Gibco

Human FGF-10, Animal-Free Recombinant Protein, PeproTech®

Product Details

AF-100-26-25UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 7 publications 7 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species

Human

Published species

Human, Mouse

Expression System

E. coli

Amino acid sequence

MLGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV SGTKKENCPY SILEITSVEI GVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS

Molecular weight

19.3 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<0.1 EU/µg

Activity

Determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors. The expected ED50 is ≤ 0.5 ng/ml corresponding to a specific activity of ≥ 2 x 10^6 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human FGF-10 is a 19.3 kDa protein consisting of 170 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

FGF10 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This protein is also implicated to be a primary factor in the process of wound healing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CD82 is a marker to isolate β cell precursors from human iPS cells and plays a role for the maturation of β cells.

Scientific reports

Watanabe A,Tanaka A,Koga C,Matsumoto M,Okazaki Y,Kin T,Miyajima A

Wed May 05 00:00:00 EDT 2021

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease.

Scientific reports

Verstegen MMA,Roos FJM,Burka K,Gehart H,Jager M,de Wolf M,Bijvelds MJC,de Jonge HR,Ardisasmita AI,van Huizen NA,Roest HP,de Jonge J,Koch M,Pampaloni F,Fuchs SA,Schene IF,Luider TM,van der Doef HPJ,Bodewes FAJA,de Kleine RHJ,Spee B,Kremers GJ,Clevers H,IJzermans JNM,Cuppen E,van der Laan LJW

Mon Dec 14 00:00:00 EST 2020

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.

Nature communications

Calandrini C,Schutgens F,Oka R,Margaritis T,Candelli T,Mathijsen L,Ammerlaan C,van Ineveld RL,Derakhshan S,de Haan S,Dolman E,Lijnzaad P,Custers L,Begthel H,Kerstens HHD,Visser LL,Rookmaaker M,Verhaar M,Tytgat GAM,Kemmeren P,de Krijger RR,Al-Saadi R,Pritchard-Jones K,Kool M,Rios AC,van den Heuvel-Eibrink MM,Molenaar JJ,van Boxtel R,Holstege FCP,Clevers H,Drost J

Wed Mar 11 00:00:00 EDT 2020

FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior.

The Journal of cell biology

Chioni AM,Grose R

Mon Jun 11 00:00:00 EDT 2012

Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation.

PLoS pathogens

Wu X,Robotham JM,Lee E,Dalton S,Kneteman NM,Gilbert DM,Tang H

Mon Aug 20 00:00:00 EDT 2012

Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair.

PloS one

Sountoulidis A,Stavropoulos A,Giaglis S,Apostolou E,Monteiro R,Chuva de Sousa Lopes SM,Chen H,Stripp BR,Mummery C,Andreakos E,Sideras P

Wed May 15 00:00:00 EDT 2013

Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis.

PloS one

Jarosz M,Robbez-Masson L,Chioni AM,Cross B,Rosewell I,Grose R

Fri Dec 14 00:00:00 EST 2012

Polarized endocytosis of the keratinocyte growth factor receptor in migrating cells: role of SRC-signaling and cortactin.

PloS one

Belleudi F,Scrofani C,Torrisi MR,Mancini P

Mon Aug 27 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: FGF; FGF-10; Fibroblast growth factor; Fibroblast growth factor 10; Keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria

Human FGF-10, Animal-Free Recombinant Protein, PeproTech®

Product Details

AF-100-26-25UG

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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