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Product Details
PEP-071
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
purified
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-071 is a 15 amino acid synthetic peptide whose sequence corresponds to residues 415-428 of human HDAC 3 with an amino terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): C-D415-G-D-H-D-N-D-K-E-S-P-V-E-I428
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human HDAC 3, catalog # PA1-862. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 50 µL of distilled water for a concentration of 1 mg/mL.
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HD3; Histone deacetylase 3; Protein deacetylase HDAC3; Protein deacylase HDAC3; RPD3-2; SMAP45
Gene Aliases: HD3; HDAC3; RPD3; RPD3-2
UniProt ID: (Human) O15379
Entrez Gene ID: (Human) 8841
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