Gibco

Human GRO-gamma (CXCL3) Recombinant Protein, PeproTech®

Human GRO-gamma (CXCL3) Protein in Functional Assay (Functional)

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Human GRO-gamma (CXCL3) Protein (300-40-10UG) in Functional

Bioassay analysis of Human GRO-gamma (CXCL3) Recombinant Protein, PeproTech® (Product # 300-40-1MG).

Product Image Gallery

Product Details

300-40-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 18 publications 18 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Bacteria, Hamster, Human, Mouse, Protozoa

Expression System

E. coli

Amino acid sequence

ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN

Molecular weight

7.9 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human GRO-gamma is a 7.9 kDa protein consisting of 73 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

CXCL3 may play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.

The Journal of biological chemistry

Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S

Fri Jul 19 00:00:00 EDT 2019

Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.

Virulence

Liu J,Ma'ayeh S,Peirasmaki D,Lundström-Stadelmann B,Hellman L,Svärd SG

300-40 was used in In vitro experiments to characterise the role of the three main cysteine proteases secreted by Giardia intestinalis in the development of Giardiasis.

Mon Dec 31 00:00:00 EST 2018

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.

Scientific reports

Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S

Fri Apr 20 00:00:00 EDT 2018

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Scientific reports

Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S

Tue Jun 27 00:00:00 EDT 2017

NAP-2 Secreted by Human NK Cells Can Stimulate Mesenchymal Stem/Stromal Cell Recruitment.

Stem cell reports

Almeida CR,Caires HR,Vasconcelos DP,Barbosa MA

Tue Apr 12 00:00:00 EDT 2016

A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.

Cancer cell

Su S,Liu Q,Chen J,Chen J,Chen F,He C,Huang D,Wu W,Lin L,Huang W,Zhang J,Cui X,Zheng F,Li H,Yao H,Su F,Song E

Mon May 12 00:00:00 EDT 2014

Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines.

Journal of immunology (Baltimore, Md. : 1950)

Chen HW,Chen HY,Wang LT,Wang FH,Fang LW,Lai HY,Chen HH,Lu J,Hung MS,Cheng Y,Chen MY,Liu SJ,Chong P,Lee OK,Hsu SC

Wed May 15 00:00:00 EDT 2013

Host chemokines bind to Staphylococcus aureus and stimulate protein A release.

The Journal of biological chemistry

Yung SC,Parenti D,Murphy PM

Fri Feb 18 00:00:00 EST 2011

Adenosine receptor A1 regulates polymorphonuclear cell trafficking and microvascular permeability in lipopolysaccharide-induced lung injury.

Journal of immunology (Baltimore, Md. : 1950)

Ngamsri KC,Wagner R,Vollmer I,Stark S,Reutershan J

Fri Oct 01 00:00:00 EDT 2010

The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist.

The Journal of biological chemistry

Lüttichau HR

Fri Mar 19 00:00:00 EDT 2010

Streptococcus agalactiae CspA is a serine protease that inactivates chemokines.

Journal of bacteriology

Bryan JD,Shelver DW

Sun Mar 01 00:00:00 EST 2009

SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.

PloS one

Egesten A,Olin AI,Linge HM,Yadav M,Mörgelin M,Karlsson A,Collin M

Mon Jun 15 00:00:00 EDT 2009

Modulation of keratinocyte-derived MMP-9 by IL-13: a possible role for the pathogenesis of epidermal inflammation.

The Journal of investigative dermatology

Purwar R,Kraus M,Werfel T,Wittmann M

Tue Jan 01 00:00:00 EST 2008

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS pathogens

Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM

Tue Jan 01 00:00:00 EST 2008

NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments.

Journal of immunology (Baltimore, Md. : 1950)

Pulai JI,Chen H,Im HJ,Kumar S,Hanning C,Hegde PS,Loeser RF

Sun May 01 00:00:00 EDT 2005

Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity.

Journal of immunology (Baltimore, Md. : 1950)

Carlos CA,Dong HF,Howard OM,Oppenheim JJ,Hanisch FG,Finn OJ

Mon Aug 01 00:00:00 EDT 2005

GRO family chemokines are specialized for monocyte arrest from flow.

American journal of physiology. Heart and circulatory physiology

Smith DF,Galkina E,Ley K,Huo Y

Tue Nov 01 00:00:00 EST 2005

Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Huang R,Lin Y,Shi Q,Flowers L,Ramachandran S,Horowitz IR,Parthasarathy S,Huang RP

Thu Jan 15 00:00:00 EST 2004

The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro.

Stem cells (Dayton, Ohio)

Majka M,Ratajczak J,Lee B,Honczarenko M,Douglas R,Kowalska MA,Silberstein L,Gewirtz AM,Ratajczak MZ

Mon Jun 26 00:00:00 EDT 2000

Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.

The Journal of experimental medicine

Tiffany HL,Lautens LL,Gao JL,Pease J,Locati M,Combadiere C,Modi W,Bonner TI,Murphy PM

Mon Jul 07 00:00:00 EDT 1997

Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.

The Journal of experimental medicine

Tiffany HL,Lautens LL,Gao JL,Pease J,Locati M,Combadiere C,Modi W,Bonner TI,Murphy PM

Mon Jul 07 00:00:00 EDT 1997

Bioinformatics

Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 3; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 3; CXC; CXC motif chemokine; CXCL; gro gamma; GRO-gamma; GRO-gamma(1-73); GRO3 oncogene; Growth-regulated protein gamma; Macrophage inflammatory protein 2-beta; melanoma growth stimulatory activity gamma; MGSA gamma; MIP2-beta

Human GRO-gamma (CXCL3) Recombinant Protein, PeproTech®

Human GRO-gamma (CXCL3) Protein (300-40-10UG) in Functional

Product Details

300-40-10UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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