Product References
Kidney organoids recapitulate human basement membrane assembly in health and disease.
eLife
Morais MRPT,Tian P,Lawless C,Murtuza-Baker S,Hopkinson L,Woods S,Mironov A,Long DA,Gale DP,Zorn TMT,Kimber SJ,Zent R,Lennon R
100-23 was used in In vitro experiments to investigate the effects of basement membranes isoforms on kidney organoids.
Tue Jan 25 00:00:00 EST 2022
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms.
Cancer cell
Hu H,Piotrowska Z,Hare PJ,Chen H,Mulvey HE,Mayfield A,Noeen S,Kattermann K,Greenberg M,Williams A,Riley AK,Wilson JJ,Mao YQ,Huang RP,Banwait MK,Ho J,Crowther GS,Hariri LP,Heist RS,Kodack DP,Pinello L,Shaw AT,Mino-Kenudson M,Hata AN,Sequist LV,Benes CH,Niederst MJ,Engelman JA
Mon Nov 08 00:00:00 EST 2021
TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models.
Frontiers in medicine
Zhou Y,Kim C,Pablo JLB,Zhang F,Jung JY,Xiao L,Bazua-Valenti S,Emani M,Hopkins CR,Weins A,Greka A
100-23 was used in In vitro experiments to reveal the relevance of TRPC5 channel inhibition in puromycin-aminonucleoside induced nephrosis models, highlighting the potential of this therapeutic strategy for patients.
Wed Jun 07 00:00:00 EDT 2023
Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway.
Nature communications
Zhang D,Huang J,Sun X,Chen H,Huang S,Yang J,Du X,Tan Q,Luo F,Zhang R,Zhou S,Jiang W,Ni Z,Wang Z,Jin M,Xu M,Li F,Chen L,Liu M,Su N,Luo X,Yin L,Zhu Y,Feng JQ,Chen D,Qi H,Chen L,Xie Y
Mon Jul 19 00:00:00 EDT 2021
The miR-199a/214 Cluster Controls Nephrogenesis and Vascularization in a Human Embryonic Stem Cell Model.
Stem cell reports
Bantounas I,Lopes FM,Rooney KM,Woolf AS,Kimber SJ
Tue Jan 12 00:00:00 EST 2021
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Cell
Monteil V,Kwon H,Prado P,Hagelkrüys A,Wimmer RA,Stahl M,Leopoldi A,Garreta E,Hurtado Del Pozo C,Prosper F,Romero JP,Wirnsberger G,Zhang H,Slutsky AS,Conder R,Montserrat N,Mirazimi A,Penninger JM
100-23 was used in Cell Culture to show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2.
Thu May 14 00:00:00 EDT 2020
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Cell
Monteil V,Kwon H,Prado P,Hagelkrüys A,Wimmer RA,Stahl M,Leopoldi A,Garreta E,Hurtado Del Pozo C,Prosper F,Romero JP,Wirnsberger G,Zhang H,Slutsky AS,Conder R,Montserrat N,Mirazimi A,Penninger JM
100-23 was used in Cell Culture to show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2.
Thu May 14 00:00:00 EDT 2020
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
The EMBO journal
Cinque L,De Leonibus C,Iavazzo M,Krahmer N,Intartaglia D,Salierno FG,De Cegli R,Di Malta C,Svelto M,Lanzara C,Maddaluno M,Wanderlingh LG,Huebner AK,Cesana M,Bonn F,Polishchuk E,Hübner CA,Conte I,Dikic I,Mann M,Ballabio A,Sacco F,Grumati P,Settembre C
Tue Sep 01 00:00:00 EDT 2020
FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching.
Science signaling
Yin Y,Ornitz DM
100-23 was used in Cell Culture to investigate the effects of fibroblast growth factors 9 and 10 on direct lung epithelial specification and branching.
Tue Mar 03 00:00:00 EST 2020
FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching.
Science signaling
Yin Y,Ornitz DM
100-23 was used in Cell Culture to investigate the effects of fibroblast growth factors 9 and 10 on direct lung epithelial specification and branching.
Tue Mar 03 00:00:00 EST 2020
Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li J,Li X,Song J,Yan B,Rock SA,Jia J,Liu J,Wang C,Weiss T,Weiss HL,Gao T,Alam A,Evers BM
Mon Jun 01 00:00:00 EDT 2020
Aberrant Differentiation of Human Pluripotent Stem Cell-Derived Kidney Precursor Cells inside Mouse Vascularized Bioreactors.
Nephron
Ranjzad P,Jinks J,Salahi AP,Bantounas I,Derby B,Kimber SJ,Woolf AS,Wong JKF
100-23 was used in Cell Culture to investigate human pluripotent stem cell derived kidney precursor cells in kidney treatment.
Mon Oct 18 00:00:00 EDT 2021
Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.
Cell
Dvela-Levitt M,Kost-Alimova M,Emani M,Kohnert E,Thompson R,Sidhom EH,Rivadeneira A,Sahakian N,Roignot J,Papagregoriou G,Montesinos MS,Clark AR,McKinney D,Gutierrez J,Roth M,Ronco L,Elonga E,Carter TA,Gnirke A,Melanson M,Hartland K,Wieder N,Hsu JC,Deltas C,Hughey R,Bleyer AJ,Kmoch S,Živná M,Barešova V,Kota S,Schlondorff J,Heiman M,Alper SL,Wagner F,Weins A,Golub TR,Lander ES,Greka A
Thu Jul 25 00:00:00 EDT 2019
Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in the Subretinal Space of the Cat Eye.
Stem cells and development
Singh RK,Occelli LM,Binette F,Petersen-Jones SM,Nasonkin IO
Sun Sep 01 00:00:00 EDT 2019
Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.
Cell stem cell
Low JH,Li P,Chew EGY,Zhou B,Suzuki K,Zhang T,Lian MM,Liu M,Aizawa E,Rodriguez Esteban C,Yong KSM,Chen Q,Campistol JM,Fang M,Khor CC,Foo JN,Izpisua Belmonte JC,Xia Y
100-23 was used in In vitro experiments to establish a versatile protocol generating vascularized 3D kidney organoids from hPSCs with controlled nephronal segmentation, employed subsequently to develop an in vitro ARPKD model.
Thu Sep 05 00:00:00 EDT 2019
Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation.
Nature communications
Subramanian A,Sidhom EH,Emani M,Vernon K,Sahakian N,Zhou Y,Kost-Alimova M,Slyper M,Waldman J,Dionne D,Nguyen LT,Weins A,Marshall JL,Rosenblatt-Rosen O,Regev A,Greka A
Fri Nov 29 00:00:00 EST 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 EDT 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 EDT 2019
A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia.
Science signaling
Xiao Z,Riccardi D,Velazquez HA,Chin AL,Yates CR,Carrick JD,Smith JC,Baudry J,Quarles LD
Tue Nov 22 00:00:00 EST 2016
Multiple roles of extracellular fibroblast growth factors in lung cancer cells.
International journal of oncology
Suzuki T,Yasuda H,Funaishi K,Arai D,Ishioka K,Ohgino K,Tani T,Hamamoto J,Ohashi A,Naoki K,Betsuyaku T,Soejima K
Thu Jan 01 00:00:00 EST 2015
Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior.
Stem cell research
Hegab AE,Arai D,Gao J,Kuroda A,Yasuda H,Ishii M,Naoki K,Soejima K,Betsuyaku T
Wed Jul 01 00:00:00 EDT 2015
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 EDT 2013
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.
The Journal of cell biology
Ahmed Z,Lin CC,Suen KM,Melo FA,Levitt JA,Suhling K,Ladbury JE
Mon Feb 18 00:00:00 EST 2013
Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development.
Tissue engineering. Part A
Hellingman CA,Koevoet W,Kops N,Farrell E,Jahr H,Liu W,Baatenburg de Jong RJ,Frenz DA,van Osch GJ
Mon Feb 01 00:00:00 EST 2010
Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis.
Endocrinology
Chi L,Itäranta P,Zhang S,Vainio S
Tue Aug 01 00:00:00 EDT 2006
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
The Journal of biological chemistry
Zhang X,Ibrahimi OA,Olsen SK,Umemori H,Mohammadi M,Ornitz DM
Fri Jun 09 00:00:00 EDT 2006
Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans.
The Journal of biological chemistry
McDowell LM,Frazier BA,Studelska DR,Giljum K,Chen J,Liu J,Yu K,Ornitz DM,Zhang L
Fri Mar 17 00:00:00 EST 2006
ERM is required for transcriptional control of the spermatogonial stem cell niche.
Nature
Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM
Thu Aug 18 00:00:00 EDT 2005
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.
Developmental cell
Lavine KJ,Yu K,White AC,Zhang X,Smith C,Partanen J,Ornitz DM
Sat Jan 01 00:00:00 EST 2005
Fibroblast growth factor 9 secretion is mediated by a non-cleaved amino-terminal signal sequence.
The Journal of biological chemistry
Revest JM,DeMoerlooze L,Dickson C
Fri Mar 17 00:00:00 EST 2000
