Gibco

Human FGF-21 Recombinant Protein, PeproTech®

Product Details

100-42-25UG

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 7 publications 7 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Human, Mouse, Rat

Expression System

E. coli

Amino acid sequence

MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS

Molecular weight

19.5 kDa

Class

Recombinant

Type

Protein

Purity

≥ 90% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway.

The Journal of experimental medicine

Wu T,Liu Q,Li Y,Li H,Chen L,Yang X,Tang Q,Pu S,Kuang J,Li R,Huang Y,Zhang J,Zhang Z,Zhou J,Huang C,Zhang G,Zhao Y,Zou M,Jiang W,Mo L,He J

Mon Jun 07 00:00:00 EDT 2021

MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.

The EMBO journal

Cinque L,De Leonibus C,Iavazzo M,Krahmer N,Intartaglia D,Salierno FG,De Cegli R,Di Malta C,Svelto M,Lanzara C,Maddaluno M,Wanderlingh LG,Huebner AK,Cesana M,Bonn F,Polishchuk E,Hübner CA,Conte I,Dikic I,Mann M,Ballabio A,Sacco F,Grumati P,Settembre C

Tue Sep 01 00:00:00 EDT 2020

Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kim HY,Kwon WY,Park JB,Lee MH,Oh YJ,Suh S,Baek YH,Jeong JS,Yoo YH

Tue Sep 01 00:00:00 EDT 2020

Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes.

Scientific reports

Westphal S,Gantert T,Kless C,Hüttinger K,Klingenspor M,Fromme T

Tue Jun 11 00:00:00 EDT 2019

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics.

Molecular & cellular proteomics : MCP

Zhang HE,Hamson EJ,Koczorowska MM,Tholen S,Chowdhury S,Bailey CG,Lay AJ,Twigg SM,Lee Q,Roediger B,Biniossek ML,O'Rourke MB,McCaughan GW,Keane FM,Schilling O,Gorrell MD

Tue Jan 01 00:00:00 EST 2019

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics.

Molecular & cellular proteomics : MCP

Zhang HE,Hamson EJ,Koczorowska MM,Tholen S,Chowdhury S,Bailey CG,Lay AJ,Twigg SM,Lee Q,Roediger B,Biniossek ML,O'Rourke MB,McCaughan GW,Keane FM,Schilling O,Gorrell MD

Tue Jan 01 00:00:00 EST 2019

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood.

Nature communications

Yuan X,Tsujimoto K,Hashimoto K,Kawahori K,Hanzawa N,Hamaguchi M,Seki T,Nawa M,Ehara T,Kitamura Y,Hatada I,Konishi M,Itoh N,Nakagawa Y,Shimano H,Takai-Igarashi T,Kamei Y,Ogawa Y

Mon Feb 12 00:00:00 EST 2018

Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation.

Scientific reports

Wang Z,Leng Y,Wang J,Liao HM,Bergman J,Leeds P,Kozikowski A,Chuang DM

Thu Jan 21 00:00:00 EST 2016

Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis.

The Journal of biological chemistry

Jiang S,Yan C,Fang QC,Shao ML,Zhang YL,Liu Y,Deng YP,Shan B,Liu JQ,Li HT,Yang L,Zhou J,Dai Z,Liu Y,Jia WP

Fri Oct 24 00:00:00 EDT 2014

High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli.

BMC biotechnology

Wang H,Xiao Y,Fu L,Zhao H,Zhang Y,Wan X,Qin Y,Huang Y,Gao H,Li X

Wed Feb 17 00:00:00 EST 2010

Bioinformatics

Protein Aliases: FGF; FGF-21; FGFL; Fibroblast growth factor; Fibroblast growth factor 21; PRO10196