Product References
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
The Journal of experimental medicine
He Y,Gallman AE,Xie C,Shen Q,Ma J,Wolfreys FD,Sandy M,Arsov T,Wu X,Qin Y,Zhang P,Jiang S,Stanley M,Wu P,Tan J,Ding H,Xue H,Chen W,Xu J,Criswell LA,Nititham J,Adamski M,Kitching AR,Cook MC,Cao L,Shen N,Cyster JG,Vinuesa CG
200-21 was used in Sample Preparation (FC/FACS) to identify germline novel or rare P2RY8 missense variants in lupus kindreds or the related antiphospholipid syndrome, including a de novo" variant in a child with severe nephritis to uncover a role of P2RY8 in immunological tolerance and lupus pathogenesis."
Mon Jan 03 00:00:00 EST 2022
Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.
JID innovations : skin science from molecules to population health
Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH
200-21 was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.
Sat Jan 01 00:00:00 EST 2022
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.
Life science alliance
Schneider MM,Emmenegger M,Xu CK,Condado Morales I,Meisl G,Turelli P,Zografou C,Zimmermann MR,Frey BM,Fiedler S,Denninger V,Jacquat RP,Madrigal L,Ilsley A,Kosmoliaptsis V,Fiegler H,Trono D,Knowles TP,Aguzzi A
Tue Feb 01 00:00:00 EST 2022
Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro.
Frontiers in immunology
SoRelle ED,Reinoso-Vizcaino NM,Horn GQ,Luftig MA
200-21 was used in Sample Preparation (FC/FACS) to study functional characterizations of Epstein-Barr virus (EBV)-induced dynamic phenotypes that mimic B cell immune responses.
Tue Oct 18 00:00:00 EDT 2022
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.
Cell
Sokal A,Chappert P,Barba-Spaeth G,Roeser A,Fourati S,Azzaoui I,Vandenberghe A,Fernandez I,Meola A,Bouvier-Alias M,Crickx E,Beldi-Ferchiou A,Hue S,Languille L,Michel M,Baloul S,Noizat-Pirenne F,Luka M,Mégret J,Ménager M,Pawlotsky JM,Fillatreau S,Rey FA,Weill JC,Reynaud CA,Mahévas M
Thu Mar 04 00:00:00 EST 2021
The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell
Dejnirattisai W,Zhou D,Ginn HM,Duyvesteyn HME,Supasa P,Case JB,Zhao Y,Walter TS,Mentzer AJ,Liu C,Wang B,Paesen GC,Slon-Campos J,López-Camacho C,Kafai NM,Bailey AL,Chen RE,Ying B,Thompson C,Bolton J,Fyfe A,Gupta S,Tan TK,Gilbert-Jaramillo J,James W,Knight M,Carroll MW,Skelly D,Dold C,Peng Y,Levin R,Dong T,Pollard AJ,Knight JC,Klenerman P,Temperton N,Hall DR,Williams MA,Paterson NG,Bertram FKR,Siebert CA,Clare DK,Howe A,Radecke J,Song Y,Townsend AR,Huang KA,Fry EE,Mongkolsapaya J,Diamond MS,Ren J,Stuart DI,Screaton GR
Thu Apr 15 00:00:00 EDT 2021
mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants.
Immunity
Sokal A,Barba-Spaeth G,Fernández I,Broketa M,Azzaoui I,de La Selle A,Vandenberghe A,Fourati S,Roeser A,Meola A,Bouvier-Alias M,Crickx E,Languille L,Michel M,Godeau B,Gallien S,Melica G,Nguyen Y,Zarrouk V,Canoui-Poitrine F,Pirenne F,Mégret J,Pawlotsky JM,Fillatreau S,Bruhns P,Rey FA,Weill JC,Reynaud CA,Chappert P,Mahévas M
Tue Dec 14 00:00:00 EST 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
200-21 was used in Cell Culture to show that Linezolid, a ribosomal-targeting antibiotic (RAbo), effectively blocked the course of a T cell-mediated autoimmune disease.
Tue Jan 12 00:00:00 EST 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
200-21 was used in Cell Culture to show that Linezolid, a ribosomal-targeting antibiotic (RAbo), effectively blocked the course of a T cell-mediated autoimmune disease.
Tue Jan 12 00:00:00 EST 2021
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.
Immunity
Ehx G,Larouche JD,Durette C,Laverdure JP,Hesnard L,Vincent K,Hardy MP,Thériault C,Rulleau C,Lanoix J,Bonneil E,Feghaly A,Apavaloaei A,Noronha N,Laumont CM,Delisle JS,Vago L,Hébert J,Sauvageau G,Lemieux S,Thibault P,Perreault C
Tue Apr 13 00:00:00 EDT 2021
Selenium-GPX4 axis protects follicular helper T cells from ferroptosis.
Nature immunology
Yao Y,Chen Z,Zhang H,Chen C,Zeng M,Yunis J,Wei Y,Wan Y,Wang N,Zhou M,Qiu C,Zeng Q,Ong HS,Wang H,Makota FV,Yang Y,Yang Z,Wang N,Deng J,Shen C,Xia Y,Yuan L,Lian Z,Deng Y,Guo C,Huang A,Zhou P,Shi H,Zhang W,Yi H,Li D,Xia M,Fu J,Wu N,de Haan JB,Shen N,Zhang W,Liu Z,Yu D
Wed Sep 01 00:00:00 EDT 2021
Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus.
The Journal of clinical investigation
Vlahava VM,Murrell I,Zhuang L,Aicheler RJ,Lim E,Miners KL,Ladell K,Suárez NM,Price DA,Davison AJ,Wilkinson GW,Wills MR,Weekes MP,Wang EC,Stanton RJ
Mon Feb 15 00:00:00 EST 2021
Seasonal coronavirus-specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19.
The Journal of clinical investigation
Aguilar-Bretones M,Westerhuis BM,Raadsen MP,de Bruin E,Chandler FD,Okba NM,Haagmans BL,Langerak T,Endeman H,van den Akker JP,Gommers DA,van Gorp EC,GeurtsvanKessel CH,de Vries RD,Fouchier RA,Rockx BH,Koopmans MP,van Nierop GP
Mon Nov 01 00:00:00 EDT 2021
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Molecular cell
Gong C,Krupka JA,Gao J,Grigoropoulos NF,Giotopoulos G,Asby R,Screen M,Usheva Z,Cucco F,Barrans S,Painter D,Zaini NBM,Haupl B,Bornelöv S,Ruiz De Los Mozos I,Meng W,Zhou P,Blain AE,Forde S,Matthews J,Khim Tan MG,Burke GAA,Sze SK,Beer P,Burton C,Campbell P,Rand V,Turner SD,Ule J,Roman E,Tooze R,Oellerich T,Huntly BJ,Turner M,Du MQ,Samarajiwa SA,Hodson DJ
Thu Oct 07 00:00:00 EDT 2021
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Molecular cell
Gong C,Krupka JA,Gao J,Grigoropoulos NF,Giotopoulos G,Asby R,Screen M,Usheva Z,Cucco F,Barrans S,Painter D,Zaini NBM,Haupl B,Bornelöv S,Ruiz De Los Mozos I,Meng W,Zhou P,Blain AE,Forde S,Matthews J,Khim Tan MG,Burke GAA,Sze SK,Beer P,Burton C,Campbell P,Rand V,Turner SD,Ule J,Roman E,Tooze R,Oellerich T,Huntly BJ,Turner M,Du MQ,Samarajiwa SA,Hodson DJ
Thu Oct 07 00:00:00 EDT 2021
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.
The Journal of experimental medicine
Pieters T,T'Sas S,Vanhee S,Almeida A,Driege Y,Roels J,Van Loocke W,Daneels W,Baens M,Marchand A,Van Trimpont M,Matthijssens F,Morscio J,Lemeire K,Lintermans B,Reunes L,Chaltin P,Offner F,Van Dorpe J,Hochepied T,Berx G,Beyaert R,Staal J,Van Vlierberghe P,Goossens S
Mon Oct 04 00:00:00 EDT 2021
T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients.
The Journal of experimental medicine
Kuehn HS,Chang J,Yamashita M,Niemela JE,Zou C,Okuyama K,Harada J,Stoddard JL,Nunes-Santos CJ,Boast B,Baxter RM,Hsieh EWY,Garofalo M,Fleisher TA,Morio T,Taniuchi I,Dutmer CM,Rosenzweig SD
Mon Dec 06 00:00:00 EST 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 EST 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 EST 2021
Conserved Epigenetic Programming and Enhanced Heme Metabolism Drive Memory B Cell Reactivation.
Journal of immunology (Baltimore, Md. : 1950)
Price MJ,Scharer CD,Kania AK,Randall TD,Boss JM
Thu Apr 01 00:00:00 EDT 2021
CD40L-Stimulated B Lymphocytes Are Polarized toward APC Functions after Exposure to IL-4 and IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Possamaï D,Pagé G,Panès R,Gagnon É,Lapointe R
Thu Jul 01 00:00:00 EDT 2021
Peripheral leukemia burden at time of apheresis negatively affects the clinical efficacy of CART19 in refractory or relapsed B-ALL.
Molecular therapy. Methods & clinical development
Deng B,Pan J,Liu Z,Liu S,Chen Y,Qu X,Zhang Y,Lin Y,Zhang Y,Yu X,Zhang Z,Niu X,Luan R,Ma M,Li X,Liu T,Wu X,Niu H,Chang AH,Tong C
Fri Dec 10 00:00:00 EST 2021
The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses.
Nature communications
Deng J,Chen Q,Chen Z,Liang K,Gao X,Wang X,Makota FV,Ong HS,Wan Y,Luo K,Gong D,Yu X,Camuglia S,Zeng Q,Zhou T,Xue F,He J,Wei Y,Xiao F,Ma J,Hill DL,Pierson W,Nguyen THO,Zhou H,Wang Y,Shen W,Sun L,Li Z,Xia Q,Qian K,Ye L,Rockman S,Linterman MA,Kedzierska K,Shen N,Lu L,Yu D
Mon May 24 00:00:00 EDT 2021
Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder.
eLife
Wu B,Rice L,Shrimpton J,Lawless D,Walker K,Carter C,McKeown L,Anwar R,Doody GM,Srikanth S,Gwack Y,Savic S
200-21 was used in Cell Culture to identify variants in CRACR2A that led to late-stage combined immunodeficiency characterized by loss of function in T cells.
Wed Dec 15 00:00:00 EST 2021
Pattern of circulating SARS-CoV-2-specific antibody-secreting and memory B-cell generation in patients with acute COVID-19.
Clinical & translational immunology
Byazrova M,Yusubalieva G,Spiridonova A,Efimov G,Mazurov D,Baranov K,Baklaushev V,Filatov A
Wed Apr 20 00:00:00 EDT 2022
Pseurotin D Inhibits the Activation of Human Lymphocytes.
International journal of molecular sciences
Rubanova D,Dadova P,Vasicek O,Kubala L
200-21 was used in Cell Culture to perform complex characterization of the effects of pseurotin D on human lymphocyte activation to understand the potential of pseurotin to modulate immune response in humans.
Tue Feb 16 00:00:00 EST 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 EDT 2021
Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity.
Cell reports
Szodoray P,Andersen TK,Heinzelbecker J,Imbery JF,Huszthy PC,Stanford SM,Bogen B,Landsverk OB,Bottini N,Tveita A,Munthe LA,Nakken B
Tue Aug 10 00:00:00 EDT 2021
Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.
Cell reports
Zebley CC,Abdelsamed HA,Ghoneim HE,Alli S,Brown C,Haydar D,Mi T,Harris T,McGargill MA,Krenciute G,Youngblood B
Tue Oct 12 00:00:00 EDT 2021
Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer.
STAR protocols
Rotolo A,Atherton MJ,Kasper BT,Haran KP,Mason NJ
200-21 was used in In vitro experiments to optimize a retrovirus-based protocol to efficiently CAR transduce primary T cells from healthy and tumor-bearing dogs.
Fri Dec 17 00:00:00 EST 2021
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses.
Cell reports. Medicine
Mandolesi M,Sheward DJ,Hanke L,Ma J,Pushparaj P,Perez Vidakovics L,Kim C,Àdori M,Lenart K,Loré K,Castro Dopico X,Coquet JM,McInerney GM,Karlsson Hedestam GB,Murrell B
Tue Apr 20 00:00:00 EDT 2021
Generation of glucocorticoid-resistant SARS-CoV-2 T cells for adoptive cell therapy.
Cell reports
Basar R,Uprety N,Ensley E,Daher M,Klein K,Martinez F,Aung F,Shanley M,Hu B,Gokdemir E,Nunez Cortes AK,Mendt M,Reyes Silva F,Acharya S,Laskowski T,Muniz-Feliciano L,Banerjee PP,Li Y,Li S,Melo Garcia L,Lin P,Shaim H,Yates SG,Marin D,Kaur I,Rao S,Mak D,Lin A,Miao Q,Dou J,Chen K,Champlin RE,Shpall EJ,Rezvani K
Tue Jul 20 00:00:00 EDT 2021
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Blood
Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE
Thu Aug 06 00:00:00 EDT 2020
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
The Journal of clinical investigation
Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q
Wed Jul 01 00:00:00 EDT 2020
Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome.
The Journal of experimental medicine
Helfricht A,Thijssen PE,Rother MB,Shah RG,Du L,Takada S,Rogier M,Moritz J,IJspeert H,Stoepker C,van Ostaijen-Ten Dam MM,Heyer V,Luijsterburg MS,de Groot A,Jak R,Grootaers G,Wang J,Rao P,Vertegaal ACO,van Tol MJD,Pan-Hammarström Q,Reina-San-Martin B,Shah GM,van der Burg M,van der Maarel SM,van Attikum H
Mon Nov 02 00:00:00 EST 2020
Histone Deacetylase Inhibitors and IL21 Cooperate to Reprogram Human Effector CD8+ T Cells to Memory T Cells.
Cancer immunology research
Wang J,Hasan F,Frey AC,Li HS,Park J,Pan K,Haymaker C,Bernatchez C,Lee DA,Watowich SS,Yee C
200-21 was used in In vitro experiments to support the application of IL21 and HDACi for the in vitro generation of highly persistent T-cell populations that can augment the efficacy of adoptively transferred T cells.
Mon Jun 01 00:00:00 EDT 2020
mTOR sustains inflammatory response in celiac disease.
Scientific reports
Sedda S,Dinallo V,Marafini I,Franzè E,Paoluzi OA,Izzo R,Giuffrida P,Di Sabatino A,Corazza GR,Monteleone G
Wed Jul 01 00:00:00 EDT 2020
Stimulation of B Cell Immunity in Flavivirus-Naive Individuals by the Tetravalent Live Attenuated Dengue Vaccine TV003.
Cell reports. Medicine
Tu HA,Nivarthi UK,Graham NR,Eisenhauer P,Delacruz MJ,Pierce KK,Whitehead SS,Boyson JE,Botten JW,Kirkpatrick BD,Durbin AP,deSilva AM,Diehl SA
200-21 was used in Cell Culture to investigate immune response to live-attenuated vaccine TV003.
Tue Dec 22 00:00:00 EST 2020
Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.
Nature communications
Evans RDR,Antonelou M,Sathiananthamoorthy S,Rega M,Henderson S,Ceron-Gutierrez L,Barcenas-Morales G,Müller CA,Doffinger R,Walsh SB,Salama AD
Mon Aug 31 00:00:00 EDT 2020
IL-21 Stimulates the expression and activation of cell cycle regulators and promotes cell proliferation in EBV-positive diffuse large B cell lymphoma.
Scientific reports
Wang Y,Wang C,Cai X,Mou C,Cui X,Zhang Y,Ge F,Dong H,Hao Y,Cai L,Wu S,Feng C,Chen J,Li J,Xu W,Fan L,Xie W,Tong Y,Gu HF,Wu L
Thu Jul 23 00:00:00 EDT 2020
IL-21 Stimulates the expression and activation of cell cycle regulators and promotes cell proliferation in EBV-positive diffuse large B cell lymphoma.
Scientific reports
Wang Y,Wang C,Cai X,Mou C,Cui X,Zhang Y,Ge F,Dong H,Hao Y,Cai L,Wu S,Feng C,Chen J,Li J,Xu W,Fan L,Xie W,Tong Y,Gu HF,Wu L
Thu Jul 23 00:00:00 EDT 2020
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma.
Nature communications
Mitra A,Andrews MC,Roh W,De Macedo MP,Hudgens CW,Carapeto F,Singh S,Reuben A,Wang F,Mao X,Song X,Wani K,Tippen S,Ng KS,Schalck A,Sakellariou-Thompson DA,Chen E,Reddy SM,Spencer CN,Wiesnoski D,Little LD,Gumbs C,Cooper ZA,Burton EM,Hwu P,Davies MA,Zhang J,Bernatchez C,Navin N,Sharma P,Allison JP,Wargo JA,Yee C,Tetzlaff MT,Hwu WJ,Lazar AJ,Futreal PA
Wed Apr 15 00:00:00 EDT 2020
Intact B-Cell Signaling and Function With Host B-Cells 47 Years After Transplantation for X-SCID.
Frontiers in immunology
Deal C,Thauland TJ,Stiehm ER,Garcia-Lloret MI,Butte MJ
200-21 was used in Sample Preparation (FC/FACS) to demonstrate that satisfactory B-cell function can arise as a consequence of both intact IL-21 signaling due to a hypomorphic γc variant, and close HLA matching with the donor to allow for effective T-cell help.
Mon Mar 08 00:00:00 EST 2021
Selective dysregulation of ROCK2 activity promotes aberrant transcriptional networks in ABC diffuse large B-cell lymphoma.
Scientific reports
Ricker E,Verma A,Marullo R,Gupta S,Ye C,Pannellini T,Manni M,Tam W,Inghirami G,Elemento O,Cerchietti L,Pernis AB
Tue Aug 04 00:00:00 EDT 2020
Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection.
Cell
Davis CW,Jackson KJL,McElroy AK,Halfmann P,Huang J,Chennareddy C,Piper AE,Leung Y,Albariño CG,Crozier I,Ellebedy AH,Sidney J,Sette A,Yu T,Nielsen SCA,Goff AJ,Spiropoulou CF,Saphire EO,Cavet G,Kawaoka Y,Mehta AK,Glass PJ,Boyd SD,Ahmed R
Thu May 30 00:00:00 EDT 2019
Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.
Cell
Watanabe A,McCarthy KR,Kuraoka M,Schmidt AG,Adachi Y,Onodera T,Tonouchi K,Caradonna TM,Bajic G,Song S,McGee CE,Sempowski GD,Feng F,Urick P,Kepler TB,Takahashi Y,Harrison SC,Kelsoe G
Thu May 16 00:00:00 EDT 2019
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.
Immunity
Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B
Tue May 21 00:00:00 EDT 2019
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.
Immunity
Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B
Tue May 21 00:00:00 EDT 2019
Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.
The Journal of experimental medicine
Spencer S,Köstel Bal S,Egner W,Lango Allen H,Raza SI,Ma CA,Gürel M,Zhang Y,Sun G,Sabroe RA,Greene D,Rae W,Shahin T,Kania K,Ardy RC,Thian M,Staples E,Pecchia-Bekkum A,Worrall WPM,Stephens J,Brown M,Tuna S,York M,Shackley F,Kerrin D,Sargur R,Condliffe A,Tipu HN,Kuehn HS,Rosenzweig SD,Turro E,Tavaré S,Thrasher AJ,Jodrell DI,Smith KGC,Boztug K,Milner JD,Thaventhiran JED
Mon Sep 02 00:00:00 EDT 2019
Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity.
Experimental & molecular medicine
Kim DH,Park HJ,Park HS,Lee JU,Ko C,Gye MC,Choi JM
Mon Apr 15 00:00:00 EDT 2019
Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.
Journal of immunology (Baltimore, Md. : 1950)
Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM
Fri Feb 15 00:00:00 EST 2019
Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses.
Journal of immunology (Baltimore, Md. : 1950)
Onodera T,Hashi K,Shukla RK,Miki M,Takai-Todaka R,Fujimoto A,Kuraoka M,Miyoshi T,Kobayashi K,Hasegawa H,Ato M,Kelsoe G,Katayama K,Takahashi Y
Sun Dec 15 00:00:00 EST 2019
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.
Nature communications
Fan J,Liang H,Ji X,Wang S,Xue J,Li D,Peng H,Qin C,Yee C,Shao Y
Tue May 21 00:00:00 EDT 2019
Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC.
Frontiers in immunology
Oda H,Beck DB,Kuehn HS,Sampaio Moura N,Hoffmann P,Ibarra M,Stoddard J,Tsai WL,Gutierrez-Cruz G,Gadina M,Rosenzweig SD,Kastner DL,Notarangelo LD,Aksentijevich I
200-21 was used in In vitro experiments to identify a genetic cause of a disease for an 8 year-old girl who presented with early-onset immune deficiency and autoinflammation.
Thu Sep 10 00:00:00 EDT 2020
Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition.
Pharmacology research & perspectives
Dowty ME,Lin TH,Jesson MI,Hegen M,Martin DA,Katkade V,Menon S,Telliez JB
200-21 was used in In vitro experiments to determine JAK-dependent cytokine receptor inhibition profiles, in the context of doses estimated to provide a similar clinical response in RA clinical trials.
Sun Dec 01 00:00:00 EST 2019
Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer.
Cells
Linnebacher A,Mayer P,Marnet N,Bergmann F,Herpel E,Revia S,Yin L,Liu L,Hackert T,Giese T,Herr I,Gaida MM
200-21 was used in Sample Preparation (Western Blotting) to show an association of IL-21+ immune cell infiltration and IL-21 receptor expression in PDAC with poor survival, most likely due to an IL-21-mediated promotion of tumor cell invasion and enhanced colony formation, supporting the notion of the tumor-promoting abilities of the tumor microenvironment.
Wed Sep 18 00:00:00 EDT 2019
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.
Nature communications
Adachi Y,Tonouchi K,Nithichanon A,Kuraoka M,Watanabe A,Shinnakasu R,Asanuma H,Ainai A,Ohmi Y,Yamamoto T,Ishii KJ,Hasegawa H,Takeyama H,Lertmemongkolchai G,Kurosaki T,Ato M,Kelsoe G,Takahashi Y
Wed Aug 28 00:00:00 EDT 2019
IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation.
eLife
Zumaquero E,Stone SL,Scharer CD,Jenks SA,Nellore A,Mousseau B,Rosal-Vela A,Botta D,Bradley JE,Wojciechowski W,Ptacek T,Danila MI,Edberg JC,Bridges SL,Kimberly RP,Chatham WW,Schoeb TR,Rosenberg AF,Boss JM,Sanz I,Lund FE
200-21 was used in In vitro experiments to investigate the role of IFNγ signaling in human antibody responses in Systemic Lupus Erythematosus.
Wed May 15 00:00:00 EDT 2019
Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.
Immunity
McCarthy KR,Watanabe A,Kuraoka M,Do KT,McGee CE,Sempowski GD,Kepler TB,Schmidt AG,Kelsoe G,Harrison SC
Tue Jan 16 00:00:00 EST 2018
Spatial distribution and function of T follicular regulatory cells in human lymph nodes.
The Journal of experimental medicine
Sayin I,Radtke AJ,Vella LA,Jin W,Wherry EJ,Buggert M,Betts MR,Herati RS,Germain RN,Canaday DH
Mon Jun 04 00:00:00 EDT 2018
Germline-activating mutations in PIK3CD compromise B cell development and function.
The Journal of experimental medicine
Avery DT,Kane A,Nguyen T,Lau A,Nguyen A,Lenthall H,Payne K,Shi W,Brigden H,French E,Bier J,Hermes JR,Zahra D,Sewell WA,Butt D,Elliott M,Boztug K,Meyts I,Choo S,Hsu P,Wong M,Berglund LJ,Gray P,O'Sullivan M,Cole T,Holland SM,Ma CS,Burkhart C,Corcoran LM,Phan TG,Brink R,Uzel G,Deenick EK,Tangye SG
Mon Aug 06 00:00:00 EDT 2018
Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.
Frontiers in immunology
Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M
200-21 was used in Sample Preparation (FC/FACS) to compare the efficacy of dendritic cell receptor-ligand blockades at various immune checkpoints on T cell activation, an suggest targets for enhanced immunotherapy.
Mon Apr 08 00:00:00 EDT 2019
Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia.
Blood advances
Jalali S,Price-Troska T,Paludo J,Villasboas J,Kim HJ,Yang ZZ,Novak AJ,Ansell SM
Tue Aug 14 00:00:00 EDT 2018
IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Ngai H,Tian G,Courtney AN,Ravari SB,Guo L,Liu B,Jin J,Shen ET,Di Pierro EJ,Metelitsa LS
Mon Oct 01 00:00:00 EDT 2018
Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion.
Nature communications
Nguyen DC,Garimalla S,Xiao H,Kyu S,Albizua I,Galipeau J,Chiang KY,Waller EK,Wu R,Gibson G,Roberson J,Lund FE,Randall TD,Sanz I,Lee FE
Wed Sep 12 00:00:00 EDT 2018
Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity.
Scientific reports
Al-Maskari M,Care MA,Robinson E,Cocco M,Tooze RM,Doody GM
Tue Sep 25 00:00:00 EDT 2018
CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.
Immunity
Suan D,Kräutler NJ,Maag JLV,Butt D,Bourne K,Hermes JR,Avery DT,Young C,Statham A,Elliott M,Dinger ME,Basten A,Tangye SG,Brink R
Tue Dec 19 00:00:00 EST 2017
Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals.
Immunity
Magri G,Comerma L,Pybus M,Sintes J,Lligé D,Segura-Garzón D,Bascones S,Yeste A,Grasset EK,Gutzeit C,Uzzan M,Ramanujam M,van Zelm MC,Albero-González R,Vazquez I,Iglesias M,Serrano S,Márquez L,Mercade E,Mehandru S,Cerutti A
Tue Jul 18 00:00:00 EDT 2017
PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients.
The Journal of experimental medicine
Zhang Y,Ma CA,Lawrence MG,Break TJ,O'Connell MP,Lyons JJ,López DB,Barber JS,Zhao Y,Barber DL,Freeman AF,Holland SM,Lionakis MS,Milner JD
Mon Sep 04 00:00:00 EDT 2017
A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.
The Journal of experimental medicine
Schwerd T,Twigg SRF,Aschenbrenner D,Manrique S,Miller KA,Taylor IB,Capitani M,McGowan SJ,Sweeney E,Weber A,Chen L,Bowness P,Riordan A,Cant A,Freeman AF,Milner JD,Holland SM,Frede N,Müller M,Schmidt-Arras D,Grimbacher B,Wall SA,Jones EY,Wilkie AOM,Uhlig HH
Mon Sep 04 00:00:00 EDT 2017
B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation.
Frontiers in immunology
De S,Zhang B,Shih T,Singh S,Winkler A,Donnelly R,Barnes BJ
200-21 was used in Cell Culture to identify IRF5 as an early regulator of human B cell activation and map IRF5 dysfunction in systemic lupus erythematosus.
Fri Sep 18 00:00:00 EDT 2020
Early Emergence of CD19-Negative Human Antibody-Secreting Cells at the Plasmablast to Plasma Cell Transition.
Journal of immunology (Baltimore, Md. : 1950)
Arumugakani G,Stephenson SJ,Newton DJ,Rawstron A,Emery P,Doody GM,McGonagle D,Tooze RM
Thu Jun 15 00:00:00 EDT 2017
Human Basophils Modulate Plasma Cell Differentiation and Maturation.
Journal of immunology (Baltimore, Md. : 1950)
Dijkstra D,Meyer-Bahlburg A
Sun Jan 01 00:00:00 EST 2017
TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1.
Journal of immunology (Baltimore, Md. : 1950)
Sabins NC,Chornoguz O,Leander K,Kaplan F,Carter R,Kinder M,Bachman K,Verona R,Shen S,Bhargava V,Santulli-Marotto S
Fri Dec 15 00:00:00 EST 2017
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.
Nature communications
Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A
Mon Oct 09 00:00:00 EDT 2017
Epistatic interactions between mutations of TACI (TNFRSF13B) and TCF3 result in a severe primary immunodeficiency disorder and systemic lupus erythematosus.
Clinical & translational immunology
Ameratunga R,Koopmans W,Woon ST,Leung E,Lehnert K,Slade CA,Tempany JC,Enders A,Steele R,Browett P,Hodgkin PD,Bryant VL
Sun Oct 01 00:00:00 EDT 2017
Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome.
Blood
Hubbard N,Hagin D,Sommer K,Song Y,Khan I,Clough C,Ochs HD,Rawlings DJ,Scharenberg AM,Torgerson TR
Thu May 26 00:00:00 EDT 2016
IL-4 rescues surface IgM expression in chronic lymphocytic leukemia.
Blood
Guo B,Zhang L,Chiorazzi N,Rothstein TL
Thu Jul 28 00:00:00 EDT 2016
Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.
The Journal of clinical investigation
Cantaert T,Schickel JN,Bannock JM,Ng YS,Massad C,Delmotte FR,Yamakawa N,Glauzy S,Chamberlain N,Kinnunen T,Menard L,Lavoie A,Walter JE,Notarangelo LD,Bruneau J,Al-Herz W,Kilic SS,Ochs HD,Cunningham-Rundles C,van der Burg M,Kuijpers TW,Kracker S,Kaneko H,Sekinaka Y,Nonoyama S,Durandy A,Meffre E
Tue Nov 01 00:00:00 EDT 2016
Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.
The Journal of experimental medicine
Wang Y,Ma CS,Ling Y,Bousfiha A,Camcioglu Y,Jacquot S,Payne K,Crestani E,Roncagalli R,Belkadi A,Kerner G,Lorenzo L,Deswarte C,Chrabieh M,Patin E,Vincent QB,Müller-Fleckenstein I,Fleckenstein B,Ailal F,Quintana-Murci L,Fraitag S,Alyanakian MA,Leruez-Ville M,Picard C,Puel A,Bustamante J,Boisson-Dupuis S,Malissen M,Malissen B,Abel L,Hovnanian A,Notarangelo LD,Jouanguy E,Tangye SG,Béziat V,Casanova JL
Mon Oct 17 00:00:00 EDT 2016
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.
The Journal of experimental medicine
Ma CS,Wong N,Rao G,Nguyen A,Avery DT,Payne K,Torpy J,O'Young P,Deenick E,Bustamante J,Puel A,Okada S,Kobayashi M,Martinez-Barricarte R,Elliott M,Sebnem Kilic S,El Baghdadi J,Minegishi Y,Bousfiha A,Robertson N,Hambleton S,Arkwright PD,French M,Blincoe AK,Hsu P,Campbell DE,Stormon MO,Wong M,Adelstein S,Fulcher DA,Cook MC,Stepensky P,Boztug K,Beier R,Ikincioğullari A,Ziegler JB,Gray P,Picard C,Boisson-Dupuis S,Phan TG,Grimbacher B,Warnatz K,Holland SM,Uzel G,Casanova JL,Tangye SG
Mon Jul 25 00:00:00 EDT 2016
miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Serr I,Fürst RW,Ott VB,Scherm MG,Nikolaev A,Gökmen F,Kälin S,Zillmer S,Bunk M,Weigmann B,Kunschke N,Loretz B,Lehr CM,Kirchner B,Haase B,Pfaffl M,Waisman A,Willis RA,Ziegler AG,Daniel C
Tue Oct 25 00:00:00 EDT 2016
Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.
Proceedings of the National Academy of Sciences of the United States of America
DeKosky BJ,Lungu OI,Park D,Johnson EL,Charab W,Chrysostomou C,Kuroda D,Ellington AD,Ippolito GC,Gray JJ,Georgiou G
Tue May 10 00:00:00 EDT 2016
Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Care MA,Stephenson SJ,Barnes NA,Fan I,Zougman A,El-Sherbiny YM,Vital EM,Westhead DR,Tooze RM,Doody GM
Mon Aug 15 00:00:00 EDT 2016
Efficient Culture of Human Naive and Memory B Cells for Use as APCs.
Journal of immunology (Baltimore, Md. : 1950)
Su KY,Watanabe A,Yeh CH,Kelsoe G,Kuraoka M
Tue Nov 15 00:00:00 EST 2016
IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice.
Journal of immunology (Baltimore, Md. : 1950)
Vijayan D,Mohd Redzwan N,Avery DT,Wirasinha RC,Brink R,Walters G,Adelstein S,Kobayashi M,Gray P,Elliott M,Wong M,King C,Vinuesa CG,Ghilardi N,Ma CS,Tangye SG,Batten M
Sat Oct 15 00:00:00 EDT 2016
Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis.
Journal of immunology (Baltimore, Md. : 1950)
Zhang CJ,Gong Y,Zhu W,Qi Y,Yang CS,Fu Y,Chang G,Li Y,Shi S,Wood K,Ladha S,Shi FD,Liu Q,Yan Y
Sat Oct 01 00:00:00 EDT 2016
ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.
Journal of immunology (Baltimore, Md. : 1950)
Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V
Sat Oct 01 00:00:00 EDT 2016
Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4(+) T cells, and disease activity.
Scientific reports
Nagafuchi Y,Shoda H,Sumitomo S,Nakachi S,Kato R,Tsuchida Y,Tsuchiya H,Sakurai K,Hanata N,Tateishi S,Kanda H,Ishigaki K,Okada Y,Suzuki A,Kochi Y,Fujio K,Yamamoto K
Thu Jul 07 00:00:00 EDT 2016
Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Nature communications
Serr I,Fürst RW,Achenbach P,Scherm MG,Gökmen F,Haupt F,Sedlmeier EM,Knopff A,Shultz L,Willis RA,Ziegler AG,Daniel C
Tue Mar 15 00:00:00 EDT 2016
Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma.
Nature communications
Ouyang FZ,Wu RQ,Wei Y,Liu RX,Yang D,Xiao X,Zheng L,Li B,Lao XM,Kuang DM
Thu Nov 17 00:00:00 EST 2016
CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.
Scientific reports
Dimitrova M,Zenarruzabeitia O,Borrego F,Simhadri VR
Mon Apr 04 00:00:00 EDT 2016
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Nature communications
Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM
Mon Nov 21 00:00:00 EST 2016
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
Nature medicine
Ortega-Molina A,Boss IW,Canela A,Pan H,Jiang Y,Zhao C,Jiang M,Hu D,Agirre X,Niesvizky I,Lee JE,Chen HT,Ennishi D,Scott DW,Mottok A,Hother C,Liu S,Cao XJ,Tam W,Shaknovich R,Garcia BA,Gascoyne RD,Ge K,Shilatifard A,Elemento O,Nussenzweig A,Melnick AM,Wendel HG
200-21 was used in Cell Culture to show that KMT2D mutations may promote malignant outgrowth by perturbing the expression of genes that control B cell-activating pathways.
Thu Oct 01 00:00:00 EDT 2015
Differential induction of plasma cells by isoforms of human TACI.
Blood
Garcia-Carmona Y,Cols M,Ting AT,Radigan L,Yuk FJ,Zhang L,Cerutti A,Cunningham-Rundles C
Thu Mar 12 00:00:00 EDT 2015
Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients.
Cellular & molecular immunology
Xu X,Shang Q,Chen X,Nie W,Zou Z,Huang A,Meng M,Jin L,Xu R,Zhang JY,Fu J,Wang L,Tang Z,Xie Y,Yang X,Zhang Z,Wang FS
Fri May 01 00:00:00 EDT 2015
Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.
Proceedings of the National Academy of Sciences of the United States of America
Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X
Tue Dec 29 00:00:00 EST 2015
Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ramos-Amaya A,Rodríguez-Bayona B,López-Blanco R,Andújar E,Pérez-Alegre M,Campos-Caro A,Brieva JA
Sun Feb 01 00:00:00 EST 2015
Cutting edge: circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production.
Journal of immunology (Baltimore, Md. : 1950)
Chavele KM,Merry E,Ehrenstein MR
Sun Mar 15 00:00:00 EDT 2015
Human IL-21+IFN-γ+CD4+ T cells in nasal polyps are regulated by IL-12.
Scientific reports
Xiao L,Jia L,Zhang Y,Yu S,Wu X,Yang B,Li H,Wu C
Tue Aug 04 00:00:00 EDT 2015
Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.
Blood
Zhu S,Phatarpekar PV,Denman CJ,Senyukov VV,Somanchi SS,Nguyen-Jackson HT,Mace EM,Freeman AF,Watowich SS,Orange JS,Holland SM,Lee DA
Thu Jul 17 00:00:00 EDT 2014
Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.
The Journal of clinical investigation
Jandus C,Boligan KF,Chijioke O,Liu H,Dahlhaus M,Démoulins T,Schneider C,Wehrli M,Hunger RE,Baerlocher GM,Simon HU,Romero P,Münz C,von Gunten S
Tue Apr 01 00:00:00 EDT 2014
Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia.
Journal of immunology (Baltimore, Md. : 1950)
Gordon SN,Doster MN,Kines RC,Keele BF,Brocca-Cofano E,Guan Y,Pegu P,Liyanage NP,Vaccari M,Cuburu N,Buck CB,Ferrari G,Montefiori D,Piatak M,Lifson JD,Xenophontos AM,Venzon D,Robert-Guroff M,Graham BS,Lowy DR,Schiller JT,Franchini G
Mon Dec 15 00:00:00 EST 2014
CD19 and CD32b differentially regulate human B cell responsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Karnell JL,Dimasi N,Karnell FG,Fleming R,Kuta E,Wilson M,Wu H,Gao C,Herbst R,Ettinger R
Sat Feb 15 00:00:00 EST 2014
Autoantibodies induced by chimeric cytokine-HIV envelope glycoprotein immunogens.
Journal of immunology (Baltimore, Md. : 1950)
Isik G,van Montfort T,Chung NP,Moore JP,Sanders RW
Thu May 15 00:00:00 EDT 2014
Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.
Blood
Wölfl M,Schwinn S,Yoo YE,Reß ML,Braun M,Chopra M,Schreiber SC,Ayala VI,Ohlen C,Eyrich M,Beilhack A,Schlegel PG
Thu Aug 15 00:00:00 EDT 2013
IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.
Blood
Berglund LJ,Avery DT,Ma CS,Moens L,Deenick EK,Bustamante J,Boisson-Dupuis S,Wong M,Adelstein S,Arkwright PD,Bacchetta R,Bezrodnik L,Dadi H,Roifman CM,Fulcher DA,Ziegler JB,Smart JM,Kobayashi M,Picard C,Durandy A,Cook MC,Casanova JL,Uzel G,Tangye SG
Thu Dec 05 00:00:00 EST 2013
Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.
The Journal of experimental medicine
Byun M,Ma CS,Akçay A,Pedergnana V,Palendira U,Myoung J,Avery DT,Liu Y,Abhyankar A,Lorenzo L,Schmidt M,Lim HK,Cassar O,Migaud M,Rozenberg F,Canpolat N,Aydogan G,Fleckenstein B,Bustamante J,Picard C,Gessain A,Jouanguy E,Cesarman E,Olivier M,Gros P,Abel L,Croft M,Tangye SG,Casanova JL
Mon Aug 26 00:00:00 EDT 2013
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome.
The Journal of experimental medicine
Kotlarz D,Ziętara N,Uzel G,Weidemann T,Braun CJ,Diestelhorst J,Krawitz PM,Robinson PN,Hecht J,Puchałka J,Gertz EM,Schäffer AA,Lawrence MG,Kardava L,Pfeifer D,Baumann U,Pfister ED,Hanson EP,Schambach A,Jacobs R,Kreipe H,Moir S,Milner JD,Schwille P,Mundlos S,Klein C
Mon Mar 11 00:00:00 EDT 2013
STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.
Journal of immunology (Baltimore, Md. : 1950)
Rodríguez-Bayona B,Ramos-Amaya A,López-Blanco R,Campos-Caro A,Brieva JA
Fri Nov 15 00:00:00 EST 2013
IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.
Journal of immunology (Baltimore, Md. : 1950)
Ding BB,Bi E,Chen H,Yu JJ,Ye BH
Fri Feb 15 00:00:00 EST 2013
IL-21 enhances phagocytosis in mononuclear phagocyte cells: identification of spleen tyrosine kinase as a novel molecular target of IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Vallières F,Girard D
Fri Mar 15 00:00:00 EDT 2013
TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.
PloS one
Liu Y,Yu S,Li Z,Ma J,Zhang Y,Wang H,Yang B,Wu C
Tue Feb 18 00:00:00 EST 2014
IRX-2, a novel immunotherapeutic, enhances functions of human dendritic cells.
PloS one
Schilling B,Harasymczuk M,Schuler P,Egan J,Ferrone S,Whiteside TL
Fri Sep 06 00:00:00 EDT 2013
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.
Blood
Hodge LS,Ziesmer SC,Yang ZZ,Secreto FJ,Gertz MA,Novak AJ,Ansell SM
Thu Nov 01 00:00:00 EDT 2012
Functional STAT3 deficiency compromises the generation of human T follicular helper cells.
Blood
Ma CS,Avery DT,Chan A,Batten M,Bustamante J,Boisson-Dupuis S,Arkwright PD,Kreins AY,Averbuch D,Engelhard D,Magdorf K,Kilic SS,Minegishi Y,Nonoyama S,French MA,Choo S,Smart JM,Peake J,Wong M,Gray P,Cook MC,Fulcher DA,Casanova JL,Deenick EK,Tangye SG
Thu Apr 26 00:00:00 EDT 2012
Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen.
Blood
Ochsenreither S,Majeti R,Schmitt T,Stirewalt D,Keilholz U,Loeb KR,Wood B,Choi YE,Bleakley M,Warren EH,Hudecek M,Akatsuka Y,Weissman IL,Greenberg PD
Thu Jun 07 00:00:00 EDT 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F
Tue Oct 02 00:00:00 EDT 2012
Soluble factors produced by activated CD4+ T cells modulate EBV latency.
Proceedings of the National Academy of Sciences of the United States of America
Nagy N,Adori M,Rasul A,Heuts F,Salamon D,Ujvári D,Madapura HS,Leveau B,Klein G,Klein E
Tue Jan 31 00:00:00 EST 2012
Cutting edge: IL-21 derived from human follicular helper T cells acts as a survival factor for secondary lymphoid organ, but not for bone marrow, plasma cells.
Journal of immunology (Baltimore, Md. : 1950)
Rodríguez-Bayona B,Ramos-Amaya A,Bernal J,Campos-Caro A,Brieva JA
Wed Feb 15 00:00:00 EST 2012
In vitro generation of long-lived human plasma cells.
Journal of immunology (Baltimore, Md. : 1950)
Cocco M,Stephenson S,Care MA,Newton D,Barnes NA,Davison A,Rawstron A,Westhead DR,Doody GM,Tooze RM
Sat Dec 15 00:00:00 EST 2012
Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help.
PloS one
Butler MO,Imataki O,Yamashita Y,Tanaka M,Ansén S,Berezovskaya A,Metzler G,Milstein MI,Mooney MM,Murray AP,Mano H,Nadler LM,Hirano N
Mon Jul 09 00:00:00 EDT 2012
IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo.
Blood
Recher M,Berglund LJ,Avery DT,Cowan MJ,Gennery AR,Smart J,Peake J,Wong M,Pai SY,Baxi S,Walter JE,Palendira U,Tangye GA,Rice M,Brothers S,Al-Herz W,Oettgen H,Eibel H,Puck JM,Cattaneo F,Ziegler JB,Giliani S,Tangye SG,Notarangelo LD
Thu Dec 22 00:00:00 EST 2011
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood
Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E
Thu Jan 06 00:00:00 EST 2011
Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.
The Journal of clinical investigation
Kardava L,Moir S,Wang W,Ho J,Buckner CM,Posada JG,O'Shea MA,Roby G,Chen J,Sohn HW,Chun TW,Pierce SK,Fauci AS
Fri Jul 01 00:00:00 EDT 2011
Mycophenolic acid differentially impacts B cell function depending on the stage of differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Karnell JL,Karnell FG,Stephens GL,Rajan B,Morehouse C,Li Y,Swerdlow B,Wilson M,Goldbach-Mansky R,Groves C,Coyle AJ,Herbst R,Ettinger R
Sat Oct 01 00:00:00 EDT 2011
CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Chevalier N,Jarrossay D,Ho E,Avery DT,Ma CS,Yu D,Sallusto F,Tangye SG,Mackay CR
Sun May 15 00:00:00 EDT 2011
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)
Ansari NA,Kumar R,Gautam S,Nylén S,Singh OP,Sundar S,Sacks D
Fri Apr 01 00:00:00 EDT 2011
IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.
PloS one
Sammicheli S,Dang VP,Ruffin N,Pham HT,Lantto R,Vivar N,Chiodi F,Rethi B
Mon Aug 27 00:00:00 EDT 2012
Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.
Blood
Suryani S,Fulcher DA,Santner-Nanan B,Nanan R,Wong M,Shaw PJ,Gibson J,Williams A,Tangye SG
Thu Jan 21 00:00:00 EST 2010
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.
The Journal of experimental medicine
Avery DT,Deenick EK,Ma CS,Suryani S,Simpson N,Chew GY,Chan TD,Palendira U,Bustamante J,Boisson-Dupuis S,Choo S,Bleasel KE,Peake J,King C,French MA,Engelhard D,Al-Hajjar S,Al-Muhsen S,Magdorf K,Roesler J,Arkwright PD,Hissaria P,Riminton DS,Wong M,Brink R,Fulcher DA,Casanova JL,Cook MC,Tangye SG
Mon Jan 18 00:00:00 EST 2010
IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter.
Proceedings of the National Academy of Sciences of the United States of America
Kis LL,Salamon D,Persson EK,Nagy N,Scheeren FA,Spits H,Klein G,Klein E
Tue Jan 12 00:00:00 EST 2010
Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Thu Jul 15 00:00:00 EDT 2010
Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.
PloS one
Tran E,Nielsen JS,Wick DA,Ng AV,Johnson LD,Nesslinger NJ,McMurtrie E,Webb JR,Nelson BH
Wed Dec 22 00:00:00 EST 2010
C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells.
Blood
Pal R,Janz M,Galson DL,Gries M,Li S,Jöhrens K,Anagnostopoulos I,Dörken B,Mapara MY,Borghesi L,Kardava L,Roodman GD,Milcarek C,Lentzsch S
Thu Oct 29 00:00:00 EDT 2009
Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.
Immunology and cell biology
Ma CS,Suryani S,Avery DT,Chan A,Nanan R,Santner-Nanan B,Deenick EK,Tangye SG
Thu Jan 14 00:00:00 EST 2010
Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.
The Journal of biological chemistry
Lindemann MJ,Hu Z,Benczik M,Liu KD,Gaffen SL
Fri May 16 00:00:00 EDT 2008
Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Good KL,Bryant VL,Tangye SG
Sun Oct 15 00:00:00 EDT 2006
