Gibco

Human FGF-8a Recombinant Protein, PeproTech®

Product Details

100-25A-25UG

Applications

Tested Dilution

Publications

ELISA (ELISA)

View 1 publication 1 publication

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 7 publications 7 publications

Product Specifications

Species

Human

Published species

Human

Expression System

CHO cells

Amino acid sequence

QHVREQSLVT DQLSRRLIRT YQLYSRTSGK HVQVLANKRI NAMAEDGDPF AKLIVETDTF GSRVRVRGAE TGLYICMNKK GKLIAKSNGK GKDCVFTEIV LENNYTALQN AKYEGWYMAF TRKGRPRKGS KTRQHQREVH FMKRLPRGHH TTEQSLRFEF LNYPPFTRSL RGSQRTWAPE PR

Molecular weight

21.2 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by a cell proliferation assay using balb/c 3T3 cells.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

100-00CC-500UG will be provided as 2 x 250 µg (100-00CC-250UG).

CHO cell-derived Recombinant Human FGF-8a is a 21.2 kDa protein consisting of 182 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

FGF-8 is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8a, FGF-8b, FGF-8e and FGF-8f. The human and murine FGF-8a and FGF-8b are identical, unlike human and mouse FGF-8e and FGF-8f, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model.

Neuron

Zhang K,Wang A,Zhong K,Qi S,Wei C,Shu X,Tu WY,Xu W,Xia C,Xiao Y,Chen A,Bai L,Zhang J,Luo B,Wang W,Shen C

Wed Jun 16 00:00:00 EDT 2021

Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture.

Nature communications

Nakajima T,Nakahata A,Yamada N,Yoshizawa K,Kato TM,Iwasaki M,Zhao C,Kuroki H,Ikeya M

Wed Aug 18 00:00:00 EDT 2021

Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.

Cell systems

Gerosa L,Chidley C,Fröhlich F,Sanchez G,Lim SK,Muhlich J,Chen JY,Vallabhaneni S,Baker GJ,Schapiro D,Atanasova MI,Chylek LA,Shi T,Yi L,Nicora CD,Claas A,Ng TSC,Kohler RH,Lauffenburger DA,Weissleder R,Miller MA,Qian WJ,Wiley HS,Sorger PK

100-25A was used in Enzyme-linked immunosorbent assay to show that pulsatile MAPK activation by factors in the microenvironment generates a persistent population of melanoma cells that rewires MAPK signaling to sustain non-genetic drug resistance.

Wed Nov 18 00:00:00 EST 2020

Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson's disease models.

Cell death & disease

Zhuang XX,Wang SF,Tan Y,Song JX,Zhu Z,Wang ZY,Wu MY,Cai CZ,Huang ZJ,Tan JQ,Su HX,Li M,Lu JH

Tue Feb 18 00:00:00 EST 2020

Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling.

Cell death & disease

Ke M,Chong CM,Zeng H,Huang M,Huang Z,Zhang K,Cen X,Lu JH,Yao X,Qin D,Su H

Tue Feb 18 00:00:00 EST 2020

Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder.

Translational psychiatry

Truvé K,Parris TZ,Vizlin-Hodzic D,Salmela S,Berger E,Ågren H,Funa K

Mon Nov 09 00:00:00 EST 2020

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons.

Scientific reports

Schwartzentruber A,Boschian C,Lopes FM,Myszczynska MA,New EJ,Beyrath J,Smeitink J,Ferraiuolo L,Mortiboys H

Wed Sep 23 00:00:00 EDT 2020

Generation of human brain region-specific organoids using a miniaturized spinning bioreactor.

Nature protocols

Qian X,Jacob F,Song MM,Nguyen HN,Song H,Ming GL

Thu Mar 01 00:00:00 EST 2018

Bioinformatics

Protein Aliases: ace; AIGF; Androgen-induced growth factor; cb110; etID309886.13; fb73a06; FGF-8; fgf8; Fibroblast growth factor 8; fibroblast growth factor 8 (androgen-induced); HBGF-8; Heparin-binding growth factor 8; ibd5031