Gibco

Human IL-12 p80 Recombinant Protein, PeproTech®

Product Details

200-12P80H-10UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 11 publications 11 publications

Product Specifications

Species

Human

Published species

Human

Expression System

Insect cells

Amino acid sequence

p40 subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS

Molecular weight

80 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

200-12P80H-1MG will be provided as 10 x 100 µg (200-12P80H-100UG).

200-12P80H-250UG will be provided as multiple 50 µg (200-12P80H-50UG) and 100 µg (200-12P80H-100UG) vials.

200-12P80H-500UG will be provided as 5 x 100 µg (200-12P80H-100UG).

Recombinant Human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Unique immunological profile in patients with COVID-19.

Cellular & molecular immunology

Varchetta S,Mele D,Oliviero B,Mantovani S,Ludovisi S,Cerino A,Bruno R,Castelli A,Mosconi M,Vecchia M,Roda S,Sachs M,Klersy C,Mondelli MU

Mon Mar 01 00:00:00 EST 2021

Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells.

Cell

Collins PL,Cella M,Porter SI,Li S,Gurewitz GL,Hong HS,Johnson RP,Oltz EM,Colonna M

Thu Jan 10 00:00:00 EST 2019

NK cells are activated and primed for skin-homing during acute dengue virus infection in humans.

Nature communications

Zimmer CL,Cornillet M,Solà-Riera C,Cheung KW,Ivarsson MA,Lim MQ,Marquardt N,Leo YS,Lye DC,Klingström J,MacAry PA,Ljunggren HG,Rivino L,Björkström NK

Thu Aug 29 00:00:00 EDT 2019

Soy isoflavones and their metabolites modulate cytokine-induced natural killer cell function.

Scientific reports

Mace TA,Ware MB,King SA,Loftus S,Farren MR,McMichael E,Scoville S,Geraghty C,Young G,Carson WE,Clinton SK,Lesinski GB

Mon Mar 25 00:00:00 EDT 2019

The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.

PloS one

Qi Y,Operario DJ,Georas SN,Mosmann TR

Thu Dec 13 00:00:00 EST 2012

Networked T cell death following macrophage infection by Mycobacterium tuberculosis.

PloS one

Macdonald SH,Woodward E,Coleman MM,Dorris ER,Nadarajan P,Chew WM,McLaughlin AM,Keane J

Thu Oct 11 00:00:00 EDT 2012

Characterization of T-cell responses against IκBα in cancer patients.

Oncoimmunology

Munir S,Frøsig TM,Hansen M,Svane IM,Andersen MH

Thu Nov 01 00:00:00 EDT 2012

Human natural killer cell maturation defect supports in vivo CD56(bright) to CD56(dim) lineage development.

PloS one

Domaica CI,Fuertes MB,Uriarte I,Girart MV,Sardañons J,Comas DI,Di Giovanni D,Gaillard MI,Bezrodnik L,Zwirner NW

Thu May 30 00:00:00 EDT 2013

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.

Oncoimmunology

Mandapathil M,Szczepanski M,Harasymczuk M,Ren J,Cheng D,Jackson EK,Gorelik E,Johnson J,Lang S,Whiteside TL

Wed Aug 01 00:00:00 EDT 2012

Severe impairment of IFN-γ and IFN-α responses in cells of a patient with a novel STAT1 splicing mutation.

Blood

Vairo D,Tassone L,Tabellini G,Tamassia N,Gasperini S,Bazzoni F,Plebani A,Porta F,Notarangelo LD,Parolini S,Giliani S,Badolato R

Thu Aug 18 00:00:00 EDT 2011

Plasmodium falciparum-infected erythrocytes and IL-12/IL-18 induce diverse transcriptomes in human NK cells: IFN-α/β pathway versus TREM signaling.

PloS one

Grangeiro de Carvalho E,Bonin M,Kremsner PG,Kun JF

Fri Feb 03 00:00:00 EST 2012

Bioinformatics

Protein Aliases: CLMF p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12; IL-12 subunit p40; IL-12B; IL12, subunit p40; interleukin 12, p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; Interleukin-12 subunit beta; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF2

Human IL-12 p80 Recombinant Protein, PeproTech®

Product Details

200-12P80H-10UG

Functional Assay (Functional)

In vitro Assay (IV)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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