Gibco

Human IL-1 beta Recombinant Protein, PeproTech®

Human IL-1 beta Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Human IL-1 beta Protein (200-01B-10UG) in Functional

Bioassay analysis of Human IL-1 beta Recombinant Protein, PeproTech® (Product # 200-01B-1MG).

Product Image Gallery

Product Details

200-01B-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 5 publications 5 publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 404 publications 404 publications

Miscellaneous PubMed (Misc)

View 39 publications 39 publications

Product Specifications

Species

Human

Published species

Bacteria, Bovine, Hamster, Horse, Human, Mouse, Non-human primate, Pig, Rabbit, Rat, Sheep

Expression System

E. coli

Amino acid sequence

APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS

Molecular weight

17.3 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 10^9 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

200-01B-1MG will be provided as 2 x 500 µg (200-01B-500UG).

Recombinant Human IL-1beta is a 17.3 kDa protein containing 153 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion.

Cell death & disease

Capuz A,Osien S,Karnoub MA,Aboulouard S,Laurent E,Coyaud E,Raffo-Romero A,Duhamel M,Bonnefond A,Derhourhi M,Trerotola M,El Yazidi-Belkoura I,Devos D,Zilkova M,Kobeissy F,Vanden Abeele F,Fournier I,Cizkova D,Rodet F,Salzet M

200-01B was used in In vitro experiments to demonstrate that these chains are synthesized individually and associated to recognize specific targets.

Tue Apr 04 00:00:00 EDT 2023

The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion.

PLoS pathogens

Wang S,Moreau F,Chadee K

200-01B was used in In vitro experiments to investigate pro-inflammatory cytokine secretion following Entamoeba histolytica infection.

Tue Mar 01 00:00:00 EST 2022

Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration.

Oxidative medicine and cellular longevity

Li Y,Wu X,Li J,Du L,Wang X,Cao J,Li H,Huo Z,Li G,Pan D,Xu H,Xu B

Fri Mar 04 00:00:00 EST 2022

Anti-apoptotic effects of human gingival mesenchymal stromal cells on polymorphonuclear leucocytes.

Oral diseases

Blufstein A,Behm C,Kubin B,Gahn J,Moritz A,Rausch-Fan X,Andrukhov O

Fri Apr 01 00:00:00 EDT 2022

Plasmodium falciparum and TNF-α Differentially Regulate Inflammatory and Barrier Integrity Pathways in Human Brain Endothelial Cells.

mBio

Zuniga M,Gomes C,Chen Z,Martinez C,Devlin JC,Loke P,Rodriguez A

200-01B was used in Sample Preparation (FC/FACS) to investigate TNF-α regulation of cerebral malaria infection across the blood-brain barrier.

Wed Oct 26 00:00:00 EDT 2022

Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression.

Frontiers in immunology

Wang H,Xie L,Song X,Wang J,Li X,Lin Z,Su T,Liang B,Huang D

200-01B was used in Cell Culture to explore whether exogenous purines are responsible for increased xanthine oxidoreductase expression and activity.

Thu Mar 03 00:00:00 EST 2022

Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.

Cell reports

Li Y,Zhu Y,Feng S,Ishida Y,Chiu TP,Saito T,Wang S,Ann DK,Ou JJ

200-01B was used in In vitro on human Huh7 cells

Tue Jan 25 00:00:00 EST 2022

JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.

JCI insight

Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA

200-01B was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.

Wed Jun 08 00:00:00 EDT 2022

Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.

JID innovations : skin science from molecules to population health

Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH

200-01B was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.

Sat Jan 01 00:00:00 EST 2022

Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer.

Cancers

Baram T,Oren N,Erlichman N,Meshel T,Ben-Baruch A

200-01B was used in In vitro experiments to suggest that in addition to its immune-suppressive activities, PD-L1 may promote disease course in TNBC by inhibiting the protective effects of sTNFR1 and sTNFR2.

Tue Jul 19 00:00:00 EDT 2022

TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1.

Aging cell

Kandhaya-Pillai R,Yang X,Tchkonia T,Martin GM,Kirkland JL,Oshima J

200-01B was used in In vitro experiments to find exposure of human umbilical vein endothelial cells (HUVECs) to the inflammatory cytokines, TNF-α + IFN-γ or a cocktail of TNF-α + IFN-γ + IL-6, increased expression of ACE2/DPP4, accentuated the pro-inflammatory senescence-associated secretory phenotype (SASP), and decreased cellular proliferative capacity, consistent with progression towards a cellular senescence-like state.

Wed Jun 01 00:00:00 EDT 2022

A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells.

Cell discovery

Karpf L,Trichot C,Faucheux L,Legbre I,Grandclaudon M,Lahoute C,Mattoo H,Pasquier B,Soumelis V

Tue Jan 04 00:00:00 EST 2022

Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.

Viruses

Cruz-Lorenzo E,Ramirez NP,Lee J,Pandhe S,Wang L,Hernandez-Doria J,Spivak AM,Planelles V,Petersen T,Jain MK,Martinez ED,D'Orso I

200-01B was used in Cell Culture to suggest that manipulation of redox-sensitive pathways could be exploited to alter the course of HIV-1 latency, thus rendering host cells responsive to help achieve a sterilizing cure.

Tue Oct 18 00:00:00 EDT 2022

Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.

Cellular and molecular gastroenterology and hepatology

Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR

200-01B was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.

Mon Apr 04 00:00:00 EDT 2022

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia.

Life science alliance

Amatngalim GD,Rodenburg LW,Aalbers BL,Raeven HH,Aarts EM,Sarhane D,Spelier S,Lefferts JW,Silva IA,Nijenhuis W,Vrendenbarg S,Kruisselbrink E,Brunsveld JE,van Drunen CM,Michel S,de Winter-de Groot KM,Heijerman HG,Kapitein LC,Amaral MD,van der Ent CK,Beekman JM

200-01B was used in Cell Culture to define organoid culture conditions, with the growth factor/cytokine combination neuregulin-1lt;igt;βlt;/igt; and interleukin-1lt;igt;βlt;/igt;, which enabled consistent detection of CFTR modulator responses in nasal-airway organoid cultures from subjects with cystic fibrosis.

Wed Aug 03 00:00:00 EDT 2022

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.

Cell

Mills RJ,Humphrey SJ,Fortuna PRJ,Lor M,Foster SR,Quaife-Ryan GA,Johnston RL,Dumenil T,Bishop C,Rudraraju R,Rawle DJ,Le T,Zhao W,Lee L,Mackenzie-Kludas C,Mehdiabadi NR,Halliday C,Gilham D,Fu L,Nicholls SJ,Johansson J,Sweeney M,Wong NCW,Kulikowski E,Sokolowski KA,Tse BWC,Devilée L,Voges HK,Reynolds LT,Krumeich S,Mathieson E,Abu-Bonsrah D,Karavendzas K,Griffen B,Titmarsh D,Elliott DA,McMahon J,Suhrbier A,Subbarao K,Porrello ER,Smyth MJ,Engwerda CR,MacDonald KPA,Bald T,James DE,Hudson JE

Thu Apr 15 00:00:00 EDT 2021

Spatially organized multicellular immune hubs in human colorectal cancer.

Cell

Pelka K,Hofree M,Chen JH,Sarkizova S,Pirl JD,Jorgji V,Bejnood A,Dionne D,Ge WH,Xu KH,Chao SX,Zollinger DR,Lieb DJ,Reeves JW,Fuhrman CA,Hoang ML,Delorey T,Nguyen LT,Waldman J,Klapholz M,Wakiro I,Cohen O,Albers J,Smillie CS,Cuoco MS,Wu J,Su MJ,Yeung J,Vijaykumar B,Magnuson AM,Asinovski N,Moll T,Goder-Reiser MN,Applebaum AS,Brais LK,DelloStritto LK,Denning SL,Phillips ST,Hill EK,Meehan JK,Frederick DT,Sharova T,Kanodia A,Todres EZ,Jané-Valbuena J,Biton M,Izar B,Lambden CD,Clancy TE,Bleday R,Melnitchouk N,Irani J,Kunitake H,Berger DL,Srivastava A,Hornick JL,Ogino S,Rotem A,Vigneau S,Johnson BE,Corcoran RB,Sharpe AH,Kuchroo VK,Ng K,Giannakis M,Nieman LT,Boland GM,Aguirre AJ,Anderson AC,Rozenblatt-Rosen O,Regev A,Hacohen N

Thu Sep 02 00:00:00 EDT 2021

The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.

Nature neuroscience

Wenzel J,Lampe J,Müller-Fielitz H,Schuster R,Zille M,Müller K,Krohn M,Körbelin J,Zhang L,Özorhan Ü,Neve V,Wagner JUG,Bojkova D,Shumliakivska M,Jiang Y,Fähnrich A,Ott F,Sencio V,Robil C,Pfefferle S,Sauve F,Coêlho CFF,Franz J,Spiecker F,Lembrich B,Binder S,Feller N,König P,Busch H,Collin L,Villaseñor R,Jöhren O,Altmeppen HC,Pasparakis M,Dimmeler S,Cinatl J,Püschel K,Zelic M,Ofengeim D,Stadelmann C,Trottein F,Nogueiras R,Hilgenfeld R,Glatzel M,Prevot V,Schwaninger M

Mon Nov 01 00:00:00 EDT 2021

The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.

Nature neuroscience

Mon Nov 01 00:00:00 EDT 2021

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets.

Cell stem cell

Wang T,Pine AR,Kotini AG,Yuan H,Zamparo L,Starczynowski DT,Leslie C,Papapetrou EP

200-01B was used in Sample Preparation (PCR) to identify cell-autonomous dysregulation of inflammatory signaling as an early and persistent event in leukemogenesis and a promising early therapeutic target.

Thu Jun 03 00:00:00 EDT 2021

Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.

Arthritis & rheumatology (Hoboken, N.J.)

Vecellio M,Chen L,Cohen CJ,Cortes A,Li Y,Bonham S,Selmi C,Brown MA,Fischer R,Knight JC,Wordsworth BP

Tue Jun 01 00:00:00 EDT 2021

The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion.

Proceedings of the National Academy of Sciences of the United States of America

Liu J,Jang JY,Pirooznia M,Liu S,Finkel T

Tue Jan 19 00:00:00 EST 2021

Identification of human immune cell subtypes most responsive to IL-1β-induced inflammatory signaling using mass cytometry.

Science signaling

Kothari H,Williams CM,McSkimming C,Drago F,Marshall MA,Garmey J,Vigneshwar M,Zunder ER,McNamara CA

Tue Mar 09 00:00:00 EST 2021

Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes.

Glia

Muraleedharan A,Rotem-Dai N,Strominger I,Anto NP,Isakov N,Monsonego A,Livneh E

Mon Mar 01 00:00:00 EST 2021

Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress.

Brain pathology (Zurich, Switzerland)

Zimmer TS,Korotkov A,Zwakenberg S,Jansen FE,Zwartkruis FJT,Rensing NR,Wong M,Mühlebner A,van Vliet EA,Aronica E,Mills JD

Wed Sep 01 00:00:00 EDT 2021

Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation.

Oxidative medicine and cellular longevity

Ma W,Wang Z,Zhao Y,Wang Q,Zhang Y,Lei P,Lu W,Yan S,Zhou J,Li X,Yu W,Zhong Y,Chen L,Zheng T

Mon Sep 13 00:00:00 EDT 2021

Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity.

Frontiers in cardiovascular medicine

Vreeken D,Bruikman CS,Stam W,Cox SML,Nagy Z,Zhang H,Postma RJ,van Zonneveld AJ,Hovingh GK,van Gils JM

200-01B was used in Cell Culture to conclude that PLXNA4 may well have a causal role in atherogenesis that deserves further investigation.

Sun May 23 00:00:00 EDT 2021

Proinflammatory Features of Stem Cell-like Memory T Cells from Human Patients with Rheumatoid Arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Lee YJ,Park EH,Park JW,Jung KC,Lee EB

Thu Jul 15 00:00:00 EDT 2021

Proteomic Analysis Reveals Commonly Secreted Proteins of Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Synovial Membrane to Show Potential for Cartilage Regeneration in Knee Osteoarthritis.

Stem cells international

Lee Y,Park YS,Choi NY,Kim YI,Koh YG

Tue Jul 27 00:00:00 EDT 2021

Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition.

American journal of physiology. Gastrointestinal and liver physiology

Her JY,Lee Y,Kim SJ,Heo G,Choo J,Kim Y,Howe C,Rhee SH,Yu HS,Chung HY,Pothoulakis C,Im E

Fri Jan 01 00:00:00 EST 2021

Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell.

Mediators of inflammation

Tien PT,Lin CH,Chen CS,Chang CY,Ku H,Gan D,Tsai YY,Chen JJ,Lin HJ,Wan L

Thu Mar 31 00:00:00 EDT 2022

Baicalin promotes chondrocyte viability and the synthesis of extracellular matrix through TGF-β/Smad3 pathway in chondrocytes.

American journal of translational research

Wang P,Liu J,Zhang S,Zhu P,Xiong X,Yu C,Li A,Liu Z

200-01B was used in Cell Culture to study how Baicalin (BA) neutralizes IL-1β-induced downregulation of chondrocyte viability and extracellular matrix (ECM) secretion, including Aggrecan (ACAN) and type II collagen (Col2α).

Sat Oct 16 00:00:00 EDT 2021

Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.

Transfusion

Cunningham S,Hackstein H

Tue Jun 01 00:00:00 EDT 2021

Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells.

Cell adhesion & migration

Roncato F,Regev O,Yadav SK,Alon R

200-01B was used in In vitro experiments on Human derman blood endothelial cells.

Wed Dec 01 00:00:00 EST 2021

Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF-κB and PI3K/AKT Pathways.

Evidence-based complementary and alternative medicine : eCAM

Chen GY,Chen JQ,Liu XY,Xu Y,Luo J,Wang YF,Zhou TL,Yan ZR,Zhou L,Tao QW

Tue May 18 00:00:00 EDT 2021

Shen Shuai II Recipe Attenuates Renal Interstitial Fibrosis by Improving Hypoxia via the IL-1β/c-Myc Pathway.

Evidence-based complementary and alternative medicine : eCAM

Yang L,Wang M,Zhou Y,Yang J,Ye C,Wang C

Sun Apr 24 00:00:00 EDT 2022

ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.

Cell reports

Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J

Tue Aug 24 00:00:00 EDT 2021

Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response.

Communications biology

Enchéry F,Dumont C,Iampietro M,Pelissier R,Aurine N,Bloyet LM,Carbonnelle C,Mathieu C,Journo C,Gerlier D,Horvat B

Tue Nov 16 00:00:00 EST 2021

Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3.

Cell reports

Sun Y,Zhou Y,Shi Y,Zhang Y,Liu K,Liang R,Sun P,Chang X,Tang W,Zhang Y,Li J,Wang S,Zhu Y,Han X

Tue Jan 05 00:00:00 EST 2021

Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration.

eLife

Arts JJ,Mahlandt EK,Grönloh ML,Schimmel L,Noordstra I,Gordon E,van Steen AC,Tol S,Walzog B,van Rijssel J,Nolte MA,Postma M,Khuon S,Heddleston JM,Wait E,Chew TL,Winter M,Montanez E,Goedhart J,van Buul JD

200-01B was used in In vitro experiments to discover a new mechanism that uses local induced junctional membrane protrusions to facilitate/steer the leukocyte escape/exit from inflamed vessel walls.

Wed Aug 25 00:00:00 EDT 2021

Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis.

Cancers

Masselli E,Carubbi C,Pozzi G,Percesepe A,Campanelli R,Villani L,Gobbi G,Bonomini S,Roti G,Rosti V,Massa M,Barosi G,Vitale M

200-01B was used in In vitro experiments to conclude that the identification of the role of the CCL2/CCR2 chemokine system in PMF adds a novel element to the pathophysiological picture of the disease, with clinical and therapeutic implications.

Sat May 22 00:00:00 EDT 2021

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction.

Nature communications

Tombor LS,John D,Glaser SF,Luxán G,Forte E,Furtado M,Rosenthal N,Baumgarten N,Schulz MH,Wittig J,Rogg EM,Manavski Y,Fischer A,Muhly-Reinholz M,Klee K,Looso M,Selignow C,Acker T,Bibli SI,Fleming I,Patrick R,Harvey RP,Abplanalp WT,Dimmeler S

Fri Jan 29 00:00:00 EST 2021

MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascade.

Scientific reports

Tanimura A,Nakazato A,Tanaka N

Wed Feb 17 00:00:00 EST 2021

Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics.

Nature communications

Wilhelm M,Zolg DP,Graber M,Gessulat S,Schmidt T,Schnatbaum K,Schwencke-Westphal C,Seifert P,de Andrade Krätzig N,Zerweck J,Knaute T,Bräunlein E,Samaras P,Lautenbacher L,Klaeger S,Wenschuh H,Rad R,Delanghe B,Huhmer A,Carr SA,Clauser KR,Krackhardt AM,Reimer U,Kuster B

Mon Jun 07 00:00:00 EDT 2021

Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells.

Stem cell reports

Schäfer R,Spohn G,Bechtel M,Bojkova D,Baer PC,Kuçi S,Seifried E,Ciesek S,Cinatl J

Tue Mar 09 00:00:00 EST 2021

Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya.

PLoS neglected tropical diseases

Bedoui Y,Septembre-Malaterre A,Giry C,Jaffar-Bandjee MC,Selambarom J,Guiraud P,Gasque P

200-01B was used in Cell Culture to report novel histological and in vitro data arguing for a plausible role of a COX-2-mediated inflammatory response post-chikungunya virus (CHIKV).

Mon Feb 01 00:00:00 EST 2021

Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.

ImmunoHorizons

Malireddi RKS,Karki R,Sundaram B,Kancharana B,Lee S,Samir P,Kanneganti TD

200-01B was used in Cell Culture to investigate correlations between cytokine expression and mortality.

Wed Jul 21 00:00:00 EDT 2021

Arthritis flares mediated by tissue-resident memory T cells in the joint.

Cell reports

Chang MH,Levescot A,Nelson-Maney N,Blaustein RB,Winden KD,Morris A,Wactor A,Balu S,Grieshaber-Bouyer R,Wei K,Henderson LA,Iwakura Y,Clark RA,Rao DA,Fuhlbrigge RC,Nigrovic PA

Tue Oct 26 00:00:00 EDT 2021

Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release.

Cell death & disease

Egea V,Kessenbrock K,Lawson D,Bartelt A,Weber C,Ries C

Thu May 20 00:00:00 EDT 2021

Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.

Cell death & disease

Zhang W,Yin G,Zhao H,Ling H,Xie Z,Xiao C,Chen Y,Lin Y,Jiang T,Jin S,Wang J,Yang X

Wed Jan 20 00:00:00 EST 2021

Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis.

Cell death & disease

Hou M,Zhang Y,Zhou X,Liu T,Yang H,Chen X,He F,Zhu X

Thu May 13 00:00:00 EDT 2021

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.

Cells

Morein D,Rubinstein-Achiasaf L,Brayer H,Dorot O,Pichinuk E,Ben-Yaakov H,Meshel T,Pasmanik-Chor M,Ben-Baruch A

200-01B was used in Cell Culture to demonstrate that a continuous stimulation (~6 weeks) of triple-negative breast tumor cells (TNBC) by the proinflammatory cytokines tumor necrosis factor α (TNFα) + interleukin 1β (IL-1β) changed the expression of hundreds of genes, skewing the cells towards a proinflammatory phenotype which promotes a prometastatic cascade.

Mon May 31 00:00:00 EDT 2021

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.

Nature communications

Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q

Wed Jul 21 00:00:00 EDT 2021

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.

Nature communications

Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q

Wed Jul 21 00:00:00 EDT 2021

Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis.

Scientific reports

Noda K,Dufner B,Ito H,Yoshida K,Balboni G,Straub RH

Wed Sep 15 00:00:00 EDT 2021

Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells.

Scientific reports

Calandria JM,Bhattacharjee S,Maness NJ,Kautzmann MI,Asatryan A,Gordon WC,Do KV,Jun B,Mukherjee PK,Petasis NA,Bazan NG

Thu Jun 10 00:00:00 EDT 2021

Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.

Nature communications

Fisher AL,Sangkhae V,Balušíková K,Palaskas NJ,Ganz T,Nemeth E

Tue Jun 29 00:00:00 EDT 2021

JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules.

iScience

Jankowski J,Lee HK,Wilflingseder J,Hennighausen L

Fri Aug 20 00:00:00 EDT 2021

Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.

Cell reports

Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T

Tue Jun 08 00:00:00 EDT 2021

Senescence-associated hyper-activation to inflammatory stimuli in vitro.

Aging

Budamagunta V,Manohar-Sindhu S,Yang Y,He Y,Traktuev DO,Foster TC,Zhou D

200-01B was used in Cell Culture to suggest that SnCs may play an important role in the age-related increases in the susceptibility to developing an exacerbated inflammatory response and highlight the potential to use senotherapeutics to ameliorate the severity of various devastating inflammatory conditions in the elderly.

Tue Aug 10 00:00:00 EDT 2021

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.

Cell

Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X

Thu Apr 16 00:00:00 EDT 2020

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.

Cell

Blanco-Melo D,Nilsson-Payant BE,Liu WC,Uhl S,Hoagland D,Møller R,Jordan TX,Oishi K,Panis M,Sachs D,Wang TT,Schwartz RE,Lim JK,Albrecht RA,tenOever BR

Thu May 28 00:00:00 EDT 2020

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses.

Immunity

Zhou R,To KK,Wong YC,Liu L,Zhou B,Li X,Huang H,Mo Y,Luk TY,Lau TT,Yeung P,Chan WM,Wu AK,Lung KC,Tsang OT,Leung WS,Hung IF,Yuen KY,Chen Z

200-01B was used in Sample Preparation (FC/FACS) to investigates effects of SARS-Cov-2 on early immune responses in infection.

Tue Oct 13 00:00:00 EDT 2020

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses.

Immunity

Zhou R,To KK,Wong YC,Liu L,Zhou B,Li X,Huang H,Mo Y,Luk TY,Lau TT,Yeung P,Chan WM,Wu AK,Lung KC,Tsang OT,Leung WS,Hung IF,Yuen KY,Chen Z

200-01B was used in Sample Preparation (FC/FACS) to investigates effects of SARS-Cov-2 on early immune responses in infection.

Tue Oct 13 00:00:00 EDT 2020

GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.

The Journal of clinical investigation

Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y

Thu Oct 01 00:00:00 EDT 2020

GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.

The Journal of clinical investigation

Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y

Thu Oct 01 00:00:00 EDT 2020

C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation.

The Journal of clinical investigation

N'diaye M,Brauner S,Flytzani S,Kular L,Warnecke A,Adzemovic MZ,Piket E,Min JH,Edwards W,Mela F,Choi HY,Magg V,James T,Linden M,Reichardt HM,Daws MR,van Horssen J,Kockum I,Harris RA,Olsson T,Guerreiro-Cacais AO,Jagodic M

Mon Feb 03 00:00:00 EST 2020

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.

Proceedings of the National Academy of Sciences of the United States of America

Cribbs AP,Terlecki-Zaniewicz S,Philpott M,Baardman J,Ahern D,Lindow M,Obad S,Oerum H,Sampey B,Mander PK,Penn H,Wordsworth P,Bowness P,de Winther M,Prinjha RK,Feldmann M,Oppermann U

Tue Mar 17 00:00:00 EDT 2020

microRNA-132 is overexpressed in glia in temporal lobe epilepsy and reduces the expression of pro-epileptogenic factors in human cultured astrocytes.

Glia

Korotkov A,Broekaart DWM,Banchaewa L,Pustjens B,van Scheppingen J,Anink JJ,Baayen JC,Idema S,Gorter JA,van Vliet EA,Aronica E

Wed Jan 01 00:00:00 EST 2020

Presence, function, and regulation of IL-17F-expressing human CD4⁺ T cells.

European journal of immunology

Burns LA,Maroof A,Marshall D,Steel KJA,Lalnunhlimi S,Cole S,Catrina A,Kirkham B,Taams LS

Wed Apr 01 00:00:00 EDT 2020

Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Troullinaki M,Chen LS,Witt A,Pyrina I,Phieler J,Kourtzelis I,Chmelar J,Sprott D,Gercken B,Koutsilieris M,Chavakis T,Chatzigeorgiou A

Sat Feb 01 00:00:00 EST 2020

Pharmacological activation of ERβ by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Tao Y,Yue M,Lv C,Yun X,Qiao S,Fang Y,Wei Z,Xia Y,Dai Y

Sat Feb 01 00:00:00 EST 2020

Inflammatory-sensitive CHI3L1 protects nucleus pulposus via AKT3 signaling during intervertebral disc degeneration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wang R,Xu C,Zhong H,Hu B,Wei L,Liu N,Zhang Y,Shi Q,Wang C,Qi M,Gu Y,Shen X,Tian Y,Liu Y,Cao P,Chen H,Yuan W

Sun Mar 01 00:00:00 EST 2020

Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wei L,Cao P,Xu C,Zhong H,Wang X,Bai M,Hu B,Wang R,Liu N,Tian Y,Chen H,Li J,Yuan W

Tue Dec 01 00:00:00 EST 2020

The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix.

Journal of immunology (Baltimore, Md. : 1950)

Taylor S,Whitfield M,Barratt J,Didangelos A

Thu Oct 15 00:00:00 EDT 2020

Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1β.

Journal of cellular and molecular medicine

Hsueh YJ,Meir YJ,Lai JY,Chen HC,Ma DH,Huang CC,Lu TT,Cheng CM,Wu WC

Mon Jun 01 00:00:00 EDT 2020

Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1β.

Journal of cellular and molecular medicine

Hsueh YJ,Meir YJ,Lai JY,Chen HC,Ma DH,Huang CC,Lu TT,Cheng CM,Wu WC

Mon Jun 01 00:00:00 EDT 2020

Interleukin-1β augments the angiogenesis of endothelial progenitor cells in an NF-κB/CXCR7-dependent manner.

Journal of cellular and molecular medicine

Fan X,He L,Dai Q,He J,Chen X,Dai X,Zhang C,Sun D,Meng X,Sun S,Huang J,Chen J,Lin L,Chen L,Tan Y,Yan X

Fri May 01 00:00:00 EDT 2020

A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury.

Journal of cellular and molecular medicine

Bachmann M,Lamprecht L,Gonther S,Pfeilschifter J,Mühl H

Tue Sep 01 00:00:00 EDT 2020

Chondroprotective and anti-inflammatory effects of amurensin H by regulating TLR4/Syk/NF-κB signals.

Journal of cellular and molecular medicine

Ma P,Yue L,Yang H,Fan Y,Bai J,Li S,Yuan J,Zhang Z,Yao C,Lin M,Hou Q

Wed Jan 01 00:00:00 EST 2020

Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.

Journal of cellular and molecular medicine

Wang X,Chen Z,Fan X,Li W,Qu J,Dong C,Wang Z,Ji Z,Li Y

Wed Jan 01 00:00:00 EST 2020

Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.

Journal of cell science

Mc Fie M,Koneva L,Collins I,Coveney CR,Clube AM,Chanalaris A,Vincent TL,Bezbradica JS,Sansom SN,Wann AKT

200-01B was used in Cell Culture to study how IFT88 depletion affects specific cytokine-regulated behaviours, changing cytosolic NFκB translocation dynamics but leaving MAPK signalling unaffected.

Wed Jul 08 00:00:00 EDT 2020

Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome.

International immunology

Niitsuma S,Kudo H,Kikuchi A,Hayashi T,Kumakura S,Kobayashi S,Okuyama Y,Kumagai N,Niihori T,Aoki Y,So T,Funayama R,Nakayama K,Shirota M,Kondo S,Kagami S,Tsukaguchi H,Iijima K,Kure S,Ishii N

200-01B was used in Cell Culture to investigate causative genes in steroid-sensitive nephrotic syndrome.

Sun Apr 12 00:00:00 EDT 2020

Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing.

Scientific reports

Shin JU,Abaci HE,Herron L,Guo Z,Sallee B,Pappalardo A,Jackow J,Wang EHC,Doucet Y,Christiano AM

Thu Mar 05 00:00:00 EST 2020

Visfatin/eNampt induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and NLRP3 inflammasome.

Scientific reports

Romacho T,Valencia I,Ramos-González M,Vallejo S,López-Esteban M,Lorenzo O,Cannata P,Romero A,San Hipólito-Luengo A,Gómez-Cerezo JF,Peiró C,Sánchez-Ferrer CF

Wed Mar 25 00:00:00 EDT 2020

A circular RNA generated from an intron of the insulin gene controls insulin secretion.

Nature communications

Stoll L,Rodríguez-Trejo A,Guay C,Brozzi F,Bayazit MB,Gattesco S,Menoud V,Sobel J,Marques AC,Venø MT,Esguerra JLS,Barghouth M,Suleiman M,Marselli L,Kjems J,Eliasson L,Renström E,Bouzakri K,Pinget M,Marchetti P,Regazzi R

Thu Nov 05 00:00:00 EST 2020

A circular RNA generated from an intron of the insulin gene controls insulin secretion.

Nature communications

Thu Nov 05 00:00:00 EST 2020

Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate-Novel Insights.

Cancers

Povo-Retana A,Mojena M,Stremtan AB,Fernández-García VB,Gómez-Sáez A,Nuevo-Tapioles C,Molina-Guijarro JM,Avendaño-Ortiz J,Cuezva JM,López-Collazo E,Martínez-Leal JF,Boscá L

200-01B was used in In vitro experiments to study the effect of trabectedin and lurbinectedin on human macrophage cell viability and function.

Tue Oct 20 00:00:00 EDT 2020

Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis.

PloS one

Baeza-Raja B,Goodyear A,Liu X,Lam K,Yamamoto L,Li Y,Dodson GS,Takeuchi T,Kisseleva T,Brenner DA,Dabbagh K

200-01B was used in Cell Culture to report that P2RX7 is expressed by infiltrating monocytes and resident Kupffer cells in livers from NASH-affected individuals.

Fri Aug 21 00:00:00 EDT 2020

Inhibition of mitochondrial oxidative metabolism attenuates EMCV replication and protects β-cells from virally mediated lysis.

The Journal of biological chemistry

Stafford JD,Shaheen ZR,Yeo CT,Corbett JA

Fri Dec 04 00:00:00 EST 2020

The location of sensing determines the pancreatic β-cell response to the viral mimetic dsRNA.

The Journal of biological chemistry

Shaheen ZR,Stafford JD,Voss MG,Oleson BJ,Stancill JS,Corbett JA

Fri Feb 21 00:00:00 EST 2020

SIRT1 directly activates autophagy in human chondrocytes.

Cell death discovery

Sacitharan PK,Bou-Gharios G,Edwards JR

Tue Sep 26 00:00:00 EDT 2023

κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis.

Nature communications

Beel S,Kolloch L,Apken LH,Jürgens L,Bolle A,Sudhof N,Ghosh S,Wardelmann E,Meisterernst M,Steinestel K,Oeckinghaus A

Wed Jul 08 00:00:00 EDT 2020

Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.

Nature communications

Evans RDR,Antonelou M,Sathiananthamoorthy S,Rega M,Henderson S,Ceron-Gutierrez L,Barcenas-Morales G,Müller CA,Doffinger R,Walsh SB,Salama AD

Mon Aug 31 00:00:00 EDT 2020

Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer.

Cells

Mandelli GE,Missale F,Bresciani D,Gatta LB,Scapini P,Caveggion E,Roca E,Bugatti M,Monti M,Cristinelli L,Belotti S,Simeone C,Calza S,Melocchi L,Vermi W

200-01B was used in In vitro experiments to explore the density and clinical significance of CD66b+ tumor-associated-neutrophils (TAN) and CD3+ T cells.

Sat Jan 25 00:00:00 EST 2020

β2-adrenergic stimulation induces interleukin-6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts.

Pharmacology research & perspectives

Tanaka S,Imaeda A,Matsumoto K,Maeda M,Obana M,Fujio Y

Wed Apr 01 00:00:00 EDT 2020

β2-adrenergic stimulation induces interleukin-6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts.

Pharmacology research & perspectives

Tanaka S,Imaeda A,Matsumoto K,Maeda M,Obana M,Fujio Y

Wed Apr 01 00:00:00 EDT 2020

Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis.

Cell death discovery

Tsuji G,Hashimoto-Hachiya A,Yen VH,Takemura M,Yumine A,Furue K,Furue M,Nakahara T

Tue Sep 26 00:00:00 EDT 2023

TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells.

Cells

Cambria E,Arlt MJE,Wandel S,Krupkova O,Hitzl W,Passini FS,Hausmann ON,Snedeker JG,Ferguson SJ,Wuertz-Kozak K

200-01B was used in In vitro experiments to investigate potential pharmacological targets to treat degenerative disc disease and low back pain.

Tue Jul 21 00:00:00 EDT 2020

T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation.

Cell reports

Yan J,Pandey SP,Barnes BJ,Turner JR,Abraham C

200-01B was used in In vitro experiments to identify a previously undefined key role for T cell-intrinsic IRF5. In mice, IRF5 in CD4+ T cells promotes Th1- and Th17-associated cytokines and decreases Th2-associated cytokines.

Tue Jun 30 00:00:00 EDT 2020

Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity.

Scientific reports

Sousa C,Leitão AJ,Neves BM,Judas F,Cavaleiro C,Mendes AF

Wed Apr 29 00:00:00 EDT 2020

Metabolic alterations in Parkinson's disease astrocytes.

Scientific reports

Sonninen TM,Hämäläinen RH,Koskuvi M,Oksanen M,Shakirzyanova A,Wojciechowski S,Puttonen K,Naumenko N,Goldsteins G,Laham-Karam N,Lehtonen M,Tavi P,Koistinaho J,Lehtonen Š

Wed Sep 02 00:00:00 EDT 2020

Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis.

Scientific reports

Ingvarsen SZ,Gårdsvoll H,van Putten S,Nørregaard KS,Krigslund O,Meilstrup JA,Tran C,Jürgensen HJ,Melander MC,Nielsen CH,Kjaer A,Bugge TH,Engelholm LH,Behrendt N

Thu Nov 05 00:00:00 EST 2020

Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53.

The Journal of biological chemistry

Zhang J,Xu M,Zhou W,Li D,Zhang H,Chen Y,Ning L,Zhang Y,Li S,Yu M,Chen Y,Zeng H,Cen L,Zhou T,Zhou X,Lu C,Yu C,Li Y,Sun J,Kong X,Shen Z

Fri Mar 27 00:00:00 EDT 2020

Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53.

The Journal of biological chemistry

Zhang J,Xu M,Zhou W,Li D,Zhang H,Chen Y,Ning L,Zhang Y,Li S,Yu M,Chen Y,Zeng H,Cen L,Zhou T,Zhou X,Lu C,Yu C,Li Y,Sun J,Kong X,Shen Z

Fri Mar 27 00:00:00 EDT 2020

IL-17F induces inflammation, dysfunction and cell death in mouse islets.

Scientific reports

Catterall T,Fynch S,Kay TWH,Thomas HE,Sutherland APR

Tue Aug 04 00:00:00 EDT 2020

A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication.

Cell

Grandclaudon M,Perrot-Dockès M,Trichot C,Karpf L,Abouzid O,Chauvin C,Sirven P,Abou-Jaoudé W,Berger F,Hupé P,Thieffry D,Sansonnet L,Chiquet J,Lévy-Leduc C,Soumelis V

200-01B was used in Sample Prep to describe an integrative approach involving protein-level measurement of multiple communication signals coupled to output responses in receiving cells and mathematical modeling to uncover input-output relationships and interactions between signals.

Thu Oct 03 00:00:00 EDT 2019

A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication.

Cell

Grandclaudon M,Perrot-Dockès M,Trichot C,Karpf L,Abouzid O,Chauvin C,Sirven P,Abou-Jaoudé W,Berger F,Hupé P,Thieffry D,Sansonnet L,Chiquet J,Lévy-Leduc C,Soumelis V

Thu Oct 03 00:00:00 EDT 2019

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.

Immunity

Schwartz DM,Farley TK,Richoz N,Yao C,Shih HY,Petermann F,Zhang Y,Sun HW,Hayes E,Mikami Y,Jiang K,Davis FP,Kanno Y,Milner JD,Siegel R,Laurence A,Meylan F,O'Shea JJ

Tue Jan 15 00:00:00 EST 2019

Germline mutations in the transcription factor IKZF5 cause thrombocytopenia.

Blood

Lentaigne C,Greene D,Sivapalaratnam S,Favier R,Seyres D,Thys C,Grassi L,Mangles S,Sibson K,Stubbs M,Burden F,Bordet JC,Armari-Alla C,Erber W,Farrow S,Gleadall N,Gomez K,Megy K,Papadia S,Penkett CJ,Sims MC,Stefanucci L,Stephens JC,Read RJ,Stirrups KE,Ouwehand WH,Laffan MA,Frontini M,Freson K,Turro E

Thu Dec 05 00:00:00 EST 2019

Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.

The Journal of experimental medicine

Spencer S,Köstel Bal S,Egner W,Lango Allen H,Raza SI,Ma CA,Gürel M,Zhang Y,Sun G,Sabroe RA,Greene D,Rae W,Shahin T,Kania K,Ardy RC,Thian M,Staples E,Pecchia-Bekkum A,Worrall WPM,Stephens J,Brown M,Tuna S,York M,Shackley F,Kerrin D,Sargur R,Condliffe A,Tipu HN,Kuehn HS,Rosenzweig SD,Turro E,Tavaré S,Thrasher AJ,Jodrell DI,Smith KGC,Boztug K,Milner JD,Thaventhiran JED

Mon Sep 02 00:00:00 EDT 2019

An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.

Cancer research

Carter BZ,Mak PY,Wang X,Tao W,Ruvolo V,Mak D,Mu H,Burks JK,Andreeff M

200-01B was used in Cell Culture to conclude that the antiapoptotic protein ARC promotes AML aggressiveness by enabling detrimental cross-talk with bone marrow mesenchymal stromal cells.

Fri Mar 15 00:00:00 EDT 2019

Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.

Proceedings of the National Academy of Sciences of the United States of America

Lu Y,Stuart JH,Talbot-Cooper C,Agrawal-Singh S,Huntly B,Smid AI,Snowden JS,Dupont L,Smith GL

Tue Jun 11 00:00:00 EDT 2019

NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation.

Proceedings of the National Academy of Sciences of the United States of America

Neidel S,Ren H,Torres AA,Smith GL

Tue Mar 19 00:00:00 EDT 2019

Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset.

Aging cell

Martini H,Iacovoni JS,Maggiorani D,Dutaur M,Marsal DJ,Roncalli J,Itier R,Dambrin C,Pizzinat N,Mialet-Perez J,Cussac D,Parini A,Lefevre L,Douin-Echinard V

Tue Oct 01 00:00:00 EDT 2019

The angiotensin-(1-7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation.

Aging cell

Romero A,San Hipólito-Luengo Á,Villalobos LA,Vallejo S,Valencia I,Michalska P,Pajuelo-Lozano N,Sánchez-Pérez I,León R,Bartha JL,Sanz MJ,Erusalimsky JD,Sánchez-Ferrer CF,Romacho T,Peiró C

Sat Jun 01 00:00:00 EDT 2019

Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.

British journal of cancer

Chen Q,Wang J,Zhang Q,Zhang J,Lou Y,Yang J,Chen Y,Wei T,Zhang J,Fu Q,Ye M,Zhang X,Dang X,Liang T,Bai X

Tue Oct 01 00:00:00 EDT 2019

CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation.

Osteoarthritis and cartilage

Seidl CI,Fulga TA,Murphy CL

200-01B was used in In vitro experiments to investigate CRISPR editing of chondrocytes.

Tue Jan 01 00:00:00 EST 2019

RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme.

Oncogenesis

Waters MR,Gupta AS,Mockenhaupt K,Brown LN,Biswas DD,Kordula T

Wed May 29 00:00:00 EDT 2019

USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.

Journal of immunology (Baltimore, Md. : 1950)

Lei CQ,Wu X,Zhong X,Jiang L,Zhong B,Shu HB

200-01B was used in In vitro experiments to investigate ubiquitination of TAK1.

Mon Jul 01 00:00:00 EDT 2019

Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts.

Journal of periodontal research

Janjić K,Schellner A,Engenhart A,Kernstock K,Schädl B,Moritz A,Agis H

Tue Oct 01 00:00:00 EDT 2019

Activity of two hyaluronan preparations on primary human oral fibroblasts.

Journal of periodontal research

Asparuhova MB,Kiryak D,Eliezer M,Mihov D,Sculean A

Fri Feb 01 00:00:00 EST 2019

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8⁺ T cell inhibition.

Nature communications

Pereira BI,Devine OP,Vukmanovic-Stejic M,Chambers ES,Subramanian P,Patel N,Virasami A,Sebire NJ,Kinsler V,Valdovinos A,LeSaux CJ,Passos JF,Antoniou A,Rustin MHA,Campisi J,Akbar AN

Mon Jun 03 00:00:00 EDT 2019

Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-α-stimulated gene-6 in inflammatory bowel disease models.

Cell death & disease

Yang H,Feng R,Fu Q,Xu S,Hao X,Qiu Y,Feng T,Zeng Z,Chen M,Zhang S

Thu Sep 26 00:00:00 EDT 2019

Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells.

Scientific reports

Shokri MR,Bozorgmehr M,Ghanavatinejad A,Falak R,Aleahmad M,Kazemnejad S,Shokri F,Zarnani AH

Wed Jul 10 00:00:00 EDT 2019

The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis.

Scientific reports

Dimou P,Wright RD,Budge KL,Midgley A,Satchell SC,Peak M,Beresford MW

Thu Jun 06 00:00:00 EDT 2019

A network-centric approach to drugging TNF-induced NF-κB signaling.

Nature communications

Pabon NA,Zhang Q,Cruz JA,Schipper DL,Camacho CJ,Lee REC

Tue Feb 26 00:00:00 EST 2019

A novel mechanism for the protection of embryonic stem cell derived tenocytes from inflammatory cytokine interleukin 1 beta.

Scientific reports

McClellan A,Evans R,Sze C,Kan S,Paterson Y,Guest D

Tue Feb 26 00:00:00 EST 2019

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology.

Cell death & disease

Derada Troletti C,Fontijn RD,Gowing E,Charabati M,van Het Hof B,Didouh I,van der Pol SMA,Geerts D,Prat A,van Horssen J,Kooij G,de Vries HE

Fri Jan 18 00:00:00 EST 2019

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer.

Frontiers in immunology

Liubomirski Y,Lerrer S,Meshel T,Rubinstein-Achiasaf L,Morein D,Wiemann S,Körner C,Ben-Baruch A

200-01B was used in Sample Preparation (ELISA) to study the impact of tumor-stroma-inflammation networks on pro-metastatic phenotypes in triple-negative breast cancer (TNBC) to identify a novel tumor-stroma-inflammation networks that may promote TNBC aggressiveness by increasing the pro-malignancy potential of the TME and of the tumor cells themselves, and reveal key roles for CXCL8 in mediating these metastasis-promoting activities.

Mon Aug 10 00:00:00 EDT 2020

NOD1 modulates decidual stromal cell function to maintain pregnancy in the early trimester.

Cell biochemistry and function

Zhang Y,Zhang Y,Li C,Fu S,Yang C,Song Y,Liu M,Wang Z,Liang P,Zhang J

200-01B was used in Cell Culture to indicate that RPL may be associated with NOD1 aberrant expression in DSCs, which plays a significant role in maintaining pregnancy via infection control and regulation of immune responses that might affect the pregnancy outcome.

Tue Oct 01 00:00:00 EDT 2019

IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus-infected human macrophages.

The Journal of biological chemistry

Magoro T,Dandekar A,Jennelle LT,Bajaj R,Lipkowitz G,Angelucci AR,Bessong PO,Hahn YS

Fri Oct 04 00:00:00 EDT 2019

HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β.

Oncotarget

Tawara K,Scott H,Emathinger J,Wolf C,LaJoie D,Hedeen D,Bond L,Montgomery P,Jorcyk C

200-01B was used in In vitro experiments to study how interleukin-6 (IL-6), oncostatin M (OSM), and interleukin-1 beta (IL-1β) cytokines are interrelated in expression to suggest a rationale for a breast cancer treatment regime that simultaneously suppresses multiple targets, as these cytokines possess many overlapping functions that increase metastasis and worsen patient survival.

Tue Mar 12 00:00:00 EDT 2019

M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling.

Frontiers in immunology

Zong Z,Zou J,Mao R,Ma C,Li N,Wang J,Wang X,Zhou H,Zhang L,Shi Y

200-01B was used in In vitro experiments to demonstrate that M1 macrophages induced expression of PD-L1 in HCC cells, supporting the pro-tumor role of M1 macrophages.

Wed Oct 14 00:00:00 EDT 2020

The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation.

Cell death & disease

Fu H,Alabdullah M,Großmann J,Spieler F,Abdosh R,Lutz V,Kalies K,Knöpp K,Rieckmann M,Koch S,Noutsias M,Pilowski C,Dutzmann J,Sedding D,Hüttelmaier S,Umezawa K,Werdan K,Loppnow H

Thu Nov 21 00:00:00 EST 2019

Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease.

Scientific reports

Dosh RH,Jordan-Mahy N,Sammon C,Le Maitre CL

Tue Feb 12 00:00:00 EST 2019

Identification of stably expressed housekeeping miRNAs in endothelial cells and macrophages in an inflammatory setting.

Scientific reports

Link F,Krohn K,Schumann J

Wed Sep 04 00:00:00 EDT 2019

LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.

Cell reports

Huang C,Hedl M,Ranjan K,Abraham C

200-01B was used in Cell Culture to investigate that, if, upon stimulation of the pattern-recognition receptor (PRR) NOD2, LACC1 localizes to the endoplasmic reticulum (ER) and forms a complex with ER-stress sensors.

Tue Dec 24 00:00:00 EST 2019

Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages.

PloS one

Jumeau C,Awad F,Assrawi E,Cobret L,Duquesnoy P,Giurgea I,Valeyre D,Grateau G,Amselem S,Bernaudin JF,Karabina SA

200-01B was used in In vitro experiments to investigate serum amyloid A expression by monocytes.

Fri Jan 24 00:00:00 EST 2020

The N-Acetyl Phenylalanine Glucosamine Derivative Attenuates the Inflammatory/Catabolic Environment in a Chondrocyte-Synoviocyte Co-Culture System.

Scientific reports

Pagani S,Minguzzi M,Sicuro L,Veronesi F,Santi S,Scotto D'Abusco A,Fini M,Borzì RM

Thu Sep 19 00:00:00 EDT 2019

Vitamin D Switches BAF Complexes to Protect β Cells.

Cell

Wei Z,Yoshihara E,He N,Hah N,Fan W,Pinto AFM,Huddy T,Wang Y,Ross B,Estepa G,Dai Y,Ding N,Sherman MH,Fang S,Zhao X,Liddle C,Atkins AR,Yu RT,Downes M,Evans RM

Thu May 17 00:00:00 EDT 2018

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Cell

Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E

200-01B was used in In vitro experiments to report here an unexpected finding that macrophages after antibody-dependent cellular cytotoxicity inhibit NK cell-mediated antibody-dependent cellular cytotoxicity and T cell-mediated cytotoxicity in breast cancers and lymphomas.

Thu Oct 04 00:00:00 EDT 2018

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Cell

Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

Thu Jan 25 00:00:00 EST 2018

The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells.

Immunity

Bando JK,Gilfillan S,Song C,McDonald KG,Huang SC,Newberry RD,Kobayashi Y,Allan DSJ,Carlyle JR,Cella M,Colonna M

Tue Jun 19 00:00:00 EDT 2018

Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.

Cell host & microbe

Johnson JS,Lucas SY,Amon LM,Skelton S,Nazitto R,Carbonetti S,Sather DN,Littman DR,Aderem A

200-01B was used in Cell Culture to study how dendritic cells (DCs) detect HIV-1 in distinct phases, before and after virus integration in response to reverse transcription.

Wed Mar 14 00:00:00 EDT 2018

MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.

The Journal of clinical investigation

Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q

Fri Jun 01 00:00:00 EDT 2018

MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.

The Journal of clinical investigation

Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q

Fri Jun 01 00:00:00 EDT 2018

Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.

The Journal of experimental medicine

Li N,van Unen V,Höllt T,Thompson A,van Bergen J,Pezzotti N,Eisemann E,Vilanova A,Chuva de Sousa Lopes SM,Lelieveldt BPF,Koning F

Mon May 07 00:00:00 EDT 2018

Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies.

Clinical cancer research : an official journal of the American Association for Cancer Research

L'Italien L,Orozco O,Abrams T,Cantagallo L,Connor A,Desai J,Ebersbach H,Gelderblom H,Hoffmaster K,Lees E,Maacke H,Schleyer S,Skegro D,Lee-Hoeflich ST

200-01B was used in In vitro experiments to identifying potential mitigation strategies in hypersensitivity reactions.

Sun Jul 15 00:00:00 EDT 2018

Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis.

Experimental & molecular medicine

Choi HJ,Chung TW,Choi HJ,Han JH,Choi JH,Kim CH,Ha KT

Wed Dec 12 00:00:00 EST 2018

Lymphatic exosomes promote dendritic cell migration along guidance cues.

The Journal of cell biology

Brown M,Johnson LA,Leone DA,Majek P,Vaahtomeri K,Senfter D,Bukosza N,Schachner H,Asfour G,Langer B,Hauschild R,Parapatics K,Hong YK,Bennett KL,Kain R,Detmar M,Sixt M,Jackson DG,Kerjaschki D

Mon Jun 04 00:00:00 EDT 2018

Immune Assisted Tissue Engineering via Incorporation of Macrophages in Cell-Laden Hydrogels Under Cytokine Stimulation.

Frontiers in bioengineering and biotechnology

Barthes J,Dollinger C,Muller CB,Liivas U,Dupret-Bories A,Knopf-Marques H,Vrana NE

200-01B was used in Enzyme-linked immunosorbent assay to demonstrate that incorporation of macrophages in a resident macrophage function and their phenotype control have significant effects on the maturation and cytokine microenvironment of 3-D multiple cell type-laden hydrogels, which can be harnessed for better integration of implantable systems and for more physiologically relevant in vitro tissue models with an immune component.

Thu Oct 01 00:00:00 EDT 2020

BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation.

Journal of cellular and molecular medicine

Pardali E,Makowski LM,Leffers M,Borgscheiper A,Waltenberger J

Thu Nov 01 00:00:00 EDT 2018

MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery.

SLAS discovery : advancing life sciences R & D

Young J,Margaron Y,Fernandes M,Duchemin-Pelletier E,Michaud J,Flaender M,Lorintiu O,Degot S,Poydenot P

200-01B was used in In vitro experiments to investigate MyoScreen treatment of muscle atrophy and disease.

Sat Sep 01 00:00:00 EDT 2018

Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue.

Scientific reports

Stebe-Frick S,Ostaff MJ,Stange EF,Malek NP,Wehkamp J

Mon Aug 27 00:00:00 EDT 2018

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration.

Cell death & disease

Chen J,Xie JJ,Jin MY,Gu YT,Wu CC,Guo WJ,Yan YZ,Zhang ZJ,Wang JL,Zhang XL,Lin Y,Sun JL,Zhu GH,Wang XY,Wu YS

Fri Jan 19 00:00:00 EST 2018

Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: a pivotal interplay in the pathogenesis of Atopic Dermatitis.

Scientific reports

Di Domenico EG,Cavallo I,Bordignon V,Prignano G,Sperduti I,Gurtner A,Trento E,Toma L,Pimpinelli F,Capitanio B,Ensoli F

Thu Jun 28 00:00:00 EDT 2018

GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis.

Cell death & disease

Jia W,Wu W,Yang D,Xiao C,Huang M,Long F,Su Z,Qin M,Liu X,Zhu YZ

Tue May 01 00:00:00 EDT 2018

IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.

Nature communications

Zhao M,Tan Y,Peng Q,Huang C,Guo Y,Liang G,Zhu B,Huang Y,Liu A,Wang Z,Li M,Gao X,Wu R,Wu H,Long H,Lu Q

Thu Feb 08 00:00:00 EST 2018

IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.

Scientific reports

Ahsan F,Maertzdorf J,Guhlich-Bornhof U,Kaufmann SHE,Moura-Alves P

Wed Jan 24 00:00:00 EST 2018

IL-1β- and IL-4-polarized macrophages have opposite effects on adipogenesis of intramuscular fibro-adipogenic progenitors in humans.

Scientific reports

Moratal C,Raffort J,Arrighi N,Rekima S,Schaub S,Dechesne CA,Chinetti G,Dani C

Mon Nov 19 00:00:00 EST 2018

A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects.

Nature communications

Petersen A,Princ A,Korus G,Ellinghaus A,Leemhuis H,Herrera A,Klaumünzer A,Schreivogel S,Woloszyk A,Schmidt-Bleek K,Geissler S,Heschel I,Duda GN

Thu Oct 25 00:00:00 EDT 2018

Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny.

Scientific reports

Beaudry-Richard A,Nadeau-Vallée M,Prairie É,Maurice N,Heckel É,Nezhady M,Pundir S,Madaan A,Boudreault A,Hou X,Quiniou C,Sierra EM,Beaulac A,Lodygensky G,Robertson SA,Keelan J,Adams Waldorf KM,Olson DM,Rivera JC,Lubell WD,Joyal JS,Bouchard JF,Chemtob S

Wed Aug 08 00:00:00 EDT 2018

Regulation of IL-22BP in psoriasis.

Scientific reports

Voglis S,Moos S,Kloos L,Wanke F,Zayoud M,Pelczar P,Giannou AD,Pezer S,Albers M,Luessi F,Huber S,Schäkel K,Kurschus FC

Fri Mar 23 00:00:00 EDT 2018

A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics.

Journal of immunology (Baltimore, Md. : 1950)

Han K,Nguyen A,Traba J,Yao X,Kaler M,Huffstutler RD,Levine SJ,Sack MN

Sat Sep 01 00:00:00 EDT 2018

Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells.

Scientific reports

Martin-Gallausiaux C,Béguet-Crespel F,Marinelli L,Jamet A,Ledue F,Blottière HM,Lapaque N

Wed Jun 27 00:00:00 EDT 2018

Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses.

PLoS neglected tropical diseases

Bedoui Y,Giry C,Jaffar-Bandjee MC,Selambarom J,Guiraud P,Gasque P

200-01B was used in In vitro experiments to argue for a beneficial effect of MTX to treat CIR post-CHIKV given that it does not critically impact the antiviral, the proinflammatory and the bone tissue remodeling responses of synovial cells.

Wed Aug 01 00:00:00 EDT 2018

PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients.

The Journal of experimental medicine

Zhang Y,Ma CA,Lawrence MG,Break TJ,O'Connell MP,Lyons JJ,López DB,Barber JS,Zhao Y,Barber DL,Freeman AF,Holland SM,Lionakis MS,Milner JD

Mon Sep 04 00:00:00 EDT 2017

TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.

The Journal of experimental medicine

Pattarini L,Trichot C,Bogiatzi S,Grandclaudon M,Meller S,Keuylian Z,Durand M,Volpe E,Madonna S,Cavani A,Chiricozzi A,Romanelli M,Hori T,Hovnanian A,Homey B,Soumelis V

Mon May 01 00:00:00 EDT 2017

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.

The Journal of experimental medicine

Young HL,Rowling EJ,Bugatti M,Giurisato E,Luheshi N,Arozarena I,Acosta JC,Kamarashev J,Frederick DT,Cooper ZA,Reuben A,Gil J,Flaherty KT,Wargo JA,Vermi W,Smith MP,Wellbrock C,Hurlstone A

Mon Jun 05 00:00:00 EDT 2017

A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome.

The Journal of experimental medicine

Pierce RW,Merola J,Lavik JP,Kluger MS,Huttner A,Khokha MK,Pober JS

Mon Dec 04 00:00:00 EST 2017

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β.

The Journal of experimental medicine

Weichand B,Popp R,Dziumbla S,Mora J,Strack E,Elwakeel E,Frank AC,Scholich K,Pierre S,Syed SN,Olesch C,Ringleb J,Ören B,Döring C,Savai R,Jung M,von Knethen A,Levkau B,Fleming I,Weigert A,Brüne B

Mon Sep 04 00:00:00 EDT 2017

TRPM2-mediated rise in mitochondrial Zn²⁺ promotes palmitate-induced mitochondrial fission and pancreatic β-cell death in rodents.

Cell death and differentiation

Li F,Munsey TS,Sivaprasadarao A

Fri Dec 01 00:00:00 EST 2017

Curtailed T-cell activation curbs effector differentiation and generates CD8⁺ T cells with a naturally-occurring memory stem cell phenotype.

European journal of immunology

Zanon V,Pilipow K,Scamardella E,De Paoli F,De Simone G,Price DA,Martinez Usatorre A,Romero P,Mavilio D,Roberto A,Lugli E

Fri Sep 01 00:00:00 EDT 2017

Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction.

Journal of immunology (Baltimore, Md. : 1950)

Brien ME,Duval C,Palacios J,Boufaied I,Hudon-Thibeault AA,Nadeau-Vallée M,Vaillancourt C,Sibley CP,Abrahams VM,Jones RL,Girard S

Sun Jan 01 00:00:00 EST 2017

Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice.

Journal of immunology (Baltimore, Md. : 1950)

Nadeau-Vallée M,Chin PY,Belarbi L,Brien MÈ,Pundir S,Berryer MH,Beaudry-Richard A,Madaan A,Sharkey DJ,Lupien-Meilleur A,Hou X,Quiniou C,Beaulac A,Boufaied I,Boudreault A,Carbonaro A,Doan ND,Joyal JS,Lubell WD,Olson DM,Robertson SA,Girard S,Chemtob S

200-01B was used in Enzyme-linked immunosorbent assay to develop treatment for drugs targeting preterm birth-associated utero foetal inflammation.

Wed Mar 01 00:00:00 EST 2017

Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice.

Journal of immunology (Baltimore, Md. : 1950)

200-01B was used in Enzyme-linked immunosorbent assay to develop treatment for drugs targeting preterm birth-associated utero foetal inflammation.

Wed Mar 01 00:00:00 EST 2017

A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Montoya MM,Maul J,Singh PB,Pua HH,Dahlström F,Wu N,Huang X,Ansel KM,Baumjohann D

Sat Jul 15 00:00:00 EDT 2017

IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB.

Journal of immunology (Baltimore, Md. : 1950)

Victor AR,Nalin AP,Dong W,McClory S,Wei M,Mao C,Kladney RD,Youssef Y,Chan WK,Briercheck EL,Hughes T,Scoville SD,Pitarresi JR,Chen C,Manz S,Wu LC,Zhang J,Ostrowski MC,Freud AG,Leone GW,Caligiuri MA,Yu J

Sun Oct 01 00:00:00 EDT 2017

Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway.

Journal of cellular and molecular medicine

Wang Z,Huang J,Zhou S,Luo F,Xu W,Wang Q,Tan Q,Chen L,Wang J,Chen H,Chen L,Xie Y,Du X

Fri Dec 01 00:00:00 EST 2017

N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.

Bioscience reports

Kehlen A,Haegele M,Böhme L,Cynis H,Hoffmann T,Demuth HU

200-01B was used in In vitro experiments to suggest that QC-catalysed N-terminal pGlu formation of CX3CL1 is important for the stability or the interaction with its receptor and opens new insights into the function of QC in inflammation.

Thu Aug 31 00:00:00 EDT 2017

Induction of antimicrobial peptides secretion by IL-1β enhances human amniotic membrane for regenerative medicine.

Scientific reports

Tehrani FA,Modaresifar K,Azizian S,Niknejad H

Tue Dec 05 00:00:00 EST 2017

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration.

Scientific reports

Wang S,Liu C,Sun Z,Yan P,Liang H,Huang K,Li C,Tian J

Fri Jun 23 00:00:00 EDT 2017

Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment.

Scientific reports

Mills JD,Iyer AM,van Scheppingen J,Bongaarts A,Anink JJ,Janssen B,Zimmer TS,Spliet WG,van Rijen PC,Jansen FE,Feucht M,Hainfellner JA,Krsek P,Zamecnik J,Kotulska K,Jozwiak S,Jansen A,Lagae L,Curatolo P,Kwiatkowski DJ,Pasterkamp RJ,Senthilkumar K,von Oerthel L,Hoekman MF,Gorter JA,Crino PB,Mühlebner A,Scicluna BP,Aronica E

Mon Aug 14 00:00:00 EDT 2017

Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.

The Journal of biological chemistry

Majkowska I,Shitomi Y,Ito N,Gray NS,Itoh Y

Fri Apr 21 00:00:00 EDT 2017

miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment.

Scientific reports

Mayer U,Benditz A,Grässel S

Mon Oct 16 00:00:00 EDT 2017

Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.

Nature communications

Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A

Mon Oct 09 00:00:00 EDT 2017

Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis.

Scientific reports

Gibson AL,Hui Mingalone CK,Foote AT,Uchimura T,Zhang M,Zeng L

Mon Feb 06 00:00:00 EST 2017

Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis.

Scientific reports

Gibson AL,Hui Mingalone CK,Foote AT,Uchimura T,Zhang M,Zeng L

Mon Feb 06 00:00:00 EST 2017

Co-expression of 1α-hydroxylase and vitamin D receptor in human articular chondrocytes.

BMC musculoskeletal disorders

Hansen AK,Figenschau Y,Zubiaurre-Martinez I

200-01B was used in Cell Culture to study whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active hormone 1α,25(OH)2D3, namely 1α-hydroxylase (CYP27B1).

Mon Nov 06 00:00:00 EST 2017

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.

Stem cell reports

Tripathi P,Rodriguez-Muela N,Klim JR,de Boer AS,Agrawal S,Sandoe J,Lopes CS,Ogliari KS,Williams LA,Shear M,Rubin LL,Eggan K,Zhou Q

Tue Aug 08 00:00:00 EDT 2017

Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium.

Scientific reports

Terenzi R,Manetti M,Rosa I,Romano E,Galluccio F,Guiducci S,Ibba-Manneschi L,Matucci-Cerinic M

Mon Oct 16 00:00:00 EDT 2017

Heparanase and macrophage interplay in the onset of liver fibrosis.

Scientific reports

Secchi MF,Crescenzi M,Masola V,Russo FP,Floreani A,Onisto M

Thu Nov 02 00:00:00 EDT 2017

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

The Journal of experimental medicine

Wang Y,Ma CS,Ling Y,Bousfiha A,Camcioglu Y,Jacquot S,Payne K,Crestani E,Roncagalli R,Belkadi A,Kerner G,Lorenzo L,Deswarte C,Chrabieh M,Patin E,Vincent QB,Müller-Fleckenstein I,Fleckenstein B,Ailal F,Quintana-Murci L,Fraitag S,Alyanakian MA,Leruez-Ville M,Picard C,Puel A,Bustamante J,Boisson-Dupuis S,Malissen M,Malissen B,Abel L,Hovnanian A,Notarangelo LD,Jouanguy E,Tangye SG,Béziat V,Casanova JL

Mon Oct 17 00:00:00 EDT 2016

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.

The Journal of experimental medicine

Ma CS,Wong N,Rao G,Nguyen A,Avery DT,Payne K,Torpy J,O'Young P,Deenick E,Bustamante J,Puel A,Okada S,Kobayashi M,Martinez-Barricarte R,Elliott M,Sebnem Kilic S,El Baghdadi J,Minegishi Y,Bousfiha A,Robertson N,Hambleton S,Arkwright PD,French M,Blincoe AK,Hsu P,Campbell DE,Stormon MO,Wong M,Adelstein S,Fulcher DA,Cook MC,Stepensky P,Boztug K,Beier R,Ikincioğullari A,Ziegler JB,Gray P,Picard C,Boisson-Dupuis S,Phan TG,Grimbacher B,Warnatz K,Holland SM,Uzel G,Casanova JL,Tangye SG

Mon Jul 25 00:00:00 EDT 2016

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.

Proceedings of the National Academy of Sciences of the United States of America

Zhou Q,Yu X,Demirkaya E,Deuitch N,Stone D,Tsai WL,Kuehn HS,Wang H,Yang D,Park YH,Ombrello AK,Blake M,Romeo T,Remmers EF,Chae JJ,Mullikin JC,Güzel F,Milner JD,Boehm M,Rosenzweig SD,Gadina M,Welch SB,Özen S,Topaloglu R,Abinun M,Kastner DL,Aksentijevich I

Tue Sep 06 00:00:00 EDT 2016

Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.

Proceedings of the National Academy of Sciences of the United States of America

Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC

Tue Aug 16 00:00:00 EDT 2016

SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes.

Experimental & molecular medicine

Ha YJ,Choi YS,Kang EH,Shin K,Kim TK,Song YW,Lee YJ

Fri Jun 24 00:00:00 EDT 2016

Sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells.

Experimental & molecular medicine

Hong CY,Lee HJ,Choi NR,Jung SH,Vo MC,Hoang MD,Kim HJ,Lee JJ

Fri Aug 19 00:00:00 EDT 2016

ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.

Journal of immunology (Baltimore, Md. : 1950)

Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V

Sat Oct 01 00:00:00 EDT 2016

Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth.

Biology of reproduction

Nadeau-Vallée M,Boudreault A,Leimert K,Hou X,Obari D,Madaan A,Rouget R,Zhu T,Belarbi L,Brien MÈ,Beaudry-Richard A,Olson DM,Girard S,Chemtob S

200-01B was used in Cell Culture to study the expression and function of NmU-R2, NmU and NmS in gestational tissues.

Thu Sep 01 00:00:00 EDT 2016

Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation.

Scientific reports

Liu L,Sun Q,Bao R,Roth M,Zhong B,Lan X,Tian J,He Q,Li D,Sun J,Yang X,Lu S

Thu Feb 25 00:00:00 EST 2016

Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFκB and PKC-α signaling.

Scientific reports

Chandrika G,Natesh K,Ranade D,Chugh A,Shastry P

Fri Mar 04 00:00:00 EST 2016

Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.

The Journal of biological chemistry

Doherty CM,Visse R,Dinakarpandian D,Strickland DK,Nagase H,Troeberg L

Fri Oct 14 00:00:00 EDT 2016

Isolation of highly enriched primary human microglia for functional studies.

Scientific reports

Rustenhoven J,Park TI,Schweder P,Scotter J,Correia J,Smith AM,Gibbons HM,Oldfield RL,Bergin PS,Mee EW,Faull RL,Curtis MA,Scott Graham E,Dragunow M

Mon Jan 18 00:00:00 EST 2016

Differential expression of p38 MAPK α, β, γ, δ isoforms in nucleus pulposus modulates macrophage polarization in intervertebral disc degeneration.

Scientific reports

Yang C,Cao P,Gao Y,Wu M,Lin Y,Tian Y,Yuan W

Thu Feb 25 00:00:00 EST 2016

Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action.

Scientific reports

Lombardo G,Dentelli P,Togliatto G,Rosso A,Gili M,Gallo S,Deregibus MC,Camussi G,Brizzi MF

Mon May 09 00:00:00 EDT 2016

Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.

Scientific reports

Hu B,Shi C,Xu C,Cao P,Tian Y,Zhang Y,Deng L,Chen H,Yuan W

Mon Feb 15 00:00:00 EST 2016

Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.

The Journal of biological chemistry

Mei ZZ,Chen XY,Hu SW,Wang N,Ou XL,Wang J,Luo HH,Liu J,Jiang Y

Fri Aug 26 00:00:00 EDT 2016

Nerve Growth Factor Is Regulated by Toll-Like Receptor 2 in Human Intervertebral Discs.

The Journal of biological chemistry

Krock E,Currie JB,Weber MH,Ouellet JA,Stone LS,Rosenzweig DH,Haglund L

Fri Feb 12 00:00:00 EST 2016

RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.

Scientific reports

Drujont L,Lemoine A,Moreau A,Bienvenu G,Lancien M,Cens T,Guillot F,Bériou G,Bouchet-Delbos L,Fehling HJ,Chiffoleau E,Nicot AB,Charnet P,Martin JC,Josien R,Cuturi MC,Louvet C

Thu Mar 24 00:00:00 EDT 2016

A novel role for β2-microglobulin: a precursor of antibacterial chemokine in respiratory epithelial cells.

Scientific reports

Chiou SJ,Wang CC,Tseng YS,Lee YJ,Chen SC,Chou CH,Chuang LY,Hong YR,Lu CY,Chiu CC,Chignard M

Tue Aug 09 00:00:00 EDT 2016

The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction.

Scientific reports

Villalvilla A,García-Martín A,Largo R,Gualillo O,Herrero-Beaumont G,Gómez R

Thu Jul 07 00:00:00 EDT 2016

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.

Nature communications

Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM

Mon Nov 21 00:00:00 EST 2016

Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.

Cell death & disease

Szatmári-Tóth M,Kristóf E,Veréb Z,Akhtar S,Facskó A,Fésüs L,Kauppinen A,Kaarniranta K,Petrovski G

Thu Sep 08 00:00:00 EDT 2016

Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease.

Scientific reports

Kumagai E,Mano Y,Yoshio S,Shoji H,Sugiyama M,Korenaga M,Ishida T,Arai T,Itokawa N,Atsukawa M,Hyogo H,Chayama K,Ohashi T,Ito K,Yoneda M,Kawaguchi T,Torimura T,Nozaki Y,Watanabe S,Mizokami M,Kanto T

Fri Oct 14 00:00:00 EDT 2016

A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis.

Scientific reports

Xu W,Xie Y,Wang Q,Wang X,Luo F,Zhou S,Wang Z,Huang J,Tan Q,Jin M,Qi H,Tang J,Chen L,Du X,Zhao C,Liang G,Chen L

Mon Apr 04 00:00:00 EDT 2016

PGE₂ is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.

Scientific reports

Fujii S,Suzuki K,Kawamoto A,Ishibashi F,Nakata T,Murano T,Ito G,Shimizu H,Mizutani T,Oshima S,Tsuchiya K,Nakamura T,Araki A,Ohtsuka K,Okamoto R,Watanabe M

Wed Nov 09 00:00:00 EST 2016

Double-edged-sword effect of IL-1β on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-κB, MAPK and BMP/Smad signaling pathways.

Cell death & disease

Mao CY,Wang YG,Zhang X,Zheng XY,Tang TT,Lu EY

Thu Jul 14 00:00:00 EDT 2016

The small tellurium-based compound SAS suppresses inflammation in human retinal pigment epithelium.

Molecular vision

Dardik R,Livnat T,Halpert G,Jawad S,Nisgav Y,Azar-Avivi S,Liu B,Nussenblatt RB,Weinberger D,Sredni B

Tue Nov 08 00:00:00 EST 2016

Endothelial-to-mesenchymal transition drives atherosclerosis progression.

The Journal of clinical investigation

Chen PY,Qin L,Baeyens N,Li G,Afolabi T,Budatha M,Tellides G,Schwartz MA,Simons M

Mon Oct 26 00:00:00 EDT 2015

Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.

The Journal of clinical investigation

Zhang Z,Cheng L,Zhao J,Li G,Zhang L,Chen W,Nie W,Reszka-Blanco NJ,Wang FS,Su L

Tue Sep 01 00:00:00 EDT 2015

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.

The Journal of experimental medicine

Wilson RP,Ives ML,Rao G,Lau A,Payne K,Kobayashi M,Arkwright PD,Peake J,Wong M,Adelstein S,Smart JM,French MA,Fulcher DA,Picard C,Bustamante J,Boisson-Dupuis S,Gray P,Stepensky P,Warnatz K,Freeman AF,Rossjohn J,McCluskey J,Holland SM,Casanova JL,Uzel G,Ma CS,Tangye SG,Deenick EK

Mon Jun 01 00:00:00 EDT 2015

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Proceedings of the National Academy of Sciences of the United States of America

Hammitzsch A,Tallant C,Fedorov O,O'Mahony A,Brennan PE,Hay DA,Martinez FO,Al-Mossawi MH,de Wit J,Vecellio M,Wells C,Wordsworth P,Müller S,Knapp S,Bowness P

Tue Aug 25 00:00:00 EDT 2015

Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal.

Proceedings of the National Academy of Sciences of the United States of America

De S,Zhou H,DeSantis D,Croniger CM,Li X,Stark GR

Tue Aug 04 00:00:00 EDT 2015

Crohn's disease-derived monocytes fail to induce Paneth cell defensins.

Proceedings of the National Academy of Sciences of the United States of America

Courth LF,Ostaff MJ,Mailänder-Sánchez D,Malek NP,Stange EF,Wehkamp J

Tue Nov 10 00:00:00 EST 2015

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.

Proceedings of the National Academy of Sciences of the United States of America

Schwartz MP,Hou Z,Propson NE,Zhang J,Engstrom CJ,Santos Costa V,Jiang P,Nguyen BK,Bolin JM,Daly W,Wang Y,Stewart R,Page CD,Murphy WL,Thomson JA

Tue Oct 06 00:00:00 EDT 2015

Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2.

Mucosal immunology

Cobo ER,Kissoon-Singh V,Moreau F,Chadee K

Sun Nov 01 00:00:00 EDT 2015

Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.

Acta physiologica (Oxford, England)

Jean-Gilles L,Braitch M,Latif ML,Aram J,Fahey AJ,Edwards LJ,Robins RA,Tanasescu R,Tighe PJ,Gran B,Showe LC,Alexander SP,Chapman V,Kendall DA,Constantinescu CS

Fri May 01 00:00:00 EDT 2015

Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.

Journal of lipid research

Benesch MG,Zhao YY,Curtis JM,McMullen TP,Brindley DN

Mon Jun 01 00:00:00 EDT 2015

Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils.

Journal of leukocyte biology

De Buck M,Berghmans N,Pörtner N,Vanbrabant L,Cockx M,Struyf S,Opdenakker G,Proost P,Van Damme J,Gouwy M

Tue Dec 01 00:00:00 EST 2015

In Vivo Identification and Induction of Articular Cartilage Stem Cells by Inhibiting NF-κB Signaling in Osteoarthritis.

Stem cells (Dayton, Ohio)

Tong W,Geng Y,Huang Y,Shi Y,Xiang S,Zhang N,Qin L,Shi Q,Chen Q,Dai K,Zhang X

Thu Oct 01 00:00:00 EDT 2015

Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Chadet S,Ivanes F,Benoist L,Salmon-Gandonnière C,Guibon R,Velge-Roussel F,Babuty D,Baron C,Roger S,Angoulvant D

Wed Jul 15 00:00:00 EDT 2015

Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.

Journal of immunology (Baltimore, Md. : 1950)

Nadeau-Vallée M,Quiniou C,Palacios J,Hou X,Erfani A,Madaan A,Sanchez M,Leimert K,Boudreault A,Duhamel F,Rivera JC,Zhu T,Noueihed B,Robertson SA,Ni X,Olson DM,Lubell W,Girard S,Chemtob S

Thu Oct 01 00:00:00 EDT 2015

Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.

Journal of immunology (Baltimore, Md. : 1950)

Nadeau-Vallée M,Quiniou C,Palacios J,Hou X,Erfani A,Madaan A,Sanchez M,Leimert K,Boudreault A,Duhamel F,Rivera JC,Zhu T,Noueihed B,Robertson SA,Ni X,Olson DM,Lubell W,Girard S,Chemtob S

Thu Oct 01 00:00:00 EDT 2015

Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.

Journal of immunology (Baltimore, Md. : 1950)

Lourenco S,Teixeira VH,Kalber T,Jose RJ,Floto RA,Janes SM

Wed Apr 01 00:00:00 EDT 2015

Profiling T cell activation using single-molecule fluorescence in situ hybridization and flow cytometry.

Journal of immunology (Baltimore, Md. : 1950)

Bushkin Y,Radford F,Pine R,Lardizabal A,Mangura BT,Gennaro ML,Tyagi S

Thu Jan 15 00:00:00 EST 2015

Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signaling.

Journal of immunology (Baltimore, Md. : 1950)

Larena M,Holmgren J,Lebens M,Terrinoni M,Lundgren A

Wed Apr 15 00:00:00 EDT 2015

Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9.

Journal of immunology (Baltimore, Md. : 1950)

Lai CY,Yeh DW,Lu CH,Liu YL,Huang LR,Kao CY,Chen HY,Huang CY,Chang CH,Luo Y,Xiang R,Chuang TH

Thu Oct 15 00:00:00 EDT 2015

Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Takami M,Fujimaki K,Nishimura MI,Iwashima M

Tue Sep 15 00:00:00 EDT 2015

Allergenic Can f 1 and its human homologue Lcn-1 direct dendritic cells to induce divergent immune responses.

Journal of cellular and molecular medicine

Posch B,Irsara C,Gamper FS,Herrmann M,Bindreither D,Fuchs D,Reider N,Redl B,Heufler C

Thu Oct 01 00:00:00 EDT 2015

Network-Based Analysis of Nutraceuticals in Human Hepatocellular Carcinomas Reveals Mechanisms of Chemopreventive Action.

CPT: pharmacometrics & systems pharmacology

Michailidou M,Melas IN,Messinis DE,Klamt S,Alexopoulos LG,Kolisis FN,Loutrari H

Mon Jun 01 00:00:00 EDT 2015

Lithium chloride prevents interleukin-1β induced cartilage degradation and loss of mechanical properties.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Thompson CL,Yasmin H,Varone A,Wiles A,Poole CA,Knight MM

Thu Oct 01 00:00:00 EDT 2015

Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.

Scientific reports

Liu J,Zhou F,Chen Q,Kang A,Lu M,Liu W,Zang X,Wang G,Zhang J

Tue Sep 01 00:00:00 EDT 2015

Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION.

The Journal of biological chemistry

Burzynski LC,Humphry M,Bennett MR,Clarke MC

Fri Oct 09 00:00:00 EDT 2015

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.

Nature communications

Riesenberg S,Groetchen A,Siddaway R,Bald T,Reinhardt J,Smorra D,Kohlmeyer J,Renn M,Phung B,Aymans P,Schmidt T,Hornung V,Davidson I,Goding CR,Jönsson G,Landsberg J,Tüting T,Hölzel M

Wed Nov 04 00:00:00 EST 2015

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.

Nature communications

Wee ZN,Yatim SM,Kohlbauer VK,Feng M,Goh JY,Bao Y,Lee PL,Zhang S,Wang PP,Lim E,Tam WL,Cai Y,Ditzel HJ,Hoon DS,Tan EY,Yu Q

Tue Oct 27 00:00:00 EDT 2015

MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins.

The Journal of biological chemistry

Park H,Huang X,Lu C,Cairo MS,Zhou X

Fri Jan 30 00:00:00 EST 2015

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.

Scientific reports

Mailer RK,Joly AL,Liu S,Elias S,Tegner J,Andersson J

Tue Oct 06 00:00:00 EDT 2015

The Role of MicroRNA-381 in Chondrogenesis and Interleukin-1-β Induced Chondrocyte Responses.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Hou C,Meng F,Zhang Z,Kang Y,Chen W,Huang G,Fu M,Sheng P,Zhang Z,Liao W

200-01B was used in In vitro experiments to examine its role in chondrogenesis and osteoarthritic cartilage degeneration.

Mon May 16 00:00:00 EDT 2016

The Role of MicroRNA-381 in Chondrogenesis and Interleukin-1-β Induced Chondrocyte Responses.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Hou C,Meng F,Zhang Z,Kang Y,Chen W,Huang G,Fu M,Sheng P,Zhang Z,Liao W

200-01B was used in In vitro experiments to examine its role in chondrogenesis and osteoarthritic cartilage degeneration.

Mon May 16 00:00:00 EDT 2016

An anti-inflammatory role for C/EBPδ in human brain pericytes.

Scientific reports

Rustenhoven J,Scotter EL,Jansson D,Kho DT,Oldfield RL,Bergin PS,Mee EW,Faull RL,Curtis MA,Graham SE,Park TI,Dragunow M

Mon Jul 13 00:00:00 EDT 2015

Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis.

Scientific reports

Zhu H,Wan X,Li J,Han L,Bo X,Chen W,Lu C,Shen Z,Xu C,Chen L,Yu C,Xu G

Fri Jul 17 00:00:00 EDT 2015

Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression.

The Journal of biological chemistry

Tsukuda S,Watashi K,Iwamoto M,Suzuki R,Aizaki H,Okada M,Sugiyama M,Kojima S,Tanaka Y,Mizokami M,Li J,Tong S,Wakita T

Fri Feb 27 00:00:00 EST 2015

TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance.

Oncoimmunology

Guerville F,Daburon S,Marlin R,Lartigue L,Loizon S,Pitard V,Couzi L,Moreau JF,Déchanet-Merville J,Faustin B

200-01B was used in In vitro experiments to investigate the relationship between inflammasome secreted by tumor cells and γδ cell immusurveillance.

Fri May 01 00:00:00 EDT 2015

A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.

Arthritis & rheumatology (Hoboken, N.J.)

Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L

Fri Aug 01 00:00:00 EDT 2014

IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.

Proceedings of the National Academy of Sciences of the United States of America

Ben-Addi A,Mambole-Dema A,Brender C,Martin SR,Janzen J,Kjaer S,Smerdon SJ,Ley SC

Tue Jun 10 00:00:00 EDT 2014

EGF receptor uses SOS1 to drive constitutive activation of NFκB in cancer cells.

Proceedings of the National Academy of Sciences of the United States of America

De S,Dermawan JK,Stark GR

Tue Aug 12 00:00:00 EDT 2014

Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction.

British journal of cancer

Nagasaki T,Hara M,Nakanishi H,Takahashi H,Sato M,Takeyama H

Tue Jan 21 00:00:00 EST 2014

Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response.

Stem cells (Dayton, Ohio)

De Kock J,Meuleman P,Raicevic G,Rodrigues RM,Branson S,Meganathan K,De Boe V,Sachinidis A,Leroux-Roels G,Vanhaecke T,Lagneaux L,Rogiers V,Najar M

Fri Aug 01 00:00:00 EDT 2014

Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Mota C,Nunes-Silva V,Pires AR,Matoso P,Victorino RM,Sousa AE,Caramalho I

Mon Dec 15 00:00:00 EST 2014

Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses.

Journal of immunology (Baltimore, Md. : 1950)

Epaulard O,Adam L,Poux C,Zurawski G,Salabert N,Rosenbaum P,Dereuddre-Bosquet N,Zurawski S,Flamar AL,Oh S,Romain G,Chapon C,Banchereau J,Lévy Y,Le Grand R,Martinon F

Mon Sep 01 00:00:00 EDT 2014

Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.

Journal of immunology (Baltimore, Md. : 1950)

Yu J,Wang Y,Yan F,Zhang P,Li H,Zhao H,Yan C,Yan F,Ren X

Mon Sep 01 00:00:00 EDT 2014

Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation.

Journal of immunology (Baltimore, Md. : 1950)

Gu M,Ouyang C,Lin W,Zhang T,Cao X,Xia Z,Wang X

Sat Mar 15 00:00:00 EDT 2014

IL-2 phosphorylates STAT5 to drive IFN-γ production and activation of human dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Herr F,Lemoine R,Gouilleux F,Meley D,Kazma I,Heraud A,Velge-Roussel F,Baron C,Lebranchu Y

Sun Jun 15 00:00:00 EDT 2014

Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.

Journal of immunology (Baltimore, Md. : 1950)

Dreymueller D,Martin C,Schumacher J,Groth E,Boehm JK,Reiss LK,Uhlig S,Ludwig A

Wed Jan 15 00:00:00 EST 2014

A negative feedback loop mediated by STAT3 limits human Th17 responses.

Journal of immunology (Baltimore, Md. : 1950)

Purvis HA,Anderson AE,Young DA,Isaacs JD,Hilkens CM

Fri Aug 01 00:00:00 EDT 2014

Modulation of TNF-induced macrophage polarization by synovial fibroblasts.

Journal of immunology (Baltimore, Md. : 1950)

Donlin LT,Jayatilleke A,Giannopoulou EG,Kalliolias GD,Ivashkiv LB

Mon Sep 01 00:00:00 EDT 2014

Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.

The Journal of biological chemistry

Zhang Y,Lei CQ,Hu YH,Xia T,Li M,Zhong B,Shu HB

Fri May 02 00:00:00 EDT 2014

Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.

The Journal of biological chemistry

Zhang Y,Lei CQ,Hu YH,Xia T,Li M,Zhong B,Shu HB

Fri May 02 00:00:00 EDT 2014

Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX).

The Journal of biological chemistry

Ouyang C,Nie L,Gu M,Wu A,Han X,Wang X,Shao J,Xia Z

Fri Aug 29 00:00:00 EDT 2014

Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.

The Journal of biological chemistry

Humphrey RK,Ray A,Gonuguntla S,Hao E,Jhala US

Fri Oct 24 00:00:00 EDT 2014

Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.

The Journal of biological chemistry

Humphrey RK,Ray A,Gonuguntla S,Hao E,Jhala US

Fri Oct 24 00:00:00 EDT 2014

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.

Nature communications

Burton BR,Britton GJ,Fang H,Verhagen J,Smithers B,Sabatos-Peyton CA,Carney LJ,Gough J,Strobel S,Wraith DC

Wed Sep 03 00:00:00 EDT 2014

CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration.

The Journal of biological chemistry

Tran CM,Schoepflin ZR,Markova DZ,Kepler CK,Anderson DG,Shapiro IM,Risbud MV

Fri Mar 14 00:00:00 EDT 2014

CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration.

The Journal of biological chemistry

Tran CM,Schoepflin ZR,Markova DZ,Kepler CK,Anderson DG,Shapiro IM,Risbud MV

Fri Mar 14 00:00:00 EDT 2014

Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.

PloS one

Zhang YY,Chen H,Sun C,Wang HZ,Liu ML,Li YY,Nie XL,Du MR,Li DJ,Zhang JP

200-01B was used in In vitro experiments to investigate the effects of NOD2 expression on the maternal-fetal relationship in normal decidual stromal cells.

Thu Oct 22 00:00:00 EDT 2015

Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.

PloS one

Zhang YY,Chen H,Sun C,Wang HZ,Liu ML,Li YY,Nie XL,Du MR,Li DJ,Zhang JP

200-01B was used in In vitro experiments to investigate the effects of NOD2 expression on the maternal-fetal relationship in normal decidual stromal cells.

Thu Oct 22 00:00:00 EDT 2015

Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells.

The Journal of biological chemistry

Oleson BJ,Broniowska KA,Schreiber KH,Tarakanova VL,Corbett JA

Fri Apr 18 00:00:00 EDT 2014

N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization.

The Journal of biological chemistry

Abe T,Kojima M,Akanuma S,Iwashita H,Yamazaki T,Okuyama R,Ichikawa K,Umemura M,Nakano H,Takahashi S,Takahashi Y

Fri Feb 14 00:00:00 EST 2014

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.

BMC cancer

Leibovich-Rivkin T,Liubomirski Y,Meshel T,Abashidze A,Brisker D,Solomon H,Rotter V,Weil M,Ben-Baruch A

200-01B was used in Sample Preparation (ELISA) to determine the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The inflammatory cytokines TNFα and IL-1β, shown in our published studies to be highly expressed in tumors of >80% of breast cancer patients with recurrent disease.

Thu Mar 06 00:00:00 EST 2014

Interleukin-1β promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production.

Cell death & disease

Sun W,Depping R,Jelkmann W

Thu Jan 23 00:00:00 EST 2014

High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

Scientific reports

Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ

Wed Apr 23 00:00:00 EDT 2014

Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions.

Blood

Matta J,Baratin M,Chiche L,Forel JM,Cognet C,Thomas G,Farnarier C,Piperoglou C,Papazian L,Chaussabel D,Ugolini S,Vély F,Vivier E

Thu Jul 18 00:00:00 EDT 2013

Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions.

The Journal of clinical investigation

Aziz A,Baxter EJ,Edwards C,Cheong CY,Ito M,Bench A,Kelley R,Silber Y,Beer PA,Chng K,Renfree MB,McEwen K,Gray D,Nangalia J,Mufti GJ,Hellstrom-Lindberg E,Kiladjian JJ,McMullin MF,Campbell PJ,Ferguson-Smith AC,Green AR

Wed May 01 00:00:00 EDT 2013

CXCL5 limits macrophage foam cell formation in atherosclerosis.

The Journal of clinical investigation

Rousselle A,Qadri F,Leukel L,Yilmaz R,Fontaine JF,Sihn G,Bader M,Ahluwalia A,Duchene J

Fri Mar 01 00:00:00 EST 2013

MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.

The Journal of experimental medicine

Long HM,Chagoury OL,Leese AM,Ryan GB,James E,Morton LT,Abbott RJ,Sabbah S,Kwok W,Rickinson AB

Mon May 06 00:00:00 EDT 2013

USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.

The Journal of experimental medicine

Liu X,Li H,Zhong B,Blonska M,Gorjestani S,Yan M,Tian Q,Zhang DE,Lin X,Dong C

Mon Jul 29 00:00:00 EDT 2013

Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.

Proceedings of the National Academy of Sciences of the United States of America

Fu B,Li X,Sun R,Tong X,Ling B,Tian Z,Wei H

Tue Jan 15 00:00:00 EST 2013

Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells.

PLoS pathogens

Chen Y,Hwang SL,Chan VS,Chung NP,Wang SR,Li Z,Ma J,Lin CW,Hsieh YJ,Chang KP,Kung SS,Wu YC,Chu CW,Tai HT,Gao GF,Zheng B,Yokoyama KK,Austyn JM,Lin CL

Tue Jan 01 00:00:00 EST 2013

Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.

PLoS pathogens

Mansur DS,Maluquer de Motes C,Unterholzner L,Sumner RP,Ferguson BJ,Ren H,Strnadova P,Bowie AG,Smith GL

Fri Feb 01 00:00:00 EST 2013

Trp53 deficiency protects against acute intestinal inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Spehlmann ME,Manthey CF,Dann SM,Hanson E,Sandhu SS,Liu LY,Abdelmalak FK,Diamanti MA,Retzlaff K,Scheller J,Rose-John S,Greten FR,Wang JY,Eckmann L

Mon Jul 15 00:00:00 EDT 2013

An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R

Tue Jan 01 00:00:00 EST 2013

TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.

PloS one

Liu Y,Yu S,Li Z,Ma J,Zhang Y,Wang H,Yang B,Wu C

Tue Feb 18 00:00:00 EST 2014

Immunologic targeting of FOXP3 in inflammatory breast cancer cells.

PloS one

Nair S,Aldrich AJ,McDonnell E,Cheng Q,Aggarwal A,Patel P,Williams MM,Boczkowski D,Lyerly HK,Morse MA,Devi GR

Tue Jul 09 00:00:00 EDT 2013

Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.

PloS one

Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T

Fri Sep 06 00:00:00 EDT 2013

Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death.

The Journal of biological chemistry

Humphrey RK,Yu SM,Bellary A,Gonuguntla S,Yebra M,Jhala US

Fri Jan 25 00:00:00 EST 2013

Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage.

The Journal of biological chemistry

Yan D,Kc R,Chen D,Xiao G,Im HJ

Fri Nov 01 00:00:00 EDT 2013

Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.

The Journal of biological chemistry

Ferreira E,Porter RM,Wehling N,O'Sullivan RP,Liu F,Boskey A,Estok DM,Harris MB,Vrahas MS,Evans CH,Wells JW

Fri Oct 11 00:00:00 EDT 2013

Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.

The Journal of biological chemistry

Wang H,Tian Y,Wang J,Phillips KLE,Binch ALA,Dunn S,Cross A,Chiverton N,Zheng Z,Shapiro IM,Le Maitre CL,Risbud MV

Fri Jun 07 00:00:00 EDT 2013

Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.

The Journal of biological chemistry

Wang H,Tian Y,Wang J,Phillips KLE,Binch ALA,Dunn S,Cross A,Chiverton N,Zheng Z,Shapiro IM,Le Maitre CL,Risbud MV

Fri Jun 07 00:00:00 EDT 2013

Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis.

The Journal of biological chemistry

Ingvarsen S,Porse A,Erpicum C,Maertens L,Jürgensen HJ,Madsen DH,Melander MC,Gårdsvoll H,Høyer-Hansen G,Noel A,Holmbeck K,Engelholm LH,Behrendt N

Fri Apr 12 00:00:00 EDT 2013

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.

Nature

Landsberg J,Kohlmeyer J,Renn M,Bald T,Rogava M,Cron M,Fatho M,Lennerz V,Wölfel T,Hölzel M,Tüting T

Thu Oct 18 00:00:00 EDT 2012

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Blood

Ma CS,Avery DT,Chan A,Batten M,Bustamante J,Boisson-Dupuis S,Arkwright PD,Kreins AY,Averbuch D,Engelhard D,Magdorf K,Kilic SS,Minegishi Y,Nonoyama S,French MA,Choo S,Smart JM,Peake J,Wong M,Gray P,Cook MC,Fulcher DA,Casanova JL,Deenick EK,Tangye SG

Thu Apr 26 00:00:00 EDT 2012

Mast cells play a protumorigenic role in primary cutaneous lymphoma.

Blood

Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K

Thu Sep 06 00:00:00 EDT 2012

Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function.

Blood

Dannull J,Schneider T,Lee WT,de Rosa N,Tyler DS,Pruitt SK

Thu Mar 29 00:00:00 EDT 2012

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.

The Journal of clinical investigation

Argaw AT,Asp L,Zhang J,Navrazhina K,Pham T,Mariani JN,Mahase S,Dutta DJ,Seto J,Kramer EG,Ferrara N,Sofroniew MV,John GR

Sun Jul 01 00:00:00 EDT 2012

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.

The Journal of experimental medicine

Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ

Mon Jan 16 00:00:00 EST 2012

IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.

Proceedings of the National Academy of Sciences of the United States of America

Rossato M,Curtale G,Tamassia N,Castellucci M,Mori L,Gasperini S,Mariotti B,De Luca M,Mirolo M,Cassatella MA,Locati M,Bazzoni F

Tue Nov 06 00:00:00 EST 2012

K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.

Proceedings of the National Academy of Sciences of the United States of America

Singh K,Deshpande P,Li G,Yu M,Pryshchep S,Cavanagh M,Weyand CM,Goronzy JJ

Tue Jun 19 00:00:00 EDT 2012

Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.

Cancer immunology, immunotherapy : CII

Fowler DW,Copier J,Wilson N,Dalgleish AG,Bodman-Smith MD

Sun Apr 01 00:00:00 EDT 2012

Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease.

Arthritis research & therapy

Sugita S,Kawazoe Y,Imai A,Yamada Y,Horie S,Mochizuki M

Tue May 01 00:00:00 EDT 2012

Multiple receptors trigger human NK cell-mediated cytotoxicity against porcine chondrocytes.

Journal of immunology (Baltimore, Md. : 1950)

Sommaggio R,Cohnen A,Watzl C,Costa C

Thu Mar 01 00:00:00 EST 2012

Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.

Journal of immunology (Baltimore, Md. : 1950)

Jeffery LE,Wood AM,Qureshi OS,Hou TZ,Gardner D,Briggs Z,Kaur S,Raza K,Sansom DM

Sat Dec 01 00:00:00 EST 2012

Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.

Journal of immunology (Baltimore, Md. : 1950)

Kuckleburg CJ,Tilkens SB,Santoso S,Newman PJ

Thu Mar 01 00:00:00 EST 2012

Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.

Journal of immunology (Baltimore, Md. : 1950)

Young A,Linehan E,Hams E,O'Hara Hall AC,McClurg A,Johnston JA,Hunter CA,Fallon PG,Fitzgerald DC

Sat Sep 01 00:00:00 EDT 2012

Corticotropin releasing factor-1 receptor antagonism alters the biochemical, but not behavioral effects of repeated interleukin-1β administration.

Neuropharmacology

Wilhelm CJ,Murphy-Crews A,Menasco DJ,Huckans MS,Loftis JM

200-01B was used in In vivo experiments to show that additional studies will be needed to determine whether CRF(1) antagonism is an effective treatment for cytokine-induced sickness.

Sun Jan 01 00:00:00 EST 2012

Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCδ pathway in human articular chondrocytes.

Journal of cellular biochemistry

Yan D,Chen D,Im HJ

Sat Sep 01 00:00:00 EDT 2012

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.

The Biochemical journal

Whitehead MA,Bombardieri M,Pitzalis C,Vanhaesebroeck B

Tue May 01 00:00:00 EDT 2012

Characterization of the autocrine/paracrine function of vitamin D in human gingival fibroblasts and periodontal ligament cells.

PloS one

Liu K,Meng H,Hou J

Fri Jan 04 00:00:00 EST 2013

DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.

PloS one

Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H

Thu Nov 08 00:00:00 EST 2012

Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity.

Journal of inflammation (London, England)

Klawitter M,Quero L,Klasen J,Gloess AN,Klopprogge B,Hausmann O,Boos N,Wuertz K

Tue Aug 21 00:00:00 EDT 2012

Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.

PloS one

Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC

Fri Jun 29 00:00:00 EDT 2012

Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).

PloS one

Suh HS,Choi N,Tarassishin L,Lee SC

Tue Aug 07 00:00:00 EDT 2012

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

The Journal of biological chemistry

Lohse S,Brunke C,Derer S,Peipp M,Boross P,Kellner C,Beyer T,Dechant M,van der Winkel JG,Leusen JH,Valerius T

Fri Jul 20 00:00:00 EDT 2012

MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.

PloS one

Iyer A,Zurolo E,Prabowo A,Fluiter K,Spliet WG,van Rijen PC,Gorter JA,Aronica E

Tue Mar 05 00:00:00 EST 2013

Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion.

BMC biotechnology

Liu M,Huang Y,Hu L,Liu G,Hu X,Liu D,Yang X

Tue Sep 25 00:00:00 EDT 2012

The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers.

BMC cancer

Wang J,Xu K,Wu J,Luo C,Li Y,Wu X,Gao H,Feng G,Yuan BZ

Fri Sep 21 00:00:00 EDT 2012

Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.

PloS one

Tsuda K,Yamanaka K,Kitagawa H,Akeda T,Naka M,Niwa K,Nakanishi T,Kakeda M,Gabazza EC,Mizutani H

Fri Aug 03 00:00:00 EDT 2012

Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1.

PloS one

Zhou J,Joplin DG,Cross JV,Templeton DJ

Thu Jun 20 00:00:00 EDT 2013

Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes.

PloS one

Shih KS,Wang JH,Wu YW,Teng CM,Chen CC,Yang CR

Mon Jan 14 00:00:00 EST 2013

Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes.

PloS one

Shih KS,Wang JH,Wu YW,Teng CM,Chen CC,Yang CR

Mon Jan 14 00:00:00 EST 2013

Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes.

PloS one

Shih KS,Wang JH,Wu YW,Teng CM,Chen CC,Yang CR

Mon Jan 14 00:00:00 EST 2013

Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations.

Cancers

Leibovich-Rivkin T,Buganim Y,Solomon H,Meshel T,Rotter V,Ben-Baruch A

200-01B was used in Cell Culture to use an unbiased model system to propose that inflammatory mediators of the tumor milieu have dominating roles over oncogenic modifications in dictating the expression of a pro-malignancy chemokine readout.

Fri Jan 20 00:00:00 EST 2012

Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations.

Cancers

Leibovich-Rivkin T,Buganim Y,Solomon H,Meshel T,Rotter V,Ben-Baruch A

Fri Jan 20 00:00:00 EST 2012

The Notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation.

The Journal of biological chemistry

Keuylian Z,de Baaij JH,Gueguen M,Glorian M,Rouxel C,Merlet E,Lipskaia L,Blaise R,Mateo V,Limon I

Fri Jul 20 00:00:00 EDT 2012

Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.

PloS one

Matta H,Gopalakrishnan R,Graham C,Tolani B,Khanna A,Yi H,Suo Y,Chaudhary PM

Wed Sep 19 00:00:00 EDT 2012

The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.

Annals of the rheumatic diseases

Valdes AM,De Wilde G,Doherty SA,Lories RJ,Vaughn FL,Laslett LL,Maciewicz RA,Soni A,Hart DJ,Zhang W,Muir KR,Dennison EM,Wheeler M,Leaverton P,Cooper C,Spector TD,Cicuttini FM,Chapman V,Jones G,Arden NK,Doherty M

Thu Sep 01 00:00:00 EDT 2011

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.

Blood

Bosco MC,Pierobon D,Blengio F,Raggi F,Vanni C,Gattorno M,Eva A,Novelli F,Cappello P,Giovarelli M,Varesio L

Thu Mar 03 00:00:00 EST 2011

A novel pro-lymphangiogenic function for Th17/IL-17.

Blood

Chauhan SK,Jin Y,Goyal S,Lee HS,Fuchsluger TA,Lee HK,Dana R

Thu Oct 27 00:00:00 EDT 2011

STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.

Blood

Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E

Thu Jan 06 00:00:00 EST 2011

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.

Nature protocols

Choi KD,Vodyanik M,Slukvin II

200-01B was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.

Tue Mar 01 00:00:00 EST 2011

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.

Nature protocols

Choi KD,Vodyanik M,Slukvin II

200-01B was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.

Tue Mar 01 00:00:00 EST 2011

Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.

PLoS pathogens

Maluquer de Motes C,Cooray S,Ren H,Almeida GM,McGourty K,Bahar MW,Stuart DI,Grimes JM,Graham SC,Smith GL

Thu Dec 01 00:00:00 EST 2011

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.

PLoS pathogens

Eitz Ferrer P,Potthoff S,Kirschnek S,Gasteiger G,Kastenmüller W,Ludwig H,Paschen SA,Villunger A,Sutter G,Drexler I,Häcker G

Wed Jun 01 00:00:00 EDT 2011

Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells.

Journal of immunology (Baltimore, Md. : 1950)

Lee JH,Ulrich B,Cho J,Park J,Kim CH

Mon Aug 15 00:00:00 EDT 2011

Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Campbell IK,van Nieuwenhuijze A,Segura E,O'Donnell K,Coghill E,Hommel M,Gerondakis S,Villadangos JA,Wicks IP

Sun May 01 00:00:00 EDT 2011

Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.

Journal of immunology (Baltimore, Md. : 1950)

Okano S,Yonemitsu Y,Shirabe K,Kakeji Y,Maehara Y,Harada M,Yoshikai Y,Inoue M,Hasegawa M,Sueishi K

Tue Feb 01 00:00:00 EST 2011

IL-1β is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease.

Journal of immunology (Baltimore, Md. : 1950)

Pathak S,Goldofsky E,Vivas EX,Bonagura VR,Vambutas A

Tue Feb 01 00:00:00 EST 2011

The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Ortner D,Grabher D,Hermann M,Kremmer E,Hofer S,Heufler C

Sat Oct 15 00:00:00 EDT 2011

Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential.

Stem cells international

Auletta JJ,Zale EA,Welter JF,Solchaga LA

Thu Mar 03 00:00:00 EST 2011

A novel TLR3 inhibitor encoded by African swine fever virus (ASFV).

Archives of virology

de Oliveira VL,Almeida SC,Soares HR,Crespo A,Marshall-Clarke S,Parkhouse RM

Fri Apr 01 00:00:00 EDT 2011

Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa.

PloS one

Harel E,Rubinstein A,Nissan A,Khazanov E,Nadler Milbauer M,Barenholz Y,Tirosh B

Tue Feb 14 00:00:00 EST 2012

Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.

The Journal of biological chemistry

Benfield CT,Mansur DS,McCoy LE,Ferguson BJ,Bahar MW,Oldring AP,Grimes JM,Stuart DI,Graham SC,Smith GL

Fri Jun 10 00:00:00 EDT 2011

ST2 and IL-33 in pregnancy and pre-eclampsia.

PloS one

Granne I,Southcombe JH,Snider JV,Tannetta DS,Child T,Redman CW,Sargent IL

Fri Feb 03 00:00:00 EST 2012

LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).

PloS one

An H,Lu X,Liu D,Yarbrough WG

Mon Jan 24 00:00:00 EST 2011

Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α.

BMC genomics

Wang Z,Bishop EP,Burke PA

Fri Feb 25 00:00:00 EST 2011

FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide.

The Journal of biological chemistry

Hughes KJ,Meares GP,Hansen PA,Corbett JA

Fri Mar 11 00:00:00 EST 2011

Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways.

Journal of neuroinflammation

Green JA,Dholakia S,Janczar K,Ong CW,Moores R,Fry J,Elkington PT,Roncaroli F,Friedland JS

Wed May 11 00:00:00 EDT 2011

Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.

The Journal of biological chemistry

Lobito AA,Ramani SR,Tom I,Bazan JF,Luis E,Fairbrother WJ,Ouyang W,Gonzalez LC

Fri May 27 00:00:00 EDT 2011

Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression.

BMC complementary and alternative medicine

Schwager J,Hoeller U,Wolfram S,Richard N

Thu Nov 03 00:00:00 EDT 2011

The CD157-integrin partnership controls transendothelial migration and adhesion of human monocytes.

The Journal of biological chemistry

Lo Buono N,Parrotta R,Morone S,Bovino P,Nacci G,Ortolan E,Horenstein AL,Inzhutova A,Ferrero E,Funaro A

Fri May 27 00:00:00 EDT 2011

TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.

The Journal of biological chemistry

Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV

Fri Nov 18 00:00:00 EST 2011

TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.

The Journal of biological chemistry

Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV

Fri Nov 18 00:00:00 EST 2011

Function of partially duplicated human α77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response.

The Journal of biological chemistry

de Lucas-Cerrillo AM,Maldifassi MC,Arnalich F,Renart J,Atienza G,Serantes R,Cruces J,Sánchez-Pacheco A,Andrés-Mateos E,Montiel C

Fri Jan 07 00:00:00 EST 2011

Control of cell migration and inflammatory mediators production by CORM-2 in osteoarthritic synoviocytes.

PloS one

García-Arnandis I,Guillén MI,Gomar F,Castejón MA,Alcaraz MJ

Thu Mar 01 00:00:00 EST 2012

IκB kinase β regulates epithelium migration during corneal wound healing.

PloS one

Chen L,Meng Q,Kao W,Xia Y

Mon Jan 17 00:00:00 EST 2011

Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro.

PloS one

Mokhtari D,Li T,Lu T,Welsh N

Tue Feb 28 00:00:00 EST 2012

Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.

PloS one

Jham BC,Ma T,Hu J,Chaisuparat R,Friedman ER,Pandolfi PP,Schneider A,Sodhi A,Montaner S

Fri Apr 29 00:00:00 EDT 2011

Deactivation of STAT6 through serine 707 phosphorylation by JNK.

The Journal of biological chemistry

Shirakawa T,Kawazoe Y,Tsujikawa T,Jung D,Sato S,Uesugi M

Fri Feb 04 00:00:00 EST 2011

Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism.

Cell death & disease

Donadelli M,Dando I,Zaniboni T,Costanzo C,Dalla Pozza E,Scupoli MT,Scarpa A,Zappavigna S,Marra M,Abbruzzese A,Bifulco M,Caraglia M,Palmieri M

Thu Apr 28 00:00:00 EDT 2011

Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HβD2 gene expression and IL-8 release.

PloS one

Davidson LB,Nessar R,Kempaiah P,Perkins DJ,Byrd TF

Mon May 21 00:00:00 EDT 2012

Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway.

Journal of neuroinflammation

Tarassishin L,Suh HS,Lee SC

Fri Dec 30 00:00:00 EST 2011

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.

PloS one

Di Meglio P,Di Cesare A,Laggner U,Chu CC,Napolitano L,Villanova F,Tosi I,Capon F,Trembath RC,Peris K,Nestle FO

Tue Feb 22 00:00:00 EST 2011

Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.

Immunity

Hughes T,Becknell B,Freud AG,McClory S,Briercheck E,Yu J,Mao C,Giovenzana C,Nuovo G,Wei L,Zhang X,Gavrilin MA,Wewers MD,Caligiuri MA

Fri Jun 25 00:00:00 EDT 2010

Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses.

Immunity

Blanchet FP,Moris A,Nikolic DS,Lehmann M,Cardinaud S,Stalder R,Garcia E,Dinkins C,Leuba F,Wu L,Schwartz O,Deretic V,Piguet V

Fri May 28 00:00:00 EDT 2010

Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.

Blood

Kondo A,Yamashita T,Tamura H,Zhao W,Tsuji T,Shimizu M,Shinya E,Takahashi H,Tamada K,Chen L,Dan K,Ogata K

Thu Aug 19 00:00:00 EDT 2010

Low-strength T-cell activation promotes Th17 responses.

Blood

Purvis HA,Stoop JN,Mann J,Woods S,Kozijn AE,Hambleton S,Robinson JH,Isaacs JD,Anderson AE,Hilkens CM

Thu Dec 02 00:00:00 EST 2010

Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity.

Proceedings of the National Academy of Sciences of the United States of America

Cella M,Otero K,Colonna M

Tue Jun 15 00:00:00 EDT 2010

An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells.

Human reproduction (Oxford, England)

King AE,Collins F,Klonisch T,Sallenave JM,Critchley HO,Saunders PT

Mon Feb 01 00:00:00 EST 2010

Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes.

The international journal of biochemistry & cell biology

Ali S,Singh NN,Yildirim H,Ramji DP

Fri Jan 01 00:00:00 EST 2010

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes.

Arthritis research & therapy

García-Arnandis I,Guillén MI,Gomar F,Pelletier JP,Martel-Pelletier J,Alcaraz MJ

Wed Jan 19 00:00:00 EST 2011

Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin.

Journal of immunology (Baltimore, Md. : 1950)

Bleck B,Tse DB,Gordon T,Ahsan MR,Reibman J

Wed Dec 01 00:00:00 EST 2010

Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.

Journal of immunology (Baltimore, Md. : 1950)

Green JA,Elkington PT,Pennington CJ,Roncaroli F,Dholakia S,Moores RC,Bullen A,Porter JC,Agranoff D,Edwards DR,Friedland JS

Tue Jun 01 00:00:00 EDT 2010

Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients.

Journal of immunology (Baltimore, Md. : 1950)

Kuang DM,Peng C,Zhao Q,Wu Y,Zhu LY,Wang J,Yin XY,Li L,Zheng L

Sun Aug 01 00:00:00 EDT 2010

The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.

Journal of immunology (Baltimore, Md. : 1950)

Thacker SG,Berthier CC,Mattinzoli D,Rastaldi MP,Kretzler M,Kaplan MJ

Fri Oct 01 00:00:00 EDT 2010

Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1.

Journal of immunology (Baltimore, Md. : 1950)

Gosset M,Pigenet A,Salvat C,Berenbaum F,Jacques C

Mon Nov 15 00:00:00 EST 2010

RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter.

Journal of immunology (Baltimore, Md. : 1950)

Burgler S,Mantel PY,Bassin C,Ouaked N,Akdis CA,Schmidt-Weber CB

Tue Jun 01 00:00:00 EDT 2010

IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.

Journal of immunology (Baltimore, Md. : 1950)

Ho AW,Shen F,Conti HR,Patel N,Childs EE,Peterson AC,Hernández-Santos N,Kolls JK,Kane LP,Ouyang W,Gaffen SL

Thu Jul 15 00:00:00 EDT 2010

IL-17 immunity in human type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950)

Honkanen J,Nieminen JK,Gao R,Luopajarvi K,Salo HM,Ilonen J,Knip M,Otonkoski T,Vaarala O

Sun Aug 01 00:00:00 EDT 2010

The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B.

Journal of immunology (Baltimore, Md. : 1950)

Privratsky JR,Tourdot BE,Newman DK,Newman PJ

Mon Mar 15 00:00:00 EDT 2010

Short-time survival and engraftment of bone marrow stromal cells in an ectopic model of bone regeneration.

Tissue engineering. Part A

Giannoni P,Scaglione S,Daga A,Ilengo C,Cilli M,Quarto R

Mon Feb 01 00:00:00 EST 2010

Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.

BMC immunology

Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø

Fri Jul 09 00:00:00 EDT 2010

Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.

The Journal of biological chemistry

Humphrey RK,Newcomb CJ,Yu SM,Hao E,Yu D,Krajewski S,Du K,Jhala US

Fri Jul 16 00:00:00 EDT 2010

Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.

The Journal of biological chemistry

Roell MK,Issafras H,Bauer RJ,Michelson KS,Mendoza N,Vanegas SI,Gross LM,Larsen PD,Bedinger DH,Bohmann DJ,Nonet GH,Liu N,Lee SR,Handa M,Kantak SS,Horwitz AH,Hunter JJ,Owyang AM,Mirza AM,Corbin JA,White ML

Fri Jul 02 00:00:00 EDT 2010

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.

The Journal of biological chemistry

Sayama K,Yamamoto M,Shirakata Y,Hanakawa Y,Hirakawa S,Dai X,Tohyama M,Tokumaru S,Shin MS,Sakurai H,Akira S,Hashimoto K

Fri Sep 24 00:00:00 EDT 2010

Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway.

The Journal of biological chemistry

Vigetti D,Genasetti A,Karousou E,Viola M,Moretto P,Clerici M,Deleonibus S,De Luca G,Hascall VC,Passi A

Fri Aug 06 00:00:00 EDT 2010

Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.

Molecular pain

Chen T,Koga K,Li XY,Zhuo M

Fri Apr 09 00:00:00 EDT 2010

Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo.

PloS one

Azcutia V,Abu-Taha M,Romacho T,Vázquez-Bella M,Matesanz N,Luscinskas FW,Rodríguez-Mañas L,Sanz MJ,Sánchez-Ferrer CF,Peiró C

Thu Apr 08 00:00:00 EDT 2010

Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion.

PloS one

Ombetta JE,Thelier N,Dong CZ,Plocki S,Tsagris L,Rannou F,Massicot F,Djimdé A,El-Hayek E,Shi Y,Heymans F,Gresh N,Chauvet C

Tue Jun 01 00:00:00 EDT 2010

Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity.

Journal of inflammation (London, England)

Jensen SS,Gad M

Tue Jul 27 00:00:00 EDT 2010

Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum.

PloS one

Curnow SJ,Fairclough M,Schmutz C,Kissane S,Denniston AK,Nash K,Buckley CD,Lord JM,Salmon M

Thu Mar 18 00:00:00 EDT 2010

Defining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate.

PloS one

Dibble CF,Horst JA,Malone MH,Park K,Temple B,Cheeseman H,Barbaro JR,Johnson GL,Bencharit S

Fri Jul 23 00:00:00 EDT 2010

Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses.

The Journal of biological chemistry

Thoh M,Kumar P,Nagarajaram HA,Manna SK

Fri Feb 19 00:00:00 EST 2010

Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.

Molecular cancer

Valentine R,Dawson CW,Hu C,Shah KM,Owen TJ,Date KL,Maia SP,Shao J,Arrand JR,Young LS,O'Neil JD

Tue Jan 05 00:00:00 EST 2010

Cleavage of the NF-κB family protein p65/RelA by the chlamydial protease-like activity factor (CPAF) impairs proinflammatory signaling in cells infected with Chlamydiae.

The Journal of biological chemistry

Christian J,Vier J,Paschen SA,Häcker G

Fri Dec 31 00:00:00 EST 2010

PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.

The Journal of biological chemistry

Nakamura K,Kimple AJ,Siderovski DP,Johnson GL

Fri Jan 15 00:00:00 EST 2010

High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression.

PloS one

Fred RG,Bang-Berthelsen CH,Mandrup-Poulsen T,Grunnet LG,Welsh N

Wed May 26 00:00:00 EDT 2010

AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.

The Journal of biological chemistry

Meares GP,Hughes KJ,Jaimes KF,Salvatori AS,Rhodes CJ,Corbett JA

Fri Jan 29 00:00:00 EST 2010

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.

Nature

Trompette A,Divanovic S,Visintin A,Blanchard C,Hegde RS,Madan R,Thorne PS,Wills-Karp M,Gioannini TL,Weiss JP,Karp CL

Thu Jan 29 00:00:00 EST 2009

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.

Immunity

Chung Y,Chang SH,Martinez GJ,Yang XO,Nurieva R,Kang HS,Ma L,Watowich SS,Jetten AM,Tian Q,Dong C

Fri Apr 17 00:00:00 EDT 2009

Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.

Blood

Pecaric-Petkovic T,Didichenko SA,Kaempfer S,Spiegl N,Dahinden CA

Thu Feb 12 00:00:00 EST 2009

Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome.

The Journal of experimental medicine

Minegishi Y,Saito M,Nagasawa M,Takada H,Hara T,Tsuchiya S,Agematsu K,Yamada M,Kawamura N,Ariga T,Tsuge I,Karasuyama H

Mon Jun 08 00:00:00 EDT 2009

Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation.

The Journal of experimental medicine

Haniffa M,Ginhoux F,Wang XN,Bigley V,Abel M,Dimmick I,Bullock S,Grisotto M,Booth T,Taub P,Hilkens C,Merad M,Collin M

Mon Feb 16 00:00:00 EST 2009

Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research

Tsukamoto N,Okada S,Onami Y,Sasaki Y,Umezawa K,Kawakami Y

Tue Sep 15 00:00:00 EDT 2009

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals.

Proceedings of the National Academy of Sciences of the United States of America

Bazzoni F,Rossato M,Fabbri M,Gaudiosi D,Mirolo M,Mori L,Tamassia N,Mantovani A,Cassatella MA,Locati M

Tue Mar 31 00:00:00 EDT 2009

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.

Proceedings of the National Academy of Sciences of the United States of America

Lu T,Jackson MW,Singhi AD,Kandel ES,Yang M,Zhang Y,Gudkov AV,Stark GR

Tue Sep 22 00:00:00 EDT 2009

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown.

Proceedings of the National Academy of Sciences of the United States of America

Argaw AT,Gurfein BT,Zhang Y,Zameer A,John GR

Tue Feb 10 00:00:00 EST 2009

Regulation of pentraxin-3 by antioxidants.

British journal of anaesthesia

Hill AL,Lowes DA,Webster NR,Sheth CC,Gow NA,Galley HF

Tue Dec 01 00:00:00 EST 2009

Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing.

The Journal of cell biology

Chong HC,Tan MJ,Philippe V,Tan SH,Tan CK,Ku CW,Goh YY,Wahli W,Michalik L,Tan NS

Mon Mar 23 00:00:00 EDT 2009

Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin.

PLoS pathogens

Bachman MA,Miller VL,Weiser JN

Thu Oct 01 00:00:00 EDT 2009

A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.

PLoS pathogens

Eberl M,Roberts GW,Meuter S,Williams JD,Topley N,Moser B

Sun Feb 01 00:00:00 EST 2009

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

Immunology and cell biology

Ma CS,Suryani S,Avery DT,Chan A,Nanan R,Santner-Nanan B,Deenick EK,Tangye SG

Thu Jan 14 00:00:00 EST 2010

In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage.

Arthritis research & therapy

Pretzel D,Pohlers D,Weinert S,Kinne RW

Wed Sep 09 00:00:00 EDT 2009

Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H

Wed Jul 01 00:00:00 EDT 2009

MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells.

Journal of immunology (Baltimore, Md. : 1950)

Qu C,Nguyen VA,Merad M,Randolph GJ

Sun Mar 15 00:00:00 EDT 2009

Developmental switch of the expression of ion channels in human dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Zsiros E,Kis-Toth K,Hajdu P,Gaspar R,Bielanska J,Felipe A,Rajnavolgyi E,Panyi G

Thu Oct 01 00:00:00 EDT 2009

1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Széles L,Keresztes G,Töröcsik D,Balajthy Z,Krenács L,Póliska S,Steinmeyer A,Zuegel U,Pruenster M,Rot A,Nagy L

Sun Feb 15 00:00:00 EST 2009

A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

Journal of immunology (Baltimore, Md. : 1950)

Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N

Wed Jul 01 00:00:00 EDT 2009

Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

Journal of immunology (Baltimore, Md. : 1950)

Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B

Sat Aug 01 00:00:00 EDT 2009

IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke.

Journal of immunology (Baltimore, Md. : 1950)

Chen WY,Chang MS

Wed Apr 15 00:00:00 EDT 2009

IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke.

Journal of immunology (Baltimore, Md. : 1950)

Chen WY,Chang MS

Wed Apr 15 00:00:00 EDT 2009

Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.

Journal of immunology (Baltimore, Md. : 1950)

Kishuku M,Nishioka Y,Abe S,Kishi J,Ogino H,Aono Y,Azuma M,Kinoshita K,Batmunkh R,Makino H,Ranjan P,Minakuchi K,Sone S

Tue Dec 15 00:00:00 EST 2009

Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.

Journal of neurotrauma

Helmy A,Carpenter KL,Skepper JN,Kirkpatrick PJ,Pickard JD,Hutchinson PJ

Wed Apr 01 00:00:00 EDT 2009

Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression.

The Journal of biological chemistry

Hughes KJ,Meares GP,Chambers KT,Corbett JA

Fri Oct 02 00:00:00 EDT 2009

Modulation of hyaluronan synthase activity in cellular membrane fractions.

The Journal of biological chemistry

Vigetti D,Genasetti A,Karousou E,Viola M,Clerici M,Bartolini B,Moretto P,De Luca G,Hascall VC,Passi A

Fri Oct 30 00:00:00 EDT 2009

Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways.

PloS one

St-Onge M,Dumas A,Michaud A,Laflamme C,Dussault AA,Pouliot M

Thu May 14 00:00:00 EDT 2009

Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling.

The Journal of biological chemistry

Nold-Petry CA,Nold MF,Nielsen JW,Bustamante A,Zepp JA,Storm KA,Hong JW,Kim SH,Dinarello CA

Fri Sep 18 00:00:00 EDT 2009

Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.

Blood

Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA

Sat Nov 01 00:00:00 EDT 2008

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3.

The Journal of experimental medicine

Ma CS,Chew GY,Simpson N,Priyadarshi A,Wong M,Grimbacher B,Fulcher DA,Tangye SG,Cook MC

Mon Jul 07 00:00:00 EDT 2008

Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America

Miyahara Y,Odunsi K,Chen W,Peng G,Matsuzaki J,Wang RF

Tue Oct 07 00:00:00 EDT 2008

Inhibition of IkappaB kinase by vaccinia virus virulence factor B14.

PLoS pathogens

Chen RA,Ryzhakov G,Cooray S,Randow F,Smith GL

Fri Feb 08 00:00:00 EST 2008

A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.

Journal of immunology (Baltimore, Md. : 1950)

Parker LC,Prestwich EC,Ward JR,Smythe E,Berry A,Triantafilou M,Triantafilou K,Sabroe I

Wed Oct 15 00:00:00 EDT 2008

Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.

Journal of immunology (Baltimore, Md. : 1950)

Hartl D,Krauss-Etschmann S,Koller B,Hordijk PL,Kuijpers TW,Hoffmann F,Hector A,Eber E,Marcos V,Bittmann I,Eickelberg O,Griese M,Roos D

Mon Dec 01 00:00:00 EST 2008

Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor.

Journal of immunology (Baltimore, Md. : 1950)

Attur M,Al-Mussawir HE,Patel J,Kitay A,Dave M,Palmer G,Pillinger MH,Abramson SB

Wed Oct 01 00:00:00 EDT 2008

Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii.

Journal of immunology (Baltimore, Md. : 1950)

Aronoff DM,Hao Y,Chung J,Coleman N,Lewis C,Peres CM,Serezani CH,Chen GH,Flamand N,Brock TG,Peters-Golden M

Sun Jun 15 00:00:00 EDT 2008

Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress.

Journal of immunology (Baltimore, Md. : 1950)

Ando T,Mimura K,Johansson CC,Hanson MG,Mougiakakos D,Larsson C,Martins da Palma T,Sakurai D,Norell H,Li M,Nishimura MI,Kiessling R

Mon Dec 15 00:00:00 EST 2008

B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.

Journal of immunology (Baltimore, Md. : 1950)

Takagi R,Higashi T,Hashimoto K,Nakano K,Mizuno Y,Okazaki Y,Matsushita S

Tue Jul 01 00:00:00 EDT 2008

Leptin inhibits food-deprivation-induced increases in food intake and food hoarding.

American journal of physiology. Regulatory, integrative and comparative physiology

Keen-Rhinehart E,Bartness TJ

Mon Dec 01 00:00:00 EST 2008

Interferon-alpha controls IL-17 expression in vitro and in vivo.

Immunobiology

Moschen AR,Geiger S,Krehan I,Kaser A,Tilg H

Thu Feb 05 00:00:00 EST 2009

Dose dependent effects of platelet derived chondroitinsulfate A on the binding of CCL5 to endothelial cells.

BMC immunology

Weingart C,Nelson PJ,Krämer BK,Mack M

Wed Dec 10 00:00:00 EST 2008

Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors.

BMC immunology

Moldenhauer A,Genter G,Lun A,Bal G,Kiesewetter H,Salama A

Wed Oct 01 00:00:00 EDT 2008

Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.

BMC immunology

Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD

Thu Aug 07 00:00:00 EDT 2008

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.

Blood

Munitz A,Bachelet I,Eliashar R,Moretta A,Moretta L,Levi-Schaffer F

Wed Mar 01 00:00:00 EST 2006

SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.

The Journal of clinical investigation

Wong PK,Egan PJ,Croker BA,O'Donnell K,Sims NA,Drake S,Kiu H,McManus EJ,Alexander WS,Roberts AW,Wicks IP

Thu Jun 01 00:00:00 EDT 2006

CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Cappello P,Fraone T,Barberis L,Costa C,Hirsch E,Elia AR,Caorsi C,Musso T,Novelli F,Giovarelli M

Wed Nov 01 00:00:00 EST 2006

Differential pattern of inflammatory molecule regulation in intestinal epithelial cells stimulated with IL-1.

Journal of immunology (Baltimore, Md. : 1950)

Yan SR,Joseph RR,Wang J,Stadnyk AW

Sun Oct 15 00:00:00 EDT 2006

Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.

Journal of immunology (Baltimore, Md. : 1950)

Eksteen B,Miles A,Curbishley SM,Tselepis C,Grant AJ,Walker LS,Adams DH

Sat Jul 01 00:00:00 EDT 2006

IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cells.

Journal of immunology (Baltimore, Md. : 1950)

Schaefer TM,Wright JA,Pioli PA,Wira CR

Tue Nov 15 00:00:00 EST 2005

Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol.

Journal of immunology (Baltimore, Md. : 1950)

Øynebråten I,Barois N,Hagelsteen K,Johansen FE,Bakke O,Haraldsen G

Sat Oct 15 00:00:00 EDT 2005

Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines.

Circulation

Nabah YN,Mateo T,Estellés R,Mata M,Zagorski J,Sarau H,Cortijo J,Morcillo EJ,Jose PJ,Sanz MJ

Tue Dec 07 00:00:00 EST 2004

Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form.

Blood

Sahni A,Guo M,Sahni SK,Francis CW

Thu Jul 15 00:00:00 EDT 2004

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

Cancer research

Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT

Sat Feb 15 00:00:00 EST 2003

IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.

Journal of immunology (Baltimore, Md. : 1950)

Maertzdorf J,Osterhaus AD,Verjans GM

Fri Nov 15 00:00:00 EST 2002

IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses.

Journal of immunology (Baltimore, Md. : 1950)

Olee T,Hashimoto S,Quach J,Lotz M

Fri Jan 15 00:00:00 EST 1999

Bioinformatics

Protein Aliases: Catabolin; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1β; IL-1 beta; IL1 B; IL1β; ILN; Interleukin; Interleukin 1 beta precursor; interleukin 1, beta; Interleukin-1 beta; Interleukin-1b; Interleukin1 beta; LAF; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; pro-interleukin-1-beta

Human IL-1 beta Recombinant Protein, PeproTech®

Human IL-1 beta Protein (200-01B-10UG) in Functional

Product Details

200-01B-10UG

Western Blot (WB)

Flow Cytometry (Flow)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

We're here to help

Your items have has been added!