Product References
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Nature communications
Chen Y,Chen L,Wu X,Zhao Y,Wang Y,Jiang D,Liu X,Zhou T,Li S,Wei Y,Liu Y,Hu C,Zhou B,Qin J,Ying H,Ding Q
100-39H was used in In vitro experiments to identify an epigenetic mechanism by which the early phase lipid redistribution from adipose tissue to liver during regeneration impacts hepatocyte proliferation, and suggest a potential strategy to boost liver regeneration.
Sat Mar 18 00:00:00 EDT 2023
Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging.
Cell reports methods
LaLone V,Aizenshtadt A,Goertz J,Skottvoll FS,Mota MB,You J,Zhao X,Berg HE,Stokowiec J,Yu M,Schwendeman A,Scholz H,Wilson SR,Krauss S,Stevens MM
100-39H was used in In vitro experiments to develop an integrated bioanalytical methodology, qRamanomics, to qualify Raman spectral imaging as a tissue phantom calibrated tool for quantitative spatial chemotyping of major classes of biomolecules.
Mon Apr 24 00:00:00 EDT 2023
Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination.
STAR protocols
von der Bey M,De Cicco S,Zach S,Hengerer B,Ercan-Herbst E
100-39H was used in In vitro experiments to describe steps to differentiate hiPSCs into cortical neurons and oligodendrocyte lineage cells on 3D nanofibers.
Fri Mar 17 00:00:00 EDT 2023
N-glycosylation regulates MET processing and signaling.
Cancer science
Saitou A,Hasegawa Y,Fujitani N,Ariki S,Uehara Y,Hashimoto U,Saito A,Kuronuma K,Matsumoto K,Chiba H,Takahashi M
100-39H was used in Cell Culture to suggest that N-glycans of MET affect the status and the function of the receptor in a site-specific manner.
Fri Apr 01 00:00:00 EDT 2022
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids.
Science advances
Li P,Li Y,Wang Y,Liu J,Lavrijsen M,Li Y,Zhang R,Verstegen MMA,Wang Y,Li TC,Ma Z,Kainov DE,Bruno MJ,de Man RA,van der Laan LJW,Peppelenbosch MP,Pan Q
Fri Jan 21 00:00:00 EST 2022
Generation, Maintenance and HBV Infection of Human Liver Organoids.
Bio-protocol
Romal S,Hossain T,Mahmoudi T
100-39H was used in Cell Culture to propose the use of human liver organoids as a platform for modeling HBV infection and related tumorigenesis.
Sun Mar 20 00:00:00 EDT 2022
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia.
Life science alliance
Amatngalim GD,Rodenburg LW,Aalbers BL,Raeven HH,Aarts EM,Sarhane D,Spelier S,Lefferts JW,Silva IA,Nijenhuis W,Vrendenbarg S,Kruisselbrink E,Brunsveld JE,van Drunen CM,Michel S,de Winter-de Groot KM,Heijerman HG,Kapitein LC,Amaral MD,van der Ent CK,Beekman JM
100-39H was used in Cell Culture to define organoid culture conditions, with the growth factor/cytokine combination neuregulin-1lt;igt;βlt;/igt; and interleukin-1lt;igt;βlt;/igt;, which enabled consistent detection of CFTR modulator responses in nasal-airway organoid cultures from subjects with cystic fibrosis.
Wed Aug 03 00:00:00 EDT 2022
RAB31 marks and controls an ESCRT-independent exosome pathway.
Cell research
Wei D,Zhan W,Gao Y,Huang L,Gong R,Wang W,Zhang R,Wu Y,Gao S,Kang T
Mon Feb 01 00:00:00 EST 2021
SARS-CoV-2 infection induces beta cell transdifferentiation.
Cell metabolism
Tang X,Uhl S,Zhang T,Xue D,Li B,Vandana JJ,Acklin JA,Bonnycastle LL,Narisu N,Erdos MR,Bram Y,Chandar V,Chong ACN,Lacko LA,Min Z,Lim JK,Borczuk AC,Xiang J,Naji A,Collins FS,Evans T,Liu C,tenOever BR,Schwartz RE,Chen S
Tue Aug 03 00:00:00 EDT 2021
Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells.
American journal of cancer research
Wei KC,Lin YC,Chen CH,Chu YH,Huang CY,Liao WC,Liu CH
100-39H was used in Sample Preparation (WB) to investigate N-linked glucosylation in glioma.
Wed Dec 08 00:00:00 EST 2021
Three-dimensional migration of human amniotic fluid stem cells involves mesenchymal and amoeboid modes and is regulated by mTORC1.
Stem cells (Dayton, Ohio)
Rosner M,Hengstschläger M
Wed Dec 01 00:00:00 EST 2021
SOX9 in prostate cancer is upregulated by cancer-associated fibroblasts to promote tumor progression through HGF/c-Met-FRA1 signaling.
The FEBS journal
Qin H,Yang Y,Jiang B,Pan C,Chen W,Diao W,Ding M,Cao W,Zhang Z,Chen M,Gao J,Zhao X,Qiu X,Guo H
100-39H was used in Cell Culture to investigate mechanisms of SOX9 and Pca biomarker in prostate cancer prognosis.
Wed Sep 01 00:00:00 EDT 2021
Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.
iScience
Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y
Fri Nov 19 00:00:00 EST 2021
Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.
iScience
Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y
Fri Nov 19 00:00:00 EST 2021
ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma.
Cell reports
De Bacco F,Orzan F,Erriquez J,Casanova E,Barault L,Albano R,D'Ambrosio A,Bigatto V,Reato G,Patanè M,Pollo B,Kuesters G,Dell'Aglio C,Casorzo L,Pellegatta S,Finocchiaro G,Comoglio PM,Boccaccio C
Tue Jul 27 00:00:00 EDT 2021
An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer.
Nature communications
Kim J,Park K,Kim MJ,Lim H,Kim KH,Kim SW,Lee ES,Kim HH,Kim SJ,Hur KY,Kim JH,Ahn JH,Yoon KH,Kim JW,Lee MS
Fri Jan 08 00:00:00 EST 2021
PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR.
Cell reports
Ghosh S,Nataraj NB,Noronha A,Patkar S,Sekar A,Mukherjee S,Winograd-Katz S,Kramarski L,Verma A,Lindzen M,Garcia DD,Green J,Eisenberg G,Gil-Henn H,Basu A,Lender Y,Weiss S,Oren M,Lotem M,Geiger B,Ruppin E,Yarden Y
Tue May 25 00:00:00 EDT 2021
Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts.
Scientific reports
Anzai K,Tsuruya K,Ida K,Kagawa T,Inagaki Y,Kamiya A
Fri Sep 17 00:00:00 EDT 2021
Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models.
Cell death & disease
Clark MP,Huynh T,Rao S,Mackiewicz L,Mason H,Romal S,Stutz MD,Ahn SH,Earnest L,Sozzi V,Littlejohn M,Tran BM,Wiedemann N,Vincan E,Torresi J,Netter HJ,Mahmoudi T,Revill P,Pellegrini M,Ebert G
Wed Jun 23 00:00:00 EDT 2021
Shc3 promotes hepatocellular carcinoma stemness and drug resistance by interacting with β-catenin to inhibit its ubiquitin degradation pathway.
Cell death & disease
Liu Y,Zhuang H,Cao F,Li J,Guo Y,Zhang J,Zhao Q,Liu Y
Mon Mar 15 00:00:00 EDT 2021
Directed Differentiation of Human Pluripotent Stem Cells toward Skeletal Myogenic Progenitors and Their Purification Using Surface Markers.
Cells
Xu N,Wu J,Ortiz-Vitali JL,Li Y,Darabi R
100-39H was used in In vitro experiments to develop an improved directed differentiation method for the derivation of skeletal myogenic progenitors from Human Pluripotent Stem Cells.
Thu Oct 14 00:00:00 EDT 2021
Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua.
Cell reports
Cheung VC,Peng CY,Marinić M,Sakabe NJ,Aneas I,Lynch VJ,Ober C,Nobrega MA,Kessler JA
Tue May 18 00:00:00 EDT 2021
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nature
Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP
Tue Sep 01 00:00:00 EDT 2020
A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells.
Cell stem cell
Xi H,Langerman J,Sabri S,Chien P,Young CS,Younesi S,Hicks M,Gonzalez K,Fujiwara W,Marzi J,Liebscher S,Spencer M,Van Handel B,Evseenko D,Schenke-Layland K,Plath K,Pyle AD
100-39H was used in Cell Culture to profile human embryonic, fetal and postnatal skeletal muscle tissues to develop a roadmap of muscle ontogeny.
Thu Jul 02 00:00:00 EDT 2020
Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease.
Scientific reports
Verstegen MMA,Roos FJM,Burka K,Gehart H,Jager M,de Wolf M,Bijvelds MJC,de Jonge HR,Ardisasmita AI,van Huizen NA,Roest HP,de Jonge J,Koch M,Pampaloni F,Fuchs SA,Schene IF,Luider TM,van der Doef HPJ,Bodewes FAJA,de Kleine RHJ,Spee B,Kremers GJ,Clevers H,IJzermans JNM,Cuppen E,van der Laan LJW
Mon Dec 14 00:00:00 EST 2020
The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs.
Cell reports
Michielin F,Giobbe GG,Luni C,Hu Q,Maroni I,Orford MR,Manfredi A,Di Filippo L,David AL,Cacchiarelli D,De Coppi P,Eaton S,Elvassore N
100-39H was used in In vitro experiments to find high abundancy of extracellular matrix (ECM)-associated proteins.
Tue Dec 01 00:00:00 EST 2020
Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells.
Nature protocols
García-León JA,García-Díaz B,Eggermont K,Cáceres-Palomo L,Neyrinck K,Madeiro da Costa R,Dávila JC,Baron-Van Evercooren A,Gutiérrez A,Verfaillie CM
Sun Nov 01 00:00:00 EDT 2020
Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines.
Nature communications
Boon R,Kumar M,Tricot T,Elia I,Ordovas L,Jacobs F,One J,De Smedt J,Eelen G,Bird M,Roelandt P,Doglioni G,Vriens K,Rossi M,Vazquez MA,Vanwelden T,Chesnais F,El Taghdouini A,Najimi M,Sokal E,Cassiman D,Snoeys J,Monshouwer M,Hu WS,Lange C,Carmeliet P,Fendt SM,Verfaillie CM
Fri Mar 13 00:00:00 EDT 2020
Umbilical cord tissue is a robust source for mesenchymal stem cells with enhanced myogenic differentiation potential compared to cord blood.
Scientific reports
Mishra S,Sevak JK,Das A,Arimbasseri GA,Bhatnagar S,Gopinath SD
Wed Nov 04 00:00:00 EST 2020
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.
Cancer cell
Woolston A,Khan K,Spain G,Barber LJ,Griffiths B,Gonzalez-Exposito R,Hornsteiner L,Punta M,Patil Y,Newey A,Mansukhani S,Davies MN,Furness A,Sclafani F,Peckitt C,Jiménez M,Kouvelakis K,Ranftl R,Begum R,Rana I,Thomas J,Bryant A,Quezada S,Wotherspoon A,Khan N,Fotiadis N,Marafioti T,Powles T,Lise S,Calvo F,Guettler S,von Loga K,Rao S,Watkins D,Starling N,Chau I,Sadanandam A,Cunningham D,Gerlinger M
Mon Jul 08 00:00:00 EDT 2019
CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells.
Blood
Edwards DK,Watanabe-Smith K,Rofelty A,Damnernsawad A,Laderas T,Lamble A,Lind EF,Kaempf A,Mori M,Rosenberg M,d'Almeida A,Long N,Agarwal A,Sweeney DT,Loriaux M,McWeeney SK,Tyner JW
Thu Feb 07 00:00:00 EST 2019
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
The Journal of clinical investigation
Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C
Fri Mar 01 00:00:00 EST 2019
Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma.
EMBO molecular medicine
Chua V,Orloff M,Teh JL,Sugase T,Liao C,Purwin TJ,Lam BQ,Terai M,Ambrosini G,Carvajal RD,Schwartz G,Sato T,Aplin AE
Fri Feb 01 00:00:00 EST 2019
Activation of c-Met in cancer cells mediates growth-promoting signals against oxidative stress through Nrf2-HO-1.
Oncogenesis
Chakraborty S,Balan M,Flynn E,Zurakowski D,Choueiri TK,Pal S
Tue Jan 15 00:00:00 EST 2019
Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia.
Scientific reports
Okada H,Nakanishi C,Yoshida S,Shimojima M,Yokawa J,Mori M,Tada H,Yoshimuta T,Hayashi K,Yamano T,Hanayama R,Yamagishi M,Kawashiri MA
Mon Mar 18 00:00:00 EDT 2019
Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease.
Scientific reports
Fujiyoshi J,Yamaza H,Sonoda S,Yuniartha R,Ihara K,Nonaka K,Taguchi T,Ohga S,Yamaza T
Thu Feb 07 00:00:00 EST 2019
Efficient Selection of Antibodies Reactive to Homologous Epitopes on Human and Mouse Hepatocyte Growth Factors by Next-Generation Sequencing-Based Analysis of the B Cell Repertoire.
International journal of molecular sciences
Kim S,Lee H,Noh J,Lee Y,Han H,Yoo DK,Kim H,Kwon S,Chung J
100-39H was used in In vivo experiments to study the YYB-101 is a humanized rabbit anti-human hepatocyte growth factor (HGF)-neutralizing antibody on anti-cancer T cell immunity.
Fri Jan 18 00:00:00 EST 2019
Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.
Cell reports
Sulahian R,Kwon JJ,Walsh KH,Pailler E,Bosse TL,Thaker M,Almanza D,Dempster JM,Pan J,Piccioni F,Dumont N,Gonzalez A,Rennhack J,Nabet B,Bachman JA,Goodale A,Lee Y,Bagul M,Liao R,Navarro A,Yuan TL,Ng RWS,Raghavan S,Gray NS,Tsherniak A,Vazquez F,Root DE,Firestone AJ,Settleman J,Hahn WC,Aguirre AJ
100-39H was used in Sample Preparation (Western Blotting) to demonstrate that knockout, suppression, or degradation of SHOC2, a positive regulator of MAPK signaling, specifically cooperated with MEK inhibition to impair proliferation in RAS-driven cancer cells.
Tue Oct 01 00:00:00 EDT 2019
UBTD1 is a mechano-regulator controlling cancer aggressiveness.
EMBO reports
Torrino S,Roustan FR,Kaminski L,Bertero T,Pisano S,Ambrosetti D,Dufies M,Uhler JP,Lemichez E,Mettouchi A,Gesson M,Laurent K,Gaggioli C,Michiels JF,Lamaze C,Bost F,Clavel S
100-39H was used in In vitro experiments to demonstrate that depletion of UBTD1 drastically affects the mechanical properties of epithelial cancer cells via RhoA activation and strongly promotes their aggressiveness.
Mon Apr 01 00:00:00 EDT 2019
Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.
Nature communications
Seishima R,Leung C,Yada S,Murad KBA,Tan LT,Hajamohideen A,Tan SH,Itoh H,Murakami K,Ishida Y,Nakamizo S,Yoshikawa Y,Wong E,Barker N
Tue Nov 26 00:00:00 EST 2019
Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.
Nature communications
Seishima R,Leung C,Yada S,Murad KBA,Tan LT,Hajamohideen A,Tan SH,Itoh H,Murakami K,Ishida Y,Nakamizo S,Yoshikawa Y,Wong E,Barker N
Tue Nov 26 00:00:00 EST 2019
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.
Nature communications
Tang F,Gao R,Jeevan-Raj B,Wyss CB,Kalathur RKR,Piscuoglio S,Ng CKY,Hindupur SK,Nuciforo S,Dazert E,Bock T,Song S,Buechel D,Morini MF,Hergovich A,Matthias P,Lim DS,Terracciano LM,Heim MH,Hall MN,Christofori G
Tue Dec 17 00:00:00 EST 2019
Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes.
Scientific reports
Schöbel A,Rösch K,Herker E
Thu Mar 01 00:00:00 EST 2018
Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration.
Stem cell research & therapy
Zhang W,Chu W,Liu Q,Coates D,Shang Y,Li C
100-39H was used in In ovo experiments to report the expression, functions, and molecular interactions of deer thymosin beta 10 (TMSB10) in tissue and cells in antler growth.
Tue Jun 19 00:00:00 EDT 2018
A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors.
Cell reports
Wu J,Matthias N,Lo J,Ortiz-Vitali JL,Shieh AW,Wang SH,Darabi R
100-39H was used in Sample Preparation (FC/FACS) to study myogenic differentiation of human pluripotent stem cells using double-reporter cell resource and defined an improved myogenic differentiation and purification strategy.
Tue Nov 13 00:00:00 EST 2018
Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
PloS one
Sambathkumar R,Akkerman R,Dastidar S,Roelandt P,Kumar M,Bajaj M,Mestre Rosa AR,Helsen N,Vanslembrouck V,Kalo E,Khurana S,Laureys J,Gysemans C,Faas MM,de Vos P,Verfaillie CM
100-39H was used in Cell Culture to investigate 14 transcription factors in multipotent adult progenitor cell reprogramming for hepatocyte and endocrine pacreatic-like cell culture.
Tue Jul 31 00:00:00 EDT 2018
Development of Hepatocyte-like Cell Derived from Human Induced Pluripotent Stem cell as a Host for Clinically Isolated Hepatitis C Virus.
Current protocols in stem cell biology
Sa-Ngiamsuntorn K,Hongeng S,Wongkajornsilp A
100-39H was used in Cell Culture to devise protocols to generate hepatocyte-like cells from mesenchymal stem cells, with the ability to host hepatitis C virus clinical isolate or conventional JFH-1 genotype.
Mon Aug 14 00:00:00 EDT 2017
