Gibco

Human IL-15 Recombinant Protein, PeproTech®

Human IL-15 Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Human IL-15 Protein (200-15-10UG) in Functional

Bioassay analysis of Human IL-15 Recombinant Protein, PeproTech® (Product # 200-15-1MG).

Product Image Gallery

Product Details

200-15-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

View 2 publications 2 publications

Neutralization (Neu)

View 1 publication 1 publication

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 323 publications 323 publications

Miscellaneous PubMed (Misc)

View 22 publications 22 publications

Immunostaining (IS)

View 1 publication 1 publication

Product Specifications

Species

Human

Published species

Dog, Hamster, Human, Mouse, Non-human primate, Virus

Expression System

E. coli

Amino acid sequence

MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

Molecular weight

12.9 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10^6 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.

British journal of haematology

Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y

200-15 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.

Sat Jul 01 00:00:00 EDT 2023

EGFR as a potent CAR T target in triple negative breast cancer brain metastases.

Breast cancer research and treatment

Subham S,Jeppson JD,Worcester C,Schatmeyer B,Zhao J,Madan R,Lakis NS,Kimler BF,McGuirk JP,Chen RC,Stecklein SR,Akhavan D

200-15 was used in Cell Culture to demonstrate anti-tumor activity of EGFR806 CAR T cells against TNBC cells in vitro and in vivo.

Sun Jan 01 00:00:00 EST 2023

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins.

Cell

Banskota S,Raguram A,Suh S,Du SW,Davis JR,Choi EH,Wang X,Nielsen SC,Newby GA,Randolph PB,Osborn MJ,Musunuru K,Palczewski K,Liu DR

Thu Jan 20 00:00:00 EST 2022

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4⁺ T cells allows complex functional analyses.

Nature methods

Albanese M,Ruhle A,Mittermaier J,Mejías-Pérez E,Gapp M,Linder A,Schmacke NA,Hofmann K,Hennrich AA,Levy DN,Humpe A,Conzelmann KK,Hornung V,Fackler OT,Keppler OT

Sat Jan 01 00:00:00 EST 2022

Disease-associated mutations in topoisomerase IIβ result in defective NK cells.

The Journal of allergy and clinical immunology

Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS

200-15 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.

Wed Jun 01 00:00:00 EDT 2022

Epigenetic state determines inflammatory sensing in neuroblastoma.

Proceedings of the National Academy of Sciences of the United States of America

Wolpaw AJ,Grossmann LD,Dessau JL,Dong MM,Aaron BJ,Brafford PA,Volgina D,Pascual-Pasto G,Rodriguez-Garcia A,Uzun Y,Arsenian-Henriksson M,Powell DJ,Bosse KR,Kossenkov A,Tan K,Hogarty MD,Maris JM,Dang CV

200-15 was used in In vitro experiments to investigate inflammatory signaling pathways in neuroblastoma which was found to rely on epigentic state of the tumor.

Tue Feb 08 00:00:00 EST 2022

Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.

EMBO reports

Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB

200-15 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.

Thu Feb 03 00:00:00 EST 2022

LINC00152 expression in normal and Chronic Lymphocytic Leukemia B cells.

Hematological oncology

Matis S,Rossi M,Brondolo L,Cardillo M,Reverberi D,Massara R,Colombo M,Ibatici A,Angelucci E,Vaisitti T,Bruno S,Fabris S,Neri A,Gentile M,Morabito F,Cutrona G,Briata P,Gherzi R,Fais F

Tue Feb 01 00:00:00 EST 2022

JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.

JCI insight

Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA

200-15 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.

Wed Jun 08 00:00:00 EDT 2022

Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair.

STAR protocols

Moosmann C,Müller TR,Busch DH,Schober K

Fri Mar 18 00:00:00 EDT 2022

IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.

Cell reports

Dudek M,Lohr K,Donakonda S,Baumann T,Lüdemann M,Hegenbarth S,Dübbel L,Eberhagen C,Michailidou S,Yassin A,Prinz M,Popper B,Rose-John S,Zischka H,Knolle PA

200-15 was used in In vitro experiments to report that high-level mitochondrial respiration and constitutive low-level glycolysis support LSEC scavenger and sentinel functions.

Tue Feb 15 00:00:00 EST 2022

CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells.

Nature communications

Hebbar N,Epperly R,Vaidya A,Thanekar U,Moore SE,Umeda M,Ma J,Patil SL,Langfitt D,Huang S,Cheng C,Klco JM,Gottschalk S,Velasquez MP

Mon Jan 31 00:00:00 EST 2022

Functional HPV-specific PD-1⁺ stem-like CD8 T cells in head and neck cancer.

Nature

Eberhardt CS,Kissick HT,Patel MR,Cardenas MA,Prokhnevska N,Obeng RC,Nasti TH,Griffith CC,Im SJ,Wang X,Shin DM,Carrington M,Chen ZG,Sidney J,Sette A,Saba NF,Wieland A,Ahmed R

Wed Sep 01 00:00:00 EDT 2021

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.

Nature

Witkowski M,Tizian C,Ferreira-Gomes M,Niemeyer D,Jones TC,Heinrich F,Frischbutter S,Angermair S,Hohnstein T,Mattiola I,Nawrath P,McEwen S,Zocche S,Viviano E,Heinz GA,Maurer M,Kölsch U,Chua RL,Aschman T,Meisel C,Radke J,Sawitzki B,Roehmel J,Allers K,Moos V,Schneider T,Hanitsch L,Mall MA,Conrad C,Radbruch H,Duerr CU,Trapani JA,Marcenaro E,Kallinich T,Corman VM,Kurth F,Sander LE,Drosten C,Treskatsch S,Durek P,Kruglov A,Radbruch A,Mashreghi MF,Diefenbach A

200-15 was used in Cell Culture to investigate if a decline in viral load in COVID-19 correlates with Natural killer (NK) cell status and if NK cells can control SARS-CoV-2 replication by recognizing infected target cells.

Wed Dec 01 00:00:00 EST 2021

Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH.

Nature

Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA

200-15 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.

Thu Apr 01 00:00:00 EDT 2021

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers.

Nature

Caushi JX,Zhang J,Ji Z,Vaghasia A,Zhang B,Hsiue EH,Mog BJ,Hou W,Justesen S,Blosser R,Tam A,Anagnostou V,Cottrell TR,Guo H,Chan HY,Singh D,Thapa S,Dykema AG,Burman P,Choudhury B,Aparicio L,Cheung LS,Lanis M,Belcaid Z,El Asmar M,Illei PB,Wang R,Meyers J,Schuebel K,Gupta A,Skaist A,Wheelan S,Naidoo J,Marrone KA,Brock M,Ha J,Bush EL,Park BJ,Bott M,Jones DR,Reuss JE,Velculescu VE,Chaft JE,Kinzler KW,Zhou S,Vogelstein B,Taube JM,Hellmann MD,Brahmer JR,Merghoub T,Forde PM,Yegnasubramanian S,Ji H,Pardoll DM,Smith KN

Sun Aug 01 00:00:00 EDT 2021

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Cell

Chen PJ,Hussmann JA,Yan J,Knipping F,Ravisankar P,Chen PF,Chen C,Nelson JW,Newby GA,Sahin M,Osborn MJ,Weissman JS,Adamson B,Liu DR

Thu Oct 28 00:00:00 EDT 2021

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults.

Immunity

Pan YG,Aiamkitsumrit B,Bartolo L,Wang Y,Lavery C,Marc A,Holec PV,Rappazzo CG,Eilola T,Gimotty PA,Hensley SE,Antia R,Zarnitsyna VI,Birnbaum ME,Su LF

200-15 was used in In vitro experiments to examine how baseline CD4+ T cell repertoire and precursor states impact responses to pathogen infection in humans using primary immunization with yellow fever virus vaccine.

Tue Jun 08 00:00:00 EDT 2021

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.

Immunity

Ehx G,Larouche JD,Durette C,Laverdure JP,Hesnard L,Vincent K,Hardy MP,Thériault C,Rulleau C,Lanoix J,Bonneil E,Feghaly A,Apavaloaei A,Noronha N,Laumont CM,Delisle JS,Vago L,Hébert J,Sauvageau G,Lemieux S,Thibault P,Perreault C

Tue Apr 13 00:00:00 EDT 2021

Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer.

Signal transduction and targeted therapy

Ding Z,Li Q,Zhang R,Xie L,Shu Y,Gao S,Wang P,Su X,Qin Y,Wang Y,Fang J,Zhu Z,Xia X,Wei G,Wang H,Qian H,Guo X,Gao Z,Wang Y,Wei Y,Xu Q,Xu H,Yang L

Wed Jan 20 00:00:00 EST 2021

Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.

Signal transduction and targeted therapy

Zheng G,Guo Z,Li W,Xi W,Zuo B,Zhang R,Wen W,Yang AG,Jia L

Wed Jun 23 00:00:00 EDT 2021

Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues.

Nature immunology

Friedrich C,Taggenbrock RLRE,Doucet-Ladevèze R,Golda G,Moenius R,Arampatzi P,Kragten NAM,Kreymborg K,Gomez de Agüero M,Kastenmüller W,Saliba AE,Grün D,van Gisbergen KPJM,Gasteiger G

Fri Oct 01 00:00:00 EDT 2021

Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR-T-cell responses against ALL.

Blood

Zheng W,Wei J,Zebley CC,Jones LL,Dhungana Y,Wang YD,Mavuluri J,Long L,Fan Y,Youngblood B,Chi H,Geiger TL

Thu Jul 15 00:00:00 EDT 2021

Human skin is colonized by T cells that recognize CD1a independently of lipid.

The Journal of clinical investigation

Cotton RN,Cheng TY,Wegrecki M,Le Nours J,Orgill DP,Pomahac B,Talbot SG,Willis RA,Altman JD,de Jong A,Ogg G,Van Rhijn I,Rossjohn J,Clark RA,Moody DB

Mon Jan 04 00:00:00 EST 2021

A therapeutic cancer vaccine delivers antigens and adjuvants to lymphoid tissues using genetically modified T cells.

The Journal of clinical investigation

Veatch JR,Singhi N,Srivastava S,Szeto JL,Jesernig B,Stull SM,Fitzgibbon M,Sarvothama M,Yechan-Gunja S,James SE,Riddell SR

Mon Aug 16 00:00:00 EDT 2021

CD1a selectively captures endogenous cellular lipids that broadly block T cell response.

The Journal of experimental medicine

Cotton RN,Wegrecki M,Cheng TY,Chen YL,Veerapen N,Le Nours J,Orgill DP,Pomahac B,Talbot SG,Willis R,Altman JD,de Jong A,Van Rhijn I,Clark RA,Besra GS,Ogg G,Rossjohn J,Moody DB

Mon Jul 05 00:00:00 EDT 2021

αβγδ T cells play a vital role in fetal human skin development and immunity.

The Journal of experimental medicine

Reitermaier R,Krausgruber T,Fortelny N,Ayub T,Vieyra-Garcia PA,Kienzl P,Wolf P,Scharrer A,Fiala C,Kölz M,Hiess M,Vierhapper M,Schuster C,Spittler A,Worda C,Weninger W,Bock C,Eppel W,Elbe-Bürger A

Mon Apr 05 00:00:00 EDT 2021

STING agonist promotes CAR T cell trafficking and persistence in breast cancer.

The Journal of experimental medicine

Xu N,Palmer DC,Robeson AC,Shou P,Bommiasamy H,Laurie SJ,Willis C,Dotti G,Vincent BG,Restifo NP,Serody JS

Mon Feb 01 00:00:00 EST 2021

The SIRPα-CD47 immune checkpoint in NK cells.

The Journal of experimental medicine

Deuse T,Hu X,Agbor-Enoh S,Jang MK,Alawi M,Saygi C,Gravina A,Tediashvili G,Nguyen VQ,Liu Y,Valantine H,Lanier LL,Schrepfer S

Mon Mar 01 00:00:00 EST 2021

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.

EMBO molecular medicine

Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P

Fri Mar 05 00:00:00 EST 2021

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.

Proceedings of the National Academy of Sciences of the United States of America

Clement M,Knezevic L,Dockree T,McLaren JE,Ladell K,Miners KL,Llewellyn-Lacey S,Rubina A,Francis O,Cole DK,Sewell AK,Bridgeman JS,Price DA,van den Berg HA,Wooldridge L

Tue Jul 20 00:00:00 EDT 2021

Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.

International journal of cancer

Herda S,Heimann A,Obermayer B,Ciraolo E,Althoff S,Ruß J,Grunert C,Busse A,Bullinger L,Pezzutto A,Blankenstein T,Beule D,Na IK

Tue Jun 15 00:00:00 EDT 2021

Cutting Edge: mTORC1 Inhibition in Metastatic Breast Cancer Patients Negatively Affects Peripheral NK Cell Maturation and Number.

Journal of immunology (Baltimore, Md. : 1950)

Besson L,Mery B,Morelle M,Rocca Y,Heudel PE,You B,Bachelot T,Ray-Coquard I,Villard M,Charrier E,Parant F,Viel S,Garin G,Mayet R,Perol D,Walzer T,Tredan O,Marçais A

Sat May 15 00:00:00 EDT 2021

Methylation-Sensitive Restriction Enzyme Quantitative Polymerase Chain Reaction Enables Rapid, Accurate, and Precise Detection of Methylation Status of the Regulatory T Cell (Treg)-Specific Demethylation Region in Primary Human Tregs.

Journal of immunology (Baltimore, Md. : 1950)

Perry N,Wasko K,Cheng J,Tabbaa D,Marco E,Giannoukos G,Albright CF,Borges CM

Fri Jan 15 00:00:00 EST 2021

CD29 Enriches for Cytotoxic Human CD4⁺ T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Nicolet BP,Guislain A,Wolkers MC

Wed Dec 15 00:00:00 EST 2021

GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma - assessing tumor and T cell interaction.

Translational oncology

Sujjitjoon J,Sayour E,Tsao ST,Uiprasertkul M,Sanpakit K,Buaboonnam J,Yenchitsomanus PT,Atchaneeyasakul LO,Chang LJ

Mon Feb 01 00:00:00 EST 2021

Peripheral leukemia burden at time of apheresis negatively affects the clinical efficacy of CART19 in refractory or relapsed B-ALL.

Molecular therapy. Methods & clinical development

Deng B,Pan J,Liu Z,Liu S,Chen Y,Qu X,Zhang Y,Lin Y,Zhang Y,Yu X,Zhang Z,Niu X,Luan R,Ma M,Li X,Liu T,Wu X,Niu H,Chang AH,Tong C

Fri Dec 10 00:00:00 EST 2021

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy.

Nature communications

Giuffrida L,Sek K,Henderson MA,Lai J,Chen AXY,Meyran D,Todd KL,Petley EV,Mardiana S,Mølck C,Stewart GD,Solomon BJ,Parish IA,Neeson PJ,Harrison SJ,Kats LM,House IG,Darcy PK,Beavis PA

Fri May 28 00:00:00 EDT 2021

Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors.

iScience

Portillo AL,Hogg R,Poznanski SM,Rojas EA,Cashell NJ,Hammill JA,Chew MV,Shenouda MM,Ritchie TM,Cao QT,Hirota JA,Dhesy-Thind S,Bramson JL,Ashkar AA

Fri Jun 25 00:00:00 EDT 2021

IL-15 enhances CCR5-mediated migration of memory CD8⁺ T cells by upregulating CCR5 expression in the absence of TCR stimulation.

Cell reports

Seo IH,Eun HS,Kim JK,Lee H,Jeong S,Choi SJ,Lee J,Lee BS,Kim SH,Rou WS,Lee DH,Kim W,Park SH,Shin EC

Tue Jul 27 00:00:00 EDT 2021

SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis.

Blood cancer journal

Maiti GP,Sinha S,Mahmud H,Boysen J,Mendez MT,Vesely SK,Holter-Chakrabarty J,Kay NE,Ghosh AK

Mon May 17 00:00:00 EDT 2021

Characteristics of Immune Memory and Effector Activity to Cancer-Expressed MHC Class I Phosphopeptides Differ in Healthy Donors and Ovarian Cancer Patients.

Cancer immunology research

Lulu AM,Cummings KL,Jeffery ED,Myers PT,Underwood D,Lacy RM,Chianese-Bullock KA,Slingluff CL,Modesitt SC,Engelhard VH

200-15 was used in In vitro experiments to suggest that the immunogens generating most phosphopeptide-specific immune memory are rare infectious agents or incipient cancer cells with distinct phosphoproteome dysregulations, and that repetitive immunogenic exposures occur in individual donors.

Mon Nov 01 00:00:00 EDT 2021

Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling.

Frontiers in immunology

Wurzer H,Filali L,Hoffmann C,Krecke M,Biolato AM,Mastio J,De Wilde S,François JH,Largeot A,Berchem G,Paggetti J,Moussay E,Thomas C

200-15 was used in Cell Culture to study the role of the chronic lymphocytic leukemia (CLL) cell actin cytoskeleton during natural killer (NK) cell attack to show CLL cells can undergo fast actin cytoskeleton remodeling which is characterized by a NK cell contact-induced accumulation of actin filaments at the immunological synapse (IS).

Mon Jun 28 00:00:00 EDT 2021

Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.

ImmunoHorizons

Malireddi RKS,Karki R,Sundaram B,Kancharana B,Lee S,Samir P,Kanneganti TD

200-15 was used in Cell Culture to investigate correlations between cytokine expression and mortality.

Wed Jul 21 00:00:00 EDT 2021

HLA-A^∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses.

Cell reports

Nesterenko PA,McLaughlin J,Tsai BL,Burton Sojo G,Cheng D,Zhao D,Mao Z,Bangayan NJ,Obusan MB,Su Y,Ng RH,Chour W,Xie J,Li YR,Lee D,Noguchi M,Carmona C,Phillips JW,Kim JT,Yang L,Heath JR,Boutros PC,Witte ON

Tue Dec 28 00:00:00 EST 2021

Directly reprogrammed natural killer cells for cancer immunotherapy.

Nature biomedical engineering

Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS

Mon Nov 01 00:00:00 EDT 2021

The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.

Communications biology

Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S

Mon Jun 07 00:00:00 EDT 2021

A single-chain antibody generation system yielding CAR-T cells with superior antitumor function.

Communications biology

Ochi T,Maruta M,Tanimoto K,Kondo F,Yamamoto T,Kurata M,Fujiwara H,Masumoto J,Takenaka K,Yasukawa M

Tue Mar 02 00:00:00 EST 2021

Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy.

Nature communications

Bent EH,Millán-Barea LR,Zhuang I,Goulet DR,Fröse J,Hemann MT

Thu Oct 28 00:00:00 EDT 2021

Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemics.

Scientific reports

Sivapalan R,Liu J,Chakraborty K,Arthofer E,Choudhry M,Barie PS,Barouch DH,Henley T

Tue Jul 27 00:00:00 EDT 2021

Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques.

Molecular therapy. Methods & clinical development

Haeseleer F,Fukazawa Y,Park H,Varco-Merth B,Rust BJ,Smedley JV,Eichholz K,Peterson CW,Mason R,Kiem HP,Roederer M,Picker LJ,Okoye AA,Corey L

Fri Sep 10 00:00:00 EDT 2021

Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples.

Molecular & cellular proteomics : MCP

Klaeger S,Apffel A,Clauser KR,Sarkizova S,Oliveira G,Rachimi S,Le PM,Tarren A,Chea V,Abelin JG,Braun DA,Ott PA,Keshishian H,Hacohen N,Keskin DB,Wu CJ,Carr SA

Thu Mar 24 00:00:00 EDT 2022

STAT3 governs the HIF-1α response in IL-15 primed human NK cells.

Scientific reports

Coulibaly A,Velásquez SY,Kassner N,Schulte J,Barbarossa MV,Lindner HA

Mon Mar 29 00:00:00 EDT 2021

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.

Cell reports

Zebley CC,Abdelsamed HA,Ghoneim HE,Alli S,Brown C,Haydar D,Mi T,Harris T,McGargill MA,Krenciute G,Youngblood B

Tue Oct 12 00:00:00 EDT 2021

NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions.

Cell reports

Cazzetta V,Bruni E,Terzoli S,Carenza C,Franzese S,Piazza R,Marzano P,Donadon M,Torzilli G,Cimino M,Simonelli M,Bello L,Villa A,Tan L,Ravens S,Prinz I,Supino D,Colombo FS,Lugli E,Marcenaro E,Vivier E,Della Bella S,Mikulak J,Mavilio D

Tue Oct 19 00:00:00 EDT 2021

Activated Lymphocytes and Increased Risk of Dermatologic Adverse Events during Sorafenib Therapy for Hepatocellular Carcinoma.

Cancers

Corominas J,Sapena V,Sanduzzi-Zamparelli M,Millán C,Samper E,Llarch N,Iserte G,Torres F,Da Fonseca LG,Muñoz-Martínez S,Forner A,Bruix J,Boix L,Reig M

200-15 was used in In vitro experiments to investigate immune implication accompanying better prognosis and dermatological adverse effects of sorafenib treatment of advanced hepatocellular carcinoma.

Sat Jan 23 00:00:00 EST 2021

SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells.

Nature communications

Jung JH,Rha MS,Sa M,Choi HK,Jeon JH,Seok H,Park DW,Park SH,Jeong HW,Choi WS,Shin EC

Wed Jun 30 00:00:00 EDT 2021

Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer.

STAR protocols

Rotolo A,Atherton MJ,Kasper BT,Haran KP,Mason NJ

200-15 was used in In vitro experiments to optimize a retrovirus-based protocol to efficiently CAR transduce primary T cells from healthy and tumor-bearing dogs.

Fri Dec 17 00:00:00 EST 2021

Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.

Cell reports. Medicine

Müller TR,Jarosch S,Hammel M,Leube J,Grassmann S,Bernard B,Effenberger M,Andrä I,Chaudhry MZ,Käuferle T,Malo A,Cicin-Sain L,Steinberger P,Feuchtinger T,Protzer U,Schumann K,Neuenhahn M,Schober K,Busch DH

Tue Aug 17 00:00:00 EDT 2021

Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint.

Nature communications

Schmidt NM,Wing PAC,Diniz MO,Pallett LJ,Swadling L,Harris JM,Burton AR,Jeffery-Smith A,Zakeri N,Amin OE,Kucykowicz S,Heemskerk MH,Davidson B,Meyer T,Grove J,Stauss HJ,Pineda-Torra I,Jolly C,Jury EC,McKeating JA,Maini MK

Fri May 14 00:00:00 EDT 2021

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.

Cell reports. Medicine

Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L

200-15 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.

Tue Nov 16 00:00:00 EST 2021

EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8⁺ T Cells.

Frontiers in immunology

Stairiker CJ,Pfister SX,Hendrickson E,Yang W,Xie T,Lee C,Zhang H,Dillon C,Thomas GD,Salek-Ardakani S

200-15 was used in In vitro experiments to support the requirement of EZH2 function in 4-1BB-mediated CD8+ T cell expansion and effector programming and emphasize the consideration that must be given when combining such antitumoral therapies.

Mon Feb 14 00:00:00 EST 2022

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.

Nature biomedical engineering

Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S

Mon Nov 01 00:00:00 EDT 2021

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.

Nature biomedical engineering

Mon Nov 01 00:00:00 EDT 2021

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity.

Cell reports

Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA,Hitosugi T,Bernlohr DA,Sun J,Zeng H

Tue Jan 05 00:00:00 EST 2021

Dual Targeting CAR-T Cells with Optimal Costimulation and Metabolic Fitness enhance Antitumor Activity and Prevent Escape in Solid Tumors.

Nature cancer

Hirabayashi K,Du H,Xu Y,Shou P,Zhou X,Fucá G,Landoni E,Sun C,Chen Y,Savoldo B,Dotti G

Wed Sep 01 00:00:00 EDT 2021

Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade.

Molecular therapy. Methods & clinical development

Awad RM,Lecocq Q,Zeven K,Ertveldt T,De Beck L,Ceuppens H,Broos K,De Vlaeminck Y,Goyvaerts C,Verdonck M,Raes G,Van Parys A,Cauwels A,Keyaerts M,Devoogdt N,Breckpot K

Fri Sep 10 00:00:00 EDT 2021

B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells.

bioRxiv : the preprint server for biology

Yu B,Qi Y,Li R,Shi Q,Satpathy A,Chang HY

Tue Jan 05 00:00:00 EST 2021

Tissue Determinants of Human NK Cell Development, Function, and Residence.

Cell

Dogra P,Rancan C,Ma W,Toth M,Senda T,Carpenter DJ,Kubota M,Matsumoto R,Thapa P,Szabo PA,Li Poon MM,Li J,Arakawa-Hoyt J,Shen Y,Fong L,Lanier LL,Farber DL

Thu Feb 20 00:00:00 EST 2020

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.

Cell

Ruscetti M,Morris JP,Mezzadra R,Russell J,Leibold J,Romesser PB,Simon J,Kulick A,Ho YJ,Fennell M,Li J,Norgard RJ,Wilkinson JE,Alonso-Curbelo D,Sridharan R,Heller DA,de Stanchina E,Stanger BZ,Sherr CJ,Lowe SW

200-15 was used in Cell Culture to show that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling can suppress PDAC proliferation through induction of retinoblastoma (RB) protein-mediated senescence.

Thu Apr 16 00:00:00 EDT 2020

Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development.

Immunity

Le J,Park JE,Ha VL,Luong A,Branciamore S,Rodin AS,Gogoshin G,Li F,Loh YE,Camacho V,Patel SB,Welner RS,Parekh C

Tue Jun 16 00:00:00 EDT 2020

THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells.

Cancer cell

Sun C,Shou P,Du H,Hirabayashi K,Chen Y,Herring LE,Ahn S,Xu Y,Suzuki K,Li G,Tsahouridis O,Su L,Savoldo B,Dotti G

Mon Feb 10 00:00:00 EST 2020

Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates.

Blood

Rust BJ,Kean LS,Colonna L,Brandenstein KE,Poole NH,Obenza W,Enstrom MR,Maldini CR,Ellis GI,Fennessey CM,Huang ML,Keele BF,Jerome KR,Riley JL,Kiem HP,Peterson CW

Thu Oct 08 00:00:00 EDT 2020

Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment.

Blood

Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR

Thu Dec 24 00:00:00 EST 2020

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.

Blood

Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE

Thu Aug 06 00:00:00 EDT 2020

Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells.

The Journal of clinical investigation

Yang Y,Neo SY,Chen Z,Cui W,Chen Y,Guo M,Wang Y,Xu H,Kurzay A,Alici E,Holmgren L,Haglund F,Wang K,Lundqvist A

Thu Oct 01 00:00:00 EDT 2020

CARD8 inflammasome activation triggers pyroptosis in human T cells.

The EMBO journal

Linder A,Bauernfried S,Cheng Y,Albanese M,Jung C,Keppler OT,Hornung V

Thu Oct 01 00:00:00 EDT 2020

CD29 identifies IFN-γ-producing human CD8⁺ T cells with an increased cytotoxic potential.

Proceedings of the National Academy of Sciences of the United States of America

Nicolet BP,Guislain A,van Alphen FPJ,Gomez-Eerland R,Schumacher TNM,van den Biggelaar M,Wolkers MC

Tue Mar 24 00:00:00 EDT 2020

Trans-endocytosis of intact IL-15Rα-IL-15 complex from presenting cells into NK cells favors signaling for proliferation.

Proceedings of the National Academy of Sciences of the United States of America

Anton OM,Peterson ME,Hollander MJ,Dorward DW,Arora G,Traba J,Rajagopalan S,Snapp EL,Garcia KC,Waldmann TA,Long EO

Tue Jan 07 00:00:00 EST 2020

Murine CD8 T-cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density.

European journal of immunology

Gilfillan CB,Wang C,Mohsen MO,Rufer N,Hebeisen M,Allard M,Verdeil G,Irvine DJ,Bachmann MF,Speiser DE

Wed Apr 01 00:00:00 EDT 2020

Human T cells employ conserved AU-rich elements to fine-tune IFN-γ production.

European journal of immunology

Freen-van Heeren JJ,Popović B,Guislain A,Wolkers MC

Wed Jul 01 00:00:00 EDT 2020

IL-7Rα^low CD8⁺ T Cells from Healthy Individuals Are Anergic with Defective Glycolysis.

Journal of immunology (Baltimore, Md. : 1950)

Sim JH,Kim JH,Park AK,Lee J,Kim KM,Shin HM,Kim M,Choi K,Choi EY,Kang I,Lee DS,Kim HR

Tue Dec 01 00:00:00 EST 2020

Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions.

Journal of immunology (Baltimore, Md. : 1950)

Watanabe S,Fujino M,Saito Y,Ahmed N,Sato H,Sugimoto C,Okamura T,Hanaki K,Nakayama EE,Shioda T,Matsushima K,Ansari AA,Villinger F,Mori K

Tue Sep 01 00:00:00 EDT 2020

Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity.

Journal of immunology (Baltimore, Md. : 1950)

Høgh RI,Droujinine A,Møller SH,Jepsen SD,Mellergaard M,Andresen L,Skov S

Wed Apr 01 00:00:00 EDT 2020

Reconstitution of Circulating Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation: Its Association with the Riboflavin Synthetic Pathway of Gut Microbiota in Cord Blood Transplant Recipients.

Journal of immunology (Baltimore, Md. : 1950)

Konuma T,Kohara C,Watanabe E,Takahashi S,Ozawa G,Suzuki K,Mizukami M,Nagai E,Jimbo K,Kaito Y,Isobe M,Kato S,Takahashi S,Chiba A,Miyake S,Tojo A

Sun Mar 15 00:00:00 EDT 2020

Synovial fluid CD69⁺CD8⁺ T cells with tissue-resident phenotype mediate perforin-dependent citrullination in rheumatoid arthritis.

Clinical & translational immunology

Jung J,Lee JS,Kim YG,Lee CK,Yoo B,Shin EC,Hong S

Fri Apr 15 00:00:00 EDT 2022

Identifying the optimal donor for natural killer cell adoptive therapy to treat paediatric B- and T-cell acute lymphoblastic leukaemia.

Clinical & translational immunology

Foley B,Ta C,Barnes S,de Jong E,Nguyen M,Cheung LC,Buzzai A,Wagner T,Wylie B,Fernandez S,Cruickshank M,Endersby R,Kees U,Waithman J

Fri Apr 15 00:00:00 EDT 2022

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.

Nature communications

Kared H,Tan SW,Lau MC,Chevrier M,Tan C,How W,Wong G,Strickland M,Malleret B,Amoah A,Pilipow K,Zanon V,Govern NM,Lum J,Chen JM,Lee B,Florian MC,Geiger H,Ginhoux F,Ruiz-Mateos E,Fulop T,Rajasuriar R,Kamarulzaman A,Ng TP,Lugli E,Larbi A

Mon Feb 10 00:00:00 EST 2020

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.

Nature communications

Mon Feb 10 00:00:00 EST 2020

The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56^bright Natural Killer Cells.

Hepatology communications

Hess LU,Martrus G,Ziegler AE,Langeneckert AE,Salzberger W,Goebels H,Sagebiel AF,Hagen SH,Poch T,Ravichandran G,Koch M,Schramm C,Oldhafer KJ,Fischer L,Tiegs G,Richert L,Bunders MJ,Lunemann S,Altfeld M

Sun Mar 01 00:00:00 EST 2020

B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models.

Oncoimmunology

Huang B,Luo L,Wang J,He B,Feng R,Xian N,Zhang Q,Chen L,Huang G

200-15 was used in In vitro experiments to indicate that B7-H3 specific CAR-T cells have the potential to treat multiple types of advanced solid tumors.

Wed Jul 28 00:00:00 EDT 2021

iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity.

Stem cell reports

Suzuki D,Flahou C,Yoshikawa N,Stirblyte I,Hayashi Y,Sawaguchi A,Akasaka M,Nakamura S,Higashi N,Xu H,Matsumoto T,Fujio K,Manz MG,Hotta A,Takizawa H,Eto K,Sugimoto N

Tue Jan 14 00:00:00 EST 2020

GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision.

Nature cancer

Wang K,Chen Y,Ahn S,Zheng M,Landoni E,Dotti G,Savoldo B,Han Z

Thu Oct 01 00:00:00 EDT 2020

Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration.

Cell death & disease

Luo B,Zhan Y,Luo M,Dong H,Liu J,Lin Y,Zhang J,Wang G,Verhoeyen E,Zhang Y,Zhang H

Thu Nov 12 00:00:00 EST 2020

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141⁺ dendritic cells to activate naïve and memory WT1-specific CD8⁺ T cells.

Clinical & translational immunology

Pearson FE,Tullett KM,Leal-Rojas IM,Haigh OL,Masterman KA,Walpole C,Bridgeman JS,McLaren JE,Ladell K,Miners K,Llewellyn-Lacey S,Price DA,Tunger A,Schmitz M,Miles JJ,Lahoud MH,Radford KJ

Fri Apr 15 00:00:00 EDT 2022

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.

Frontiers in immunology

Møller SH,Mellergaard M,Madsen M,Bermejo AV,Jepsen SD,Hansen MH,Høgh RI,Aldana BI,Desler C,Rasmussen LJ,Sustarsic EG,Gerhart-Hines Z,Daskalaki E,Wheelock CE,Hiron TK,Lin D,O'Callaghan CA,Wandall HH,Andresen L,Skov S

200-15 was used in In vitro experiments that cancer cell metabolism supports constitutive surface expression of the NKG2D ligand MHC class I chain-related proteins A (MICA).

Fri Apr 30 00:00:00 EDT 2021

The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer.

Neoplasia (New York, N.Y.)

Hu X,Liu Y,Zhang X,Kong D,Kong J,Zhao D,Guo Y,Sun L,Chu L,Liu S,Hou X,Ren F,Zhao Y,Lu C,Zhai D,Yuan X

200-15 was used in In vitro experiments to evaluate the role(s) of trastuzumab and other antibodies on macrophage activation and Ab-dependent cell-mediated phagocytosis (ADCP) of HER2+ breast cancer cells in vitro and in vivo.

Sun Nov 01 00:00:00 EDT 2020

Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma.

Nature communications

Tseng HC,Xiong W,Badeti S,Yang Y,Ma M,Liu T,Ramos CA,Dotti G,Fritzky L,Jiang JG,Yi Q,Guarrera J,Zong WX,Liu C,Liu D

Wed Sep 23 00:00:00 EDT 2020

convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting.

Communications biology

Landgraf KE,Williams SR,Steiger D,Gebhart D,Lok S,Martin DW,Roybal KT,Kim KC

200-15 was used in Sample Preparation (FC/FACS) to demonstrate that the exclusive ligand-receptor partnering enabled the targeted delivery of a mutant form of IL-2 to selectively promote the expansion of convertibleCAR-T cells in vitro and in vivo.

Tue Jun 09 00:00:00 EDT 2020

convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting.

Communications biology

Landgraf KE,Williams SR,Steiger D,Gebhart D,Lok S,Martin DW,Roybal KT,Kim KC

Tue Jun 09 00:00:00 EDT 2020

Protocol for Isolation, Stimulation and Functional Profiling of Primary and iPSC-derived Human NK Cells.

Bio-protocol

Melsen JE,Themeli M,van Ostaijen-Ten Dam MM,van Beelen E,Lugthart G,Hoeben RC,Schilham MW,Mikkers HM

200-15 was used in In vitro experiments to investigate NK cells classification.

Sat Dec 05 00:00:00 EST 2020

PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes.

Science advances

Menasche BL,Davis EM,Wang S,Ouyang Y,Li S,Yu H,Shen J

200-15 was used in Cell Culture to identify mechanisms utilised by major histocompatibility complex-unrestricted cytotoxic lymphocytes in tumour killing.

Sun Nov 01 00:00:00 EDT 2020

Streamlined selection of cancer antigens for vaccine development through integrative multi-omics and high-content cell imaging.

Scientific reports

Han KC,Park D,Ju S,Lee YE,Heo SH,Kim YA,Lee JE,Lee Y,Park KH,Park SH,Lee HJ,Lee C,Jang M

Fri Apr 03 00:00:00 EDT 2020

Toll-like receptor 7/8-matured RNA-transduced dendritic cells as post-remission therapy in acute myeloid leukaemia: results of a phase I trial.

Clinical & translational immunology

Lichtenegger FS,Schnorfeil FM,Rothe M,Deiser K,Altmann T,Bücklein VL,Köhnke T,Augsberger C,Konstandin NP,Spiekermann K,Moosmann A,Boehm S,Boxberg M,Heemskerk MH,Goerlich D,Wittmann G,Wagner B,Hiddemann W,Schendel DJ,Kvalheim G,Bigalke I,Subklewe M

Wed Apr 13 00:00:00 EDT 2022

Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.

Immunity

Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H

Tue Nov 19 00:00:00 EST 2019

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells.

Cancer cell

Du H,Hirabayashi K,Ahn S,Kren NP,Montgomery SA,Wang X,Tiruthani K,Mirlekar B,Michaud D,Greene K,Herrera SG,Xu Y,Sun C,Chen Y,Ma X,Ferrone CR,Pylayeva-Gupta Y,Yeh JJ,Liu R,Savoldo B,Ferrone S,Dotti G

Mon Feb 11 00:00:00 EST 2019

Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.

Cell stem cell

Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L

200-15 was used in Sample Preparation (FC/FACS) to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.

Thu Oct 03 00:00:00 EDT 2019

Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response.

The Journal of clinical investigation

Sui Y,Lewis GK,Wang Y,Berckmueller K,Frey B,Dzutsev A,Vargas-Inchaustegui D,Mohanram V,Musich T,Shen X,DeVico A,Fouts T,Venzon D,Kirk J,Waters RC,Talton J,Klinman D,Clements J,Tomaras GD,Franchini G,Robert-Guroff M,Trinchieri G,Gallo RC,Berzofsky JA

Fri Mar 01 00:00:00 EST 2019

A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.

The Journal of experimental medicine

Fernandez IZ,Baxter RM,Garcia-Perez JE,Vendrame E,Ranganath T,Kong DS,Lundquist K,Nguyen T,Ogolla S,Black J,Galambos C,Gumbart JC,Dawany N,Kelsen JR,de Zoeten EF,Quinones R,Eissa H,Verneris MR,Sullivan KE,Rochford R,Blish CA,Kedl RM,Dutmer CM,Hsieh EWY

200-15 was used in Enzyme-linked immunosorbent assay to investigate the clinical and immunological phenotypes of two siblings with the first described human IL-2Rβ defect.

Mon Jun 03 00:00:00 EDT 2019

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.

The Journal of experimental medicine

Zhang Z,Gothe F,Pennamen P,James JR,McDonald D,Mata CP,Modis Y,Alazami AM,Acres M,Haller W,Bowen C,Döffinger R,Sinclair J,Brothers S,Zhang Y,Matthews HF,Naudion S,Pelluard F,Alajlan H,Yamazaki Y,Notarangelo LD,Thaventhiran JE,Engelhardt KR,Al-Mousa H,Hambleton S,Rooryck C,Smith KGC,Lenardo MJ

Mon Jun 03 00:00:00 EDT 2019

EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation.

Leukemia

Herviou L,Jourdan M,Martinez AM,Cavalli G,Moreaux J

Thu Aug 01 00:00:00 EDT 2019

MicroRNA-155 Expression Is Enhanced by T-cell Receptor Stimulation Strength and Correlates with Improved Tumor Control in Melanoma.

Cancer immunology research

Martinez-Usatorre A,Sempere LF,Carmona SJ,Carretero-Iglesia L,Monnot G,Speiser DE,Rufer N,Donda A,Zehn D,Jandus C,Romero P

200-15 was used in Cell Culture to explore the regulation of miR-155 expression in CD8+ cells.

Sat Jun 01 00:00:00 EDT 2019

Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Anderson W,Thorpe J,Long SA,Rawlings DJ

Sun Dec 15 00:00:00 EST 2019

CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.

Nature communications

Fan J,Liang H,Ji X,Wang S,Xue J,Li D,Peng H,Qin C,Yee C,Shao Y

Tue May 21 00:00:00 EDT 2019

Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells.

Nature communications

Marquardt N,Kekäläinen E,Chen P,Lourda M,Wilson JN,Scharenberg M,Bergman P,Al-Ameri M,Hård J,Mold JE,Ljunggren HG,Michaëlsson J

Mon Aug 26 00:00:00 EDT 2019

Hexamethylene bisacetamide impairs NK cell-mediated clearance of acute T lymphoblastic leukemia cells and HIV-1-infected T cells that exit viral latency.

Scientific reports

Giuliani E,Desimio MG,Doria M

Wed Mar 13 00:00:00 EDT 2019

CD8⁺ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens.

Nature communications

Pedersen NW,Holm A,Kristensen NP,Bjerregaard AM,Bentzen AK,Marquard AM,Tamhane T,Burgdorf KS,Ullum H,Jennum P,Knudsen S,Hadrup SR,Kornum BR

Tue Feb 19 00:00:00 EST 2019

The R132H mutation in IDH1 promotes the recruitment of NK cells through CX3CL1/CX3CR1 chemotaxis and is correlated with a better prognosis in gliomas.

Immunology and cell biology

Ren F,Zhao Q,Huang L,Zheng Y,Li L,He Q,Zhang C,Li F,Maimela NR,Sun Z,Jia Q,Ping Y,Zhang Z,Chen X,Yue Y,Liu S,Cao L,Zhang Y

200-15 was used in Cell Culture to identify a novel mechanism in which R132H mutation of the IDH1 gene serves as a tumor suppressor by promoting the recruitment of NK cells through CX3CL1/CX3CR1 chemotaxis.

Wed May 01 00:00:00 EDT 2019

Human γδ T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation.

Clinical & translational immunology

Sant S,Jenkins MR,Dash P,Watson KA,Wang Z,Pizzolla A,Koutsakos M,Nguyen TH,Lappas M,Crowe J,Loudovaris T,Mannering SI,Westall GP,Kotsimbos TC,Cheng AC,Wakim L,Doherty PC,Thomas PG,Loh L,Kedzierska K

Sun Apr 10 00:00:00 EDT 2022

Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1.

Blood cancer journal

Ernst D,Williams BA,Wang XH,Yoon N,Kim KP,Chiu J,Luo ZJ,Hermans KG,Krueger J,Keating A

Tue Jan 15 00:00:00 EST 2019

T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients.

Oncoimmunology

Viborg N,Ramskov S,Andersen RS,Sturm T,Fugmann T,Bentzen AK,Rafa VM,Straten PT,Svane IM,Met Ö,Hadrup SR

200-15 was used in Cell Culture to identify T cell targets in breast cancer for future treatment options.

Tue Jan 12 00:00:00 EST 2021

Decidual stromal cells promote the differentiation of CD56^bright CD16^- NK cells by secreting IL-24 in early pregnancy.

American journal of reproductive immunology (New York, N.Y. : 1989)

Yang HL,Zhou WJ,Lu H,Lei ST,Ha SY,Lai ZZ,Zheng ZM,Ruan LY,He YY,Li DJ,Li MQ,Shao J

200-15 was used in Cell Culture to suggest that DSCs promote the differentiation of CD56bright CD16- NK with high levels of inhibitory receptors, immunotolerant, and angiogenic cytokines by secreting IL-24 during decidualization in early pregnancy.

Sat Jun 01 00:00:00 EDT 2019

Low immunogenic endothelial cells endothelialize the Left Ventricular Assist Device.

Scientific reports

Figueiredo C,Eicke D,Yuzefovych Y,Avsar M,Hanke JS,Pflaum M,Schmitto JD,Blasczyk R,Haverich A,Wiegmann B

Mon Aug 05 00:00:00 EDT 2019

Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.

Current protocols in immunology

Souter MNT,Loh L,Li S,Meehan BS,Gherardin NA,Godfrey DI,Rossjohn J,Fairlie DP,Kedzierska K,Pellicci DG,Chen Z,Kjer-Nielsen L,Corbett AJ,McCluskey J,Eckle SBG

200-15 was used in Cell Culture to describe protocols to characterize the phenotype of human MAIT cells in blood and tissues by flow cytometry using fluorescently labeled human MR1 tetramers alongside antibodies specific for MAIT cell markers.

Sun Dec 01 00:00:00 EST 2019

UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.

Scientific reports

Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II

Mon Apr 29 00:00:00 EDT 2019

iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer.

Nature communications

Ding N,Zou Z,Sha H,Su S,Qian H,Meng F,Chen F,Du S,Zhou S,Chen H,Zhang L,Yang J,Wei J,Liu B

Fri Mar 22 00:00:00 EDT 2019

Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β.

Scientific reports

Bonne-Année S,Bush MC,Nutman TB

Fri Oct 04 00:00:00 EDT 2019

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.

Nature

Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C

Sat Dec 01 00:00:00 EST 2018

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.

Nature

Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C

Sat Dec 01 00:00:00 EST 2018

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Cell

Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E

Thu Oct 04 00:00:00 EDT 2018

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Cell

Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E

Thu Oct 04 00:00:00 EDT 2018

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.

Cell

Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M

Thu Jan 25 00:00:00 EST 2018

Innate-like Cytotoxic Function of Bystander-Activated CD8⁺ T Cells Is Associated with Liver Injury in Acute Hepatitis A.

Immunity

Kim J,Chang DY,Lee HW,Lee H,Kim JH,Sung PS,Kim KH,Hong SH,Kang W,Lee J,Shin SY,Yu HT,You S,Choi YS,Oh I,Lee DH,Lee DH,Jung MK,Suh KS,Hwang S,Kim W,Park SH,Kim HJ,Shin EC

Tue Jan 16 00:00:00 EST 2018

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

The Journal of clinical investigation

Miles JJ,Tan MP,Dolton G,Edwards ES,Galloway SA,Laugel B,Clement M,Makinde J,Ladell K,Matthews KK,Watkins TS,Tungatt K,Wong Y,Lee HS,Clark RJ,Pentier JM,Attaf M,Lissina A,Ager A,Gallimore A,Rizkallah PJ,Gras S,Rossjohn J,Burrows SR,Cole DK,Price DA,Sewell AK

Mon Apr 02 00:00:00 EDT 2018

CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection.

The Journal of clinical investigation

Mathews DV,Dong Y,Higginbotham LB,Kim SC,Breeden CP,Stobert EA,Jenkins J,Tso JY,Larsen CP,Adams AB

Mon Oct 01 00:00:00 EDT 2018

High-dimensional single cell analysis identifies stem-like cytotoxic CD8⁺ T cells infiltrating human tumors.

The Journal of experimental medicine

Brummelman J,Mazza EMC,Alvisi G,Colombo FS,Grilli A,Mikulak J,Mavilio D,Alloisio M,Ferrari F,Lopci E,Novellis P,Veronesi G,Lugli E

Mon Oct 01 00:00:00 EDT 2018

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.

Frontiers in immunology

Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M

200-15 was used in Sample Preparation (FC/FACS) to compare the efficacy of dendritic cell receptor-ligand blockades at various immune checkpoints on T cell activation, an suggest targets for enhanced immunotherapy.

Mon Apr 08 00:00:00 EDT 2019

Elevated Hepatic CD1d Levels Coincide with Invariant NKT Cell Defects in Chronic Hepatitis B Virus Infection.

Journal of immunology (Baltimore, Md. : 1950)

Tan X,Ding Y,Zhu P,Dou R,Liang Z,Yang D,Huang Z,Wang W,Wu X,Weng X

Tue May 15 00:00:00 EDT 2018

Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia.

Journal of immunology (Baltimore, Md. : 1950)

Aue G,Sun C,Liu D,Park JH,Pittaluga S,Tian X,Lee E,Soto S,Valdez J,Maric I,Stetler-Stevenson M,Yuan C,Nakamura Y,Muranski P,Wiestner A

Mon Oct 01 00:00:00 EDT 2018

Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells.

Journal of immunology (Baltimore, Md. : 1950)

Otsuka Y,Watanabe E,Shinya E,Okura S,Saeki H,Geijtenbeek TBH,Takahashi H

Thu Nov 15 00:00:00 EST 2018

ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.

Journal of immunology (Baltimore, Md. : 1950)

Hecht I,Toporik A,Podojil JR,Vaknin I,Cojocaru G,Oren A,Aizman E,Liang SC,Leung L,Dicken Y,Novik A,Marbach-Bar N,Elmesmari A,Tange C,Gilmour A,McIntyre D,Kurowska-Stolarska M,McNamee K,Leitner J,Greenwald S,Dassa L,Levine Z,Steinberger P,Williams RO,Miller SD,McInnes IB,Neria E,Rotman G

Thu Mar 15 00:00:00 EDT 2018

IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production.

Journal of immunology (Baltimore, Md. : 1950)

Wagstaffe HR,Nielsen CM,Riley EM,Goodier MR

Sun Apr 15 00:00:00 EDT 2018

Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j.

Journal of immunology (Baltimore, Md. : 1950)

Nuñez SY,Ziblat A,Secchiari F,Torres NI,Sierra JM,Raffo Iraolagoitia XL,Araya RE,Domaica CI,Fuertes MB,Zwirner NW

Thu Feb 01 00:00:00 EST 2018

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.

Nature communications

Kagoya Y,Nakatsugawa M,Saso K,Guo T,Anczurowski M,Wang CH,Butler MO,Arrowsmith CH,Hirano N

Tue May 15 00:00:00 EDT 2018

Enhancing the Activation and Releasing the Brakes: A Double Hit Strategy to Improve NK Cell Cytotoxicity Against Multiple Myeloma.

Frontiers in immunology

Tognarelli S,Wirsching S,von Metzler I,Rais B,Jacobs B,Serve H,Bader P,Ullrich E

200-15 was used in Cell Culture to investigate the potential use of natural killer cell-specific check point inhibitors in multiple myeloma.

Mon Sep 30 00:00:00 EDT 2019

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.

The Journal of biological chemistry

Cribbs A,Hookway ES,Wells G,Lindow M,Obad S,Oerum H,Prinjha RK,Athanasou N,Sowman A,Philpott M,Penn H,Soderstrom K,Feldmann M,Oppermann U

Fri Feb 16 00:00:00 EST 2018

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8⁺ TCR-Vβ⁺ expansions.

Scientific reports

Lissina A,McLaren JE,Ilander M,Andersson EI,Lewis CS,Clement M,Herman A,Ladell K,Llewellyn-Lacey S,Miners KL,Gostick E,Melenhorst JJ,Barrett AJ,Price DA,Mustjoki S,Wooldridge L

Wed Feb 07 00:00:00 EST 2018

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

Scientific reports

Treise I,Huber EM,Klein-Rodewald T,Heinemeyer W,Grassmann SA,Basler M,Adler T,Rathkolb B,Helming L,Andres C,Klaften M,Landbrecht C,Wieland T,Strom TM,McCoy KD,Macpherson AJ,Wolf E,Groettrup M,Ollert M,Neff F,Gailus-Durner V,Fuchs H,Hrabě de Angelis M,Groll M,Busch DH

Fri Apr 13 00:00:00 EDT 2018

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

Scientific reports

Fri Apr 13 00:00:00 EDT 2018

Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response.

Stem cell reports

Ueda N,Uemura Y,Zhang R,Kitayama S,Iriguchi S,Kawai Y,Yasui Y,Tatsumi M,Ueda T,Liu TY,Mizoro Y,Okada C,Watanabe A,Nakanishi M,Senju S,Nishimura Y,Kuzushima K,Kiyoi H,Naoe T,Kaneko S

Tue Jun 05 00:00:00 EDT 2018

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration.

Frontiers in immunology

Parodi M,Raggi F,Cangelosi D,Manzini C,Balsamo M,Blengio F,Eva A,Varesio L,Pietra G,Moretta L,Mingari MC,Vitale M,Bosco MC

200-15 was used in In vitro experiments to study the mechanisms by which hypoxia acts on natural killer cells.

Wed Oct 02 00:00:00 EDT 2019

Origin and differentiation of human memory CD8 T cells after vaccination.

Nature

Akondy RS,Fitch M,Edupuganti S,Yang S,Kissick HT,Li KW,Youngblood BA,Abdelsamed HA,McGuire DJ,Cohen KW,Alexe G,Nagar S,McCausland MM,Gupta S,Tata P,Haining WN,McElrath MJ,Zhang D,Hu B,Greenleaf WJ,Goronzy JJ,Mulligan MJ,Hellerstein M,Ahmed R

Thu Dec 21 00:00:00 EST 2017

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.

Nature

Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A

Thu Nov 02 00:00:00 EDT 2017

Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.

Cell

Jiménez-Sánchez A,Memon D,Pourpe S,Veeraraghavan H,Li Y,Vargas HA,Gill MB,Park KJ,Zivanovic O,Konner J,Ricca J,Zamarin D,Walther T,Aghajanian C,Wolchok JD,Sala E,Merghoub T,Snyder A,Miller ML

Thu Aug 24 00:00:00 EDT 2017

Mitochondrial Priming by CD28.

Cell

Klein Geltink RI,O'Sullivan D,Corrado M,Bremser A,Buck MD,Buescher JM,Firat E,Zhu X,Niedermann G,Caputa G,Kelly B,Warthorst U,Rensing-Ehl A,Kyle RL,Vandersarren L,Curtis JD,Patterson AE,Lawless S,Grzes K,Qiu J,Sanin DE,Kretz O,Huber TB,Janssens S,Lambrecht BN,Rambold AS,Pearce EJ,Pearce EL

Thu Oct 05 00:00:00 EDT 2017

Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.

The Journal of experimental medicine

Nandin IS,Fong C,Deantonio C,Torreno-Pina JA,Pecetta S,Maldonado P,Gasparrini F,Ordovas-Montanes J,Kazer SW,Kjaer S,Borley DW,Nair U,Coleman JA,Lingwood D,Shalek AK,Meffre E,Poignard P,Burton DR,Batista FD

Mon Sep 04 00:00:00 EDT 2017

Curtailed T-cell activation curbs effector differentiation and generates CD8⁺ T cells with a naturally-occurring memory stem cell phenotype.

European journal of immunology

Zanon V,Pilipow K,Scamardella E,De Paoli F,De Simone G,Price DA,Martinez Usatorre A,Romero P,Mavilio D,Roberto A,Lugli E

Fri Sep 01 00:00:00 EDT 2017

CD8⁺ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.

Immunology and cell biology

Dockree T,Holland CJ,Clement M,Ladell K,McLaren JE,van den Berg HA,Gostick E,L Miners K,Llewellyn-Lacey S,Bridgeman JS,Man S,Bailey M,Burrows SR,Price DA,Wooldridge L

Sun Jan 01 00:00:00 EST 2017

Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Schmueck-Henneresse M,Omer B,Shum T,Tashiro H,Mamonkin M,Lapteva N,Sharma S,Rollins L,Dotti G,Reinke P,Volk HD,Rooney CM

Sat Jul 01 00:00:00 EDT 2017

NKG2D Signaling between Human NK Cells Enhances TACE-Mediated TNF-α Release.

Journal of immunology (Baltimore, Md. : 1950)

Sharma N,Trinidad CV,Trembath AP,Markiewicz MA

Sun Oct 15 00:00:00 EDT 2017

Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity.

Scientific reports

Park S,Shevlin E,Vedvyas Y,Zaman M,Park S,Hsu YS,Min IM,Jin MM

Mon Oct 30 00:00:00 EDT 2017

Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells.

Scientific reports

Vahedi F,Nham T,Poznanski SM,Chew MV,Shenouda MM,Lee D,Ashkar AA

Thu Sep 21 00:00:00 EDT 2017

Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.

The Journal of biological chemistry

Cole DK,van den Berg HA,Lloyd A,Crowther MD,Beck K,Ekeruche-Makinde J,Miles JJ,Bulek AM,Dolton G,Schauenburg AJ,Wall A,Fuller A,Clement M,Laugel B,Rizkallah PJ,Wooldridge L,Sewell AK

Fri Jan 20 00:00:00 EST 2017

Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.

Stem cell reports

Zeng J,Tang SY,Toh LL,Wang S

Tue Dec 12 00:00:00 EST 2017

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.

Cell

Gao J,Shi LZ,Zhao H,Chen J,Xiong L,He Q,Chen T,Roszik J,Bernatchez C,Woodman SE,Chen PL,Hwu P,Allison JP,Futreal A,Wargo JA,Sharma P

Thu Oct 06 00:00:00 EDT 2016

Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing.

Cell

Amabile A,Migliara A,Capasso P,Biffi M,Cittaro D,Naldini L,Lombardo A

Thu Sep 22 00:00:00 EDT 2016

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Immunity

Delconte RB,Shi W,Sathe P,Ushiki T,Seillet C,Minnich M,Kolesnik TB,Rankin LC,Mielke LA,Zhang JG,Busslinger M,Smyth MJ,Hutchinson DS,Nutt SL,Nicholson SE,Alexander WS,Corcoran LM,Vivier E,Belz GT,Carotta S,Huntington ND

Tue Jan 19 00:00:00 EST 2016

UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.

Blood

Samudio I,Rezvani K,Shaim H,Hofs E,Ngom M,Bu L,Liu G,Lee JT,Imren S,Lam V,Poon GF,Ghaedi M,Takei F,Humphries K,Jia W,Krystal G

Thu May 26 00:00:00 EDT 2016

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.

The Journal of clinical investigation

Kagoya Y,Nakatsugawa M,Yamashita Y,Ochi T,Guo T,Anczurowski M,Saso K,Butler MO,Arrowsmith CH,Hirano N

Thu Sep 01 00:00:00 EDT 2016

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

The Journal of clinical investigation

Cole DK,Bulek AM,Dolton G,Schauenberg AJ,Szomolay B,Rittase W,Trimby A,Jothikumar P,Fuller A,Skowera A,Rossjohn J,Zhu C,Miles JJ,Peakman M,Wooldridge L,Rizkallah PJ,Sewell AK

Wed Jun 01 00:00:00 EDT 2016

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.

The Journal of experimental medicine

Quek L,Otto GW,Garnett C,Lhermitte L,Karamitros D,Stoilova B,Lau IJ,Doondeea J,Usukhbayar B,Kennedy A,Metzner M,Goardon N,Ivey A,Allen C,Gale R,Davies B,Sternberg A,Killick S,Hunter H,Cahalin P,Price A,Carr A,Griffiths M,Virgo P,Mackinnon S,Grimwade D,Freeman S,Russell N,Craddock C,Mead A,Peniket A,Porcher C,Vyas P

Mon Jul 25 00:00:00 EDT 2016

A Traceless Selection: Counter-selection System That Allows Efficient Generation of Transposon and CRISPR-modified T-cell Products.

Molecular therapy. Nucleic acids

Mezzadra R,Hollenstein A,Gomez-Eerland R,Schumacher TN

Tue Mar 22 00:00:00 EDT 2016

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Molecular therapy. Nucleic acids

Romano Ibarra GS,Paul B,Sather BD,Younan PM,Sommer K,Kowalski JP,Hale M,Stoddard B,Jarjour J,Astrakhan A,Kiem HP,Rawlings DJ

Tue Aug 23 00:00:00 EDT 2016

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

Journal of immunology (Baltimore, Md. : 1950)

Llibre A,López-Macías C,Marafioti T,Mehta H,Partridge A,Kanzig C,Rivellese F,Galson JD,Walker LJ,Milne P,Phillips RE,Kelly DF,Freeman GJ,El Shikh ME,Klenerman P,Willberg CB

Tue Mar 01 00:00:00 EST 2016

Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.

Journal of immunology (Baltimore, Md. : 1950)

Cuff AO,Robertson FP,Stegmann KA,Pallett LJ,Maini MK,Davidson BR,Male V

Thu Dec 01 00:00:00 EST 2016

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.

Journal of immunology (Baltimore, Md. : 1950)

Barros-Martins J,Schmolka N,Fontinha D,Pires de Miranda M,Simas JP,Brok I,Ferreira C,Veldhoen M,Silva-Santos B,Serre K

Sun May 01 00:00:00 EDT 2016

Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection.

Journal of immunology (Baltimore, Md. : 1950)

Goodier MR,Rodriguez-Galan A,Lusa C,Nielsen CM,Darboe A,Moldoveanu AL,White MJ,Behrens R,Riley EM

Fri Jul 01 00:00:00 EDT 2016

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Laugel B,Lloyd A,Meermeier EW,Crowther MD,Connor TR,Dolton G,Miles JJ,Burrows SR,Gold MC,Lewinsohn DM,Sewell AK

Mon Aug 01 00:00:00 EDT 2016

Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells.

The Journal of biological chemistry

Zanetti SR,Ziblat A,Torres NI,Zwirner NW,Bouzat C

Fri Aug 05 00:00:00 EDT 2016

Targeted suppression of autoreactive CD8⁺ T-cell activation using blocking anti-CD8 antibodies.

Scientific reports

Clement M,Pearson JA,Gras S,van den Berg HA,Lissina A,Llewellyn-Lacey S,Willis MD,Dockree T,McLaren JE,Ekeruche-Makinde J,Gostick E,Robertson NP,Rossjohn J,Burrows SR,Price DA,Wong FS,Peakman M,Skowera A,Wooldridge L

Mon Oct 17 00:00:00 EDT 2016

Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.

Nature communications

Serr I,Fürst RW,Achenbach P,Scherm MG,Gökmen F,Haupt F,Sedlmeier EM,Knopff A,Shultz L,Willis RA,Ziegler AG,Daniel C

Tue Mar 15 00:00:00 EDT 2016

CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.

Scientific reports

Nakatsugawa M,Rahman MA,Yamashita Y,Ochi T,Wnuk P,Tanaka S,Chamoto K,Kagoya Y,Saso K,Guo T,Anczurowski M,Butler MO,Hirano N

Thu Mar 31 00:00:00 EDT 2016

Soluble γc cytokine receptor suppresses IL-15 signaling and impairs iNKT cell development in the thymus.

Scientific reports

Park JY,Jo Y,Ko E,Luckey MA,Park YK,Park SH,Park JH,Hong C

Fri Nov 11 00:00:00 EST 2016

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.

Nature communications

Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM

Mon Nov 21 00:00:00 EST 2016

Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities.

The Journal of biological chemistry

Velásquez SY,Killian D,Schulte J,Sticht C,Thiel M,Lindner HA

Fri Jun 17 00:00:00 EDT 2016

The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling.

The Journal of biological chemistry

Lykken EA,Li QJ

Fri Nov 04 00:00:00 EDT 2016

High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens.

Blood

Wegner J,Hackenberg S,Scholz CJ,Chuvpilo S,Tyrsin D,Matskevich AA,Grigoleit GU,Stevanović S,Hünig T

Thu Jul 09 00:00:00 EDT 2015

Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.

Blood

Roberto A,Castagna L,Zanon V,Bramanti S,Crocchiolo R,McLaren JE,Gandolfi S,Tentorio P,Sarina B,Timofeeva I,Santoro A,Carlo-Stella C,Bruno B,Carniti C,Corradini P,Gostick E,Ladell K,Price DA,Roederer M,Mavilio D,Lugli E

Thu Apr 30 00:00:00 EDT 2015

Inflammatory IL-15 is required for optimal memory T cell responses.

The Journal of clinical investigation

Richer MJ,Pewe LL,Hancox LS,Hartwig SM,Varga SM,Harty JT

Tue Sep 01 00:00:00 EDT 2015

Survivin-specific T cell receptor targets tumor but not T cells.

The Journal of clinical investigation

Arber C,Feng X,Abhyankar H,Romero E,Wu MF,Heslop HE,Barth P,Dotti G,Savoldo B

Thu Jan 01 00:00:00 EST 2015

Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes.

Proceedings of the National Academy of Sciences of the United States of America

Tilburgs T,Crespo ÂC,van der Zwan A,Rybalov B,Raj T,Stranger B,Gardner L,Moffett A,Strominger JL

Tue Jun 09 00:00:00 EDT 2015

The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface.

Proceedings of the National Academy of Sciences of the United States of America

Tilburgs T,Evans JH,Crespo ÂC,Strominger JL

Tue Oct 27 00:00:00 EDT 2015

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.

Proceedings of the National Academy of Sciences of the United States of America

Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X

Tue Dec 29 00:00:00 EST 2015

Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.

Aging cell

van der Geest KS,Abdulahad WH,Teteloshvili N,Tete SM,Peters JH,Horst G,Lorencetti PG,Bos NA,Lambeck A,Roozendaal C,Kroesen BJ,Koenen HJ,Joosten I,Brouwer E,Boots AM

Thu Oct 01 00:00:00 EDT 2015

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells.

Clinical and experimental immunology

Tan MP,Gerry AB,Brewer JE,Melchiori L,Bridgeman JS,Bennett AD,Pumphrey NJ,Jakobsen BK,Price DA,Ladell K,Sewell AK

Fri May 01 00:00:00 EDT 2015

Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.

Journal of immunology (Baltimore, Md. : 1950)

Bending D,Giannakopoulou E,Lom H,Wedderburn LR

Tue Dec 15 00:00:00 EST 2015

CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28-CD8+ T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Leitner J,Herndler-Brandstetter D,Zlabinger GJ,Grubeck-Loebenstein B,Steinberger P

Wed Jul 15 00:00:00 EDT 2015

Tissue-Specific Education of Decidual NK Cells.

Journal of immunology (Baltimore, Md. : 1950)

Sharkey AM,Xiong S,Kennedy PR,Gardner L,Farrell LE,Chazara O,Ivarsson MA,Hiby SE,Colucci F,Moffett A

Thu Oct 01 00:00:00 EDT 2015

Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.

Journal of immunology (Baltimore, Md. : 1950)

Mattiola I,Pesant M,Tentorio PF,Molgora M,Marcenaro E,Lugli E,Locati M,Mavilio D

Tue Sep 15 00:00:00 EDT 2015

Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.

Journal of immunology (Baltimore, Md. : 1950)

Spallanzani RG,Torres NI,Avila DE,Ziblat A,Iraolagoitia XL,Rossi LE,Domaica CI,Fuertes MB,Rabinovich GA,Zwirner NW

Tue Sep 01 00:00:00 EDT 2015

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Marquardt N,Béziat V,Nyström S,Hengst J,Ivarsson MA,Kekäläinen E,Johansson H,Mjösberg J,Westgren M,Lankisch TO,Wedemeyer H,Ellis EC,Ljunggren HG,Michaëlsson J,Björkström NK

Sun Mar 15 00:00:00 EDT 2015

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.

Journal of immunology (Baltimore, Md. : 1950)

Tungatt K,Bianchi V,Crowther MD,Powell WE,Schauenburg AJ,Trimby A,Donia M,Miles JJ,Holland CJ,Cole DK,Godkin AJ,Peakman M,Straten PT,Svane IM,Sewell AK,Dolton G

Thu Jan 01 00:00:00 EST 2015

Specific roles of each TCR hemichain in generating functional chain-centric TCR.

Journal of immunology (Baltimore, Md. : 1950)

Nakatsugawa M,Yamashita Y,Ochi T,Tanaka S,Chamoto K,Guo T,Butler MO,Hirano N

Wed Apr 01 00:00:00 EDT 2015

Knowledge, Behavioral, and Sociocultural Factors Related to Human Papillomavirus Infection and Cervical Cancer Screening Among Inner-City Women in Panama.

Journal of community health

Vamos CA,Calvo AE,Daley EM,Giuliano AR,López Castillo H

Tue Dec 01 00:00:00 EST 2015

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.

Scientific reports

Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J

Mon Oct 12 00:00:00 EDT 2015

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.

Scientific reports

Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J

Mon Oct 12 00:00:00 EDT 2015

Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.

The Journal of biological chemistry

Nata T,Basheer A,Cocchi F,van Besien R,Massoud R,Jacobson S,Azimi N,Tagaya Y

Fri Sep 11 00:00:00 EDT 2015

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

The Journal of biological chemistry

Tokarski JS,Zupa-Fernandez A,Tredup JA,Pike K,Chang C,Xie D,Cheng L,Pedicord D,Muckelbauer J,Johnson SR,Wu S,Edavettal SC,Hong Y,Witmer MR,Elkin LL,Blat Y,Pitts WJ,Weinstein DS,Burke JR

Fri Apr 24 00:00:00 EDT 2015

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.

Cell death & disease

Six E,Lagresle-Peyrou C,Susini S,De Chappedelaine C,Sigrist N,Sadek H,Chouteau M,Cagnard N,Fontenay M,Hermine O,Chomienne C,Reynier P,Fischer A,André-Schmutz I,Gueguen N,Cavazzana M

Thu Aug 13 00:00:00 EDT 2015

TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance.

Oncoimmunology

Guerville F,Daburon S,Marlin R,Lartigue L,Loizon S,Pitard V,Couzi L,Moreau JF,Déchanet-Merville J,Faustin B

200-15 was used in In vitro experiments to investigate the relationship between inflammasome secreted by tumor cells and γδ cell immusurveillance.

Fri May 01 00:00:00 EDT 2015

Targeted genome editing in human repopulating haematopoietic stem cells.

Nature

Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L

Thu Jun 12 00:00:00 EDT 2014

Targeted genome editing in human repopulating haematopoietic stem cells.

Nature

Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L

Thu Jun 12 00:00:00 EDT 2014

Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

Immunity

Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR

Thu Sep 18 00:00:00 EDT 2014

Blood

Xu Y,Zhang M,Ramos CA,Durett A,Liu E,Dakhova O,Liu H,Creighton CJ,Gee AP,Heslop HE,Rooney CM,Savoldo B,Dotti G

Thu Jun 12 00:00:00 EDT 2014

Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia.

Blood

Williams MT,Yousafzai Y,Cox C,Blair A,Carmody R,Sai S,Chapman KE,McAndrew R,Thomas A,Spence A,Gibson B,Graham GJ,Halsey C

Thu May 15 00:00:00 EDT 2014

Vaccine-induced myeloid cell population dampens protective immunity to SIV.

The Journal of clinical investigation

Sui Y,Hogg A,Wang Y,Frey B,Yu H,Xia Z,Venzon D,McKinnon K,Smedley J,Gathuka M,Klinman D,Keele BF,Langermann S,Liu L,Franchini G,Berzofsky JA

Sun Jun 01 00:00:00 EDT 2014

Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.

The Journal of clinical investigation

Jandus C,Boligan KF,Chijioke O,Liu H,Dahlhaus M,Démoulins T,Schneider C,Wehrli M,Hunger RE,Baerlocher GM,Simon HU,Romero P,Münz C,von Gunten S

Tue Apr 01 00:00:00 EDT 2014

Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes.

Proceedings of the National Academy of Sciences of the United States of America

Kumari S,Wälchli S,Fallang LE,Yang W,Lund-Johansen F,Schumacher TN,Olweus J

Tue Jan 07 00:00:00 EST 2014

Diversity and clonal selection in the human T-cell repertoire.

Proceedings of the National Academy of Sciences of the United States of America

Qi Q,Liu Y,Cheng Y,Glanville J,Zhang D,Lee JY,Olshen RA,Weyand CM,Boyd SD,Goronzy JJ

Tue Sep 09 00:00:00 EDT 2014

IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells.

Proceedings of the National Academy of Sciences of the United States of America

Tamzalit F,Barbieux I,Plet A,Heim J,Nedellec S,Morisseau S,Jacques Y,Mortier E

Tue Jun 10 00:00:00 EDT 2014

5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies.

Blood cancer journal

Gang AO,Frøsig TM,Brimnes MK,Lyngaa R,Treppendahl MB,Grønbæk K,Dufva IH,Straten PT,Hadrup SR

Fri Mar 28 00:00:00 EDT 2014

Activin A as a mediator of NK-dendritic cell functional interactions.

Journal of immunology (Baltimore, Md. : 1950)

Seeger P,Bosisio D,Parolini S,Badolato R,Gismondi A,Santoni A,Sozzani S

Sat Feb 01 00:00:00 EST 2014

Tissue-specific microvascular endothelial cells show distinct capacity to activate NK cells: implications for the pathophysiology of granulomatosis with polyangiitis.

Journal of immunology (Baltimore, Md. : 1950)

Tognarelli S,Gayet J,Lambert M,Dupuy S,Karras A,Cohen P,Guillevin L,de Menthon M,Caillat-Zucman S

Tue Apr 01 00:00:00 EDT 2014

Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration.

Journal of immunology (Baltimore, Md. : 1950)

Arneja A,Johnson H,Gabrovsek L,Lauffenburger DA,White FM

Wed Jan 01 00:00:00 EST 2014

The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.

Journal of immunology (Baltimore, Md. : 1950)

Uhlenbrock F,Hagemann-Jensen M,Kehlet S,Andresen L,Pastorekova S,Skov S

Fri Aug 15 00:00:00 EDT 2014

Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy.

Journal of immunology (Baltimore, Md. : 1950)

Kim PS,Jochems C,Grenga I,Donahue RN,Tsang KY,Gulley JL,Schlom J,Farsaci B

Sat Mar 15 00:00:00 EDT 2014

Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1.

Journal of immunology (Baltimore, Md. : 1950)

Duluc D,Joo H,Ni L,Yin W,Upchurch K,Li D,Xue Y,Klucar P,Zurawski S,Zurawski G,Oh S

Sun Jun 15 00:00:00 EDT 2014

Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.

Journal of immunology (Baltimore, Md. : 1950)

Stärck L,Popp K,Pircher H,Uckert W

Wed Jan 01 00:00:00 EST 2014

TL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes.

PloS one

Reichwald K,Jørgensen TZ,Tougaard P,Skov S

200-15 was used in In vitro experiments to investigate the role of the cytokine TL1A in autoimmune disease, showing that it induces the production of IL-6 and TNF-alpha, suggesting that it could be a possible target for the treatment of autoimmune disease

Mon Sep 08 00:00:00 EDT 2014

Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.

Immunity

Fuchs A,Vermi W,Lee JS,Lonardi S,Gilfillan S,Newberry RD,Cella M,Colonna M

Thu Apr 18 00:00:00 EDT 2013

Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.

Immunity

Fuchs A,Vermi W,Lee JS,Lonardi S,Gilfillan S,Newberry RD,Cella M,Colonna M

Thu Apr 18 00:00:00 EDT 2013

Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.

Blood

Wölfl M,Schwinn S,Yoo YE,Reß ML,Braun M,Chopra M,Schreiber SC,Ayala VI,Ohlen C,Eyrich M,Beilhack A,Schlegel PG

Thu Aug 15 00:00:00 EDT 2013

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.

Blood

Mace EM,Hsu AP,Monaco-Shawver L,Makedonas G,Rosen JB,Dropulic L,Cohen JI,Frenkel EP,Bagwell JC,Sullivan JL,Biron CA,Spalding C,Zerbe CS,Uzel G,Holland SM,Orange JS

Thu Apr 04 00:00:00 EDT 2013

The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation.

Blood

Das R,Bassiri H,Guan P,Wiener S,Banerjee PP,Zhong MC,Veillette A,Orange JS,Nichols KE

Thu Apr 25 00:00:00 EDT 2013

Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.

Blood

Miyazaki Y,Fujiwara H,Asai H,Ochi F,Ochi T,Azuma T,Ishida T,Okamoto S,Mineno J,Kuzushima K,Shiku H,Yasukawa M

Thu Jun 13 00:00:00 EDT 2013

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.

Blood

Casucci M,Nicolis di Robilant B,Falcone L,Camisa B,Norelli M,Genovese P,Gentner B,Gullotta F,Ponzoni M,Bernardi M,Marcatti M,Saudemont A,Bordignon C,Savoldo B,Ciceri F,Naldini L,Dotti G,Bonini C,Bondanza A

Thu Nov 14 00:00:00 EST 2013

Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia.

Blood

Waldmann TA,Conlon KC,Stewart DM,Worthy TA,Janik JE,Fleisher TA,Albert PS,Figg WD,Spencer SD,Raffeld M,Decker JR,Goldman CK,Bryant BR,Petrus MN,Creekmore SP,Morris JC

Thu Jan 17 00:00:00 EST 2013

Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia.

Blood

Waldmann TA,Conlon KC,Stewart DM,Worthy TA,Janik JE,Fleisher TA,Albert PS,Figg WD,Spencer SD,Raffeld M,Decker JR,Goldman CK,Bryant BR,Petrus MN,Creekmore SP,Morris JC

Thu Jan 17 00:00:00 EST 2013

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors.

Blood

Torikai H,Reik A,Soldner F,Warren EH,Yuen C,Zhou Y,Crossland DL,Huls H,Littman N,Zhang Z,Tykodi SS,Kebriaei P,Lee DA,Miller JC,Rebar EJ,Holmes MC,Jaenisch R,Champlin RE,Gregory PD,Cooper LJ

Thu Aug 22 00:00:00 EDT 2013

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.

Blood

Cieri N,Camisa B,Cocchiarella F,Forcato M,Oliveira G,Provasi E,Bondanza A,Bordignon C,Peccatori J,Ciceri F,Lupo-Stanghellini MT,Mavilio F,Mondino A,Bicciato S,Recchia A,Bonini C

Thu Jan 24 00:00:00 EST 2013

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.

The Journal of clinical investigation

Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN

Thu Aug 01 00:00:00 EDT 2013

Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.

Proceedings of the National Academy of Sciences of the United States of America

Fu B,Li X,Sun R,Tong X,Ling B,Tian Z,Wei H

Tue Jan 15 00:00:00 EST 2013

MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.

Journal of immunology (Baltimore, Md. : 1950)

Sullivan RP,Fogel LA,Leong JW,Schneider SE,Wong R,Romee R,Thai TH,Sexl V,Matkovich SJ,Dorn GW,French AR,Fehniger TA

Sun Dec 15 00:00:00 EST 2013

CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation.

Journal of immunology (Baltimore, Md. : 1950)

Ponzetta A,Sciumè G,Benigni G,Antonangeli F,Morrone S,Santoni A,Bernardini G

Sun Dec 01 00:00:00 EST 2013

Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors.

Journal of immunology (Baltimore, Md. : 1950)

Cerdeira AS,Rajakumar A,Royle CM,Lo A,Husain Z,Thadhani RI,Sukhatme VP,Karumanchi SA,Kopcow HD

Mon Apr 15 00:00:00 EDT 2013

Uterine NK cells regulate endometrial bleeding in women and are suppressed by the progesterone receptor modulator asoprisnil.

Journal of immunology (Baltimore, Md. : 1950)

Wilkens J,Male V,Ghazal P,Forster T,Gibson DA,Williams AR,Brito-Mutunayagam SL,Craigon M,Lourenco P,Cameron IT,Chwalisz K,Moffett A,Critchley HO

Sun Sep 01 00:00:00 EDT 2013

Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.

Journal of immunology (Baltimore, Md. : 1950)

Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Imai K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y

Sat Jun 15 00:00:00 EDT 2013

IL-21 enhances phagocytosis in mononuclear phagocyte cells: identification of spleen tyrosine kinase as a novel molecular target of IL-21.

Journal of immunology (Baltimore, Md. : 1950)

Vallières F,Girard D

Fri Mar 15 00:00:00 EDT 2013

Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.

PloS one

Asai H,Fujiwara H,An J,Ochi T,Miyazaki Y,Nagai K,Okamoto S,Mineno J,Kuzushima K,Shiku H,Inoue H,Yasukawa M

Tue Aug 13 00:00:00 EDT 2013

IGF-1 promotes the development and cytotoxic activity of human NK cells.

Nature communications

Ni F,Sun R,Fu B,Wang F,Guo C,Tian Z,Wei H

Thu Jun 20 00:00:00 EDT 2013

High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.

Blood

Zocchi MR,Catellani S,Canevali P,Tavella S,Garuti A,Villaggio B,Zunino A,Gobbi M,Fraternali-Orcioni G,Kunkl A,Ravetti JL,Boero S,Musso A,Poggi A

Thu Feb 09 00:00:00 EST 2012

Dasatinib enhances the expansion of CD56+CD3- NK cells from cord blood.

Blood

Tanaka J,Sugita J,Shiratori S,Shigematsu A,Imamura M

Thu Jun 21 00:00:00 EDT 2012

Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity.

Blood

Nagai K,Ochi T,Fujiwara H,An J,Shirakata T,Mineno J,Kuzushima K,Shiku H,Melenhorst JJ,Gostick E,Price DA,Ishii E,Yasukawa M

Thu Jan 12 00:00:00 EST 2012

Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa).

Blood

Couzi L,Pitard V,Sicard X,Garrigue I,Hawchar O,Merville P,Moreau JF,Déchanet-Merville J

Thu Feb 09 00:00:00 EST 2012

IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.

The Journal of clinical investigation

Liu D,Song L,Wei J,Courtney AN,Gao X,Marinova E,Guo L,Heczey A,Asgharzadeh S,Kim E,Dotti G,Metelitsa LS

Fri Jun 01 00:00:00 EDT 2012

K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.

Proceedings of the National Academy of Sciences of the United States of America

Singh K,Deshpande P,Li G,Yu M,Pryshchep S,Cavanagh M,Weyand CM,Goronzy JJ

Tue Jun 19 00:00:00 EDT 2012

TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence.

PLoS pathogens

Sun C,Fu B,Gao Y,Liao X,Sun R,Tian Z,Wei H

Mon Jul 09 00:00:00 EDT 2012

IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model.

Journal of molecular medicine (Berlin, Germany)

Schilling B,Harasymczuk M,Schuler P,Egan JE,Whiteside TL

Wed Feb 01 00:00:00 EST 2012

Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Journal of immunology (Baltimore, Md. : 1950)

Lissauer D,Piper K,Goodyear O,Kilby MD,Moss PA

Sun Jul 15 00:00:00 EDT 2012

IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells.

Journal of immunology (Baltimore, Md. : 1950)

Imataki O,Ansén S,Tanaka M,Butler MO,Berezovskaya A,Milstein MI,Kuzushima K,Nadler LM,Hirano N

Wed Feb 15 00:00:00 EST 2012

CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.

Journal of immunology (Baltimore, Md. : 1950)

Hervas-Stubbs S,Mancheño U,Riezu-Boj JI,Larraga A,Ochoa MC,Alignani D,Alfaro C,Morales-Kastresana A,Gonzalez I,Larrea E,Pircher H,Le Bon A,Lopez-Picazo JM,Martín-Algarra S,Prieto J,Melero I

Mon Oct 01 00:00:00 EDT 2012

Identification of circulating human antigen-reactive CD4+ FOXP3+ natural regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Litjens NH,Boer K,Betjes MG

Wed Feb 01 00:00:00 EST 2012

Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency.

Journal of immunology (Baltimore, Md. : 1950)

Fuchs S,Rensing-Ehl A,Speckmann C,Bengsch B,Schmitt-Graeff A,Bondzio I,Maul-Pavicic A,Bass T,Vraetz T,Strahm B,Ankermann T,Benson M,Caliebe A,Fölster-Holst R,Kaiser P,Thimme R,Schamel WW,Schwarz K,Feske S,Ehl S

Wed Feb 01 00:00:00 EST 2012

IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.

Journal of immunology (Baltimore, Md. : 1950)

Paine A,Kirchner H,Immenschuh S,Oelke M,Blasczyk R,Eiz-Vesper B

Wed Feb 15 00:00:00 EST 2012

Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells.

PloS one

Jensen H,Folkersen L,Skov S

Tue Feb 19 00:00:00 EST 2013

Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure.

Oncoimmunology

Wilde S,Geiger C,Milosevic S,Mosetter B,Eichenlaub S,Schendel DJ

Thu Mar 01 00:00:00 EST 2012

IL-15 augments TCR-induced CD4+ T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4+ T cells.

PloS one

Van Belle TL,Dooms H,Boonefaes T,Wei XQ,Leclercq G,Grooten J

Thu Feb 28 00:00:00 EST 2013

Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma.

BMC cancer

Blix ES,Irish JM,Husebekk A,Delabie J,Forfang L,Tierens AM,Myklebust JH,Kolstad A

Tue Oct 16 00:00:00 EDT 2012

MiRNA-mediated control of HLA-G expression and function.

PloS one

Manaster I,Goldman-Wohl D,Greenfield C,Nachmani D,Tsukerman P,Hamani Y,Yagel S,Mandelboim O

Mon Aug 13 00:00:00 EDT 2012

Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.

PloS one

Nielsen N,Ødum N,Ursø B,Lanier LL,Spee P

Mon Aug 27 00:00:00 EDT 2012

T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.

The Journal of biological chemistry

Ekeruche-Makinde J,Clement M,Cole DK,Edwards ES,Ladell K,Miles JJ,Matthews KK,Fuller A,Lloyd KA,Madura F,Dolton GM,Pentier J,Lissina A,Gostick E,Baxter TK,Baker BM,Rizkallah PJ,Price DA,Wooldridge L,Sewell AK

Fri Oct 26 00:00:00 EDT 2012

Autophagy creates a CTL epitope that mimics tumor-associated antigens.

PloS one

Demachi-Okamura A,Torikai H,Akatsuka Y,Miyoshi H,Yoshimori T,Kuzushima K

Wed May 01 00:00:00 EDT 2013

MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.

PloS one

Testa JS,Shetty V,Hafner J,Nickens Z,Kamal S,Sinnathamby G,Philip R

Wed Apr 24 00:00:00 EDT 2013

Human natural killer cell maturation defect supports in vivo CD56(bright) to CD56(dim) lineage development.

PloS one

Domaica CI,Fuertes MB,Uriarte I,Girart MV,Sardañons J,Comas DI,Di Giovanni D,Gaillard MI,Bezrodnik L,Zwirner NW

Thu May 30 00:00:00 EDT 2013

Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.

The Journal of biological chemistry

Mitra A,Ross JA,Rodriguez G,Nagy ZS,Wilson HL,Kirken RA

Fri May 11 00:00:00 EDT 2012

Activation of STAT6 by STING is critical for antiviral innate immunity.

Cell

Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z

Fri Oct 14 00:00:00 EDT 2011

A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.

Immunity

Siegel AM,Heimall J,Freeman AF,Hsu AP,Brittain E,Brenchley JM,Douek DC,Fahle GH,Cohen JI,Holland SM,Milner JD

Wed Nov 23 00:00:00 EST 2011

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

Blood

Bluteau D,Gilles L,Hilpert M,Antony-Debré I,James C,Debili N,Camara-Clayette V,Wagner-Ballon O,Cordette-Lagarde V,Robert T,Ripoche H,Gonin P,Swierczek S,Prchal J,Vainchenker W,Favier R,Raslova H

Thu Dec 08 00:00:00 EST 2011

IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.

Blood

Bondanza A,Hambach L,Aghai Z,Nijmeijer B,Kaneko S,Mastaglio S,Radrizzani M,Fleischhauer K,Ciceri F,Bordignon C,Bonini C,Goulmy E

Thu Jun 16 00:00:00 EDT 2011

Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety.

Blood

Ochi T,Fujiwara H,Okamoto S,An J,Nagai K,Shirakata T,Mineno J,Kuzushima K,Shiku H,Yasukawa M

Thu Aug 11 00:00:00 EDT 2011

STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.

Blood

Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E

Thu Jan 06 00:00:00 EST 2011

Severe impairment of IFN-γ and IFN-α responses in cells of a patient with a novel STAT1 splicing mutation.

Blood

Vairo D,Tassone L,Tabellini G,Tamassia N,Gasperini S,Bazzoni F,Plebani A,Porta F,Notarangelo LD,Parolini S,Giliani S,Badolato R

Thu Aug 18 00:00:00 EDT 2011

Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.

Blood

Park YP,Choi SC,Kiesler P,Gil-Krzewska A,Borrego F,Weck J,Krzewski K,Coligan JE

Thu Sep 15 00:00:00 EDT 2011

Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.

Blood

Sato N,Sabzevari H,Fu S,Ju W,Petrus MN,Bamford RN,Waldmann TA,Tagaya Y

Thu Apr 14 00:00:00 EDT 2011

CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow.

Blood

Sciumè G,De Angelis G,Benigni G,Ponzetta A,Morrone S,Santoni A,Bernardini G

Thu Apr 28 00:00:00 EDT 2011

Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell-invasive merozoites.

Blood

Costa G,Loizon S,Guenot M,Mocan I,Halary F,de Saint-Basile G,Pitard V,Déchanet-Merville J,Moreau JF,Troye-Blomberg M,Mercereau-Puijalon O,Behr C

Thu Dec 22 00:00:00 EST 2011

A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans.

The Journal of clinical investigation

Kim HY,Eyheramonho MB,Pichavant M,Gonzalez Cambaceres C,Matangkasombut P,Cervio G,Kuperman S,Moreiro R,Konduru K,Manangeeswaran M,Freeman GJ,Kaplan GG,DeKruyff RH,Umetsu DT,Rosenzweig SD

Tue Mar 01 00:00:00 EST 2011

Revisiting human natural killer cell subset function revealed cytolytic CD56(dim)CD16+ NK cells as rapid producers of abundant IFN-gamma on activation.

Proceedings of the National Academy of Sciences of the United States of America

De Maria A,Bozzano F,Cantoni C,Moretta L

Tue Jan 11 00:00:00 EST 2011

ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis.

Proceedings of the National Academy of Sciences of the United States of America

Maul-Pavicic A,Chiang SC,Rensing-Ehl A,Jessen B,Fauriat C,Wood SM,Sjöqvist S,Hufnagel M,Schulze I,Bass T,Schamel WW,Fuchs S,Pircher H,McCarl CA,Mikoshiba K,Schwarz K,Feske S,Bryceson YT,Ehl S

Tue Feb 22 00:00:00 EST 2011

Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells.

Cancer immunology, immunotherapy : CII

Buddingh EP,Schilham MW,Ruslan SE,Berghuis D,Szuhai K,Suurmond J,Taminiau AH,Gelderblom H,Egeler RM,Serra M,Hogendoorn PC,Lankester AC

Fri Apr 01 00:00:00 EDT 2011

Two modes of lytic granule fusion during degranulation by natural killer cells.

Immunology and cell biology

Liu D,Martina JA,Wu XS,Hammer JA,Long EO

Mon Aug 01 00:00:00 EDT 2011

Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction.

Journal of immunology (Baltimore, Md. : 1950)

Kim YJ,Park SJ,Broxmeyer HE

Thu Sep 01 00:00:00 EDT 2011

Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Kleijwegt FS,Laban S,Duinkerken G,Joosten AM,Koeleman BP,Nikolic T,Roep BO

Thu Dec 15 00:00:00 EST 2011

Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80.

Journal of immunology (Baltimore, Md. : 1950)

Haile ST,Bosch JJ,Agu NI,Zeender AM,Somasundaram P,Srivastava MK,Britting S,Wolf JB,Ksander BR,Ostrand-Rosenberg S

Wed Jun 15 00:00:00 EDT 2011

Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Muralidharan S,Hanley PJ,Liu E,Chakraborty R,Bollard C,Shpall E,Rooney C,Savoldo B,Rodgers J,Dotti G

Tue Nov 15 00:00:00 EST 2011

High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations.

PloS one

Hombrink P,Hadrup SR,Bakker A,Kester MG,Falkenburg JH,von dem Borne PA,Schumacher TN,Heemskerk MH

Thu Feb 02 00:00:00 EST 2012

Differentiation of chronic lymphocytic leukemia B cells into immunoglobulin secreting cells decreases LEF-1 expression.

PloS one

Gutierrez A,Arendt BK,Tschumper RC,Kay NE,Zent CS,Jelinek DF

Mon Feb 13 00:00:00 EST 2012

KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation.

PloS one

Hanvesakul R,Kubal C,Moore J,Neil D,Cook M,Ball S,Briggs D,Moss P,Cockwell P

Fri Dec 23 00:00:00 EST 2011

IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.

PloS one

Sammicheli S,Dang VP,Ruffin N,Pham HT,Lantto R,Vivar N,Chiodi F,Rethi B

Mon Aug 27 00:00:00 EDT 2012

Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.

PloS one

Yu Y,Zitzner JR,Houlihan J,Herrera N,Xu L,Miller J,Mathew JM,Tambur AR,Luo X

Mon Aug 27 00:00:00 EDT 2012

Identification of constitutively active interleukin 33 (IL-33) splice variant.

The Journal of biological chemistry

Hong J,Bae S,Jhun H,Lee S,Choi J,Kang T,Kwak A,Hong K,Kim E,Jo S,Kim S

Fri Jun 03 00:00:00 EDT 2011

Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates.

Blood

Lugli E,Goldman CK,Perera LP,Smedley J,Pung R,Yovandich JL,Creekmore SP,Waldmann TA,Roederer M

Thu Oct 28 00:00:00 EDT 2010

LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis.

Blood

Gutierrez A,Tschumper RC,Wu X,Shanafelt TD,Eckel-Passow J,Huddleston PM,Slager SL,Kay NE,Jelinek DF

Thu Oct 21 00:00:00 EDT 2010

Regulation of human NK-cell cytokine and chemokine production by target cell recognition.

Blood

Fauriat C,Long EO,Ljunggren HG,Bryceson YT

Thu Mar 18 00:00:00 EDT 2010

IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter.

Proceedings of the National Academy of Sciences of the United States of America

Kis LL,Salamon D,Persson EK,Nagy N,Scheeren FA,Spits H,Klein G,Klein E

Tue Jan 12 00:00:00 EST 2010

Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques.

Proceedings of the National Academy of Sciences of the United States of America

Sui Y,Zhu Q,Gagnon S,Dzutsev A,Terabe M,Vaccari M,Venzon D,Klinman D,Strober W,Kelsall B,Franchini G,Belyakov IM,Berzofsky JA

Tue May 25 00:00:00 EDT 2010

Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950)

Saikali P,Antel JP,Pittet CL,Newcombe J,Arbour N

Mon Nov 15 00:00:00 EST 2010

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

Journal of immunology (Baltimore, Md. : 1950)

Wooldridge L,Clement M,Lissina A,Edwards ES,Ladell K,Ekeruche J,Hewitt RE,Laugel B,Gostick E,Cole DK,Debets R,Berrevoets C,Miles JJ,Burrows SR,Price DA,Sewell AK

Thu Apr 01 00:00:00 EDT 2010

A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.

Journal of immunology (Baltimore, Md. : 1950)

Liang X,Weigand LU,Schuster IG,Eppinger E,van der Griendt JC,Schub A,Leisegang M,Sommermeyer D,Anderl F,Han Y,Ellwart J,Moosmann A,Busch DH,Uckert W,Peschel C,Krackhardt AM

Mon Feb 01 00:00:00 EST 2010

Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.

Journal of immunology (Baltimore, Md. : 1950)

Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I

Thu Jul 15 00:00:00 EDT 2010

An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Martin JF,Perry JS,Jakhete NR,Wang X,Bielekova B

Thu Jul 15 00:00:00 EDT 2010

Resistance of CD45RA- T cells to apoptosis and functional impairment, and activation of tumor-antigen specific T cells during radiation therapy of prostate cancer.

Journal of immunology (Baltimore, Md. : 1950)

Tabi Z,Spary LK,Coleman S,Clayton A,Mason MD,Staffurth J

Thu Jul 15 00:00:00 EDT 2010

The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells from attack by NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Takao S,Ishikawa T,Yamashita K,Uchiyama T

Mon Nov 15 00:00:00 EST 2010

CD8 controls T cell cross-reactivity.

Journal of immunology (Baltimore, Md. : 1950)

Wooldridge L,Laugel B,Ekeruche J,Clement M,van den Berg HA,Price DA,Sewell AK

Fri Oct 15 00:00:00 EDT 2010

Immature NK cells, capable of producing IL-22, are present in human uterine mucosa.

Journal of immunology (Baltimore, Md. : 1950)

Male V,Hughes T,McClory S,Colucci F,Caligiuri MA,Moffett A

Fri Oct 01 00:00:00 EDT 2010

Impact of γ-chain cytokines on EBV-specific T cell cultures.

Journal of translational medicine

Merlo A,Turrini R,Trento C,Zanovello P,Dolcetti R,Rosato A

Mon Nov 22 00:00:00 EST 2010

Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers.

Nature methods

Hadrup SR,Bakker AH,Shu CJ,Andersen RS,van Veluw J,Hombrink P,Castermans E,Thor Straten P,Blank C,Haanen JB,Heemskerk MH,Schumacher TN

Wed Jul 01 00:00:00 EDT 2009

T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells.

Blood

Ahlen MT,Husebekk A,Killie MK,Skogen B,Stuge TB

Thu Apr 16 00:00:00 EDT 2009

Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.

Blood

Woll PS,Grzywacz B,Tian X,Marcus RK,Knorr DA,Verneris MR,Kaufman DS

Thu Jun 11 00:00:00 EDT 2009

Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells.

Blood

Figueiredo C,Wittmann M,Wang D,Dressel R,Seltsam A,Blasczyk R,Eiz-Vesper B

Thu Mar 26 00:00:00 EDT 2009

Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia.

Blood

Rezvani K,Yong AS,Tawab A,Jafarpour B,Eniafe R,Mielke S,Savani BN,Keyvanfar K,Li Y,Kurlander R,Barrett AJ

Thu Mar 05 00:00:00 EST 2009

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.

Blood

Kaneko S,Mastaglio S,Bondanza A,Ponzoni M,Sanvito F,Aldrighetti L,Radrizzani M,La Seta-Catamancio S,Provasi E,Mondino A,Nagasawa T,Fleischhauer K,Russo V,Traversari C,Ciceri F,Bordignon C,Bonini C

Thu Jan 29 00:00:00 EST 2009

Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation.

Blood

Göbel F,Taschner S,Jurkin J,Konradi S,Vaculik C,Richter S,Kneidinger D,Mühlbacher C,Bieglmayer C,Elbe-Bürger A,Strobl H

Thu Oct 29 00:00:00 EDT 2009

Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages.

The Journal of clinical investigation

Song L,Asgharzadeh S,Salo J,Engell K,Wu HW,Sposto R,Ara T,Silverman AM,DeClerck YA,Seeger RC,Metelitsa LS

Mon Jun 01 00:00:00 EDT 2009

Characterization of the class I-restricted gp100 melanoma peptide-stimulated primary immune response in tumor-free vaccine-draining lymph nodes and peripheral blood.

Clinical cancer research : an official journal of the American Association for Cancer Research

Walker EB,Miller W,Haley D,Floyd K,Curti B,Urba WJ

Wed Apr 01 00:00:00 EDT 2009

Impaired STAT phosphorylation in T cells from melanoma patients in response to IL-2: association with clinical stage.

Clinical cancer research : an official journal of the American Association for Cancer Research

Mortarini R,Vegetti C,Molla A,Arienti F,Ravagnani F,Maurichi A,Patuzzo R,Santinami M,Anichini A

Mon Jun 15 00:00:00 EDT 2009

Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes.

Proceedings of the National Academy of Sciences of the United States of America

Yokoyama S,Watanabe N,Sato N,Perera PY,Filkoski L,Tanaka T,Miyasaka M,Waldmann TA,Hiroi T,Perera LP

Tue Sep 15 00:00:00 EDT 2009

Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment.

Proceedings of the National Academy of Sciences of the United States of America

Weiss JM,Back TC,Scarzello AJ,Subleski JJ,Hall VL,Stauffer JK,Chen X,Micic D,Alderson K,Murphy WJ,Wiltrout RH

Tue Nov 17 00:00:00 EST 2009

Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses.

Proceedings of the National Academy of Sciences of the United States of America

Brandes M,Willimann K,Bioley G,Lévy N,Eberl M,Luo M,Tampé R,Lévy F,Romero P,Moser B

Tue Feb 17 00:00:00 EST 2009

IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death.

Cell death and differentiation

Czystowska M,Han J,Szczepanski MJ,Szajnik M,Quadrini K,Brandwein H,Hadden JW,Signorelli K,Whiteside TL

Fri May 01 00:00:00 EDT 2009

High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease.

PLoS pathogens

Enose-Akahata Y,Matsuura E,Oh U,Jacobson S

Tue Dec 01 00:00:00 EST 2009

Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells.

Journal of immunology (Baltimore, Md. : 1950)

Van Coppernolle S,Verstichel G,Timmermans F,Velghe I,Vermijlen D,De Smedt M,Leclercq G,Plum J,Taghon T,Vandekerckhove B,Kerre T

Thu Oct 15 00:00:00 EDT 2009

IL-12-dependent inducible expression of the CD94/NKG2A inhibitory receptor regulates CD94/NKG2C+ NK cell function.

Journal of immunology (Baltimore, Md. : 1950)

Sáez-Borderías A,Romo N,Magri G,Gumá M,Angulo A,López-Botet M

Thu Jan 15 00:00:00 EST 2009

Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Giustiniani J,Bensussan A,Marie-Cardine A

Thu Jan 01 00:00:00 EST 2009

Expansion of functionally skewed CD56-negative NK cells in chronic hepatitis C virus infection: correlation with outcome of pegylated IFN-alpha and ribavirin treatment.

Journal of immunology (Baltimore, Md. : 1950)

Gonzalez VD,Falconer K,Björkström NK,Blom KG,Weiland O,Ljunggren HG,Alaeus A,Sandberg JK

Sun Nov 15 00:00:00 EST 2009

Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptide.

Journal of immunology (Baltimore, Md. : 1950)

Pozo D,Anderson P,Gonzalez-Rey E

Thu Oct 01 00:00:00 EDT 2009

NK cells recognize and kill human glioblastoma cells with stem cell-like properties.

Journal of immunology (Baltimore, Md. : 1950)

Castriconi R,Daga A,Dondero A,Zona G,Poliani PL,Melotti A,Griffero F,Marubbi D,Spaziante R,Bellora F,Moretta L,Moretta A,Corte G,Bottino C

Sun Mar 15 00:00:00 EDT 2009

Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

Journal of immunology (Baltimore, Md. : 1950)

Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B

Sat Aug 01 00:00:00 EDT 2009

RasGRP1 is required for human NK cell function.

Journal of immunology (Baltimore, Md. : 1950)

Lee SH,Yun S,Lee J,Kim MJ,Piao ZH,Jeong M,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I

Tue Dec 15 00:00:00 EST 2009

Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.

Blood

Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA

Sat Nov 01 00:00:00 EDT 2008

The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation.

Blood

Wu Z,Xue HH,Bernard J,Zeng R,Issakov D,Bollenbacher-Reilley J,Belyakov IM,Oh S,Berzofsky JA,Leonard WJ

Mon Dec 01 00:00:00 EST 2008

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

The Journal of clinical investigation

Skowera A,Ellis RJ,Varela-Calviño R,Arif S,Huang GC,Van-Krinks C,Zaremba A,Rackham C,Allen JS,Tree TI,Zhao M,Dayan CM,Sewell AK,Unger WW,Drijfhout JW,Ossendorp F,Roep BO,Peakman M

Wed Oct 01 00:00:00 EDT 2008

Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21.

Clinical cancer research : an official journal of the American Association for Cancer Research

Ansén S,Butler MO,Berezovskaya A,Murray AP,Stevenson K,Nadler LM,Hirano N

Wed Oct 01 00:00:00 EDT 2008

Surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional HPV16-specific T-cell response.

Clinical cancer research : an official journal of the American Association for Cancer Research

de Vos van Steenwijk PJ,Piersma SJ,Welters MJ,van der Hulst JM,Fleuren G,Hellebrekers BW,Kenter GG,van der Burg SH

Sat Nov 15 00:00:00 EST 2008

Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.

Journal of immunology (Baltimore, Md. : 1950)

Kamimura D,Bevan MJ

Wed Oct 15 00:00:00 EDT 2008

Umbilical cord blood T cells express multiple natural cytotoxicity receptors after IL-15 stimulation, but only NKp30 is functional.

Journal of immunology (Baltimore, Md. : 1950)

Tang Q,Grzywacz B,Wang H,Kataria N,Cao Q,Wagner JE,Blazar BR,Miller JS,Verneris MR

Wed Oct 01 00:00:00 EDT 2008

Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.

The Journal of biological chemistry

Lindemann MJ,Hu Z,Benczik M,Liu KD,Gaffen SL

Fri May 16 00:00:00 EDT 2008

Natural killer cells trigger differentiation of monocytes into dendritic cells.

Blood

Zhang AL,Colmenero P,Purath U,Teixeira de Matos C,Hueber W,Klareskog L,Tarner IH,Engleman EG,Söderström K

Mon Oct 01 00:00:00 EDT 2007

Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T

Sat Sep 15 00:00:00 EDT 2007

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.

Proceedings of the National Academy of Sciences of the United States of America

Bauer A,Villunger A,Labi V,Fischer SF,Strasser A,Wagner H,Schmid RM,Häcker G

Tue Jul 18 00:00:00 EDT 2006

Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines.

Journal of immunology (Baltimore, Md. : 1950)

Chiu WK,Fann M,Weng NP

Fri Dec 01 00:00:00 EST 2006

Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines.

Journal of immunology (Baltimore, Md. : 1950)

Chiu WK,Fann M,Weng NP

Fri Dec 01 00:00:00 EST 2006

Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.

The Journal of experimental medicine

Lin L,Gerth AJ,Peng SL

Mon Jul 05 00:00:00 EDT 2004

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

Cancer research

Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT

Sat Feb 15 00:00:00 EST 2003

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice.

Blood

Shimoda K,Tsutsui H,Aoki K,Kato K,Matsuda T,Numata A,Takase K,Yamamoto T,Nukina H,Hoshino T,Asano Y,Gondo H,Okamura T,Okamura S,Nakayama K,Nakanishi K,Niho Y,Harada M

Fri Mar 15 00:00:00 EST 2002

Interleukin-15 is an autocrine/paracrine viability factor for cutaneous T-cell lymphoma cells.

Blood

Döbbeling U,Dummer R,Laine E,Potoczna N,Qin JZ,Burg G

Wed Jul 01 00:00:00 EDT 1998

Interleukin-15 is an autocrine/paracrine viability factor for cutaneous T-cell lymphoma cells.

Blood

Döbbeling U,Dummer R,Laine E,Potoczna N,Qin JZ,Burg G

Wed Jul 01 00:00:00 EDT 1998

Bioinformatics

Protein Aliases: il 15; IL-15; ILN; Interleukin; Interleukin-15; Interleukin15; M-IL-15; MGC9721

Human IL-15 Recombinant Protein, PeproTech®

Human IL-15 Protein (200-15-10UG) in Functional

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200-15-10UG

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