Product References
The interferon landscape along the respiratory tract impacts the severity of COVID-19.
Cell
Sposito B,Broggi A,Pandolfi L,Crotta S,Clementi N,Ferrarese R,Sisti S,Criscuolo E,Spreafico R,Long JM,Ambrosi A,Liu E,Frangipane V,Saracino L,Bozzini S,Marongiu L,Facchini FA,Bottazzi A,Fossali T,Colombo R,Clementi M,Tagliabue E,Chou J,Pontiroli AE,Meloni F,Wack A,Mancini N,Zanoni I
Thu Sep 16 00:00:00 EDT 2021
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly.
Cell stem cell
Krenn V,Bosone C,Burkard TR,Spanier J,Kalinke U,Calistri A,Salata C,Rilo Christoff R,Pestana Garcez P,Mirazimi A,Knoblich JA
Thu Aug 05 00:00:00 EDT 2021
An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells.
The EMBO journal
Lamers MM,van der Vaart J,Knoops K,Riesebosch S,Breugem TI,Mykytyn AZ,Beumer J,Schipper D,Bezstarosti K,Koopman CD,Groen N,Ravelli RBG,Duimel HQ,Demmers JAA,Verjans GMGM,Koopmans MPG,Muraro MJ,Peters PJ,Clevers H,Haagmans BL
300-02L was used in Cell Culture to represent an experimental model for SARS-CoV-2 infection and can be applied for drug screens.
Mon Mar 01 00:00:00 EST 2021
Enterovirus 71 Antagonizes Antiviral Effects of Type III Interferon and Evades the Clearance of Intestinal Intraepithelial Lymphocytes.
Frontiers in microbiology
Dong Y,Liu J,Lu N,Zhang C
300-02L was used in Cell Culture to provide novel evasion mechanisms of EV71 from intestinal mucosal innate immunity and may give new insights into antiviral therapy.
Wed Feb 23 00:00:00 EST 2022
Entecavir-induced interferon-λ1 suppresses type 2 innate lymphoid cells in patients with hepatitis B virus-related liver cirrhosis.
Journal of viral hepatitis
Wang SQ,Shen Y,Li J,Liu Y,Cheng LS,Wu SD,She WM,Jiang W
300-02L was used in In vitro experiments to determine the effects of ETV on non-natural killer innate lymphoid cells (non-NK ILCs) in HBV-related liver disease progression.
Sat May 01 00:00:00 EDT 2021
Triggering of the cGAS-STING Pathway in Human Plasmacytoid Dendritic Cells Inhibits TLR9-Mediated IFN Production.
Journal of immunology (Baltimore, Md. : 1950)
Deb P,Dai J,Singh S,Kalyoussef E,Fitzgerald-Bocarsly P
Wed Jul 01 00:00:00 EDT 2020
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2.
mBio
Busnadiego I,Fernbach S,Pohl MO,Karakus U,Huber M,Trkola A,Stertz S,Hale BG
300-02L was used in Cell Culture to investigated properties of type I (β), II (γ), and III (λ1) interferons (IFNs), potent immune cytokines that are normally produced during infection and that upregulate IFN-stimulated gene (ISG) effectors to limit virus replication.
Thu Sep 10 00:00:00 EDT 2020
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2.
mBio
Busnadiego I,Fernbach S,Pohl MO,Karakus U,Huber M,Trkola A,Stertz S,Hale BG
300-02L was used in Cell Culture to investigated properties of type I (β), II (γ), and III (λ1) interferons (IFNs), potent immune cytokines that are normally produced during infection and that upregulate IFN-stimulated gene (ISG) effectors to limit virus replication.
Thu Sep 10 00:00:00 EDT 2020
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.
Cell reports
Stanifer ML,Kee C,Cortese M,Zumaran CM,Triana S,Mukenhirn M,Kraeusslich HG,Alexandrov T,Bartenschlager R,Boulant S
300-02L was used in Cell Culture to demonstrate that human intestinal epithelial cells are a productive site of SARS-CoV-2 replication and that the enteric phase of SARS-CoV-2 may participate in the pathologies observed in COVID-19 patients.
Tue Jul 07 00:00:00 EDT 2020
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.
Cell reports
Stanifer ML,Kee C,Cortese M,Zumaran CM,Triana S,Mukenhirn M,Kraeusslich HG,Alexandrov T,Bartenschlager R,Boulant S
300-02L was used in Cell Culture to demonstrate that human intestinal epithelial cells are a productive site of SARS-CoV-2 replication and that the enteric phase of SARS-CoV-2 may participate in the pathologies observed in COVID-19 patients.
Tue Jul 07 00:00:00 EDT 2020
Diminished secretion and function of IL-29 is associated with impaired IFN-α response of neonatal plasmacytoid dendritic cells.
Journal of leukocyte biology
Wisgrill L,Wessely I,Netzl A,Pummer L,Sadeghi K,Spittler A,Berger A,Förster-Waldl E
Fri Nov 01 00:00:00 EDT 2019
Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection.
The Journal of biological chemistry
Zhang Y,Tada T,Ozono S,Yao W,Tanaka M,Yamaoka S,Kishigami S,Fujita H,Tokunaga K
Fri Mar 08 00:00:00 EST 2019
Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells.
Cells
Bilz NC,Willscher E,Binder H,Böhnke J,Stanifer ML,Hübner D,Boulant S,Liebert UG,Claus C
300-02L was used in Sample Preparation (FC/FACS) to study the correlation of the molecular alterations induced by rubella virus (RV) during differentiation of induced pluripotent stem cells (iPSCs).
Sat Aug 10 00:00:00 EDT 2019
Generation and characterization of a stable cell line persistently replicating and secreting the human hepatitis delta virus.
Scientific reports
Ni Y,Zhang Z,Engelskircher L,Verch G,Tu T,Lempp FA,Urban S
Wed Jul 10 00:00:00 EDT 2019
Characterization of signaling pathways regulating the expression of pro-inflammatory long form thymic stromal lymphopoietin upon human metapneumovirus infection.
Scientific reports
Li Y,Lund C,Nervik I,Loevenich S,Døllner H,Anthonsen MW,Johnsen IB
Wed Jan 17 00:00:00 EST 2018
Characterization of signaling pathways regulating the expression of pro-inflammatory long form thymic stromal lymphopoietin upon human metapneumovirus infection.
Scientific reports
Li Y,Lund C,Nervik I,Loevenich S,Døllner H,Anthonsen MW,Johnsen IB
Wed Jan 17 00:00:00 EST 2018
Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface.
Nature communications
Gouilly J,Chen Q,Siewiera J,Cartron G,Levy C,Dubois M,Al-Daccak R,Izopet J,Jabrane-Ferrat N,El Costa H
Mon Nov 12 00:00:00 EST 2018
Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
Cell
Chen K,Liu J,Liu S,Xia M,Zhang X,Han D,Jiang Y,Wang C,Cao X
300-02L was used in In vitro experiments to identify STAT1 methylation on K525 catalyzed by the methyltransferase SETD2 as an essential signaling event for IFNα-dependent antiviral immunity and indicates potential of SETD2 in controlling viral infections.
Thu Jul 27 00:00:00 EDT 2017
Detection of interferon alpha protein reveals differential levels and cellular sources in disease.
The Journal of experimental medicine
Rodero MP,Decalf J,Bondet V,Hunt D,Rice GI,Werneke S,McGlasson SL,Alyanakian MA,Bader-Meunier B,Barnerias C,Bellon N,Belot A,Bodemer C,Briggs TA,Desguerre I,Frémond ML,Hully M,van den Maagdenberg AMJM,Melki I,Meyts I,Musset L,Pelzer N,Quartier P,Terwindt GM,Wardlaw J,Wiseman S,Rieux-Laucat F,Rose Y,Neven B,Hertel C,Hayday A,Albert ML,Rozenberg F,Crow YJ,Duffy D
Mon May 01 00:00:00 EDT 2017
Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut.
Frontiers in immunology
Pervolaraki K,Stanifer ML,Münchau S,Renn LA,Albrecht D,Kurzhals S,Senís E,Grimm D,Schröder-Braunstein J,Rabin RL,Boulant S
300-02L was used in In vitro experiments to suggest that type III interferon constitutes the frontline of antiviral response in the human gut.
Mon Mar 21 00:00:00 EDT 2022
Type III IFNs Are Commonly Induced by Bacteria-Sensing TLRs and Reinforce Epithelial Barriers during Infection.
Journal of immunology (Baltimore, Md. : 1950)
Odendall C,Voak AA,Kagan JC
Wed Nov 01 00:00:00 EDT 2017
SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)-induced gene expression in vivo.
The Journal of biological chemistry
Blumer T,Coto-Llerena M,Duong FHT,Heim MH
Fri Oct 27 00:00:00 EDT 2017
Transcriptional regulation of IFN-λ genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex.
The Journal of biological chemistry
Lee HC,Narayanan S,Park SJ,Seong SY,Hahn YS
Fri Feb 21 00:00:00 EST 2014
Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Yin Z,Dai J,Deng J,Sheikh F,Natalia M,Shih T,Lewis-Antes A,Amrute SB,Garrigues U,Doyle S,Donnelly RP,Kotenko SV,Fitzgerald-Bocarsly P
Sat Sep 15 00:00:00 EDT 2012
Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells.
PloS one
Dolganiuc A,Kodys K,Marshall C,Saha B,Zhang S,Bala S,Szabo G
Tue Apr 02 00:00:00 EDT 2013
IFN-λ3 inhibits HIV infection of macrophages through the JAK-STAT pathway.
PloS one
Liu MQ,Zhou DJ,Wang X,Zhou W,Ye L,Li JL,Wang YZ,Ho WZ
Thu Sep 13 00:00:00 EDT 2012
The human respiratory syncytial virus nonstructural protein 1 regulates type I and type II interferon pathways.
Molecular & cellular proteomics : MCP
Hastie ML,Headlam MJ,Patel NB,Bukreyev AA,Buchholz UJ,Dave KA,Norris EL,Wright CL,Spann KM,Collins PL,Gorman JJ
Tue May 01 00:00:00 EDT 2012
The human respiratory syncytial virus nonstructural protein 1 regulates type I and type II interferon pathways.
Molecular & cellular proteomics : MCP
Hastie ML,Headlam MJ,Patel NB,Bukreyev AA,Buchholz UJ,Dave KA,Norris EL,Wright CL,Spann KM,Collins PL,Gorman JJ
Tue May 01 00:00:00 EDT 2012
LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop.
PloS one
Hu J,Lou D,Carow B,Winerdal ME,Rottenberg M,Wikström AC,Norstedt G,Winqvist O
Mon Jun 04 00:00:00 EDT 2012
Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: its correlation with disease activity.
Arthritis research & therapy
Wu Q,Yang Q,Lourenco E,Sun H,Zhang Y
Thu Jun 16 00:00:00 EDT 2011
USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response.
PloS one
François-Newton V,Magno de Freitas Almeida G,Payelle-Brogard B,Monneron D,Pichard-Garcia L,Piehler J,Pellegrini S,Uzé G
Tue Nov 15 00:00:00 EST 2011
Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3.
Journal of immunology (Baltimore, Md. : 1950)
Huber JP,Ramos HJ,Gill MA,Farrar JD
Thu Jul 15 00:00:00 EDT 2010
Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection.
PloS one
Yoshikawa T,Hill TE,Yoshikawa N,Popov VL,Galindo CL,Garner HR,Peters CJ,Tseng CT
Fri Jan 15 00:00:00 EST 2010
IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells.
Blood
Dai J,Megjugorac NJ,Gallagher GE,Yu RY,Gallagher G
Thu Jun 04 00:00:00 EDT 2009
Human interferon-lambda3 is a potent member of the type III interferon family.
Genes and immunity
Dellgren C,Gad HH,Hamming OJ,Melchjorsen J,Hartmann R
Sun Mar 01 00:00:00 EST 2009
Interleukin-29 functions cooperatively with interferon to induce antiviral gene expression and inhibit hepatitis C virus replication.
The Journal of biological chemistry
Pagliaccetti NE,Eduardo R,Kleinstein SH,Mu XJ,Bandi P,Robek MD
Fri Oct 31 00:00:00 EDT 2008
IL-28 and IL-29: newcomers to the interferon family.
Biochimie
Uzé G,Monneron D
Fri Sep 14 00:00:00 EDT 2007
Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner.
Genes and immunity
Pekarek V,Srinivas S,Eskdale J,Gallagher G
Thu Mar 01 00:00:00 EST 2007
Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells.
Blood
Mennechet FJ,Uzé G
Thu Jun 01 00:00:00 EDT 2006
Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells.
Blood
Mennechet FJ,Uzé G
Thu Jun 01 00:00:00 EDT 2006
