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Product Details
PHC0186
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
Human IL-18, amino acids 37-193
Molecular weight
18 kDa
Class
Recombinant
Type
Protein
Purity
>90% by SDS-PAGE
Endotoxin concentration
<0.1 ng/µg
Activity
Determined by the dose-dependent production of IFN-gamma by human KG-1 myelomonocyte cells.
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS with 0.1% BSA, 1% sucrose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Wet or Dry ice (international)
Product Specific Information
Reconstitution: We recommend the vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute with 250 µL ice cold, sterile, distilled water on ice.
Storage: Store this lyophilized preparation at -20°C, preferably desiccated. Upon reconstitution, the protein may be stored at 2°C to 8°C for up to one week. For long term storage of the reconstituted protein, apportion into working aliquots and store at -80°C. Avoid repeated freeze/thaw cycles.
Target Information
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Iboctadekin; IFN-gamma-inducing factor; il 18; IL-1 gamma; IL-18; ILN; Interferon gamma-inducing factor; Interleukin; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; Interleukin-18; Interleukin18; MGC12320
Gene Aliases: IGIF; IL-18; IL-1g; IL18; IL1F4
UniProt ID: (Human) Q14116
Entrez Gene ID: (Human) 3606
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