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Product Details
100-66-25UG
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
MKKKVKNGLH SKVVSEQKDT LGNTQIKQKS RPGNKGKFVT KDQANCRWAA TEQEEGISLK VECTQLDHEF SCVFAGNPTS CLKLKDERVY WKQVARNLRS QKDICRYSKT AVKTRVCRKD FPESSLKLVS STLFGNTKPR KEKTEMSPRE HIKGKETTPS SLAVTQTMAT KAPECVEDPD MANQRKTALE FCGETWSSLC TFFLSIVQDT SC
Molecular weight
23.9 kDa
Class
Recombinant
Type
Protein
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors. The expected ED50 for this effect is 1.5-3.0 ug/ml.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Human FGF-BP-1 expressed in E.coli is a 24.0 kDa protein containing 212 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
FGFBP1 encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17 kDa HBGF-binding protein; 17 kDa heparin-binding growth factor-binding protein; FGF-binding protein 1; FGF-BP; Fibroblast growth factor-binding protein 1; heparin-binding growth factor binding protein
Gene Aliases: FGF-BP; FGF-BP1; FGFBP; FGFBP-1; FGFBP1; HBP17
UniProt ID: (Human) Q14512
Entrez Gene ID: (Human) 9982
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