Product References
Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation.
Cellular and molecular life sciences : CMLS
Huis In 't Veld LGM,Ho NI,Wassink M,den Brok MH,Adema GJ
AF-300-19 was used in In vitro experiments to show that SBAs specifically induce the PKR-like Endoplasmic Reticulum kinase (PERK) pathway and that SBA-induced DC cross-presentation is dependent on activation of the PERK pathway.
Sat Apr 09 00:00:00 EDT 2022
Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.
Stem cells translational medicine
Trump LR,Nayak RC,Singh AK,Emberesh S,Wellendorf AM,Lutzko CM,Cancelas JA
Sat Jun 01 00:00:00 EDT 2019
Gene correction for SCID-X1 in long-term hematopoietic stem cells.
Nature communications
Pavel-Dinu M,Wiebking V,Dejene BT,Srifa W,Mantri S,Nicolas CE,Lee C,Bao G,Kildebeck EJ,Punjya N,Sindhu C,Inlay MA,Saxena N,DeRavin SS,Malech H,Roncarolo MG,Weinberg KI,Porteus MH
Tue Apr 09 00:00:00 EDT 2019
Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells.
Scientific reports
Song L,Yuan X,Jones Z,Vied C,Miao Y,Marzano M,Hua T,Sang QA,Guan J,Ma T,Zhou Y,Li Y
Tue Jul 30 00:00:00 EDT 2019
TAF1 plays a critical role in AML1-ETO driven leukemogenesis.
Nature communications
Xu Y,Man N,Karl D,Martinez C,Liu F,Sun J,Martinez CJ,Martin GM,Beckedorff F,Lai F,Yue J,Roisman A,Greenblatt S,Duffort S,Wang L,Sun X,Figueroa M,Shiekhattar R,Nimer S
Tue Oct 29 00:00:00 EDT 2019
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Nature communications
Minuesa G,Albanese SK,Xie W,Kazansky Y,Worroll D,Chow A,Schurer A,Park SM,Rotsides CZ,Taggart J,Rizzi A,Naden LN,Chou T,Gourkanti S,Cappel D,Passarelli MC,Fairchild L,Adura C,Glickman JF,Schulman J,Famulare C,Patel M,Eibl JK,Ross GM,Bhattacharya S,Tan DS,Leslie CS,Beuming T,Patel DJ,Goldgur Y,Chodera JD,Kharas MG
Wed Jun 19 00:00:00 EDT 2019
Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.
Stem cell reports
Easterbrook J,Rybtsov S,Gordon-Keylock S,Ivanovs A,Taoudi S,Anderson RA,Medvinsky A
Tue May 14 00:00:00 EDT 2019
Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing.
Nature communications
McGrath E,Shin H,Zhang L,Phue JN,Wu WW,Shen RF,Jang YY,Revollo J,Ye Z
Mon Nov 25 00:00:00 EST 2019
Ex Vivo Expansion of CD34+ CD90+ CD49f+ Hematopoietic Stem and Progenitor Cells from Non-Enriched Umbilical Cord Blood with Azole Compounds.
Stem cells translational medicine
Bari S,Zhong Q,Fan X,Poon Z,Lim AST,Lim TH,Dighe N,Li S,Chiu GNC,Chai CLL,Hwang WYK
Tue May 01 00:00:00 EDT 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 EDT 2018
Gene therapy for Wiskott-Aldrich syndrome in a severely affected adult.
Blood
Morris EC,Fox T,Chakraverty R,Tendeiro R,Snell K,Rivat C,Grace S,Gilmour K,Workman S,Buckland K,Butler K,Chee R,Salama AD,Ibrahim H,Hara H,Duret C,Mavilio F,Male F,Bushman FD,Galy A,Burns SO,Gaspar HB,Thrasher AJ
Thu Sep 14 00:00:00 EDT 2017
Engraftment and in vivo proliferation advantage of gene-corrected mobilized CD34+ cells from Fanconi anemia patients.
Blood
Río P,Navarro S,Guenechea G,Sánchez-Domínguez R,Lamana ML,Yañez R,Casado JA,Mehta PA,Pujol MR,Surrallés J,Charrier S,Galy A,Segovia JC,Díaz de Heredia C,Sevilla J,Bueren JA
Thu Sep 28 00:00:00 EDT 2017
Notch-Expanded Murine Hematopoietic Stem and Progenitor Cells Mitigate Death from Lethal Radiation and Convey Immune Tolerance in Mismatched Recipients.
Stem cells translational medicine
Milano F,Merriam F,Nicoud I,Li J,Gooley TA,Heimfeld S,Imren S,Delaney C
Wed Feb 01 00:00:00 EST 2017
Identification of novel genes and networks governing hematopoietic stem cell development.
EMBO reports
Han T,Yang CS,Chang KY,Zhang D,Imam FB,Rana TM
Thu Dec 01 00:00:00 EST 2016
Generation and Characterization of Patient-Specific Induced Pluripotent Stem Cell for Disease Modeling.
Methods in molecular biology (Clifton, N.J.)
Sivapatham R,Zeng X
AF-300-19 was used in Cell Culture to describe the generation and characterization of iPSC from blood or fibroblast on a routine base and focus on the integration-free methodologies.
Thu Aug 18 00:00:00 EDT 2016
A Newly Defined and Xeno-Free Culture Medium Supports Every-Other-Day Medium Replacement in the Generation and Long-Term Cultivation of Human Pluripotent Stem Cells.
PloS one
Ahmadian Baghbaderani B,Tian X,Scotty Cadet J,Shah K,Walde A,Tran H,Kovarcik DP,Clarke D,Fellner T
AF-300-19 was used in Cell Culture to show that the medium plays an integral role in establishing a cGMP-compliant process for the manufacturing of hiPSCs that can be used for generation of clinically relevant cell types for cell replacement therapy applications.
Fri Aug 04 00:00:00 EDT 2017
USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.
Stem cell reports
Higuchi M,Kawamura H,Matsuki H,Hara T,Takahashi M,Saito S,Saito K,Jiang S,Naito M,Kiyonari H,Fujii M
Tue Dec 13 00:00:00 EST 2016
Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.
The Journal of clinical investigation
Nayak RC,Trump LR,Aronow BJ,Myers K,Mehta P,Kalfa T,Wellendorf AM,Valencia CA,Paddison PJ,Horwitz MS,Grimes HL,Lutzko C,Cancelas JA
Mon Aug 03 00:00:00 EDT 2015
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Blood
Klco JM,Spencer DH,Lamprecht TL,Sarkaria SM,Wylie T,Magrini V,Hundal J,Walker J,Varghese N,Erdmann-Gilmore P,Lichti CF,Meyer MR,Townsend RR,Wilson RK,Mardis ER,Ley TJ
Thu Feb 28 00:00:00 EST 2013
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.
Molecular therapy : the journal of the American Society of Gene Therapy
Scaramuzza S,Biasco L,Ripamonti A,Castiello MC,Loperfido M,Draghici E,Hernandez RJ,Benedicenti F,Radrizzani M,Salomoni M,Ranzani M,Bartholomae CC,Vicenzi E,Finocchi A,Bredius R,Bosticardo M,Schmidt M,von Kalle C,Montini E,Biffi A,Roncarolo MG,Naldini L,Villa A,Aiuti A
Tue Jan 01 00:00:00 EST 2013
IGF-1 promotes the development and cytotoxic activity of human NK cells.
Nature communications
Ni F,Sun R,Fu B,Wang F,Guo C,Tian Z,Wei H
Thu Jun 20 00:00:00 EDT 2013
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Cell
Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA
Fri Jun 08 00:00:00 EDT 2012
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
Nature methods
Certo MT,Gwiazda KS,Kuhar R,Sather B,Curinga G,Mandt T,Brault M,Lambert AR,Baxter SK,Jacoby K,Ryu BY,Kiem HP,Gouble A,Paques F,Rawlings DJ,Scharenberg AM
Mon Oct 01 00:00:00 EDT 2012
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.
Blood
Wong GW,Knowles GC,Mak TW,Ferrando AA,Zúñiga-Pflücker JC
Thu Aug 16 00:00:00 EDT 2012
FANCL ubiquitinates β-catenin and enhances its nuclear function.
Blood
Dao KH,Rotelli MD,Petersen CL,Kaech S,Nelson WD,Yates JE,Hanlon Newell AE,Olson SB,Druker BJ,Bagby GC
Thu Jul 12 00:00:00 EDT 2012
RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.
Blood
Baudet A,Karlsson C,Safaee Talkhoncheh M,Galeev R,Magnusson M,Larsson J
Thu Jun 28 00:00:00 EDT 2012
Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.
Blood
Williams AB,Li L,Nguyen B,Brown P,Levis M,Small D
Thu Oct 11 00:00:00 EDT 2012
Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.
Blood
Williams AB,Li L,Nguyen B,Brown P,Levis M,Small D
Thu Oct 11 00:00:00 EDT 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 EDT 2012
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.
Proceedings of the National Academy of Sciences of the United States of America
Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I
Tue Oct 23 00:00:00 EDT 2012
Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion.
Cytotherapy
Chu PP,Bari S,Fan X,Gay FP,Ang JM,Chiu GN,Lim SK,Hwang WY
Mon Oct 01 00:00:00 EDT 2012
Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice.
Stem cells (Dayton, Ohio)
Reimann C,Six E,Dal-Cortivo L,Schiavo A,Appourchaux K,Lagresle-Peyrou C,de Chappedelaine C,Ternaux B,Coulombel L,Beldjord K,Cavazzana-Calvo M,Andre-Schmutz I
Wed Aug 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression.
Journal of immunology (Baltimore, Md. : 1950)
Volpi C,Fallarino F,Bianchi R,Orabona C,De Luca A,Vacca C,Romani L,Gran B,Grohmann U,Puccetti P,Belladonna ML
Sat Sep 01 00:00:00 EDT 2012
Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.
Cell communication and signaling : CCS
Arora D,Köthe S,van den Eijnden M,Hooft van Huijsduijnen R,Heidel F,Fischer T,Scholl S,Tölle B,Böhmer SA,Lennartsson J,Isken F,Müller-Tidow C,Böhmer FD
Wed Jul 11 00:00:00 EDT 2012
Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities.
PloS one
Aggarwal R,Lu J,Kanji S,Joseph M,Das M,Noble GJ,McMichael BK,Agarwal S,Hart RT,Sun Z,Lee BS,Rosol TJ,Jackson R,Mao HQ,Pompili VJ,Das H
Wed Dec 12 00:00:00 EST 2012
Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.
PloS one
Danova-Alt R,Heider A,Egger D,Cross M,Alt R
Tue Aug 07 00:00:00 EDT 2012
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
PloS one
Pelosi E,Castelli G,Martin-Padura I,Bordoni V,Santoro S,Conigliaro A,Cerio AM,De Santis Puzzonia M,Marighetti P,Biffoni M,Alonzi T,Amicone L,Alcalay M,Bertolini F,Testa U,Tripodi M
Tue May 21 00:00:00 EDT 2013
Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors.
PloS one
Ramos-Mejía V,Montes R,Bueno C,Ayllón V,Real PJ,Rodríguez R,Menendez P
Mon Aug 27 00:00:00 EDT 2012
Inhibition of Mammalian target of rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress.
Bone marrow research
Ryningen A,Reikvam H,Nepstad I,Paulsen Rye K,Bruserud O
Mon Oct 22 00:00:00 EDT 2012
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.
BMC immunology
Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ
Thu Aug 16 00:00:00 EDT 2012
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.
BMC immunology
Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ
Thu Aug 16 00:00:00 EDT 2012
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.
The Journal of biological chemistry
Yang T,Jian W,Luo Y,Fu X,Noguchi C,Bungert J,Huang S,Qiu Y
Fri Nov 23 00:00:00 EST 2012
Direct chromatin PCR (DC-PCR): hypotonic conditions allow differentiation of chromatin states during thermal cycling.
PloS one
Vatolin S,Khan SN,Reu FJ
Tue Mar 12 00:00:00 EDT 2013
Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion.
PloS one
Sangeetha VM,Kadekar D,Kale VP,Limaye LS
Mon May 14 00:00:00 EDT 2012
Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.
The Journal of biological chemistry
Gao H,Wu X,Sun Y,Zhou S,Silberstein LE,Zhu Z
Fri Aug 24 00:00:00 EDT 2012
Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.
PloS one
Li XH,Ha CT,Fu D,Xiao M
Thu May 09 00:00:00 EDT 2013
A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo.
PloS one
Dahlke C,Maul K,Christalla T,Walz N,Schult P,Stocking C,Grundhoff A
Wed May 22 00:00:00 EDT 2013
Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.
PloS one
Yamagata Y,Parietti V,Stockholm D,Corre G,Poinsignon C,Touleimat N,Delafoy D,Besse C,Tost J,Galy A,Paldi A
Wed Jul 24 00:00:00 EDT 2013
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 EDT 2011
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Blood
Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE
Thu Sep 29 00:00:00 EDT 2011
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
Blood
Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ
Thu Sep 01 00:00:00 EDT 2011
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow.
Blood
Matthes T,Dunand-Sauthier I,Santiago-Raber ML,Krause KH,Donze O,Passweg J,McKee T,Huard B
Thu Aug 18 00:00:00 EDT 2011
Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.
PloS one
Sjeklocha LM,Park CW,Wong PY,Roney MJ,Belcher JD,Kaufman DS,Vercellotti GM,Hebbel RP,Steer CJ
Mon May 21 00:00:00 EDT 2012
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.
Blood cancer journal
Skavland J,Jørgensen KM,Hadziavdic K,Hovland R,Jonassen I,Bruserud O,Gjertsen BT
Tue Feb 01 00:00:00 EST 2011
Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
The Journal of biological chemistry
Sarma NJ,Yaseen NR
Fri Nov 11 00:00:00 EST 2011
Magnetic resonance imaging of bone marrow cell-mediated interleukin-10 gene therapy of atherosclerosis.
PloS one
Sun J,Li X,Feng H,Gu H,Blair T,Li J,Soriano S,Meng Y,Zhang F,Feng Q,Yang X
Tue Feb 14 00:00:00 EST 2012
Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase.
PloS one
Nishino T,Wang C,Mochizuki-Kashio M,Osawa M,Nakauchi H,Iwama A
Mon Jan 30 00:00:00 EST 2012
