Product References
Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.
Hepatology (Baltimore, Md.)
Amarachintha SP,Mourya R,Ayabe H,Yang L,Luo Z,Li X,Thanekar U,Shivakumar P,Bezerra JA
Sat Jan 01 00:00:00 EST 2022
HGF Secreted by Mesenchymal Stromal Cells Promotes Primordial Follicle Activation by Increasing the Activity of the PI3K-AKT Signaling Pathway.
Stem cell reviews and reports
Mi X,Jiao W,Yang Y,Qin Y,Chen ZJ,Zhao S
100-39 was used in Tissue/organ culture to demonstrate that hUC-MSC-sec relies on HGF to enhance the signalling activity of PI3K-AKT pathway, promting the activation of primordial follicles; a therapeutic potential for POI patients.
Wed Jun 01 00:00:00 EDT 2022
Generation of Human Pluripotent Stem Cell-Derived Polarized Hepatocytes.
Current protocols
Bushweller L,Zhao Y,Zhang F,Wu X
100-39 was used in Cell Culture to describe protocols to generate hPSC-derived polarized HLCs (pol-HLCs), which feature clearly defined basolateral and apical membranes separated by tight junctions and to assay the pol-HLCs for basic hepatic functions and polarized hepatic characteristics.
Sat Jan 01 00:00:00 EST 2022
Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway.
Stem cell research & therapy
Wu H,Tang X,Wang Y,Wang N,Chen Q,Xie J,Liu S,Zhong Z,Qiu Y,Situ P,Zern MA,Wang J,Chen H,Duan Y
100-39 was used in Cell Culture to demonstrate a significant step toward developing the expansion of Human pluripotent stem cells (hPSCs) under 3D suspension condition in large-scale cultures. The study played an important role in controlling the size of hPSC aggregates in 3D suspension culture by inhibiting the expression of ICAM1 coupled with the down-regulation of E-cad through the activation of the Wnt signaling pathway.
Thu May 26 00:00:00 EDT 2022
Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.
Nature communications
Igarashi N,Miyata K,Loo TM,Chiba M,Hanyu A,Nishio M,Kawasaki H,Zheng H,Toyokuni S,Kon S,Moriyama K,Fujita Y,Takahashi A
100-39 was used in Competition Assay to provide evidence that cellular senescence inhibits cell competition-mediated elimination of oncogenic cells through HGF signaling, suggesting that it may lead to cancer incidence during aging.
Mon Jul 18 00:00:00 EDT 2022
Serum-Free Production of Three-Dimensional Hepatospheres from Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Rashidi H,Hay DC
100-39 was used in Cell Culture to describe a methodology to generate 3D hepatospheres from human pluripotent stem cells using defined and commercially available reagents.
Thu Jun 23 00:00:00 EDT 2022
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Nature communications
Belenguer G,Mastrogiovanni G,Pacini C,Hall Z,Dowbaj AM,Arnes-Benito R,Sljukic A,Prior N,Kakava S,Bradshaw CR,Davies S,Vacca M,Saeb-Parsy K,Koo BK,Huch M
Mon Jan 17 00:00:00 EST 2022
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease.
NPJ Regenerative medicine
Yun W,Choi KA,Hwang I,Zheng J,Park M,Hong W,Jang AY,Kim JH,Choi W,Kim DS,Kim IY,Kim YJ,Liu Y,Yoon BS,Park G,Song G,Hong S,You S
Thu Jan 13 00:00:00 EST 2022
Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation.
Cells
Raabe FJ,Stephan M,Waldeck JB,Huber V,Demetriou D,Kannaiyan N,Galinski S,Glaser LV,Wehr MC,Ziller MJ,Schmitt A,Falkai P,Rossner MJ
100-39 was used in In vitro experiments to highlight that TFs for generating iOPCs or iOLs should be chosen depending on the intended application or research question, and that SON might be beneficial to study more mature iOLs while S might be better suited to investigate iOPC biology.
Tue Jan 11 00:00:00 EST 2022
Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma.
Life science alliance
Capdeville C,Russo L,Penton D,Migliavacca J,Zecevic M,Gries A,Neuhauss SC,Grotzer MA,Baumgartner M
100-39 was used in In vitro experiments to investigate interactions between plasma membrane-associated proteome and medullablastoma.
Wed Jun 01 00:00:00 EDT 2022
Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation.
Scientific reports
Wang M,Silva T,Toothaker JM,McCourt BT,Shugrue C,Desir G,Gorelick F,Konnikova L
100-39 was used in Cell Culture to examine the potential role of renalase in placental development.
Wed Mar 23 00:00:00 EDT 2022
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens.
Cell stem cell
Karvas RM,Khan SA,Verma S,Yin Y,Kulkarni D,Dong C,Park KM,Chew B,Sane E,Fischer LA,Kumar D,Ma L,Boon ACM,Dietmann S,Mysorekar IU,Theunissen TW
100-39 was used in Cell Culture to demonstrate that SC-TOs exhibit selective vulnerability to emerging pathogens (SARS-CoV-2 and Zika virus), which correlates with expression levels of their respective entry factors.
Thu May 05 00:00:00 EDT 2022
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.
Cancer cell
Haag D,Mack N,Benites Goncalves da Silva P,Statz B,Clark J,Tanabe K,Sharma T,Jäger N,Jones DTW,Kawauchi D,Wernig M,Pfister SM
Mon Mar 08 00:00:00 EST 2021
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms.
Cancer cell
Hu H,Piotrowska Z,Hare PJ,Chen H,Mulvey HE,Mayfield A,Noeen S,Kattermann K,Greenberg M,Williams A,Riley AK,Wilson JJ,Mao YQ,Huang RP,Banwait MK,Ho J,Crowther GS,Hariri LP,Heist RS,Kodack DP,Pinello L,Shaw AT,Mino-Kenudson M,Hata AN,Sequist LV,Benes CH,Niederst MJ,Engelman JA
Mon Nov 08 00:00:00 EST 2021
Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.
Cell stem cell
Cordero-Espinoza L,Dowbaj AM,Kohler TN,Strauss B,Sarlidou O,Belenguer G,Pacini C,Martins NP,Dobie R,Wilson-Kanamori JR,Butler R,Prior N,Serup P,Jug F,Henderson NC,Hollfelder F,Huch M
Thu Nov 04 00:00:00 EDT 2021
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.
Cell stem cell
Shah PP,Lv W,Rhoades JH,Poleshko A,Abbey D,Caporizzo MA,Linares-Saldana R,Heffler JG,Sayed N,Thomas D,Wang Q,Stanton LJ,Bedi K,Morley MP,Cappola TP,Owens AT,Margulies KB,Frank DB,Wu JC,Rader DJ,Yang W,Prosser BL,Musunuru K,Jain R
100-39 was used in Cell Culture to show that pathogenic LAMIN A/C variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.
Thu May 06 00:00:00 EDT 2021
The biological process of lysine-tRNA charging is therapeutically targetable in liver cancer.
Liver international : official journal of the International Association for the Study of the Liver
Zhang R,Noordam L,Ou X,Ma B,Li Y,Das P,Shi S,Liu J,Wang L,Li P,Verstegen MMA,Reddy DS,van der Laan LJW,Peppelenbosch MP,Kwekkeboom J,Smits R,Pan Q
Fri Jan 01 00:00:00 EST 2021
Doxorubicin-induced senescence promotes stemness and tumorigenicity in EpCAM-/CD133- nonstem cell population in hepatocellular carcinoma cell line, HuH-7.
Molecular oncology
Karabicici M,Alptekin S,Fırtına Karagonlar Z,Erdal E
Sun Aug 01 00:00:00 EDT 2021
Characterization of primary models of human trophoblast.
Development (Cambridge, England)
Sheridan MA,Zhao X,Fernando RC,Gardner L,Perez-Garcia V,Li Q,Marsh SGE,Hamilton R,Moffett A,Turco MY
100-39 was used in Cell Culture to show that our results can be used to select the most suitable model for the study of trophoblast development, function and pathology.
Mon Nov 01 00:00:00 EDT 2021
CCAAT/enhancer-binding protein beta promotes muscle stem cell quiescence through regulation of quiescence-associated genes.
Stem cells (Dayton, Ohio)
Lala-Tabbert N,AlSudais H,Marchildon F,Fu D,Wiper-Bergeron N
Mon Mar 01 00:00:00 EST 2021
Stable Long-Term Culture of Human Distal Airway Stem Cells for Transplantation.
Stem cells international
Zhou Y,Wang Y,Li D,Zhang T,Ma Y,Zuo W
Wed Sep 29 00:00:00 EDT 2021
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
Nature communications
Nacke M,Sandilands E,Nikolatou K,Román-Fernández Á,Mason S,Patel R,Lilla S,Yelland T,Galbraith LCA,Freckmann EC,McGarry L,Morton JP,Shanks E,Leung HY,Markert E,Ismail S,Zanivan S,Blyth K,Bryant DM
Fri Mar 12 00:00:00 EST 2021
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
Nature communications
Nacke M,Sandilands E,Nikolatou K,Román-Fernández Á,Mason S,Patel R,Lilla S,Yelland T,Galbraith LCA,Freckmann EC,McGarry L,Morton JP,Shanks E,Leung HY,Markert E,Ismail S,Zanivan S,Blyth K,Bryant DM
Fri Mar 12 00:00:00 EST 2021
Protocol for establishing organoids from human ovarian cancer biopsies.
STAR protocols
Maenhoudt N,Vankelecom H
100-39 was used in Cell Culture to provide a detailed protocol for establishing organoid cultures from patient OC biopsies.
Fri Jun 18 00:00:00 EDT 2021
Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.
Cancer science
Khaledian B,Taguchi A,Shin-Ya K,Kondo-Ida L,Kagaya N,Suzuki M,Kajino T,Yamaguchi T,Shimada Y,Takahashi T
100-39 was used in In vitro experiments to indicate that HSP90 is required to sustain expression of ROR1 crucial for lung adenosarcoma survival, suggesting that inhibition of HSP90 could be a promising therapeutic strategy in ROR1-positive lung adenocarcinoma.
Mon Mar 01 00:00:00 EST 2021
Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis.
Odontology
Yamaguchi Y,Saito A,Horie M,Aoki A,Micke P,Ohshima M,Kappert K
100-39 was used in Cell Culture to highlight a potential role of HGF in periodontitis.
Fri Oct 01 00:00:00 EDT 2021
Thyroid Hormone Effect on the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells.
Pharmaceuticals (Basel, Switzerland)
Bogacheva MS,Bystriakova MA,Lou YR
100-39 was used in Sample Preparation (Western Blotting) to investigate hepatocyte-like cell culture from induced pluripotent stem cells for future therapeutic treatment.
Mon Jun 07 00:00:00 EDT 2021
Thyroid Hormone Effect on the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells.
Pharmaceuticals (Basel, Switzerland)
Bogacheva MS,Bystriakova MA,Lou YR
100-39 was used in Sample Preparation (Western Blotting) to investigate hepatocyte-like cell culture from induced pluripotent stem cells for future therapeutic treatment.
Mon Jun 07 00:00:00 EDT 2021
Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.
Scientific reports
Estrada A,Rodriguez AC,Rodriguez G,Grant AH,Ayala-Marin YM,Arrieta AJ,Kirken RA
Fri Aug 20 00:00:00 EDT 2021
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery.
Nature communications
Di Franco S,Bianca P,Sardina DS,Turdo A,Gaggianesi M,Veschi V,Nicotra A,Mangiapane LR,Lo Iacono M,Pillitteri I,van Hooff S,Martorana F,Motta G,Gulotta E,Lentini VL,Martorana E,Fiori ME,Vieni S,Bongiorno MR,Giannone G,Giuffrida D,Memeo L,Colarossi L,Mare M,Vigneri P,Todaro M,De Maria R,Medema JP,Stassi G
Wed Aug 18 00:00:00 EDT 2021
Protocol for automated production of human stem cell derived liver spheres.
STAR protocols
Meseguer-Ripolles J,Kasarinaite A,Lucendo-Villarin B,Hay DC
Fri Jun 18 00:00:00 EDT 2021
Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion.
Nature communications
Marco S,Neilson M,Moore M,Perez-Garcia A,Hall H,Mitchell L,Lilla S,Blanco GR,Hedley A,Zanivan S,Norman JC
Wed Nov 24 00:00:00 EST 2021
Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Lamballe F,Ahmad F,Vinik Y,Castellanet O,Daian F,Müller AK,Köhler UA,Bailly AL,Josselin E,Castellano R,Cayrou C,Charafe-Jauffret E,Mills GB,Géli V,Borg JP,Lev S,Maina F
Mon Feb 01 00:00:00 EST 2021
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure.
iScience
Meseguer-Ripolles J,Lucendo-Villarin B,Tucker C,Ferreira-Gonzalez S,Homer N,Wang Y,Starkey Lewis PJ,M Toledo E,Mellado-Gomez E,Simpson J,Flint O,Jaiswal H,Beer NL,Karlsen AE,Forbes SJ,Dear JW,Hughes J,Hay DC
Fri Jun 25 00:00:00 EDT 2021
Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes.
STAR protocols
Sinton MC,Meseguer-Ripolles J,Lucendo-Villarin B,Drake AJ,Hay DC
100-39 was used in Cell Culture to evaluate hepatocyte-like cell manufacturing from human pluripotent stem cells to study hepatic steatosis.
Fri Jun 18 00:00:00 EDT 2021
Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.
Communications biology
Nguyen L,Jager M,Lieshout R,de Ruiter PE,Locati MD,Besselink N,van der Roest B,Janssen R,Boymans S,de Jonge J,IJzermans JNM,Doukas M,Verstegen MMA,van Boxtel R,van der Laan LJW,Cuppen E,Kuijk E
Thu Nov 18 00:00:00 EST 2021
CODEX, a neural network approach to explore signaling dynamics landscapes.
Molecular systems biology
Jacques MA,Dobrzyński M,Gagliardi PA,Sznitman R,Pertz O
Thu Apr 01 00:00:00 EDT 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Nature communications
Tajan M,Hennequart M,Cheung EC,Zani F,Hock AK,Legrave N,Maddocks ODK,Ridgway RA,Athineos D,Suárez-Bonnet A,Ludwig RL,Novellasdemunt L,Angelis N,Li VSW,Vlachogiannis G,Valeri N,Mainolfi N,Suri V,Friedman A,Manfredi M,Blyth K,Sansom OJ,Vousden KH
100-39 was used in Tissue/organ culture to show that inhibition of PHGDH, the first step in the SSP, cooperates with serine and glycine depletion to inhibit one-carbon metabolism and cancer growth.
Thu Jan 14 00:00:00 EST 2021
Patient-derived xenografts and organoids model therapy response in prostate cancer.
Nature communications
Karkampouna S,La Manna F,Benjak A,Kiener M,De Menna M,Zoni E,Grosjean J,Klima I,Garofoli A,Bolis M,Vallerga A,Theurillat JP,De Filippo MR,Genitsch V,Keller D,Booij TH,Stirnimann CU,Eng K,Sboner A,Ng CKY,Piscuoglio S,Gray PC,Spahn M,Rubin MA,Thalmann GN,Kruithof-de Julio M
Thu Feb 18 00:00:00 EST 2021
Improved Models of Human Endometrial Organoids Based on Hydrogels from Decellularized Endometrium.
Journal of personalized medicine
Francés-Herrero E,Juárez-Barber E,Campo H,López-Martínez S,de Miguel-Gómez L,Faus A,Pellicer A,Ferrero H,Cervelló I
Thu Jun 03 00:00:00 EDT 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
Tue Jun 08 00:00:00 EDT 2021
An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.
Cell
Kawasaki K,Toshimitsu K,Matano M,Fujita M,Fujii M,Togasaki K,Ebisudani T,Shimokawa M,Takano A,Takahashi S,Ohta Y,Nanki K,Igarashi R,Ishimaru K,Ishida H,Sukawa Y,Sugimoto S,Saito Y,Maejima K,Sasagawa S,Lee H,Kim HG,Ha K,Hamamoto J,Fukunaga K,Maekawa A,Tanabe M,Ishihara S,Hamamoto Y,Yasuda H,Sekine S,Kudo A,Kitagawa Y,Kanai T,Nakagawa H,Sato T
Wed Nov 25 00:00:00 EST 2020
Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.
Cell
Yao M,Ventura PB,Jiang Y,Rodriguez FJ,Wang L,Perry JSA,Yang Y,Wahl K,Crittenden RB,Bennett ML,Qi L,Gong CC,Li XN,Barres BA,Bender TP,Ravichandran KS,Janes KA,Eberhart CG,Zong H
Thu Feb 06 00:00:00 EST 2020
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer.
Signal transduction and targeted therapy
Zheng Y,Wu C,Yang J,Zhao Y,Jia H,Xue M,Xu D,Yang F,Fu D,Wang C,Hu B,Zhang Z,Li T,Yan S,Wang X,Nelson PJ,Bruns C,Qin L,Dong Q
Wed May 13 00:00:00 EDT 2020
Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids.
Advanced healthcare materials
Krüger M,Oosterhoff LA,van Wolferen ME,Schiele SA,Walther A,Geijsen N,De Laporte L,van der Laan LJW,Kock LM,Spee B
Sun Mar 01 00:00:00 EST 2020
Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.
Cell systems
Gerosa L,Chidley C,Fröhlich F,Sanchez G,Lim SK,Muhlich J,Chen JY,Vallabhaneni S,Baker GJ,Schapiro D,Atanasova MI,Chylek LA,Shi T,Yi L,Nicora CD,Claas A,Ng TSC,Kohler RH,Lauffenburger DA,Weissleder R,Miller MA,Qian WJ,Wiley HS,Sorger PK
100-39 was used in Enzyme-linked immunosorbent assay to show that pulsatile MAPK activation by factors in the microenvironment generates a persistent population of melanoma cells that rewires MAPK signaling to sustain non-genetic drug resistance.
Wed Nov 18 00:00:00 EST 2020
Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia.
The Journal of cell biology
Zagryazhskaya-Masson A,Monteiro P,Macé AS,Castagnino A,Ferrari R,Infante E,Duperray-Susini A,Dingli F,Lanyi A,Loew D,Génot E,Chavrier P
Mon Sep 07 00:00:00 EDT 2020
cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer.
Stem cells (Dayton, Ohio)
He Y,Xiao M,Fu H,Chen L,Qi L,Liu D,Guo P,Chen L,Luo Y,Xiao H,Zhang N,Guo H
Wed Apr 01 00:00:00 EDT 2020
Live-cell screening platform using human-induced pluripotent stem cells expressing fluorescence-tagged cytochrome P450 1A1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kim JW,Im I,Kim H,Jeon JS,Kang EH,Jo S,Chun HS,Yoon S,Kim JH,Kim SK,Park HJ
Wed Jul 01 00:00:00 EDT 2020
Differential response to hepatic differentiation stimuli of amniotic epithelial cells isolated from four regions of the amniotic membrane.
Journal of cellular and molecular medicine
Passaretta F,Bosco D,Centurione L,Centurione MA,Marongiu F,Di Pietro R
Wed Apr 01 00:00:00 EDT 2020
Exosomes derived from chemically induced human hepatic progenitors inhibit oxidative stress induced cell death.
Biotechnology and bioengineering
Hyung S,Jeong J,Shin K,Kim JY,Yim JH,Yu CJ,Jung HS,Hwang KG,Choi D,Hong JW
Tue Sep 01 00:00:00 EDT 2020
Long-Term Expansion of Functional Human Pluripotent Stem Cell-Derived Hepatic Organoids.
International journal of stem cells
Mun SJ,Hong YH,Ahn HS,Ryu JS,Chung KS,Son MJ
100-39 was used in Cell Culture to test long-term prolonged culture of organoids to increase their maturity to demonstrate that organoids can be exponentially expanded by serial passaging, while maintaining long-term functional maturation potential, hence are a practical and renewable cell source for human cell-based and personalized 3D liver models.
Thu Jul 30 00:00:00 EDT 2020
Generation of multi-cellular human liver organoids from pluripotent stem cells.
Methods in cell biology
Thompson WL,Takebe T
100-39 was used in Cell Culture to demonstrate a protocol utilizing PSC derived 3D human liver organoids as a renewable, reproducible and personalized cell source, thus facilitating disease modeling and mechanistic studies.
Wed Jul 07 00:00:00 EDT 2021
Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives.
Scientific reports
Jo HY,Han HW,Jung I,Ju JH,Park SJ,Moon S,Geum D,Kim H,Park HJ,Kim S,Stacey GN,Koo SK,Park MH,Kim JH
Tue Mar 03 00:00:00 EST 2020
Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway.
Molecular systems biology
Gillies TE,Pargett M,Silva JM,Teragawa CK,McCormick F,Albeck JG
Thu Oct 01 00:00:00 EDT 2020
Stem cell-derived polarized hepatocytes.
Nature communications
Dao Thi VL,Wu X,Belote RL,Andreo U,Takacs CN,Fernandez JP,Vale-Silva LA,Prallet S,Decker CC,Fu RM,Qu B,Uryu K,Molina H,Saeed M,Steinmann E,Urban S,Singaraja RR,Schneider WM,Simon SM,Rice CM
Fri Apr 03 00:00:00 EDT 2020
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells.
Nature communications
Inada H,Udono M,Matsuda-Ito K,Horisawa K,Ohkawa Y,Miura S,Goya T,Yamamoto J,Nagasaki M,Ueno K,Saitou D,Suyama M,Maehara Y,Kumamaru W,Ogawa Y,Sekiya S,Suzuki A
Wed Oct 21 00:00:00 EDT 2020
Self-Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene.
Hepatology communications
Abbey D,Elwyn S,Hand NJ,Musunuru K,Rader DJ
Tue Sep 01 00:00:00 EDT 2020
The mutational impact of culturing human pluripotent and adult stem cells.
Nature communications
Kuijk E,Jager M,van der Roest B,Locati MD,Van Hoeck A,Korzelius J,Janssen R,Besselink N,Boymans S,van Boxtel R,Cuppen E
Tue May 19 00:00:00 EDT 2020
Mechano-modulatory synthetic niches for liver organoid derivation.
Nature communications
Sorrentino G,Rezakhani S,Yildiz E,Nuciforo S,Heim MH,Lutolf MP,Schoonjans K
Fri Jul 10 00:00:00 EDT 2020
Hepatocyte growth factor is upregulated in ischemic retina and contributes to retinal vascular leakage and neovascularization.
FASEB bioAdvances
Lorenc VE,Lima E Silva R,Hackett SF,Fortmann SD,Liu Y,Campochiaro PA
Wed Apr 01 00:00:00 EDT 2020
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.
Nature
Ramachandran P,Dobie R,Wilson-Kanamori JR,Dora EF,Henderson BEP,Luu NT,Portman JR,Matchett KP,Brice M,Marwick JA,Taylor RS,Efremova M,Vento-Tormo R,Carragher NO,Kendall TJ,Fallowfield JA,Harrison EM,Mole DJ,Wigmore SJ,Newsome PN,Weston CJ,Iredale JP,Tacke F,Pollard JW,Ponting CP,Marioni JC,Teichmann SA,Henderson NC
100-39 was used in In vitro experiments to investigate molecular definitions for non-parenchymal cell types in the healthy and cirrhotic human liver through transcriptomics.
Fri Nov 01 00:00:00 EDT 2019
Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens.
Cell research
Fu GB,Huang WJ,Zeng M,Zhou X,Wu HP,Liu CC,Wu H,Weng J,Zhang HD,Cai YC,Ashton C,Ding M,Tang D,Zhang BH,Gao Y,Yu WF,Zhai B,He ZY,Wang HY,Yan HX
Tue Jan 01 00:00:00 EST 2019
CXCR4 regulates Plasmodium development in mouse and human hepatocytes.
The Journal of experimental medicine
Bando H,Pradipta A,Iwanaga S,Okamoto T,Okuzaki D,Tanaka S,Vega-Rodríguez J,Lee Y,Ma JS,Sakaguchi N,Soga A,Fukumoto S,Sasai M,Matsuura Y,Yuda M,Jacobs-Lorena M,Yamamoto M
Mon Aug 05 00:00:00 EDT 2019
Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell-Derived Hepatocytes for Cell-Based Therapy.
Stem cells translational medicine
Blackford SJI,Ng SS,Segal JM,King AJF,Austin AL,Kent D,Moore J,Sheldon M,Ilic D,Dhawan A,Mitry RR,Rashid ST
Fri Feb 01 00:00:00 EST 2019
Hydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma.
Oncogenesis
Wu JR,You RI,Hu CT,Cheng CC,Rudy R,Wu WS
Tue Aug 06 00:00:00 EDT 2019
Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin.
Stem cells (Dayton, Ohio)
Shan J,Shen J,Wu M,Zhou H,Feng J,Yao C,Yang Z,Ma Q,Luo Y,Wang Y,Qian C
Fri Nov 01 00:00:00 EDT 2019
Identification of a Novel Bone Marrow Cell-Derived Accelerator of Fibrotic Liver Regeneration Through Mobilization of Hepatic Progenitor Cells in Mice.
Stem cells (Dayton, Ohio)
Yanagawa T,Sumiyoshi H,Higashi K,Nakao S,Higashiyama R,Fukumitsu H,Minakawa K,Chiba Y,Suzuki Y,Sumida K,Saito K,Kamiya A,Inagaki Y
Tue Jan 01 00:00:00 EST 2019
The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma.
Frontiers in oncology
Cheng F,Zhang P,Xiao Q,Li Y,Dong M,Wang H,Kuang D,He Y,Duan Q,Mao F,Wang B,Guo D
100-39 was used in Sample Preparation (Western Blotting) to study the expression of human leucine-rich repeats and immunoglobulin-like domains protein 3 (LRIG3) in human glioma specimens through immunohistochemical analysis to demonstrate that LRIG3 was weakly expressed in high-grade gliomas (WHO [World Health Organization] grades III and IV) compared with that in low-grade gliomas (WHO grade II).
Sat Nov 04 00:00:00 EDT 2023
TGFβ1 and HGF regulate CTGF expression in human atrial fibroblasts and are involved in atrial remodelling in patients with rheumatic heart disease.
Journal of cellular and molecular medicine
Chen JQ,Guo YS,Chen Q,Cheng XL,Xiang GJ,Chen MY,Wu HL,Huang QL,Zhu PL,Zhang JC
Mon Apr 01 00:00:00 EDT 2019
Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells.
Scientific reports
Pettinato G,Lehoux S,Ramanathan R,Salem MM,He LX,Muse O,Flaumenhaft R,Thompson MT,Rouse EA,Cummings RD,Wen X,Fisher RA
Thu Jun 20 00:00:00 EDT 2019
Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors.
The Journal of biological chemistry
Wei J,Ran G,Wang X,Jiang N,Liang J,Lin X,Ling C,Zhao B
Fri Sep 20 00:00:00 EDT 2019
Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects.
Cell reports
Ooi J,Langley SR,Xu X,Utami KH,Sim B,Huang Y,Harmston NP,Tay YL,Ziaei A,Zeng R,Low D,Aminkeng F,Sobota RM,Ginhoux F,Petretto E,Pouladi MA
100-39 was used in In vitro experiments to use genome editing to generate an allelic panel of isogenic Huntington disease (HD) (IsoHD) human embryonic stem cell (hESC) lines carrying varying CAG repeat lengths in the first exon of HTT.
Tue Feb 26 00:00:00 EST 2019
MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion.
Nature communications
Ferrari R,Martin G,Tagit O,Guichard A,Cambi A,Voituriez R,Vassilopoulos S,Chavrier P
Fri Oct 25 00:00:00 EDT 2019
The Differences in the Characteristics of Insulin-producing Cells Using Human Adipose-tissue Derived Mesenchymal Stem Cells from Subcutaneous and Visceral Tissues.
Scientific reports
Wada Y,Ikemoto T,Morine Y,Imura S,Saito Y,Yamada S,Shimada M
Fri Sep 13 00:00:00 EDT 2019
A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.
Scientific reports
Ohta S,Ikemoto T,Wada Y,Saito Y,Yamada S,Imura S,Morine Y,Shimada M
Tue Dec 10 00:00:00 EST 2019
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nature communications
Segal JM,Kent D,Wesche DJ,Ng SS,Serra M,Oulès B,Kar G,Emerton G,Blackford SJI,Darmanis S,Miquel R,Luong TV,Yamamoto R,Bonham A,Jassem W,Heaton N,Vigilante A,King A,Sancho R,Teichmann S,Quake SR,Nakauchi H,Rashid ST
Fri Jul 26 00:00:00 EDT 2019
A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhuang J,Zhang J,Wu M,Zhang Y
Fri Nov 01 00:00:00 EDT 2019
Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling.
Stem cell reports
Akbari S,Sevinç GG,Ersoy N,Basak O,Kaplan K,Sevinç K,Ozel E,Sengun B,Enustun E,Ozcimen B,Bagriyanik A,Arslan N,Önder TT,Erdal E
Tue Oct 08 00:00:00 EDT 2019
MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells.
Cell death & disease
Gailhouste L,Liew LC,Yasukawa K,Hatada I,Tanaka Y,Kato T,Nakagama H,Ochiya T
Thu Jul 18 00:00:00 EDT 2019
Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation.
iScience
Wang Y,Tatham MH,Schmidt-Heck W,Swann C,Singh-Dolt K,Meseguer-Ripolles J,Lucendo-Villarin B,Kunath T,Rudd TR,Smith AJH,Hengstler JG,Godoy P,Hay RT,Hay DC
100-39 was used in Cell Culture to demonstrate that nuclear HNF4α is essential for hepatic progenitor specification, and the introduction of point mutations in HNF4α's Small Ubiquitin-like Modifier consensus motif leads to disrupted hepatocyte differentiation.
Fri Jun 28 00:00:00 EDT 2019
Human Induced Pluripotent Stem Cell-Derived Definitive Endoderm Bulk Culture and Hepatic Differentiation.
Methods in molecular biology (Clifton, N.J.)
Palakkan AA,Nanda J,Ross JA
100-39 was used in In vitro experiments to develop a method to bulk culture definitive endoderm cells generated from human iPSCs which can be stored and differentiated to hepatocytes.
Thu Mar 12 00:00:00 EDT 2020
RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog.
Theranostics
Cao J,Zhao M,Liu J,Zhang X,Pei Y,Wang J,Yang X,Shen B,Zhang J
100-39 was used in Cell Culture to provide novel insights into the regulation of Nanog protein levels, as well the key role of RACK1 to enhance self-renewal and chemoresistance of CSCs in human HCC.
Tue Jan 14 00:00:00 EST 2020
Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer.
Cell death & disease
Zhang R,Qi F,Zhao F,Li G,Shao S,Zhang X,Yuan L,Feng Y
Wed Mar 20 00:00:00 EDT 2019
Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer.
Cell death & disease
Zhang R,Qi F,Zhao F,Li G,Shao S,Zhang X,Yuan L,Feng Y
Wed Mar 20 00:00:00 EDT 2019
SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation.
Nature communications
Kuroda T,Yasuda S,Tachi S,Matsuyama S,Kusakawa S,Tano K,Miura T,Matsuyama A,Sato Y
Wed May 15 00:00:00 EDT 2019
Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue.
Nature protocols
Tysoe OC,Justin AW,Brevini T,Chen SE,Mahbubani KT,Frank AK,Zedira H,Melum E,Saeb-Parsy K,Markaki AE,Vallier L,Sampaziotis F
100-39 was used in Cell Culture to conclude that COs provide a unique platform for studies in biliary physiology and pathophysiology, and the resulting bioengineered tissue has broad applications for regenerative medicine and cholangiopathies.
Sat Jun 01 00:00:00 EDT 2019
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown.
Cell
Chung H,Calis JJA,Wu X,Sun T,Yu Y,Sarbanes SL,Dao Thi VL,Shilvock AR,Hoffmann HH,Rosenberg BR,Rice CM
Thu Feb 08 00:00:00 EST 2018
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.
Cell
Nanki K,Toshimitsu K,Takano A,Fujii M,Shimokawa M,Ohta Y,Matano M,Seino T,Nishikori S,Ishikawa K,Kawasaki K,Togasaki K,Takahashi S,Sukawa Y,Ishida H,Sugimoto S,Kawakubo H,Kim J,Kitagawa Y,Sekine S,Koo BK,Kanai T,Sato T
Thu Aug 09 00:00:00 EDT 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
Growth of Epithelial Organoids in a Defined Hydrogel.
Advanced materials (Deerfield Beach, Fla.)
Broguiere N,Isenmann L,Hirt C,Ringel T,Placzek S,Cavalli E,Ringnalda F,Villiger L,Züllig R,Lehmann R,Rogler G,Heim MH,Schüler J,Zenobi-Wong M,Schwank G
Mon Oct 01 00:00:00 EDT 2018
Targeting c-met receptor tyrosine kinase by the DNA aptamer SL1 as a potential novel therapeutic option for myeloma.
Journal of cellular and molecular medicine
Zhang Y,Gao H,Zhou W,Sun S,Zeng Y,Zhang H,Liang L,Xiao X,Song J,Ye M,Yang Y,Zhao J,Wang Z,Liu J
Sat Dec 01 00:00:00 EST 2018
Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model.
Cell death & disease
Fan JR,Lee HT,Lee W,Lin CH,Hsu CY,Hsieh CH,Shyu WC
Tue May 01 00:00:00 EDT 2018
LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration.
Nature communications
Infante E,Castagnino A,Ferrari R,Monteiro P,Agüera-González S,Paul-Gilloteaux P,Domingues MJ,Maiuri P,Raab M,Shanahan CM,Baffet A,Piel M,Gomes ER,Chavrier P
Fri Jun 22 00:00:00 EDT 2018
Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system.
Scientific reports
Saito Y,Nakaoka T,Muramatsu T,Ojima H,Sukeda A,Sugiyama Y,Uchida R,Furukawa R,Kitahara A,Sato T,Kanai Y,Saito H
Mon Feb 12 00:00:00 EST 2018
CCAAT/Enhancer Binding Protein β inhibits myogenic differentiation via ID3.
Scientific reports
AlSudais H,Lala-Tabbert N,Wiper-Bergeron N
Fri Nov 09 00:00:00 EST 2018
Stem cells in middle ear cholesteatoma contribute to its pathogenesis.
Scientific reports
Nagel J,Wöllner S,Schürmann M,Brotzmann V,Müller J,Greiner JF,Goon P,Kaltschmidt B,Kaltschmidt C,Sudhoff H
Wed Apr 18 00:00:00 EDT 2018
Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications.
Stem cell reports
Ong J,Serra MP,Segal J,Cujba AM,Ng SS,Butler R,Millar V,Hatch S,Zimri S,Koike H,Chan K,Bonham A,Walk M,Voss T,Heaton N,Mitry R,Dhawan A,Ebner D,Danovi D,Nakauchi H,Rashid ST
Tue Mar 13 00:00:00 EDT 2018
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.
Cell stem cell
Fujii M,Matano M,Toshimitsu K,Takano A,Mikami Y,Nishikori S,Sugimoto S,Sato T
100-39 was used in In vitro experiments to investigate maintenance of intestinal organoid culture with reflective cellular diversity.
Thu Dec 06 00:00:00 EST 2018
The adipose tissue stromal vascular fraction secretome enhances the proliferation but inhibits the differentiation of myoblasts.
Stem cell research & therapy
El-Habta R,Sloniecka M,Kingham PJ,Backman LJ
100-39 was used in Cell Culture to evaluate the effects of stromal vascular fraction to establish myoblasts using indirect co-culture experiments.
Thu Dec 20 00:00:00 EST 2018
The adipose tissue stromal vascular fraction secretome enhances the proliferation but inhibits the differentiation of myoblasts.
Stem cell research & therapy
El-Habta R,Sloniecka M,Kingham PJ,Backman LJ
100-39 was used in Cell Culture to evaluate the effects of stromal vascular fraction to establish myoblasts using indirect co-culture experiments.
Thu Dec 20 00:00:00 EST 2018
Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer.
Nature communications
Arechederra M,Daian F,Yim A,Bazai SK,Richelme S,Dono R,Saurin AJ,Habermann BH,Maina F
Wed Aug 08 00:00:00 EDT 2018
Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs.
Nature communications
Ikeda T,Hikichi T,Miura H,Shibata H,Mitsunaga K,Yamada Y,Woltjen K,Miyamoto K,Hiratani I,Yamada Y,Hotta A,Yamamoto T,Okita K,Masui S
Wed Apr 11 00:00:00 EDT 2018
An effective protocol for pharmacological defatting of primary human hepatocytes which is non-toxic to cholangiocytes or intrahepatic endothelial cells.
PloS one
Boteon YL,Wallace L,Boteon APCS,Mirza DF,Mergental H,Bhogal RH,Afford S
100-39 was used in Cell Culture to effectiveness of pharmacological defatting reducing the in vitro lipid content of primary human hepatocytes.
Mon Jan 21 00:00:00 EST 2019
In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity.
Cell stem cell
Zhang K,Zhang L,Liu W,Ma X,Cen J,Sun Z,Wang C,Feng S,Zhang Z,Yue L,Sun L,Zhu Z,Chen X,Feng A,Wu J,Jiang Z,Li P,Cheng X,Gao D,Peng L,Hui L
100-39 was used in Cell Culture to study ideal medium conditions for human hepatocytes for proliferation in injured mouse liver.
Thu Dec 06 00:00:00 EST 2018
RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.
Cancer cell
Chen X,Wu Q,Depeille P,Chen P,Thornton S,Kalirai H,Coupland SE,Roose JP,Bastian BC
Mon May 08 00:00:00 EDT 2017
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Oncogene
Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW
100-39 was used in In vitro experiments to study the specific tumor microenvironment (TME) which most actively control cancer cell plasticity for metastasis.
Thu Jul 13 00:00:00 EDT 2017
Extracellular matrix protein laminin enhances mesenchymal stem cell (MSC) paracrine function through αvβ3/CD61 integrin to reduce cardiomyocyte apoptosis.
Journal of cellular and molecular medicine
Peng KY,Liu YH,Li YW,Yen BL,Yen ML
Tue Aug 01 00:00:00 EDT 2017
HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells.
Nature communications
Lin Y,Fang ZP,Liu HJ,Wang LJ,Cheng Z,Tang N,Li T,Liu T,Han HX,Cao G,Liang L,Ding YQ,Zhou WJ
Fri Oct 27 00:00:00 EDT 2017
HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells.
Nature communications
Lin Y,Fang ZP,Liu HJ,Wang LJ,Cheng Z,Tang N,Li T,Liu T,Han HX,Cao G,Liang L,Ding YQ,Zhou WJ
Fri Oct 27 00:00:00 EDT 2017
Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution.
Scientific reports
Jonsson VD,Blakely CM,Lin L,Asthana S,Matni N,Olivas V,Pazarentzos E,Gubens MA,Bastian BC,Taylor BS,Doyle JC,Bivona TG
Mon Mar 13 00:00:00 EDT 2017
SOX7 Is Required for Muscle Satellite Cell Development and Maintenance.
Stem cell reports
Rajgara RF,Lala-Tabbert N,Marchildon F,Lamarche É,MacDonald JK,Scott DA,Blais A,Skerjanc IS,Wiper-Bergeron N
Tue Oct 10 00:00:00 EDT 2017
Therapeutic potential of human minor salivary gland epithelial progenitor cells in liver regeneration.
Scientific reports
Zhang C,Li Y,Zhang XY,Liu L,Tong HZ,Han TL,Li WD,Jin XL,Yin NB,Song T,Li HD,Zhi J,Zhao ZM,Lu L
Thu Oct 05 00:00:00 EDT 2017
Predicting ligand-dependent tumors from multi-dimensional signaling features.
NPJ systems biology and applications
Hass H,Masson K,Wohlgemuth S,Paragas V,Allen JE,Sevecka M,Pace E,Timmer J,Stelling J,MacBeath G,Schoeberl B,Raue A
Sun Nov 12 00:00:00 EST 2023
Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling.
The Journal of biological chemistry
Sato-Matsubara M,Matsubara T,Daikoku A,Okina Y,Longato L,Rombouts K,Thuy LTT,Adachi J,Tomonaga T,Ikeda K,Yoshizato K,Pinzani M,Kawada N
Fri Nov 17 00:00:00 EST 2017
Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells.
Stem cell reports
Yang J,Wang Y,Zhou T,Wong LY,Tian XY,Hong X,Lai WH,Au KW,Wei R,Liu Y,Cheng LH,Liang G,Huang Z,Fan W,Zhao P,Wang X,Ibañez DP,Luo Z,Li Y,Zhong X,Chen S,Wang D,Li L,Lai L,Qin B,Bao X,Hutchins AP,Siu CW,Huang Y,Esteban MA,Tse HF
Tue Mar 14 00:00:00 EDT 2017
iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer.
Cell death & disease
Xue Y,Han H,Wu L,Pan B,Dong B,Yin CC,Tian Z,Liu X,Yang Y,Zhang H,Chen Y,Chen J
Thu Oct 26 00:00:00 EDT 2017
SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress.
Scientific reports
Patten DA,Kamarajah SK,Rose JM,Tickle J,Shepherd EL,Adams DH,Weston CJ,Shetty S
Thu Dec 14 00:00:00 EST 2017
Investigation of brain tissue infiltration by medulloblastoma cells in an ex vivo model.
Scientific reports
Neve A,Santhana Kumar K,Tripolitsioti D,Grotzer MA,Baumgartner M
Thu Jul 13 00:00:00 EDT 2017
Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane.
Scientific reports
Werbin JL,Avendaño MS,Becker V,Jungmann R,Yin P,Danuser G,Sorger PK
Fri Sep 22 00:00:00 EDT 2017
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis.
Nature communications
Dufton NP,Peghaire CR,Osuna-Almagro L,Raimondi C,Kalna V,Chauhan A,Webb G,Yang Y,Birdsey GM,Lalor P,Mason JC,Adams DH,Randi AM
Thu Oct 12 00:00:00 EDT 2017
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.
Nature communications
Laviolette LA,Mermoud J,Calvo IA,Olson N,Boukhali M,Steinlein OK,Roider E,Sattler EC,Huang D,Teh BT,Motamedi M,Haas W,Iliopoulos O
100-39 was used in Sample Preparation (Western Blotting) to investigate follicular tumour suppressor genes and their interactions with EGFR.
Wed Jun 28 00:00:00 EDT 2017
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.
Nature communications
Laviolette LA,Mermoud J,Calvo IA,Olson N,Boukhali M,Steinlein OK,Roider E,Sattler EC,Huang D,Teh BT,Motamedi M,Haas W,Iliopoulos O
100-39 was used in Sample Preparation (Western Blotting) to investigate follicular tumour suppressor genes and their interactions with EGFR.
Wed Jun 28 00:00:00 EDT 2017
Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells.
Scientific reports
Kotaka M,Toyoda T,Yasuda K,Kitano Y,Okada C,Ohta A,Watanabe A,Uesugi M,Osafune K
Fri Dec 01 00:00:00 EST 2017
Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells.
Scientific reports
Kotaka M,Toyoda T,Yasuda K,Kitano Y,Okada C,Ohta A,Watanabe A,Uesugi M,Osafune K
Fri Dec 01 00:00:00 EST 2017
c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma.
The Journal of clinical investigation
Huang M,Liu T,Ma P,Mitteer RA,Zhang Z,Kim HJ,Yeo E,Zhang D,Cai P,Li C,Zhang L,Zhao B,Roccograndi L,O'Rourke DM,Dahmane N,Gong Y,Koumenis C,Fan Y
Mon May 02 00:00:00 EDT 2016
Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting.
Proceedings of the National Academy of Sciences of the United States of America
Ma X,Qu X,Zhu W,Li YS,Yuan S,Zhang H,Liu J,Wang P,Lai CS,Zanella F,Feng GS,Sheikh F,Chien S,Chen S
Tue Feb 23 00:00:00 EST 2016
Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells.
Molecular therapy. Nucleic acids
Lee PC,Truong B,Vega-Crespo A,Gilmore WB,Hermann K,Angarita SA,Tang JK,Chang KM,Wininger AE,Lam AK,Schoenberg BE,Cederbaum SD,Pyle AD,Byrne JA,Lipshutz GS
Tue Nov 29 00:00:00 EST 2016
P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.
The Journal of cell biology
Hashimoto A,Oikawa T,Hashimoto S,Sugino H,Yoshikawa A,Otsuka Y,Handa H,Onodera Y,Nam JM,Oneyama C,Okada M,Fukuda M,Sabe H
Mon Apr 11 00:00:00 EDT 2016
Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion.
Oncogenesis
Loupe JM,Miller PJ,Bonner BP,Maggi EC,Vijayaraghavan J,Crabtree JS,Taylor CM,Zabaleta J,Hollenbach AD
Mon Jul 25 00:00:00 EDT 2016
Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mTOR signaling pathways in lung cancer.
Molecular therapy oncolytics
Jiao D,Wang J,Lu W,Tang X,Chen J,Mou H,Chen QY
Mon Aug 15 00:00:00 EDT 2016
Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mTOR signaling pathways in lung cancer.
Molecular therapy oncolytics
Jiao D,Wang J,Lu W,Tang X,Chen J,Mou H,Chen QY
Mon Aug 15 00:00:00 EDT 2016
MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1.
Stem cells (Dayton, Ohio)
Jung KH,McCarthy RL,Zhou C,Uprety N,Barton MC,Beretta L
Sun May 01 00:00:00 EDT 2016
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
Nature communications
Hashimoto S,Mikami S,Sugino H,Yoshikawa A,Hashimoto A,Onodera Y,Furukawa S,Handa H,Oikawa T,Okada Y,Oya M,Sabe H
Mon Feb 08 00:00:00 EST 2016
Hepatic Differentiation from Human Ips Cells Using M15 Cells.
Methods in molecular biology (Clifton, N.J.)
Umeda K,Shiraki N,Kume S
100-39 was used in Cell Culture to describe a procedure of human iPS cells differentiation into the definitive endoderm, further into albumin-expressing and albumin-secreting hepatocyte, using M15, a mesonephros- derived cell line.
Fri Oct 14 00:00:00 EDT 2016
Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.
Scientific reports
Kuijk EW,Rasmussen S,Blokzijl F,Huch M,Gehart H,Toonen P,Begthel H,Clevers H,Geurts AM,Cuppen E
Fri Feb 26 00:00:00 EST 2016
Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus.
Scientific reports
Kaneko S,Kakinuma S,Asahina Y,Kamiya A,Miyoshi M,Tsunoda T,Nitta S,Asano Y,Nagata H,Otani S,Kawai-Kitahata F,Murakawa M,Itsui Y,Nakagawa M,Azuma S,Nakauchi H,Nishitsuji H,Ujino S,Shimotohno K,Iwamoto M,Watashi K,Wakita T,Watanabe M
Fri Jul 08 00:00:00 EDT 2016
Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG).
Molecular & cellular proteomics : MCP
Thiesler CT,Cajic S,Hoffmann D,Thiel C,van Diepen L,Hennig R,Sgodda M,Weiβmann R,Reichl U,Steinemann D,Diekmann U,Huber NM,Oberbeck A,Cantz T,Kuss AW,Körner C,Schambach A,Rapp E,Buettner FF
Fri Apr 01 00:00:00 EDT 2016
Basic fibroblast growth factor is pro-adipogenic in rat skeletal muscle progenitor clone, 2G11 cells.
Animal science journal = Nihon chikusan Gakkaiho
Nakano S,Nakamura K,Teramoto N,Yamanouchi K,Nishihara M
100-39 was used in In vitro experiments to suggest that bFGF plays an important role as a key trigger of IMAT formation in vivo.
Fri Jan 01 00:00:00 EST 2016
ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.
Nature communications
Yamaguchi T,Lu C,Ida L,Yanagisawa K,Usukura J,Cheng J,Hotta N,Shimada Y,Isomura H,Suzuki M,Fujimoto T,Takahashi T
Mon Jan 04 00:00:00 EST 2016
Foetal hepatic progenitor cells assume a cholangiocytic cell phenotype during two-dimensional pre-culture.
Scientific reports
Anzai K,Chikada H,Tsuruya K,Ida K,Kagawa T,Inagaki Y,Mine T,Kamiya A
Thu Jun 23 00:00:00 EDT 2016
Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells.
Scientific reports
Kim HM,Kim JW,Choi Y,Chun HS,Im I,Han YM,Song CW,Yoon S,Park HJ
Mon Feb 22 00:00:00 EST 2016
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.
Nature communications
Lee DH,Park JO,Kim TS,Kim SK,Kim TH,Kim MC,Park GS,Kim JH,Kuninaka S,Olson EN,Saya H,Kim SY,Lee H,Lim DS
Thu Jun 30 00:00:00 EDT 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
100-39 was used in Cell Culture to provide a protocol for growing adult mouse and human liver and pancreas organoids from cell isolation and long-term expansion to genetic manipulation in vitro.
Thu Sep 01 00:00:00 EDT 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
100-39 was used in Cell Culture to provide a protocol for growing adult mouse and human liver and pancreas organoids from cell isolation and long-term expansion to genetic manipulation in vitro.
Thu Sep 01 00:00:00 EDT 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
100-39 was used in Cell Culture to provide a protocol for growing adult mouse and human liver and pancreas organoids from cell isolation and long-term expansion to genetic manipulation in vitro.
Thu Sep 01 00:00:00 EDT 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
100-39 was used in Cell Culture to provide a protocol for growing adult mouse and human liver and pancreas organoids from cell isolation and long-term expansion to genetic manipulation in vitro.
Thu Sep 01 00:00:00 EDT 2016
H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro.
Stem cell reports
Vanhove J,Pistoni M,Welters M,Eggermont K,Vanslembrouck V,Helsen N,Boon R,Najimi M,Sokal E,Collas P,Voncken JW,Verfaillie CM
Tue Aug 09 00:00:00 EDT 2016
Hepatic Differentiation from Murine and Human iPS Cells Using Nanofiber Scaffolds.
Methods in molecular biology (Clifton, N.J.)
Yamazoe T,Shiraki N,Kume S
100-39 was used in Cell Culture to describe the procedure to potentiate hepatic lineage cells differentiation from murine and human iPS cells, using growth factor cocktails and nanofiber scaffolds.
Fri Oct 14 00:00:00 EDT 2016
Hepatic Differentiation from Murine and Human iPS Cells Using Nanofiber Scaffolds.
Methods in molecular biology (Clifton, N.J.)
Yamazoe T,Shiraki N,Kume S
100-39 was used in Cell Culture to describe the procedure to potentiate hepatic lineage cells differentiation from murine and human iPS cells, using growth factor cocktails and nanofiber scaffolds.
Fri Oct 14 00:00:00 EDT 2016
Long-term culture of genome-stable bipotent stem cells from adult human liver.
Cell
Huch M,Gehart H,van Boxtel R,Hamer K,Blokzijl F,Verstegen MM,Ellis E,van Wenum M,Fuchs SA,de Ligt J,van de Wetering M,Sasaki N,Boers SJ,Kemperman H,de Jonge J,Ijzermans JN,Nieuwenhuis EE,Hoekstra R,Strom S,Vries RR,van der Laan LJ,Cuppen E,Clevers H
Thu Jan 15 00:00:00 EST 2015
Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release.
Immunity
Komarowska I,Coe D,Wang G,Haas R,Mauro C,Kishore M,Cooper D,Nadkarni S,Fu H,Steinbruchel DA,Pitzalis C,Anderson G,Bucy P,Lombardi G,Breckenridge R,Marelli-Berg FM
Tue Jun 16 00:00:00 EDT 2015
Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release.
Immunity
Komarowska I,Coe D,Wang G,Haas R,Mauro C,Kishore M,Cooper D,Nadkarni S,Fu H,Steinbruchel DA,Pitzalis C,Anderson G,Bucy P,Lombardi G,Breckenridge R,Marelli-Berg FM
Tue Jun 16 00:00:00 EDT 2015
Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance.
Advanced healthcare materials
Villarin BL,Cameron K,Szkolnicka D,Rashidi H,Bates N,Kimber SJ,Flint O,Forbes SJ,Iredale JP,Bradley M,Hay DC
Wed Aug 26 00:00:00 EDT 2015
Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options.
Oncogenesis
Loupe JM,Miller PJ,Ruffin DR,Stark MW,Hollenbach AD
Mon Mar 30 00:00:00 EDT 2015
Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells.
Stem cell reports
Siller R,Greenhough S,Naumovska E,Sullivan GJ
Tue May 12 00:00:00 EDT 2015
Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts.
Scientific reports
Kim J,Kim KP,Lim KT,Lee SC,Yoon J,Song G,Hwang SI,Schöler HR,Cantz T,Han DW
Tue Oct 27 00:00:00 EDT 2015
Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes.
The Journal of biological chemistry
Im I,Jang MJ,Park SJ,Lee SH,Choi JH,Yoo HW,Kim S,Han YM
Fri Dec 04 00:00:00 EST 2015
A cost-effective system for differentiation of intestinal epithelium from human induced pluripotent stem cells.
Scientific reports
Ogaki S,Morooka M,Otera K,Kume S
Mon Nov 30 00:00:00 EST 2015
Identification of cytokine-induced modulation of microRNA expression and secretion as measured by a novel microRNA specific qPCR assay.
Scientific reports
Benes V,Collier P,Kordes C,Stolte J,Rausch T,Muckentaler MU,Häussinger D,Castoldi M
100-39 was used in Cell Culture to suggest that the pleiotropic activity of humoral factors on microRNAs may extensively affect liver function in response to injury and regeneration.
Thu Jun 25 00:00:00 EDT 2015
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.
Stem cell reports
Nantasanti S,Spee B,Kruitwagen HS,Chen C,Geijsen N,Oosterhoff LA,van Wolferen ME,Pelaez N,Fieten H,Wubbolts RW,Grinwis GC,Chan J,Huch M,Vries RRG,Clevers H,de Bruin A,Rothuizen J,Penning LC,Schotanus BA
Tue Nov 10 00:00:00 EST 2015
PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.
Nature communications
Yu JS,Ramasamy TS,Murphy N,Holt MK,Czapiewski R,Wei SK,Cui W
Fri May 22 00:00:00 EDT 2015
Mechanism of Resistance and Novel Targets Mediating Resistance to EGFR and c-Met Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
PloS one
Botting GM,Rastogi I,Chhabra G,Nlend M,Puri N
100-39 was used in Sample Preparation (Western Blotting) to study the similarities and differences in mechanisms of EGFR/c-Met tyrosine kinase inhibitors resistance.
Tue May 17 00:00:00 EDT 2016
Identification of factors regulating MET receptor endocytosis by high-throughput siRNA screening.
Methods in molecular biology (Clifton, N.J.)
Gaziova I,Davey RA,Elferink LA
100-39 was used in In vitro experiments to describe here a rapid and efficient method for identifying cellular factors required for MET ubiquitination, which utilizes high-throughput RNA interference screening (HT-siRNA) with a receptor internalization assay and an In-Cell ELISA in a 96-well format.
Mon Nov 09 00:00:00 EST 2015
Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.
Cell death & disease
Montagne R,Berbon M,Doublet L,Debreuck N,Baranzelli A,Drobecq H,Leroy C,Delhem N,Porte H,Copin MC,Dansin E,Furlan A,Tulasne D
Thu May 21 00:00:00 EDT 2015
CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells.
Stem cell reports
Kido T,Koui Y,Suzuki K,Kobayashi A,Miura Y,Chern EY,Tanaka M,Miyajima A
Tue Oct 13 00:00:00 EDT 2015
Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes.
Stem cell reports
Cameron K,Tan R,Schmidt-Heck W,Campos G,Lyall MJ,Wang Y,Lucendo-Villarin B,Szkolnicka D,Bates N,Kimber SJ,Hengstler JG,Godoy P,Forbes SJ,Hay DC
Tue Dec 08 00:00:00 EST 2015
Real-time monitoring of cell protrusion dynamics by impedance responses.
Scientific reports
Gagliardi PA,Puliafito A,di Blasio L,Chianale F,Somale D,Seano G,Bussolino F,Primo L
Fri May 15 00:00:00 EDT 2015
Computer-assisted quantification of motile and invasive capabilities of cancer cells.
Scientific reports
Kumar KS,Pillong M,Kunze J,Burghardt I,Weller M,Grotzer MA,Schneider G,Baumgartner M
Wed Oct 21 00:00:00 EDT 2015
Hepatic stellate cells contribute to progenitor cells and liver regeneration.
The Journal of clinical investigation
Kordes C,Sawitza I,Götze S,Herebian D,Häussinger D
100-39 was used in Cell Culture to demonstrate that Retinoid-storing hepatic stellate cells (HSCs) represent a source of liver progenitor cells. HSCs from eGFP-expressing rats, purified by retinoid-dependent fluorescence-activated cell sorting and transplanted into wild-type (WT) rats that had undergone partial hepatectomy contributed to liver regeneration in host animals by forming mesenchymal tissue, progenitor cells, hepatocytes, and cholangiocytes and elevated direct bilirubin levels
Mon Dec 01 00:00:00 EST 2014
Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions.
The Journal of cell biology
Bays JL,Peng X,Tolbert CE,Guilluy C,Angell AE,Pan Y,Superfine R,Burridge K,DeMali KA
Mon Apr 28 00:00:00 EDT 2014
PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.
The Journal of cell biology
Gagliardi PA,di Blasio L,Puliafito A,Seano G,Sessa R,Chianale F,Leung T,Bussolino F,Primo L
Mon Aug 04 00:00:00 EDT 2014
Yhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells.
Acta pharmacologica Sinica
He CX,Ai J,Xing WQ,Chen Y,Zhang HT,Huang M,Hu YH,Ding J,Geng MY
Wed Jan 01 00:00:00 EST 2014
Yhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells.
Acta pharmacologica Sinica
He CX,Ai J,Xing WQ,Chen Y,Zhang HT,Huang M,Hu YH,Ding J,Geng MY
Wed Jan 01 00:00:00 EST 2014
B7h triggering inhibits the migration of tumor cell lines.
Journal of immunology (Baltimore, Md. : 1950)
Dianzani C,Minelli R,Gigliotti CL,Occhipinti S,Giovarelli M,Conti L,Boggio E,Shivakumar Y,Baldanzi G,Malacarne V,Orilieri E,Cappellano G,Fantozzi R,Sblattero D,Yagi J,Rojo JM,Chiocchetti A,Dianzani U
Thu May 15 00:00:00 EDT 2014
Enabling autologous human liver regeneration with differentiated adipocyte stem cells.
Cell transplantation
Xu D,Nishimura T,Zheng M,Wu M,Su H,Sato N,Lee G,Michie S,Glenn J,Peltz G
100-39 was used in Cell Culture to determine a new method of hepatocyte-like cells development from adipocyte-like stem cells.
Tue Sep 15 00:00:00 EDT 2015
Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
The Journal of biological chemistry
Ito K,Yamazaki S,Yamamoto R,Tajima Y,Yanagida A,Kobayashi T,Kato-Itoh M,Kakuta S,Iwakura Y,Nakauchi H,Kamiya A
Fri Oct 24 00:00:00 EDT 2014
Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells.
The Journal of biological chemistry
Usatyuk PV,Fu P,Mohan V,Epshtein Y,Jacobson JR,Gomez-Cambronero J,Wary KK,Bindokas V,Dudek SM,Salgia R,Garcia JG,Natarajan V
Fri May 09 00:00:00 EDT 2014
Deriving functional hepatocytes from pluripotent stem cells.
Current protocols in stem cell biology
Szkolnicka D,Farnworth SL,Lucendo-Villarin B,Hay DC
100-39 was used in Cell Culture to develop robust hepatocyte differentiation methodologies for use with pluripotent stem cells.
Fri Aug 01 00:00:00 EDT 2014
ROCK-2 is associated with focal adhesion maturation during myoblast migration.
Journal of cellular biochemistry
Goetsch KP,Snyman C,Myburgh KH,Niesler CU
100-39 was used in In vitro experiments to provide further proof that ROCK-2 regulates directional myoblast migration through focal adhesion formation and maturation.
Tue Jul 01 00:00:00 EDT 2014
Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer.
Blood
Zhang H,Maric I,DiPrima MJ,Khan J,Orentas RJ,Kaplan RN,Mackall CL
Thu Aug 15 00:00:00 EDT 2013
Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles.
Proceedings of the National Academy of Sciences of the United States of America
Hikichi T,Matoba R,Ikeda T,Watanabe A,Yamamoto T,Yoshitake S,Tamura-Nakano M,Kimura T,Kamon M,Shimura M,Kawakami K,Okuda A,Okochi H,Inoue T,Suzuki A,Masui S
Tue Apr 16 00:00:00 EDT 2013
Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells.
Stem cells (Dayton, Ohio)
Sun L,Mathews LA,Cabarcas SM,Zhang X,Yang A,Zhang Y,Young MR,Klarmann KD,Keller JR,Farrar WL
Thu Aug 01 00:00:00 EDT 2013
Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells.
PloS one
Koivuniemi R,Mäkelä J,Hokkanen ME,Bruelle C,Ho TH,Ola R,Korhonen L,Schröder J,Kataoka H,Lindholm D
Mon Jul 29 00:00:00 EDT 2013
Critical role of S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrity.
The Journal of biological chemistry
Ephstein Y,Singleton PA,Chen W,Wang L,Salgia R,Kanteti P,Dudek SM,Garcia JG,Jacobson JR
Fri Jan 25 00:00:00 EST 2013
Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity.
Cell death & disease
Lefebvre J,Muharram G,Leroy C,Kherrouche Z,Montagne R,Ichim G,Tauszig-Delamasure S,Chotteau-Lelievre A,Brenner C,Mehlen P,Tulasne D
Thu Oct 17 00:00:00 EDT 2013
Production of hepatocyte-like cells from human pluripotent stem cells.
Nature protocols
Hannan NR,Segeritz CP,Touboul T,Vallier L
100-39 was used in Cell Culture to describe a 25-d protocol to direct the differentiation of human pluripotent stem cells into a near-homogenous population of hepatocyte-like cells.
Fri Feb 01 00:00:00 EST 2013
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Nature
Wilson TR,Fridlyand J,Yan Y,Penuel E,Burton L,Chan E,Peng J,Lin E,Wang Y,Sosman J,Ribas A,Li J,Moffat J,Sutherlin DP,Koeppen H,Merchant M,Neve R,Settleman J
Thu Jul 26 00:00:00 EDT 2012
Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach.
Molecular therapy : the journal of the American Society of Gene Therapy
Moschidou D,Mukherjee S,Blundell MP,Drews K,Jones GN,Abdulrazzak H,Nowakowska B,Phoolchund A,Lay K,Ramasamy TS,Cananzi M,Nettersheim D,Sullivan M,Frost J,Moore G,Vermeesch JR,Fisk NM,Thrasher AJ,Atala A,Adjaye J,Schorle H,De Coppi P,Guillot PV
Mon Oct 01 00:00:00 EDT 2012
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Kajiwara M,Aoi T,Okita K,Takahashi R,Inoue H,Takayama N,Endo H,Eto K,Toguchida J,Uemoto S,Yamanaka S
Tue Jul 31 00:00:00 EDT 2012
2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen.
The Journal of cell biology
Meyer AS,Hughes-Alford SK,Kay JE,Castillo A,Wells A,Gertler FB,Lauffenburger DA
Mon Jun 11 00:00:00 EDT 2012
Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation.
PLoS pathogens
Wu X,Robotham JM,Lee E,Dalton S,Kneteman NM,Gilbert DM,Tang H
Mon Aug 20 00:00:00 EDT 2012
Microfibrous substrate geometry as a critical trigger for organization, self-renewal, and differentiation of human embryonic stem cells within synthetic 3-dimensional microenvironments.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Carlson AL,Florek CA,Kim JJ,Neubauer T,Moore JC,Cohen RI,Kohn J,Grumet M,Moghe PV
Wed Aug 01 00:00:00 EDT 2012
Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain.
Stem cells international
Nakaguchi K,Jinnou H,Kaneko N,Sawada M,Hikita T,Saitoh S,Tabata Y,Sawamoto K
Thu Oct 25 00:00:00 EDT 2012
Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K, Akt, c-Src, and AP-1 signaling pathway.
PloS one
Chen HT,Tsou HK,Chang CH,Tang CH
Thu Oct 11 00:00:00 EDT 2012
Met receptor tyrosine kinase signaling induces secretion of the angiogenic chemokine interleukin-8/CXCL8 in pancreatic cancer.
PloS one
Hill KS,Gaziova I,Harrigal L,Guerra YA,Qiu S,Sastry SK,Arumugam T,Logsdon CD,Elferink LA
Tue Mar 26 00:00:00 EDT 2013
Mda-9/syntenin is expressed in uveal melanoma and correlates with metastatic progression.
PloS one
Gangemi R,Mirisola V,Barisione G,Fabbi M,Brizzolara A,Lanza F,Mosci C,Salvi S,Gualco M,Truini M,Angelini G,Boccardo S,Cilli M,Airoldi I,Queirolo P,Jager MJ,Daga A,Pfeffer U,Ferrini S
Fri May 11 00:00:00 EDT 2012
The tyrosine kinase c-Met contributes to the pro-tumorigenic function of the p38 kinase in human bile duct cholangiocarcinoma cells.
The Journal of biological chemistry
Dai R,Li J,Fu J,Chen Y,Wang R,Zhao X,Luo T,Zhu J,Ren Y,Cao J,Qian Y,Li N,Wang H
Fri Nov 16 00:00:00 EST 2012
Enhanced PKCδ and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF.
PloS one
Chen YJ,Tsai RK,Wu WC,He MS,Kao YH,Wu WS
Tue Mar 05 00:00:00 EST 2013
Hepatocyte growth factor regulates HLX1 gene expression to modulate HTR-8/SVneo trophoblast cells.
Reproductive biology and endocrinology : RB&E
Liu HY,Jia XQ,Gao LX,Ma YY
Tue Sep 18 00:00:00 EDT 2012
Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.
The Journal of biological chemistry
Le Goff A,Ji Z,Leclercq B,Bourette RP,Mougel A,Guerardel C,de Launoit Y,Vicogne J,Goormachtigh G,Fafeur V
Fri Oct 12 00:00:00 EDT 2012
Ontological differences in first compared to third trimester human fetal placental chorionic stem cells.
PloS one
Jones GN,Moschidou D,Puga-Iglesias TI,Kuleszewicz K,Vanleene M,Shefelbine SJ,Bou-Gharios G,Fisk NM,David AL,De Coppi P,Guillot PV
Tue Jan 22 00:00:00 EST 2013
Nuclear translocation of β-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype.
PloS one
Herencia C,Martínez-Moreno JM,Herrera C,Corrales F,Santiago-Mora R,Espejo I,Barco M,Almadén Y,de la Mata M,Rodríguez-Ariza A,Muñoz-Castañeda JR
Wed Oct 17 00:00:00 EDT 2012
Hepatic differentiation of amniotic epithelial cells.
Hepatology (Baltimore, Md.)
Marongiu F,Gramignoli R,Dorko K,Miki T,Ranade AR,Paola Serra M,Doratiotto S,Sini M,Sharma S,Mitamura K,Sellaro TL,Tahan V,Skvorak KJ,Ellis EC,Badylak SF,Davila JC,Hines R,Laconi E,Strom SC
Sun May 01 00:00:00 EDT 2011
Core promoter recognition complex changes accompany liver development.
Proceedings of the National Academy of Sciences of the United States of America
D'Alessio JA,Ng R,Willenbring H,Tjian R
Tue Mar 08 00:00:00 EST 2011
hTID-1 defines a novel regulator of c-Met Receptor signaling in renal cell carcinomas.
Oncogene
Copeland E,Balgobin S,Lee CM,Rozakis-Adcock M
Thu May 12 00:00:00 EDT 2011
Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.
Journal of immunology (Baltimore, Md. : 1950)
Shetty S,Weston CJ,Oo YH,Westerlund N,Stamataki Z,Youster J,Hubscher SG,Salmi M,Jalkanen S,Lalor PF,Adams DH
Fri Apr 01 00:00:00 EDT 2011
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.
Journal of cell science
Bone HK,Nelson AS,Goldring CE,Tosh D,Welham MJ
Wed Jun 15 00:00:00 EDT 2011
Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.
PloS one
Shiraki N,Yamazoe T,Qin Z,Ohgomori K,Mochitate K,Kume K,Kume S
Fri Feb 24 00:00:00 EST 2012
Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.
PloS one
Shiraki N,Yamazoe T,Qin Z,Ohgomori K,Mochitate K,Kume K,Kume S
Fri Feb 24 00:00:00 EST 2012
Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation.
The Journal of biological chemistry
Fang JD,Chou HC,Tung HH,Huang PY,Lee SL
Fri Feb 18 00:00:00 EST 2011
Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.
Stem cell reviews and reports
Funakoshi N,Duret C,Pascussi JM,Blanc P,Maurel P,Daujat-Chavanieu M,Gerbal-Chaloin S
Thu Sep 01 00:00:00 EDT 2011
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.
The Journal of clinical investigation
Rashid ST,Corbineau S,Hannan N,Marciniak SJ,Miranda E,Alexander G,Huang-Doran I,Griffin J,Ahrlund-Richter L,Skepper J,Semple R,Weber A,Lomas DA,Vallier L
Wed Sep 01 00:00:00 EDT 2010
Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.
Oncogene
Cantelmo AR,Cammarota R,Noonan DM,Focaccetti C,Comoglio PM,Prat M,Albini A
Thu Sep 23 00:00:00 EDT 2010
Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.
Oncogene
Cantelmo AR,Cammarota R,Noonan DM,Focaccetti C,Comoglio PM,Prat M,Albini A
Thu Sep 23 00:00:00 EDT 2010
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Journal of immunology (Baltimore, Md. : 1950)
Oo YH,Weston CJ,Lalor PF,Curbishley SM,Withers DR,Reynolds GM,Shetty S,Harki J,Shaw JC,Eksteen B,Hubscher SG,Walker LS,Adams DH
Mon Mar 15 00:00:00 EDT 2010
Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent apoptosis, but are insensitive to direct activation with exogenous Fas ligand.
PloS one
Humphreys EH,Williams KT,Adams DH,Afford SC
Wed Nov 17 00:00:00 EST 2010
Functional blockade of α5β1 integrin induces scattering and genomic landscape remodeling of hepatic progenitor cells.
BMC cell biology
Vellón L,Royo F,Matthiesen R,Torres-Fuenzalida J,Lorenti A,Parada LA
Tue Oct 19 00:00:00 EDT 2010
VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta.
PloS one
Holmes K,Chapman E,See V,Cross MJ
Tue Jul 06 00:00:00 EDT 2010
A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.
PloS one
Berenguer M,Martinez L,Giorgetti-Peraldi S,Le Marchand-Brustel Y,Govers R
Mon Dec 20 00:00:00 EST 2010
Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells.
Journal of molecular cell biology
Cai J,Yu C,Liu Y,Chen S,Guo Y,Yong J,Lu W,Ding M,Deng H
Mon Feb 01 00:00:00 EST 2010
Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells.
Journal of molecular cell biology
Cai J,Yu C,Liu Y,Chen S,Guo Y,Yong J,Lu W,Ding M,Deng H
Mon Feb 01 00:00:00 EST 2010
Dynamic interaction networks in a hierarchically organized tissue.
Molecular systems biology
Kirouac DC,Ito C,Csaszar E,Roch A,Yu M,Sykes EA,Bader GD,Zandstra PW
Tue Oct 05 00:00:00 EDT 2010
Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice.
PloS one
Factor VM,Seo D,Ishikawa T,Kaposi-Novak P,Marquardt JU,Andersen JB,Conner EA,Thorgeirsson SS
Thu Sep 16 00:00:00 EDT 2010
Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine.
The Journal of biological chemistry
Honda A,Hirose M,Hatori M,Matoba S,Miyoshi H,Inoue K,Ogura A
Fri Oct 08 00:00:00 EDT 2010
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.
Cell research
Song Z,Cai J,Liu Y,Zhao D,Yong J,Duo S,Song X,Guo Y,Zhao Y,Qin H,Yin X,Wu C,Che J,Lu S,Ding M,Deng H
Sun Nov 01 00:00:00 EDT 2009
An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization.
Blood
Jourdan M,Caraux A,De Vos J,Fiol G,Larroque M,Cognot C,Bret C,Duperray C,Hose D,Klein B
Thu Dec 10 00:00:00 EST 2009
Differentiation of Wharton's jelly primitive stromal cells into insulin-producing cells in comparison with bone marrow mesenchymal stem cells.
Tissue engineering. Part A
Wu LF,Wang NN,Liu YS,Wei X
Thu Oct 01 00:00:00 EDT 2009
Efficient proliferation and maturation of fetal liver cells in three-dimensional culture by stimulation of oncostatin M, epidermal growth factor, and dimethyl sulfoxide.
Tissue engineering. Part A
Koyama T,Ehashi T,Ohshima N,Miyoshi H
Fri May 01 00:00:00 EDT 2009
PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells.
BMC cancer
Crosswell HE,Dasgupta A,Alvarado CS,Watt T,Christensen JG,De P,Durden DL,Findley HW
Wed Nov 25 00:00:00 EST 2009
Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver.
PloS one
Baertschiger RM,Serre-Beinier V,Morel P,Bosco D,Peyrou M,Clément S,Sgroi A,Kaelin A,Buhler LH,Gonelle-Gispert C
Mon Aug 17 00:00:00 EDT 2009
Met receptor tyrosine kinase degradation is altered in response to the leucine-rich repeat of the Listeria invasion protein internalin B.
The Journal of biological chemistry
Gao X,Lorinczi M,Hill KS,Brooks NC,Dokainish H,Ireton K,Elferink LA
Fri Jan 09 00:00:00 EST 2009
Analysis of receptor tyrosine kinase internalization using flow cytometry.
Methods in molecular biology (Clifton, N.J.)
Li N,Hill KS,Elferink LA
100-39 was used in Cell Culture to study how cMet signaling for normal cell growth is controlled by endocytosis and study dysregulation of the mechanism occurs in metastatic cancers using a flow cytometry-based assay to study cMet internalization.
Tue Jan 06 00:00:00 EST 2009
Role for amplification and expression of glypican-5 in rhabdomyosarcoma.
Cancer research
Williamson D,Selfe J,Gordon T,Lu YJ,Pritchard-Jones K,Murai K,Jones P,Workman P,Shipley J
Mon Jan 01 00:00:00 EST 2007
The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.
Stem cells (Dayton, Ohio)
Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J
Sun Jul 01 00:00:00 EDT 2007
Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
Developmental dynamics : an official publication of the American Association of Anatomists
Metzger DE,Xu Y,Shannon JM
Tue May 01 00:00:00 EDT 2007
Ras adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy.
Oncogene
Lüdde T,Kubicka S,Plümpe J,Liedtke C,Manns MP,Trautwein C
100-39 was used in In vivo experiments to indicate adv Ras 61L in vivo increases Cyclin E expression by higher transcription via E2F and a post-transcriptional mechanism.
Thu Aug 30 00:00:00 EDT 2001
