Gibco

Human IGF-I Recombinant Protein, PeproTech®

Human IGF-I Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Human IGF-I Protein (100-11-500UG) in Functional

Bioassay analysis of Human IGF-I Recombinant Protein, PeproTech® (Product # 100-11-1MG).

Product Image Gallery

Product Details

100-11-500UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

View 2 publications 2 publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 221 publications 221 publications

Miscellaneous PubMed (Misc)

View 50 publications 50 publications

Product Specifications

Species

Human

Published species

Amphibian, Bacteria, Bovine, Cat, Chicken, Dog, Human, Mouse, Non-human primate, Pig, Rat, Sheep, Zebrafish

Expression System

E. coli

Amino acid sequence

GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA

Molecular weight

7.6 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-I is 7.6 kDa.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IGF1 (Insulin-like growth factor-1) is structurally and functionally related to insulin but has a much higher growth-promoting activity. A variety of cellular responses are induced by IGF1, including cell proliferation, differentiation, migration, and survival. Further, IGF1 is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types in muscle, bone, and cartilage tissue. IGF1 stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regards to enhancing glucose uptake. In circulation, IGFs are predominantly bound to binding proteins (IGFBPs) which prolong the half-life of the IGFs and play a role in delivering them to target tissues. IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of proliferation and an inhibitor of programmed cell death. Moreover, mature human IGF-I is 100% homologous with bovine and porcine proteins. Low levels of IGF1 have been linked to Alzheimer's disease. IGF1 is processed from a precursor, bound by a specific receptor, and secreted. Defects in the IGF1 gene are a cause of insulin-like growth factor 1 deficiency and several transcript variants encoding different isoforms have been found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.

iScience

Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y

100-11 was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.

Fri Oct 20 00:00:00 EDT 2023

Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination.

STAR protocols

von der Bey M,De Cicco S,Zach S,Hengerer B,Ercan-Herbst E

100-11 was used in In vitro experiments to describe steps to differentiate hiPSCs into cortical neurons and oligodendrocyte lineage cells on 3D nanofibers.

Fri Mar 17 00:00:00 EDT 2023

A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.

Cell stem cell

Gadomski S,Fielding C,García-García A,Korn C,Kapeni C,Ashraf S,Villadiego J,Toro RD,Domingues O,Skepper JN,Michel T,Zimmer J,Sendtner R,Dillon S,Poole KES,Holdsworth G,Sendtner M,Toledo-Aral JJ,De Bari C,McCaskie AW,Robey PG,Méndez-Ferrer S

100-11 was used in Cell Culture to uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis and skeletal turnover through bone-anabolic effects.

Thu Apr 07 00:00:00 EDT 2022

Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.

The Journal of clinical investigation

Li Z,Duan H,Jia Y,Zhao C,Li W,Wang X,Gong Y,Dong C,Ma B,Dou S,Zhang B,Li D,Cao Y,Xie L,Zhou Q,Shi W

Tue Jan 04 00:00:00 EST 2022

Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.

EMBO reports

Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB

100-11 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.

Thu Feb 03 00:00:00 EST 2022

Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.

EMBO reports

Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB

100-11 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.

Thu Feb 03 00:00:00 EST 2022

Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies.

Cell proliferation

Li T,Lu H,Zhou L,Jia M,Zhang L,Wu H,Shan L

Fri Apr 01 00:00:00 EDT 2022

IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner.

Glia

Pinto-Benito D,Paradela-Leal C,Ganchala D,de Castro-Molina P,Arevalo MA

100-11 was used in Cell Culture to investigate IGF-1 regulation of phagocytosis via PI3K.

Wed Jun 01 00:00:00 EDT 2022

Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemic.

Heart rhythm

Hamrick SK,John Kim CS,Tester DJ,Giudicessi JR,Ackerman MJ

100-11 was used in Cell Culture to ascertain the effects of acidosis and hydroxychloroquine (HCQ) on the action potential duration (APD) in a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of p.S1103Y-SCN5A.

Sun May 01 00:00:00 EDT 2022

A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.

RNA (New York, N.Y.)

Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF

100-11 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.

Thu Sep 01 00:00:00 EDT 2022

Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.

JID innovations : skin science from molecules to population health

Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH

100-11 was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.

Sat Jan 01 00:00:00 EST 2022

OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease.

NPJ Regenerative medicine

Yun W,Choi KA,Hwang I,Zheng J,Park M,Hong W,Jang AY,Kim JH,Choi W,Kim DS,Kim IY,Kim YJ,Liu Y,Yoon BS,Park G,Song G,Hong S,You S

Thu Jan 13 00:00:00 EST 2022

Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation.

Cells

Raabe FJ,Stephan M,Waldeck JB,Huber V,Demetriou D,Kannaiyan N,Galinski S,Glaser LV,Wehr MC,Ziller MJ,Schmitt A,Falkai P,Rossner MJ

100-11 was used in In vitro experiments to highlight that TFs for generating iOPCs or iOLs should be chosen depending on the intended application or research question, and that SON might be beneficial to study more mature iOLs while S might be better suited to investigate iOPC biology.

Tue Jan 11 00:00:00 EST 2022

Artesunate inhibits proliferation and migration of RPE cells and TGF-β2 mediated epithelial mesenchymal transition by suppressing PI3K/AKT pathway.

International journal of ophthalmology

Wang ZY,Zhang Y,Wu LD,Chen J,Chen ML,Chen CM,Xu QH

100-11 was used in Cell Culture to indicate that PI3K/.

Wed Feb 23 00:00:00 EST 2022

Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.

STAR protocols

Martinez-Silgado A,Yousef Yengej FA,Puschhof J,Geurts V,Boot C,Geurts MH,Rookmaaker MB,Verhaar MC,Beumer J,Clevers H

100-11 was used in In vitro experiments to investigate the effects of BMP agonists on differentiation of human small intestinal organoids.

Fri Sep 16 00:00:00 EDT 2022

Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons.

Cell reports

Huang CY,Nicholson MW,Wang JY,Ting CY,Tsai MH,Cheng YC,Liu CL,Chan DZH,Lee YC,Hsu CC,Hsu YH,Yang CF,Chang CMC,Ruan SC,Lin PJ,Lin JH,Chen LL,Hsieh ML,Cheng YY,Hsu WT,Lin YL,Chen CH,Hsu YH,Wu YT,Hacker TA,Wu JC,Kamp TJ,Hsieh PCH

100-11 was used in Cell Culture to study a a population-based human induced pluripotent stem cell (hiPSC) drug screening platform for toxicity assessment.

Tue Apr 05 00:00:00 EDT 2022

Microarrayed human bone marrow organoids for modeling blood stem cell dynamics.

APL bioengineering

Giger S,Hofer M,Miljkovic-Licina M,Hoehnel S,Brandenberg N,Guiet R,Ehrbar M,Kleiner E,Gegenschatz-Schmid K,Matthes T,Lutolf MP

100-11 was used in Sample Preparation (FC/FACS) to propose an organoid system as a preclinical model for pharmacokinetic assays and toxicity studies of novel drugs in a bone marrow niche-mimicking 3D environment.

Thu Sep 01 00:00:00 EDT 2022

RAB31 marks and controls an ESCRT-independent exosome pathway.

Cell research

Wei D,Zhan W,Gao Y,Huang L,Gong R,Wang W,Zhang R,Wu Y,Gao S,Kang T

Mon Feb 01 00:00:00 EST 2021

H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.

Cancer cell

Haag D,Mack N,Benites Goncalves da Silva P,Statz B,Clark J,Tanabe K,Sharma T,Jäger N,Jones DTW,Kawauchi D,Wernig M,Pfister SM

Mon Mar 08 00:00:00 EST 2021

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape.

Cell metabolism

Salvadori G,Zanardi F,Iannelli F,Lobefaro R,Vernieri C,Longo VD

100-11 was used in Cell Culture to investigate fast-mimicking diet in tripe-negative breast cancer treatment.

Tue Nov 02 00:00:00 EDT 2021

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape.

Cell metabolism

Salvadori G,Zanardi F,Iannelli F,Lobefaro R,Vernieri C,Longo VD

100-11 was used in Cell Culture to investigate fast-mimicking diet in tripe-negative breast cancer treatment.

Tue Nov 02 00:00:00 EDT 2021

SARS-CoV-2 infection induces beta cell transdifferentiation.

Cell metabolism

Tang X,Uhl S,Zhang T,Xue D,Li B,Vandana JJ,Acklin JA,Bonnycastle LL,Narisu N,Erdos MR,Bram Y,Chandar V,Chong ACN,Lacko LA,Min Z,Lim JK,Borczuk AC,Xiang J,Naji A,Collins FS,Evans T,Liu C,tenOever BR,Schwartz RE,Chen S

Tue Aug 03 00:00:00 EDT 2021

Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function.

Cell stem cell

Xiong M,Tao Y,Gao Q,Feng B,Yan W,Zhou Y,Kotsonis TA,Yuan T,You Z,Wu Z,Xi J,Haberman A,Graham J,Block J,Zhou W,Chen Y,Zhang SC

Thu Jan 07 00:00:00 EST 2021

Principles of signaling pathway modulation for enhancing human naive pluripotency induction.

Cell stem cell

Bayerl J,Ayyash M,Shani T,Manor YS,Gafni O,Massarwa R,Kalma Y,Aguilera-Castrejon A,Zerbib M,Amir H,Sheban D,Geula S,Mor N,Weinberger L,Naveh Tassa S,Krupalnik V,Oldak B,Livnat N,Tarazi S,Tawil S,Wildschutz E,Ashouokhi S,Lasman L,Rotter V,Hanna S,Ben-Yosef D,Novershtern N,Viukov S,Hanna JH

Thu Sep 02 00:00:00 EDT 2021

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival.

Developmental cell

Gagliardi PA,Dobrzyński M,Jacques MA,Dessauges C,Ender P,Blum Y,Hughes RM,Cohen AR,Pertz O

Mon Jun 21 00:00:00 EDT 2021

Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats.

Experimental & molecular medicine

Yang JM,Chung S,Yun K,Kim B,So S,Kang S,Kang E,Lee JY

Thu Apr 01 00:00:00 EDT 2021

Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Stertz L,Di Re J,Pei G,Fries GR,Mendez E,Li S,Smith-Callahan L,Raventos H,Tipo J,Cherukuru R,Zhao Z,Liu Y,Jia P,Laezza F,Walss-Bass C

Mon Feb 01 00:00:00 EST 2021

Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.

Stem cells translational medicine

Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H

Tue Jun 01 00:00:00 EDT 2021

Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGFβR Regulating TGF-β/Smad Pathway.

Oxidative medicine and cellular longevity

Du H,Gu J,Peng Q,Wang X,Liu L,Shu X,He Q,Tan Y

Mon Feb 07 00:00:00 EST 2022

Three-dimensional migration of human amniotic fluid stem cells involves mesenchymal and amoeboid modes and is regulated by mTORC1.

Stem cells (Dayton, Ohio)

Rosner M,Hengstschläger M

Wed Dec 01 00:00:00 EST 2021

IGF-I and NGFβ enhance in vitro progressive motility and vitality of human spermatozoa.

Reproductive medicine and biology

Asimakopoulos B,Tiptiri-Kourpeti A,Metallinou C

Thu Jul 01 00:00:00 EDT 2021

Role of PI3K/AKT Signaling Pathway in Nucleus Pulposus Cells.

BioMed research international

Xiao Q,Teng Y,Xu C,Pan W,Yang H,Zhao J,Zhou Q

Wed Sep 22 00:00:00 EDT 2021

Electroacupuncture Promotes the Survival of the Grafted Human MGE Neural Progenitors in Rats with Cerebral Ischemia by Promoting Angiogenesis and Inhibiting Inflammation.

Neural plasticity

Li J,Chen L,Li D,Lu M,Huang X,Han X,Chen H

Wed Mar 02 00:00:00 EST 2022

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.

Cell reports

Pettinato AM,Yoo D,VanOudenhove J,Chen YS,Cohn R,Ladha FA,Yang X,Thakar K,Romano R,Legere N,Meredith E,Robson P,Regnier M,Cotney JL,Murry CE,Hinson JT

Tue May 04 00:00:00 EDT 2021

Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.

Nature communications

Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H

100-11 was used in Sample Preparation (FC/FACS) to report a chemically defined xeno-free culture system which can be used to culture and derive human extended pluripotent stem (EPS) cells in vitro.

Fri May 21 00:00:00 EDT 2021

Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.

Nature communications

Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H

100-11 was used in Sample Preparation (FC/FACS) to report a chemically defined xeno-free culture system which can be used to culture and derive human extended pluripotent stem (EPS) cells in vitro.

Fri May 21 00:00:00 EDT 2021

Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.

Nature communications

Pessoa Rodrigues C,Chatterjee A,Wiese M,Stehle T,Szymanski W,Shvedunova M,Akhtar A

Wed Oct 27 00:00:00 EDT 2021

Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment.

Cell reports

Dong X,Yang L,Liu K,Ji X,Tang C,Li W,Ma L,Mei Y,Peng T,Feng B,Wu Z,Tang Q,Gao Y,Yan K,Zhou W,Xiong M

Tue Mar 02 00:00:00 EST 2021

One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2.

Stem cell reports

Chanoumidou K,Hernández-Rodríguez B,Windener F,Thomas C,Stehling M,Mozafari S,Albrecht S,Ottoboni L,Antel J,Kim KP,Velychko S,Cui QL,Xu YKT,Martino G,Winkler J,Schöler HR,Baron-Van Evercooren A,Boespflug-Tanguy O,Vaquerizas JM,Ehrlich M,Kuhlmann T

Tue Apr 13 00:00:00 EDT 2021

Bioengineered model of the human motor unit with physiologically functional neuromuscular junctions.

Scientific reports

Rimington RP,Fleming JW,Capel AJ,Wheeler PC,Lewis MP

Thu Jun 03 00:00:00 EDT 2021

Optimization of Neurite Tracing and Further Characterization of Human Monocyte-Derived-Neuronal-like Cells.

Brain sciences

Bellon A,Hasoglu T,Peterson M,Gao K,Chen M,Blandin E,Cortez-Resendiz A,Clawson GA,Hong LE

100-11 was used in Cell Culture to transdifferentiate monocytes to neuronal-like cells with a rapid new protocol.

Wed Oct 20 00:00:00 EDT 2021

Protocol for establishing organoids from human ovarian cancer biopsies.

STAR protocols

Maenhoudt N,Vankelecom H

100-11 was used in Cell Culture to provide a detailed protocol for establishing organoid cultures from patient OC biopsies.

Fri Jun 18 00:00:00 EDT 2021

Cilium induction triggers differentiation of glioma stem cells.

Cell reports

Goranci-Buzhala G,Mariappan A,Ricci-Vitiani L,Josipovic N,Pacioni S,Gottardo M,Ptok J,Schaal H,Callaini G,Rajalingam K,Dynlacht B,Hadian K,Papantonis A,Pallini R,Gopalakrishnan J

Tue Sep 07 00:00:00 EDT 2021

AKT3 Expression in Mesenchymal Colorectal Cancer Cells Drives Growth and Is Associated with Epithelial-Mesenchymal Transition.

Cancers

Buikhuisen JY,Gomez Barila PM,Torang A,Dekker D,de Jong JH,Cameron K,Vitale S,Stassi G,van Hooff SR,Castro MAA,Vermeulen L,Medema JP

100-11 was used in In vitro experiments to investigate the role of CMS4 signalling on colorectal cancer phenotypes.

Sun Feb 14 00:00:00 EST 2021

Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates.

Cell discovery

Chen H,Xia K,Huang W,Li H,Wang C,Ma Y,Chen J,Luo P,Zheng S,Wang J,Wang Y,Dong L,Tan Z,Lai X,Mao FF,Li W,Liang X,Wang T,Xiang AP,Ke Q

Tue Aug 31 00:00:00 EDT 2021

Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway.

Cell death & disease

Liu X,Yin Z,Xu L,Liu H,Jiang L,Liu S,Sun X

Wed Feb 10 00:00:00 EST 2021

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.

Nature communications

Prelli Bozzo C,Nchioua R,Volcic M,Koepke L,Krüger J,Schütz D,Heller S,Stürzel CM,Kmiec D,Conzelmann C,Müller J,Zech F,Braun E,Groß R,Wettstein L,Weil T,Weiß J,Diofano F,Rodríguez Alfonso AA,Wiese S,Sauter D,Münch J,Goffinet C,Catanese A,Schön M,Boeckers TM,Stenger S,Sato K,Just S,Kleger A,Sparrer KMJ,Kirchhoff F

Wed Jul 28 00:00:00 EDT 2021

Deep learning-based predictive identification of neural stem cell differentiation.

Nature communications

Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R

100-11 was used in Cell Culture to showcase effectiveness of deep learning-based platform in precisely, accurately and robustly detecting NSC differentiation.

Mon May 10 00:00:00 EDT 2021

Deep learning-based predictive identification of neural stem cell differentiation.

Nature communications

Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R

100-11 was used in Cell Culture to showcase effectiveness of deep learning-based platform in precisely, accurately and robustly detecting NSC differentiation.

Mon May 10 00:00:00 EDT 2021

Directed Differentiation of Human Pluripotent Stem Cells toward Skeletal Myogenic Progenitors and Their Purification Using Surface Markers.

Cells

Xu N,Wu J,Ortiz-Vitali JL,Li Y,Darabi R

100-11 was used in In vitro experiments to develop an improved directed differentiation method for the derivation of skeletal myogenic progenitors from Human Pluripotent Stem Cells.

Thu Oct 14 00:00:00 EDT 2021

Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability.

Cell reports

Cui Y,Wang Y,Song X,Ning H,Zhang Y,Teng Y,Wang J,Yang X

Tue Jul 06 00:00:00 EDT 2021

GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small-cell lung cancer.

Cell death & disease

Song JW,Zhu J,Wu XX,Tu T,Huang JQ,Chen GZ,Liang LY,Zhou CH,Xu X,Gong LY

Thu Oct 21 00:00:00 EDT 2021

Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.

iScience

de Castro Fonseca M,de Oliveira JF,Araujo BHS,Canateli C,do Prado PFV,Amorim Neto DP,Bosque BP,Rodrigues PV,de Godoy JVP,Tostes K,Filho HVR,Nascimento AFZ,Saito A,Tonoli CCC,Batista FAH,de Oliveira PSL,Figueira AC,Souza da Costa S,Krepischi ACV,Rosenberg C,Westfahl H,da Silva AJR,Franchini KG

Fri Aug 20 00:00:00 EDT 2021

CODEX, a neural network approach to explore signaling dynamics landscapes.

Molecular systems biology

Jacques MA,Dobrzyński M,Gagliardi PA,Sznitman R,Pertz O

Thu Apr 01 00:00:00 EDT 2021

EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.

Cancers

Bleijs M,Pleijte C,Engels S,Ringnalda F,Meyer-Wentrup F,van de Wetering M,Clevers H

100-11 was used in Cell Culture to investigate potential treatment for desmoplastic small round cell tumour.

Thu Dec 02 00:00:00 EST 2021

Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices.

Cells

Walz M,Höflich C,Walz C,Ohde D,Brenmoehl J,Sawitzky M,Vernunft A,Zettl UK,Holtze S,Hildebrandt TB,Wolf E,Hoeflich A

100-11 was used in In vitro experiments to develop a bioassay for assessing the IGF-related activation of the AKT/mTOR pathway.

Wed Feb 24 00:00:00 EST 2021

Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices.

Cells

Walz M,Höflich C,Walz C,Ohde D,Brenmoehl J,Sawitzky M,Vernunft A,Zettl UK,Holtze S,Hildebrandt TB,Wolf E,Hoeflich A

100-11 was used in In vitro experiments to develop a bioassay for assessing the IGF-related activation of the AKT/mTOR pathway.

Wed Feb 24 00:00:00 EST 2021

Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.

Stem cell research & therapy

Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N

100-11 was used in In vitro experiments to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.

Tue Sep 28 00:00:00 EDT 2021

Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis.

Cell reports

Wegscheid ML,Anastasaki C,Hartigan KA,Cobb OM,Papke JB,Traber JN,Morris SM,Gutmann DH

Tue Jul 06 00:00:00 EDT 2021

BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs.

Stem cell research & therapy

Jin J,Ou Q,Wang Z,Tian H,Xu JY,Gao F,Hu S,Chen J,Wang J,Zhang J,Lu L,Jin C,Xu GT,Zhao J

100-11 was used in Cell Culture to investigate development of skin cells and bone-marrow mesenchymal stem cells in systemic sclerosis.

Sat Jun 05 00:00:00 EDT 2021

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.

Nature

Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ,Shido K,Spence JR,Zhou QJ,Schwartz RE,De Coppi P,Rabbany SY,Rafii S

Tue Sep 01 00:00:00 EDT 2020

Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.

Cell

Yao M,Ventura PB,Jiang Y,Rodriguez FJ,Wang L,Perry JSA,Yang Y,Wahl K,Crittenden RB,Bennett ML,Qi L,Gong CC,Li XN,Barres BA,Bender TP,Ravichandran KS,Janes KA,Eberhart CG,Zong H

Thu Feb 06 00:00:00 EST 2020

Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer.

Signal transduction and targeted therapy

Zheng Y,Wu C,Yang J,Zhao Y,Jia H,Xue M,Xu D,Yang F,Fu D,Wang C,Hu B,Zhang Z,Li T,Yan S,Wang X,Nelson PJ,Bruns C,Qin L,Dong Q

Wed May 13 00:00:00 EDT 2020

Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation.

Cell stem cell

Ortmann D,Brown S,Czechanski A,Aydin S,Muraro D,Huang Y,Tomaz RA,Osnato A,Canu G,Wesley BT,Skelly DA,Stegle O,Choi T,Churchill GA,Baker CL,Rugg-Gunn PJ,Munger SC,Reinholdt LG,Vallier L

100-11 was used in Cell Culture to investigate the variability in experimental reproducibility of pluripotent stem cell lines in mice.

Thu Sep 03 00:00:00 EDT 2020

Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.

EMBO molecular medicine

Di Matteo F,Pipicelli F,Kyrousi C,Tovecci I,Penna E,Crispino M,Chambery A,Russo R,Ayo-Martin AC,Giordano M,Hoffmann A,Ciusani E,Canafoglia L,Götz M,Di Giaimo R,Cappello S

Mon Jun 08 00:00:00 EDT 2020

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production.

Developmental cell

Frame JM,Kubaczka C,Long TL,Esain V,Soto RA,Hachimi M,Jing R,Shwartz A,Goessling W,Daley GQ,North TE

100-11 was used in In vitro experiments to establish the inflammasome as a conserved metabolic sensor that expands HSPC production in vivo and in vitro.

Mon Oct 26 00:00:00 EDT 2020

Hyaluronate supports hESC-cardiomyocyte cell therapy for cardiac regeneration after acute myocardial infarction.

Cell proliferation

Tan Y,Wang L,Chen G,Liu W,Li Z,Wang Y,Wang L,Li W,Wu J,Hao J

Tue Dec 01 00:00:00 EST 2020

Aspirin sensitizes osimertinib-resistant NSCLC cells in vitro and in vivo via Bim-dependent apoptosis induction.

Molecular oncology

Han R,Hao S,Lu C,Zhang C,Lin C,Li L,Wang Y,Hu C,He Y

Mon Jun 01 00:00:00 EDT 2020

USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway.

Journal of cellular and molecular medicine

Yu B,Shen B,Ba Z,Liu Z,Yuan J,Zhao W,Wu D

Tue Dec 01 00:00:00 EST 2020

Odontogenesis and neuronal differentiation characteristics of periodontal ligament stem cells from beagle dog.

Journal of cellular and molecular medicine

Li X,Liao D,Sun G,Chu H

Fri May 01 00:00:00 EDT 2020

Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering.

Journal of biomedical materials research. Part B, Applied biomaterials

Reid JA,Callanan A

Wed Apr 01 00:00:00 EDT 2020

Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models.

Cell death & disease

de la Fuente S,Sansa A,Hidalgo I,Vivancos N,Romero-Guevara R,Garcera A,Soler RM

Thu Jun 25 00:00:00 EDT 2020

LncRNA TMPO-AS1 promotes hepatocellular carcinoma cell proliferation, migration and invasion through sponging miR-329-3p to stimulate FOXK1-mediated AKT/mTOR signaling pathway.

Cancer medicine

Guo X,Wang Y

Wed Jul 01 00:00:00 EDT 2020

Growth factors-based beneficial effects of platelet lysate on umbilical cord-derived stem cells and their synergistic use in osteoarthritis treatment.

Cell death & disease

Yan L,Zhou L,Yan B,Zhang L,Du W,Liu F,Yuan Q,Tong P,Shan L,Efferth T

Wed Oct 14 00:00:00 EDT 2020

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers.

Nature communications

Di Tano M,Raucci F,Vernieri C,Caffa I,Buono R,Fanti M,Brandhorst S,Curigliano G,Nencioni A,de Braud F,Longo VD

Mon May 11 00:00:00 EDT 2020

Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.

Molecular cell

Xiang Y,Tanaka Y,Patterson B,Hwang SM,Hysolli E,Cakir B,Kim KY,Wang W,Kang YJ,Clement EM,Zhong M,Lee SH,Cho YS,Patra P,Sullivan GJ,Weissman SM,Park IH

100-11 was used in In vitro experiments to study the function of methyl-CpG binding protein 2 (MeCP2) using 2D and 3D human brain cultures.

Thu Jul 02 00:00:00 EDT 2020

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway.

Molecular systems biology

Gillies TE,Pargett M,Silva JM,Teragawa CK,McCormick F,Albeck JG

Thu Oct 01 00:00:00 EDT 2020

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.

Nature communications

Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J

Fri Jun 12 00:00:00 EDT 2020

Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.

Nature communications

Rodríguez-Fdez S,Lorenzo-Martín LF,Fernández-Pisonero I,Porteiro B,Veyrat-Durebex C,Beiroa D,Al-Massadi O,Abad A,Diéguez C,Coppari R,Nogueiras R,Bustelo XR

Mon Nov 16 00:00:00 EST 2020

IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway.

Cells

Riis S,Murray JB,O'Connor R

100-11 was used in Cell Culture to investigate the mechanisms involved in IGF-1 leading to BNIP3 induction.

Wed Jan 08 00:00:00 EST 2020

Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia.

Molecular brain

Aldana BI,Zhang Y,Jensen P,Chandrasekaran A,Christensen SK,Nielsen TT,Nielsen JE,Hyttel P,Larsen MR,Waagepetersen HS,Freude KK

100-11 was used in Cell Culture to study changes in metabolism at a cellular level which are implicated in frontotemporal dementia (FTD) and in neurodegeneration.

Mon Sep 14 00:00:00 EDT 2020

Modulating electrospun polycaprolactone scaffold morphology and composition to alter endothelial cell proliferation and angiogenic gene response.

PloS one

Reid JA,McDonald A,Callanan A

Tue Dec 08 00:00:00 EST 2020

Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling.

Journal of experimental & clinical cancer research : CR

Yang J,Li Y,Zhang Y,Fang X,Chen N,Zhou X,Wang X

100-11 was used in Cell Culture to study the expression and functions of Sirt6 in diffuse large B-cell lymphoma (DLBCL) and in response to the regulatory role of the OSS_128167 small molecular inhibitor targeting Sirt6.

Sat Jul 25 00:00:00 EDT 2020

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells.

Journal of visualized experiments : JoVE

Jeon K,Park K,Jetten AM

100-11 was used in In vitro experiments to study inefficient and time-cosuming standard approaches for human embryonic stem cell (hESC) culture using colony type culture to maintain undifferentiated hESCs and embryoid body (EB) and rosette formation for differentiation into different germ layers to instead present a single-cell culture method using hESCs instead of a colony-type culture.

Sat Jan 18 00:00:00 EST 2020

PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle.

International journal of molecular sciences

Verbrugge SAJ,Gehlert S,Stadhouders LEM,Jacko D,Aussieker T,M J de Wit G,Vogel ISP,Offringa C,Schönfelder M,Jaspers RT,Wackerhage H

100-11 was used in Cell Culture to conclude that PKM2 contributes to hypertrophy in C2C12 myotubes and indicates a changed metabolic environment within hypertrophying human skeletal muscle fibers.

Fri Sep 25 00:00:00 EDT 2020

Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.

Nature communications

Araki R,Hoki Y,Suga T,Obara C,Sunayama M,Imadome K,Fujita M,Kamimura S,Nakamura M,Wakayama S,Nagy A,Wakayama T,Abe M

Fri Jan 10 00:00:00 EST 2020

Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination.

eLife

Zhou L,Shao CY,Xie YJ,Wang N,Xu SM,Luo BY,Wu ZY,Ke YH,Qiu M,Shen Y

100-11 was used in Sample Preparation (Western Blotting) to investigate platelet-derived growth factor signaling in oligodendrocyte precursor cells.

Thu Jan 16 00:00:00 EST 2020

A 13-plex of tetra- and penta-STRs to identify zebrafish.

Scientific reports

Venta PJ,Nguyen AK,Senut MC,Poulos WG,Prukudom S,Cibelli JB

Mon Mar 02 00:00:00 EST 2020

Methylation Status of the Nanog Promoter Determines the Switch between Cancer Cells and Cancer Stem Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu S,Cheng K,Zhang H,Kong R,Wang S,Mao C,Liu S

Sun Mar 01 00:00:00 EST 2020

Umbilical cord tissue is a robust source for mesenchymal stem cells with enhanced myogenic differentiation potential compared to cord blood.

Scientific reports

Mishra S,Sevak JK,Das A,Arimbasseri GA,Bhatnagar S,Gopinath SD

Wed Nov 04 00:00:00 EST 2020

Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model.

eLife

Lee H,Lee HY,Lee BE,Gerovska D,Park SY,Zaehres H,Araúzo-Bravo MJ,Kim JI,Ha Y,Schöler HR,Kim JB

100-11 was used in Cell Culture to investigate the use of induced motor neurons to treat spinal cord injury.

Tue Jun 23 00:00:00 EDT 2020

FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.

Nature neuroscience

Picchiarelli G,Demestre M,Zuko A,Been M,Higelin J,Dieterlé S,Goy MA,Mallik M,Sellier C,Scekic-Zahirovic J,Zhang L,Rosenbohm A,Sijlmans C,Aly A,Mersmann S,Sanjuan-Ruiz I,Hübers A,Messaddeq N,Wagner M,van Bakel N,Boutillier AL,Ludolph A,Lagier-Tourenne C,Boeckers TM,Dupuis L,Storkebaum E

100-11 was used in Cell Culture to conclude that FUS regulates acetylcholine receptor gene expression in subsynaptic myonuclei, and muscle-intrinsic toxicity of ALS mutant FUS may contribute to dying-back motor neuronopathy.

Fri Nov 01 00:00:00 EDT 2019

Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.

Cell stem cell

Nobuta H,Yang N,Ng YH,Marro SG,Sabeur K,Chavali M,Stockley JH,Killilea DW,Walter PB,Zhao C,Huie P,Goldman SA,Kriegstein AR,Franklin RJM,Rowitch DH,Wernig M

100-11 was used in Cell Culture to demonstrate that patient-derived oligodendrocytes can develop to the pre-myelinating stage, but subsequently undergo cell death using induced pluripotent stem cell (iPSC) and gene-correction.

Thu Oct 03 00:00:00 EDT 2019

PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.

The Journal of clinical investigation

Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C

Fri Mar 01 00:00:00 EST 2019

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.

Neuron

Geraghty AC,Gibson EM,Ghanem RA,Greene JJ,Ocampo A,Goldstein AK,Ni L,Yang T,Marton RM,Paşca SP,Greenberg ME,Longo FM,Monje M

Wed Jul 17 00:00:00 EDT 2019

Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs.

Neuron

Zhang Y,Williams PR,Jacobi A,Wang C,Goel A,Hirano AA,Brecha NC,Kerschensteiner D,He Z

Wed Jul 03 00:00:00 EDT 2019

Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.

Molecular psychiatry

Vasistha NA,Johnstone M,Barton SK,Mayerl SE,Thangaraj Selvaraj B,Thomson PA,Dando O,Grünewald E,Alloza C,Bastin ME,Livesey MR,Economides K,Magnani D,Makedonopolou P,Burr K,Story DJ,Blackwood DHR,Wyllie DJA,McIntosh AM,Millar JK,Ffrench-Constant C,Hardingham GE,Lawrie SM,Chandran S

Fri Nov 01 00:00:00 EDT 2019

Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2.

Breast cancer research : BCR

Slocum E,Craig A,Villanueva A,Germain D

100-11 was used in Cell Culture to support the notion that information about pregnancy may be critical in the prognosis of breast cancer as passage through a single pregnancy predisposes to the oncogenic action of PAPP-A.

Thu May 02 00:00:00 EDT 2019

Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS.

Glia

Dubessy AL,Mazuir E,Rappeneau Q,Ou S,Abi Ghanem C,Piquand K,Aigrot MS,Thétiot M,Desmazières A,Chan E,Fitzgibbon M,Fleming M,Krauss R,Zalc B,Ranscht B,Lubetzki C,Sol-Foulon N

Sun Dec 01 00:00:00 EST 2019

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.

Human molecular genetics

Baron DM,Matheny T,Lin YC,Leszyk JD,Kenna K,Gall KV,Santos DP,Tischbein M,Funes S,Hayward LJ,Kiskinis E,Landers JE,Parker R,Shaffer SA,Bosco DA

100-11 was used in Cell Culture to suggest that Golgi to ER retrograde transport may be important under conditions of stress and is perturbed upon the expression of disease-linked proteins such as FUS.

Mon Jul 01 00:00:00 EDT 2019

Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in the Subretinal Space of the Cat Eye.

Stem cells and development

Singh RK,Occelli LM,Binette F,Petersen-Jones SM,Nasonkin IO

Sun Sep 01 00:00:00 EDT 2019

Organoid-derived C-Kit⁺/SSEA4^- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents.

Nature communications

Zou T,Gao L,Zeng Y,Li Q,Li Y,Chen S,Hu X,Chen X,Fu C,Xu H,Yin ZQ

Thu Mar 14 00:00:00 EDT 2019

iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds.

Stem cell reports

Faley SL,Neal EH,Wang JX,Bosworth AM,Weber CM,Balotin KM,Lippmann ES,Bellan LM

Tue Mar 05 00:00:00 EST 2019

Metabolism as an early predictor of DPSCs aging.

Scientific reports

Macrin D,Alghadeer A,Zhao YT,Miklas JW,Hussein AM,Detraux D,Robitaille AM,Madan A,Moon RT,Wang Y,Devi A,Mathieu J,Ruohola-Baker H

Mon Feb 18 00:00:00 EST 2019

Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells.

Scientific reports

Gao L,Huang S,Zhang H,Hua W,Xin S,Cheng L,Guan W,Yu Y,Mao Y,Pei G

Tue Mar 05 00:00:00 EST 2019

Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming.

The Journal of biological chemistry

Guo Y,Lei I,Tian S,Gao W,Hacer K,Li Y,Wang S,Liu L,Wang Z

Fri Jun 07 00:00:00 EDT 2019

Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts.

Nature communications

Redd MA,Zeinstra N,Qin W,Wei W,Martinson A,Wang Y,Wang RK,Murry CE,Zheng Y

Mon Feb 04 00:00:00 EST 2019

Structural basis of the activation of type 1 insulin-like growth factor receptor.

Nature communications

Li J,Choi E,Yu H,Bai XC

Tue Oct 08 00:00:00 EDT 2019

Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes.

Translational psychiatry

Patel AM,Wierda K,Thorrez L,van Putten M,De Smedt J,Ribeiro L,Tricot T,Gajjar M,Duelen R,Van Damme P,De Waele L,Goemans N,Tanganyika-de Winter C,Costamagna D,Aartsma-Rus A,van Duyvenvoorde H,Sampaolesi M,Buyse GM,Verfaillie CM

Wed Aug 21 00:00:00 EDT 2019

Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction.

Cell death & disease

Luo X,Jiang X,Li J,Bai Y,Li Z,Wei P,Sun S,Liang Y,Han S,Li X,Zhang B

Thu Jun 06 00:00:00 EDT 2019

A novel epitope-presenting thermostable scaffold for the development of highly specific insulin-like growth factor-1/2 antibodies.

The Journal of biological chemistry

Peeß C,Scholz C,Casagolda D,Düfel H,Gerg M,Kowalewsky F,Bocola M,von Proff L,Goller S,Klöppel-Swarlik H,Hoppe A,Schräml M

Fri Sep 06 00:00:00 EDT 2019

A novel epitope-presenting thermostable scaffold for the development of highly specific insulin-like growth factor-1/2 antibodies.

The Journal of biological chemistry

Peeß C,Scholz C,Casagolda D,Düfel H,Gerg M,Kowalewsky F,Bocola M,von Proff L,Goller S,Klöppel-Swarlik H,Hoppe A,Schräml M

Fri Sep 06 00:00:00 EDT 2019

Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency.

Nature communications

Mathieu J,Detraux D,Kuppers D,Wang Y,Cavanaugh C,Sidhu S,Levy S,Robitaille AM,Ferreccio A,Bottorff T,McAlister A,Somasundaram L,Artoni F,Battle S,Hawkins RD,Moon RT,Ware CB,Paddison PJ,Ruohola-Baker H

Thu Feb 07 00:00:00 EST 2019

IGF-1 facilitates thrombopoiesis primarily through Akt activation.

Blood

Chen S,Hu M,Shen M,Wang S,Wang C,Chen F,Tang Y,Wang X,Zeng H,Chen M,Gao J,Wang F,Su Y,Xu Y,Wang J

Thu Jul 12 00:00:00 EDT 2018

The COPII cargo adapter SEC24C is essential for neuronal homeostasis.

The Journal of clinical investigation

Wang B,Joo JH,Mount R,Teubner BJW,Krenzer A,Ward AL,Ichhaporia VP,Adams EJ,Khoriaty R,Peters ST,Pruett-Miller SM,Zakharenko SS,Ginsburg D,Kundu M

Wed Aug 01 00:00:00 EDT 2018

Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.

The Journal of experimental medicine

Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW

Mon Mar 05 00:00:00 EST 2018

Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis.

EMBO molecular medicine

Youssif C,Cubillos-Rojas M,Comalada M,Llonch E,Perna C,Djouder N,Nebreda AR

100-11 was used in In vivo experiments to determine the role of myeloid insulin-like growth factor-1 downstream of p38α in colitis-associated tumourigenesis.

Sun Jul 01 00:00:00 EDT 2018

The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer.

Cell death and differentiation

Fernandez HR,Gadre SM,Tan M,Graham GT,Mosaoa R,Ongkeko MS,Kim KA,Riggins RB,Parasido E,Petrini I,Pacini S,Cheema A,Varghese R,Ressom HW,Zhang Y,Albanese C,Üren A,Paige M,Giaccone G,Avantaggiati ML

Sun Jul 01 00:00:00 EDT 2018

Repurposing the Cord Blood Bank for Haplobanking of HLA-Homozygous iPSCs and Their Usefulness to Multiple Populations.

Stem cells (Dayton, Ohio)

Lee S,Huh JY,Turner DM,Lee S,Robinson J,Stein JE,Shim SH,Hong CP,Kang MS,Nakagawa M,Kaneko S,Nakanishi M,Rao MS,Kurtz A,Stacey GN,Marsh SGE,Turner ML,Song J

Mon Oct 01 00:00:00 EDT 2018

Striking a new path in reducing cartilage breakdown: combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma.

Journal of cellular and molecular medicine

Riegger J,Joos H,Palm HG,Friemert B,Reichel H,Ignatius A,Brenner RE

Mon Jan 01 00:00:00 EST 2018

Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.

Translational psychiatry

Srikanth P,Lagomarsino VN,Pearse RV,Liao M,Ghosh S,Nehme R,Seyfried N,Eggan K,Young-Pearse TL

Thu Nov 08 00:00:00 EST 2018

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Nature communications

Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II

Tue May 08 00:00:00 EDT 2018

A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors.

Cell reports

Wu J,Matthias N,Lo J,Ortiz-Vitali JL,Shieh AW,Wang SH,Darabi R

100-11 was used in Sample Preparation (FC/FACS) to study myogenic differentiation of human pluripotent stem cells using double-reporter cell resource and defined an improved myogenic differentiation and purification strategy.

Tue Nov 13 00:00:00 EST 2018

Single cell RNA sequencing of stem cell-derived retinal ganglion cells.

Scientific data

Daniszewski M,Senabouth A,Nguyen QH,Crombie DE,Lukowski SW,Kulkarni T,Sluch VM,Jabbari JS,Chamling X,Zack DJ,Pébay A,Powell JE,Hewitt AW

Tue Feb 13 00:00:00 EST 2018

Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents.

PloS one

Southard SM,Kotipatruni RP,Rust WL

100-11 was used in In vitro experiments to show that SR1423 is a candidate cell line for the production of insulin-producing cells useful for the treatment of diabetes.

Thu Feb 21 00:00:00 EST 2019

Loss of GCNT2/I-branched glycans enhances melanoma growth and survival.

Nature communications

Sweeney JG,Liang J,Antonopoulos A,Giovannone N,Kang S,Mondala TS,Head SR,King SL,Tani Y,Brackett D,Dell A,Murphy GF,Haslam SM,Widlund HR,Dimitroff CJ

Wed Aug 22 00:00:00 EDT 2018

Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.

Stem cell reports

Garcia-Alegria E,Menegatti S,Fadlullah MZH,Menendez P,Lacaud G,Kouskoff V

Tue Nov 13 00:00:00 EST 2018

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Scientific reports

MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH

Tue May 22 00:00:00 EDT 2018

Cell death & disease

Birger A,Ottolenghi M,Perez L,Reubinoff B,Behar O

Thu Feb 15 00:00:00 EST 2018

Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts.

Scientific reports

Patel B,Xu Z,Pinnock CB,Kabbani LS,Lam MT

Mon Feb 19 00:00:00 EST 2018

ALCAM⁺ stromal cells: role in giant cell tumor of bone progression.

Cell death & disease

Zhou Z,Li Y,Wang X,Hu J,Kuang M,Wang Z,Li S,Xu W,Xiao J

Tue Feb 20 00:00:00 EST 2018

High-efficiency RNA-based reprogramming of human primary fibroblasts.

Nature communications

Kogut I,McCarthy SM,Pavlova M,Astling DP,Chen X,Jakimenko A,Jones KL,Getahun A,Cambier JC,Pasmooij AMG,Jonkman MF,Roop DR,Bilousova G

Wed Feb 21 00:00:00 EST 2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports

Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E

Tue Oct 09 00:00:00 EDT 2018

hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.

Stem cell reports

Adil MM,Gaj T,Rao AT,Kulkarni RU,Fuentes CM,Ramadoss GN,Ekman FK,Miller EW,Schaffer DV

Tue May 08 00:00:00 EDT 2018

ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer.

Cancer cell

Mahajan K,Malla P,Lawrence HR,Chen Z,Kumar-Sinha C,Malik R,Shukla S,Kim J,Coppola D,Lawrence NJ,Mahajan NP

Mon Jun 12 00:00:00 EDT 2017

A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.

Neuron

Liu Y,Wang X,Li W,Zhang Q,Li Y,Zhang Z,Zhu J,Chen B,Williams PR,Zhang Y,Yu B,Gu X,He Z

Wed Aug 16 00:00:00 EDT 2017

Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.

Oncogene

Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW

Thu Jul 13 00:00:00 EDT 2017

WRN conditioned media is sufficient for in vitro propagation of intestinal organoids from large farm and small companion animals.

Biology open

Powell RH,Behnke MS

100-11 was used in Sample Preparation to investigate organoid development of intestinal crypts.

Mon May 15 00:00:00 EDT 2017

Critical role for arginase 2 in obesity-associated pancreatic cancer.

Nature communications

Zaytouni T,Tsai PY,Hitchcock DS,DuBois CD,Freinkman E,Lin L,Morales-Oyarvide V,Lenehan PJ,Wolpin BM,Mino-Kenudson M,Torres EM,Stylopoulos N,Clish CB,Kalaany NY

Mon Aug 14 00:00:00 EDT 2017

Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production.

Cell death & disease

Zhang M,Wang J,Deng C,Jiang MH,Feng X,Xia K,Li W,Lai X,Xiao H,Ge RS,Gao Y,Xiang AP

Thu Oct 12 00:00:00 EDT 2017

Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia.

Oncotarget

Jiang Z,Wu D,Ye W,Weng J,Lai P,Shi P,Guo X,Huang G,Deng Q,Tang Y,Zhao H,Cui S,Lin S,Wang S,Li B,Wu Q,Li Y,Liu P,Pei D,Du X,Yao Y,Li P

100-11 was used in Cell Culture to develop a defined condition for the ex vivo expansion of primary B-ALL cells that is suitable for high-throughput screening of novel compounds.

Tue Dec 05 00:00:00 EST 2017

In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts.

Stem cell reports

Kadota S,Pabon L,Reinecke H,Murry CE

Tue Feb 14 00:00:00 EST 2017

Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.

Stem cell reports

Muratore CR,Zhou C,Liao M,Fernandez MA,Taylor WM,Lagomarsino VN,Pearse RV,Rice HC,Negri JM,He A,Srikanth P,Callahan DG,Shin T,Zhou M,Bennett DA,Noggle S,Love JC,Selkoe DJ,Young-Pearse TL

Tue Dec 12 00:00:00 EST 2017

Growth factors regulate phospholipid biosynthesis in human fibroblast-like synoviocytes obtained from osteoarthritic knees.

Scientific reports

Sluzalska KD,Liebisch G,Wilhelm J,Ishaque B,Hackstein H,Schmitz G,Rickert M,Steinmeyer J

Wed Oct 18 00:00:00 EDT 2017

Therapeutic potential of human minor salivary gland epithelial progenitor cells in liver regeneration.

Scientific reports

Zhang C,Li Y,Zhang XY,Liu L,Tong HZ,Han TL,Li WD,Jin XL,Yin NB,Song T,Li HD,Zhi J,Zhao ZM,Lu L

Thu Oct 05 00:00:00 EDT 2017

Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.

Nature communications

Rosner M,Pham HTT,Moriggl R,Hengstschläger M

Tue Sep 19 00:00:00 EDT 2017

Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.

Nature communications

Rosner M,Pham HTT,Moriggl R,Hengstschläger M

Tue Sep 19 00:00:00 EDT 2017

Differentiation of Human Induced Pluripotent Stem Cells (iPS Cells) and Embryonic Stem Cells (ES Cells) into Dendritic Cell (DC) Subsets.

Bio-protocol

Sontag S,Förster M,Seré K,Zenke M

100-11 was used in Sample Preparation to study subset specification and function of human dendritic cells (DCs) using a protocol which generates classical cDC1, classical cDC2 and plasmacytoid pDC in vitro from human induced pluripotent stem cells (iPS) cells or ES cells.

Sat Aug 05 00:00:00 EDT 2017

Central IGF1 improves glucose tolerance and insulin sensitivity in mice.

Nutrition & diabetes

Hong H,Cui ZZ,Zhu L,Fu SP,Rossi M,Cui YH,Zhu BM

Tue Dec 19 00:00:00 EST 2017

In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure.

Nature communications

Sittadjody S,Saul JM,McQuilling JP,Joo S,Register TC,Yoo JJ,Atala A,Opara EC

Tue Dec 05 00:00:00 EST 2017

Compartmentalization of Two Cell Types in Multilayered Alginate Microcapsules.

Methods in molecular biology (Clifton, N.J.)

Sittadjody S,Saul JM,Opara EC

100-11 was used in Cell Culture to provide the protocol to compartmentalize two cell types in the same multilayer microcapsules.

Mon Dec 25 00:00:00 EST 2017

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.

Scientific reports

Huang BX,Newcomer K,Kevala K,Barnaeva E,Zheng W,Hu X,Patnaik S,Southall N,Marugan J,Ferrer M,Kim HY

Fri Sep 15 00:00:00 EDT 2017

Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.

Stem cell reports

Rodrigues GMC,Gaj T,Adil MM,Wahba J,Rao AT,Lorbeer FK,Kulkarni RU,Diogo MM,Cabral JMS,Miller EW,Hockemeyer D,Schaffer DV

Tue Jun 06 00:00:00 EDT 2017

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons.

Stem cell reports

Emperador Melero J,Nadadhur AG,Schut D,Weering JV,Heine VM,Toonen RF,Verhage M

Tue Mar 14 00:00:00 EDT 2017

Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Xu Z,Robitaille AM,Berndt JD,Davidson KC,Fischer KA,Mathieu J,Potter JC,Ruohola-Baker H,Moon RT

Tue Oct 18 00:00:00 EDT 2016

Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.

Stem cells translational medicine

Jackson M,Ma R,Taylor AH,Axton RA,Easterbrook J,Kydonaki M,Olivier E,Marenah L,Stanley EG,Elefanty AG,Mountford JC,Forrester LM

100-11 was used in Cell Culture to investigate whether activation of exogenous HOXB4 promotes the production of more mature, definitive red blood cells.

Mon Aug 01 00:00:00 EDT 2016

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.

Stem cells translational medicine

Thorne N,Malik N,Shah S,Zhao J,Class B,Aguisanda F,Southall N,Xia M,McKew JC,Rao M,Zheng W

100-11 was used in Cell Culture to develop as assay to identify compounds that protect against oxidative stress, a condition associated with many neurodegenerative diseases using astrocytes differentiated from human embryonic stem cells.

Sun May 01 00:00:00 EDT 2016

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes.

Stem cells (Dayton, Ohio)

Livesey MR,Magnani D,Cleary EM,Vasistha NA,James OT,Selvaraj BT,Burr K,Story D,Shaw CE,Kind PC,Hardingham GE,Wyllie DJ,Chandran S

Fri Apr 01 00:00:00 EDT 2016

RIG-I inhibits pancreatic β cell proliferation through competitive binding of activated Src.

Scientific reports

Pan Y,Li G,Zhong H,Chen M,Chen T,Gao L,Wu H,Guo J

Tue Jun 28 00:00:00 EDT 2016

Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors.

Stem cell reports

Wen W,Zhang JP,Xu J,Su RJ,Neises A,Ji GZ,Yuan W,Cheng T,Zhang XB

Tue Jun 14 00:00:00 EDT 2016

5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons.

Scientific reports

Wang H,Hu L,Liu C,Su Z,Wang L,Pan G,Guo Y,He J

Wed Feb 03 00:00:00 EST 2016

Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons.

Scientific reports

Zhang WB,Ross PJ,Tu Y,Wang Y,Beggs S,Sengar AS,Ellis J,Salter MW

Mon Apr 04 00:00:00 EDT 2016

ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.

Nature communications

Yamaguchi T,Lu C,Ida L,Yanagisawa K,Usukura J,Cheng J,Hotta N,Shimada Y,Isomura H,Suzuki M,Fujimoto T,Takahashi T

Mon Jan 04 00:00:00 EST 2016

Enriched retinal ganglion cells derived from human embryonic stem cells.

Scientific reports

Gill KP,Hung SS,Sharov A,Lo CY,Needham K,Lidgerwood GE,Jackson S,Crombie DE,Nayagam BA,Cook AL,Hewitt AW,Pébay A,Wong RC

Wed Aug 10 00:00:00 EDT 2016

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs.

Scientific reports

Oleaga C,Bernabini C,Smith AS,Srinivasan B,Jackson M,McLamb W,Platt V,Bridges R,Cai Y,Santhanam N,Berry B,Najjar S,Akanda N,Guo X,Martin C,Ekman G,Esch MB,Langer J,Ouedraogo G,Cotovio J,Breton L,Shuler ML,Hickman JJ

Wed Feb 03 00:00:00 EST 2016

The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction.

Scientific reports

Villalvilla A,García-Martín A,Largo R,Gualillo O,Herrero-Beaumont G,Gómez R

Thu Jul 07 00:00:00 EDT 2016

IGF-1/IGF-1R/hsa-let-7c axis regulates the committed differentiation of stem cells from apical papilla.

Scientific reports

Ma S,Liu G,Jin L,Pang X,Wang Y,Wang Z,Yu Y,Yu J

Fri Nov 11 00:00:00 EST 2016

Empirical inference of circuitry and plasticity in a kinase signaling network.

Proceedings of the National Academy of Sciences of the United States of America

Wilkes EH,Terfve C,Gribben JG,Saez-Rodriguez J,Cutillas PR

Tue Jun 23 00:00:00 EDT 2015

A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach.

Stem cells translational medicine

Chou BK,Gu H,Gao Y,Dowey SN,Wang Y,Shi J,Li Y,Ye Z,Cheng T,Cheng L

100-11 was used in In vitro experiments to derive human induced pluripotent stem cells from blood mononuclear cells under clinically compliant culture conditions.

Wed Apr 01 00:00:00 EDT 2015

Notch signaling regulates motor neuron differentiation of human embryonic stem cells.

Stem cells (Dayton, Ohio)

Ben-Shushan E,Feldman E,Reubinoff BE

Sun Feb 01 00:00:00 EST 2015

Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system.

Stem cells (Dayton, Ohio)

Denham M,Hasegawa K,Menheniott T,Rollo B,Zhang D,Hough S,Alshawaf A,Febbraro F,Ighaniyan S,Leung J,Elliott DA,Newgreen DF,Pera MF,Dottori M

Mon Jun 01 00:00:00 EDT 2015

Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Ramos-Amaya A,Rodríguez-Bayona B,López-Blanco R,Andújar E,Pérez-Alegre M,Campos-Caro A,Brieva JA

Sun Feb 01 00:00:00 EST 2015

Targeting lung cancer stem-like cells with TRAIL gene armed oncolytic adenovirus.

Journal of cellular and molecular medicine

Yang Y,Xu H,Huang W,Ding M,Xiao J,Yang D,Li H,Liu XY,Chu L

Fri May 01 00:00:00 EDT 2015

Insulin-Like Growth Factor-Independent Effects of Growth Hormone on Growth Plate Chondrogenesis and Longitudinal Bone Growth.

Endocrinology

Wu S,Yang W,De Luca F

100-11 was used in In vivo experiments to study whether GH has IGF-independent growth-promoting effects using (TamCart)Igf1r(flox/flox) mice models to demonstrate that GH can promote growth plate chondrogenesis and longitudinal bone growth directly at the growth plate, even when the local effects of IGF-1 and IGF-2 are prevented.

Wed Jul 01 00:00:00 EDT 2015

Role of sox9 in growth factor regulation of articular chondrocytes.

Journal of cellular biochemistry

Shi S,Wang C,Acton AJ,Eckert GJ,Trippel SB

Wed Jul 01 00:00:00 EDT 2015

RGD-modifided oncolytic adenovirus exhibited potent cytotoxic effect on CAR-negative bladder cancer-initiating cells.

Cell death & disease

Yang Y,Xu H,Shen J,Yang Y,Wu S,Xiao J,Xu Y,Liu XY,Chu L

Thu May 14 00:00:00 EDT 2015

Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.

Scientific reports

Wang S,Wang B,Pan N,Fu L,Wang C,Song G,An J,Liu Z,Zhu W,Guan Y,Xu ZQ,Chan P,Chen Z,Zhang YA

Wed Mar 18 00:00:00 EDT 2015

Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.

Scientific reports

Wang S,Wang B,Pan N,Fu L,Wang C,Song G,An J,Liu Z,Zhu W,Guan Y,Xu ZQ,Chan P,Chen Z,Zhang YA

Wed Mar 18 00:00:00 EDT 2015

A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells.

The Journal of biological chemistry

Xiao H,Bid HK,Jou D,Wu X,Yu W,Li C,Houghton PJ,Lin J

Fri Feb 06 00:00:00 EST 2015

Optimizing culture medium composition to improve oligodendrocyte progenitor cell yields in vitro from subventricular zone-derived neural progenitor cell neurospheres.

PloS one

Franco PG,Pasquini JM,Silvestroff L

100-11 was used in Cell Culture to study cell proliferation and OPC yield using Subventricular Zone-derived NSC/NPC primary cultures from newborn mice and studying the effects of different growth factor combinations on the. The Platelet Derived Growth Factor-AA and BB homodimers had a positive and significant impact on OPC generation. The OPC generated by this protocol were able to mature into Myelin Basic Protein-expressing cells, thus proposing an optimized in vitro method for increasing OPC.

Thu Mar 31 00:00:00 EDT 2016

SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway.

Scientific reports

Han K,Xu X,Xu Z,Chen G,Zeng Y,Zhang Z,Cao B,Kong Y,Tang X,Mao X

Wed Sep 02 00:00:00 EDT 2015

Spinal muscular atrophy phenotype is ameliorated in human motor neurons by SMN increase via different novel RNA therapeutic approaches.

Scientific reports

Nizzardo M,Simone C,Dametti S,Salani S,Ulzi G,Pagliarani S,Rizzo F,Frattini E,Pagani F,Bresolin N,Comi G,Corti S

Tue Jun 30 00:00:00 EDT 2015

The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells.

Scientific reports

Boisvert EM,Engle SJ,Hallowell SE,Liu P,Wang ZW,Li XJ

Thu Nov 19 00:00:00 EST 2015

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer.

Oncotarget

Chang J,Wang S,Zhang Z,Liu X,Wu Z,Geng R,Ge X,Dai C,Liu R,Zhang Q,Li W,Li J

Tue Feb 10 00:00:00 EST 2015

Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.

Nature communications

Adams KL,Rousso DL,Umbach JA,Novitch BG

Tue Apr 14 00:00:00 EDT 2015

Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.

Scientific reports

Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP

Mon Nov 09 00:00:00 EST 2015

Insulin-like growth factor 1 (IGF-1) stabilizes nascent blood vessels.

The Journal of biological chemistry

Jacobo SM,Kazlauskas A

Fri Mar 06 00:00:00 EST 2015

Phenotypic and functional characterization of long-term cryopreserved human adipose-derived stem cells.

Scientific reports

Yong KW,Pingguan-Murphy B,Xu F,Abas WA,Choi JR,Omar SZ,Azmi MA,Chua KH,Wan Safwani WK

Wed Apr 15 00:00:00 EDT 2015

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.

Nature

Chong JJ,Yang X,Don CW,Minami E,Liu YW,Weyers JJ,Mahoney WM,Van Biber B,Cook SM,Palpant NJ,Gantz JA,Fugate JA,Muskheli V,Gough GM,Vogel KW,Astley CA,Hotchkiss CE,Baldessari A,Pabon L,Reinecke H,Gill EA,Nelson V,Kiem HP,Laflamme MA,Murry CE

Thu Jun 12 00:00:00 EDT 2014

Chemically defined generation of human cardiomyocytes.

Nature methods

Burridge PW,Matsa E,Shukla P,Lin ZC,Churko JM,Ebert AD,Lan F,Diecke S,Huber B,Mordwinkin NM,Plews JR,Abilez OJ,Cui B,Gold JD,Wu JC

Fri Aug 01 00:00:00 EDT 2014

Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.

Cell research

Jiang MH,Cai B,Tuo Y,Wang J,Zang ZJ,Tu X,Gao Y,Su Z,Li W,Li G,Zhang M,Jiao J,Wan Z,Deng C,Lahn BT,Xiang AP

Mon Dec 01 00:00:00 EST 2014

Leukemia propagating cells rebuild an evolving niche in response to therapy.

Cancer cell

Duan CW,Shi J,Chen J,Wang B,Yu YH,Qin X,Zhou XC,Cai YJ,Li ZQ,Zhang F,Yin MZ,Tao Y,Mi JQ,Li LH,Enver T,Chen GQ,Hong DL

Mon Jun 16 00:00:00 EDT 2014

Human glial chimeric mice reveal astrocytic dependence of JC virus infection.

The Journal of clinical investigation

Kondo Y,Windrem MS,Zou L,Chandler-Militello D,Schanz SJ,Auvergne RM,Betstadt SJ,Harrington AR,Johnson M,Kazarov A,Gorelik L,Goldman SA

Mon Dec 01 00:00:00 EST 2014

Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Castro J,Garcia RI,Kwok S,Banerjee A,Petravicz J,Woodson J,Mellios N,Tropea D,Sur M

Tue Jul 08 00:00:00 EDT 2014

β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Mellios N,Woodson J,Garcia RI,Crawford B,Sharma J,Sheridan SD,Haggarty SJ,Sur M

Tue Jul 08 00:00:00 EDT 2014

Ampelopsin-induced autophagy protects breast cancer cells from apoptosis through Akt-mTOR pathway via endoplasmic reticulum stress.

Cancer science

Zhou Y,Liang X,Chang H,Shu F,Wu Y,Zhang T,Fu Y,Zhang Q,Zhu JD,Mi M

Wed Oct 01 00:00:00 EDT 2014

Maintenance and neuronal differentiation of chicken induced pluripotent stem-like cells.

Stem cells international

Dai R,Rossello R,Chen CC,Kessler J,Davison I,Hochgeschwender U,Jarvis ED

100-11 was used in Cell Culture to demonstrate an efficient method of maintaining chicken induced pluripotent stem (iPSC)-like cells and for differentiating them into action potential generating neurons.

Thu Jan 22 00:00:00 EST 2015

GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4.

The Journal of biological chemistry

Huo X,Liu S,Shao T,Hua H,Kong Q,Wang J,Luo T,Jiang Y

Fri Sep 05 00:00:00 EDT 2014

Derivation of novel human ground state naive pluripotent stem cells.

Nature

Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH

Thu Dec 12 00:00:00 EST 2013

Derivation of novel human ground state naive pluripotent stem cells.

Nature

Thu Dec 12 00:00:00 EST 2013

Analysis of FOXO1 mutations in diffuse large B-cell lymphoma.

Blood

Trinh DL,Scott DW,Morin RD,Mendez-Lago M,An J,Jones SJ,Mungall AJ,Zhao Y,Schein J,Steidl C,Connors JM,Gascoyne RD,Marra MA

Thu May 02 00:00:00 EDT 2013

Ephrin-B2 controls PDGFRβ internalization and signaling.

Genes & development

Nakayama A,Nakayama M,Turner CJ,Höing S,Lepore JJ,Adams RH

100-11 was used in Cell Culture to show that ephrin-B2 is an important regulator of PDGFRβ endocytosis, acting as a molecular switch controlling the downstream signaling activity of this receptor in mural cells.

Sun Dec 01 00:00:00 EST 2013

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.

Proceedings of the National Academy of Sciences of the United States of America

Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA

Tue Mar 19 00:00:00 EDT 2013

STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.

Journal of immunology (Baltimore, Md. : 1950)

Rodríguez-Bayona B,Ramos-Amaya A,López-Blanco R,Campos-Caro A,Brieva JA

Fri Nov 15 00:00:00 EST 2013

A crayfish insulin-like-binding protein: another piece in the androgenic gland insulin-like hormone puzzle is revealed.

The Journal of biological chemistry

Rosen O,Weil S,Manor R,Roth Z,Khalaila I,Sagi A

Fri Aug 02 00:00:00 EDT 2013

Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators.

Journal of neuroinflammation

Suh HS,Zhao ML,Derico L,Choi N,Lee SC

100-11 was used in Cell Culture to suggest that chronic neuroinflammation and upregulation of proinflammatory cytokines could lead to neurodegeneration by suppressing the production of microglia-derived neuronal growth factors, such as IGF1.

Tue Mar 12 00:00:00 EDT 2013

Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.

PloS one

McNamara CR,Ahuja R,Osafo-Addo AD,Barrows D,Kettenbach A,Skidan I,Teng X,Cuny GD,Gerber S,Degterev A

Tue Aug 27 00:00:00 EDT 2013

Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts.

Nature

Shiba Y,Fernandes S,Zhu WZ,Filice D,Muskheli V,Kim J,Palpant NJ,Gantz J,Moyes KW,Reinecke H,Van Biber B,Dardas T,Mignone JL,Izawa A,Hanna R,Viswanathan M,Gold JD,Kotlikoff MI,Sarvazyan N,Kay MW,Murry CE,Laflamme MA

Thu Sep 13 00:00:00 EDT 2012

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

Nature

Wilson TR,Fridlyand J,Yan Y,Penuel E,Burton L,Chan E,Peng J,Lin E,Wang Y,Sosman J,Ribas A,Li J,Moffat J,Sutherlin DP,Koeppen H,Merchant M,Neve R,Settleman J

Thu Jul 26 00:00:00 EDT 2012

Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression.

Nature protocols

Dowey SN,Huang X,Chou BK,Ye Z,Cheng L

100-11 was used in Cell Culture to describe a detailed, validated protocol for effective generation of integration-free human induced pluripotent stem cells from blood mononuclear cells by plasmid vectors.

Thu Nov 01 00:00:00 EDT 2012

2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen.

The Journal of cell biology

Meyer AS,Hughes-Alford SK,Kay JE,Castillo A,Wells A,Gertler FB,Lauffenburger DA

Mon Jun 11 00:00:00 EDT 2012

Pharmacological modulation of human mesenchymal stem cell chondrogenesis by a chemically oversulfated polysaccharide of marine origin: potential application to cartilage regenerative medicine.

Stem cells (Dayton, Ohio)

Merceron C,Portron S,Vignes-Colombeix C,Rederstorff E,Masson M,Lesoeur J,Sourice S,Sinquin C,Colliec-Jouault S,Weiss P,Vinatier C,Guicheux J

Thu Mar 01 00:00:00 EST 2012

ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes.

Disease models & mechanisms

Bitar MS,Al-Mulla F

Tue May 01 00:00:00 EDT 2012

Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain.

Stem cells international

Nakaguchi K,Jinnou H,Kaneko N,Sawada M,Hikita T,Saitoh S,Tabata Y,Sawamoto K

Thu Oct 25 00:00:00 EDT 2012

Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics.

PloS one

Ferro F,Spelat R,D'Aurizio F,Puppato E,Pandolfi M,Beltrami AP,Cesselli D,Falini G,Beltrami CA,Curcio F

Wed Nov 28 00:00:00 EST 2012

Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells.

The Journal of biological chemistry

Sarfstein R,Pasmanik-Chor M,Yeheskel A,Edry L,Shomron N,Warman N,Wertheimer E,Maor S,Shochat L,Werner H

Fri Jan 20 00:00:00 EST 2012

Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).

The Journal of biological chemistry

Palsgaard J,Emanuelli B,Winnay JN,Sumara G,Karsenty G,Kahn CR

Fri Apr 06 00:00:00 EDT 2012

Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors.

PloS one

Kawamura K,Chen Y,Shu Y,Cheng Y,Qiao J,Behr B,Pera RA,Hsueh AJ

Tue May 07 00:00:00 EDT 2013

In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells.

PloS one

Sakurai H,Sakaguchi Y,Shoji E,Nishino T,Maki I,Sakai H,Hanaoka K,Kakizuka A,Sehara-Fujisawa A

Tue Apr 23 00:00:00 EDT 2013

In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells.

PloS one

Sakurai H,Sakaguchi Y,Shoji E,Nishino T,Maki I,Sakai H,Hanaoka K,Kakizuka A,Sehara-Fujisawa A

Tue Apr 23 00:00:00 EDT 2013

Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation.

Skeletal muscle

Bernacchioni C,Cencetti F,Blescia S,Donati C,Bruni P

Thu Jul 12 00:00:00 EDT 2012

Phase contrast microscopy of living cells within the whole lens: spatial correlations and morphological dynamics.

Molecular vision

Kong Z,Zhu X,Zhang S,Wu J,Luo Y

Fri Dec 21 00:00:00 EST 2012

Differential regulation of bone marrow-derived endothelial progenitor cells and endothelial outgrowth cells by the Notch signaling pathway.

PloS one

Chen JY,Feng L,Zhang HL,Li JC,Yang XW,Cao XL,Liu L,Qin HY,Liang YM,Han H

Thu May 09 00:00:00 EDT 2013

Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.

PloS one

Bill A,Schmitz A,König K,Heukamp LC,Hannam JS,Famulok M

Wed Jan 16 00:00:00 EST 2013

A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells.

Sarcoma

van Valen F,Harrer H,Hotfilder M,Dirksen U,Pap T,Gosheger G,Humpf HU,Jürgens H

Wed Oct 24 00:00:00 EDT 2012

The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.

Cancer cell

Chang CY,Kazmin D,Jasper JS,Kunder R,Zuercher WJ,McDonnell DP

Tue Oct 18 00:00:00 EDT 2011

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

Blood

Mao X,Cao B,Wood TE,Hurren R,Tong J,Wang X,Wang W,Li J,Jin Y,Sun W,Spagnuolo PA,MacLean N,Moran MF,Datti A,Wrana J,Batey RA,Schimmer AD

Thu Feb 10 00:00:00 EST 2011

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

Blood

Mao X,Cao B,Wood TE,Hurren R,Tong J,Wang X,Wang W,Li J,Jin Y,Sun W,Spagnuolo PA,MacLean N,Moran MF,Datti A,Wrana J,Batey RA,Schimmer AD

Thu Feb 10 00:00:00 EST 2011

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.

The Journal of clinical investigation

Wu X,Simpson J,Hong JH,Kim KH,Thavarajah NK,Backx PH,Neel BG,Araki T

Tue Mar 01 00:00:00 EST 2011

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.

The Journal of experimental medicine

Medyouf H,Gusscott S,Wang H,Tseng JC,Wai C,Nemirovsky O,Trumpp A,Pflumio F,Carboni J,Gottardis M,Pollak M,Kung AL,Aster JC,Holzenberger M,Weng AP

Mon Aug 29 00:00:00 EDT 2011

Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells.

Stem cells (Dayton, Ohio)

Alva JA,Lee GE,Escobar EE,Pyle AD

Thu Dec 01 00:00:00 EST 2011

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation.

Human molecular genetics

Cheung AY,Horvath LM,Grafodatskaya D,Pasceri P,Weksberg R,Hotta A,Carrel L,Ellis J

Wed Jun 01 00:00:00 EDT 2011

Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I.

International journal of cell biology

Morimura S,Takahashi K

Thu Nov 10 00:00:00 EST 2011

Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.

Molecular cancer

Zhao M,Ma J,Zhu HY,Zhang XH,Du ZY,Xu YJ,Yu XD

Mon Aug 29 00:00:00 EDT 2011

Directed differentiation of dopamine neurons from human pluripotent stem cells.

Methods in molecular biology (Clifton, N.J.)

Ma L,Liu Y,Zhang SC

100-11 was used in Cell Culture to describe a chemically defined protocol for mDA neuron differentiation.

Thu Nov 24 00:00:00 EST 2011

The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway.

PloS one

Sarfstein R,Bruchim I,Fishman A,Werner H

Fri Jun 08 00:00:00 EDT 2012

The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.

The Journal of biological chemistry

Chen CH,Sarbassov dos D

Fri Nov 18 00:00:00 EST 2011

Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells.

The Journal of biological chemistry

Hernández-Varas P,Coló GP,Bartolomé RA,Paterson A,Medraño-Fernández I,Arellano-Sánchez N,Cabañas C,Sánchez-Mateos P,Lafuente EM,Boussiotis VA,Strömblad S,Teixidó J

Fri May 27 00:00:00 EDT 2011

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.

Cell

Marchetto MC,Carromeu C,Acab A,Yu D,Yeo GW,Mu Y,Chen G,Gage FH,Muotri AR

Fri Nov 12 00:00:00 EST 2010

GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death.

Blood

Streetly MJ,Maharaj L,Joel S,Schey SA,Gribben JG,Cotter FE

Thu May 13 00:00:00 EDT 2010

Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.

Blood

Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H

Thu Dec 02 00:00:00 EST 2010

Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture.

Angiogenesis

Trapp V,Parmakhtiar B,Papazian V,Willmott L,Fruehauf JP

Wed Dec 01 00:00:00 EST 2010

Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function.

Stem cells (Dayton, Ohio)

Sordi V,Melzi R,Mercalli A,Formicola R,Doglioni C,Tiboni F,Ferrari G,Nano R,Chwalek K,Lammert E,Bonifacio E,Borg D,Piemonti L

Fri Jan 01 00:00:00 EST 2010

Membrane-based cultures generate scaffold-free neocartilage in vitro: influence of growth factors.

Tissue engineering. Part A

Mayer-Wagner S,Schiergens TS,Sievers B,Docheva D,Schieker M,Betz OB,Jansson V,Müller PE

Mon Feb 01 00:00:00 EST 2010

Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

The Journal of biological chemistry

McMahon M,Ayllón V,Panov KI,O'Connor R

Fri Jun 11 00:00:00 EDT 2010

Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells.

PloS one

Zeng H,Guo M,Martins-Taylor K,Wang X,Zhang Z,Park JW,Zhan S,Kronenberg MS,Lichtler A,Liu HX,Chen FP,Yue L,Li XJ,Xu RH

Thu Jul 29 00:00:00 EDT 2010

Characterization of a human fetal spinal cord stem cell line, NSI-566RSC, and its induction to functional motoneurons.

Journal of tissue engineering and regenerative medicine

Guo X,Johe K,Molnar P,Davis H,Hickman J

100-11 was used in In vitro experiments to report the first successful differentiation of MNs from human spinal cord stem cells in vitro, providing a novel approach for obtaining functional MNs when designing the therapeutic strategy for spinal cord diseases or injuries.

Mon Mar 01 00:00:00 EST 2010

A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.

PloS one

Berenguer M,Martinez L,Giorgetti-Peraldi S,Le Marchand-Brustel Y,Govers R

Mon Dec 20 00:00:00 EST 2010

Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.

The Journal of biological chemistry

O'Callaghan KM,Ayllon V,O'Keeffe J,Wang Y,Cox OT,Loughran G,Forgac M,O'Connor R

Fri Jan 01 00:00:00 EST 2010

Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.

The Journal of biological chemistry

Leenders JJ,Wijnen WJ,Hiller M,van der Made I,Lentink V,van Leeuwen REW,Herias V,Pokharel S,Heymans S,de Windt LJ,Høydal MA,Pinto YM,Creemers EE

Fri Aug 27 00:00:00 EDT 2010

Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death.

The Journal of biological chemistry

Alberobello AT,D'Esposito V,Marasco D,Doti N,Ruvo M,Bianco R,Tortora G,Esposito I,Fiory F,Miele C,Beguinot F,Formisano P

Fri Feb 26 00:00:00 EST 2010

Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes.

Molecular & cellular proteomics : MCP

Alexopoulos LG,Saez-Rodriguez J,Cosgrove BD,Lauffenburger DA,Sorger PK

Wed Sep 01 00:00:00 EDT 2010

The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling.

The Journal of biological chemistry

Li M,Yin Y,Hua H,Sun X,Luo T,Wang J,Jiang Y

Fri Oct 01 00:00:00 EDT 2010

Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation.

Blood

Zhang J,Randall MS,Loyd MR,Dorsey FC,Kundu M,Cleveland JL,Ney PA

Thu Jul 02 00:00:00 EDT 2009

Differentiation of human oligodendrocytes from pluripotent stem cells.

Nature protocols

Hu BY,Du ZW,Zhang SC

Wed Jan 06 00:00:00 EST 2010

Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue.

Proceedings of the National Academy of Sciences of the United States of America

Stevens KR,Kreutziger KL,Dupras SK,Korte FS,Regnier M,Muskheli V,Nourse MB,Bendixen K,Reinecke H,Murry CE

Tue Sep 29 00:00:00 EDT 2009

Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma.

The Journal of clinical endocrinology and metabolism

Barlaskar FM,Spalding AC,Heaton JH,Kuick R,Kim AC,Thomas DG,Giordano TJ,Ben-Josef E,Hammer GD

Thu Jan 01 00:00:00 EST 2009

Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Griffiths MR,Neal JW,Fontaine M,Das T,Gasque P

Wed Apr 01 00:00:00 EDT 2009

Insulin-like growth factor-I and slow, bi-directional perfusion enhance the formation of tissue-engineered cardiac grafts.

Tissue engineering. Part A

Cheng M,Moretti M,Engelmayr GC,Freed LE

Sun Mar 01 00:00:00 EST 2009

Evidence for in vivo growth potential and vascular remodeling of tissue-engineered artery.

Tissue engineering. Part A

Cho SW,Kim IK,Kang JM,Song KW,Kim HS,Park CH,Yoo KJ,Kim BS

Wed Apr 01 00:00:00 EDT 2009

Development of serum-free, chemically defined conditions for human embryonic stem cell-derived fibrochondrogenesis.

Tissue engineering. Part A

Koay EJ,Athanasiou KA

Sat Aug 01 00:00:00 EDT 2009

Streptococcus agalactiae CspA is a serine protease that inactivates chemokines.

Journal of bacteriology

Bryan JD,Shelver DW

Sun Mar 01 00:00:00 EST 2009

SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression.

The Journal of biological chemistry

Tai DJ,Su CC,Ma YL,Lee EH

Fri Feb 13 00:00:00 EST 2009

The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors.

The Journal of biological chemistry

Essaghir A,Dif N,Marbehant CY,Coffer PJ,Demoulin JB

Fri Apr 17 00:00:00 EDT 2009

A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase.

PloS one

Wu D,Pang Y,Ke Y,Yu J,He Z,Tautz L,Mustelin T,Ding S,Huang Z,Feng GS

Thu May 28 00:00:00 EDT 2009

Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells.

Fibrogenesis & tissue repair

Gentilini A,Lottini B,Brogi M,Caligiuri A,Cosmi L,Marra F,Pinzani M

Fri Jan 30 00:00:00 EST 2009

Growth factor regulation of growth factors in articular chondrocytes.

The Journal of biological chemistry

Shi S,Mercer S,Eckert GJ,Trippel SB

Fri Mar 13 00:00:00 EDT 2009

Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.

Molecular systems biology

Saez-Rodriguez J,Alexopoulos LG,Epperlein J,Samaga R,Lauffenburger DA,Klamt S,Sorger PK

Thu Apr 01 00:00:00 EDT 2010

Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

Molecular systems biology

Borisov N,Aksamitiene E,Kiyatkin A,Legewie S,Berkhout J,Maiwald T,Kaimachnikov NP,Timmer J,Hoek JB,Kholodenko BN

Fri Jun 26 00:00:00 EDT 2009

Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain.

Proceedings of the National Academy of Sciences of the United States of America

Kohyama J,Kojima T,Takatsuka E,Yamashita T,Namiki J,Hsieh J,Gage FH,Namihira M,Okano H,Sawamoto K,Nakashima K

Tue Nov 18 00:00:00 EST 2008

Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells.

BMC cell biology

Kretlow JD,Jin YQ,Liu W,Zhang WJ,Hong TH,Zhou G,Baggett LS,Mikos AG,Cao Y

Tue Oct 28 00:00:00 EDT 2008

Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.

The Journal of biological chemistry

Lindemann MJ,Hu Z,Benczik M,Liu KD,Gaffen SL

Fri May 16 00:00:00 EDT 2008

The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.

Stem cells (Dayton, Ohio)

Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J

Sun Jul 01 00:00:00 EDT 2007

A comparative analysis of cartilage engineered from different perinatal mesenchymal progenitor cells.

Tissue engineering

Kunisaki SM,Fuchs JR,Steigman SA,Fauza DO

Thu Nov 01 00:00:00 EDT 2007

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype.

Genes & development

Murakami S,Balmes G,McKinney S,Zhang Z,Givol D,de Crombrugghe B

Sun Feb 01 00:00:00 EST 2004

Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2.

Journal of immunology (Baltimore, Md. : 1950)

Hartnell A,Heinemann A,Conroy DM,Wait R,Sturm GJ,Caversaccio M,Jose PJ,Williams TJ

Mon Nov 15 00:00:00 EST 2004

Growth factors regulate phototransduction in retinal rods by modulating cyclic nucleotide-gated channels through dephosphorylation of a specific tyrosine residue.

Proceedings of the National Academy of Sciences of the United States of America

Savchenko A,Kraft TW,Molokanova E,Kramer RH

Tue May 08 00:00:00 EDT 2001

Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hanson MG,Shen S,Wiemelt AP,McMorris FA,Barres BA

Tue Sep 15 00:00:00 EDT 1998

Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures.

The Journal of physiology

Liou JC,Yang RS,Fu WM

Fri Aug 15 00:00:00 EDT 1997

Heparin binding and oligomerization of hepatocyte growth factor/scatter factor isoforms. Heparan sulfate glycosaminoglycan requirement for Met binding and signaling.

The Journal of biological chemistry

Sakata H,Stahl SJ,Taylor WG,Rosenberg JM,Sakaguchi K,Wingfield PT,Rubin JS

100-11 was used in Cell Culture to establish the importance of the N domain for heparin-ligand and ligand-ligand interactions, and demonstrate a crucial role for HSGAG in receptor binding and signal transduction.

Fri Apr 04 00:00:00 EST 1997

Bioinformatics

Protein Aliases: H-IGF-1; IGF; IGF-I; IGF-IA; IGF-IB; IGF1A; IGFIa; Insulin like growth factor; insulin-like growth factor 1 (somatomedin C); Insulin-like growth factor I; insulin-like growth factor IB; M-IGF-1; Mechano growth factor; MGF; OTTHUMP00000195084; R-IGF-1; Somatomedin C; Somatomedin-C

Human IGF-I Recombinant Protein, PeproTech®

Human IGF-I Protein (100-11-500UG) in Functional

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100-11-500UG

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