Gibco

Human IL-4, Animal-Free Recombinant Protein, PeproTech®

Product Details

AF-200-04-20UG

Applications

Tested Dilution

Publications

ELISA (ELISA)

View 1 publication 1 publication

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 87 publications 87 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Human, Mouse

Expression System

E. coli

Amino acid sequence

MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS

Molecular weight

15.1 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<0.1 EU/µg

Activity

The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial.

Nature medicine

Creelan BC,Wang C,Teer JK,Toloza EM,Yao J,Kim S,Landin AM,Mullinax JE,Saller JJ,Saltos AN,Noyes DR,Montoya LB,Curry W,Pilon-Thomas SA,Chiappori AA,Tanvetyanon T,Kaye FJ,Thompson ZJ,Yoder SJ,Fang B,Koomen JM,Sarnaik AA,Chen DT,Conejo-Garcia JR,Haura EB,Antonia SJ

Sun Aug 01 00:00:00 EDT 2021

Follicular regulatory T cells produce neuritin to regulate B cells.

Cell

Gonzalez-Figueroa P,Roco JA,Papa I,Núñez Villacís L,Stanley M,Linterman MA,Dent A,Canete PF,Vinuesa CG

Thu Apr 01 00:00:00 EDT 2021

The receptor of the colony-stimulating factor-1 (CSF-1R) is a novel prognostic factor and therapeutic target in follicular lymphoma.

Leukemia

Valero JG,Matas-Céspedes A,Arenas F,Rodriguez V,Carreras J,Serrat N,Guerrero-Hernández M,Yahiaoui A,Balagué O,Martin S,Capdevila C,Hernández L,Magnano L,Rivas-Delgado A,Tannheimer S,Cid MC,Campo E,López-Guillermo A,Colomer D,Pérez-Galán P

Wed Sep 01 00:00:00 EDT 2021

USP24 promotes drug resistance during cancer therapy.

Cell death and differentiation

Wang SA,Young MJ,Wang YC,Chen SH,Liu CY,Lo YA,Jen HH,Hsu KC,Hung JJ

Wed Sep 01 00:00:00 EDT 2021

Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway.

Laboratory investigation; a journal of technical methods and pathology

Cho J,Kim TH,Seok J,Jun JH,Park H,Kweon M,Lim JY,Kim GJ

Mon Mar 01 00:00:00 EST 2021

Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer.

Nature communications

Weng RR,Lu HH,Lin CT,Fan CC,Lin RS,Huang TC,Lin SY,Huang YJ,Juan YH,Wu YC,Hung ZC,Liu C,Lin XH,Hsieh WC,Chiu TY,Liao JC,Chiu YL,Chen SY,Yu CJ,Tsai HC

Mon Apr 12 00:00:00 EDT 2021

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.

Nature communications

Clement CC,D'Alessandro A,Thangaswamy S,Chalmers S,Furtado R,Spada S,Mondanelli G,Ianni F,Gehrke S,Gargaro M,Manni G,Cara LCL,Runge P,Tsai WL,Karaman S,Arasa J,Fernandez-Rodriguez R,Beck A,Macchiarulo A,Gadina M,Halin C,Fallarino F,Skobe M,Veldhoen M,Moretti S,Formenti S,Demaria S,Soni RK,Galarini R,Sardella R,Lauvau G,Putterman C,Alitalo K,Grohmann U,Santambrogio L

Wed Jul 21 00:00:00 EDT 2021

A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function.

Communications biology

To J,Quackenbush D,Rowell E,Li L,Reed C,Lo F,Horman SR

Fri Jan 08 00:00:00 EST 2021

Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis.

The American journal of pathology

Ganieva U,Nakamura T,Osuka S,Nakanishi N,Kasahara Y,Takasaki N,Muraoka A,Hayashi S,Nagai T,Murase T,Goto M,Iwase A,Kikkawa F

AF-200-04 was used in In vitro experiments to study whether transcription factor 21 (TCF21) is involved in the development of endometriosis as an upstream regulatory gene of periostin.

Wed Jan 01 00:00:00 EST 2020

Down-regulated lncRNA SBF2-AS1 in M2 macrophage-derived exosomes elevates miR-122-5p to restrict XIAP, thereby limiting pancreatic cancer development.

Journal of cellular and molecular medicine

Yin Z,Zhou Y,Ma T,Chen S,Shi N,Zou Y,Hou B,Zhang C

Fri May 01 00:00:00 EDT 2020

High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange.

Nature communications

Overall SA,Toor JS,Hao S,Yarmarkovich M,Morozov GI,Nguyen S,Japp AS,Gonzalez N,Moschidi D,Betts MR,Maris JM,Smibert P,Sgourakis NG

Mon Apr 20 00:00:00 EDT 2020

Long non-coding RNA FENDRR regulates IFNγ-induced M1 phenotype in macrophages.

Scientific reports

Munteanu MC,Huang C,Liang Y,Sathiaseelan R,Zeng X,Liu L

Thu Aug 13 00:00:00 EDT 2020

Class-Switch Recombination Occurs Infrequently in Germinal Centers.

Immunity

Roco JA,Mesin L,Binder SC,Nefzger C,Gonzalez-Figueroa P,Canete PF,Ellyard J,Shen Q,Robert PA,Cappello J,Vohra H,Zhang Y,Nowosad CR,Schiepers A,Corcoran LM,Toellner KM,Polo JM,Meyer-Hermann M,Victora GD,Vinuesa CG

Tue Aug 20 00:00:00 EDT 2019

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions.

The Journal of clinical investigation

Chiang N,Libreros S,Norris PC,de la Rosa X,Serhan CN

Mon Dec 02 00:00:00 EST 2019

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.

Cell reports

Di Mitri D,Mirenda M,Vasilevska J,Calcinotto A,Delaleu N,Revandkar A,Gil V,Boysen G,Losa M,Mosole S,Pasquini E,D'Antuono R,Masetti M,Zagato E,Chiorino G,Ostano P,Rinaldi A,Gnetti L,Graupera M,Martins Figueiredo Fonseca AR,Pereira Mestre R,Waugh D,Barry S,De Bono J,Alimonti A

AF-200-04 was used in Cell Culture to identify tumor-associated macrophages as targets in prostate cancer and describe a therapeutic strategy based on CXCR2 blockade to harness anti-tumorigenic potential of macrophages against this disease.

Tue Aug 20 00:00:00 EDT 2019

Short exposure to cold atmospheric plasma induces senescence in human skin fibroblasts and adipose mesenchymal stromal cells.

Scientific reports

Bourdens M,Jeanson Y,Taurand M,Juin N,Carrière A,Clément F,Casteilla L,Bulteau AL,Planat-Bénard V

Mon Jun 17 00:00:00 EDT 2019

Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation.

Journal of immunology (Baltimore, Md. : 1950)

Dai J,Luftig MA

Thu Mar 01 00:00:00 EST 2018

Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells.

Scientific reports

Szabo A,Gogolak P,Koncz G,Foldvari Z,Pazmandi K,Miltner N,Poliska S,Bacsi A,Djurovic S,Rajnavolgyi E

Mon Jan 29 00:00:00 EST 2018

Blocking the recruitment of naive CD4⁺ T cells reverses immunosuppression in breast cancer.

Cell research

Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E

Sat Apr 01 00:00:00 EDT 2017

Follistatin-like protein 1 contributes to dendritic cell and T-lymphocyte activation in nasopharyngeal carcinoma patients by altering nuclear factor κb and Jun N-terminal kinase expression.

Cell biochemistry and function

Wang H,Wu S,Huang S,Yin S,Zou G,Huang K,Zhang Z,Tang A,Wen W

Thu Dec 01 00:00:00 EST 2016

Differential regulation of aldose reductase expression during macrophage polarization depends on hyperglycemia.

Innate immunity

Erbel C,Rupp G,Domschke G,Linden F,Akhavanpoor M,Doesch AO,Katus HA,Gleissner CA

AF-200-04 was used in Cell Culture to show that aldose reductase (AR) expression in macrophages is associated with atherosclerosis and diabetes, and that AR expression is increased under hyperglycaemic conditions.

Fri Apr 01 00:00:00 EDT 2016

Lactobacillus reuteri and Staphylococcus aureus differentially influence the generation of monocyte-derived dendritic cells and subsequent autologous T cell responses.

Immunity, inflammation and disease

Haileselassie Y,Navis M,Vu N,Qazi KR,Rethi B,Sverremark-Ekström E

Thu Sep 01 00:00:00 EDT 2016

Antigenically Modified Human Pluripotent Stem Cells Generate Antigen-Presenting Dendritic Cells.

Scientific reports

Zeng J,Wu C,Wang S

Fri Oct 16 00:00:00 EDT 2015

Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.

PloS one

Nikitin PA,Price AM,McFadden K,Yan CM,Luftig MA

AF-200-04 was used in In vitro experiments to assess the role of the DNA damage response as a limiting factor in the proliferative response to non-viral B-cell mitogens.

Mon Sep 08 00:00:00 EDT 2014

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.

Blood

Martinez FO,Helming L,Milde R,Varin A,Melgert BN,Draijer C,Thomas B,Fabbri M,Crawshaw A,Ho LP,Ten Hacken NH,Cobos Jiménez V,Kootstra NA,Hamann J,Greaves DR,Locati M,Mantovani A,Gordon S

Thu Feb 28 00:00:00 EST 2013

IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.

Journal of immunology (Baltimore, Md. : 1950)

Ding BB,Bi E,Chen H,Yu JJ,Ye BH

Fri Feb 15 00:00:00 EST 2013

Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis.

Journal of immunology (Baltimore, Md. : 1950)

Seshadri C,Turner MT,Lewinsohn DM,Moody DB,Van Rhijn I

Tue Jan 01 00:00:00 EST 2013

Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.

PloS one

Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T

Fri Sep 06 00:00:00 EDT 2013

The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs.

PloS one

Szabo A,Gogolak P,Pazmandi K,Kis-Toth K,Riedl K,Wizel B,Lingnau K,Bacsi A,Rethi B,Rajnavolgyi E

Mon Dec 02 00:00:00 EST 2013

Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function.

The Journal of biological chemistry

So L,Yea SS,Oak JS,Lu M,Manmadhan A,Ke QH,Janes MR,Kessler LV,Kucharski JM,Li LS,Martin MB,Ren P,Jessen KA,Liu Y,Rommel C,Fruman DA

Fri Feb 22 00:00:00 EST 2013

Mast cells play a protumorigenic role in primary cutaneous lymphoma.

Blood

Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K

Thu Sep 06 00:00:00 EDT 2012

DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.

Blood

Hosszu KK,Valentino A,Vinayagasundaram U,Vinayagasundaram R,Joyce MG,Ji Y,Peerschke EI,Ghebrehiwet B

Thu Aug 09 00:00:00 EDT 2012

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology.

Blood

Pello OM,De Pizzol M,Mirolo M,Soucek L,Zammataro L,Amabile A,Doni A,Nebuloni M,Swigart LB,Evan GI,Mantovani A,Locati M

Thu Jan 12 00:00:00 EST 2012

Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.

Blood

Hutter C,Kauer M,Simonitsch-Klupp I,Jug G,Schwentner R,Leitner J,Bock P,Steinberger P,Bauer W,Carlesso N,Minkov M,Gadner H,Stingl G,Kovar H,Kriehuber E

Thu Dec 20 00:00:00 EST 2012

Periostin promotes chronic allergic inflammation in response to Th2 cytokines.

The Journal of clinical investigation

Masuoka M,Shiraishi H,Ohta S,Suzuki S,Arima K,Aoki S,Toda S,Inagaki N,Kurihara Y,Hayashida S,Takeuchi S,Koike K,Ono J,Noshiro H,Furue M,Conway SJ,Narisawa Y,Izuhara K

Sun Jul 01 00:00:00 EDT 2012

Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4.

The Journal of experimental medicine

Junker Y,Zeissig S,Kim SJ,Barisani D,Wieser H,Leffler DA,Zevallos V,Libermann TA,Dillon S,Freitag TL,Kelly CP,Schuppan D

Mon Dec 17 00:00:00 EST 2012

Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.

The Journal of experimental medicine

Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H

Mon Oct 22 00:00:00 EDT 2012

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.

The Journal of experimental medicine

Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ

Mon Jan 16 00:00:00 EST 2012

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.

Proceedings of the National Academy of Sciences of the United States of America

Zervantonakis IK,Hughes-Alford SK,Charest JL,Condeelis JS,Gertler FB,Kamm RD

Tue Aug 21 00:00:00 EDT 2012

C1q limits dendritic cell differentiation and activation by engaging LAIR-1.

Proceedings of the National Academy of Sciences of the United States of America

Son M,Santiago-Schwarz F,Al-Abed Y,Diamond B

Tue Nov 13 00:00:00 EST 2012

Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia.

Journal of clinical immunology

Liu Y,Wu Y,Lam KT,Lee PP,Tu W,Lau YL

Fri Jun 01 00:00:00 EDT 2012

Human papillomavirus type 8 interferes with a novel C/EBPβ-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration.

PLoS pathogens

Sperling T,Ołdak M,Walch-Rückheim B,Wickenhauser C,Doorbar J,Pfister H,Malejczyk M,Majewski S,Keates AC,Smola S

Tue Jan 29 00:00:00 EST 2013

Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent.

Immunology and cell biology

Hillyer P,Mane VP,Schramm LM,Puig M,Verthelyi D,Chen A,Zhao Z,Navarro MB,Kirschman KD,Bykadi S,Jubin RG,Rabin RL

Sat Sep 01 00:00:00 EDT 2012

Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.

Arthritis research & therapy

Li Y,Zhao LD,Tong LS,Qian SN,Ren Y,Zhang L,Ding X,Chen Y,Wang YX,Zhang W,Zeng XF,Zhang FC,Tang FL,Zhang X,Ba DN,He W,Cao XT,Lipsky PE

Wed May 23 00:00:00 EDT 2012

Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells.

Laboratory investigation; a journal of technical methods and pathology

Tsakiris I,Torocsik D,Gyongyosi A,Dozsa A,Szatmari I,Szanto A,Soos G,Nemes Z,Igali L,Marton I,Takats Z,Nagy L,Dezso B

Thu Mar 01 00:00:00 EST 2012

Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.

Journal of immunology (Baltimore, Md. : 1950)

Jeffery LE,Wood AM,Qureshi OS,Hou TZ,Gardner D,Briggs Z,Kaur S,Raza K,Sansom DM

Sat Dec 01 00:00:00 EST 2012

Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Journal of immunology (Baltimore, Md. : 1950)

Lissauer D,Piper K,Goodyear O,Kilby MD,Moss PA

Sun Jul 15 00:00:00 EDT 2012

An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Zhang T,Wu MR,Sentman CL

Sat Sep 01 00:00:00 EDT 2012

Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.

Journal of immunology (Baltimore, Md. : 1950)

Kitamura H,Kobayashi M,Wakita D,Nishimura T

Tue May 01 00:00:00 EDT 2012

Cyanovirin-N inhibits mannose-dependent Mycobacterium-C-type lectin interactions but does not protect against murine tuberculosis.

Journal of immunology (Baltimore, Md. : 1950)

Driessen NN,Boshoff HI,Maaskant JJ,Gilissen SA,Vink S,van der Sar AM,Vandenbroucke-Grauls CM,Bewley CA,Appelmelk BJ,Geurtsen J

Mon Oct 01 00:00:00 EDT 2012

Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity.

Journal of immunology (Baltimore, Md. : 1950)

Kaplan A,Ma J,Kyme P,Wolf AJ,Becker CA,Tseng CW,Liu GY,Underhill DM

Thu Nov 01 00:00:00 EDT 2012

Enhancing immunostimulatory function of human embryonic stem cell-derived dendritic cells by CD1d overexpression.

Journal of immunology (Baltimore, Md. : 1950)

Zeng J,Shahbazi M,Wu C,Toh HC,Wang S

Tue May 01 00:00:00 EDT 2012

Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Saada S,Marget P,Fauchais AL,Lise MC,Chemin G,Sindou P,Martel C,Delpy L,Vidal E,Jaccard A,Troutaud D,Lalloué F,Jauberteau MO

Sat Dec 01 00:00:00 EST 2012

Human γδ T lymphocytes are licensed for professional antigen presentation by interaction with opsonized target cells.

Journal of immunology (Baltimore, Md. : 1950)

Himoudi N,Morgenstern DA,Yan M,Vernay B,Saraiva L,Wu Y,Cohen CJ,Gustafsson K,Anderson J

Wed Feb 15 00:00:00 EST 2012

Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.

Journal of immunology (Baltimore, Md. : 1950)

Gallo RM,Khan MA,Shi J,Kapur R,Wei L,Bailey JC,Liu J,Brutkiewicz RR

Wed Aug 15 00:00:00 EDT 2012

Elevated circulating interleukin-27 in patients with coronary artery disease is associated with dendritic cells, oxidized low-density lipoprotein, and severity of coronary artery stenosis.

Mediators of inflammation

Jin W,Zhao Y,Yan W,Cao L,Zhang W,Wang M,Zhang T,Fu Q,Li Z

Wed Nov 28 00:00:00 EST 2012

Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.

Gene therapy

Silk KM,Silk JD,Ichiryu N,Davies TJ,Nolan KF,Leishman AJ,Carpenter L,Watt SM,Cerundolo V,Fairchild PJ

Mon Oct 01 00:00:00 EDT 2012

Gene expression profiling of dendritic cells in different physiological stages under Cordyceps sinensis treatment.

PloS one

Li CY,Chiang CS,Cheng WC,Wang SC,Cheng HT,Chen CR,Shu WY,Tsai ML,Hseu RS,Chang CW,Huang CY,Fang SH,Hsu IC

Fri Dec 07 00:00:00 EST 2012

Both lethal and edema toxins of Bacillus anthracis disrupt the human dendritic cell chemokine network.

PloS one

Cleret-Buhot A,Mathieu J,Tournier JN,Quesnel-Hellmann A

Thu Apr 25 00:00:00 EDT 2013

Slit2N/Robo1 inhibit HIV-gp120-induced migration and podosome formation in immature dendritic cells by sequestering LSP1 and WASp.

PloS one

Prasad A,Kuzontkoski PM,Shrivastava A,Zhu W,Li DY,Groopman JE

Mon May 06 00:00:00 EDT 2013

DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.

PloS one

Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H

Thu Nov 08 00:00:00 EST 2012

Divergent effects of mycobacterial cell wall glycolipids on maturation and function of human monocyte-derived dendritic cells.

PloS one

Mazurek J,Ignatowicz L,Kallenius G,Svenson SB,Pawlowski A,Hamasur B

Thu Jan 10 00:00:00 EST 2013

Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.

PloS one

Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC

Fri Jun 29 00:00:00 EDT 2012

Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).

PloS one

Suh HS,Choi N,Tarassishin L,Lee SC

Tue Aug 07 00:00:00 EDT 2012

TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets.

Clinical & developmental immunology

Straetemans T,van Brakel M,van Steenbergen S,Broertjes M,Drexhage J,Hegmans J,Lambrecht BN,Lamers C,van Der Bruggen P,Coulie PG,Debets R

Fri Mar 01 00:00:00 EST 2013

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

The Journal of biological chemistry

Lohse S,Brunke C,Derer S,Peipp M,Boross P,Kellner C,Beyer T,Dechant M,van der Winkel JG,Leusen JH,Valerius T

Fri Jul 20 00:00:00 EDT 2012

MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.

PloS one

Testa JS,Shetty V,Hafner J,Nickens Z,Kamal S,Sinnathamby G,Philip R

Wed Apr 24 00:00:00 EDT 2013

Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.

The Journal of biological chemistry

Müller JR,Waldmann TA,Kruhlak MJ,Dubois S

Fri Nov 23 00:00:00 EST 2012

Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype.

Journal of biomedicine & biotechnology

Silk KM,Leishman AJ,Nishimoto KP,Reddy A,Fairchild PJ

Fri Sep 07 00:00:00 EDT 2012

IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.

The Journal of biological chemistry

Bachmann M,Scheiermann P,Härdle L,Pfeilschifter J,Mühl H

Fri Dec 07 00:00:00 EST 2012

Identifying functional microRNAs in macrophages with polarized phenotypes.

The Journal of biological chemistry

Graff JW,Dickson AM,Clay G,McCaffrey AP,Wilson ME

Fri Jun 22 00:00:00 EDT 2012

Molecular mimics of the tumour antigen MUC1.

PloS one

James TC,Bond U

Thu Jun 20 00:00:00 EDT 2013

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

Immunity

Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A

Fri Dec 23 00:00:00 EST 2011

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.

Blood

Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ

Thu Sep 01 00:00:00 EDT 2011

Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells.

Blood

Carlier J,Martin H,Mariamé B,Rauwel B,Mengelle C,Weclawiak H,Coaquette A,Vauchy C,Rohrlich P,Kamar N,Rostaing L,Herbein G,Davrinche C

Thu Dec 22 00:00:00 EST 2011

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.

The Journal of experimental medicine

Séror C,Melki MT,Subra F,Raza SQ,Bras M,Saïdi H,Nardacci R,Voisin L,Paoletti A,Law F,Martins I,Amendola A,Abdul-Sater AA,Ciccosanti F,Delelis O,Niedergang F,Thierry S,Said-Sadier N,Lamaze C,Métivier D,Estaquier J,Fimia GM,Falasca L,Casetti R,Modjtahedi N,Kanellopoulos J,Mouscadet JF,Ojcius DM,Piacentini M,Gougeon ML,Kroemer G,Perfettini JL

Mon Aug 29 00:00:00 EDT 2011

In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates.

The Journal of experimental medicine

Jung KC,Park CG,Jeon YK,Park HJ,Ban YL,Min HS,Kim EJ,Kim JH,Kang BH,Park SP,Bae Y,Yoon IH,Kim YH,Lee JI,Kim JS,Shin JS,Yang J,Kim SJ,Rostlund E,Muller WA,Park SH

Mon Nov 21 00:00:00 EST 2011

The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.

PLoS pathogens

Varga ZT,Ramos I,Hai R,Schmolke M,García-Sastre A,Fernandez-Sesma A,Palese P

Wed Jun 01 00:00:00 EDT 2011

Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms.

Stem cells (Dayton, Ohio)

Su WR,Zhang QZ,Shi SH,Nguyen AL,Le AD

Tue Nov 01 00:00:00 EDT 2011

Thymic stromal lymphopoietin is produced by dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Kashyap M,Rochman Y,Spolski R,Samsel L,Leonard WJ

Mon Aug 01 00:00:00 EDT 2011

Platelet-activating factor induces Th17 cell differentiation.

Mediators of inflammation

Drolet AM,Thivierge M,Turcotte S,Hanna D,Maynard B,Stankovà J,Rola-Pleszczynski M

Tue May 15 00:00:00 EDT 2012

Lipoglycans contribute to innate immune detection of mycobacteria.

PloS one

Krishna S,Ray A,Dubey SK,Larrouy-Maumus G,Chalut C,Castanier R,Noguera A,Gilleron M,Puzo G,Vercellone A,Nampoothiri KM,Nigou J

Fri Jul 20 00:00:00 EDT 2012

Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials.

Journal of translational medicine

Fučíková J,Rožková D,Ulčová H,Budinský V,Sochorová K,Pokorná K,Bartůňková J,Špíšek R

Fri Dec 30 00:00:00 EST 2011

The therapeutic effect of cytokine-induced killer cells on pancreatic cancer enhanced by dendritic cells pulsed with K-ras mutant peptide.

Clinical & developmental immunology

Tan G,Zhang X,Feng H,Luo H,Wang Z

Wed Jun 06 00:00:00 EDT 2012

KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation.

PloS one

Hanvesakul R,Kubal C,Moore J,Neil D,Cook M,Ball S,Briggs D,Moss P,Cockwell P

Fri Dec 23 00:00:00 EST 2011

Cytokine-based high log-scale expansion of functional human dendritic cells from cord-blood CD34-positive cells.

Scientific reports

Harada Y,Okada-Nakanishi Y,Ueda Y,Tsujitani S,Saito S,Fuji-Ogawa T,Iida A,Hasegawa M,Ichikawa T,Yonemitsu Y

Tue Sep 10 00:00:00 EDT 2013

Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells.

Journal of neuroinflammation

Dao MA,Tate CC,Aizman I,McGrogan M,Case CC

Fri Oct 07 00:00:00 EDT 2011

IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.

PloS one

Sammicheli S,Dang VP,Ruffin N,Pham HT,Lantto R,Vivar N,Chiodi F,Rethi B

Mon Aug 27 00:00:00 EDT 2012

Day-4 myeloid dendritic cells pulsed with whole tumor lysate are highly immunogenic and elicit potent anti-tumor responses.

PloS one

Chiang CL,Hagemann AR,Leskowitz R,Mick R,Garrabrant T,Czerniecki BJ,Kandalaft LE,Powell DJ,Coukos G

Mon Aug 27 00:00:00 EDT 2012

High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation.

PloS one

Maharjan AS,Pilling D,Gomer RH

Fri Feb 17 00:00:00 EST 2012

Bioinformatics

Protein Aliases: B cell growth factor 1; B-cell stimulatory factor 1; B_cell stimulatory factor 1; Binetrakin; BSF-1; H-IL-4; IL-4; ILN; Interleukin; interleukin 4 variant 2; Interleukin-4; Interleukin4; Lymphocyte stimulatory factor 1; M-IL-4; MGC79402; Pitrakinra

Human IL-4, Animal-Free Recombinant Protein, PeproTech®

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AF-200-04-20UG

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