Jul 20 00:00:00 EDT 2017
Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex.
Cell stem cell
Bifari F,Decimo I,Pino A,Llorens-Bobadilla E,Zhao S,Lange C,Panuccio G,Boeckx B,Thienpont B,Vinckier S,Wyns S,Bouché A,Lambrechts D,Giugliano M,Dewerchin M,Martin-Villalba A,Carmeliet P
AF-100-15 was used in In vitro experiments to identify radial glia-like cells present in the meninges that migrate and differentiate into functional neurons in the neonatal cerebral cortex.
Thu Mar 02 00:00:00 EST 2017
Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.
Nature communications
Bicker F,Vasic V,Horta G,Ortega F,Nolte H,Kavyanifar A,Keller S,Stankovic ND,Harter PN,Benedito R,Lutz B,Bäuerle T,Hartwig J,Baumgart J,Krüger M,Radyushkin K,Alberi L,Berninger B,Schmidt MHH
Wed Jun 28 00:00:00 EDT 2017
Cell Cycle Model System for Advancing Cancer Biomarker Research.
Scientific reports
Lazar IM,Hoeschele I,de Morais J,Tenga MJ
Thu Dec 21 00:00:00 EST 2017
lncTCF7 is a negative prognostic factor, and knockdown of lncTCF7 inhibits migration, proliferation and tumorigenicity in glioma.
Scientific reports
Gao X,Guo X,Xue H,Qiu W,Guo X,Zhang J,Qian M,Li T,Liu Q,Shen J,Deng L,Li G
Tue Dec 12 00:00:00 EST 2017
DLL4 overexpression increases gastric cancer stem/progenitor cell self-renewal ability and correlates with poor clinical outcome via Notch-1 signaling pathway activation.
Cancer medicine
Miao ZF,Xu H,Xu HM,Wang ZN,Zhao TT,Song YX,Xu YY
Sun Jan 01 00:00:00 EST 2017
Quantitative investigation of MDA-MB-231 breast cancer cell motility: dependence on epidermal growth factor concentration and its gradient.
Molecular bioSystems
Islam T,Resat H
AF-100-15 was used in Cell Culture to discuss the implications of our results on the total and chemotactic movement of cancer cells in the tumor microenvironment.
Tue Sep 26 00:00:00 EDT 2017
Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids.
eLife
Nikolić MZ,Caritg O,Jeng Q,Johnson JA,Sun D,Howell KJ,Brady JL,Laresgoiti U,Allen G,Butler R,Zilbauer M,Giangreco A,Rawlins EL
AF-100-15 was used in Tissue/organ culture to investigate human pluripotent stem cell differentiation to lung epithelium.
Fri Jun 30 00:00:00 EDT 2017
A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK.
Stem cell reports
Jaraíz-Rodríguez M,Tabernero MD,González-Tablas M,Otero A,Orfao A,Medina JM,Tabernero A
Tue Aug 08 00:00:00 EDT 2017
NMR Metabolomics for Stem Cell type discrimination.
Scientific reports
Castiglione F,Ferro M,Mavroudakis E,Pellitteri R,Bossolasco P,Zaccheo D,Morbidelli M,Silani V,Mele A,Moscatelli D,Cova L
Fri Nov 17 00:00:00 EST 2017
Primary patient-derived lung adenocarcinoma cell culture challenges the association of cancer stem cells with epithelial-to-mesenchymal transition.
Scientific reports
Tiran V,Lindenmann J,Brcic L,Heitzer E,Stanzer S,Tabrizi-Wizsy NG,Stacher E,Stoeger H,Popper HH,Balic M,Dandachi N
Wed Aug 30 00:00:00 EDT 2017
Elevated expression of Tie1 is accompanied by acquisition of cancer stemness properties in colorectal cancer.
Cancer medicine
Torigata M,Yamakawa D,Takakura N
Thu Jun 01 00:00:00 EDT 2017
Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells.
Cell death & disease
Pagotto A,Pilotto G,Mazzoldi EL,Nicoletto MO,Frezzini S,Pastò A,Amadori A
Thu Jul 20 00:00:00 EDT 2017
Ectodysplasin A protein promotes corneal epithelial cell proliferation.
The Journal of biological chemistry
Li S,Zhou J,Bu J,Ning K,Zhang L,Li J,Guo Y,He X,He H,Cai X,Chen Y,Reinach PS,Liu Z,Li W
Fri Aug 11 00:00:00 EDT 2017
Noninvasive Imaging of Ras Activity by Monomolecular Biosensor Based on Split-Luciferase Complementary Assay.
Scientific reports
Chen L,Leng WB,Li Z,Xia HW,Ren M,Tang QL,Gong QY,Gao FB,Bi F
Wed Aug 30 00:00:00 EDT 2017
Canonical NFκB signaling in myeloid cells is required for the glioblastoma growth.
Scientific reports
Achyut BR,Angara K,Jain M,Borin TF,Rashid MH,Iskander ASM,Ara R,Kolhe R,Howard S,Venugopal N,Rodriguez PC,Bradford JW,Arbab AS
Mon Oct 23 00:00:00 EDT 2017
Isolation, Culture and Differentiation of Adult Hippocampal Precursor Cells.
Bio-protocol
Bernas SN,Leiter O,Walker TL,Kempermann G
AF-100-15 was used in Cell Culture to describe the isolation, culturing methods and differentiation of neural precursor cells in both the neurosphere assay and monolayer culture.
Sun Nov 05 00:00:00 EDT 2017
Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway.
Cell death & disease
Sheng W,Chen C,Dong M,Wang G,Zhou J,Song H,Li Y,Zhang J,Ding S
Thu Oct 26 00:00:00 EDT 2017
SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress.
Scientific reports
Patten DA,Kamarajah SK,Rose JM,Tickle J,Shepherd EL,Adams DH,Weston CJ,Shetty S
Thu Dec 14 00:00:00 EST 2017
Investigation of brain tissue infiltration by medulloblastoma cells in an ex vivo model.
Scientific reports
Neve A,Santhana Kumar K,Tripolitsioti D,Grotzer MA,Baumgartner M
Thu Jul 13 00:00:00 EDT 2017
Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity.
Nature communications
Gutknecht MF,Seaman ME,Ning B,Cornejo DA,Mugler E,Antkowiak PF,Moskaluk CA,Hu S,Epstein FH,Kelly KA
Fri Sep 15 00:00:00 EDT 2017
Surface functionalisation of nanodiamonds for human neural stem cell adhesion and proliferation.
Scientific reports
Taylor AC,González CH,Miller BS,Edgington RJ,Ferretti P,Jackman RB
Fri Aug 04 00:00:00 EDT 2017
Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells.
Stem cell reports
Yasui T,Uezono N,Nakashima H,Noguchi H,Matsuda T,Noda-Andoh T,Okano H,Nakashima K
Tue Jun 06 00:00:00 EDT 2017
A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit.
Scientific reports
Kopinja J,Sevilla RS,Levitan D,Dai D,Vanko A,Spooner E,Ware C,Forget R,Hu K,Kral A,Spacciapoli P,Kennan R,Jayaraman L,Pucci V,Perera S,Zhang W,Fischer C,Lam MH
Mon Oct 23 00:00:00 EDT 2017
Differences in Three-Dimensional Geometric Recognition by Non-Cancerous and Cancerous Epithelial Cells on Microgroove-Based Topography.
Scientific reports
Kushiro K,Yaginuma T,Ryo A,Takai M
Mon Jun 26 00:00:00 EDT 2017
Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane.
Scientific reports
Werbin JL,Avendaño MS,Becker V,Jungmann R,Yin P,Danuser G,Sorger PK
Fri Sep 22 00:00:00 EDT 2017
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.
Nature communications
Laviolette LA,Mermoud J,Calvo IA,Olson N,Boukhali M,Steinlein OK,Roider E,Sattler EC,Huang D,Teh BT,Motamedi M,Haas W,Iliopoulos O
Wed Jun 28 00:00:00 EDT 2017
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.
Nature communications
Laviolette LA,Mermoud J,Calvo IA,Olson N,Boukhali M,Steinlein OK,Roider E,Sattler EC,Huang D,Teh BT,Motamedi M,Haas W,Iliopoulos O
Wed Jun 28 00:00:00 EDT 2017
Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models.
Scientific reports
Jain M,Gamage NH,Alsulami M,Shankar A,Achyut BR,Angara K,Rashid MH,Iskander A,Borin TF,Wenbo Z,Ara R,Ali MM,Lebedyeva I,Chwang WB,Guo A,Bagher-Ebadian H,Arbab AS
Tue Jan 31 00:00:00 EST 2017
Therapy of corneal endothelial dysfunction with corneal endothelial cell-like cells derived from skin-derived precursors.
Scientific reports
Shen L,Sun P,Zhang C,Yang L,Du L,Wu X
Tue Oct 17 00:00:00 EDT 2017
Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition.
Oncotarget
Hong D,Messier TL,Tye CE,Dobson JR,Fritz AJ,Sikora KR,Browne G,Stein JL,Lian JB,Stein GS
AF-100-15 was used in Sample Preparation to show epithelial to mesenchymal transition can be prevented by stabilisation of the epithelial cell phenotype via transcription factor Runx1.
Tue Mar 14 00:00:00 EDT 2017
Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis.
Stem cell reports
Redgrave RE,Tual-Chalot S,Davison BJ,Singh E,Hall D,Amirrasouli MM,Gilchrist D,Medvinsky A,Arthur HM
Tue May 09 00:00:00 EDT 2017
Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas.
Scientific reports
Lee HM,Joh JW,Seo SR,Kim WT,Kim MK,Choi HS,Kim SY,Jang YJ,Sinn DH,Choi GS,Kim JM,Kwon CHD,Chang HJ,Kim DS,Ryu CJ
Mon Oct 16 00:00:00 EDT 2017
STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization.
The Journal of biological chemistry
Kitai Y,Iwakami M,Saitoh K,Togi S,Isayama S,Sekine Y,Muromoto R,Kashiwakura JI,Yoshimura A,Oritani K,Matsuda T
Fri Nov 24 00:00:00 EST 2017
Entosis Is Induced by Glucose Starvation.
Cell reports
Hamann JC,Surcel A,Chen R,Teragawa C,Albeck JG,Robinson DN,Overholtzer M
AF-100-15 was used in Cell Culture to study how entosis is induced in adherent cells by glucose withdrawal to demonstrate that entosis serves as a cellular response to metabolic stress that enables nutrient recovery through neighbor cell ingestion.
Wed Jul 05 00:00:00 EDT 2017
Baicalein has protective effects on the 17β-estradiol-induced transformation of breast epithelial cells.
Oncotarget
Chen Y,Wang J,Hong DY,Chen L,Zhang YY,Xu YN,Pan D,Fu LY,Tao L,Luo H,Shen XC
AF-100-15 was used in Cell Culture to study the long-term exposure of breast epithelial cells to 17β-estradiol (E2) to investigate the chemopreventive potential of baicalein on neoplastic transformation and suggest that baicalein could be a potential drug for reducing the risk of estrogen-dependent breast cancer.
Tue Feb 07 00:00:00 EST 2017
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Nature
Jia Y,Yun CH,Park E,Ercan D,Manuia M,Juarez J,Xu C,Rhee K,Chen T,Zhang H,Palakurthi S,Jang J,Lelais G,DiDonato M,Bursulaya B,Michellys PY,Epple R,Marsilje TH,McNeill M,Lu W,Harris J,Bender S,Wong KK,Jänne PA,Eck MJ
AF-100-15 was used in Cell Culture to investigate use of EAI045 to treat EGFR non-small cell lung cancer.
Thu Jun 02 00:00:00 EDT 2016
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
Cancer cell
Vo BT,Wolf E,Kawauchi D,Gebhardt A,Rehg JE,Finkelstein D,Walz S,Murphy BL,Youn YH,Han YG,Eilers M,Roussel MF
Mon Jan 11 00:00:00 EST 2016
c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma.
The Journal of clinical investigation
Huang M,Liu T,Ma P,Mitteer RA,Zhang Z,Kim HJ,Yeo E,Zhang D,Cai P,Li C,Zhang L,Zhao B,Roccograndi L,O'Rourke DM,Dahmane N,Gong Y,Koumenis C,Fan Y
Mon May 02 00:00:00 EDT 2016
Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.
Hepatology (Baltimore, Md.)
Yi J,Lu L,Yanger K,Wang W,Sohn BH,Stanger BZ,Zhang M,Martin JF,Ajani JA,Chen J,Lee JS,Song S,Johnson RL
AF-100-15 was used in Cell Culture to study the role of Hippo signalling pathway kinases, large tumour suppressor homologues 1 and 2, during mouse liver development.
Tue Nov 01 00:00:00 EDT 2016
Organoid culture systems for prostate epithelial and cancer tissue.
Nature protocols
Drost J,Karthaus WR,Gao D,Driehuis E,Sawyers CL,Chen Y,Clevers H
AF-100-15 was used in Cell Culture to describe a strategy for the generation of 3D prostate organoid cultures from a variety of cell types.
Mon Feb 01 00:00:00 EST 2016
FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma.
The EMBO journal
Suryo Rahmanto A,Savov V,Brunner A,Bolin S,Weishaupt H,Malyukova A,Rosén G,Čančer M,Hutter S,Sundström A,Kawauchi D,Jones DT,Spruck C,Taylor MD,Cho YJ,Pfister SM,Kool M,Korshunov A,Swartling FJ,Sangfelt O
Mon Oct 17 00:00:00 EDT 2016
Dual Therapeutic Action of a Neutralizing Anti-FGF2 Aptamer in Bone Disease and Bone Cancer Pain.
Molecular therapy : the journal of the American Society of Gene Therapy
Jin L,Nonaka Y,Miyakawa S,Fujiwara M,Nakamura Y
Tue Nov 01 00:00:00 EDT 2016
Functional screen identifies kinases driving prostate cancer visceral and bone metastasis.
Proceedings of the National Academy of Sciences of the United States of America
Faltermeier CM,Drake JM,Clark PM,Smith BA,Zong Y,Volpe C,Mathis C,Morrissey C,Castor B,Huang J,Witte ON
Tue Jan 12 00:00:00 EST 2016
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.
Proceedings of the National Academy of Sciences of the United States of America
Sasaki N,Sachs N,Wiebrands K,Ellenbroek SI,Fumagalli A,Lyubimova A,Begthel H,van den Born M,van Es JH,Karthaus WR,Li VS,López-Iglesias C,Peters PJ,van Rheenen J,van Oudenaarden A,Clevers H
Tue Sep 13 00:00:00 EDT 2016
A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Ferreira LM,Meissner TB,Mikkelsen TS,Mallard W,O'Donnell CW,Tilburgs T,Gomes HA,Camahort R,Sherwood RI,Gifford DK,Rinn JL,Cowan CA,Strominger JL
Tue May 10 00:00:00 EDT 2016
SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Ozturk S,Papageorgis P,Wong CK,Lambert AW,Abdolmaleky HM,Thiagalingam A,Cohen HT,Thiagalingam S
Tue Jan 19 00:00:00 EST 2016
Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.
Proceedings of the National Academy of Sciences of the United States of America
Cohen MA,Wert KJ,Goldmann J,Markoulaki S,Buganim Y,Fu D,Jaenisch R
Tue Feb 09 00:00:00 EST 2016
Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America
Yoh KE,Regunath K,Guzman A,Lee SM,Pfister NT,Akanni O,Kaufman LJ,Prives C,Prywes R
Tue Oct 11 00:00:00 EDT 2016
Helicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer.
Cancer letters
Yong X,Tang B,Xiao YF,Xie R,Qin Y,Luo G,Hu CJ,Dong H,Yang SM
AF-100-15 was used in Sample Preparation to investigate Helicobacter pylori infection effects on cancer stem cells.
Sun May 01 00:00:00 EDT 2016
SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans.
Oncogene
Zhang L,Zhang W,Li Y,Alvarez A,Li Z,Wang Y,Song L,Lv D,Nakano I,Hu B,Cheng SY,Feng H
Thu Oct 27 00:00:00 EDT 2016
Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.
Oncogene
Kim DY,Helfman DM
AF-100-15 was used in Cell Culture to suggest that decreased expression of MLCK may have a critical role during tumor progression by facilitating the metastatic potential of tumor cells.
Thu Aug 25 00:00:00 EDT 2016
P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.
The Journal of cell biology
Hashimoto A,Oikawa T,Hashimoto S,Sugino H,Yoshikawa A,Otsuka Y,Handa H,Onodera Y,Nam JM,Oneyama C,Okada M,Fukuda M,Sabe H
Mon Apr 11 00:00:00 EDT 2016
Novel 3-D cell culture system for in vitro evaluation of anticancer drugs under anchorage-independent conditions.
Cancer science
Aihara A,Abe N,Saruhashi K,Kanaki T,Nishino T
Thu Dec 01 00:00:00 EST 2016
Galectin-3 modulates the EGFR signalling-mediated regulation of Sox2 expression via c-Myc in lung cancer.
Glycobiology
Kuo HY,Hsu HT,Chen YC,Chang YW,Liu FT,Wu CW
AF-100-15 was used in Cell Culture to investigate the mechanisms of galectin-3 involved in the regulation of cancer stem-like cells.
Mon Feb 01 00:00:00 EST 2016
Systems Genetics Analysis of a Recombinant Inbred Mouse Cell Culture Panel Reveals Wnt Pathway Member Lrp6 as a Regulator of Adult Hippocampal Precursor Cell Proliferation.
Stem cells (Dayton, Ohio)
Kannan S,Nicola Z,Overall RW,Ichwan M,Ramírez-Rodríguez G,N Grzyb A,Patone G,Saar K,Hübner N,Kempermann G
Tue Mar 01 00:00:00 EST 2016
LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling the Expression of a Novel Target Gene, HEYL.
Stem cells (Dayton, Ohio)
Hirano K,Namihira M
Fri Jul 01 00:00:00 EDT 2016
Modulation of the Innate Immune Response by Human Neural Precursors Prevails over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model of Pelizaeus-Merzbacher Disease.
Stem cells (Dayton, Ohio)
Marteyn A,Sarrazin N,Yan J,Bachelin C,Deboux C,Santin MD,Gressens P,Zujovic V,Baron-Van Evercooren A
Fri Apr 01 00:00:00 EDT 2016
Functional Interference in the Bone Marrow Microenvironment by Disseminated Breast Cancer Cells.
Stem cells (Dayton, Ohio)
Dhawan A,von Bonin M,Bray LJ,Freudenberg U,Pishali Bejestani E,Werner C,Hofbauer LC,Wobus M,Bornhäuser M
Mon Aug 01 00:00:00 EDT 2016
Brain Insulin-Like Growth Factor-I Directs the Transition from Stem Cells to Mature Neurons During Postnatal/Adult Hippocampal Neurogenesis.
Stem cells (Dayton, Ohio)
Nieto-Estévez V,Oueslati-Morales CO,Li L,Pickel J,Morales AV,Vicario-Abejón C
Mon Aug 01 00:00:00 EDT 2016
MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1.
Stem cells (Dayton, Ohio)
Jung KH,McCarthy RL,Zhou C,Uprety N,Barton MC,Beretta L
Sun May 01 00:00:00 EDT 2016
Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase.
Journal of immunology (Baltimore, Md. : 1950)
Müller-Durovic B,Lanna A,Covre LP,Mills RS,Henson SM,Akbar AN
Sat Oct 01 00:00:00 EDT 2016
Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2.
Journal of cellular and molecular medicine
de Jong OG,van Balkom BW,Gremmels H,Verhaar MC
Mon Feb 01 00:00:00 EST 2016
Necdin controls EGFR signaling linked to astrocyte differentiation in primary cortical progenitor cells.
Cellular signalling
Fujimoto I,Hasegawa K,Fujiwara K,Yamada M,Yoshikawa K
Mon Feb 01 00:00:00 EST 2016
Detecting the H3F3A mutant allele found in high-grade pediatric glioma by real-time PCR.
Journal of neuro-oncology
Zhang R,Han J,Daniels D,Huang H,Zhang Z
AF-100-15 was used in Cell Culture to describe a real-time PCR-based procedure involving a mutant-specific primer, a blocker of oligonucleotide, and a reverse primer that can differentiate samples with the H3F3A K27M mutation from those that do not.
Fri Jan 01 00:00:00 EST 2016
Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 T.
NMR in biomedicine
Porcari P,Hegi ME,Lei H,Hamou MF,Vassallo I,Capuani S,Gruetter R,Mlynarik V
AF-100-15 was used in In vitro experiments to study whether diffusion MRI might be a useful technique for early detection and characterization of slow-growing and diffuse infiltrative gliomas, such as the proposed new models, LN-2669GS and LN-2540GS glioma sphere xenografts.
Tue Nov 01 00:00:00 EDT 2016
The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration.
Cell death & disease
Hall AE,Lu WT,Godfrey JD,Antonov AV,Paicu C,Moxon S,Dalmay T,Wilczynska A,Muller PA,Bushell M
Thu Apr 07 00:00:00 EDT 2016
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.
Nature communications
Grampp S,Platt JL,Lauer V,Salama R,Kranz F,Neumann VK,Wach S,Stöhr C,Hartmann A,Eckardt KU,Ratcliffe PJ,Mole DR,Schödel J
Mon Oct 24 00:00:00 EDT 2016
A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion.
Scientific reports
Raimondi C,Calleja V,Ferro R,Fantin A,Riley AM,Potter BV,Brennan CH,Maffucci T,Larijani B,Falasca M
Fri May 20 00:00:00 EDT 2016
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
Nature communications
Hashimoto S,Mikami S,Sugino H,Yoshikawa A,Hashimoto A,Onodera Y,Furukawa S,Handa H,Oikawa T,Okada Y,Oya M,Sabe H
Mon Feb 08 00:00:00 EST 2016
Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling.
Nature communications
Shindo Y,Iwamoto K,Mouri K,Hibino K,Tomita M,Kosako H,Sako Y,Takahashi K
Wed Jan 20 00:00:00 EST 2016
Biological impact of xeno-free chemically defined cryopreservation medium on amniotic epithelial cells.
Stem cell research & therapy
Miki T,Wong W,Zhou E,Gonzalez A,Garcia I,Grubbs BH
AF-100-15 was used in Cell Culture to study xeno-free (XF) cryopreservation media for the cryopreservation of amnion-derived stem cells.
Tue Jan 12 00:00:00 EST 2016
miR-612 suppresses stem cell-like property of hepatocellular carcinoma cells by modulating Sp1/Nanog signaling.
Cell death & disease
Liu Y,Liu DL,Dong LL,Wen D,Shi DM,Zhou J,Fan J,Wu WZ
Thu Sep 29 00:00:00 EDT 2016
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Nature communications
Guo X,Sun X,Hu D,Wang YJ,Fujioka H,Vyas R,Chakrapani S,Joshi AU,Luo Y,Mochly-Rosen D,Qi X
Fri Aug 26 00:00:00 EDT 2016
A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2.
Scientific reports
Breitkopf SB,Yang X,Begley MJ,Kulkarni M,Chiu YH,Turke AB,Lauriol J,Yuan M,Qi J,Engelman JA,Hong P,Kontaridis MI,Cantley LC,Perrimon N,Asara JM
Wed Feb 03 00:00:00 EST 2016
Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma.
Nature communications
Bagó JR,Alfonso-Pecchio A,Okolie O,Dumitru R,Rinkenbaugh A,Baldwin AS,Miller CR,Magness ST,Hingtgen SD
Tue Feb 02 00:00:00 EST 2016
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.
Nature communications
Huang T,Alvarez AA,Pangeni RP,Horbinski CM,Lu S,Kim SH,James CD,J Raizer J,A Kessler J,Brenann CW,Sulman EP,Finocchiaro G,Tan M,Nishikawa R,Lu X,Nakano I,Hu B,Cheng SY
Tue Oct 04 00:00:00 EDT 2016
Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.
Scientific reports
Yamada K,Miyamoto Y,Tsujii A,Moriyama T,Ikuno Y,Shiromizu T,Serada S,Fujimoto M,Tomonaga T,Naka T,Yoneda Y,Oka M
Thu Feb 18 00:00:00 EST 2016
Isolation of highly enriched primary human microglia for functional studies.
Scientific reports
Rustenhoven J,Park TI,Schweder P,Scotter J,Correia J,Smith AM,Gibbons HM,Oldfield RL,Bergin PS,Mee EW,Faull RL,Curtis MA,Scott Graham E,Dragunow M
Mon Jan 18 00:00:00 EST 2016
miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma.
Journal of experimental & clinical cancer research : CR
Zhang X,Jiang P,Shuai L,Chen K,Li Z,Zhang Y,Jiang Y,Li X
AF-100-15 was used in Cell Culture to investigate the role of MicroRNAs in the regulation of CD90+ cancer stem cells.
Fri Nov 11 00:00:00 EST 2016
Aldh1 Expression and Activity Increase During Tumor Evolution in Sarcoma Cancer Stem Cell Populations.
Scientific reports
Martinez-Cruzado L,Tornin J,Santos L,Rodriguez A,García-Castro J,Morís F,Rodriguez R
Mon Jun 13 00:00:00 EDT 2016
Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates.
Scientific reports
Ding X,Liu G,Xu B,Wu C,Hui N,Ni X,Wang J,Du M,Teng X,Wu J
Thu Jun 30 00:00:00 EDT 2016
Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates.
Scientific reports
Ding X,Liu G,Xu B,Wu C,Hui N,Ni X,Wang J,Du M,Teng X,Wu J
Thu Jun 30 00:00:00 EDT 2016
MHC-class-II are expressed in a subpopulation of human neural stem cells in vitro in an IFNγ-independent fashion and during development.
Scientific reports
Vagaska B,New SE,Alvarez-Gonzalez C,D'Acquisto F,Gomez SG,Bulstrode NW,Madrigal A,Ferretti P
Fri Apr 15 00:00:00 EDT 2016
Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities.
Nature communications
Chen S,Bremer AW,Scheideler OJ,Na YS,Todhunter ME,Hsiao S,Bomdica PR,Maharbiz MM,Gartner ZJ,Schaffer DV
Tue Jan 12 00:00:00 EST 2016
Estrogen-induced SDF-1α production promotes the progression of ER-negative breast cancer via the accumulation of MDSCs in the tumor microenvironment.
Scientific reports
Ouyang L,Chang W,Fang B,Qin J,Qu X,Cheng F
Tue Dec 20 00:00:00 EST 2016
Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.
Molecular & cellular proteomics : MCP
Chen Y,Hoover ME,Dang X,Shomo AA,Guan X,Marshall AG,Freitas MA,Young NL
Tue Mar 01 00:00:00 EST 2016
Porcine milk-derived exosomes promote proliferation of intestinal epithelial cells.
Scientific reports
Chen T,Xie MY,Sun JJ,Ye RS,Cheng X,Sun RP,Wei LM,Li M,Lin DL,Jiang QY,Xi QY,Zhang YL
Tue Sep 20 00:00:00 EDT 2016
MiR-630 suppresses breast cancer progression by targeting metadherin.
Oncotarget
Zhou CX,Wang CL,Yu AL,Wang QY,Zhan MN,Tang J,Gong XF,Yin QQ,He M,He JR,Chen GQ,Zhao Q
AF-100-15 was used in Cell Culture to examine miR-630 expression in human breast cancers, and mechanisms of suppressing cancer progression.
Tue Jan 12 00:00:00 EST 2016
miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a.
Scientific reports
Xue Q,Yu C,Wang Y,Liu L,Zhang K,Fang C,Liu F,Bian G,Song B,Yang A,Ju G,Wang J
Wed May 25 00:00:00 EDT 2016
Foetal hepatic progenitor cells assume a cholangiocytic cell phenotype during two-dimensional pre-culture.
Scientific reports
Anzai K,Chikada H,Tsuruya K,Ida K,Kagawa T,Inagaki Y,Mine T,Kamiya A
Thu Jun 23 00:00:00 EDT 2016
The ERK signaling target RNF126 regulates anoikis resistance in cancer cells by changing the mitochondrial metabolic flux.
Cell discovery
Yoshino S,Hara T,Nakaoka HJ,Kanamori A,Murakami Y,Seiki M,Sakamoto T
Wed Jul 27 00:00:00 EDT 2016
Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.
Scientific reports
Abdel-Sayed P,Kaeppeli A,Siriwardena T,Darbre T,Perron K,Jafari P,Reymond JL,Pioletti DP,Applegate LA
Thu Feb 25 00:00:00 EST 2016
Combinatorial microenvironmental regulation of liver progenitor differentiation by Notch ligands, TGFβ, and extracellular matrix.
Scientific reports
Kaylan KB,Ermilova V,Yada RC,Underhill GH
Wed Mar 30 00:00:00 EDT 2016
EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance.
Nature communications
Depner C,Zum Buttel H,Böğürcü N,Cuesta AM,Aburto MR,Seidel S,Finkelmeier F,Foss F,Hofmann J,Kaulich K,Barbus S,Segarra M,Reifenberger G,Garvalov BK,Acker T,Acker-Palmer A
Fri Jul 29 00:00:00 EDT 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 EDT 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 EDT 2016
Immobilized Metal Affinity Chromatography Coupled to Multiple Reaction Monitoring Enables Reproducible Quantification of Phospho-signaling.
Molecular & cellular proteomics : MCP
Kennedy JJ,Yan P,Zhao L,Ivey RG,Voytovich UJ,Moore HD,Lin C,Pogosova-Agadjanyan EL,Stirewalt DL,Reding KW,Whiteaker JR,Paulovich AG
Mon Feb 01 00:00:00 EST 2016
Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis.
Nature communications
Cui Q,Yang S,Ye P,Tian E,Sun G,Zhou J,Sun G,Liu X,Chen C,Murai K,Zhao C,Azizian KT,Yang L,Warden C,Wu X,D'Apuzzo M,Brown C,Badie B,Peng L,Riggs AD,Rossi JJ,Shi Y
Wed Feb 03 00:00:00 EST 2016
Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors.
Scientific reports
Wiltshire R,Nelson V,Kho DT,Angel CE,O'Carroll SJ,Graham ES
Wed Jan 27 00:00:00 EST 2016
The Wnt/β-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells.
Scientific reports
Dong HJ,Jang GB,Lee HY,Park SR,Kim JY,Nam JS,Hong IS
Fri Mar 11 00:00:00 EST 2016
The Wnt/β-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells.
Scientific reports
Dong HJ,Jang GB,Lee HY,Park SR,Kim JY,Nam JS,Hong IS
Fri Mar 11 00:00:00 EST 2016
Functional Recovery from Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training in Mice with Chronic Spinal Cord Injury.
Scientific reports
Tashiro S,Nishimura S,Iwai H,Sugai K,Zhang L,Shinozaki M,Iwanami A,Toyama Y,Liu M,Okano H,Nakamura M
Wed Aug 03 00:00:00 EDT 2016
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.
Nature communications
Lee DH,Park JO,Kim TS,Kim SK,Kim TH,Kim MC,Park GS,Kim JH,Kuninaka S,Olson EN,Saya H,Kim SY,Lee H,Lim DS
Thu Jun 30 00:00:00 EDT 2016
Metabolic flux-driven sialylation alters internalization, recycling, and drug sensitivity of the epidermal growth factor receptor (EGFR) in SW1990 pancreatic cancer cells.
Oncotarget
Mathew MP,Tan E,Saeui CT,Bovonratwet P,Sklar S,Bhattacharya R,Yarema KJ
AF-100-15 was used in Sample Preparation (Western Blotting) to demonstrate how the 1,3,4-O-Bu3ManNAc compound inhibits EGFR activity and provides synergy with tyrosine kinase inhibitors (TKI) drugs.
Tue Oct 11 00:00:00 EDT 2016
β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.
The Journal of biological chemistry
Alekhina O,Marchese A
Fri Dec 09 00:00:00 EST 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
Thu Sep 01 00:00:00 EDT 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
Thu Sep 01 00:00:00 EDT 2016
The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal Trafficking of Caveolin 1.
The Journal of biological chemistry
Burana D,Yoshihara H,Tanno H,Yamamoto A,Saeki Y,Tanaka K,Komada M
Fri Mar 18 00:00:00 EDT 2016
The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal Trafficking of Caveolin 1.
The Journal of biological chemistry
Burana D,Yoshihara H,Tanno H,Yamamoto A,Saeki Y,Tanaka K,Komada M
Fri Mar 18 00:00:00 EDT 2016
The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner.
Oncotarget
Heulot M,Chevalier N,Puyal J,Margue C,Michel S,Kreis S,Kulms D,Barras D,Nahimana A,Widmann C
AF-100-15 was used in Sample Preparation (FC/FACS) to investigate malignancy inhibition by targeting a p120 RasGAP in cancer.
Tue Sep 27 00:00:00 EDT 2016
Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors.
Scientific reports
Huang CC,Lee CC,Lin HH,Chang JY
Fri Jul 08 00:00:00 EDT 2016
Induction of Germ Cell-like Cells from Porcine Induced Pluripotent Stem Cells.
Scientific reports
Wang H,Xiang J,Zhang W,Li J,Wei Q,Zhong L,Ouyang H,Han J
Mon Jun 06 00:00:00 EDT 2016
Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice.
Cell death & disease
Lin Y,Zhang JC,Yao CY,Wu Y,Abdelgawad AF,Yao SL,Yuan SY
Thu Jun 23 00:00:00 EDT 2016
Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.
Scientific reports
Fukuda S,Nishida-Fukuda H,Nanba D,Nakashiro K,Nakayama H,Kubota H,Higashiyama S
Tue Feb 02 00:00:00 EST 2016
Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.
Scientific reports
Fukuda S,Nishida-Fukuda H,Nanba D,Nakashiro K,Nakayama H,Kubota H,Higashiyama S
Tue Feb 02 00:00:00 EST 2016
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells.
Nature communications
Liu CC,Lin SP,Hsu HS,Yang SH,Lin CH,Yang MH,Hung MC,Hung SC
Thu Jun 16 00:00:00 EDT 2016
Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
Nature communications
Hasegawa K,Yasuda T,Shiraishi C,Fujiwara K,Przedborski S,Mochizuki H,Yoshikawa K
Mon Mar 14 00:00:00 EDT 2016
Hierarchy of cellular decisions in collective behavior: Implications for wound healing.
Scientific reports
Wickert LE,Pomerenke S,Mitchell I,Masters KS,Kreeger PK
Tue Feb 02 00:00:00 EST 2016
N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4.
Scientific reports
Hang Q,Isaji T,Hou S,Zhou Y,Fukuda T,Gu J
Mon Sep 19 00:00:00 EDT 2016
Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells.
Scientific reports
Pode-Shakked N,Pleniceanu O,Gershon R,Shukrun R,Kanter I,Bucris E,Pode-Shakked B,Tam G,Tam H,Caspi R,Pri-Chen S,Vax E,Katz G,Omer D,Harari-Steinberg O,Kalisky T,Dekel B
Tue Mar 29 00:00:00 EDT 2016
The Dipole Potential Modifies the Clustering and Ligand Binding Affinity of ErbB Proteins and Their Signaling Efficiency.
Scientific reports
Kovács T,Batta G,Hajdu T,Szabó Á,Váradi T,Zákány F,Csomós I,Szöllősi J,Nagy P
Mon Oct 24 00:00:00 EDT 2016
PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.
Scientific reports
Fujii S,Suzuki K,Kawamoto A,Ishibashi F,Nakata T,Murano T,Ito G,Shimizu H,Mizutani T,Oshima S,Tsuchiya K,Nakamura T,Araki A,Ohtsuka K,Okamoto R,Watanabe M
Wed Nov 09 00:00:00 EST 2016
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Scientific reports
Borgs L,Peyre E,Alix P,Hanon K,Grobarczyk B,Godin JD,Purnelle A,Krusy N,Maquet P,Lefebvre P,Seutin V,Malgrange B,Nguyen L
Mon Sep 19 00:00:00 EDT 2016
Cellular microenvironment modulates the galvanotaxis of brain tumor initiating cells.
Scientific reports
Huang YJ,Hoffmann G,Wheeler B,Schiapparelli P,Quinones-Hinojosa A,Searson P
Mon Feb 22 00:00:00 EST 2016
Sequential cancer mutations in cultured human intestinal stem cells.
Nature
Drost J,van Jaarsveld RH,Ponsioen B,Zimberlin C,van Boxtel R,Buijs A,Sachs N,Overmeer RM,Offerhaus GJ,Begthel H,Korving J,van de Wetering M,Schwank G,Logtenberg M,Cuppen E,Snippert HJ,Medema JP,Kops GJ,Clevers H
Thu May 07 00:00:00 EDT 2015
Long-term culture of genome-stable bipotent stem cells from adult human liver.
Cell
Huch M,Gehart H,van Boxtel R,Hamer K,Blokzijl F,Verstegen MM,Ellis E,van Wenum M,Fuchs SA,de Ligt J,van de Wetering M,Sasaki N,Boers SJ,Kemperman H,de Jonge J,Ijzermans JN,Nieuwenhuis EE,Hoekstra R,Strom S,Vries RR,van der Laan LJ,Cuppen E,Clevers H
Thu Jan 15 00:00:00 EST 2015
TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.
The Journal of clinical investigation
Hu Z,Ding W,Zhu D,Yu L,Jiang X,Wang X,Zhang C,Wang L,Ji T,Liu D,He D,Xia X,Zhu T,Wei J,Wu P,Wang C,Xi L,Gao Q,Chen G,Liu R,Li K,Li S,Wang S,Zhou J,Ma D,Wang H
Thu Jan 01 00:00:00 EST 2015
V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation.
Autophagy
Florey O,Gammoh N,Kim SE,Jiang X,Overholtzer M
AF-100-15 was used in Cell Culture to demonstrate that the noncanonical activity of autophagy proteins which targets lipidation of microtubule-associated protein 1 light chain 3 (LC3) requires activity of the vacuolar-type H(+)-ATPase (V-ATPase) and is induced by osmotic imbalances within endolysosomal compartments.
Mon Nov 16 00:00:00 EST 2015
Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes.
Proceedings of the National Academy of Sciences of the United States of America
Tilburgs T,Crespo ÂC,van der Zwan A,Rybalov B,Raj T,Stranger B,Gardner L,Moffett A,Strominger JL
Tue Jun 09 00:00:00 EDT 2015
Empirical inference of circuitry and plasticity in a kinase signaling network.
Proceedings of the National Academy of Sciences of the United States of America
Wilkes EH,Terfve C,Gribben JG,Saez-Rodriguez J,Cutillas PR
Tue Jun 23 00:00:00 EDT 2015
The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Tilburgs T,Evans JH,Crespo ÂC,Strominger JL
Tue Oct 27 00:00:00 EDT 2015
Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Wang F,Tidei JJ,Polich ED,Gao Y,Zhao H,Perrone-Bizzozero NI,Guo W,Zhao X
Tue Sep 08 00:00:00 EDT 2015
Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance.
Advanced healthcare materials
Villarin BL,Cameron K,Szkolnicka D,Rashidi H,Bates N,Kimber SJ,Flint O,Forbes SJ,Iredale JP,Bradley M,Hay DC
Wed Aug 26 00:00:00 EDT 2015
miR-30e* is an independent subtype-specific prognostic marker in breast cancer.
British journal of cancer
D'Aiuto F,Callari M,Dugo M,Merlino G,Musella V,Miodini P,Paolini B,Cappelletti V,Daidone MG
Tue Jul 14 00:00:00 EDT 2015
Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression.
Oncogene
Goka ET,Lippman ME
Fri Oct 16 00:00:00 EDT 2015
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
The Journal of cell biology
Tornavaca O,Chia M,Dufton N,Almagro LO,Conway DE,Randi AM,Schwartz MA,Matter K,Balda MS
Mon Mar 16 00:00:00 EDT 2015
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.
The Journal of cell biology
Kim NG,Gumbiner BM
Mon Aug 03 00:00:00 EDT 2015
Notch1 stimulation induces a vascularization switch with pericyte-like cell differentiation of glioblastoma stem cells.
Stem cells (Dayton, Ohio)
Guichet PO,Guelfi S,Teigell M,Hoppe L,Bakalara N,Bauchet L,Duffau H,Lamszus K,Rothhut B,Hugnot JP
Thu Jan 01 00:00:00 EST 2015
Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/Bim pathway.
Stem cells (Dayton, Ohio)
Gargini R,Cerliani JP,Escoll M,Antón IM,Wandosell F
Sun Mar 01 00:00:00 EST 2015
Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells.
Stem cells (Dayton, Ohio)
Nakagomi T,Kubo S,Nakano-Doi A,Sakuma R,Lu S,Narita A,Kawahara M,Taguchi A,Matsuyama T
Mon Jun 01 00:00:00 EDT 2015
Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts.
Stem cells (Dayton, Ohio)
Kitajima S,Kohno S,Kondoh A,Sasaki N,Nishimoto Y,Li F,Abdallah Mohammed MS,Muranaka H,Nagatani N,Suzuki M,Kido Y,Takahashi C
Fri May 01 00:00:00 EDT 2015
NTPDase2 and purinergic signaling control progenitor cell proliferation in neurogenic niches of the adult mouse brain.
Stem cells (Dayton, Ohio)
Gampe K,Stefani J,Hammer K,Brendel P,Pötzsch A,Enikolopov G,Enjyoji K,Acker-Palmer A,Robson SC,Zimmermann H
Thu Jan 01 00:00:00 EST 2015
Feedforward regulation of mRNA stability by prolonged extracellular signal-regulated kinase activity.
The FEBS journal
Nagashima T,Inoue N,Yumoto N,Saeki Y,Magi S,Volinsky N,Sorkin A,Kholodenko BN,Okada-Hatakeyama M
Sun Feb 01 00:00:00 EST 2015
Targeting lung cancer stem-like cells with TRAIL gene armed oncolytic adenovirus.
Journal of cellular and molecular medicine
Yang Y,Xu H,Huang W,Ding M,Xiao J,Yang D,Li H,Liu XY,Chu L
Fri May 01 00:00:00 EDT 2015
Time-domain microfluidic fluorescence lifetime flow cytometry for high-throughput Förster resonance energy transfer screening.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Nedbal J,Visitkul V,Ortiz-Zapater E,Weitsman G,Chana P,Matthews DR,Ng T,Ameer-Beg SM
Sun Feb 01 00:00:00 EST 2015
Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation.
BioMed research international
Vallejo-Flores G,Torres J,Sandoval-Montes C,Arévalo-Romero H,Meza I,Camorlinga-Ponce M,Torres-Morales J,Chávez-Rueda AK,Legorreta-Haquet MV,Fuentes-Pananá EM
AF-100-15 was used in Cell Culture to study how CagA alters cellular processes associated with carcinogenic events by investigating the capacity of H. pylori CagA positive and negative strains to alter nontransformed MCF-10A glandular acini formation.
Mon Aug 29 00:00:00 EDT 2016
Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture.
Nature communications
Fridriksdottir AJ,Kim J,Villadsen R,Klitgaard MC,Hopkinson BM,Petersen OW,Rønnov-Jessen L
Fri Nov 13 00:00:00 EST 2015
The Lin28/let-7 axis is critical for myelination in the peripheral nervous system.
Nature communications
Gökbuget D,Pereira JA,Bachofner S,Marchais A,Ciaudo C,Stoffel M,Schulte JH,Suter U
Wed Oct 14 00:00:00 EDT 2015
Identification of thiostrepton as a novel therapeutic agent that targets human colon cancer stem cells.
Cell death & disease
Ju SY,Huang CY,Huang WC,Su Y
Thu Jul 02 00:00:00 EDT 2015
Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells.
Scientific reports
Mahankali M,Farkaly T,Bedi S,Hostetler HA,Gomez-Cambronero J
Fri Oct 23 00:00:00 EDT 2015
Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method.
Nature communications
Lin JR,Fallahi-Sichani M,Sorger PK
Thu Sep 24 00:00:00 EDT 2015
RGD-modifided oncolytic adenovirus exhibited potent cytotoxic effect on CAR-negative bladder cancer-initiating cells.
Cell death & disease
Yang Y,Xu H,Shen J,Yang Y,Wu S,Xiao J,Xu Y,Liu XY,Chu L
Thu May 14 00:00:00 EDT 2015
Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
Scientific reports
Palm T,Bolognin S,Meiser J,Nickels S,Träger C,Meilenbrock RL,Brockhaus J,Schreitmüller M,Missler M,Schwamborn JC
Fri Nov 06 00:00:00 EST 2015
Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts.
Scientific reports
Kim J,Kim KP,Lim KT,Lee SC,Yoon J,Song G,Hwang SI,Schöler HR,Cantz T,Han DW
Tue Oct 27 00:00:00 EDT 2015
Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.
Nature communications
Capuani F,Conte A,Argenzio E,Marchetti L,Priami C,Polo S,Di Fiore PP,Sigismund S,Ciliberto A
Wed Aug 12 00:00:00 EDT 2015
Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.
Scientific reports
Okuyama-Dobashi K,Kasai H,Tanaka T,Yamashita A,Yasumoto J,Chen W,Okamoto T,Maekawa S,Watashi K,Wakita T,Ryo A,Suzuki T,Matsuura Y,Enomoto N,Moriishi K
Mon Nov 23 00:00:00 EST 2015
Dysfunction of platelet-derived growth factor receptor α (PDGFRα) represses the production of oligodendrocytes from arylsulfatase A-deficient multipotential neural precursor cells.
The Journal of biological chemistry
Pituch KC,Moyano AL,Lopez-Rosas A,Marottoli FM,Li G,Hu C,van Breemen R,Månsson JE,Givogri MI
Fri Mar 13 00:00:00 EDT 2015
Simultaneous MR imaging for tissue engineering in a rat model of stroke.
Scientific reports
Nicholls FJ,Ling W,Ferrauto G,Aime S,Modo M
Wed Sep 30 00:00:00 EDT 2015
Optimizing culture medium composition to improve oligodendrocyte progenitor cell yields in vitro from subventricular zone-derived neural progenitor cell neurospheres.
PloS one
Franco PG,Pasquini JM,Silvestroff L
AF-100-15 was used in Cell Culture to study cell proliferation and OPC yield using Subventricular Zone-derived NSC/NPC primary cultures from newborn mice and studying the effects of different growth factor combinations on the. The Platelet Derived Growth Factor-AA and BB homodimers had a positive and significant impact on OPC generation. The OPC generated by this protocol were able to mature into Myelin Basic Protein-expressing cells thus proposing an optimized in vitro method for increasing OPC
Thu Mar 31 00:00:00 EDT 2016
Giant Panda (Ailuropoda melanoleuca) Buccal Mucosa Tissue as a Source of Multipotent Progenitor Cells.
PloS one
Prescott HM,Manning C,Gardner A,Ritchie WA,Pizzi R,Girling S,Valentine I,Wang C,Jahoda CA
AF-100-15 was used in Cell Culture to demonstrate that giant panda cheek skin can be a useful source of m-SKP multipotent progenitors.
Tue May 31 00:00:00 EDT 2016
Giant Panda (Ailuropoda melanoleuca) Buccal Mucosa Tissue as a Source of Multipotent Progenitor Cells.
PloS one
Prescott HM,Manning C,Gardner A,Ritchie WA,Pizzi R,Girling S,Valentine I,Wang C,Jahoda CA
AF-100-15 was used in Cell Culture to demonstrate that giant panda cheek skin can be a useful source of m-SKP multipotent progenitors.
Tue May 31 00:00:00 EDT 2016
PSA-NCAM-negative neural crest cells emerging during neural induction of pluripotent stem cells cause mesodermal tumors and unwanted grafts.
Stem cell reports
Lee DR,Yoo JE,Lee JS,Park S,Lee J,Park CY,Ji E,Kim HS,Hwang DY,Kim DS,Kim DW
Tue May 12 00:00:00 EDT 2015
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
Nature communications
Matsuda T,Murao N,Katano Y,Juliandi B,Kohyama J,Akira S,Kawai T,Nakashima K
Mon Mar 09 00:00:00 EDT 2015
Promoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells.
Scientific reports
Mina M,Magi S,Jurman G,Itoh M,Kawaji H,Lassmann T,Arner E,Forrest ARR,Carninci P,Hayashizaki Y,Daub CO,Okada-Hatakeyama M,Furlanello C
Thu Jul 16 00:00:00 EDT 2015
Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine.
Molecular cancer
Yang MC,Wang HC,Hou YC,Tung HL,Chiu TJ,Shan YS
AF-100-15 was used in Cell Culture to investigate the role of autophagy in regulating cancer stemness and chemoresistance of pancreatic cancer.
Mon Oct 12 00:00:00 EDT 2015
PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.
Scientific reports
Hou X,Liu Y,Liu H,Chen X,Liu M,Che H,Guo F,Wang C,Zhang D,Wu J,Chen X,Shen C,Li C,Peng F,Bi Y,Yang Z,Yang G,Ai J,Gao X,Zhao S
Thu Mar 12 00:00:00 EDT 2015
PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.
Scientific reports
Hou X,Liu Y,Liu H,Chen X,Liu M,Che H,Guo F,Wang C,Zhang D,Wu J,Chen X,Shen C,Li C,Peng F,Bi Y,Yang Z,Yang G,Ai J,Gao X,Zhao S
Thu Mar 12 00:00:00 EDT 2015
Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses.
The Journal of biological chemistry
Sparta B,Pargett M,Minguet M,Distor K,Bell G,Albeck JG
Fri Oct 09 00:00:00 EDT 2015
Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.
The Journal of biological chemistry
Bart G,Vico NO,Hassinen A,Pujol FM,Deen AJ,Ruusala A,Tammi RH,Squire A,Heldin P,Kellokumpu S,Tammi MI
Fri May 01 00:00:00 EDT 2015
Loss of anchorage primarily induces non-apoptotic cell death in a human mammary epithelial cell line under atypical focal adhesion kinase signaling.
Cell death & disease
Ishikawa F,Ushida K,Mori K,Shibanuma M
Thu Jan 22 00:00:00 EST 2015
The Axolotl Fibula as a Model for the Induction of Regeneration across Large Segment Defects in Long Bones of the Extremities.
PloS one
Chen X,Song F,Jhamb D,Li J,Bottino MC,Palakal MJ,Stocum DL
Mon Apr 25 00:00:00 EDT 2016
Hypothermic temperature effects on organ survival and restoration.
Scientific reports
Ishikawa J,Oshima M,Iwasaki F,Suzuki R,Park J,Nakao K,Matsuzawa-Adachi Y,Mizutsuki T,Kobayashi A,Abe Y,Kobayashi E,Tezuka K,Tsuji T
Wed Apr 22 00:00:00 EDT 2015
p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activation in renal cell carcinoma.
Cell death & disease
Zhu Y,Liu H,Xu L,An H,Liu W,Liu Y,Lin Z,Xu J
Thu Feb 12 00:00:00 EST 2015
A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness.
Nature communications
Kim T,Yang SJ,Hwang D,Song J,Kim M,Kyum Kim S,Kang K,Ahn J,Lee D,Kim MY,Kim S,Seung Koo J,Seok Koh S,Kim SY,Lim DS
Wed Dec 16 00:00:00 EST 2015
APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation.
Cell death & disease
Shu R,Wong W,Ma QH,Yang ZZ,Zhu H,Liu FJ,Wang P,Ma J,Yan S,Polo JM,Bernard CC,Stanton LW,Dawe GS,Xiao ZC
Thu Feb 19 00:00:00 EST 2015
Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer.
Oncotarget
Chang J,Wang S,Zhang Z,Liu X,Wu Z,Geng R,Ge X,Dai C,Liu R,Zhang Q,Li W,Li J
Tue Feb 10 00:00:00 EST 2015
Mechanism of Resistance and Novel Targets Mediating Resistance to EGFR and c-Met Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
PloS one
Botting GM,Rastogi I,Chhabra G,Nlend M,Puri N
AF-100-15 was used in Sample Preparation (Western Blotting) post IP to study the similarities and differences in mechanisms of EGFR/c-Met tyrosine kinase inhibitors resistance.
Tue May 17 00:00:00 EDT 2016
Antibody-Coupled Magnetic Beads Can Be Reused in Immuno-MRM Assays To Reduce Cost and Extend Antibody Supply.
Journal of proteome research
Zhao L,Whiteaker JR,Voytovich UJ,Ivey RG,Paulovich AG
AF-100-15 was used in Cell Culture to describe a workflow to regenerate anti-peptide polyclonal antibodies coupled to magnetic beads for enrichments in multiplex immuno-MRM assays.
Fri Oct 02 00:00:00 EDT 2015
Isolation and Expansion of Mesenchymal Stem Cells from Human Conjunctival Tissue.
Current protocols in stem cell biology
Nadri S,Yazdani S
AF-100-15 was used in Cell Culture to describe a simple protocol for the isolation and culture of mesenchymal stem cells (MSCs) from conjunctiva stromal tissue, with applications to stem cell biology and regenerative medicine.
Fri May 01 00:00:00 EDT 2015
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Scientific reports
Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP
Mon Nov 09 00:00:00 EST 2015
Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.
Cell death & disease
Montagne R,Berbon M,Doublet L,Debreuck N,Baranzelli A,Drobecq H,Leroy C,Delhem N,Porte H,Copin MC,Dansin E,Furlan A,Tulasne D
Thu May 21 00:00:00 EDT 2015
Revealing the cellular localization of STAT1 during the cell cycle by super-resolution imaging.
Scientific reports
Gao J,Wang F,Liu Y,Cai M,Xu H,Jiang J,Wang H
Thu Mar 12 00:00:00 EDT 2015
Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation.
Cell death & disease
Grassi G,Di Caprio G,Santangelo L,Fimia GM,Cozzolino AM,Komatsu M,Ippolito G,Tripodi M,Alonzi T
Thu Sep 10 00:00:00 EDT 2015
PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium.
Nature communications
Noseda M,Harada M,McSweeney S,Leja T,Belian E,Stuckey DJ,Abreu Paiva MS,Habib J,Macaulay I,de Smith AJ,al-Beidh F,Sampson R,Lumbers RT,Rao P,Harding SE,Blakemore AI,Jacobsen SE,Barahona M,Schneider MD
Mon May 18 00:00:00 EDT 2015
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.
Scientific reports
Miller MA,Moss ML,Powell G,Petrovich R,Edwards L,Meyer AS,Griffith LG,Lauffenburger DA
Mon Oct 19 00:00:00 EDT 2015
The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.
The Journal of biological chemistry
Verma R,Marchese A
Fri Mar 13 00:00:00 EDT 2015
MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death.
The Journal of biological chemistry
Chaudhuri AD,Kabaria S,Choi DC,Mouradian MM,Junn E
Fri May 08 00:00:00 EDT 2015
Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation.
Cell death & disease
Forschbach V,Goppelt-Struebe M,Kunzelmann K,Schreiber R,Piedagnel R,Kraus A,Eckardt KU,Buchholz B
Thu Oct 08 00:00:00 EDT 2015
miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance.
Cell death & disease
De Cola A,Volpe S,Budani MC,Ferracin M,Lattanzio R,Turdo A,D'Agostino D,Capone E,Stassi G,Todaro M,Di Ilio C,Sala G,Piantelli M,Negrini M,Veronese A,De Laurenzi V
Thu Jul 16 00:00:00 EDT 2015
CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells.
Stem cell reports
Kido T,Koui Y,Suzuki K,Kobayashi A,Miura Y,Chern EY,Tanaka M,Miyajima A
Tue Oct 13 00:00:00 EDT 2015
Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.
Scientific reports
Thakur R,Trivedi R,Rastogi N,Singh M,Mishra DP
Thu May 14 00:00:00 EDT 2015
Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation.
The Journal of biological chemistry
Hang Q,Isaji T,Hou S,Im S,Fukuda T,Gu J
Fri Dec 04 00:00:00 EST 2015
Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
Cell
Karthaus WR,Iaquinta PJ,Drost J,Gracanin A,van Boxtel R,Wongvipat J,Dowling CM,Gao D,Begthel H,Sachs N,Vries RGJ,Cuppen E,Chen Y,Sawyers CL,Clevers HC
Thu Sep 25 00:00:00 EDT 2014
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.
Cell
Azzolin L,Panciera T,Soligo S,Enzo E,Bicciato S,Dupont S,Bresolin S,Frasson C,Basso G,Guzzardo V,Fassina A,Cordenonsi M,Piccolo S
Thu Jul 03 00:00:00 EDT 2014
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.
Cell
Azzolin L,Panciera T,Soligo S,Enzo E,Bicciato S,Dupont S,Bresolin S,Frasson C,Basso G,Guzzardo V,Fassina A,Cordenonsi M,Piccolo S
Thu Jul 03 00:00:00 EDT 2014
RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.
Cell
Kitambi SS,Toledo EM,Usoskin D,Wee S,Harisankar A,Svensson R,Sigmundsson K,Kalderén C,Niklasson M,Kundu S,Aranda S,Westermark B,Uhrbom L,Andäng M,Damberg P,Nelander S,Arenas E,Artursson P,Walfridsson J,Forsberg Nilsson K,Hammarström LGJ,Ernfors P
Thu Apr 10 00:00:00 EDT 2014
Induction of entosis by epithelial cadherin expression.
Cell research
Sun Q,Cibas ES,Huang H,Hodgson L,Overholtzer M
Sat Nov 01 00:00:00 EDT 2014
Competition between human cells by entosis.
Cell research
Sun Q,Luo T,Ren Y,Florey O,Shirasawa S,Sasazuki T,Robinson DN,Overholtzer M
Sat Nov 01 00:00:00 EDT 2014
Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.
Cell research
Jiang MH,Cai B,Tuo Y,Wang J,Zang ZJ,Tu X,Gao Y,Su Z,Li W,Li G,Zhang M,Jiao J,Wan Z,Deng C,Lahn BT,Xiang AP
Mon Dec 01 00:00:00 EST 2014
αβT cell receptors expressed by CD4(-)CD8αβ(-) intraepithelial T cells drive their fate into a unique lineage with unusual MHC reactivities.
Immunity
Mayans S,Stepniak D,Palida S,Larange A,Dreux J,Arlian B,Shinnakasu R,Kronenberg M,Cheroutre H,Lambolez F
Thu Aug 21 00:00:00 EDT 2014
Leukemia propagating cells rebuild an evolving niche in response to therapy.
Cancer cell
Duan CW,Shi J,Chen J,Wang B,Yu YH,Qin X,Zhou XC,Cai YJ,Li ZQ,Zhang F,Yin MZ,Tao Y,Mi JQ,Li LH,Enver T,Chen GQ,Hong DL
Mon Jun 16 00:00:00 EDT 2014
Sphere-forming-like cells (squamospheres) with cancer stem-like cell traits from VX2 rabbit buccal squamous cell carcinoma.
International journal of oral science
Chen YK,Huang AH,Lin LM
Mon Dec 01 00:00:00 EST 2014
EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.
The Journal of clinical investigation
Feng H,Lopez GY,Kim CK,Alvarez A,Duncan CG,Nishikawa R,Nagane M,Su AJ,Auron PE,Hedberg ML,Wang L,Raizer JJ,Kessler JA,Parsa AT,Gao WQ,Kim SH,Minata M,Nakano I,Grandis JR,McLendon RE,Bigner DD,Lin HK,Furnari FB,Cavenee WK,Hu B,Yan H,Cheng SY
Mon Sep 01 00:00:00 EDT 2014
Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation.
Autophagy
Liu B,Fang M,Hu Y,Huang B,Li N,Chang C,Huang R,Xu X,Yang Z,Chen Z,Liu W
AF-100-15 was used in In vitro experiments to investigate autophagy defects in cancer.
Sat Mar 01 00:00:00 EST 2014
Mechanotransduction of fluid stresses governs 3D cell migration.
Proceedings of the National Academy of Sciences of the United States of America
Polacheck WJ,German AE,Mammoto A,Ingber DE,Kamm RD
Tue Feb 18 00:00:00 EST 2014
Transcription factor induction of human oligodendrocyte progenitor fate and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Wang J,Pol SU,Haberman AK,Wang C,O'Bara MA,Sim FJ
Tue Jul 15 00:00:00 EDT 2014
Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells.
Experimental & molecular medicine
Lee YK,Hur W,Lee SW,Hong SW,Kim SW,Choi JE,Yoon SK
Fri Feb 21 00:00:00 EST 2014
Suprabasin as a novel tumor endothelial cell marker.
Cancer science
Alam MT,Nagao-Kitamoto H,Ohga N,Akiyama K,Maishi N,Kawamoto T,Shinohara N,Taketomi A,Shindoh M,Hida Y,Hida K
Mon Dec 01 00:00:00 EST 2014
A novel oncogenic role of inositol phosphatase SHIP2 in ER-negative breast cancer stem cells: involvement of JNK/vimentin activation.
Stem cells (Dayton, Ohio)
Fu CH,Lin RJ,Yu J,Chang WW,Liao GS,Chang WY,Tseng LM,Tsai YF,Yu JC,Yu AL
Fri Aug 01 00:00:00 EDT 2014
Peritoneal milky spots serve as a hypoxic niche and favor gastric cancer stem/progenitor cell peritoneal dissemination through hypoxia-inducible factor 1α.
Stem cells (Dayton, Ohio)
Miao ZF,Wang ZN,Zhao TT,Xu YY,Gao J,Miao F,Xu HM
Mon Dec 01 00:00:00 EST 2014
Neutralization of nerve growth factor impairs proliferation and differentiation of adult neural progenitors in the subventricular zone.
Stem cells (Dayton, Ohio)
Scardigli R,Capelli P,Vignone D,Brandi R,Ceci M,La Regina F,Piras E,Cintoli S,Berardi N,Capsoni S,Cattaneo A
Mon Sep 01 00:00:00 EDT 2014
Generation of neuronal progenitor cells in response to tumors in the human brain.
Stem cells (Dayton, Ohio)
Macas J,Ku MC,Nern C,Xu Y,Bühler H,Remke M,Synowitz M,Franz K,Seifert V,Plate KH,Kettenmann H,Glass R,Momma S
Wed Jan 01 00:00:00 EST 2014
Targeting the bHLH transcriptional networks by mutated E proteins in experimental glioma.
Stem cells (Dayton, Ohio)
Beyeler S,Joly S,Fries M,Obermair FJ,Burn F,Mehmood R,Tabatabai G,Raineteau O
Wed Oct 01 00:00:00 EDT 2014
NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival.
Journal of immunology (Baltimore, Md. : 1950)
Gras Navarro A,Kmiecik J,Leiss L,Zelkowski M,Engelsen A,Bruserud Ø,Zimmer J,Enger PØ,Chekenya M
Mon Dec 15 00:00:00 EST 2014
Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.
Journal of immunology (Baltimore, Md. : 1950)
Volonté A,Di Tomaso T,Spinelli M,Todaro M,Sanvito F,Albarello L,Bissolati M,Ghirardelli L,Orsenigo E,Ferrone S,Doglioni C,Stassi G,Dellabona P,Staudacher C,Parmiani G,Maccalli C
Wed Jan 01 00:00:00 EST 2014
Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming.
Neurosurgery
Potts MB,Siu JJ,Price JD,Salinas RD,Cho MJ,Ramos AD,Hahn J,Margeta M,Oldham MC,Lim DA
AF-100-15 was used in Cell Culture to investigate presence of healthy neuronal progenitors in mixed lineage leukaemia-1.
Wed Oct 01 00:00:00 EDT 2014
Cancer stem cells and cisplatin-resistant cells isolated from non-small-lung cancer cell lines constitute related cell populations.
Cancer medicine
Lopez-Ayllon BD,Moncho-Amor V,Abarrategi A,Ibañez de Cáceres I,Castro-Carpeño J,Belda-Iniesta C,Perona R,Sastre L
Wed Oct 01 00:00:00 EDT 2014
An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation.
The Journal of biological chemistry
Isaji T,Im S,Gu W,Wang Y,Hang Q,Lu J,Fukuda T,Hashii N,Takakura D,Kawasaki N,Miyoshi H,Gu J
Fri Jul 25 00:00:00 EDT 2014
Contribution of TIP30 to chemoresistance in laryngeal carcinoma.
Cell death & disease
Zhu M,Yin F,Yang L,Chen S,Chen R,Zhou X,Jing W,Fan X,Jia R,Wang H,Zheng H,Zhao J,Guo Y
Thu Oct 16 00:00:00 EDT 2014
Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.
The Journal of biological chemistry
Zhang A,He X,Zhang L,Yang L,Woodman P,Li W
Fri Oct 17 00:00:00 EDT 2014
PHD3 regulates EGFR internalization and signalling in tumours.
Nature communications
Garvalov BK,Foss F,Henze AT,Bethani I,Gräf-Höchst S,Singh D,Filatova A,Dopeso H,Seidel S,Damm M,Acker-Palmer A,Acker T
Tue Nov 25 00:00:00 EST 2014
Human retinal progenitor cell transplantation preserves vision.
The Journal of biological chemistry
Luo J,Baranov P,Patel S,Ouyang H,Quach J,Wu F,Qiu A,Luo H,Hicks C,Zeng J,Zhu J,Lu J,Sfeir N,Wen C,Zhang M,Reade V,Patel S,Sinden J,Sun X,Shaw P,Young M,Zhang K
Fri Mar 07 00:00:00 EST 2014
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Nature communications
Henze AT,Garvalov BK,Seidel S,Cuesta AM,Ritter M,Filatova A,Foss F,Dopeso H,Essmann CL,Maxwell PH,Reifenberger G,Carmeliet P,Acker-Palmer A,Acker T
Tue Nov 25 00:00:00 EST 2014
Engagement of the small GTPase Rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome.
The Journal of biological chemistry
Chua CE,Tang BL
Fri May 02 00:00:00 EDT 2014
Threonine 680 phosphorylation of FLJ00018/PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by epidermal growth factor receptor signaling regulates cell morphology of Neuro-2a cells.
The Journal of biological chemistry
Sato K,Sugiyama T,Nagase T,Kitade Y,Ueda H
Fri Apr 04 00:00:00 EDT 2014
Threonine 680 phosphorylation of FLJ00018/PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by epidermal growth factor receptor signaling regulates cell morphology of Neuro-2a cells.
The Journal of biological chemistry
Sato K,Sugiyama T,Nagase T,Kitade Y,Ueda H
Fri Apr 04 00:00:00 EDT 2014
Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells.
The Journal of biological chemistry
Bruntz RC,Taylor HE,Lindsley CW,Brown HA
Fri Jan 10 00:00:00 EST 2014
F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).
The Journal of biological chemistry
Liu J,Han L,Li B,Yang J,Huen MS,Pan X,Tsao SW,Cheung AL
Fri Aug 01 00:00:00 EDT 2014
A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype.
Cell death & disease
Gangoso E,Thirant C,Chneiweiss H,Medina JM,Tabernero A
Thu Jan 23 00:00:00 EST 2014
Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer.
Cell death & disease
Feng Y,Zhu M,Dangelmajer S,Lee YM,Wijesekera O,Castellanos CX,Denduluri A,Chaichana KL,Li Q,Zhang H,Levchenko A,Guerrero-Cazares H,Quiñones-Hinojosa A
Thu Dec 11 00:00:00 EST 2014
Cytohesins/ARNO: the function in colorectal cancer cells.
PloS one
Pan T,Sun J,Hu J,Hu Y,Zhou J,Chen Z,Xu D,Xu W,Zheng S,Zhang S
AF-100-15 was used in In vitro experiments to investigate the role of EGF and IGF-I in colorectal cancer tissue compared to adjacent benign tissue.
Fri May 29 00:00:00 EDT 2015
High-throughput de novo screening of receptor agonists with an automated single-cell analysis and isolation system.
Scientific reports
Yoshimoto N,Tatematsu K,Iijima M,Niimi T,Maturana AD,Fujii I,Kondo A,Tanizawa K,Kuroda S
Fri Feb 28 00:00:00 EST 2014
Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance.
Cell death & disease
Dahan P,Martinez Gala J,Delmas C,Monferran S,Malric L,Zentkowski D,Lubrano V,Toulas C,Cohen-Jonathan Moyal E,Lemarie A
Thu Nov 27 00:00:00 EST 2014
DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes.
The Journal of biological chemistry
Sakaguchi M,Murata H,Aoyama Y,Hibino T,Putranto EW,Ruma IM,Inoue Y,Sakaguchi Y,Yamamoto K,Kinoshita R,Futami J,Kataoka K,Iwatsuki K,Huh NH
Fri Aug 22 00:00:00 EDT 2014
Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes.
The Journal of biological chemistry
Zou MR,Cao J,Liu Z,Huh SJ,Polyak K,Yan Q
Fri Jun 20 00:00:00 EDT 2014
The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7.
The Journal of biological chemistry
Chaulk SG,Lattanzi VJ,Hiemer SE,Fahlman RP,Varelas X
Fri Jan 24 00:00:00 EST 2014
Integrin inhibition promotes atypical anoikis in glioma cells.
Cell death & disease
Silginer M,Weller M,Ziegler U,Roth P
Thu Jan 23 00:00:00 EST 2014
Integrin inhibition promotes atypical anoikis in glioma cells.
Cell death & disease
Silginer M,Weller M,Ziegler U,Roth P
Thu Jan 23 00:00:00 EST 2014
The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases.
Scientific reports
Chen L,Fan J,Chen H,Meng Z,Chen Z,Wang P,Liu L
Fri Aug 01 00:00:00 EDT 2014
Testing an unusual in vivo vessel network model: a method to study angiogenesis in the colonial tunicate Botryllus schlosseri.
Scientific reports
Gasparini F,Caicci F,Rigon F,Zaniolo G,Manni L
Wed Sep 24 00:00:00 EDT 2014
The aPKCι blocking agent ATM negatively regulates EMT and invasion of hepatocellular carcinoma.
Cell death & disease
Ma CQ,Yang Y,Wang JM,Du GS,Shen Q,Liu Y,Zhang J,Hu JL,Zhu P,Qi WP,Qian YW,Fu Y
Thu Mar 20 00:00:00 EDT 2014
The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells.
The Journal of biological chemistry
Hiemer SE,Szymaniak AD,Varelas X
Fri May 09 00:00:00 EDT 2014
Differences among brain tumor stem cell types and fetal neural stem cells in focal regions of histone modifications and DNA methylation, broad regions of modifications, and bivalent promoters.
BMC genomics
Yoo S,Bieda MC
AF-100-15 was used in Cell Culture to target epigenetic effects in cancer.
Wed Aug 27 00:00:00 EDT 2014
Conformational coupling across the plasma membrane in activation of the EGF receptor.
Cell
Endres NF,Das R,Smith AW,Arkhipov A,Kovacs E,Huang Y,Pelton JG,Shan Y,Shaw DE,Wemmer DE,Groves JT,Kuriyan J
Thu Jan 31 00:00:00 EST 2013
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
Cancer cell
Cooks T,Pateras IS,Tarcic O,Solomon H,Schetter AJ,Wilder S,Lozano G,Pikarsky E,Forshew T,Rosenfeld N,Harpaz N,Itzkowitz S,Harris CC,Rotter V,Gorgoulis VG,Oren M
Mon May 13 00:00:00 EDT 2013
Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.
The Journal of clinical investigation
Pozo N,Zahonero C,Fernández P,Liñares JM,Ayuso A,Hagiwara M,Pérez A,Ricoy JR,Hernández-Laín A,Sepúlveda JM,Sánchez-Gómez P
Sat Jun 01 00:00:00 EDT 2013
Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells.
The Journal of clinical investigation
Chen X,Ying Z,Lin X,Lin H,Wu J,Li M,Song L
Sat Jun 01 00:00:00 EDT 2013
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
The Journal of clinical investigation
Niola F,Zhao X,Singh D,Sullivan R,Castano A,Verrico A,Zoppoli P,Friedmann-Morvinski D,Sulman E,Barrett L,Zhuang Y,Verma I,Benezra R,Aldape K,Iavarone A,Lasorella A
Tue Jan 01 00:00:00 EST 2013
Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells.
The Journal of clinical investigation
Al-Aidaroos AQ,Yuen HF,Guo K,Zhang SD,Chung TH,Chng WJ,Zeng Q
Thu Aug 01 00:00:00 EDT 2013
Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Anacker C,Cattaneo A,Musaelyan K,Zunszain PA,Horowitz M,Molteni R,Luoni A,Calabrese F,Tansey K,Gennarelli M,Thuret S,Price J,Uher R,Riva MA,Pariante CM
Tue May 21 00:00:00 EDT 2013
Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America
Zhou J,Patel TR,Sirianni RW,Strohbehn G,Zheng MQ,Duong N,Schafbauer T,Huttner AJ,Huang Y,Carson RE,Zhang Y,Sullivan DJ,Piepmeier JM,Saltzman WM
Tue Jul 16 00:00:00 EDT 2013
Transforming mutations of RAC guanosine triphosphatases in human cancers.
Proceedings of the National Academy of Sciences of the United States of America
Kawazu M,Ueno T,Kontani K,Ogita Y,Ando M,Fukumura K,Yamato A,Soda M,Takeuchi K,Miki Y,Yamaguchi H,Yasuda T,Naoe T,Yamashita Y,Katada T,Choi YL,Mano H
Tue Feb 19 00:00:00 EST 2013
Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.
Proceedings of the National Academy of Sciences of the United States of America
Britschgi A,Bill A,Brinkhaus H,Rothwell C,Clay I,Duss S,Rebhan M,Raman P,Guy CT,Wetzel K,George E,Popa MO,Lilley S,Choudhury H,Gosling M,Wang L,Fitzgerald S,Borawski J,Baffoe J,Labow M,Gaither LA,Bentires-Alj M
Tue Mar 12 00:00:00 EDT 2013
PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.
Proceedings of the National Academy of Sciences of the United States of America
Iwanami A,Gini B,Zanca C,Matsutani T,Assuncao A,Nael A,Dang J,Yang H,Zhu S,Kohyama J,Kitabayashi I,Cavenee WK,Cloughesy TF,Furnari FB,Nakamura M,Toyama Y,Okano H,Mischel PS
Tue Mar 12 00:00:00 EDT 2013
Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1.
Proceedings of the National Academy of Sciences of the United States of America
Fan R,Kim NG,Gumbiner BM
Tue Feb 12 00:00:00 EST 2013
Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Gu X,Yu JJ,Ilter D,Blenis N,Henske EP,Blenis J
Tue Sep 10 00:00:00 EDT 2013
Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles.
Proceedings of the National Academy of Sciences of the United States of America
Hikichi T,Matoba R,Ikeda T,Watanabe A,Yamamoto T,Yoshitake S,Tamura-Nakano M,Kimura T,Kamon M,Shimura M,Kawakami K,Okuda A,Okochi H,Inoue T,Suzuki A,Masui S
Tue Apr 16 00:00:00 EDT 2013
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 EDT 2013
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
Proceedings of the National Academy of Sciences of the United States of America
Smith MJ,Neel BG,Ikura M
Tue Mar 19 00:00:00 EDT 2013
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
Proceedings of the National Academy of Sciences of the United States of America
Smith MJ,Neel BG,Ikura M
Tue Mar 19 00:00:00 EDT 2013
Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation.
Proceedings of the National Academy of Sciences of the United States of America
Galick HA,Kathe S,Liu M,Robey-Bond S,Kidane D,Wallace SS,Sweasy JB
Tue Aug 27 00:00:00 EDT 2013
The prolyl-isomerase Pin1 activates the mitochondrial death program of p53.
Cell death and differentiation
Sorrentino G,Mioni M,Giorgi C,Ruggeri N,Pinton P,Moll U,Mantovani F,Del Sal G
Fri Feb 01 00:00:00 EST 2013
Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme.
Oncogene
Wang Y,Moncayo G,Morin P,Xue G,Grzmil M,Lino MM,Clément-Schatlo V,Frank S,Merlo A,Hemmings BA
Thu Feb 14 00:00:00 EST 2013
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.
The Journal of cell biology
Ahmed Z,Lin CC,Suen KM,Melo FA,Levitt JA,Suhling K,Ladbury JE
Mon Feb 18 00:00:00 EST 2013
Zac1 regulates astroglial differentiation of neural stem cells through Socs3.
Stem cells (Dayton, Ohio)
Schmidt-Edelkraut U,Hoffmann A,Daniel G,Spengler D
Thu Aug 01 00:00:00 EDT 2013
Zac1 regulates astroglial differentiation of neural stem cells through Socs3.
Stem cells (Dayton, Ohio)
Schmidt-Edelkraut U,Hoffmann A,Daniel G,Spengler D
Thu Aug 01 00:00:00 EDT 2013
MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.
Stem cells (Dayton, Ohio)
Joshi K,Banasavadi-Siddegowda Y,Mo X,Kim SH,Mao P,Kig C,Nardini D,Sobol RW,Chow LM,Kornblum HI,Waclaw R,Beullens M,Nakano I
Sat Jun 01 00:00:00 EDT 2013
IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.
Stem cells (Dayton, Ohio)
Osuka S,Sampetrean O,Shimizu T,Saga I,Onishi N,Sugihara E,Okubo J,Fujita S,Takano S,Matsumura A,Saya H
Mon Apr 01 00:00:00 EDT 2013
IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.
Stem cells (Dayton, Ohio)
Osuka S,Sampetrean O,Shimizu T,Saga I,Onishi N,Sugihara E,Okubo J,Fujita S,Takano S,Matsumura A,Saya H
Mon Apr 01 00:00:00 EDT 2013
Function and mode of action of cytohesins in the epidermal growth factor pathway in colorectal cancer cells.
Oncology letters
Pan T,Sun J,Zhou J,Fu Z,Hu Y,Zheng S,Zhang S
Fri Feb 01 00:00:00 EST 2013
Glioma stem cell-targeted dendritic cells as a tumor vaccine against malignant glioma.
Yonsei medical journal
Ji B,Chen Q,Liu B,Wu L,Tian D,Guo Z,Yi W
Tue Jan 01 00:00:00 EST 2013
Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells.
PloS one
Koivuniemi R,Mäkelä J,Hokkanen ME,Bruelle C,Ho TH,Ola R,Korhonen L,Schröder J,Kataoka H,Lindholm D
Mon Jul 29 00:00:00 EDT 2013
Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model.
Journal of translational medicine
Touboul C,Lis R,Al Farsi H,Raynaud CM,Warfa M,Althawadi H,Mery E,Mirshahi M,Rafii A
Thu Jan 31 00:00:00 EST 2013
Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury.
Molecular brain
Nishimura S,Yasuda A,Iwai H,Takano M,Kobayashi Y,Nori S,Tsuji O,Fujiyoshi K,Ebise H,Toyama Y,Okano H,Nakamura M
Tue Jan 08 00:00:00 EST 2013
The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.
The Journal of biological chemistry
Capecci J,Forgac M
Fri Nov 08 00:00:00 EST 2013
Identification and characterization of cells with cancer stem cell properties in human primary lung cancer cell lines.
PloS one
Wang P,Gao Q,Suo Z,Munthe E,Solberg S,Ma L,Wang M,Westerdaal NA,Kvalheim G,Gaudernack G
Tue Aug 27 00:00:00 EDT 2013
N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.
The Journal of biological chemistry
Long PM,Moffett JR,Namboodiri AMA,Viapiano MS,Lawler SE,Jaworski DM
Fri Sep 06 00:00:00 EDT 2013
Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7.
The Journal of biological chemistry
Wu HA,Balsbaugh JL,Chandler H,Georgilis A,Zullow H,Shabanowitz J,Hunt DF,Gil J,Peters G,Bernstein E
Fri Dec 20 00:00:00 EST 2013
Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway.
The Journal of biological chemistry
Onono F,Subramanian T,Sunkara M,Subramanian KL,Spielmann HP,Morris AJ
Fri Sep 20 00:00:00 EDT 2013
Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID).
The Journal of biological chemistry
Watashi K,Liang G,Iwamoto M,Marusawa H,Uchida N,Daito T,Kitamura K,Muramatsu M,Ohashi H,Kiyohara T,Suzuki R,Li J,Tong S,Tanaka Y,Murata K,Aizaki H,Wakita T
Fri Nov 01 00:00:00 EDT 2013
Cord blood Lin(-)CD45(-) embryonic-like stem cells are a heterogeneous population that lack self-renewal capacity.
PloS one
Alvarez-Gonzalez C,Duggleby R,Vagaska B,Querol S,Gomez SG,Ferretti P,Madrigal A
AF-100-15 was used in Cell Culture to isolate, characterise and expand the embryonic-like stem cell fraction from human umbilical cord blood, showing that these embryonic-like stem cells are a heterogeneous population that lack self-renewal capacity.
Thu Apr 24 00:00:00 EDT 2014
The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance.
The Journal of biological chemistry
Whelan KA,Schwab LP,Karakashev SV,Franchetti L,Johannes GJ,Seagroves TN,Reginato MJ
Fri May 31 00:00:00 EDT 2013
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
The Journal of biological chemistry
Yamaguchi Y,Shao Z,Sharif S,Du XY,Myles T,Merchant M,Harsh G,Glantz M,Recht L,Morser J,Leung LL
Fri Feb 01 00:00:00 EST 2013
Krüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells.
PloS one
Leng Z,Tao K,Xia Q,Tan J,Yue Z,Chen J,Xi H,Li J,Zheng H
Tue Aug 27 00:00:00 EDT 2013
P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments.
PloS one
Campbell AD,Lawn S,McGarry LC,Welch HC,Ozanne BW,Norman JC
Wed Sep 04 00:00:00 EDT 2013
P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments.
PloS one
Campbell AD,Lawn S,McGarry LC,Welch HC,Ozanne BW,Norman JC
Wed Sep 04 00:00:00 EDT 2013
MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis.
BMC cancer
Akaogi K,Ono W,Hayashi Y,Kishimoto H,Yanagisawa J
Thu Feb 07 00:00:00 EST 2013
A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation.
PloS one
Nieto-Estévez V,Pignatelli J,Araúzo-Bravo MJ,Hurtado-Chong A,Vicario-Abejón C
Tue Jul 02 00:00:00 EDT 2013
A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice.
The Journal of biological chemistry
Hennen E,Safina D,Haussmann U,Wörsdörfer P,Edenhofer F,Poetsch A,Faissner A
Fri Jun 07 00:00:00 EDT 2013
Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress.
Scientific reports
Yang PM,Lin YT,Shun CT,Lin SH,Wei TT,Chuang SH,Wu MS,Chen CC
Thu Nov 14 00:00:00 EST 2013
Cancer-initiating cells derived from human rectal adenocarcinoma tissues carry mesenchymal phenotypes and resist drug therapies.
Cell death & disease
Fan CW,Chen T,Shang YN,Gu YZ,Zhang SL,Lu R,OuYang SR,Zhou X,Li Y,Meng WT,Hu JK,Lu Y,Sun XF,Bu H,Zhou ZG,Mo XM
Thu Oct 03 00:00:00 EDT 2013
Cancer-initiating cells derived from human rectal adenocarcinoma tissues carry mesenchymal phenotypes and resist drug therapies.
Cell death & disease
Fan CW,Chen T,Shang YN,Gu YZ,Zhang SL,Lu R,OuYang SR,Zhou X,Li Y,Meng WT,Hu JK,Lu Y,Sun XF,Bu H,Zhou ZG,Mo XM
Thu Oct 03 00:00:00 EDT 2013
Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression.
The Journal of biological chemistry
Chandra A,Lan S,Zhu J,Siclari VA,Qin L
Fri Jul 12 00:00:00 EDT 2013
Downregulation of ubiquitin level via knockdown of polyubiquitin gene Ubb as potential cancer therapeutic intervention.
Scientific reports
Oh C,Park S,Lee EK,Yoo YJ
Mon Jun 23 00:00:00 EDT 2014
Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity.
Cell death & disease
Lefebvre J,Muharram G,Leroy C,Kherrouche Z,Montagne R,Ichim G,Tauszig-Delamasure S,Chotteau-Lelievre A,Brenner C,Mehlen P,Tulasne D
Thu Oct 17 00:00:00 EDT 2013
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.
Cell death & disease
Lundholm L,Hååg P,Zong D,Juntti T,Mörk B,Lewensohn R,Viktorsson K
Thu Jan 31 00:00:00 EST 2013
EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells.
Cell death & disease
Rea K,Sensi M,Anichini A,Canevari S,Tomassetti A
Thu Oct 03 00:00:00 EDT 2013
Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.
PloS one
McNamara CR,Ahuja R,Osafo-Addo AD,Barrows D,Kettenbach A,Skidan I,Teng X,Cuny GD,Gerber S,Degterev A
Tue Aug 27 00:00:00 EDT 2013
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Nature
Wilson TR,Fridlyand J,Yan Y,Penuel E,Burton L,Chan E,Peng J,Lin E,Wang Y,Sosman J,Ribas A,Li J,Moffat J,Sutherlin DP,Koeppen H,Merchant M,Neve R,Settleman J
Thu Jul 26 00:00:00 EDT 2012
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
Nature
Turcan S,Rohle D,Goenka A,Walsh LA,Fang F,Yilmaz E,Campos C,Fabius AW,Lu C,Ward PS,Thompson CB,Kaufman A,Guryanova O,Levine R,Heguy A,Viale A,Morris LG,Huse JT,Mellinghoff IK,Chan TA
Wed Feb 15 00:00:00 EST 2012
A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy.
Cell
Cabianca DS,Casa V,Bodega B,Xynos A,Ginelli E,Tanaka Y,Gabellini D
Fri May 11 00:00:00 EDT 2012
Scanning angle interference microscopy reveals cell dynamics at the nanoscale.
Nature methods
Paszek MJ,DuFort CC,Rubashkin MG,Davidson MW,Thorn KS,Liphardt JT,Weaver VM
Sun Jul 01 00:00:00 EDT 2012
A mouse model of the most aggressive subgroup of human medulloblastoma.
Cancer cell
Kawauchi D,Robinson G,Uziel T,Gibson P,Rehg J,Gao C,Finkelstein D,Qu C,Pounds S,Ellison DW,Gilbertson RJ,Roussel MF
Tue Feb 14 00:00:00 EST 2012
The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas.
Cancer cell
Binda E,Visioli A,Giani F,Lamorte G,Copetti M,Pitter KL,Huse JT,Cajola L,Zanetti N,DiMeco F,De Filippis L,Mangiola A,Maira G,Anile C,De Bonis P,Reynolds BA,Pasquale EB,Vescovi AL
Tue Dec 11 00:00:00 EST 2012
Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach.
Molecular therapy : the journal of the American Society of Gene Therapy
Moschidou D,Mukherjee S,Blundell MP,Drews K,Jones GN,Abdulrazzak H,Nowakowska B,Phoolchund A,Lay K,Ramasamy TS,Cananzi M,Nettersheim D,Sullivan M,Frost J,Moore G,Vermeesch JR,Fisk NM,Thrasher AJ,Atala A,Adjaye J,Schorle H,De Coppi P,Guillot PV
Mon Oct 01 00:00:00 EDT 2012
Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America
Omori E,Inagaki M,Mishina Y,Matsumoto K,Ninomiya-Tsuji J
Tue Feb 28 00:00:00 EST 2012
Detection of a rare BCR-ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS).
Proceedings of the National Academy of Sciences of the United States of America
Breitkopf SB,Yuan M,Pihan GA,Asara JM
Tue Oct 02 00:00:00 EDT 2012
Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel.
Proceedings of the National Academy of Sciences of the United States of America
Ashraf SQ,Nicholls AM,Wilding JL,Ntouroupi TG,Mortensen NJ,Bodmer WF
Tue Dec 18 00:00:00 EST 2012
Long-range mechanical force enables self-assembly of epithelial tubular patterns.
Proceedings of the National Academy of Sciences of the United States of America
Guo CL,Ouyang M,Yu JY,Maslov J,Price A,Shen CY
Tue Apr 10 00:00:00 EDT 2012
Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer.
Oncogene
Alberti C,Pinciroli P,Valeri B,Ferri R,Ditto A,Umezawa K,Sensi M,Canevari S,Tomassetti A
Thu Sep 13 00:00:00 EDT 2012
EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis.
Cell proliferation
Feng Y,Dai X,Li X,Wang H,Liu J,Zhang J,Du Y,Xia L
Mon Oct 01 00:00:00 EDT 2012
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.
The Journal of cell biology
Elbediwy A,Zihni C,Terry SJ,Clark P,Matter K,Balda MS
Mon Aug 20 00:00:00 EDT 2012
Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation.
PLoS pathogens
Wu X,Robotham JM,Lee E,Dalton S,Kneteman NM,Gilbert DM,Tang H
Mon Aug 20 00:00:00 EDT 2012
Treatment of breast cancer stem cells with oncolytic herpes simplex virus.
Cancer gene therapy
Li J,Zeng W,Huang Y,Zhang Q,Hu P,Rabkin SD,Liu R
Mon Oct 01 00:00:00 EDT 2012
Rai is a new regulator of neural progenitor migration and glioblastoma invasion.
Stem cells (Dayton, Ohio)
Ortensi B,Osti D,Pellegatta S,Pisati F,Brescia P,Fornasari L,Levi D,Gaetani P,Colombo P,Ferri A,Nicolis S,Finocchiaro G,Pelicci G
Tue May 01 00:00:00 EDT 2012
Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties.
Stem cells (Dayton, Ohio)
Sarrio D,Franklin CK,Mackay A,Reis-Filho JS,Isacke CM
Wed Feb 01 00:00:00 EST 2012
IGF-II promotes stemness of neural restricted precursors.
Stem cells (Dayton, Ohio)
Ziegler AN,Schneider JS,Qin M,Tyler WA,Pintar JE,Fraidenraich D,Wood TL,Levison SW
Fri Jun 01 00:00:00 EDT 2012
Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity.
Stem cells (Dayton, Ohio)
Voon DC,Wang H,Koo JK,Nguyen TA,Hor YT,Chu YS,Ito K,Fukamachi H,Chan SL,Thiery JP,Ito Y
Mon Oct 01 00:00:00 EDT 2012
Grafted neuronal precursor cells differentiate and integrate in injured hippocampus in experimental pneumococcal meningitis.
Stem cells (Dayton, Ohio)
Hofer S,Magloire V,Streit J,Leib SL
Fri Jun 01 00:00:00 EDT 2012
Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease.
Experimental neurology
Sadan O,Shemesh N,Barzilay R,Dadon-Nahum M,Blumenfeld-Katzir T,Assaf Y,Yeshurun M,Djaldetti R,Cohen Y,Melamed E,Offen D
Sun Apr 01 00:00:00 EDT 2012
Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Swanson CD,Akama-Garren EH,Stein EA,Petralia JD,Ruiz PJ,Edalati A,Lindstrom TM,Robinson WH
Sun Apr 01 00:00:00 EDT 2012
Sca-1 is involved in the adhesion of myosphere cells to αVβ3 integrin.
Biology open
Penvose A,Westerman KA
Sat Sep 15 00:00:00 EDT 2012
Isolation and biological characterization of chicken amnion epithelial cells.
European journal of histochemistry : EJH
Gao Y,Pu Y,Wang D,Hou L,Guan W,Ma Y
Wed Aug 29 00:00:00 EDT 2012
Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.
The Journal of biological chemistry
Lu C,Mi LZ,Schürpf T,Walz T,Springer TA
Fri Nov 02 00:00:00 EDT 2012
Targeting JNK for therapeutic depletion of stem-like glioblastoma cells.
Scientific reports
Matsuda K,Sato A,Okada M,Shibuya K,Seino S,Suzuki K,Watanabe E,Narita Y,Shibui S,Kayama T,Kitanaka C
Sun Mar 17 00:00:00 EDT 2013
Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma.
PloS one
Lou E,Fujisawa S,Morozov A,Barlas A,Romin Y,Dogan Y,Gholami S,Moreira AL,Manova-Todorova K,Moore MA
Mon Aug 20 00:00:00 EDT 2012
Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease.
BMC neuroscience
El-Akabawy G,Rattray I,Johansson SM,Gale R,Bates G,Modo M
Thu Aug 09 00:00:00 EDT 2012
Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.
PloS one
Danova-Alt R,Heider A,Egger D,Cross M,Alt R
Tue Aug 07 00:00:00 EDT 2012
Differential gene expression profile associated with the abnormality of bone marrow mesenchymal stem cells in aplastic anemia.
PloS one
Li J,Yang S,Lu S,Zhao H,Feng J,Li W,Ma F,Ren Q,Liu B,Zhang L,Zheng Y,Han ZC
Thu Apr 25 00:00:00 EDT 2013
Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling.
The Journal of biological chemistry
Zhang W,Mendoza MC,Pei X,Ilter D,Mahoney SJ,Zhang Y,Ma D,Blenis J,Wang Y
Fri Apr 06 00:00:00 EDT 2012
Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy.
PloS one
Joshi AD,Loilome W,Siu IM,Tyler B,Gallia GL,Riggins GJ
Tue Apr 02 00:00:00 EDT 2013
Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics.
PloS one
Ferro F,Spelat R,D'Aurizio F,Puppato E,Pandolfi M,Beltrami AP,Cesselli D,Falini G,Beltrami CA,Curcio F
Wed Nov 28 00:00:00 EST 2012
HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ΔNp63.
PloS one
Yan W,Zhang Y,Zhang J,Cho SJ,Chen X
Mon Feb 25 00:00:00 EST 2013
Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion.
PloS one
Yoshimoto AN,Bernardazzi C,Carneiro AJ,Elia CC,Martinusso CA,Ventura GM,Castelo-Branco MT,de Souza HS
Mon Feb 25 00:00:00 EST 2013
Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells.
BMC cancer
Monticone M,Daga A,Candiani S,Romeo F,Mirisola V,Viaggi S,Melloni I,Pedemonte S,Zona G,Giaretti W,Pfeffer U,Castagnola P
Fri Aug 17 00:00:00 EDT 2012
Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors.
PloS one
Kawamura K,Chen Y,Shu Y,Cheng Y,Qiao J,Behr B,Pera RA,Hsueh AJ
Tue May 07 00:00:00 EDT 2013
Immunotherapy against the radial glia marker GLAST effectively triggers specific antitumor effectors without autoimmunity.
Oncoimmunology
Cantini G,Pisati F,Pessina S,Finocchiaro G,Pellegatta S
Sat Sep 01 00:00:00 EDT 2012
Efficient derivation of multipotent neural stem/progenitor cells from non-human primate embryonic stem cells.
PloS one
Shimada H,Okada Y,Ibata K,Ebise H,Ota S,Tomioka I,Nomura T,Maeda T,Kohda K,Yuzaki M,Sasaki E,Nakamura M,Okano H
Mon May 06 00:00:00 EDT 2013
Myoferlin depletion in breast cancer cells promotes mesenchymal to epithelial shape change and stalls invasion.
PloS one
Li R,Ackerman WE,Mihai C,Volakis LI,Ghadiali S,Kniss DA
Fri Jan 04 00:00:00 EST 2013
Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells.
PloS one
Tabara K,Kanda R,Sonoda K,Kubo T,Murakami Y,Kawahara A,Azuma K,Abe H,Kage M,Yoshinaga A,Tahira T,Hayashi K,Arao T,Nishio K,Rosell R,Kuwano M,Ono M
Wed Jan 16 00:00:00 EST 2013
Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma.
Molecular systems biology
Setty M,Helmy K,Khan AA,Silber J,Arvey A,Neezen F,Agius P,Huse JT,Holland EC,Leslie CS
Mon Jan 14 00:00:00 EST 2013
Enhanced PKCδ and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF.
PloS one
Chen YJ,Tsai RK,Wu WC,He MS,Kao YH,Wu WS
Tue Mar 05 00:00:00 EST 2013
Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons.
PloS one
Park TI,Monzo H,Mee EW,Bergin PS,Teoh HH,Montgomery JM,Faull RL,Curtis MA,Dragunow M
Thu Oct 11 00:00:00 EDT 2012
The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).
The Journal of biological chemistry
Foveau B,Boulay G,Pinte S,Van Rechem C,Rood BR,Leprince D
Fri Feb 17 00:00:00 EST 2012
The early postnatal nonhuman primate neocortex contains self-renewing multipotent neural progenitor cells.
PloS one
Homman-Ludiye J,Merson TD,Bourne JA
Fri Aug 03 00:00:00 EDT 2012
Characterization and retinal neuron differentiation of WERI-Rb1 cancer stem cells.
Molecular vision
Hu H,Deng F,Liu Y,Chen M,Zhang X,Sun X,Dong Z,Liu X,Ge J
Tue Jan 29 00:00:00 EST 2013
Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.
The Journal of biological chemistry
Malik R,Soh UJ,Trejo J,Marchese A
Fri Mar 16 00:00:00 EDT 2012
Bio-imaging of colorectal cancer models using near infrared labeled epidermal growth factor.
PloS one
Cohen G,Lecht S,Arien-Zakay H,Ettinger K,Amsalem O,Oron-Herman M,Yavin E,Prus D,Benita S,Nissan A,Lazarovici P
Thu May 23 00:00:00 EDT 2013
Bio-imaging of colorectal cancer models using near infrared labeled epidermal growth factor.
PloS one
Cohen G,Lecht S,Arien-Zakay H,Ettinger K,Amsalem O,Oron-Herman M,Yavin E,Prus D,Benita S,Nissan A,Lazarovici P
Thu May 23 00:00:00 EDT 2013
Bio-imaging of colorectal cancer models using near infrared labeled epidermal growth factor.
PloS one
Cohen G,Lecht S,Arien-Zakay H,Ettinger K,Amsalem O,Oron-Herman M,Yavin E,Prus D,Benita S,Nissan A,Lazarovici P
Thu May 23 00:00:00 EDT 2013
E2F mediates enhanced alternative polyadenylation in proliferation.
Genome biology
Elkon R,Drost J,van Haaften G,Jenal M,Schrier M,Oude Vrielink JA,Agami R
Mon Jul 02 00:00:00 EDT 2012
Regulation of the ligand-dependent activation of the epidermal growth factor receptor by calmodulin.
The Journal of biological chemistry
Li H,Panina S,Kaur A,Ruano MJ,Sánchez-González P,la Cour JM,Stephan A,Olesen UH,Berchtold MW,Villalobo A
Fri Jan 27 00:00:00 EST 2012
Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells.
Journal of translational medicine
Heinrich EL,Lee W,Lu J,Lowy AM,Kim J
Mon Apr 02 00:00:00 EDT 2012
miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma.
BMC cancer
Põlajeva J,Swartling FJ,Jiang Y,Singh U,Pietras K,Uhrbom L,Westermark B,Roswall P
Wed Aug 29 00:00:00 EDT 2012
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
The Journal of biological chemistry
Liu Q,Kirubakaran S,Hur W,Niepel M,Westover K,Thoreen CC,Wang J,Ni J,Patricelli MP,Vogel K,Riddle S,Waller DL,Traynor R,Sanda T,Zhao Z,Kang SA,Zhao J,Look AT,Sorger PK,Sabatini DM,Gray NS
Fri Mar 23 00:00:00 EDT 2012
Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.
PloS one
Bill A,Schmitz A,König K,Heukamp LC,Hannam JS,Famulok M
Wed Jan 16 00:00:00 EST 2013
Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion.
Molecular cancer
Wu Q,Dhir R,Wells A
Wed Jan 11 00:00:00 EST 2012
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
PloS one
Muto J,Imai T,Ogawa D,Nishimoto Y,Okada Y,Mabuchi Y,Kawase T,Iwanami A,Mischel PS,Saya H,Yoshida K,Matsuzaki Y,Okano H
Mon Aug 20 00:00:00 EDT 2012
Radiation-Triggered NF-κB Activation is Responsible for the Angiogenic Signaling Pathway and Neovascularization for Breast Cancer Cell Proliferation and Growth.
Breast cancer : basic and clinical research
Yu H,Mohan S,Natarajan M
Thu Aug 23 00:00:00 EDT 2012
Gene expression profile of adult human olfactory bulb and embryonic neural stem cell suggests distinct signaling pathways and epigenetic control.
PloS one
Marei HE,Ahmed AE,Michetti F,Pescatori M,Pallini R,Casalbore P,Cenciarelli C,Elhadidy M
Fri Jul 27 00:00:00 EDT 2012
JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency.
Nature communications
van Oosten AL,Costa Y,Smith A,Silva JC
Tue May 08 00:00:00 EDT 2012
Involvement of Girdin in the determination of cell polarity during cell migration.
PloS one
Ohara K,Enomoto A,Kato T,Hashimoto T,Isotani-Sakakibara M,Asai N,Ishida-Takagishi M,Weng L,Nakayama M,Watanabe T,Kato K,Kaibuchi K,Murakumo Y,Hirooka Y,Goto H,Takahashi M
Mon Sep 10 00:00:00 EDT 2012
Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells.
Cell communication and signaling : CCS
Zuehlke J,Ebenau A,Krueger B,Goppelt-Struebe M
Sun Sep 02 00:00:00 EDT 2012
A resealed-cell system for analyzing pathogenic intracellular events: perturbation of endocytic pathways under diabetic conditions.
PloS one
Kano F,Nakatsu D,Noguchi Y,Yamamoto A,Murata M
Thu Feb 07 00:00:00 EST 2013
ELL facilitates RNA polymerase II pause site entry and release.
Nature communications
Byun JS,Fufa TD,Wakano C,Fernandez A,Haggerty CM,Sung MH,Gardner K
Tue Jan 17 00:00:00 EST 2012
Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN.
PloS one
Han M,Liu M,Wang Y,Chen X,Xu J,Sun Y,Zhao L,Qu H,Fan Y,Wu C
Thu Mar 21 00:00:00 EDT 2013
Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
PloS one
Lin SP,Lee YT,Wang JY,Miller SA,Chiou SH,Hung MC,Hung SC
Wed May 22 00:00:00 EDT 2013
Mammary epithelial cell polarity is regulated differentially by p73 isoforms via epithelial-to-mesenchymal transition.
The Journal of biological chemistry
Zhang Y,Yan W,Jung YS,Chen X
Fri May 18 00:00:00 EDT 2012
Direct stimulation of adult neural stem/progenitor cells in vitro and neurogenesis in vivo by salvianolic acid B.
PloS one
Zhuang P,Zhang Y,Cui G,Bian Y,Zhang M,Zhang J,Liu Y,Yang X,Isaiah AO,Lin Y,Jiang Y
Mon Aug 27 00:00:00 EDT 2012
Nuclear translocation of β-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype.
PloS one
Herencia C,Martínez-Moreno JM,Herrera C,Corrales F,Santiago-Mora R,Espejo I,Barco M,Almadén Y,de la Mata M,Rodríguez-Ariza A,Muñoz-Castañeda JR
Wed Oct 17 00:00:00 EDT 2012
Loss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells.
The Journal of biological chemistry
Wang PS,Wang J,Zheng Y,Pallen CJ
Fri Apr 06 00:00:00 EDT 2012
Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling.
PloS one
Torres J,Prieto J,Durupt FC,Broad S,Watt FM
Tue Sep 04 00:00:00 EDT 2012
S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.
PloS one
Lacar B,Herman P,Hartman NW,Hyder F,Bordey A
Fri Aug 03 00:00:00 EDT 2012
Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.
PloS one
Zhu R,Yang Y,Tian Y,Bai J,Zhang X,Li X,Peng Z,He Y,Chen L,Pan Q,Fang D,Chen W,Qian C,Bian X,Wang R
Mon Aug 27 00:00:00 EDT 2012
Mosaic analysis with double markers reveals tumor cell of origin in glioma.
Cell
Liu C,Sage JC,Miller MR,Verhaak RG,Hippenmeyer S,Vogel H,Foreman O,Bronson RT,Nishiyama A,Luo L,Zong H
Fri Jul 22 00:00:00 EDT 2011
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.
Cancer cell
Chang CY,Kazmin D,Jasper JS,Kunder R,Zuercher WJ,McDonnell DP
Tue Oct 18 00:00:00 EDT 2011
Hepatic differentiation of amniotic epithelial cells.
Hepatology (Baltimore, Md.)
Marongiu F,Gramignoli R,Dorko K,Miki T,Ranade AR,Paola Serra M,Doratiotto S,Sini M,Sharma S,Mitamura K,Sellaro TL,Tahan V,Skvorak KJ,Ellis EC,Badylak SF,Davila JC,Hines R,Laconi E,Strom SC
Sun May 01 00:00:00 EDT 2011
Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sciuscio D,Diserens AC,van Dommelen K,Martinet D,Jones G,Janzer RC,Pollo C,Hamou MF,Kaina B,Stupp R,Levivier M,Hegi ME
AF-100-15 was used in Cell Culture to conclude that even a low percentage of MGMT methylation measured in a glioblastoma sample may be relevant and predict benefit from an alkylating agent therapy.
Sat Jan 15 00:00:00 EST 2011
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor.
Molecular psychiatry
Anacker C,Zunszain PA,Cattaneo A,Carvalho LA,Garabedian MJ,Thuret S,Price J,Pariante CM
Fri Jul 01 00:00:00 EDT 2011
Effects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryos.
Proceedings of the National Academy of Sciences of the United States of America
Chung E,Genco MC,Megrelis L,Ruderman JV
Tue Oct 25 00:00:00 EDT 2011
Interstitial flow influences direction of tumor cell migration through competing mechanisms.
Proceedings of the National Academy of Sciences of the United States of America
Polacheck WJ,Charest JL,Kamm RD
Tue Jul 05 00:00:00 EDT 2011
The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro.
Aging cell
Liu S,Liu S,Wang X,Zhou J,Cao Y,Wang F,Duan E
Mon Aug 01 00:00:00 EDT 2011
Quantitative assays for the measurement of HER1-HER2 heterodimerization and phosphorylation in cell lines and breast tumors: applications for diagnostics and targeted drug mechanism of action.
Breast cancer research : BCR
DeFazio-Eli L,Strommen K,Dao-Pick T,Parry G,Goodman L,Winslow J
Fri Apr 15 00:00:00 EDT 2011
Neural stem cells maintain their stemness through protein kinase C ζ-mediated inhibition of TRIM32.
Stem cells (Dayton, Ohio)
Hillje AL,Worlitzer MM,Palm T,Schwamborn JC
Thu Sep 01 00:00:00 EDT 2011
MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis.
Stem cells (Dayton, Ohio)
Sato A,Sunayama J,Matsuda K,Seino S,Suzuki K,Watanabe E,Tachibana K,Tomiyama A,Kayama T,Kitanaka C
Thu Dec 01 00:00:00 EST 2011
Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment.
Stem cells (Dayton, Ohio)
Meyer JS,Howden SE,Wallace KA,Verhoeven AD,Wright LS,Capowski EE,Pinilla I,Martin JM,Tian S,Stewart R,Pattnaik B,Thomson JA,Gamm DM
Mon Aug 01 00:00:00 EDT 2011
ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.
Stem cells (Dayton, Ohio)
Romero-Grimaldi C,Murillo-Carretero M,López-Toledano MA,Carrasco M,Castro C,Estrada C
Sat Oct 01 00:00:00 EDT 2011
Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Alva JA,Lee GE,Escobar EE,Pyle AD
Thu Dec 01 00:00:00 EST 2011
CD24: a novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Jiang W,Sui X,Zhang D,Liu M,Ding M,Shi Y,Deng H
Fri Apr 01 00:00:00 EDT 2011
Neural stem cell gene therapy ameliorates pathology and function in a mouse model of globoid cell leukodystrophy.
Stem cells (Dayton, Ohio)
Neri M,Ricca A,di Girolamo I,Alcala'-Franco B,Cavazzin C,Orlacchio A,Martino S,Naldini L,Gritti A
Sat Oct 01 00:00:00 EDT 2011
Neural stem cell gene therapy ameliorates pathology and function in a mouse model of globoid cell leukodystrophy.
Stem cells (Dayton, Ohio)
Neri M,Ricca A,di Girolamo I,Alcala'-Franco B,Cavazzin C,Orlacchio A,Martino S,Naldini L,Gritti A
Sat Oct 01 00:00:00 EDT 2011
Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells.
Bioscience reports
Gaviraghi M,Tunici P,Valensin S,Rossi M,Giordano C,Magnoni L,Dandrea M,Montagna L,Ritelli R,Scarpa A,Bakker A
Tue Feb 01 00:00:00 EST 2011
A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus.
Frontiers in neuroscience
Babu H,Claasen JH,Kannan S,Rünker AE,Palmer T,Kempermann G
Thu Nov 10 00:00:00 EST 2011
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells.
Molecular cancer
Tabuse M,Ohta S,Ohashi Y,Fukaya R,Misawa A,Yoshida K,Kawase T,Saya H,Thirant C,Chneiweiss H,Matsuzaki Y,Okano H,Kawakami Y,Toda M
Sun May 22 00:00:00 EDT 2011
Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord.
BMC neuroscience
Mamaeva D,Ripoll C,Bony C,Teigell M,Perrin FE,Rothhut B,Bieche I,Lidereau R,Privat A,Rigau V,Guillon H,Vachiery-Lahaye F,Noel D,Bauchet L,Hugnot JP
Mon Oct 10 00:00:00 EDT 2011
Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis.
BMC cancer
Nakanishi Y,Shiraha H,Nishina S,Tanaka S,Matsubara M,Horiguchi S,Iwamuro M,Takaoka N,Uemura M,Kuwaki K,Hagihara H,Toshimori J,Ohnishi H,Takaki A,Nakamura S,Kobayashi Y,Nouso K,Yagi T,Yamamoto K
Tue Jan 04 00:00:00 EST 2011
An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.
PloS one
Gil-Ranedo J,Mendiburu-Eliçabe M,García-Villanueva M,Medina D,del Álamo M,Izquierdo M
Mon Apr 23 00:00:00 EDT 2012
Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR.
PloS one
Ruiz-Ferrer M,Torroglosa A,Núñez-Torres R,de Agustín JC,Antiñolo G,Borrego S
Wed Feb 15 00:00:00 EST 2012
Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.
PloS one
Shiraki N,Yamazoe T,Qin Z,Ohgomori K,Mochitate K,Kume K,Kume S
Fri Feb 24 00:00:00 EST 2012
Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.
PloS one
Shiraki N,Yamazoe T,Qin Z,Ohgomori K,Mochitate K,Kume K,Kume S
Fri Feb 24 00:00:00 EST 2012
Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study.
PloS one
Carr CA,Stuckey DJ,Tan JJ,Tan SC,Gomes RS,Camelliti P,Messina E,Giacomello A,Ellison GM,Clarke K
Fri Apr 06 00:00:00 EDT 2012
Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.
Oncotarget
Weber GL,Parat MO,Binder ZA,Gallia GL,Riggins GJ
Tue Nov 01 00:00:00 EDT 2011
Differentiation of mesenchymal stem cells derived from pancreatic islets and bone marrow into islet-like cell phenotype.
PloS one
Zanini C,Bruno S,Mandili G,Baci D,Cerutti F,Cenacchi G,Izzi L,Camussi G,Forni M
Mon Aug 27 00:00:00 EDT 2012
Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling.
PloS one
Talbot AL,Bullock GC,Delehanty LL,Sattler M,Zhao ZJ,Goldfarb AN
Fri Feb 24 00:00:00 EST 2012
Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
PloS one
Oliver L,Hue E,Rossignol J,Bougras G,Hulin P,Naveilhan P,Heymann D,Lescaudron L,Vallette FM
Thu May 12 00:00:00 EDT 2011
Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions.
The Journal of biological chemistry
Zhang Y,Yan W,Chen X
Fri May 06 00:00:00 EDT 2011
Discovery of novel human breast cancer microRNAs from deep sequencing data by analysis of pri-microRNA secondary structures.
PloS one
Ryu S,Joshi N,McDonnell K,Woo J,Choi H,Gao D,McCombie WR,Mittal V
Tue Feb 08 00:00:00 EST 2011
Impaired OXPHOS complex III in breast cancer.
PloS one
Owens KM,Kulawiec M,Desouki MM,Vanniarajan A,Singh KK
Fri Apr 13 00:00:00 EDT 2012
IκB kinase β regulates epithelium migration during corneal wound healing.
PloS one
Chen L,Meng Q,Kao W,Xia Y
Mon Jan 17 00:00:00 EST 2011
Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells.
Molecular vision
Osada H,Yoshitake Y,Ikeda T,Ishigaki Y,Takata T,Tomosugi N,Sasaki H,Yonekura H
Thu Jan 13 00:00:00 EST 2011
Human cardiac-derived adherent proliferating cells reduce murine acute Coxsackievirus B3-induced myocarditis.
PloS one
Miteva K,Haag M,Peng J,Savvatis K,Becher PM,Seifert M,Warstat K,Westermann D,Ringe J,Sittinger M,Schultheiss HP,Tschöpe C,Van Linthout S
Mon Apr 23 00:00:00 EDT 2012
Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells.
The Journal of biological chemistry
Hernández-Varas P,Coló GP,Bartolomé RA,Paterson A,Medraño-Fernández I,Arellano-Sánchez N,Cabañas C,Sánchez-Mateos P,Lafuente EM,Boussiotis VA,Strömblad S,Teixidó J
Fri May 27 00:00:00 EDT 2011
Cancer stem-like cells enriched in Panc-1 spheres possess increased migration ability and resistance to gemcitabine.
International journal of molecular sciences
Yin T,Wei H,Gou S,Shi P,Yang Z,Zhao G,Wang C
Mon Jan 19 00:00:00 EST 2015
Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration.
PloS one
Asano E,Maeda M,Hasegawa H,Ito S,Hyodo T,Yuan H,Takahashi M,Hamaguchi M,Senga T
Mon May 21 00:00:00 EDT 2012
Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration.
PloS one
Asano E,Maeda M,Hasegawa H,Ito S,Hyodo T,Yuan H,Takahashi M,Hamaguchi M,Senga T
Mon May 21 00:00:00 EDT 2012
In vivo tracking of human neural stem cells with 19F magnetic resonance imaging.
PloS one
Boehm-Sturm P,Mengler L,Wecker S,Hoehn M,Kallur T
Mon May 21 00:00:00 EDT 2012
The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation.
Aging
Brett JO,Renault VM,Rafalski VA,Webb AE,Brunet A
Tue Feb 01 00:00:00 EST 2011
Network modeling of the transcriptional effects of copy number aberrations in glioblastoma.
Molecular systems biology
Jörnsten R,Abenius T,Kling T,Schmidt L,Johansson E,Nordling TE,Nordlander B,Sander C,Gennemark P,Funa K,Nilsson B,Lindahl L,Nelander S
Tue Apr 26 00:00:00 EDT 2011
Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells.
ASN neuro
Yanagisawa M,Yoshimura S,Yu RK
Thu Apr 07 00:00:00 EDT 2011
Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein.
The Journal of biological chemistry
Ikushima H,Todo T,Ino Y,Takahashi M,Saito N,Miyazawa K,Miyazono K
Fri Dec 02 00:00:00 EST 2011
PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells.
Oncotarget
Siu A,Virtanen C,Jongstra J
Thu Dec 01 00:00:00 EST 2011
Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression.
BMC cancer
Zhang Y,Gonzalez RM,Zangar RC
Mon Feb 14 00:00:00 EST 2011
Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model.
Stem cell research & therapy
Watts AE,Yeager AE,Kopyov OV,Nixon AJ
Thu Jan 27 00:00:00 EST 2011
Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts.
Molecular & cellular proteomics : MCP
Kim HD,Meyer AS,Wagner JP,Alford SK,Wells A,Gertler FB,Lauffenburger DA
Tue Nov 01 00:00:00 EDT 2011
Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells.
The Journal of biological chemistry
Park BH,Lee SB,Stolz DB,Lee YJ,Lee BC
Fri Jun 03 00:00:00 EDT 2011
Expression profiling of FSHD-1 and FSHD-2 cells during myogenic differentiation evidences common and distinctive gene dysregulation patterns.
PloS one
Cheli S,François S,Bodega B,Ferrari F,Tenedini E,Roncaglia E,Ferrari S,Ginelli E,Meneveri R
Fri Oct 21 00:00:00 EDT 2011
Cytohesins are cytoplasmic ErbB receptor activators.
Cell
Bill A,Schmitz A,Albertoni B,Song JN,Heukamp LC,Walrafen D,Thorwirth F,Verveer PJ,Zimmer S,Meffert L,Schreiber A,Chatterjee S,Thomas RK,Ullrich RT,Lang T,Famulok M
Fri Oct 15 00:00:00 EDT 2010
TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma.
Cancer cell
Anido J,Sáez-Borderías A,Gonzàlez-Juncà A,Rodón L,Folch G,Carmona MA,Prieto-Sánchez RM,Barba I,Martínez-Sáez E,Prudkin L,Cuartas I,Raventós C,Martínez-Ricarte F,Poca MA,García-Dorado D,Lahn MM,Yingling JM,Rodón J,Sahuquillo J,Baselga J,Seoane J
Tue Dec 14 00:00:00 EST 2010
Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury.
The Journal of clinical investigation
Abematsu M,Tsujimura K,Yamano M,Saito M,Kohno K,Kohyama J,Namihira M,Komiya S,Nakashima K
Wed Sep 01 00:00:00 EDT 2010
The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells.
The Journal of clinical investigation
Fernando RI,Litzinger M,Trono P,Hamilton DH,Schlom J,Palena C
Mon Feb 01 00:00:00 EST 2010
Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].
Proceedings of the National Academy of Sciences of the United States of America
Wang Y,Kelber JA,Tran Cao HS,Cantin GT,Lin R,Wang W,Kaushal S,Bristow JM,Edgington TS,Hoffman RM,Bouvet M,Yates JR,Klemke RL
Tue Jun 15 00:00:00 EDT 2010
Tailored cancer immunotherapy using combinations of chemotherapy and a mixture of antibodies against EGF-receptor ligands.
Proceedings of the National Academy of Sciences of the United States of America
Lindzen M,Lavi S,Leitner O,Yarden Y
Tue Jul 13 00:00:00 EDT 2010
Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells.
Proceedings of the National Academy of Sciences of the United States of America
Kujuro Y,Suzuki N,Kondo T
Tue May 04 00:00:00 EDT 2010
Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas.
Proceedings of the National Academy of Sciences of the United States of America
Rovira M,Scott SG,Liss AS,Jensen J,Thayer SP,Leach SD
Tue Jan 05 00:00:00 EST 2010
Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture.
Angiogenesis
Trapp V,Parmakhtiar B,Papazian V,Willmott L,Fruehauf JP
Wed Dec 01 00:00:00 EST 2010
Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.
Oncogene
Thoennissen NH,O'Kelly J,Lu D,Iwanski GB,La DT,Abbassi S,Leiter A,Karlan B,Mehta R,Koeffler HP
Thu Jan 14 00:00:00 EST 2010
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy.
The Journal of cell biology
Di Bartolomeo S,Corazzari M,Nazio F,Oliverio S,Lisi G,Antonioli M,Pagliarini V,Matteoni S,Fuoco C,Giunta L,D'Amelio M,Nardacci R,Romagnoli A,Piacentini M,Cecconi F,Fimia GM
Mon Oct 04 00:00:00 EDT 2010
Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin.
The Journal of investigative dermatology
Stoll SW,Johnson JL,Bhasin A,Johnston A,Gudjonsson JE,Rittié L,Elder JT
Fri Jan 01 00:00:00 EST 2010
Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells.
Endocrine-related cancer
Santer FR,Malinowska K,Culig Z,Cavarretta IT
Mon Mar 01 00:00:00 EST 2010
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.
Stem cells (Dayton, Ohio)
Sunayama J,Matsuda K,Sato A,Tachibana K,Suzuki K,Narita Y,Shibui S,Sakurada K,Kayama T,Tomiyama A,Kitanaka C
Mon Nov 01 00:00:00 EDT 2010
Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Martina E,Degen M,Rüegg C,Merlo A,Lino MM,Chiquet-Ehrismann R,Brellier F
Mon Mar 01 00:00:00 EST 2010
Using a neodymium magnet to target delivery of ferumoxide-labeled human neural stem cells in a rat model of focal cerebral ischemia.
Human gene therapy
Song M,Kim YJ,Kim YH,Roh J,Kim SU,Yoon BW
Sat May 01 00:00:00 EDT 2010
Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response.
Investigational new drugs
Ma BB,Lui VW,Poon FF,Wong SC,To KF,Wong E,Chen H,Lo KW,Tao Q,Chan AT,Ng MH,Cheng SH
Tue Jun 01 00:00:00 EDT 2010
Telomere attrition occurs during ex vivo expansion of human dental pulp stem cells.
Journal of biomedicine & biotechnology
Mokry J,Soukup T,Micuda S,Karbanova J,Visek B,Brcakova E,Suchanek J,Bouchal J,Vokurkova D,Ivancakova R
Wed May 18 00:00:00 EDT 2011
Polysialic acid neural cell adhesion molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines.
BMC cancer
Amoureux MC,Coulibaly B,Chinot O,Loundou A,Metellus P,Rougon G,Figarella-Branger D
Wed Mar 10 00:00:00 EST 2010
Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent apoptosis, but are insensitive to direct activation with exogenous Fas ligand.
PloS one
Humphreys EH,Williams KT,Adams DH,Afford SC
Wed Nov 17 00:00:00 EST 2010
VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta.
PloS one
Holmes K,Chapman E,See V,Cross MJ
Tue Jul 06 00:00:00 EDT 2010
Mild hypoxia enhances proliferation and multipotency of human neural stem cells.
PloS one
Santilli G,Lamorte G,Carlessi L,Ferrari D,Rota Nodari L,Binda E,Delia D,Vescovi AL,De Filippis L
Tue Jan 05 00:00:00 EST 2010
Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs.
PloS one
Andersson T,Rahman S,Sansom SN,Alsiö JM,Kaneda M,Smith J,O'Carroll D,Tarakhovsky A,Livesey FJ
Mon Oct 18 00:00:00 EDT 2010
In vitro and in vivo characterization of highly purified human mesothelioma derived cells.
BMC cancer
Melotti A,Daga A,Marubbi D,Zunino A,Mutti L,Corte G
Mon Feb 22 00:00:00 EST 2010
Effect of all-trans retinoic acid on the proliferation and differentiation of brain tumor stem cells.
Journal of experimental & clinical cancer research : CR
Niu CS,Li MW,Ni YF,Chen JM,Mei JM,Li J,Fu XM
Tue Aug 17 00:00:00 EDT 2010
EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal stem cells.
BMC molecular biology
Curtis KM,Gomez LA,Rios C,Garbayo E,Raval AP,Perez-Pinzon MA,Schiller PC
Tue Aug 17 00:00:00 EDT 2010
Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.
BMC cancer
Xu Z,Zhang Y,Jiang J,Yang Y,Shi R,Hao B,Zhang Z,Huang Z,Kim JW,Zhang G
Tue Apr 27 00:00:00 EDT 2010
Dynamic interaction networks in a hierarchically organized tissue.
Molecular systems biology
Kirouac DC,Ito C,Csaszar E,Roch A,Yu M,Sykes EA,Bader GD,Zandstra PW
Tue Oct 05 00:00:00 EDT 2010
Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine.
The Journal of biological chemistry
Honda A,Hirose M,Hatori M,Matoba S,Miyoshi H,Inoue K,Ogura A
Fri Oct 08 00:00:00 EDT 2010
Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.
The Journal of biological chemistry
Prieto-Echagüe V,Gucwa A,Craddock BP,Brown DA,Miller WT
Fri Apr 02 00:00:00 EDT 2010
Apotransferrin-induced recovery after hypoxic/ischaemic injury on myelination.
ASN neuro
Guardia Clausi M,Pasquini LA,Soto EF,Pasquini JM
Fri Nov 19 00:00:00 EST 2010
Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells.
The Journal of biological chemistry
Yuan T,Wang Y,Zhao ZJ,Gu H
Fri May 14 00:00:00 EDT 2010
The antiproliferative effects of somatostatin receptor subtype 2 in breast cancer cells.
Acta pharmacologica Sinica
He Y,Yuan XM,Lei P,Wu S,Xing W,Lan XL,Zhu HF,Huang T,Wang GB,An R,Zhang YX,Shen GX
Wed Jul 01 00:00:00 EDT 2009
Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Griffiths MR,Neal JW,Fontaine M,Das T,Gasque P
Wed Apr 01 00:00:00 EDT 2009
NK cells recognize and kill human glioblastoma cells with stem cell-like properties.
Journal of immunology (Baltimore, Md. : 1950)
Castriconi R,Daga A,Dondero A,Zona G,Poliani PL,Melotti A,Griffero F,Marubbi D,Spaziante R,Bellora F,Moretta L,Moretta A,Corte G,Bottino C
Sun Mar 15 00:00:00 EDT 2009
High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
American journal of physiology. Cell physiology
Mohan S,Konopinski R,Yan B,Centonze VE,Natarajan M
Thu Jan 01 00:00:00 EST 2009
Neural stem cell- and Schwann cell-loaded biodegradable polymer scaffolds support axonal regeneration in the transected spinal cord.
Tissue engineering. Part A
Olson HE,Rooney GE,Gross L,Nesbitt JJ,Galvin KE,Knight A,Chen B,Yaszemski MJ,Windebank AJ
Wed Jul 01 00:00:00 EDT 2009
Angiogenic capacity of human adipose-derived stromal cells during adipogenic differentiation: an in vitro study.
Tissue engineering. Part A
Verseijden F,Jahr H,Posthumus-van Sluijs SJ,Ten Hagen TL,Hovius SE,Seynhaeve AL,van Neck JW,van Osch GJ,Hofer SO
Sun Feb 01 00:00:00 EST 2009
Evidence for in vivo growth potential and vascular remodeling of tissue-engineered artery.
Tissue engineering. Part A
Cho SW,Kim IK,Kang JM,Song KW,Kim HS,Park CH,Yoo KJ,Kim BS
Wed Apr 01 00:00:00 EDT 2009
111In-labeled immunoconjugates (ICs) bispecific for the epidermal growth factor receptor (EGFR) and cyclin-dependent kinase inhibitor, p27Kip1.
Cancer biotherapy & radiopharmaceuticals
Cornelissen B,Kersemans V,McLarty K,Tran L,Reilly RM
Wed Apr 01 00:00:00 EDT 2009
Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation.
The Journal of biological chemistry
Zhou X,Agazie YM
Fri May 01 00:00:00 EDT 2009
Ligand-specific sequential regulation of transcription factors for differentiation of MCF-7 cells.
BMC genomics
Saeki Y,Endo T,Ide K,Nagashima T,Yumoto N,Toyoda T,Suzuki H,Hayashizaki Y,Sakaki Y,Okada-Hatakeyama M
Fri Nov 20 00:00:00 EST 2009
Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas.
The Journal of biological chemistry
Sim H,Hu B,Viapiano MS
Fri Sep 25 00:00:00 EDT 2009
Shift from apoptotic to necrotic cell death during human papillomavirus-induced transformation of keratinocytes.
The Journal of biological chemistry
Kravchenko-Balasha N,Mizrachy-Schwartz S,Klein S,Levitzki A
Fri Apr 24 00:00:00 EDT 2009
Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination.
The Journal of biological chemistry
Wang PS,Wang J,Xiao ZC,Pallen CJ
Fri Nov 27 00:00:00 EST 2009
Two factor reprogramming of human neural stem cells into pluripotency.
PloS one
Hester ME,Song S,Miranda CJ,Eagle A,Schwartz PH,Kaspar BK
Fri Sep 18 00:00:00 EDT 2009
Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.
The Journal of biological chemistry
Fischer A,Baljuls A,Reinders J,Nekhoroshkova E,Sibilski C,Metz R,Albert S,Rajalingam K,Hekman M,Rapp UR
Fri Jan 30 00:00:00 EST 2009
ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells.
The Journal of biological chemistry
Obara Y,Yamauchi A,Takehara S,Nemoto W,Takahashi M,Stork PJ,Nakahata N
Fri Aug 28 00:00:00 EDT 2009
HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells.
BMC cell biology
Zhang Y,Opresko L,Shankaran H,Chrisler WB,Wiley HS,Resat H
Sat Oct 31 00:00:00 EDT 2009
Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors.
The Journal of biological chemistry
Griffero F,Daga A,Marubbi D,Capra MC,Melotti A,Pattarozzi A,Gatti M,Bajetto A,Porcile C,Barbieri F,Favoni RE,Lo Casto M,Zona G,Spaziante R,Florio T,Corte G
Fri Mar 13 00:00:00 EDT 2009
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor.
Molecular systems biology
Shankaran H,Ippolito DL,Chrisler WB,Resat H,Bollinger N,Opresko LK,Wiley HS
Thu Apr 01 00:00:00 EDT 2010
Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.
Molecular systems biology
Borisov N,Aksamitiene E,Kiyatkin A,Legewie S,Berkhout J,Maiwald T,Kaimachnikov NP,Timmer J,Hoek JB,Kholodenko BN
Fri Jun 26 00:00:00 EDT 2009
Isolation and characterization of a murine resident liver stem cell.
Cell death and differentiation
Conigliaro A,Colletti M,Cicchini C,Guerra MT,Manfredini R,Zini R,Bordoni V,Siepi F,Leopizzi M,Tripodi M,Amicone L
Tue Jan 01 00:00:00 EST 2008
Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines.
Stem cells (Dayton, Ohio)
Barkho BZ,Munoz AE,Li X,Li L,Cunningham LA,Zhao X
Mon Dec 01 00:00:00 EST 2008
Generation of insulin-secreting islet-like clusters from human skin fibroblasts.
The Journal of biological chemistry
Tateishi K,He J,Taranova O,Liang G,D'Alessio AC,Zhang Y
Fri Nov 14 00:00:00 EST 2008
Micromechanical control of cell-cell interactions.
Proceedings of the National Academy of Sciences of the United States of America
Hui EE,Bhatia SN
Tue Apr 03 00:00:00 EDT 2007
The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.
Stem cells (Dayton, Ohio)
Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J
Sun Jul 01 00:00:00 EDT 2007
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.
Proceedings of the National Academy of Sciences of the United States of America
Wehrman TS,Raab WJ,Casipit CL,Doyonnas R,Pomerantz JH,Blau HM
Tue Dec 12 00:00:00 EST 2006
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.
Proceedings of the National Academy of Sciences of the United States of America
Wehrman TS,Raab WJ,Casipit CL,Doyonnas R,Pomerantz JH,Blau HM
Tue Dec 12 00:00:00 EST 2006
Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol.
Journal of immunology (Baltimore, Md. : 1950)
Øynebråten I,Barois N,Hagelsteen K,Johansen FE,Bakke O,Haraldsen G
Sat Oct 15 00:00:00 EDT 2005
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.
The Journal of biological chemistry
Sommer U,Schmid C,Sobota RM,Lehmann U,Stevenson NJ,Johnston JA,Schaper F,Heinrich PC,Haan S
Fri Sep 09 00:00:00 EDT 2005
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.
The Journal of biological chemistry
Sommer U,Schmid C,Sobota RM,Lehmann U,Stevenson NJ,Johnston JA,Schaper F,Heinrich PC,Haan S
Fri Sep 09 00:00:00 EDT 2005
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.
The Journal of biological chemistry
Sommer U,Schmid C,Sobota RM,Lehmann U,Stevenson NJ,Johnston JA,Schaper F,Heinrich PC,Haan S
Fri Sep 09 00:00:00 EDT 2005
Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Huang R,Lin Y,Shi Q,Flowers L,Ramachandran S,Horowitz IR,Parthasarathy S,Huang RP
Thu Jan 15 00:00:00 EST 2004
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 EST 2003
The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.
American journal of physiology. Cell physiology
Tsai JC,Liu L,Guan J,Aird WC
Wed Nov 01 00:00:00 EST 2000
The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.
American journal of physiology. Cell physiology
Tsai JC,Liu L,Guan J,Aird WC
Wed Nov 01 00:00:00 EST 2000
The effects of hypertonic salicylate on neutrophil migration and vascularization in the rat cornea.
Cornea
Collin HB,Hoban BP
Fri Aug 28 00:00:00 EDT 1987
Tibial plateau fractures: CT evaluation and classification.
Critical reviews in diagnostic imaging
Rafii M,Lamont JG,Firooznia H
Wed Sep 16 00:00:00 EDT 1987
