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Product Details
PV4324
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
163-562
Tag
His-tag
Molecular weight
49.7 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM tris HCl, pH 7.5, with 150mM NaCl, 0.02% Triton X-100, 50% glycerol, 2mM DTT, 0.5mM EDTA
Contains
no preservative
Storage conditions
-80° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Catalytic
Target Information
HIPK3 is a serine/threonine kinase involved in signal transduction, cellular communication, and multidrug resistance of tumors and plays a role in the phosphorylation of FADD. HIPK3 negatively regulates apoptosis by promoting FADD phosphorylation. This kinase enhances androgen receptor-mediated transcription, and may act as a transcriptional corepressor for NK homeodomain transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Androgen receptor-interacting nuclear protein kinase; ANPK; Fas-interacting serine/threonine-protein kinase; FIST; Homeodomain-interacting protein kinase 3; Homolog of protein kinase YAK1; RP1-8L15.1
Gene Aliases: DYRK6; FIST3; HIPK3; PKY; YAK1
UniProt ID: (Human) Q9H422
Entrez Gene ID: (Human) 10114
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