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Product Details
BMS324
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Not Applicable
Expression System
E. coli
Amino acid sequence
Human GM-CSF recombinant protein consists of 127 amino acids
Molecular weight
14.5 kDa
Class
Recombinant
Type
Protein
Purity
>98%
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
2mM sodium phosphate, pH 7.4
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Description: Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a potent species-specific stimulator of bone marrow cells. GM-CSF is produced by a number of different cell types in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils. Human recombinant GM-CSF is a 14.5 kDa protein containing 127 amino acid residues.
Purity: >98%.
Molecular Weight: 14.5 kDa.
Target Information
The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; GM-CSF; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; Granulocyte-macrophage colony-stimulating factor; M-GM-CSF; MGC131935; MGC138897; MGC151255; MGC151257; Molgramostin; Sargramostim
Gene Aliases: CSF2; GMCSF
UniProt ID: (Human) P04141
Entrez Gene ID: (Human) 1437
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