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Product Details
BMS334
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
Human IL-2 recombinant protein contains 133 amino acids. It contains and N-terminal Met and a A126C substitution.
Molecular weight
15.4 kDa
Class
Recombinant
Type
Protein
Purity
>99%
Activity
ED50 < 0.0645 ng/mL; determined by dose-dependent stimulation of murine CTLL-2 cells. This corresponds to a specific activity of 1.55x10e7 IU/mg.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
Description: Recombinant human IL-2 produced in E.Coli is a single, non-glycosylated mutein (variant form) of human IL-2 polypeptide chain containing 133 amino acids and having a molecular mass of 15385.79 Dalton. eBioscience's rhIL-2 is Des N-Terminal Met and has an Ala substitute for Cysteine at position 126.
BMS334 is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is < 0.0645 ng/mL, corresponding to a specific activity of 1.55x107 IU/mg.
Purity: >99%.
Molecular Weight: 15.4 kDa.
Target Information
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aldesleukin; H-IL-2; il 2; IL-2; ILN; Interleukin; Interleukin-2; Interleukin2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; M-IL-2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
Gene Aliases: IL-2; IL2; lymphokine; TCGF
UniProt ID: (Human) P60568
Entrez Gene ID: (Human) 3558
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