Product References
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms.
Cancer cell
Hu H,Piotrowska Z,Hare PJ,Chen H,Mulvey HE,Mayfield A,Noeen S,Kattermann K,Greenberg M,Williams A,Riley AK,Wilson JJ,Mao YQ,Huang RP,Banwait MK,Ho J,Crowther GS,Hariri LP,Heist RS,Kodack DP,Pinello L,Shaw AT,Mino-Kenudson M,Hata AN,Sequist LV,Benes CH,Niederst MJ,Engelman JA
Mon Nov 08 00:00:00 EST 2021
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
Thu Jun 03 00:00:00 EDT 2021
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
Thu Jun 03 00:00:00 EDT 2021
A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells.
Communications biology
Futrega K,Robey PG,Klein TJ,Crawford RW,Doran MR
Mon Jan 04 00:00:00 EST 2021
Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.
Cell reports
Yu K,Hammerschmidt SI,Permanyer M,Galla M,Rothe M,Zheng X,Werth K,Martens R,Lueder Y,Janssen A,Friedrichsen M,Bernhardt G,Förster R
Tue Jun 22 00:00:00 EDT 2021
Protocol for automated production of human stem cell derived liver spheres.
STAR protocols
Meseguer-Ripolles J,Kasarinaite A,Lucendo-Villarin B,Hay DC
Fri Jun 18 00:00:00 EDT 2021
Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids.
Nature
van den Brink SC,Alemany A,van Batenburg V,Moris N,Blotenburg M,Vivié J,Baillie-Johnson P,Nichols J,Sonnen KF,Martinez Arias A,van Oudenaarden A
100-17A was used in In vitro experiments to study expression patterns of genes in gastruloids by comparing mouse gastruloids with mouse embryos using single-cell RNA sequencing and spatial transcriptomics.
Mon Jun 01 00:00:00 EDT 2020
Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.
Journal of cellular and molecular medicine
Meyer M,Ben-Yehuda Greenwald M,Rauschendorfer T,Sänger C,Jukic M,Iizuka H,Kubo F,Chen L,Ornitz DM,Werner S
Wed Jan 01 00:00:00 EST 2020
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
Nature communications
Wang C,Li Y,Yan S,Wang H,Shao X,Xiao M,Yang B,Qin G,Kong R,Chen R,Zhang N
Mon Jun 22 00:00:00 EDT 2020
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.
Proceedings of the National Academy of Sciences of the United States of America
Boonekamp KE,Kretzschmar K,Wiener DJ,Asra P,Derakhshan S,Puschhof J,López-Iglesias C,Peters PJ,Basak O,Clevers H
Tue Jul 16 00:00:00 EDT 2019
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.
Nature communications
Kusakabe M,Sun AC,Tyshchenko K,Wong R,Nanda A,Shanna C,Gusscott S,Chavez EA,Lorzadeh A,Zhu A,Hill A,Hung S,Brown S,Babaian A,Wang X,Holt RA,Steidl C,Karsan A,Humphries RK,Eaves CJ,Hirst M,Weng AP
Tue Jul 02 00:00:00 EDT 2019
A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment.
Scientific reports
Kang J,Choi YJ,Seo BY,Jo U,Park SI,Kim YH,Park KH
Wed Jun 19 00:00:00 EDT 2019
Sprouty2 suppresses progression and correlates to favourable prognosis of intrahepatic cholangiocarcinoma via antagonizing FGFR2 signalling.
Journal of cellular and molecular medicine
Xu YF,Liu HD,Liu ZL,Pan C,Yang XQ,Ning SL,Zhang ZL,Guo S,Yu JM
Thu Nov 01 00:00:00 EDT 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
100-17A was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
PloS one
Sambathkumar R,Akkerman R,Dastidar S,Roelandt P,Kumar M,Bajaj M,Mestre Rosa AR,Helsen N,Vanslembrouck V,Kalo E,Khurana S,Laureys J,Gysemans C,Faas MM,de Vos P,Verfaillie CM
100-17A was used in Cell Culture to investigate 14 transcription factors in multipotent adult progenitor cell reprogramming for hepatocyte and endocrine pacreatic-like cell culture.
Tue Jul 31 00:00:00 EDT 2018
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.
Cell stem cell
Fujii M,Matano M,Toshimitsu K,Takano A,Mikami Y,Nishikori S,Sugimoto S,Sato T
100-17A was used in In vitro experiments to investigate maintenance of intestinal organoid culture with reflective cellular diversity.
Thu Dec 06 00:00:00 EST 2018
iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
Cell death & disease
Melguizo-Sanchis D,Xu Y,Taheem D,Yu M,Tilgner K,Barta T,Gassner K,Anyfantis G,Wan T,Elango R,Alharthi S,El-Harouni AA,Przyborski S,Adam S,Saretzki G,Samarasinghe S,Armstrong L,Lako M
Fri Jan 26 00:00:00 EST 2018
Dual Therapeutic Action of a Neutralizing Anti-FGF2 Aptamer in Bone Disease and Bone Cancer Pain.
Molecular therapy : the journal of the American Society of Gene Therapy
Jin L,Nonaka Y,Miyakawa S,Fujiwara M,Nakamura Y
Tue Nov 01 00:00:00 EDT 2016
A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia.
Science signaling
Xiao Z,Riccardi D,Velazquez HA,Chin AL,Yates CR,Carrick JD,Smith JC,Baudry J,Quarles LD
Tue Nov 22 00:00:00 EST 2016
Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.
Scientific reports
Yamada K,Miyamoto Y,Tsujii A,Moriyama T,Ikuno Y,Shiromizu T,Serada S,Fujimoto M,Tomonaga T,Naka T,Yoneda Y,Oka M
Thu Feb 18 00:00:00 EST 2016
H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro.
Stem cell reports
Vanhove J,Pistoni M,Welters M,Eggermont K,Vanslembrouck V,Helsen N,Boon R,Najimi M,Sokal E,Collas P,Voncken JW,Verfaillie CM
Tue Aug 09 00:00:00 EDT 2016
Direct bone marrow HSC transplantation enhances local engraftment at the expense of systemic engraftment in NSG mice.
Scientific reports
Futrega K,Lott WB,Doran MR
Mon Apr 11 00:00:00 EDT 2016
Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus.
Proceedings of the National Academy of Sciences of the United States of America
Brugman MH,Wiekmeijer AS,van Eggermond M,Wolvers-Tettero I,Langerak AW,de Haas EF,Bystrykh LV,van Rood JJ,de Haan G,Fibbe WE,Staal FJ
Tue Nov 03 00:00:00 EST 2015
FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7.
Cancer science
Bai YP,Shang K,Chen H,Ding F,Wang Z,Liang C,Xu Y,Sun MH,Li YY
Thu Oct 01 00:00:00 EDT 2015
PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells.
Scientific reports
Varagnolo L,Lin Q,Obier N,Plass C,Dietl J,Zenke M,Claus R,Müller AM
Wed Jul 22 00:00:00 EDT 2015
Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.
Molecular therapy. Methods & clinical development
Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW
100-17A was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.
Mon Jun 08 00:00:00 EDT 2015
Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line.
Scientific reports
Sluch VM,Davis CH,Ranganathan V,Kerr JM,Krick K,Martin R,Berlinicke CA,Marsh-Armstrong N,Diamond JS,Mao HQ,Zack DJ
Fri Nov 13 00:00:00 EST 2015
Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model.
Molecular therapy. Nucleic acids
Haemmerle R,Phaltane R,Rothe M,Schröder S,Schambach A,Moritz T,Modlich U
Tue Oct 07 00:00:00 EDT 2014
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 EDT 2013
Hematopoietic stem and progenitor cells acquire distinct DNA-hypermethylation during in vitro culture.
Scientific reports
Weidner CI,Walenda T,Lin Q,Wölfler MM,Denecke B,Costa IG,Zenke M,Wagner W
Thu Nov 28 00:00:00 EST 2013
Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia.
PloS one
Wu AL,Feng B,Chen MZ,Kolumam G,Zavala-Solorio J,Wyatt SK,Gandham VD,Carano RA,Sonoda J
Fri Sep 27 00:00:00 EDT 2013
Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.
Blood
Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F
Thu May 03 00:00:00 EDT 2012
Two preferentially expressed proteins protect vascular endothelial cells from an attack by peptide-specific CTL.
Journal of immunology (Baltimore, Md. : 1950)
Thommen DS,Schuster H,Keller M,Kapoor S,Weinzierl AO,Chennakesava CS,Wang X,Rohrer L,von Eckardstein A,Stevanovic S,Biedermann BC
Fri Jun 01 00:00:00 EDT 2012
TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms.
PloS one
Takaesu G,Inagaki M,Takubo K,Mishina Y,Hess PR,Dean GA,Yoshimura A,Matsumoto K,Suda T,Ninomiya-Tsuji J
Tue May 28 00:00:00 EDT 2013
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
Blood
Maetzig T,Brugman MH,Bartels S,Heinz N,Kustikova OS,Modlich U,Li Z,Galla M,Schiedlmeier B,Schambach A,Baum C
Thu Mar 17 00:00:00 EDT 2011
HuR controls lung branching morphogenesis and mesenchymal FGF networks.
Developmental biology
Sgantzis N,Yiakouvaki A,Remboutsika E,Kontoyiannis DL
Wed Jun 15 00:00:00 EDT 2011
Fibroblast growth factor 2-antagonist activity of a long-pentraxin 3-derived anti-angiogenic pentapeptide.
Journal of cellular and molecular medicine
Leali D,Bianchi R,Bugatti A,Nicoli S,Mitola S,Ragona L,Tomaselli S,Gallo G,Catello S,Rivieccio V,Zetta L,Presta M
Sun Aug 01 00:00:00 EDT 2010
IL-32-dependent effects of IL-1beta on endothelial cell functions.
Proceedings of the National Academy of Sciences of the United States of America
Nold-Petry CA,Nold MF,Zepp JA,Kim SH,Voelkel NF,Dinarello CA
Tue Mar 10 00:00:00 EDT 2009
VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown.
Proceedings of the National Academy of Sciences of the United States of America
Argaw AT,Gurfein BT,Zhang Y,Zameer A,John GR
Tue Feb 10 00:00:00 EST 2009
Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways.
The Journal of biological chemistry
Li F,Shetty AK,Sugahara K
Fri Feb 02 00:00:00 EST 2007
Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine.
Annals of the New York Academy of Sciences
Cass WA,Peters LE,Harned ME,Seroogy KB
Tue Aug 01 00:00:00 EDT 2006
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
The Journal of biological chemistry
Zhang X,Ibrahimi OA,Olsen SK,Umemori H,Mohammadi M,Ornitz DM
Fri Jun 09 00:00:00 EDT 2006
ERM is required for transcriptional control of the spermatogonial stem cell niche.
Nature
Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM
Thu Aug 18 00:00:00 EDT 2005
Novel 70-kDa chondroitin sulfate/dermatan sulfate hybrid chains with a unique heterogeneous sulfation pattern from shark skin, which exhibit neuritogenic activity and binding activities for growth factors and neurotrophic factors.
The Journal of biological chemistry
Nandini CD,Itoh N,Sugahara K
Fri Feb 11 00:00:00 EST 2005
Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.
Blood
Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M
Thu Jul 01 00:00:00 EDT 2004
Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.
Blood
Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M
Thu Jul 01 00:00:00 EDT 2004
Chondroitin sulfate/dermatan sulfate hybrid chains from embryonic pig brain, which contain a higher proportion of L-iduronic acid than those from adult pig brain, exhibit neuritogenic and growth factor binding activities.
The Journal of biological chemistry
Bao X,Nishimura S,Mikami T,Yamada S,Itoh N,Sugahara K
Fri Mar 12 00:00:00 EST 2004
Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish. Neuritogenic and binding activities for growth factors and neurotrophic factors.
The Journal of biological chemistry
Nandini CD,Mikami T,Ohta M,Itoh N,Akiyama-Nambu F,Sugahara K
Fri Dec 03 00:00:00 EST 2004
Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues.
The Journal of biological chemistry
Deepa SS,Umehara Y,Higashiyama S,Itoh N,Sugahara K
Fri Nov 15 00:00:00 EST 2002
Heparin/Heparan sulfate domains in binding and signaling of fibroblast growth factor 8b.
The Journal of biological chemistry
Loo BM,Salmivirta M
Fri Sep 06 00:00:00 EDT 2002
Induction of bud formation of embryonic mouse tracheal epithelium by fibroblast growth factor plus transferrin in mesenchyme-free culture.
Developmental dynamics : an official publication of the American Association of Anatomists
Ohtsuka N,Urase K,Momoi T,Nogawa H
Mon Oct 01 00:00:00 EDT 2001
The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.
American journal of physiology. Cell physiology
Tsai JC,Liu L,Guan J,Aird WC
Wed Nov 01 00:00:00 EST 2000
The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.
American journal of physiology. Cell physiology
Tsai JC,Liu L,Guan J,Aird WC
Wed Nov 01 00:00:00 EST 2000
