Gibco

Human IGF-BP2 Recombinant Protein, PeproTech®

Product Details

350-06B-20UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 5 publications 5 publications

Product Specifications

Species

Human

Published species

Human

Expression System

Insect cells

Amino acid sequence

EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ

Molecular weight

31.5 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

350-06B-1MG will be provided as 2 x 500 µg (350-06B-500UG).

Recombinant Human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IGFBP2 (insulin-like growth factor binding protein 2) is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.

Journal of immunology (Baltimore, Md. : 1950)

Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM

Fri Feb 15 00:00:00 EST 2019

Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.

Cell

Qin EY,Cooper DD,Abbott KL,Lennon J,Nagaraja S,Mackay A,Jones C,Vogel H,Jackson PK,Monje M

Thu Aug 24 00:00:00 EDT 2017

Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected].

Scientific reports

Nixon CC,Schwartz BH,Dixit D,Zack JA,Vatakis DN

Mon Mar 02 00:00:00 EST 2015

Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model.

Molecular therapy. Nucleic acids

Haemmerle R,Phaltane R,Rothe M,Schröder S,Schambach A,Moritz T,Modlich U

Tue Oct 07 00:00:00 EDT 2014

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.

Proceedings of the National Academy of Sciences of the United States of America

Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA

Tue Mar 19 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: IBP-2; IGF binding protein 2; IGF-binding protein 2; IGFBP; Insulin like growth factor binding protein; insulin-like growth factor binding protein 2; insulin-like growth factor binding protein 2, 36kDa; Insulin-like growth factor-binding protein 2; OTTHUMP00000207753