Product References
Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis.
Nature communications
Fankhaenel M,Hashemi FSG,Mourao L,Lucas E,Hosawi MM,Skipp P,Morin X,Scheele CLGJ,Elias S
100-03 was used in Cell Culture to establish Annexin A1 as an upstream cortical cue that regulates LGN to direct planar cell divisions during mammalian epithelial morphogenesis.
Wed Jan 11 00:00:00 EST 2023
Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.
The Journal of clinical investigation
Li Z,Duan H,Jia Y,Zhao C,Li W,Wang X,Gong Y,Dong C,Ma B,Dou S,Zhang B,Li D,Cao Y,Xie L,Zhou Q,Shi W
Tue Jan 04 00:00:00 EST 2022
Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses.
Journal of neuroinflammation
Wang Q,Li HY,Ling ZM,Chen G,Wei ZY
100-03 was used in Cell Culture to find that CCI-related neuroinflammation correlates with Panx 1 activation in Schwann cells, indicating that inhibition of Panx 1 channels in Schwann cells reduces neuropathic pain through the suppression of neuroinflammatory responses.
Tue Oct 04 00:00:00 EDT 2022
Altered inhibitory function in hippocampal CA2 contributes in social memory deficits in Alzheimer's mouse model.
iScience
Rey CC,Robert V,Bouisset G,Loisy M,Lopez S,Cattaud V,Lejards C,Piskorowski RA,Rampon C,Chevaleyre V,Verret L
100-03 was used in In vivo experiments to find that social memory deficits of mouse models of AD are associated with decreased presence of PNN around PV cells and long-term synaptic plasticity in area CA2.
Fri Mar 18 00:00:00 EDT 2022
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia.
Life science alliance
Amatngalim GD,Rodenburg LW,Aalbers BL,Raeven HH,Aarts EM,Sarhane D,Spelier S,Lefferts JW,Silva IA,Nijenhuis W,Vrendenbarg S,Kruisselbrink E,Brunsveld JE,van Drunen CM,Michel S,de Winter-de Groot KM,Heijerman HG,Kapitein LC,Amaral MD,van der Ent CK,Beekman JM
100-03 was used in Cell Culture to define organoid culture conditions, with the growth factor/cytokine combination neuregulin-1lt;igt;βlt;/igt; and interleukin-1lt;igt;βlt;/igt;, which enabled consistent detection of CFTR modulator responses in nasal-airway organoid cultures from subjects with cystic fibrosis.
Wed Aug 03 00:00:00 EDT 2022
Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems.
EMBO molecular medicine
Peschke K,Jakubowsky H,Schäfer A,Maurer C,Lange S,Orben F,Bernad R,Harder FN,Eiber M,Öllinger R,Steiger K,Schlitter M,Weichert W,Mayr U,Phillip V,Schlag C,Schmid RM,Braren RF,Kong B,Demir IE,Friess H,Rad R,Saur D,Schneider G,Reichert M
100-03 was used in Tissue/organ culture to demonstrate that treatment-induced tumor cell plasticity in vivo distinctly changes responsiveness to targeted therapies, without the presence of a selectable genetic marker, indicating that tumor cell plasticity can be functionalized.
Thu Apr 07 00:00:00 EDT 2022
Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance.
Cell
Chaturvedi S,Vasen G,Pablo M,Chen X,Beutler N,Kumar A,Tanner E,Illouz S,Rahgoshay D,Burnett J,Holguin L,Chen PY,Ndjamen B,Ott M,Rodick R,Rogers T,Smith DM,Weinberger LS
100-03 was used in Cell Culture to provide proof of concept for a class of single-administration antivirals that may circumvent current requirements to continually update medical countermeasures against new variants.
Thu Dec 09 00:00:00 EST 2021
A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3.
mAbs
Rau A,Kocher K,Rommel M,Kühl L,Albrecht M,Gotthard H,Aschmoneit N,Noll B,Olayioye MA,Kontermann RE,Seifert O
100-03 was used in Cell Culture to present a novel bivalent and bispecific antagonistic molecule (Dab-Fc) targeting human epidermal growth factors 2 and 3 (HER2 and HER3) derived from the Db-Ig platform, which was developed for the generation of multivalent and multispecific antibody molecules.
Wed Jan 19 00:00:00 EST 2022
Defining the regenerative effects of native spider silk fibers on primary Schwann cells, sensory neurons, and nerve-associated fibroblasts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Millesi F,Weiss T,Mann A,Haertinger M,Semmler L,Supper P,Pils D,Naghilou A,Radtke C
Mon Feb 01 00:00:00 EST 2021
Lung injury in axolotl salamanders induces an organ-wide proliferation response.
Developmental dynamics : an official publication of the American Association of Anatomists
Jensen TB,Giunta P,Schultz NG,Griffiths JM,Duerr TJ,Kyeremateng Y,Wong H,Adesina A,Monaghan JR
100-03 was used in In vivo experiments to characterize axolotl lung regeneration.
Tue Jun 01 00:00:00 EDT 2021
Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.
Nature communications
Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H
100-03 was used in Sample Preparation (FC/FACS) to report a chemically defined xeno-free culture system which can be used to culture and derive human extended pluripotent stem (EPS) cells in vitro.
Fri May 21 00:00:00 EDT 2021
Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.
Nature communications
Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H
100-03 was used in Sample Preparation (FC/FACS) to report a chemically defined xeno-free culture system which can be used to culture and derive human extended pluripotent stem (EPS) cells in vitro.
Fri May 21 00:00:00 EDT 2021
ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma.
Cell reports
De Bacco F,Orzan F,Erriquez J,Casanova E,Barault L,Albano R,D'Ambrosio A,Bigatto V,Reato G,Patanè M,Pollo B,Kuesters G,Dell'Aglio C,Casorzo L,Pellegatta S,Finocchiaro G,Comoglio PM,Boccaccio C
Tue Jul 27 00:00:00 EDT 2021
Protocol for establishing organoids from human ovarian cancer biopsies.
STAR protocols
Maenhoudt N,Vankelecom H
100-03 was used in Cell Culture to provide a detailed protocol for establishing organoid cultures from patient OC biopsies.
Fri Jun 18 00:00:00 EDT 2021
Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple-Negative Breast Cancer Tumor Growth.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Y,Zhou Y,Ma X,Chen L
Mon Feb 01 00:00:00 EST 2021
Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection.
Cell reports
Parent AV,Faleo G,Chavez J,Saxton M,Berrios DI,Kerper NR,Tang Q,Hebrok M
Tue Aug 17 00:00:00 EDT 2021
Cilium induction triggers differentiation of glioma stem cells.
Cell reports
Goranci-Buzhala G,Mariappan A,Ricci-Vitiani L,Josipovic N,Pacioni S,Gottardo M,Ptok J,Schaal H,Callaini G,Rajalingam K,Dynlacht B,Hadian K,Papantonis A,Pallini R,Gopalakrishnan J
Tue Sep 07 00:00:00 EDT 2021
An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement.
Communications biology
O'Donnell JC,Purvis EM,Helm KVT,Adewole DO,Zhang Q,Le AD,Cullen DK
Thu Jul 15 00:00:00 EDT 2021
Non-xenogeneic expansion and definitive endoderm differentiation of human pluripotent stem cells in an automated bioreactor.
Biotechnology and bioengineering
Jacobson EF,Chen Z,Stoukides DM,Nair GG,Hebrok M,Tzanakakis ES
100-03 was used in In vitro experiments to demonstrate the xeno-free expansion and directed differentiation of human embryonic and induced pluripotent stem cells to definitive endoderm (DE) in a controlled stirred suspension bioreactor (SSB).
Mon Feb 01 00:00:00 EST 2021
Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration.
Development (Cambridge, England)
de Bakker DEM,Bouwman M,Dronkers E,Simões FC,Riley PR,Goumans MJ,Smits AM,Bakkers J
100-03 was used in In vivo experiments to indicate that Prrx1 is a key transcription factor that balances fibrosis and regeneration in the injured zebrafish heart.
Fri Oct 01 00:00:00 EDT 2021
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors.
Nature communications
Geusz RJ,Wang A,Lam DK,Vinckier NK,Alysandratos KD,Roberts DA,Wang J,Kefalopoulou S,Ramirez A,Qiu Y,Chiou J,Gaulton KJ,Ren B,Kotton DN,Sander M
Wed Nov 17 00:00:00 EST 2021
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer.
Life (Basel, Switzerland)
Liu LM,Tang Q,Hu X,Zhao JJ,Zhang Y,Ying GG,Zhang F
100-03 was used in Cell Culture to show that p53 function is regulated by PRMT1 in breast cancer cells.
Thu Aug 05 00:00:00 EDT 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
100-03 was used in In vitro experiments to establish an efficient human alveolosphere culture method and sphere-based drug testing platform for SARS-CoV-2.
Tue Jun 08 00:00:00 EDT 2021
Lithium Loaded Octa-Poly(Ethylene Glycol) Based Adhesive Facilitates Axon Regeneration and Reconnection of Transected Peripheral Nerves.
Advanced healthcare materials
Bu Y,Wang X,Li L,Hu X,Tan D,Li Z,Lai M,Qiu X,Sun F,Wang H,Yang F,Wu D,Guo J
Wed Jul 01 00:00:00 EDT 2020
Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.
Cell systems
Gerosa L,Chidley C,Fröhlich F,Sanchez G,Lim SK,Muhlich J,Chen JY,Vallabhaneni S,Baker GJ,Schapiro D,Atanasova MI,Chylek LA,Shi T,Yi L,Nicora CD,Claas A,Ng TSC,Kohler RH,Lauffenburger DA,Weissleder R,Miller MA,Qian WJ,Wiley HS,Sorger PK
100-03 was used in Enzyme-linked immunosorbent assay to show that pulsatile MAPK activation by factors in the microenvironment generates a persistent population of melanoma cells that rewires MAPK signaling to sustain non-genetic drug resistance.
Wed Nov 18 00:00:00 EST 2020
Inhibition of Tumor Cell Growth and Cancer Stem Cell Expansion by a Bispecific Antibody Targeting EGFR and HER3.
Molecular cancer therapeutics
Rau A,Lieb WS,Seifert O,Honer J,Birnstock D,Richter F,Aschmoneit N,Olayioye MA,Kontermann RE
100-03 was used in In vitro experiments to develop a novel bispecific antibody targeting EGFR and HER3 for the use as a potential cancer therapy.
Wed Jul 01 00:00:00 EDT 2020
ANXA1 directs Schwann cells proliferation and migration to accelerate nerve regeneration through the FPR2/AMPK pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Xia W,Zhu J,Wang X,Tang Y,Zhou P,Hou M,Li S
Thu Oct 01 00:00:00 EDT 2020
Regulation of the EGFR/ErbB signalling by clathrin in response to various ligands in hepatocellular carcinoma cell lines.
Journal of cellular and molecular medicine
Liu Y,Calmel C,Desbois-Mouthon C,Sobczak-Thépot J,Karaiskou A,Praz F
Wed Jul 01 00:00:00 EDT 2020
A small molecule inhibitor of HER3: a proof-of-concept study.
The Biochemical journal
Colomba A,Fitzek M,George R,Weitsman G,Roberts S,Zanetti-Domingues L,Hirsch M,Rolfe DJ,Mehmood S,Madin A,Claus J,Kjaer S,Snijders AP,Ng T,Martin-Fernandez M,Smith DM,Parker PJ
100-03 was used in In vitro experiments to investigate compounds and identify selective small molecule inhibitor on HER3 regulation.
Fri Sep 18 00:00:00 EDT 2020
A small molecule inhibitor of HER3: a proof-of-concept study.
The Biochemical journal
Colomba A,Fitzek M,George R,Weitsman G,Roberts S,Zanetti-Domingues L,Hirsch M,Rolfe DJ,Mehmood S,Madin A,Claus J,Kjaer S,Snijders AP,Ng T,Martin-Fernandez M,Smith DM,Parker PJ
100-03 was used in In vitro experiments to investigate compounds and identify selective small molecule inhibitor on HER3 regulation.
Fri Sep 18 00:00:00 EDT 2020
Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia.
Molecular brain
Aldana BI,Zhang Y,Jensen P,Chandrasekaran A,Christensen SK,Nielsen TT,Nielsen JE,Hyttel P,Larsen MR,Waagepetersen HS,Freude KK
100-03 was used in Cell Culture to study changes in metabolism at a cellular level which are implicated in frontotemporal dementia (FTD) and in neurodegeneration.
Mon Sep 14 00:00:00 EDT 2020
Recapitulation of Neural Crest Specification and EMT via Induction from Neural Plate Border-like Cells.
Stem cell reports
Kobayashi GS,Musso CM,Moreira DP,Pontillo-Guimarães G,Hsia GSP,Caires-Júnior LC,Goulart E,Passos-Bueno MR
Tue Sep 08 00:00:00 EDT 2020
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
Nature communications
Chang KC,Diermeier SD,Yu AT,Brine LD,Russo S,Bhatia S,Alsudani H,Kostroff K,Bhuiya T,Brogi E,Pappin DJ,Bennett CF,Rigo F,Spector DL
Tue Dec 22 00:00:00 EST 2020
Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination.
eLife
Zhou L,Shao CY,Xie YJ,Wang N,Xu SM,Luo BY,Wu ZY,Ke YH,Qiu M,Shen Y
100-03 was used in Sample Preparation (Western Blotting) to investigate platelet-derived growth factor signaling in oligodendrocyte precursor cells.
Thu Jan 16 00:00:00 EST 2020
The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling.
Oncogene
Cui Y,Groth S,Troutman S,Carlstedt A,Sperka T,Riecken LB,Kissil JL,Jin H,Morrison H
Sun Sep 01 00:00:00 EDT 2019
The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling.
Oncogene
Cui Y,Groth S,Troutman S,Carlstedt A,Sperka T,Riecken LB,Kissil JL,Jin H,Morrison H
Sun Sep 01 00:00:00 EDT 2019
Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury.
Glia
Su WF,Wu F,Jin ZH,Gu Y,Chen YT,Fei Y,Chen H,Wang YX,Xing LY,Zhao YY,Yuan Y,Tang X,Chen G
100-03 was used in Cell Culture to study the distribution and function of P2X4R in the peripheral nervous system to show that P2X4R is mainly localized in the lysosomes of Schwann cells and that expression after nerve injury may be an effective approach to facilitate the regrowth and remyelination of injured nerves.
Tue Jan 01 00:00:00 EST 2019
Clozapine-dependent inhibition of EGF/neuregulin receptor (ErbB) kinases.
Translational psychiatry
Kobayashi Y,Iwakura Y,Sotoyama H,Kitayama E,Takei N,Someya T,Nawa H
Thu Aug 01 00:00:00 EDT 2019
Clozapine-dependent inhibition of EGF/neuregulin receptor (ErbB) kinases.
Translational psychiatry
Kobayashi Y,Iwakura Y,Sotoyama H,Kitayama E,Takei N,Someya T,Nawa H
Thu Aug 01 00:00:00 EDT 2019
Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform Neurofibromas.
Stem cell reports
Carrió M,Mazuelas H,Richaud-Patin Y,Gel B,Terribas E,Rosas I,Jimenez-Delgado S,Biayna J,Vendredy L,Blanco I,Castellanos E,Lázaro C,Raya Á,Serra E
Tue Feb 12 00:00:00 EST 2019
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Cell
Sachs N,de Ligt J,Kopper O,Gogola E,Bounova G,Weeber F,Balgobind AV,Wind K,Gracanin A,Begthel H,Korving J,van Boxtel R,Duarte AA,Lelieveld D,van Hoeck A,Ernst RF,Blokzijl F,Nijman IJ,Hoogstraat M,van de Ven M,Egan DA,Zinzalla V,Moll J,Boj SF,Voest EE,Wessels L,van Diest PJ,Rottenberg S,Vries RGJ,Cuppen E,Clevers H
Thu Jan 11 00:00:00 EST 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 EST 2018
3D bio-printed scaffold-free nerve constructs with human gingiva-derived mesenchymal stem cells promote rat facial nerve regeneration.
Scientific reports
Zhang Q,Nguyen PD,Shi S,Burrell JC,Cullen DK,Le AD
Thu Apr 26 00:00:00 EDT 2018
Differentiation of adipose-derived stem cells into Schwann cell-like cells through intermittent induction: potential advantage of cellular transient memory function.
Stem cell research & therapy
Sun X,Zhu Y,Yin HY,Guo ZY,Xu F,Xiao B,Jiang WL,Guo WM,Meng HY,Lu SB,Wang Y,Peng J
100-03 was used in Cell Culture to investigate mesenchymal stromal cell-derived Schwann cell-like cell treatment for peripheral nerve injury.
Fri May 11 00:00:00 EDT 2018
Detailed Protocols for the Isolation, Culture, Enrichment and Immunostaining of Primary Human Schwann Cells.
Methods in molecular biology (Clifton, N.J.)
Weiss T,Taschner-Mandl S,Ambros PF,Ambros IM
100-03 was used in Cell Culture to describe protocols for the effective establishment of highly enriched human Schwann cell cultures and their characterization via immunostaining.
Mon Jan 07 00:00:00 EST 2019
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Oncogene
Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW
Thu Jul 13 00:00:00 EDT 2017
Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface.
Glia
O'Neill P,Lindsay SL,Pantiru A,Guimond SE,Fagoe N,Verhaagen J,Turnbull JE,Riddell JS,Barnett SC
Sun Jan 01 00:00:00 EST 2017
Predicting ligand-dependent tumors from multi-dimensional signaling features.
NPJ systems biology and applications
Hass H,Masson K,Wohlgemuth S,Paragas V,Allen JE,Sevecka M,Pace E,Timmer J,Stelling J,MacBeath G,Schoeberl B,Raue A
Sun Nov 12 00:00:00 EST 2023
Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells.
Scientific reports
Momeny M,Zarrinrad G,Moghaddaskho F,Poursheikhani A,Sankanian G,Zaghal A,Mirshahvaladi S,Esmaeili F,Eyvani H,Barghi F,Sabourinejad Z,Alishahi Z,Yousefi H,Ghasemi R,Dardaei L,Bashash D,Chahardouli B,Dehpour AR,Tavakkoly-Bazzaz J,Alimoghaddam K,Ghavamzadeh A,Ghaffari SH
Fri Jun 23 00:00:00 EDT 2017
High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.
Stem cells translational medicine
Thorne N,Malik N,Shah S,Zhao J,Class B,Aguisanda F,Southall N,Xia M,McKew JC,Rao M,Zheng W
100-03 was used in Cell Culture to develop as assay to identify compounds that protect against oxidative stress, a condition associated with many neurodegenerative diseases using astrocytes differentiated from human embryonic stem cells.
Sun May 01 00:00:00 EDT 2016
Perinatal Exposure to Neuregulin-1 Results in Disinhibition of Adult Midbrain Dopaminergic Neurons: Implication in Schizophrenia Modeling.
Scientific reports
Namba H,Okubo T,Nawa H
Thu Mar 03 00:00:00 EST 2016
BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells.
Scientific reports
Liu X,Zhao Y,Peng S,Zhang S,Wang M,Chen Y,Zhang S,Yang Y,Sun C
Fri Aug 05 00:00:00 EDT 2016
Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts.
Journal of cellular and molecular medicine
Hensley MT,de Andrade J,Keene B,Meurs K,Tang J,Wang Z,Caranasos TG,Piedrahita J,Li TS,Cheng K
Sat Aug 01 00:00:00 EDT 2015
The Lin28/let-7 axis is critical for myelination in the peripheral nervous system.
Nature communications
Gökbuget D,Pereira JA,Bachofner S,Marchais A,Ciaudo C,Stoffel M,Schulte JH,Suter U
Wed Oct 14 00:00:00 EDT 2015
PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.
Nature communications
Yu JS,Ramasamy TS,Murphy N,Holt MK,Czapiewski R,Wei SK,Cui W
Fri May 22 00:00:00 EDT 2015
All-trans-retinoic Acid Modulates the Plasticity and Inhibits the Motility of Breast Cancer Cells: ROLE OF NOTCH1 AND TRANSFORMING GROWTH FACTOR (TGFβ).
The Journal of biological chemistry
Zanetti A,Affatato R,Centritto F,Fratelli M,Kurosaki M,Barzago MM,Bolis M,Terao M,Garattini E,Paroni G
Fri Jul 17 00:00:00 EDT 2015
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.
Scientific reports
Miller MA,Moss ML,Powell G,Petrovich R,Edwards L,Meyer AS,Griffith LG,Lauffenburger DA
Mon Oct 19 00:00:00 EDT 2015
HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design.
mAbs
de Goeij BE,Peipp M,de Haij S,van den Brink EN,Kellner C,Riedl T,de Jong R,Vink T,Strumane K,Bleeker WK,Parren PW
100-03 was used in Cell Culture to study a large panel of human epidermal growth factor receptor (HER2) antibodies to identify the characteristics that make them most suitable for an antibody-drug conjugates (ADC) approach.
Tue Nov 18 00:00:00 EST 2014
Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.
Journal of immunology (Baltimore, Md. : 1950)
Dreymueller D,Martin C,Schumacher J,Groth E,Boehm JK,Reiss LK,Uhlig S,Ludwig A
Wed Jan 15 00:00:00 EST 2014
An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration.
The Journal of biological chemistry
Park BH,Kook S,Lee S,Jeong JH,Brufsky A,Lee BC
Fri Oct 04 00:00:00 EDT 2013
Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein.
The Journal of biological chemistry
Döppler H,Bastea LI,Eiseler T,Storz P
Fri Jan 04 00:00:00 EST 2013
Neuregulin facilitates nerve regeneration by speeding Schwann cell migration via ErbB2/3-dependent FAK pathway.
PloS one
Chang HM,Shyu MK,Tseng GF,Liu CH,Chang HS,Lan CT,Hsu WM,Liao WC
Tue Aug 20 00:00:00 EDT 2013
A functional comparison between the HER2(high)/HER3 and the HER2(low)/HER3 dimers on heregulin-β1-induced MMP-1 and MMP-9 expression in breast cancer cells.
Experimental & molecular medicine
Kim S,Han J,Shin I,Kil WH,Lee JE,Nam SJ
Fri Aug 31 00:00:00 EDT 2012
2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen.
The Journal of cell biology
Meyer AS,Hughes-Alford SK,Kay JE,Castillo A,Wells A,Gertler FB,Lauffenburger DA
Mon Jun 11 00:00:00 EDT 2012
Impaired Pten expression in human malignant peripheral nerve sheath tumours.
PloS one
Bradtmöller M,Hartmann C,Zietsch J,Jäschke S,Mautner VF,Kurtz A,Park SJ,Baier M,Harder A,Reuss D,von Deimling A,Heppner FL,Holtkamp N
Tue Apr 23 00:00:00 EDT 2013
Impaired Pten expression in human malignant peripheral nerve sheath tumours.
PloS one
Bradtmöller M,Hartmann C,Zietsch J,Jäschke S,Mautner VF,Kurtz A,Park SJ,Baier M,Harder A,Reuss D,von Deimling A,Heppner FL,Holtkamp N
Tue Apr 23 00:00:00 EDT 2013
A scalable system for production of functional pancreatic progenitors from human embryonic stem cells.
PloS one
Schulz TC,Young HY,Agulnick AD,Babin MJ,Baetge EE,Bang AG,Bhoumik A,Cepa I,Cesario RM,Haakmeester C,Kadoya K,Kelly JR,Kerr J,Martinson LA,McLean AB,Moorman MA,Payne JK,Richardson M,Ross KG,Sherrer ES,Song X,Wilson AZ,Brandon EP,Green CE,Kroon EJ,Kelly OG,D'Amour KA,Robins AJ
Wed Sep 19 00:00:00 EDT 2012
Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility.
The Journal of biological chemistry
Rana MK,Worthylake RA
Fri Jun 22 00:00:00 EDT 2012
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
The Journal of biological chemistry
Liu Q,Kirubakaran S,Hur W,Niepel M,Westover K,Thoreen CC,Wang J,Ni J,Patricelli MP,Vogel K,Riddle S,Waller DL,Traynor R,Sanda T,Zhao Z,Kang SA,Zhao J,Look AT,Sorger PK,Sabatini DM,Gray NS
Fri Mar 23 00:00:00 EDT 2012
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.
Cancer cell
Chang CY,Kazmin D,Jasper JS,Kunder R,Zuercher WJ,McDonnell DP
Tue Oct 18 00:00:00 EDT 2011
MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.
The Journal of clinical investigation
Wu X,Simpson J,Hong JH,Kim KH,Thavarajah NK,Backx PH,Neel BG,Araki T
Tue Mar 01 00:00:00 EST 2011
The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro.
Aging cell
Liu S,Liu S,Wang X,Zhou J,Cao Y,Wang F,Duan E
Mon Aug 01 00:00:00 EDT 2011
Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells.
The Journal of biological chemistry
Park BH,Lee SB,Stolz DB,Lee YJ,Lee BC
Fri Jun 03 00:00:00 EDT 2011
Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling.
Nature
Fazzari P,Paternain AV,Valiente M,Pla R,Luján R,Lloyd K,Lerma J,Marín O,Rico B
Thu Apr 29 00:00:00 EDT 2010
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BMC cell biology
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BMC neuroscience
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Blood
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BMC genomics
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