Product References
Isolation and Functional Analysis of Myoepithelial Cells from Adult Mouse Submandibular Glands.
Methods in molecular biology (Clifton, N.J.)
Yasuhara R,Kang S,Tokumasu R,Mishima K
AF-100-18B was used in Cell Culture to describe detailed methods and tips for the isolation and functional analysis of myoepithelial cells.
Wed Nov 08 00:00:00 EST 2023
Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1.
Molecular psychiatry
Schäffner I,Wittmann MT,Vogel T,Lie DC
AF-100-18B was used in Cell Culture to reveal differential vulnerability of neuronal subtypes to increased FOXG1 dosage and suggest that activity of a FOXG1/NR4A1 axis contributes to such subtype-specific response.
Sun Jan 01 00:00:00 EST 2023
Reduced Cell-ECM Interactions in the EpiSC Colony Center Cause Heterogeneous Differentiation.
Cells
Amar K,Saha S,Debnath A,Weng CH,Roy A,Han KY,Chowdhury F
AF-100-18B was used in Cell Culture to demonstrate a biophysical regulation of heterogeneous EpiSC colony differentiation.
Sun Jan 15 00:00:00 EST 2023
Spatially controlled construction of assembloids using bioprinting.
Nature communications
Roth JG,Brunel LG,Huang MS,Liu Y,Cai B,Sinha S,Yang F,Pașca SP,Shin S,Heilshorn SC
AF-100-18B was used in Cell Culture to demonstrate the potential for the SPOT platform to construct assembloids which recapitulate key developmental processes and disease etiologies.
Wed Jul 19 00:00:00 EDT 2023
Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer.
Cancer immunology research
Gil Del Alcazar CR,Trinh A,Alečković M,Rojas Jimenez E,Harper NW,Oliphant MUJ,Xie S,Krop ED,Lulseged B,Murphy KC,Keenan TE,Van Allen EM,Tolaney SM,Freeman GJ,Dillon DA,Muthuswamy SK,Polyak K
AF-100-18B was used in Tissue/organ culture to address how there are no good murine models of estrogen receptor-positive (ER+) breast cancer and demonstrate that Nitroso-N-methylurea-induced mammary tumors in outbred Sprague-Dawley rats recapitulate the heterogeneity for mutational profiles, ER expression, and immune evasive mechanisms observed in human breast cancer.
Fri Jun 03 00:00:00 EDT 2022
A Cd9+Cd271+ stem/progenitor population and the SHP2 pathway contribute to neonatal-to-adult switching that regulates tendon maturation.
Cell reports
Fan C,Zhao Y,Chen Y,Qin T,Lin J,Han S,Yan R,Lei T,Xie Y,Wang T,Gu S,Ouyang H,Shen W,Yin Z,Chen X
AF-100-18B was used in Cell Culture to integrate the structural, mechanical, and molecular properties of tendon maturation to show that post-natal days 7-14 are the crucial transitional stage for mouse tendon maturation.
Tue Apr 26 00:00:00 EDT 2022
Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress.
Cell death & disease
Al Haq AT,Tseng HY,Chen LM,Wang CC,Hsu HL
AF-100-18B was used in Sample Preparation (FC/FACS) to reveal a novel stratagem for triple-negative breast cancer (TNBC) management involving targeting the MCT-1 oncogene-induced mitochondrial prooxidant MnSOD pathway, which prevents the development of an immunosuppressive tumor microenvironment.
Tue Jan 11 00:00:00 EST 2022
GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence.
Scientific reports
Uceda-Castro R,van Asperen JV,Vennin C,Sluijs JA,van Bodegraven EJ,Margarido AS,Robe PAJ,van Rheenen J,Hol EM
AF-100-18B was used in Tissue/organ culture to study an ex vivo brain slice invasion model to regulate tumour dynamics of glioma cells.
Mon Jan 10 00:00:00 EST 2022
MicroRNA-582-5p Contributes to the Maintenance of Neural Stem Cells Through Inhibiting Secretory Protein FAM19A1.
Frontiers in cellular neuroscience
Zhang YF,Li XX,Cao XL,Ji CC,Gao XY,Gao D,Han H,Yu F,Zheng MH
AF-100-18B was used in Cell Culture to study the function and mechanism of miR-582-5p in the maintenance of neural stem cells (NSCs) in vitro and in vivo to uncover a new epigenetic mechanism that regulates the maintenance of NSCs, therefore providing novel targets to amplify NSCs in vitro and to promote neurogenesis in vivo during brain pathology and aging.
Sat Jul 16 00:00:00 EDT 2022
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling.
Cell research
Zhang XN,Yang KD,Chen C,He ZC,Wang QH,Feng H,Lv SQ,Wang Y,Mao M,Liu Q,Tan YY,Wang WY,Li TR,Che LR,Qin ZY,Wu LX,Luo M,Luo CH,Liu YQ,Yin W,Wang C,Guo HT,Li QR,Wang B,Chen W,Wang S,Shi Y,Bian XW,Ping YF
AF-100-18B was used in Cell Culture to reveal the role of pericytes as an extrinsic stimulator potentiating DDR signaling in GBM cells.
Fri Oct 01 00:00:00 EDT 2021
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling.
Cell research
Zhang XN,Yang KD,Chen C,He ZC,Wang QH,Feng H,Lv SQ,Wang Y,Mao M,Liu Q,Tan YY,Wang WY,Li TR,Che LR,Qin ZY,Wu LX,Luo M,Luo CH,Liu YQ,Yin W,Wang C,Guo HT,Li QR,Wang B,Chen W,Wang S,Shi Y,Bian XW,Ping YF
AF-100-18B was used in Cell Culture to reveal the role of pericytes as an extrinsic stimulator potentiating DDR signaling in GBM cells.
Fri Oct 01 00:00:00 EDT 2021
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Cancer cell
Hara T,Chanoch-Myers R,Mathewson ND,Myskiw C,Atta L,Bussema L,Eichhorn SW,Greenwald AC,Kinker GS,Rodman C,Gonzalez Castro LN,Wakimoto H,Rozenblatt-Rosen O,Zhuang X,Fan J,Hunter T,Verma IM,Wucherpfennig KW,Regev A,Suvà ML,Tirosh I
Mon Jun 14 00:00:00 EDT 2021
Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy.
Advanced functional materials
Karlsson J,Tzeng SY,Hemmati S,Luly KM,Choi O,Rui Y,Wilson DR,Kozielski KL,Quiñones-Hinojosa A,Green JJ
Thu Apr 22 00:00:00 EDT 2021
Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder.
Molecular psychiatry
Griesi-Oliveira K,Fogo MS,Pinto BGG,Alves AY,Suzuki AM,Morales AG,Ezquina S,Sosa OJ,Sutton GJ,Sunaga-Franze DY,Bueno AP,Seabra G,Sardinha L,Costa SS,Rosenberg C,Zachi EC,Sertie AL,Martins-de-Souza D,Reis EM,Voineagu I,Passos-Bueno MR
Sat May 01 00:00:00 EDT 2021
Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway.
Journal of natural medicines
Mao X,Zhang X,Zheng X,Chen Y,Xuan Z,Huang P
AF-100-18B was used in Cell Culture to study the effect and mechanism of curcumin in stem cell marker LGR5(+) colorectal cancer stem cells (CSCs).
Tue Jun 01 00:00:00 EDT 2021
The white matter is a pro-differentiative niche for glioblastoma.
Nature communications
Brooks LJ,Clements MP,Burden JJ,Kocher D,Richards L,Devesa SC,Zakka L,Woodberry M,Ellis M,Jaunmuktane Z,Brandner S,Morrison G,Pollard SM,Dirks PB,Marguerat S,Parrinello S
Mon Apr 12 00:00:00 EDT 2021
An exercise "sweet spot" reverses cognitive deficits of aging by growth-hormone-induced neurogenesis.
iScience
Blackmore DG,Steyn FJ,Carlisle A,O'Keeffe I,Vien KY,Zhou X,Leiter O,Jhaveri D,Vukovic J,Waters MJ,Bartlett PF
Fri Nov 19 00:00:00 EST 2021
Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.
Cell death and differentiation
Manic G,Musella M,Corradi F,Sistigu A,Vitale S,Soliman Abdel Rehim S,Mattiello L,Malacaria E,Galassi C,Signore M,Pallocca M,Scalera S,Goeman F,De Nicola F,Guarracino A,Pennisi R,Antonangeli F,Sperati F,Baiocchi M,Biffoni M,Fanciulli M,Maugeri-Saccà M,Franchitto A,Pichierri P,De Maria R,Vitale I
Thu Jul 01 00:00:00 EDT 2021
Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation.
The Journal of biological chemistry
Krantz S,Kim YM,Srivastava S,Leasure JW,Toth PT,Marsboom G,Rehman J
Wed Dec 01 00:00:00 EST 2021
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression.
Nature communications
Liu J,Ottaviani D,Sefta M,Desbrousses C,Chapeaublanc E,Aschero R,Sirab N,Lubieniecki F,Lamas G,Tonon L,Dehainault C,Hua C,Fréneaux P,Reichman S,Karboul N,Biton A,Mirabal-Ortega L,Larcher M,Brulard C,Arrufat S,Nicolas A,Elarouci N,Popova T,Némati F,Decaudin D,Gentien D,Baulande S,Mariani O,Dufour F,Guibert S,Vallot C,Rouic LL,Matet A,Desjardins L,Pascual-Pasto G,Suñol M,Catala-Mora J,Llano GC,Couturier J,Barillot E,Schaiquevich P,Gauthier-Villars M,Stoppa-Lyonnet D,Golmard L,Houdayer C,Brisse H,Bernard-Pierrot I,Letouzé E,Viari A,Saule S,Sastre-Garau X,Doz F,Carcaboso AM,Cassoux N,Pouponnot C,Goureau O,Chantada G,de Reyniès A,Aerts I,Radvanyi F
Wed Sep 22 00:00:00 EDT 2021
Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation.
Communications biology
Kim J,Moon Y
Mon May 10 00:00:00 EDT 2021
Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist.
Cell death & disease
Boccellato C,Kolbe E,Peters N,Juric V,Fullstone G,Verreault M,Idbaih A,Lamfers MLM,Murphy BM,Rehm M
Thu Jun 24 00:00:00 EDT 2021
Generation of Neurosphere-Derived Organoid-Like-Aggregates (NEDAS) from Neural Stem Cells.
Current protocols
Watanabe F,Schoeffler A,Fair SR,Hester ME,Fedorko J,Imitola J
Mon Feb 01 00:00:00 EST 2021
CREB signaling activity correlates with differentiation and survival in medulloblastoma.
Scientific reports
Armandari I,Zomerman WW,Plasschaert SLA,Smit MJ,Martini TEI,de Camargo Magalhães ES,Hogeling SM,Rozema-Huizinga GC,Lourens HJ,Meeuwsen-de Boer TGJ,Scherpen FJG,de Bont ESJM,Bruggeman SWM
Mon Aug 09 00:00:00 EDT 2021
Directed Differentiation of Human Pluripotent Stem Cells toward Skeletal Myogenic Progenitors and Their Purification Using Surface Markers.
Cells
Xu N,Wu J,Ortiz-Vitali JL,Li Y,Darabi R
AF-100-18B was used in In vitro experiments to develop an improved directed differentiation method for the derivation of skeletal myogenic progenitors from Human Pluripotent Stem Cells.
Thu Oct 14 00:00:00 EDT 2021
Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma.
Scientific reports
Schwinn S,Mokhtari Z,Thusek S,Schneider T,Sirén AL,Tiemeyer N,Caruana I,Miele E,Schlegel PG,Beilhack A,Wölfl M
Wed Jul 07 00:00:00 EDT 2021
Deregulation of protein phosphatase 2A inhibitor SET is associated with malignant progression in breast cancer.
Scientific reports
Tozuka K,Wongsirisin P,Nagai SE,Kobayashi Y,Kanno M,Kubo K,Takai K,Inoue K,Matsumoto H,Shimizu Y,Suganuma M
Fri Jul 09 00:00:00 EDT 2021
GD2 CAR T cells against human glioblastoma.
NPJ precision oncology
Prapa M,Chiavelli C,Golinelli G,Grisendi G,Bestagno M,Di Tinco R,Dall'Ora M,Neri G,Candini O,Spano C,Petrachi T,Bertoni L,Carnevale G,Pugliese G,Depenni R,Feletti A,Iaccarino C,Pavesi G,Dominici M
AF-100-18B was used in Cell Culture to conclude that the proposed anti-GD2 CAR can counteract human glioblastoma potentially opening a new therapeutic option for a still incurable cancer.
Wed Oct 27 00:00:00 EDT 2021
Augmented Therapeutic Potential of Glutaminase Inhibitor CB839 in Glioblastoma Stem Cells Using Gold Nanoparticle Delivery.
Pharmaceutics
Giesen B,Nickel AC,Barthel J,Kahlert UD,Janiak C
AF-100-18B was used in Cell Culture to study combining CB839 with Au nanotechnology.
Tue Feb 23 00:00:00 EST 2021
OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.
Nature communications
Ames J,Yadavalli T,Suryawanshi R,Hopkins J,Agelidis A,Patil C,Fredericks B,Tseng H,Valyi-Nagy T,Shukla D
Mon Sep 13 00:00:00 EDT 2021
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia.
Translational psychiatry
Szabo A,Akkouh IA,Vandenberghe M,Osete JR,Hughes T,Heine V,Smeland OB,Glover JC,Andreassen OA,Djurovic S
Fri Oct 29 00:00:00 EDT 2021
A non-invasive method to generate induced pluripotent stem cells from primate urine.
Scientific reports
Geuder J,Wange LE,Janjic A,Radmer J,Janssen P,Bagnoli JW,Müller S,Kaul A,Ohnuki M,Enard W
Wed Feb 10 00:00:00 EST 2021
Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma.
Life science alliance
Regina C,Hamed E,Andrieux G,Angenendt S,Schneider M,Ku M,Follo M,Wachtel M,Ke E,Kikuchi K,Henssen AG,Schäfer BW,Boerries M,Wagers AJ,Keller C,Hettmer S
AF-100-18B was used in Cell Culture to study how heterogeneous expression of PAX3:FOXO1 at the single cell level may provide a critical advantage during tumor progression.
Wed Sep 01 00:00:00 EDT 2021
Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis.
Cell research
Wu J,Song D,Li Z,Guo B,Xiao Y,Liu W,Liang L,Feng C,Gao T,Chen Y,Li Y,Wang Z,Wen J,Yang S,Liu P,Wang L,Wang Y,Peng L,Stacey GN,Hu Z,Feng G,Li W,Huo Y,Jin R,Shyh-Chang N,Zhou Q,Wang L,Hu B,Dai H,Hao J
Tue Sep 01 00:00:00 EDT 2020
Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma.
Signal transduction and targeted therapy
Li L,Yang L,Fan Z,Xue W,Shen Z,Yuan Y,Sun X,Wang D,Lian J,Wang L,Zhao J,Zhang Y
Fri May 22 00:00:00 EDT 2020
Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide.
Science translational medicine
Montiel V,Bella R,Michel LYM,Esfahani H,De Mulder D,Robinson EL,Deglasse JP,Tiburcy M,Chow PH,Jonas JC,Gilon P,Steinhorn B,Michel T,Beauloye C,Bertrand L,Farah C,Dei Zotti F,Debaix H,Bouzin C,Brusa D,Horman S,Vanoverschelde JL,Bergmann O,Gilis D,Rooman M,Ghigo A,Geninatti-Crich S,Yool A,Zimmermann WH,Roderick HL,Devuyst O,Balligand JL
AF-100-18B was used in Cell Culture to investigate regulators of oxidant-mediated cardiac hypertrophy.
Wed Oct 07 00:00:00 EDT 2020
Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.
Neuron
Lin L,Zhang M,Stoilov P,Chen L,Zheng S
Wed Sep 23 00:00:00 EDT 2020
Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma.
Oncogene
Grassi ES,Pantazopoulou V,Pietras A
Fri May 01 00:00:00 EDT 2020
EZH2 facilitates BMI1-dependent hepatocarcinogenesis through epigenetically silencing microRNA-200c.
Oncogenesis
Xu L,Lin J,Deng W,Luo W,Huang Y,Liu CQ,Zhang FP,Qin YF,Wong PP,Liu C
Mon Nov 09 00:00:00 EST 2020
Platelet sonicates activate hair follicle stem cells and mediate enhanced hair follicle regeneration.
Journal of cellular and molecular medicine
Zhu M,Kong D,Tian R,Pang M,Mo M,Chen Y,Yang G,Liu Cheng H,Lei X,Fang K,Cheng B,Wu Y
Wed Jan 01 00:00:00 EST 2020
A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells.
Oncology letters
Qi SG,Quan LQ,Cui XY,Li HM,Zhao XD,Li RT
AF-100-18B was used in Cell Culture to study the antitumor activity of rupesin E in glioma stem cells (GSCs).
Sat Feb 01 00:00:00 EST 2020
Growth factors-based beneficial effects of platelet lysate on umbilical cord-derived stem cells and their synergistic use in osteoarthritis treatment.
Cell death & disease
Yan L,Zhou L,Yan B,Zhang L,Du W,Liu F,Yuan Q,Tong P,Shan L,Efferth T
Wed Oct 14 00:00:00 EDT 2020
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
Cell death discovery
Koch K,Hartmann R,Tsiampali J,Uhlmann C,Nickel AC,He X,Kamp MA,Sabel M,Barker RA,Steiger HJ,Hänggi D,Willbold D,Maciaczyk J,Kahlert UD
Tue Sep 26 00:00:00 EDT 2023
Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation.
Stem cell reports
Zhang W,Tian Y,Gao Q,Li X,Li Y,Zhang J,Yao C,Wang Y,Wang H,Zhao Y,Zhang Q,Li L,Yu Y,Fan Y,Shuai L
Tue Jul 14 00:00:00 EDT 2020
LncRNA NEAT1 remodels chromatin to promote the 5-Fu resistance by maintaining colorectal cancer stemness.
Cell death & disease
Zhu Y,Hu H,Yuan Z,Zhang Q,Xiong H,Hu Z,Wu H,Huang R,Wang G,Tang Q
Mon Nov 09 00:00:00 EST 2020
Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer.
International journal of molecular sciences
Li X,Strietz J,Bleilevens A,Stickeler E,Maurer J
AF-100-18B was used in Cell Culture to indicate that chemotherapeutic stress enhanced sphere forming capacity of BCSCs, and changed cell morphology and EMT-related gene expression at the mRNA level, whereas the migratory capacity was unaffected. Six miRNAs were identified as potential regulators in this process.
Wed Jan 08 00:00:00 EST 2020
Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells.
Nature communications
Kishimoto K,Furukawa KT,Luz-Madrigal A,Yamaoka A,Matsuoka C,Habu M,Alev C,Zorn AM,Morimoto M
Thu Aug 27 00:00:00 EDT 2020
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Cell death & disease
Jia Z,Zhang Y,Yan A,Wang M,Han Q,Wang K,Wang J,Qiao C,Pan Z,Chen C,Hu D,Ding X
Thu Aug 20 00:00:00 EDT 2020
Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth.
Scientific reports
Leventoux N,Augustus M,Azar S,Riquier S,Villemin JP,Guelfi S,Falha L,Bauchet L,Gozé C,Ritchie W,Commes T,Duffau H,Rigau V,Hugnot JP
Thu Mar 26 00:00:00 EDT 2020
Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation.
Nature communications
Patani H,Rushton MD,Higham J,Teijeiro SA,Oxley D,Cutillas P,Sproul D,Ficz G
Wed Jul 22 00:00:00 EDT 2020
Functional omics analyses reveal only minor effects of microRNAs on human somatic stem cell differentiation.
Scientific reports
Schira-Heinen J,Czapla A,Hendricks M,Kloetgen A,Wruck W,Adjaye J,Kögler G,Werner Müller H,Stühler K,Trompeter HI
Mon Feb 24 00:00:00 EST 2020
Endothelial Autophagy: an Effective Target for Radiation-induced Cerebral Capillary Damage.
Scientific reports
Ai X,Ye Z,Yao Y,Xiao J,You C,Xu J,Huang X,Zhong J,Fan M,Song X,Shi H,Zhang D,Zhao C
Fri Jan 17 00:00:00 EST 2020
LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells.
Stem cell research & therapy
He F,Li N,Huang HB,Wang JB,Yang XF,Wang HD,Huang W,Li FR
AF-100-18B was used in Cell Culture to investigate the role of LSD1 on insulin production from human embryonic stem cell line H9.
Tue Apr 28 00:00:00 EDT 2020
Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity.
Nature communications
Manzella G,Schreck LD,Breunis WB,Molenaar J,Merks H,Barr FG,Sun W,Römmele M,Zhang L,Tchinda J,Ngo QA,Bode P,Delattre O,Surdez D,Rekhi B,Niggli FK,Schäfer BW,Wachtel M
Tue Sep 15 00:00:00 EDT 2020
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.
Nature communications
Sun X,Peng X,Cao Y,Zhou Y,Sun Y
Fri Jun 12 00:00:00 EDT 2020
The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis.
Scientific reports
Griffiths R,Woods S,Cheng A,Wang P,Griffiths-Jones S,Ronshaugen M,Kimber SJ
Mon Mar 16 00:00:00 EDT 2020
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.
Nature communications
Matsumura K,Seiriki K,Okada S,Nagase M,Ayabe S,Yamada I,Furuse T,Shibuya H,Yasuda Y,Yamamori H,Fujimoto M,Nagayasu K,Yamamoto K,Kitagawa K,Miura H,Gotoda-Nishimura N,Igarashi H,Hayashida M,Baba M,Kondo M,Hasebe S,Ueshima K,Kasai A,Ago Y,Hayata-Takano A,Shintani N,Iguchi T,Sato M,Yamaguchi S,Tamura M,Wakana S,Yoshiki A,Watabe AM,Okano H,Takuma K,Hashimoto R,Hashimoto H,Nakazawa T
Wed Feb 26 00:00:00 EST 2020
Efficient Cardiac Differentiation of Human Amniotic Fluid-Derived Stem Cells into Induced Pluripotent Stem Cells and Their Potential Immune Privilege.
International journal of molecular sciences
Fang YH,Wang SPH,Gao ZH,Wu SN,Chang HY,Yang PJ,Liu PY,Liu YW
AF-100-18B was used in Cell Culture to generate hAFSC-derived induced PSCs (hAFSC-iPSCs) and use a Wnt-modulating differentiation protocol for the cardiac differentiation of hAFSC-iPSCs.
Sun Mar 29 00:00:00 EDT 2020
Generation of Engineered Human Myocardium in a Multi-well Format.
STAR protocols
Tiburcy M,Meyer T,Liaw NY,Zimmermann WH
Fri Jun 19 00:00:00 EDT 2020
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.
Cell
Neftel C,Laffy J,Filbin MG,Hara T,Shore ME,Rahme GJ,Richman AR,Silverbush D,Shaw ML,Hebert CM,Dewitt J,Gritsch S,Perez EM,Gonzalez Castro LN,Lan X,Druck N,Rodman C,Dionne D,Kaplan A,Bertalan MS,Small J,Pelton K,Becker S,Bonal D,Nguyen QD,Servis RL,Fung JM,Mylvaganam R,Mayr L,Gojo J,Haberler C,Geyeregger R,Czech T,Slavc I,Nahed BV,Curry WT,Carter BS,Wakimoto H,Brastianos PK,Batchelor TT,Stemmer-Rachamimov A,Martinez-Lage M,Frosch MP,Stamenkovic I,Riggi N,Rheinbay E,Monje M,Rozenblatt-Rosen O,Cahill DP,Patel AP,Hunter T,Verma IM,Ligon KL,Louis DN,Regev A,Bernstein BE,Tirosh I,Suvà ML
Thu Aug 08 00:00:00 EDT 2019
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.
Cell
Neftel C,Laffy J,Filbin MG,Hara T,Shore ME,Rahme GJ,Richman AR,Silverbush D,Shaw ML,Hebert CM,Dewitt J,Gritsch S,Perez EM,Gonzalez Castro LN,Lan X,Druck N,Rodman C,Dionne D,Kaplan A,Bertalan MS,Small J,Pelton K,Becker S,Bonal D,Nguyen QD,Servis RL,Fung JM,Mylvaganam R,Mayr L,Gojo J,Haberler C,Geyeregger R,Czech T,Slavc I,Nahed BV,Curry WT,Carter BS,Wakimoto H,Brastianos PK,Batchelor TT,Stemmer-Rachamimov A,Martinez-Lage M,Frosch MP,Stamenkovic I,Riggi N,Rheinbay E,Monje M,Rozenblatt-Rosen O,Cahill DP,Patel AP,Hunter T,Verma IM,Ligon KL,Louis DN,Regev A,Bernstein BE,Tirosh I,Suvà ML
Thu Aug 08 00:00:00 EDT 2019
Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN.
Neuron
Tang C,Wang M,Wang P,Wang L,Wu Q,Guo W
Wed Jan 02 00:00:00 EST 2019
Engineering, delivery, and biological validation of artificial microRNA clusters for gene therapy applications.
Nature protocols
Bhaskaran V,Yao Y,Bei F,Peruzzi P
AF-100-18B was used in Cell Culture to show that this protocol is quick and flexible and does not require special laboratory equipment or techniques, or multiple cloning steps.
Sun Dec 01 00:00:00 EST 2019
Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.
EMBO molecular medicine
Le Joncour V,Filppu P,Hyvönen M,Holopainen M,Turunen SP,Sihto H,Burghardt I,Joensuu H,Tynninen O,Jääskeläinen J,Weller M,Lehti K,Käkelä R,Laakkonen P
Sat Jun 01 00:00:00 EDT 2019
Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG.
Bone research
Chen CY,Rao SS,Tan YJ,Luo MJ,Hu XK,Yin H,Huang J,Hu Y,Luo ZW,Liu ZZ,Wang ZX,Cao J,Liu YW,Li HM,Chen Y,Du W,Liu JH,Zhang Y,Chen TH,Liu HM,Wu B,Yue T,Wang YY,Xia K,Lei PF,Tang SY,Xie H
Wed Sep 30 00:00:00 EDT 2020
Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival.
British journal of cancer
Rahman MA,Gras Navarro A,Brekke J,Engelsen A,Bindesbøll C,Sarowar S,Bahador M,Bifulco E,Goplen D,Waha A,Lie SA,Gjertsen BT,Selheim F,Enger PØ,Simonsen A,Chekenya M
Tue Oct 01 00:00:00 EDT 2019
Unbalanced YAP-SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma.
Oncogene
Wang L,Zhang Z,Yu X,Huang X,Liu Z,Chai Y,Yang L,Wang Q,Li M,Zhao J,Hou J,Li F
Fri Mar 01 00:00:00 EST 2019
Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.
Stem cells translational medicine
Trump LR,Nayak RC,Singh AK,Emberesh S,Wellendorf AM,Lutzko CM,Cancelas JA
Sat Jun 01 00:00:00 EDT 2019
Novel tumor suppressor role of miRNA-876 in cholangiocarcinoma.
Oncogenesis
Ursu S,Majid S,Garger C,de Semir D,Bezrookove V,Desprez PY,McAllister S,Soroceanu L,Nosrati M,Yimam K,Hassoun A,Osorio R,Kashani-Sabet M,Dar AA
Tue Aug 13 00:00:00 EDT 2019
A mechanistic evaluation of the angiogenic properties of a dehydrated amnion chorion membrane in vitro and in vivo.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
McQuilling JP,Burnette M,Kimmerling KA,Kammer M,Mowry KC
Fri Nov 01 00:00:00 EDT 2019
The testicular soma of Tsc22d3 knockout mice supports spermatogenesis and germline transmission from spermatogonial stem cell lines upon transplantation.
Genesis (New York, N.Y. : 2000)
Zhou H,Zeng Z,Koentgen F,Khan M,Mombaerts P
Sat Jun 01 00:00:00 EDT 2019
Long noncoding RNA ANCR inhibits the differentiation of mesenchymal stem cells toward definitive endoderm by facilitating the association of PTBP1 with ID2.
Cell death & disease
Li J,Yang Y,Fan J,Xu H,Fan L,Li H,Zhao RC
Mon Jun 24 00:00:00 EDT 2019
The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells.
The Journal of biological chemistry
Wang X,Wang X,Zhang S,Sun H,Li S,Ding H,You Y,Zhang X,Ye SD
Fri Apr 12 00:00:00 EDT 2019
The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells.
The Journal of biological chemistry
Wang X,Wang X,Zhang S,Sun H,Li S,Ding H,You Y,Zhang X,Ye SD
Fri Apr 12 00:00:00 EDT 2019
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription.
Nature communications
Yu JM,Sun W,Wang ZH,Liang X,Hua F,Li K,Lv XX,Zhang XW,Liu YY,Yu JJ,Liu SS,Shang S,Wang F,Yang ZN,Zhao CX,Hou XY,Li PP,Huang B,Cui B,Hu ZW
Mon Dec 16 00:00:00 EST 2019
Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease.
Scientific reports
Fujiyoshi J,Yamaza H,Sonoda S,Yuniartha R,Ihara K,Nonaka K,Taguchi T,Ohga S,Yamaza T
Thu Feb 07 00:00:00 EST 2019
CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line.
Cancer medicine
Asai R,Tsuchiya H,Amisaki M,Makimoto K,Takenaga A,Sakabe T,Hoi S,Koyama S,Shiota G
Fri Feb 01 00:00:00 EST 2019
Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts.
Nature communications
Redd MA,Zeinstra N,Qin W,Wei W,Martinson A,Wang Y,Wang RK,Murry CE,Zheng Y
Mon Feb 04 00:00:00 EST 2019
PIC&RUN: An integrated assay for the detection and retrieval of single viable circulating tumor cells.
Scientific reports
Kamal M,Saremi S,Klotz R,Iriondo O,Amzaleg Y,Chairez Y,Tulpule V,Lang JE,Kang I,Yu M
Mon Nov 25 00:00:00 EST 2019
Live-cell Migration Assays to Study Motility of Neural andGlial (Oligodendrocyte) Progenitor Cells.
Bio-protocol
Chen CY,Chou FS,Wang PS
AF-100-18B was used in Cell Culture to study the cell type-specific mechanisms underlying migration of lineage- or disease-specific cells, such as neural and glial progenitor cells using a live-cell migration assay for use in the assessment of neural and glial progenitor cell migration.
Thu Jun 20 00:00:00 EDT 2019
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.
Nature communications
Tang F,Gao R,Jeevan-Raj B,Wyss CB,Kalathur RKR,Piscuoglio S,Ng CKY,Hindupur SK,Nuciforo S,Dazert E,Bock T,Song S,Buechel D,Morini MF,Hergovich A,Matthias P,Lim DS,Terracciano LM,Heim MH,Hall MN,Christofori G
Tue Dec 17 00:00:00 EST 2019
Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells.
Scientific reports
Ballester M,Sentandreu E,Luongo G,Santamaria R,Bolonio M,Alcoriza-Balaguer MI,Palomino-Schätzlein M,Pineda-Lucena A,Castell J,Lahoz A,Bort R
Fri Nov 29 00:00:00 EST 2019
Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway.
Cell death & disease
Deshors P,Toulas C,Arnauduc F,Malric L,Siegfried A,Nicaise Y,Lemarié A,Larrieu D,Tosolini M,Cohen-Jonathan Moyal E,Courtade-Saidi M,Evrard SM
Mon Oct 28 00:00:00 EDT 2019
Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.
Cell chemical biology
Bum-Erdene K,Zhou D,Gonzalez-Gutierrez G,Ghozayel MK,Si Y,Xu D,Shannon HE,Bailey BJ,Corson TW,Pollok KE,Wells CD,Meroueh SO
AF-100-18B was used in Cell Culture to report small-molecule TEAD⋅Yap inhibitors that rapidly and selectively form a covalent bond with a conserved cysteine located within the unique deep hydrophobic palmitate-binding pocket of TEADs.
Thu Mar 21 00:00:00 EDT 2019
ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
Neuron
Rousseaux MWC,Tschumperlin T,Lu HC,Lackey EP,Bondar VV,Wan YW,Tan Q,Adamski CJ,Friedrich J,Twaroski K,Chen W,Tolar J,Henzler C,Sharma A,Bajić A,Lin T,Duvick L,Liu Z,Sillitoe RV,Zoghbi HY,Orr HT
Wed Mar 21 00:00:00 EDT 2018
FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis.
Neuron
Schäffner I,Minakaki G,Khan MA,Balta EA,Schlötzer-Schrehardt U,Schwarz TJ,Beckervordersandforth R,Winner B,Webb AE,DePinho RA,Paik J,Wurst W,Klucken J,Lie DC
Wed Sep 19 00:00:00 EDT 2018
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.
The Journal of experimental medicine
Chheda ZS,Kohanbash G,Okada K,Jahan N,Sidney J,Pecoraro M,Yang X,Carrera DA,Downey KM,Shrivastav S,Liu S,Lin Y,Lagisetti C,Chuntova P,Watchmaker PB,Mueller S,Pollack IF,Rajalingam R,Carcaboso AM,Mann M,Sette A,Garcia KC,Hou Y,Okada H
AF-100-18B was used in Cell Culture to assess whether targeting the neoantigen resulting from the histone 3 variant H3.3K27M mutation is therapeutically viable in T cell-based therapy for glioma.
Tue Jan 02 00:00:00 EST 2018
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.
The Journal of experimental medicine
Chheda ZS,Kohanbash G,Okada K,Jahan N,Sidney J,Pecoraro M,Yang X,Carrera DA,Downey KM,Shrivastav S,Liu S,Lin Y,Lagisetti C,Chuntova P,Watchmaker PB,Mueller S,Pollack IF,Rajalingam R,Carcaboso AM,Mann M,Sette A,Garcia KC,Hou Y,Okada H
AF-100-18B was used in Cell Culture to assess whether targeting the neoantigen resulting from the histone 3 variant H3.3K27M mutation is therapeutically viable in T cell-based therapy for glioma.
Tue Jan 02 00:00:00 EST 2018
Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages.
Developmental cell
van Boxtel AL,Economou AD,Heliot C,Hill CS
AF-100-18B was used in In vitro experiments to demonstrate that Nodal simultaneously induces the expression of secreted Fgf ligands and the cell-autonomous Fgf signaling inhibitor Dusp4 in zebrafish.
Mon Jan 22 00:00:00 EST 2018
Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome.
Scientific reports
Piippo N,Korhonen E,Hytti M,Skottman H,Kinnunen K,Josifovska N,Petrovski G,Kaarniranta K,Kauppinen A
Mon Apr 30 00:00:00 EDT 2018
Engraftment of Human Pluripotent Stem Cell-derived Progenitors in the Inner Ear of Prenatal Mice.
Scientific reports
Takeda H,Hosoya M,Fujioka M,Saegusa C,Saeki T,Miwa T,Okano H,Minoda R
Wed Jan 31 00:00:00 EST 2018
MiR-205-5p inhibition by locked nucleic acids impairs metastatic potential of breast cancer cells.
Cell death & disease
De Cola A,Lamolinara A,Lanuti P,Rossi C,Iezzi M,Marchisio M,Todaro M,De Laurenzi V
Thu Jul 26 00:00:00 EDT 2018
A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors.
Cell reports
Wu J,Matthias N,Lo J,Ortiz-Vitali JL,Shieh AW,Wang SH,Darabi R
AF-100-18B was used in Sample Preparation (FC/FACS) to study myogenic differentiation of human pluripotent stem cells using double-reporter cell resource and defined an improved myogenic differentiation and purification strategy.
Tue Nov 13 00:00:00 EST 2018
Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway.
Cell death & disease
Wang L,Dong X,Ren Y,Luo J,Liu P,Su D,Yang X
Fri Jan 26 00:00:00 EST 2018
Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites.
Cell death & disease
Xie Y,Zhang H,Guo XJ,Feng YC,He RZ,Li X,Yu S,Zhao Y,Shen M,Zhu F,Wang X,Wang M,Balakrishnan A,Ott M,Peng F,Qin RY
Wed Feb 14 00:00:00 EST 2018
A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells.
Scientific reports
Yamashita K,Hatou S,Inagaki E,Higa K,Tsubota K,Shimmura S
Thu Nov 15 00:00:00 EST 2018
Optimization of the use of a pharmaceutical grade xeno-free medium for in vitro expansion of human mesenchymal stem/stromal cells.
Journal of tissue engineering and regenerative medicine
Cimino M,Gonçalves RM,Bauman E,Barroso-Vilares M,Logarinho E,Barrias CC,Martins MCL
AF-100-18B was used in In vitro experiments to report the optimization of a pharmaceutical-grade xeno-free strategy for hMSCs in vitro expansion based on the supplementation of basal medium with a pharmaceutical-grade human plasma-derived supplement for cell culture (SCC) and 2 human growth factors (bFGF and TGFβ1), plus a coating of human plasma fibronectin (Fn).
Thu Mar 01 00:00:00 EST 2018
Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis.
Scientific reports
Tawarayama H,Yamada H,Amin R,Morita-Fujimura Y,Cooper HM,Shinmyo Y,Kawata M,Ikawa S,Tanaka H
Tue Jan 16 00:00:00 EST 2018
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.
Nature communications
Jun HJ,Appleman VA,Wu HJ,Rose CM,Pineda JJ,Yeo AT,Delcuze B,Lee C,Gyuris A,Zhu H,Woolfenden S,Bronisz A,Nakano I,Chiocca EA,Bronson RT,Ligon KL,Sarkaria JN,Gygi SP,Michor F,Mitchison TJ,Charest A
Mon Aug 06 00:00:00 EDT 2018
Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.
Scientific reports
Sahakyan V,Duelen R,Tam WL,Roberts SJ,Grosemans H,Berckmans P,Ceccarelli G,Pelizzo G,Broccoli V,Deprest J,Luyten FP,Verfaillie CM,Sampaolesi M
Tue Feb 13 00:00:00 EST 2018
Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression.
Scientific reports
Bosnakovski D,Gearhart MD,Toso EA,Ener ET,Choi SH,Kyba M
Fri Nov 16 00:00:00 EST 2018
DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/β-catenin pathway via GSK3β.
Cell death & disease
Liu XF,Li XY,Zheng PS,Yang WT
Thu Mar 01 00:00:00 EST 2018
KDM4 Inhibition Targets Breast Cancer Stem-like Cells.
Cancer research
Metzger E,Stepputtis SS,Strietz J,Preca BT,Urban S,Willmann D,Allen A,Zenk F,Iovino N,Bronsert P,Proske A,Follo M,Boerries M,Stickeler E,Xu J,Wallace MB,Stafford JA,Kanouni T,Maurer J,Schüle R
AF-100-18B was used in Cell Culture to validate a BCSC culture system for drug screening and proof of concept for KDM4 inhibition as a triple-negative breast cancer treatment.
Wed Nov 01 00:00:00 EDT 2017
Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells.
Oncogene
Kawauchi D,Ogg RJ,Liu L,Shih DJH,Finkelstein D,Murphy BL,Rehg JE,Korshunov A,Calabrese C,Zindy F,Phoenix T,Kawaguchi Y,Gronych J,Gilbertson RJ,Lichter P,Gajjar A,Kool M,Northcott PA,Pfister SM,Roussel MF
Thu Sep 14 00:00:00 EDT 2017
Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy.
Stem cells translational medicine
Meneghini V,Frati G,Sala D,De Cicco S,Luciani M,Cavazzin C,Paulis M,Mentzen W,Morena F,Giannelli S,Sanvito F,Villa A,Bulfone A,Broccoli V,Martino S,Gritti A
Wed Feb 01 00:00:00 EST 2017
Preclinical Analysis of Fetal Human Mesencephalic Neural Progenitor Cell Lines: Characterization and Safety In Vitro and In Vivo.
Stem cells translational medicine
Moon J,Schwarz SC,Lee HS,Kang JM,Lee YE,Kim B,Sung MY,Höglinger G,Wegner F,Kim JS,Chung HM,Chang SW,Cha KY,Kim KS,Schwarz J
Wed Feb 01 00:00:00 EST 2017
Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-β1.
Stem cells translational medicine
Gimeno ML,Fuertes F,Barcala Tabarrozzi AE,Attorressi AI,Cucchiani R,Corrales L,Oliveira TC,Sogayar MC,Labriola L,Dewey RA,Perone MJ
Sun Jan 01 00:00:00 EST 2017
Neural Progenitor-Like Cells Induced from Human Gingiva-Derived Mesenchymal Stem Cells Regulate Myelination of Schwann Cells in Rat Sciatic Nerve Regeneration.
Stem cells translational medicine
Zhang Q,Nguyen P,Xu Q,Park W,Lee S,Furuhashi A,Le AD
Wed Feb 01 00:00:00 EST 2017
Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells.
Stem cells translational medicine
Wang JY,Wu PK,Chen PC,Lee CW,Chen WM,Hung SC
Wed Feb 01 00:00:00 EST 2017
Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells with Distinctive Paracrine and Plasticity Properties.
Stem cells translational medicine
Chimenti I,Pagano F,Angelini F,Siciliano C,Mangino G,Picchio V,De Falco E,Peruzzi M,Carnevale R,Ibrahim M,Biondi-Zoccai G,Messina E,Frati G
Wed Mar 01 00:00:00 EST 2017
Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling.
Stem cells translational medicine
Wilkinson DC,Alva-Ornelas JA,Sucre JM,Vijayaraj P,Durra A,Richardson W,Jonas SJ,Paul MK,Karumbayaram S,Dunn B,Gomperts BN
Wed Feb 01 00:00:00 EST 2017
Efficacy of Two Delivery Routes for Transplanting Human Neural Progenitor Cells (NPCs) Into the Spastic Han-Wistar Rat, a Model of Ataxia.
Cell transplantation
Uhlendorf TL,Nuryyev RL,Kopyov AO,Ochoa J,Younesi S,Cohen RW,Kopyov OV
AF-100-18B was used in Cell Culture to show that direct implantation of hNPCs reduced ataxic symptoms in the sHW rat, demonstrating that stereotactic route of stem cell delivery correlates to improved clinical outcomes.
Thu Feb 16 00:00:00 EST 2017
Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice.
The Journal of biological chemistry
Liu J,Shang D,Xiao Y,Zhong P,Cheng H,Zhou R
Fri Sep 29 00:00:00 EDT 2017
Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells.
Scientific reports
Wahlin KJ,Maruotti JA,Sripathi SR,Ball J,Angueyra JM,Kim C,Grebe R,Li W,Jones BW,Zack DJ
AF-100-18B was used in Cell Culture to study an in vitro method for human pluripotent stem cells (hPSC) differentiation into 3D retinas with at least some important features reminiscent of mature retina, including exuberant outgrowth of outer segment-like structures and synaptic ribbons, photoreceptor neurotransmitter expression, and membrane conductances and synaptic vesicle release properties consistent with possible photoreceptor synaptic function.
Mon Apr 10 00:00:00 EDT 2017
Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex.
Cell stem cell
Bifari F,Decimo I,Pino A,Llorens-Bobadilla E,Zhao S,Lange C,Panuccio G,Boeckx B,Thienpont B,Vinckier S,Wyns S,Bouché A,Lambrechts D,Giugliano M,Dewerchin M,Martin-Villalba A,Carmeliet P
AF-100-18B was used in In vitro experiments to identify radial glia-like cells present in the meninges that migrate and differentiate into functional neurons in the neonatal cerebral cortex.
Thu Mar 02 00:00:00 EST 2017
DLL4 overexpression increases gastric cancer stem/progenitor cell self-renewal ability and correlates with poor clinical outcome via Notch-1 signaling pathway activation.
Cancer medicine
Miao ZF,Xu H,Xu HM,Wang ZN,Zhao TT,Song YX,Xu YY
Sun Jan 01 00:00:00 EST 2017
Methanobactin reverses acute liver failure in a rat model of Wilson disease.
The Journal of clinical investigation
Lichtmannegger J,Leitzinger C,Wimmer R,Schmitt S,Schulz S,Kabiri Y,Eberhagen C,Rieder T,Janik D,Neff F,Straub BK,Schirmacher P,DiSpirito AA,Bandow N,Baral BS,Flatley A,Kremmer E,Denk G,Reiter FP,Hohenester S,Eckardt-Schupp F,Dencher NA,Adamski J,Sauer V,Niemietz C,Schmidt HH,Merle U,Gotthardt DN,Kroemer G,Weiss KH,Zischka H
Fri Jul 01 00:00:00 EDT 2016
A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.
EMBO molecular medicine
Sala L,Yu Z,Ward-van Oostwaard D,van Veldhoven JP,Moretti A,Laugwitz KL,Mummery CL,IJzerman AP,Bellin M
Thu Sep 01 00:00:00 EDT 2016
FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma.
The EMBO journal
Suryo Rahmanto A,Savov V,Brunner A,Bolin S,Weishaupt H,Malyukova A,Rosén G,Čančer M,Hutter S,Sundström A,Kawauchi D,Jones DT,Spruck C,Taylor MD,Cho YJ,Pfister SM,Kool M,Korshunov A,Swartling FJ,Sangfelt O
Mon Oct 17 00:00:00 EDT 2016
3D Bioprinting Using a Templated Porous Bioink.
Advanced healthcare materials
Armstrong JP,Burke M,Carter BM,Davis SA,Perriman AW
Fri Jul 01 00:00:00 EDT 2016
Proteomics and transcriptomics of peripheral nerve tissue and cells unravel new aspects of the human Schwann cell repair phenotype.
Glia
Weiss T,Taschner-Mandl S,Bileck A,Slany A,Kromp F,Rifatbegovic F,Frech C,Windhager R,Kitzinger H,Tzou CH,Ambros PF,Gerner C,Ambros IM
Thu Dec 01 00:00:00 EST 2016
Novel 3-D cell culture system for in vitro evaluation of anticancer drugs under anchorage-independent conditions.
Cancer science
Aihara A,Abe N,Saruhashi K,Kanaki T,Nishino T
Thu Dec 01 00:00:00 EST 2016
Impact of Sulfatase-2 on cancer progression and prognosis in patients with renal cell carcinoma.
Cancer science
Kumagai S,Ishibashi K,Kataoka M,Oguro T,Kiko Y,Yanagida T,Aikawa K,Kojima Y
Tue Nov 01 00:00:00 EDT 2016
Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
Stem cells (Dayton, Ohio)
Iseki H,Nakachi Y,Hishida T,Yamashita-Sugahara Y,Hirasaki M,Ueda A,Tanimoto Y,Iijima S,Sugiyama F,Yagami K,Takahashi S,Okuda A,Okazaki Y
Mon Feb 01 00:00:00 EST 2016
Necdin controls EGFR signaling linked to astrocyte differentiation in primary cortical progenitor cells.
Cellular signalling
Fujimoto I,Hasegawa K,Fujiwara K,Yamada M,Yoshikawa K
Mon Feb 01 00:00:00 EST 2016
Detecting the H3F3A mutant allele found in high-grade pediatric glioma by real-time PCR.
Journal of neuro-oncology
Zhang R,Han J,Daniels D,Huang H,Zhang Z
AF-100-18B was used in Cell Culture to describe a real-time PCR-based procedure involving a mutant-specific primer, a blocker of oligonucleotide, and a reverse primer that can differentiate samples with the H3F3A K27M mutation from those that do not.
Fri Jan 01 00:00:00 EST 2016
Vitrified canine testicular cells allow the formation of spermatogonial stem cells and seminiferous tubules following their xenotransplantation into nude mice.
Scientific reports
Lee KH,Lee WY,Kim DH,Lee SH,Do JT,Park C,Kim JH,Choi YS,Song H
Wed Feb 24 00:00:00 EST 2016
Aldh1 Expression and Activity Increase During Tumor Evolution in Sarcoma Cancer Stem Cell Populations.
Scientific reports
Martinez-Cruzado L,Tornin J,Santos L,Rodriguez A,García-Castro J,Morís F,Rodriguez R
Mon Jun 13 00:00:00 EDT 2016
Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates.
Scientific reports
Ding X,Liu G,Xu B,Wu C,Hui N,Ni X,Wang J,Du M,Teng X,Wu J
Thu Jun 30 00:00:00 EDT 2016
Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates.
Scientific reports
Ding X,Liu G,Xu B,Wu C,Hui N,Ni X,Wang J,Du M,Teng X,Wu J
Thu Jun 30 00:00:00 EDT 2016
Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions.
Scientific reports
Sugimoto K,Miyata Y,Nakayama T,Saito S,Suzuki R,Hayakawa F,Nishiwaki S,Mizuno H,Takeshita K,Kato H,Ueda R,Takami A,Naoe T
Tue Aug 02 00:00:00 EDT 2016
Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions.
Scientific reports
Sugimoto K,Miyata Y,Nakayama T,Saito S,Suzuki R,Hayakawa F,Nishiwaki S,Mizuno H,Takeshita K,Kato H,Ueda R,Takami A,Naoe T
Tue Aug 02 00:00:00 EDT 2016
Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions.
Scientific reports
Sugimoto K,Miyata Y,Nakayama T,Saito S,Suzuki R,Hayakawa F,Nishiwaki S,Mizuno H,Takeshita K,Kato H,Ueda R,Takami A,Naoe T
Tue Aug 02 00:00:00 EDT 2016
Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice.
Cell death & disease
Lin Y,Zhang JC,Yao CY,Wu Y,Abdelgawad AF,Yao SL,Yuan SY
Thu Jun 23 00:00:00 EDT 2016
Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
Nature communications
Hasegawa K,Yasuda T,Shiraishi C,Fujiwara K,Przedborski S,Mochizuki H,Yoshikawa K
Mon Mar 14 00:00:00 EDT 2016
Molecular identity of human outer radial glia during cortical development.
Cell
Pollen AA,Nowakowski TJ,Chen J,Retallack H,Sandoval-Espinosa C,Nicholas CR,Shuga J,Liu SJ,Oldham MC,Diaz A,Lim DA,Leyrat AA,West JA,Kriegstein AR
Thu Sep 24 00:00:00 EDT 2015
Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.
The Journal of clinical investigation
Nayak RC,Trump LR,Aronow BJ,Myers K,Mehta P,Kalfa T,Wellendorf AM,Valencia CA,Paddison PJ,Horwitz MS,Grimes HL,Lutzko C,Cancelas JA
Mon Aug 03 00:00:00 EDT 2015
The Axolotl Fibula as a Model for the Induction of Regeneration across Large Segment Defects in Long Bones of the Extremities.
PloS one
Chen X,Song F,Jhamb D,Li J,Bottino MC,Palakal MJ,Stocum DL
AF-100-18B was used in In vitro experiments to study the ability of the axolotl (Ambystoma mexicanum) fibula to regenerate across segment defects of different size in the absence of intervention or after implant of a unique 8-braid pig small intestine submucosa (SIS) scaffold, with or without incorporated growth factor combinations or tissue protein extract.
Mon Apr 25 00:00:00 EDT 2016
The Axolotl Fibula as a Model for the Induction of Regeneration across Large Segment Defects in Long Bones of the Extremities.
PloS one
Chen X,Song F,Jhamb D,Li J,Bottino MC,Palakal MJ,Stocum DL
AF-100-18B was used in In vitro experiments to study the ability of the axolotl (Ambystoma mexicanum) fibula to regenerate across segment defects of different size in the absence of intervention or after implant of a unique 8-braid pig small intestine submucosa (SIS) scaffold, with or without incorporated growth factor combinations or tissue protein extract.
Mon Apr 25 00:00:00 EDT 2016
Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells.
Cell death & disease
Oliveira LM,Falomir-Lockhart LJ,Botelho MG,Lin KH,Wales P,Koch JC,Gerhardt E,Taschenberger H,Outeiro TF,Lingor P,Schüle B,Arndt-Jovin DJ,Jovin TM
Thu Nov 26 00:00:00 EST 2015
Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint.
Scientific reports
Li Y,El Mozen LA,Cai H,Fang W,Meng Q,Li J,Deng M,Long X
Fri Mar 06 00:00:00 EST 2015
Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells.
The Journal of biological chemistry
Aki S,Yoshioka K,Okamoto Y,Takuwa N,Takuwa Y
Fri Mar 06 00:00:00 EST 2015
The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells.
The Journal of biological chemistry
Hiemer SE,Szymaniak AD,Varelas X
Fri May 09 00:00:00 EDT 2014
Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques.
The Journal of clinical investigation
Hayashi T,Wakao S,Kitada M,Ose T,Watabe H,Kuroda Y,Mitsunaga K,Matsuse D,Shigemoto T,Ito A,Ikeda H,Fukuyama H,Onoe H,Tabata Y,Dezawa M
Tue Jan 01 00:00:00 EST 2013
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
The Journal of clinical investigation
Niola F,Zhao X,Singh D,Sullivan R,Castano A,Verrico A,Zoppoli P,Friedmann-Morvinski D,Sulman E,Barrett L,Zhuang Y,Verma I,Benezra R,Aldape K,Iavarone A,Lasorella A
Tue Jan 01 00:00:00 EST 2013
Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme.
Oncogene
Wang Y,Moncayo G,Morin P,Xue G,Grzmil M,Lino MM,Clément-Schatlo V,Frank S,Merlo A,Hemmings BA
Thu Feb 14 00:00:00 EST 2013
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.
The Journal of cell biology
Ahmed Z,Lin CC,Suen KM,Melo FA,Levitt JA,Suhling K,Ladbury JE
Mon Feb 18 00:00:00 EST 2013
Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.
Stem cells (Dayton, Ohio)
White MP,Rufaihah AJ,Liu L,Ghebremariam YT,Ivey KN,Cooke JP,Srivastava D
Tue Jan 01 00:00:00 EST 2013
Glioma stem cell-targeted dendritic cells as a tumor vaccine against malignant glioma.
Yonsei medical journal
Ji B,Chen Q,Liu B,Wu L,Tian D,Guo Z,Yi W
Tue Jan 01 00:00:00 EST 2013
Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model.
Journal of translational medicine
Touboul C,Lis R,Al Farsi H,Raynaud CM,Warfa M,Althawadi H,Mery E,Mirshahi M,Rafii A
Thu Jan 31 00:00:00 EST 2013
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
The Journal of biological chemistry
Yamaguchi Y,Shao Z,Sharif S,Du XY,Myles T,Merchant M,Harsh G,Glantz M,Recht L,Morser J,Leung LL
Fri Feb 01 00:00:00 EST 2013
Krüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells.
PloS one
Leng Z,Tao K,Xia Q,Tan J,Yue Z,Chen J,Xi H,Li J,Zheng H
Tue Aug 27 00:00:00 EDT 2013
Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress.
Scientific reports
Yang PM,Lin YT,Shun CT,Lin SH,Wei TT,Chuang SH,Wu MS,Chen CC
Thu Nov 14 00:00:00 EST 2013
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.
Cell death & disease
Lundholm L,Hååg P,Zong D,Juntti T,Mörk B,Lewensohn R,Viktorsson K
Thu Jan 31 00:00:00 EST 2013
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Nature
Wilson TR,Fridlyand J,Yan Y,Penuel E,Burton L,Chan E,Peng J,Lin E,Wang Y,Sosman J,Ribas A,Li J,Moffat J,Sutherlin DP,Koeppen H,Merchant M,Neve R,Settleman J
Thu Jul 26 00:00:00 EDT 2012
The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.
Nature
Mansour AA,Gafni O,Weinberger L,Zviran A,Ayyash M,Rais Y,Krupalnik V,Zerbib M,Amann-Zalcenstein D,Maza I,Geula S,Viukov S,Holtzman L,Pribluda A,Canaani E,Horn-Saban S,Amit I,Novershtern N,Hanna JH
Thu Aug 16 00:00:00 EDT 2012
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development.
Cell
Paige SL,Thomas S,Stoick-Cooper CL,Wang H,Maves L,Sandstrom R,Pabon L,Reinecke H,Pratt G,Keller G,Moon RT,Stamatoyannopoulos J,Murry CE
Fri Sep 28 00:00:00 EDT 2012
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.
Cell
Van Handel B,Montel-Hagen A,Sasidharan R,Nakano H,Ferrari R,Boogerd CJ,Schredelseker J,Wang Y,Hunter S,Org T,Zhou J,Li X,Pellegrini M,Chen JN,Orkin SH,Kurdistani SK,Evans SM,Nakano A,Mikkola HK
Fri Aug 03 00:00:00 EDT 2012
A mouse model of the most aggressive subgroup of human medulloblastoma.
Cancer cell
Kawauchi D,Robinson G,Uziel T,Gibson P,Rehg J,Gao C,Finkelstein D,Qu C,Pounds S,Ellison DW,Gilbertson RJ,Roussel MF
Tue Feb 14 00:00:00 EST 2012
The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas.
Cancer cell
Binda E,Visioli A,Giani F,Lamorte G,Copetti M,Pitter KL,Huse JT,Cajola L,Zanetti N,DiMeco F,De Filippis L,Mangiola A,Maira G,Anile C,De Bonis P,Reynolds BA,Pasquale EB,Vescovi AL
Tue Dec 11 00:00:00 EST 2012
Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.
Cancer cell
Swartling FJ,Savov V,Persson AI,Chen J,Hackett CS,Northcott PA,Grimmer MR,Lau J,Chesler L,Perry A,Phillips JJ,Taylor MD,Weiss WA
Tue May 15 00:00:00 EDT 2012
Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.
Blood
Kumano K,Arai S,Hosoi M,Taoka K,Takayama N,Otsu M,Nagae G,Ueda K,Nakazaki K,Kamikubo Y,Eto K,Aburatani H,Nakauchi H,Kurokawa M
Thu Jun 28 00:00:00 EDT 2012
APELIN promotes hematopoiesis from human embryonic stem cells.
Blood
Yu QC,Hirst CE,Costa M,Ng ES,Schiesser JV,Gertow K,Stanley EG,Elefanty AG
Thu Jun 28 00:00:00 EDT 2012
Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells.
The Journal of clinical investigation
Varela C,Denis JA,Polentes J,Feyeux M,Aubert S,Champon B,Piétu G,Peschanski M,Lefort N
Wed Feb 01 00:00:00 EST 2012
Transposon-mediated BAC transgenesis in human ES cells.
Nucleic acids research
Rostovskaya M,Fu J,Obst M,Baer I,Weidlich S,Wang H,Smith AJ,Anastassiadis K,Stewart AF
Mon Oct 01 00:00:00 EDT 2012
Transposon-mediated BAC transgenesis in human ES cells.
Nucleic acids research
Rostovskaya M,Fu J,Obst M,Baer I,Weidlich S,Wang H,Smith AJ,Anastassiadis K,Stewart AF
Mon Oct 01 00:00:00 EDT 2012
Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.
EMBO molecular medicine
Sánchez-Danés A,Richaud-Patin Y,Carballo-Carbajal I,Jiménez-Delgado S,Caig C,Mora S,Di Guglielmo C,Ezquerra M,Patel B,Giralt A,Canals JM,Memo M,Alberch J,López-Barneo J,Vila M,Cuervo AM,Tolosa E,Consiglio A,Raya A
Tue May 01 00:00:00 EDT 2012
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.
Proceedings of the National Academy of Sciences of the United States of America
Giorgetti A,Marchetto MC,Li M,Yu D,Fazzina R,Mu Y,Adamo A,Paramonov I,Cardoso JC,Monasterio MB,Bardy C,Cassiani-Ingoni R,Liu GH,Gage FH,Izpisua Belmonte JC
Tue Jul 31 00:00:00 EDT 2012
Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells.
Environmental health perspectives
Kim MJ,Pelloux V,Guyot E,Tordjman J,Bui LC,Chevallier A,Forest C,Benelli C,Clément K,Barouki R
Sun Apr 01 00:00:00 EDT 2012
The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation.
British journal of cancer
Isham CR,Tibodeau JD,Bossou AR,Merchan JR,Bible KC
Tue Jan 17 00:00:00 EST 2012
Treatment of breast cancer stem cells with oncolytic herpes simplex virus.
Cancer gene therapy
Li J,Zeng W,Huang Y,Zhang Q,Hu P,Rabkin SD,Liu R
Mon Oct 01 00:00:00 EDT 2012
Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio)
Nefzger CM,Su CT,Fabb SA,Hartley BJ,Beh SJ,Zeng WR,Haynes JM,Pouton CW
Sun Jul 01 00:00:00 EDT 2012
Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity.
Stem cells (Dayton, Ohio)
Voon DC,Wang H,Koo JK,Nguyen TA,Hor YT,Chu YS,Ito K,Fukamachi H,Chan SL,Thiery JP,Ito Y
Mon Oct 01 00:00:00 EDT 2012
MicroRNAs regulate p21(Waf1/Cip1) protein expression and the DNA damage response in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Dolezalova D,Mraz M,Barta T,Plevova K,Vinarsky V,Holubcova Z,Jaros J,Dvorak P,Pospisilova S,Hampl A
Sun Jul 01 00:00:00 EDT 2012
Grafted neuronal precursor cells differentiate and integrate in injured hippocampus in experimental pneumococcal meningitis.
Stem cells (Dayton, Ohio)
Hofer S,Magloire V,Streit J,Leib SL
Fri Jun 01 00:00:00 EDT 2012
Two preferentially expressed proteins protect vascular endothelial cells from an attack by peptide-specific CTL.
Journal of immunology (Baltimore, Md. : 1950)
Thommen DS,Schuster H,Keller M,Kapoor S,Weinzierl AO,Chennakesava CS,Wang X,Rohrer L,von Eckardstein A,Stevanovic S,Biedermann BC
Fri Jun 01 00:00:00 EDT 2012
FGF2 mediates DNA repair in epidermoid carcinoma cells exposed to ionizing radiation.
International journal of radiation biology
Marie M,Hafner S,Moratille S,Vaigot P,Mine S,Rigaud O,Martin MT
Mon Oct 01 00:00:00 EDT 2012
Chondrogenic phenotype of different cells encapsulated in κ-carrageenan hydrogels for cartilage regeneration strategies.
Biotechnology and applied biochemistry
Popa E,Reis R,Gomes M
AF-100-18B was used in Cell Culture to investigate hydrogel articolar cartilage in regenerative medicine.
Mon Oct 21 00:00:00 EDT 2013
Generation of virus-free induced pluripotent stem cell clones on a synthetic matrix via a single cell subcloning in the naïve state.
PloS one
Nishishita N,Shikamura M,Takenaka C,Takada N,Fusaki N,Kawamata S
Thu Dec 13 00:00:00 EST 2012
Targeting JNK for therapeutic depletion of stem-like glioblastoma cells.
Scientific reports
Matsuda K,Sato A,Okada M,Shibuya K,Seino S,Suzuki K,Watanabe E,Narita Y,Shibui S,Kayama T,Kitanaka C
Sun Mar 17 00:00:00 EDT 2013
Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma.
PloS one
Lou E,Fujisawa S,Morozov A,Barlas A,Romin Y,Dogan Y,Gholami S,Moreira AL,Manova-Todorova K,Moore MA
Mon Aug 20 00:00:00 EDT 2012
Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease.
BMC neuroscience
El-Akabawy G,Rattray I,Johansson SM,Gale R,Bates G,Modo M
Thu Aug 09 00:00:00 EDT 2012
Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming.
PloS one
Chen M,Huang J,Yang X,Liu B,Zhang W,Huang L,Deng F,Ma J,Bai Y,Lu R,Huang B,Gao Q,Zhuo Y,Ge J
Mon Nov 19 00:00:00 EST 2012
Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming.
PloS one
Chen M,Huang J,Yang X,Liu B,Zhang W,Huang L,Deng F,Ma J,Bai Y,Lu R,Huang B,Gao Q,Zhuo Y,Ge J
Mon Nov 19 00:00:00 EST 2012
Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.
PloS one
Danova-Alt R,Heider A,Egger D,Cross M,Alt R
Tue Aug 07 00:00:00 EDT 2012
Characterization of liposarcoma cell lines for preclinical and biological studies.
Sarcoma
Stratford EW,Castro R,Daffinrud J,Skårn M,Lauvrak S,Munthe E,Myklebost O
Thu Aug 23 00:00:00 EDT 2012
Identification and characterisation of the early differentiating cells in neural differentiation of human embryonic stem cells.
PloS one
Noisa P,Ramasamy TS,Lamont FR,Yu JS,Sheldon MJ,Russell A,Jin X,Cui W
Tue Jan 08 00:00:00 EST 2013
Differential gene expression profile associated with the abnormality of bone marrow mesenchymal stem cells in aplastic anemia.
PloS one
Li J,Yang S,Lu S,Zhao H,Feng J,Li W,Ma F,Ren Q,Liu B,Zhang L,Zheng Y,Han ZC
Thu Apr 25 00:00:00 EDT 2013
Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation.
The Journal of biological chemistry
Spelat R,Ferro F,Curcio F
Fri Nov 02 00:00:00 EDT 2012
Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics.
PloS one
Ferro F,Spelat R,D'Aurizio F,Puppato E,Pandolfi M,Beltrami AP,Cesselli D,Falini G,Beltrami CA,Curcio F
Wed Nov 28 00:00:00 EST 2012
Concentration- and time-dependent response of human gingival fibroblasts to fibroblast growth factor 2 immobilized on titanium dental implants.
International journal of nanomedicine
Ma Q,Wang W,Chu PK,Mei S,Ji K,Jin L,Zhang Y
Wed Sep 26 00:00:00 EDT 2012
Concentration- and time-dependent response of human gingival fibroblasts to fibroblast growth factor 2 immobilized on titanium dental implants.
International journal of nanomedicine
Ma Q,Wang W,Chu PK,Mei S,Ji K,Jin L,Zhang Y
Wed Sep 26 00:00:00 EDT 2012
Retinoic acid-dependent signaling pathways and lineage events in the developing mouse spinal cord.
PloS one
Paschaki M,Lin SC,Wong RL,Finnell RH,Dollé P,Niederreither K
Mon Jul 23 00:00:00 EDT 2012
Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells.
BMC cancer
Monticone M,Daga A,Candiani S,Romeo F,Mirisola V,Viaggi S,Melloni I,Pedemonte S,Zona G,Giaretti W,Pfeffer U,Castagnola P
Fri Aug 17 00:00:00 EDT 2012
Directed induction of functional motor neuron-like cells from genetically engineered human mesenchymal stem cells.
PloS one
Park HW,Cho JS,Park CK,Jung SJ,Park CH,Lee SJ,Oh SB,Park YS,Chang MS
Thu Aug 23 00:00:00 EDT 2012
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
PloS one
Pelosi E,Castelli G,Martin-Padura I,Bordoni V,Santoro S,Conigliaro A,Cerio AM,De Santis Puzzonia M,Marighetti P,Biffoni M,Alonzi T,Amicone L,Alcalay M,Bertolini F,Testa U,Tripodi M
Tue May 21 00:00:00 EDT 2013
Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells.
PloS one
Rodríguez-Martínez G,Molina-Hernández A,Velasco I
Tue Jan 29 00:00:00 EST 2013
Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line.
BMC cancer
Martins-Neves SR,Lopes ÁO,do Carmo A,Paiva AA,Simões PC,Abrunhosa AJ,Gomes CM
Wed Apr 04 00:00:00 EDT 2012
Immunotherapy against the radial glia marker GLAST effectively triggers specific antitumor effectors without autoimmunity.
Oncoimmunology
Cantini G,Pisati F,Pessina S,Finocchiaro G,Pellegatta S
Sat Sep 01 00:00:00 EDT 2012
Satellite cell heterogeneity revealed by G-Tool, an open algorithm to quantify myogenesis through colony-forming assays.
Skeletal muscle
Ippolito J,Arpke RW,Haider KT,Zhang J,Kyba M
Fri Jun 15 00:00:00 EDT 2012
Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering.
International journal of nanomedicine
Ziv-Polat O,Skaat H,Shahar A,Margel S
Tue Jun 19 00:00:00 EDT 2012
Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism.
PloS one
Killian RL,Flippin JD,Herrera CM,Almenar-Queralt A,Goldstein LS
Mon Jun 11 00:00:00 EDT 2012
Efficient derivation of multipotent neural stem/progenitor cells from non-human primate embryonic stem cells.
PloS one
Shimada H,Okada Y,Ibata K,Ebise H,Ota S,Tomioka I,Nomura T,Maeda T,Kohda K,Yuzaki M,Sasaki E,Nakamura M,Okano H
Mon May 06 00:00:00 EDT 2013
Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes.
PloS one
Kim DS,Lee DR,Kim HS,Yoo JE,Jung SJ,Lim BY,Jang J,Kang HC,You S,Hwang DY,Leem JW,Nam TS,Cho SR,Kim DW
Fri Apr 19 00:00:00 EDT 2013
Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma.
Molecular systems biology
Setty M,Helmy K,Khan AA,Silber J,Arvey A,Neezen F,Agius P,Huse JT,Holland EC,Leslie CS
Mon Jan 14 00:00:00 EST 2013
Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons.
PloS one
Park TI,Monzo H,Mee EW,Bergin PS,Teoh HH,Montgomery JM,Faull RL,Curtis MA,Dragunow M
Thu Oct 11 00:00:00 EDT 2012
Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions.
PloS one
Frank S,Zhang M,Schöler HR,Greber B
Mon Jan 14 00:00:00 EST 2013
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
PloS one
Ring H,Mendu SK,Shirazi-Fard S,Birnir B,Hallböök F
Wed Sep 19 00:00:00 EDT 2012
Functional neuronal cells generated by human parthenogenetic stem cells.
PloS one
Ahmad R,Wolber W,Eckardt S,Koch P,Schmitt J,Semechkin R,Geis C,Heckmann M,Brüstle O,McLaughlin JK,Sirén AL,Müller AM
Thu Jan 10 00:00:00 EST 2013
A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
The Journal of biological chemistry
Hayashi H,Eguchi Y,Fukuchi-Nakaishi Y,Takeya M,Nakagata N,Tanaka K,Vance JE,Tanihara H
Fri Jul 20 00:00:00 EDT 2012
Perivascular-like cells contribute to the stability of the vascular network of osteogenic tissue formed from cell sheet-based constructs.
PloS one
Mendes LF,Pirraco RP,Szymczyk W,Frias AM,Santos TC,Reis RL,Marques AP
Fri Dec 07 00:00:00 EST 2012
Self-renewal and pluripotency acquired through somatic reprogramming to human cancer stem cells.
PloS one
Nagata S,Hirano K,Kanemori M,Sun LT,Tada T
Thu May 09 00:00:00 EDT 2013
Self-renewal and pluripotency acquired through somatic reprogramming to human cancer stem cells.
PloS one
Nagata S,Hirano K,Kanemori M,Sun LT,Tada T
Thu May 09 00:00:00 EDT 2013
Stem cell therapy: social recognition recovery in a FASD model.
Translational psychiatry
Shirasaka T,Hashimoto E,Ukai W,Yoshinaga T,Ishii T,Tateno M,Saito T
Tue Nov 13 00:00:00 EST 2012
miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma.
BMC cancer
Põlajeva J,Swartling FJ,Jiang Y,Singh U,Pietras K,Uhrbom L,Westermark B,Roswall P
Wed Aug 29 00:00:00 EDT 2012
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
PloS one
Muto J,Imai T,Ogawa D,Nishimoto Y,Okada Y,Mabuchi Y,Kawase T,Iwanami A,Mischel PS,Saya H,Yoshida K,Matsuzaki Y,Okano H
Mon Aug 20 00:00:00 EDT 2012
Radiation-Triggered NF-κB Activation is Responsible for the Angiogenic Signaling Pathway and Neovascularization for Breast Cancer Cell Proliferation and Growth.
Breast cancer : basic and clinical research
Yu H,Mohan S,Natarajan M
Thu Aug 23 00:00:00 EDT 2012
Gene expression profile of adult human olfactory bulb and embryonic neural stem cell suggests distinct signaling pathways and epigenetic control.
PloS one
Marei HE,Ahmed AE,Michetti F,Pescatori M,Pallini R,Casalbore P,Cenciarelli C,Elhadidy M
Fri Jul 27 00:00:00 EDT 2012
Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors.
Nature communications
Blauwkamp TA,Nigam S,Ardehali R,Weissman IL,Nusse R
Fri Feb 01 00:00:00 EST 2013
Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid.
The Journal of biological chemistry
Ono S,Hane M,Kitajima K,Sato C
Fri Feb 03 00:00:00 EST 2012
Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN.
PloS one
Han M,Liu M,Wang Y,Chen X,Xu J,Sun Y,Zhao L,Qu H,Fan Y,Wu C
Thu Mar 21 00:00:00 EDT 2013
Cryopreservation of human vascular umbilical cord cells under good manufacturing practice conditions for future cell banks.
Journal of translational medicine
Polchow B,Kebbel K,Schmiedeknecht G,Reichardt A,Henrich W,Hetzer R,Lueders C
Wed May 16 00:00:00 EDT 2012
miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis.
PloS one
Silber J,Jacobsen A,Ozawa T,Harinath G,Pedraza A,Sander C,Holland EC,Huse JT
Mon Nov 19 00:00:00 EST 2012
Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
PloS one
Lin SP,Lee YT,Wang JY,Miller SA,Chiou SH,Hung MC,Hung SC
Wed May 22 00:00:00 EDT 2013
Nuclear translocation of β-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype.
PloS one
Herencia C,Martínez-Moreno JM,Herrera C,Corrales F,Santiago-Mora R,Espejo I,Barco M,Almadén Y,de la Mata M,Rodríguez-Ariza A,Muñoz-Castañeda JR
Wed Oct 17 00:00:00 EDT 2012
Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy.
PloS one
Hensel N,Ratzka A,Brinkmann H,Klimaschewski L,Grothe C,Claus P
Tue Jul 31 00:00:00 EDT 2012
Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2.
The Journal of biological chemistry
Wang YN,Lee HH,Lee HJ,Du Y,Yamaguchi H,Hung MC
Fri May 11 00:00:00 EDT 2012
Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling.
PloS one
Torres J,Prieto J,Durupt FC,Broad S,Watt FM
Tue Sep 04 00:00:00 EDT 2012
S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.
PloS one
Lacar B,Herman P,Hartman NW,Hyder F,Bordey A
Fri Aug 03 00:00:00 EDT 2012
Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.
PloS one
Zhu R,Yang Y,Tian Y,Bai J,Zhang X,Li X,Peng Z,He Y,Chen L,Pan Q,Fang D,Chen W,Qian C,Bian X,Wang R
Mon Aug 27 00:00:00 EDT 2012
NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.
Nature methods
Elliott DA,Braam SR,Koutsis K,Ng ES,Jenny R,Lagerqvist EL,Biben C,Hatzistavrou T,Hirst CE,Yu QC,Skelton RJ,Ward-van Oostwaard D,Lim SM,Khammy O,Li X,Hawes SM,Davis RP,Goulburn AL,Passier R,Prall OW,Haynes JM,Pouton CW,Kaye DM,Mummery CL,Elefanty AG,Stanley EG
Sun Oct 23 00:00:00 EDT 2011
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor.
Molecular psychiatry
Anacker C,Zunszain PA,Cattaneo A,Carvalho LA,Garabedian MJ,Thuret S,Price J,Pariante CM
Fri Jul 01 00:00:00 EDT 2011
Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Chu H,Gao J,Chen CW,Huard J,Wang Y
Tue Aug 16 00:00:00 EDT 2011
Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America
Agemy L,Friedmann-Morvinski D,Kotamraju VR,Roth L,Sugahara KN,Girard OM,Mattrey RF,Verma IM,Ruoslahti E
Tue Oct 18 00:00:00 EDT 2011
Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Papadeas ST,Kraig SE,O'Banion C,Lepore AC,Maragakis NJ
Tue Oct 25 00:00:00 EDT 2011
MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis.
Stem cells (Dayton, Ohio)
Sato A,Sunayama J,Matsuda K,Seino S,Suzuki K,Watanabe E,Tachibana K,Tomiyama A,Kayama T,Kitanaka C
Thu Dec 01 00:00:00 EST 2011
Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment.
Stem cells (Dayton, Ohio)
Meyer JS,Howden SE,Wallace KA,Verhoeven AD,Wright LS,Capowski EE,Pinilla I,Martin JM,Tian S,Stewart R,Pattnaik B,Thomson JA,Gamm DM
Mon Aug 01 00:00:00 EDT 2011
PBX1: a novel stage-specific regulator of adipocyte development.
Stem cells (Dayton, Ohio)
Monteiro MC,Sanyal M,Cleary ML,Sengenès C,Bouloumié A,Dani C,Billon N
Tue Nov 01 00:00:00 EDT 2011
Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Alva JA,Lee GE,Escobar EE,Pyle AD
Thu Dec 01 00:00:00 EST 2011
Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells.
Stem cells (Dayton, Ohio)
Iacovino M,Bosnakovski D,Fey H,Rux D,Bajwa G,Mahen E,Mitanoska A,Xu Z,Kyba M
Sat Oct 01 00:00:00 EDT 2011
Debrided skin as a source of autologous stem cells for wound repair.
Stem cells (Dayton, Ohio)
Natesan S,Wrice NL,Baer DG,Christy RJ
Mon Aug 01 00:00:00 EDT 2011
Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.
PloS one
Lepore AC,O'Donnell J,Kim AS,Williams T,Tuteja A,Rao MS,Kelley LL,Campanelli JT,Maragakis NJ
Mon Feb 13 00:00:00 EST 2012
Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord.
BMC neuroscience
Mamaeva D,Ripoll C,Bony C,Teigell M,Perrin FE,Rothhut B,Bieche I,Lidereau R,Privat A,Rigau V,Guillon H,Vachiery-Lahaye F,Noel D,Bauchet L,Hugnot JP
Mon Oct 10 00:00:00 EDT 2011
An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.
PloS one
Gil-Ranedo J,Mendiburu-Eliçabe M,García-Villanueva M,Medina D,del Álamo M,Izquierdo M
Mon Apr 23 00:00:00 EDT 2012
Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.
Oncotarget
Weber GL,Parat MO,Binder ZA,Gallia GL,Riggins GJ
Tue Nov 01 00:00:00 EDT 2011
Differentiation of mesenchymal stem cells derived from pancreatic islets and bone marrow into islet-like cell phenotype.
PloS one
Zanini C,Bruno S,Mandili G,Baci D,Cerutti F,Cenacchi G,Izzi L,Camussi G,Forni M
Mon Aug 27 00:00:00 EDT 2012
Human cardiac stem cells isolated from atrial appendages stably express c-kit.
PloS one
He JQ,Vu DM,Hunt G,Chugh A,Bhatnagar A,Bolli R
Mon Apr 09 00:00:00 EDT 2012
In vitro model of vascularized bone: synergizing vascular development and osteogenesis.
PloS one
Correia C,Grayson WL,Park M,Hutton D,Zhou B,Guo XE,Niklason L,Sousa RA,Reis RL,Vunjak-Novakovic G
Fri Jul 20 00:00:00 EDT 2012
Human cardiac-derived adherent proliferating cells reduce murine acute Coxsackievirus B3-induced myocarditis.
PloS one
Miteva K,Haag M,Peng J,Savvatis K,Becher PM,Seifert M,Warstat K,Westermann D,Ringe J,Sittinger M,Schultheiss HP,Tschöpe C,Van Linthout S
Mon Apr 23 00:00:00 EDT 2012
Efficient derivation of human neuronal progenitors and neurons from pluripotent human embryonic stem cells with small molecule induction.
Journal of visualized experiments : JoVE
Parsons XH,Teng YD,Parsons JF,Snyder EY,Smotrich DB,Moore DA
Fri Oct 28 00:00:00 EDT 2011
A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40.
The Journal of biological chemistry
Singh SK,Bhardwaj R,Wilczynska KM,Dumur CI,Kordula T
Fri Nov 18 00:00:00 EST 2011
Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) protein regulates osteoblast differentiation.
The Journal of biological chemistry
Nam HK,Liu J,Li Y,Kragor A,Hatch NE
Fri Nov 11 00:00:00 EST 2011
In vivo tracking of human neural stem cells with 19F magnetic resonance imaging.
PloS one
Boehm-Sturm P,Mengler L,Wecker S,Hoehn M,Kallur T
Mon May 21 00:00:00 EDT 2012
CREB is activated by muscle injury and promotes muscle regeneration.
PloS one
Stewart R,Flechner L,Montminy M,Berdeaux R
Tue Feb 28 00:00:00 EST 2012
Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein.
The Journal of biological chemistry
Ikushima H,Todo T,Ino Y,Takahashi M,Saito N,Miyazawa K,Miyazono K
Fri Dec 02 00:00:00 EST 2011
Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model.
Stem cell research & therapy
Watts AE,Yeager AE,Kopyov OV,Nixon AJ
Thu Jan 27 00:00:00 EST 2011
Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene.
PLoS genetics
Snider L,Geng LN,Lemmers RJ,Kyba M,Ware CB,Nelson AM,Tawil R,Filippova GN,van der Maarel SM,Tapscott SJ,Miller DG
Thu Oct 28 00:00:00 EDT 2010
EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal stem cells.
BMC molecular biology
Curtis KM,Gomez LA,Rios C,Garbayo E,Raval AP,Perez-Pinzon MA,Schiller PC
Tue Aug 17 00:00:00 EDT 2010
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.
Cell research
Song Z,Cai J,Liu Y,Zhao D,Yong J,Duo S,Song X,Guo Y,Zhao Y,Qin H,Yin X,Wu C,Che J,Lu S,Ding M,Deng H
Sun Nov 01 00:00:00 EDT 2009
