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Product Details
200-12RB-2-100UG
Product Specifications
Species
Human
Expression System
CHO cells
Amino acid sequence
CKRGDVTVKP SHVILLGSTV NITCSLKPRQ GCFHYSRRNK LILYKFDRRI NFHHGHSLNS QVTGLPLGTT LFVCKLACIN SDEIQICGAE IFVGVAPEQP QNLSCIQKGE QGTVACTWER GRDTHLYTEY TLQLSGPKNL TWQKQCKDIY CDYLDFGINL TPESPESNFT AKVTAVNSLG SSSSLPSTFT FLDIVRPLPP WDIRIKFQKA SVSRCTLYWR DEGLVLLNRL RYRPSNSRLW NMVNVTKAKG RHDLLDLKPF TEYEFQISSK LHLYKGSWSD WSESLRAQTP EEEPTGMLDV WYMKRHIDYS RQQISLFWKN LSVSEARGKI LHYQVTLQEL TGGKAMTQNI TGHTSWTTVI PRTGNWAVAV SAANSKGSSL PTRINIMNLC EAGLLAPRQV SANSEGMDNI LVTWQPPRKD PSAVQEYVVE WRELHPGGDT QVPLNWLRSR PYNVSALISE NIKSYICYEI RVYALSGDQG GCSSILGNSK HKAPLSGPHI NAITEEKGSI LISWNSIPVQ EQMGCLLHYR IYWKERDSNS QPQLCEIPYR VSQNSHPINS LQPRVTYVLW MTALTAAGES SHGNEREFCL QGKANGGPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHHHH
Tag
Fc-tag, His-tag
Molecular weight
94.9 kDa
Class
Recombinant
Type
Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Human sIL-2 Receptor beta-2 Fc activity is measured by its ability to bind to Human IL-12p70 in a functional ELISA.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Human sIL-12 Receptor beta-2 Fc has a calculated molecular weight of 94.9 kDa, and contains 839 amino acid residues, which consists of the extracellular domain of IL-12R beta-2 fused to the Fc portion of human IgG and contains a C-terminal His-tag. Due to glycosylation, it migrates at an approximate molecular weight of 116 kDa, under reducing conditions.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain; Interleukin-12 receptor subunit beta-2; RP11-102M16.1
Gene Aliases: IL12RB2
UniProt ID: (Human) Q99665
Entrez Gene ID: (Human) 3595
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