Gibco

Human IL-23 Recombinant Protein, PeproTech®

Product Details

200-23-10UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 79 publications 79 publications

Miscellaneous PubMed (Misc)

View 3 publications 3 publications

Product Specifications

Species

Human

Published species

Human, Mouse

Expression System

Insect cells

Amino acid sequence

p19 subunit: RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP p40 subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS

Molecular weight

53.5 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Measured by its ability to induce IL-17 secretion by mouse splenocytes.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

200-23-1MG will be provided as 2 x 500 µg (200-23-500UG).

Recombinant Human IL-23 is a 53.5 kDa, heterodimeric protein consisting of the two subunits, p19 (170 amino acids) and p40 (306 amino acids).

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 that is disulfide-linked with to two subunits, a p19 subunit unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 interacts with IL-12Rbeta1 and a beta2-like receptor subunit with STAT4 binding domain, IL-23R. IL-23 is secreted by activated mouse and human dendritic cells and is involved in the inflammation process and associated with autoimmune diseases. Mouse IL-23 was found not to induce significant amounts of IFN-gamma, induces strong proliferation of memory T cells (but not naive T cells), and activate mouse memory T cells to produce the proinflammatory cytokine IL-17. On the other hand, human IL-23 induces proliferation of memory T cells, induces moderate levels of IFN-gamma, and is produced by naive and memory T cells. IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance, and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines. IL-23 interacts with the receptors IL-12R beta1 and IL-23R to activate the Jak-Stat signaling cascade. IL-23 has been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.

International journal of biological sciences

Chen M,Peng Q,Tan Z,Xu S,Wang Y,Wu A,Xiao W,Wang Q,Xie H,Li J,Shi W,Deng Z

200-23 was used in Cell Culture to reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.

Tue Nov 07 00:00:00 EST 2023

The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.

The Journal of experimental medicine

Krzywinska E,Sobecki M,Nagarajan S,Zacharjasz J,Tambuwala MM,Pelletier A,Cummins E,Gotthardt D,Fandrey J,Kerdiles YM,Peyssonnaux C,Taylor CT,Sexl V,Stockmann C

Mon Feb 07 00:00:00 EST 2022

Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.

JID innovations : skin science from molecules to population health

Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH

200-23 was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.

Sat Jan 01 00:00:00 EST 2022

Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.

Viruses

Cruz-Lorenzo E,Ramirez NP,Lee J,Pandhe S,Wang L,Hernandez-Doria J,Spivak AM,Planelles V,Petersen T,Jain MK,Martinez ED,D'Orso I

200-23 was used in Cell Culture to suggest that manipulation of redox-sensitive pathways could be exploited to alter the course of HIV-1 latency, thus rendering host cells responsive to help achieve a sterilizing cure.

Tue Oct 18 00:00:00 EDT 2022

Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.

Cellular and molecular gastroenterology and hepatology

Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR

200-23 was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.

Mon Apr 04 00:00:00 EDT 2022

Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.

Cell research

Liu C,Gong Y,Zhang H,Yang H,Zeng Y,Bian Z,Xin Q,Bai Z,Zhang M,He J,Yan J,Zhou J,Li Z,Ni Y,Wen A,Lan Y,Hu H,Liu B

Fri Oct 01 00:00:00 EDT 2021

Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.

Arthritis & rheumatology (Hoboken, N.J.)

Vecellio M,Chen L,Cohen CJ,Cortes A,Li Y,Bonham S,Selmi C,Brown MA,Fischer R,Knight JC,Wordsworth BP

Tue Jun 01 00:00:00 EDT 2021

Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.

Journal of immunology (Baltimore, Md. : 1950)

Jang YS,Song HE,Seo GY,Jo HJ,Park S,Park HW,Kim TG,Kang SG,Yoon SI,Ko HJ,Lee GS,Park SR,Kim PH

Mon Nov 15 00:00:00 EST 2021

HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4⁺ T Cell Activation and Th17 Cell Differentiation.

Journal of immunology research

Yu S,Tripod M,Atasoy U,Chen J

Mon Jan 10 00:00:00 EST 2022

Histone deacetylase 3 represses cholesterol efflux during CD4⁺ T-cell activation.

eLife

Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS

200-23 was used in In vitro experiments to demonstrate HDAC3 is essential during CD4+ T-cell activation to repress cholesterol efflux.

Thu Dec 02 00:00:00 EST 2021

ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.

Cell reports

Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J

Tue Aug 24 00:00:00 EDT 2021

ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.

Cell reports

Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J

Tue Aug 24 00:00:00 EDT 2021

The metabolic hormone leptin promotes the function of T_FH cells and supports vaccine responses.

Nature communications

Deng J,Chen Q,Chen Z,Liang K,Gao X,Wang X,Makota FV,Ong HS,Wan Y,Luo K,Gong D,Yu X,Camuglia S,Zeng Q,Zhou T,Xue F,He J,Wei Y,Xiao F,Ma J,Hill DL,Pierson W,Nguyen THO,Zhou H,Wang Y,Shen W,Sun L,Li Z,Xia Q,Qian K,Ye L,Rockman S,Linterman MA,Kedzierska K,Shen N,Lu L,Yu D

Mon May 24 00:00:00 EDT 2021

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice.

Scientific reports

Sapra L,Dar HY,Bhardwaj A,Pandey A,Kumari S,Azam Z,Upmanyu V,Anwar A,Shukla P,Mishra PK,Saini C,Verma B,Srivastava RK

Tue Jan 19 00:00:00 EST 2021

T-cell expression of Bruton's tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia.

Cellular & molecular immunology

Xia S,Liu X,Cao X,Xu S

Thu Oct 01 00:00:00 EDT 2020

GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.

The Journal of clinical investigation

Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y

Thu Oct 01 00:00:00 EDT 2020

GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.

The Journal of clinical investigation

Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y

Thu Oct 01 00:00:00 EDT 2020

Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments.

The Journal of clinical investigation

Matthias J,Heink S,Picard F,Zeiträg J,Kolz A,Chao YY,Soll D,de Almeida GP,Glasmacher E,Jacobsen ID,Riedel T,Peters A,Floess S,Huehn J,Baumjohann D,Huber M,Korn T,Zielinski CE

Tue Sep 01 00:00:00 EDT 2020

Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1.

Journal of immunology (Baltimore, Md. : 1950)

Vyas SP,Hansda AK,Kaplan MH,Goswami R

Sun Mar 01 00:00:00 EST 2020

Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.

Nature communications

Evans RDR,Antonelou M,Sathiananthamoorthy S,Rega M,Henderson S,Ceron-Gutierrez L,Barcenas-Morales G,Müller CA,Doffinger R,Walsh SB,Salama AD

Mon Aug 31 00:00:00 EDT 2020

IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant.

Cellular and molecular gastroenterology and hepatology

Sun R,Abraham C

200-23 was used in In vitro experiments to identify that autocrine/paracrine IL23 is required for optimal PRR-enhanced macrophage bacterial uptake and intracellular bacterial clearance, define mechanisms regulating IL23R-induced bacterial clearance, and determine how the IBD-protective IL23R-R381Q variant modulates these processes.

Mon Nov 22 00:00:00 EST 2021

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.

The Journal of experimental medicine

Sun X,Cui Y,Feng H,Liu H,Liu X

Mon Dec 02 00:00:00 EST 2019

Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.

The Journal of experimental medicine

Tanaka H,Arima Y,Kamimura D,Tanaka Y,Takahashi N,Uehata T,Maeda K,Satoh T,Murakami M,Akira S

Mon Jun 03 00:00:00 EDT 2019

Pathogenic Role of an IL-23/γδT17/Neutrophil Axis in Coxsackievirus B3-Induced Pancreatitis.

Journal of immunology (Baltimore, Md. : 1950)

Yan K,Yang J,Qian Q,Xu D,Liu H,Wei L,Li M,Xu W

Sun Dec 15 00:00:00 EST 2019

Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells.

The Journal of biological chemistry

Yin W,Song Y,Chang X

Fri Jan 04 00:00:00 EST 2019

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer.

Nature

Calcinotto A,Spataro C,Zagato E,Di Mitri D,Gil V,Crespo M,De Bernardis G,Losa M,Mirenda M,Pasquini E,Rinaldi A,Sumanasuriya S,Lambros MB,Neeb A,Lucianò R,Bravi CA,Nava-Rodrigues D,Dolling D,Prayer-Galetti T,Ferreira A,Briganti A,Esposito A,Barry S,Yuan W,Sharp A,de Bono J,Alimonti A

Sun Jul 01 00:00:00 EDT 2018

Vitamin D Switches BAF Complexes to Protect β Cells.

Cell

Wei Z,Yoshihara E,He N,Hah N,Fan W,Pinto AFM,Huddy T,Wang Y,Ross B,Estepa G,Dai Y,Ding N,Sherman MH,Fang S,Zhao X,Liddle C,Atkins AR,Yu RT,Downes M,Evans RM

Thu May 17 00:00:00 EDT 2018

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.

Cell

Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M

Thu Jan 25 00:00:00 EST 2018

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.

Immunity

Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W

Tue Apr 17 00:00:00 EDT 2018

The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells.

Immunity

Bando JK,Gilfillan S,Song C,McDonald KG,Huang SC,Newberry RD,Kobayashi Y,Allan DSJ,Carlyle JR,Cella M,Colonna M

Tue Jun 19 00:00:00 EDT 2018

Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.

Immunity

Wang Z,Yin W,Zhu L,Li J,Yao Y,Chen F,Sun M,Zhang J,Shen N,Song Y,Chang X

Tue Jul 17 00:00:00 EDT 2018

MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.

The Journal of clinical investigation

Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q

Fri Jun 01 00:00:00 EDT 2018

Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.

The Journal of experimental medicine

Li N,van Unen V,Höllt T,Thompson A,van Bergen J,Pezzotti N,Eisemann E,Vilanova A,Chuva de Sousa Lopes SM,Lelieveldt BPF,Koning F

Mon May 07 00:00:00 EDT 2018

Contextual control of skin immunity and inflammation by Corynebacterium.

The Journal of experimental medicine

Ridaura VK,Bouladoux N,Claesen J,Chen YE,Byrd AL,Constantinides MG,Merrill ED,Tamoutounour S,Fischbach MA,Belkaid Y

Mon Mar 05 00:00:00 EST 2018

Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.

Proceedings of the National Academy of Sciences of the United States of America

Robichaud N,Hsu BE,Istomine R,Alvarez F,Blagih J,Ma EH,Morales SV,Dai DL,Li G,Souleimanova M,Guo Q,Del Rincon SV,Miller WH,Ramón Y Cajal S,Park M,Jones RG,Piccirillo CA,Siegel PM,Sonenberg N

Tue Mar 06 00:00:00 EST 2018

IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.

Nature communications

Zhao M,Tan Y,Peng Q,Huang C,Guo Y,Liang G,Zhu B,Huang Y,Liu A,Wang Z,Li M,Gao X,Wu R,Wu H,Long H,Lu Q

Thu Feb 08 00:00:00 EST 2018

miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.

The Journal of clinical investigation

Li B,Wang X,Choi IY,Wang YC,Liu S,Pham AT,Moon H,Smith DJ,Rao DS,Boldin MP,Yang L

Mon Oct 02 00:00:00 EDT 2017

TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.

The Journal of experimental medicine

Pattarini L,Trichot C,Bogiatzi S,Grandclaudon M,Meller S,Keuylian Z,Durand M,Volpe E,Madonna S,Cavani A,Chiricozzi A,Romanelli M,Hori T,Hovnanian A,Homey B,Soumelis V

Mon May 01 00:00:00 EDT 2017

A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Montoya MM,Maul J,Singh PB,Pua HH,Dahlström F,Wu N,Huang X,Ansel KM,Baumjohann D

Sat Jul 15 00:00:00 EDT 2017

Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production.

Journal of immunology (Baltimore, Md. : 1950)

Olson MR,Ulrich BJ,Hummel SA,Khan I,Meuris B,Cherukuri Y,Dent AL,Janga SC,Kaplan MH

Thu Jun 01 00:00:00 EDT 2017

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.

Scientific reports

Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H

Mon Feb 06 00:00:00 EST 2017

Butyrate and propionate inhibit antigen-specific CD8⁺ T cell activation by suppressing IL-12 production by antigen-presenting cells.

Scientific reports

Nastasi C,Fredholm S,Willerslev-Olsen A,Hansen M,Bonefeld CM,Geisler C,Andersen MH,Ødum N,Woetmann A

Mon Nov 06 00:00:00 EST 2017

Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.

Nature communications

Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A

Mon Oct 09 00:00:00 EDT 2017

IL-15 sustains IL-7R-independent ILC2 and ILC3 development.

Nature communications

Robinette ML,Bando JK,Song W,Ulland TK,Gilfillan S,Colonna M

Fri Mar 31 00:00:00 EDT 2017

Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression.

Scientific reports

Chen J,Adamiak W,Huang G,Atasoy U,Rostami A,Yu S

Fri Dec 08 00:00:00 EST 2017

Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.

Immunity

Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG

Tue Sep 20 00:00:00 EDT 2016

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.

The Journal of experimental medicine

Ma CS,Wong N,Rao G,Nguyen A,Avery DT,Payne K,Torpy J,O'Young P,Deenick E,Bustamante J,Puel A,Okada S,Kobayashi M,Martinez-Barricarte R,Elliott M,Sebnem Kilic S,El Baghdadi J,Minegishi Y,Bousfiha A,Robertson N,Hambleton S,Arkwright PD,French M,Blincoe AK,Hsu P,Campbell DE,Stormon MO,Wong M,Adelstein S,Fulcher DA,Cook MC,Stepensky P,Boztug K,Beier R,Ikincioğullari A,Ziegler JB,Gray P,Picard C,Boisson-Dupuis S,Phan TG,Grimbacher B,Warnatz K,Holland SM,Uzel G,Casanova JL,Tangye SG

Mon Jul 25 00:00:00 EDT 2016

Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.

Proceedings of the National Academy of Sciences of the United States of America

Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC

Tue Aug 16 00:00:00 EDT 2016

STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Olson MR,Verdan FF,Hufford MM,Dent AL,Kaplan MH

Fri Apr 15 00:00:00 EDT 2016

The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Koh B,Hufford MM,Pham D,Olson MR,Wu T,Jabeen R,Sun X,Kaplan MH

Thu Sep 15 00:00:00 EDT 2016

ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.

Journal of immunology (Baltimore, Md. : 1950)

Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V

Sat Oct 01 00:00:00 EDT 2016

Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.

Scientific reports

Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I

Tue May 17 00:00:00 EDT 2016

RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.

Scientific reports

Drujont L,Lemoine A,Moreau A,Bienvenu G,Lancien M,Cens T,Guillot F,Bériou G,Bouchet-Delbos L,Fehling HJ,Chiffoleau E,Nicot AB,Charnet P,Martin JC,Josien R,Cuturi MC,Louvet C

Thu Mar 24 00:00:00 EDT 2016

Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.

The Journal of biological chemistry

Pasi S,Kant R,Surolia A

Fri Jun 03 00:00:00 EDT 2016

Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.

The Journal of clinical investigation

Zhang Z,Cheng L,Zhao J,Li G,Zhang L,Chen W,Nie W,Reszka-Blanco NJ,Wang FS,Su L

Tue Sep 01 00:00:00 EDT 2015

The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.

The Journal of experimental medicine

Barnes MJ,Li CM,Xu Y,An J,Huang Y,Cyster JG

Mon Jun 29 00:00:00 EDT 2015

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Proceedings of the National Academy of Sciences of the United States of America

Hammitzsch A,Tallant C,Fedorov O,O'Mahony A,Brennan PE,Hay DA,Martinez FO,Al-Mossawi MH,de Wit J,Vecellio M,Wells C,Wordsworth P,Müller S,Knapp S,Bowness P

Tue Aug 25 00:00:00 EDT 2015

Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs.

Proceedings of the National Academy of Sciences of the United States of America

Fiebiger BM,Maamary J,Pincetic A,Ravetch JV

Tue May 05 00:00:00 EDT 2015

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.

European journal of immunology

Reppert S,Zinser E,Holzinger C,Sandrock L,Koch S,Finotto S

Fri May 01 00:00:00 EDT 2015

Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Ding X,Yan Y,Li X,Li K,Ciric B,Yang J,Zhang Y,Wu S,Xu H,Chen W,Lovett-Racke AE,Zhang GX,Rostami A

Fri May 01 00:00:00 EDT 2015

Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1.

Scientific reports

Wang Y,Xing F,Ye S,Xiao J,Di J,Zeng S,Liu J

Wed Feb 04 00:00:00 EST 2015

IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection.

Nature communications

Adoro S,Cubillos-Ruiz JR,Chen X,Deruaz M,Vrbanac VD,Song M,Park S,Murooka TT,Dudek TE,Luster AD,Tager AM,Streeck H,Bowman B,Walker BD,Kwon DS,Lazarevic V,Glimcher LH

Thu Jun 25 00:00:00 EDT 2015

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.

Scientific reports

Mailer RK,Joly AL,Liu S,Elias S,Tegner J,Andersson J

Tue Oct 06 00:00:00 EDT 2015

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.

Nature communications

Cook PC,Owen H,Deaton AM,Borger JG,Brown SL,Clouaire T,Jones GR,Jones LH,Lundie RJ,Marley AK,Morrison VL,Phythian-Adams AT,Wachter E,Webb LM,Sutherland TE,Thomas GD,Grainger JR,Selfridge J,McKenzie AN,Allen JE,Fagerholm SC,Maizels RM,Ivens AC,Bird A,MacDonald AS

Fri Apr 24 00:00:00 EDT 2015

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.

Nature communications

Yoon JH,Sudo K,Kuroda M,Kato M,Lee IK,Han JS,Nakae S,Imamura T,Kim J,Ju JH,Kim DK,Matsuzaki K,Weinstein M,Matsumoto I,Sumida T,Mamura M

Tue Jul 21 00:00:00 EDT 2015

Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

Immunity

Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR

Thu Sep 18 00:00:00 EDT 2014

Interleukin (IL)-17A, F and AF in inflammation: a study in collagen-induced arthritis and rheumatoid arthritis.

Clinical and experimental immunology

Sarkar S,Justa S,Brucks M,Endres J,Fox DA,Zhou X,Alnaimat F,Whitaker B,Wheeler JC,Jones BH,Bommireddy SR

Mon Sep 01 00:00:00 EDT 2014

Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.

Immunity

Fuchs A,Vermi W,Lee JS,Lonardi S,Gilfillan S,Newberry RD,Cella M,Colonna M

Thu Apr 18 00:00:00 EDT 2013

Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.

Immunity

Fuchs A,Vermi W,Lee JS,Lonardi S,Gilfillan S,Newberry RD,Cella M,Colonna M

Thu Apr 18 00:00:00 EDT 2013

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.

The Journal of clinical investigation

Ye P,Chen W,Wu J,Huang X,Li J,Wang S,Liu Z,Wang G,Yang X,Zhang P,Lv Q,Xia J

Wed May 01 00:00:00 EDT 2013

Lymphocyte-derived ACh regulates local innate but not adaptive immunity.

Proceedings of the National Academy of Sciences of the United States of America

Reardon C,Duncan GS,Brüstle A,Brenner D,Tusche MW,Olofsson PS,Rosas-Ballina M,Tracey KJ,Mak TW

Tue Jan 22 00:00:00 EST 2013

MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.

Proceedings of the National Academy of Sciences of the United States of America

Chang J,Burkett PR,Borges CM,Kuchroo VK,Turka LA,Chang CH

Tue Feb 05 00:00:00 EST 2013

Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide.

Journal of immunology (Baltimore, Md. : 1950)

Eigenbrod T,Bode KA,Dalpke AH

Sat Jun 15 00:00:00 EDT 2013

Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Yamashita J,Iwamura C,Ito T,Narita M,Hara Y,Sasaki T,Masuda D,Takahashi M,Tsuchiya M,Hada K,Ishikawa M,Matsuo T,Ohno Y,Tanaka H,Maruyama H,Ogawa Y,Nakayama T

Mon Jul 15 00:00:00 EDT 2013

Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

Journal of immunology (Baltimore, Md. : 1950)

Pham D,Yu Q,Walline CC,Muthukrishnan R,Blum JS,Kaplan MH

Mon Jul 15 00:00:00 EDT 2013

IL-23-independent induction of IL-17 from γδT cells and innate lymphoid cells promotes experimental intraocular neovascularization.

Journal of immunology (Baltimore, Md. : 1950)

Hasegawa E,Sonoda KH,Shichita T,Morita R,Sekiya T,Kimura A,Oshima Y,Takeda A,Yoshimura T,Yoshida S,Ishibashi T,Yoshimura A

Fri Feb 15 00:00:00 EST 2013

An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R

Tue Jan 01 00:00:00 EST 2013

The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.

The Journal of biological chemistry

Pham D,Walline CC,Hollister K,Dent AL,Blum JS,Firulli AB,Kaplan MH

Fri Sep 20 00:00:00 EDT 2013

SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection.

Cellular & molecular immunology

Zhang X,Han S,Kang Y,Guo M,Hong S,Liu F,Fu S,Wang L,Wang QX

Sat Sep 01 00:00:00 EDT 2012

Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.

Journal of immunology (Baltimore, Md. : 1950)

Pham D,Vincentz JW,Firulli AB,Kaplan MH

Sun Jul 15 00:00:00 EDT 2012

De novo DNA methylation is required to restrict T helper lineage plasticity.

The Journal of biological chemistry

Thomas RM,Gamper CJ,Ladle BH,Powell JD,Wells AD

Fri Jun 29 00:00:00 EDT 2012

SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.

Blood

Giroux M,Delisle JS,Gauthier SD,Heinonen KM,Hinsinger J,Houde B,Gaboury L,Brochu S,Wu J,Hébert MJ,Perreault C

Thu Feb 03 00:00:00 EST 2011

Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.

Journal of immunology (Baltimore, Md. : 1950)

Van Belle TL,Esplugues E,Liao J,Juntti T,Flavell RA,von Herrath MG

Thu Sep 15 00:00:00 EDT 2011

Low-strength T-cell activation promotes Th17 responses.

Blood

Purvis HA,Stoop JN,Mann J,Woods S,Kozijn AE,Hambleton S,Robinson JH,Isaacs JD,Anderson AE,Hilkens CM

Thu Dec 02 00:00:00 EST 2010

Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients.

Journal of immunology (Baltimore, Md. : 1950)

Kuang DM,Peng C,Zhao Q,Wu Y,Zhu LY,Wang J,Yin XY,Li L,Zheng L

Sun Aug 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: IL-23 subunit alpha; IL-23-A; IL-23p19; IL23; ILN; Interleukin; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; Interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation

Human IL-23 Recombinant Protein, PeproTech®

Product Details

200-23-10UG

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

We're here to help

Your items have has been added!