Gibco

Human IL-4 Recombinant Protein, PeproTech®

Human IL-4 Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Human IL-4 Protein (200-04-20UG) in Functional

Bioassay analysis of Human IL-4 Recombinant Protein, PeproTech® (Product # 200-04-1MG).

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Product Details

200-04-20UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 7 publications 7 publications

Neutralization (Neu)

View 3 publications 3 publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 631 publications 631 publications

Miscellaneous PubMed (Misc)

View 54 publications 54 publications

Product Specifications

Species

Human

Published species

Chicken, Dog, Human, Mouse, Pig, Rabbit, Rat

Expression System

E. coli

Amino acid sequence

MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS

Molecular weight

15.1 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.

British journal of haematology

Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y

200-04 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.

Sat Jul 01 00:00:00 EDT 2023

Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion.

Cell death & disease

Capuz A,Osien S,Karnoub MA,Aboulouard S,Laurent E,Coyaud E,Raffo-Romero A,Duhamel M,Bonnefond A,Derhourhi M,Trerotola M,El Yazidi-Belkoura I,Devos D,Zilkova M,Kobeissy F,Vanden Abeele F,Fournier I,Cizkova D,Rodet F,Salzet M

200-04 was used in In vitro experiments to demonstrate that these chains are synthesized individually and associated to recognize specific targets.

Tue Apr 04 00:00:00 EDT 2023

Stereochemistry and functions of the new cysteinyl-resolvin, 4S,5R-RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes.

American journal of hematology

Nshimiyimana R,Libreros S,Simard M,Chiang N,Rodriguez AR,Spur BW,Haeggström JZ,Serhan CN

200-04 was used in Cell Culture to establish the complete stereochemistry of 4S,5R-RCTR1 as 5R-glutathionyl-4S,17S-dihydroxy-6E,8E,10Z,13Z,15E,19Z-docosahexaenoic acid and give evidence of its novel bioactivities in human phagocyte responses.

Sat Jul 01 00:00:00 EDT 2023

Identification of cross-reactive CD8⁺ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants.

Genes & diseases

Hu C,Shen M,Han X,Chen Q,Li L,Chen S,Zhang J,Gao F,Wang W,Wang Y,Li T,Li S,Huang J,Wang J,Zhu J,Chen D,Wu Q,Tao K,Pang D,Jin A

Sat Jan 01 00:00:00 EST 2022

Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid.

Immunology

Miek L,Jordan PM,Günther K,Pace S,Beyer T,Kowalak D,Hoerr V,Löffler B,Tuchscherr L,Serhan CN,Gerstmeier J,Werz O

Sun May 01 00:00:00 EDT 2022

Concurrent stimulation of monocytes with CSF1 and polarizing cytokines reveals phenotypic and functional differences with classical polarized macrophages.

Journal of leukocyte biology

An L,Michaeli J,Pallavi P,Breedijk A,Xu X,Dietrich N,Sigl M,Keese M,Nitschke K,Jarczyk J,Nuhn P,Krämer BK,Yard BA,Leipe J

Thu Sep 01 00:00:00 EDT 2022

Upregulation of CD3ζ and L-selectin in antigen-specific cytotoxic T lymphocytes by eliminating myeloid-derived suppressor cells with doxorubicin to improve killing efficacy of neuroblastoma cells in vitro.

Journal of clinical laboratory analysis

Xu W,Li S,Li M,Zhou H,Yang X

200-04 was used in Sample Preparation (FC/FACS) to investigate myeloid-derived suppressor cells in immunotherapy of cancer.

Sat Jan 01 00:00:00 EST 2022

Pyridoxamine ameliorates methylglyoxal-induced macrophage dysfunction to facilitate tissue repair in diabetic wounds.

International wound journal

Jiang M,Yakupu A,Guan H,Dong J,Liu Y,Song F,Tang J,Tian M,Niu Y,Lu S

Sat Jan 01 00:00:00 EST 2022

Sphingomyelin synthase 2 is a positive regulator of the CSF1R-STAT3 pathway in pancreatic cancer-associated macrophage.

Frontiers in pharmacology

He S,Gu X,Yang J,Xu F,Hu J,Wang W,Huang Y,Lou B,Ding T,Zhou L,Ye D,Yu K,Dong J

200-04 was used in Sample Preparation (Western Blotting) to study the role of sphingomyelin synthase 2 (SMS2) and the effect of the synthase 2 selective inhibitor YE2 in tumor-associated macrophage (TAMs) and the pancreatic tumor microenvironment.

Fri Nov 04 00:00:00 EDT 2022

Effects of macrophages on the proliferation and cardiac differentiation of human induced pluripotent stem cells.

Cell communication and signaling : CCS

Long C,Guo R,Han R,Li K,Wan Y,Xu J,Gong X,Zhao Y,Yao X,Liu J

200-04 was used in Cell Culture to study how macrophages affect the behavior of induced pluripotent stem cells (iPSCs) by generating three macrophage subtypes and assess their effects on the proliferation, cardiac differentiation, and maturation of iPSCs.

Mon Jul 18 00:00:00 EDT 2022

Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.

Cell reports

Li Y,Zhu Y,Feng S,Ishida Y,Chiu TP,Saito T,Wang S,Ann DK,Ou JJ

200-04 was used in Cell Culture to report that M1-like macrophages stimulated by HBV exhibit a strong HBV-suppressive effect, which is diminished in M2-like macrophages.

Tue Jan 25 00:00:00 EST 2022

Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent.

International journal of molecular sciences

Shephard MT,Merkhan MM,Forsyth NR

200-04 was used in In vitro experiments to investigate human mesenchymal stem cell secretions in treatment therapies.

Sun Nov 06 00:00:00 EDT 2022

Synthesis of bioactive (1→6)-β-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages.

Nature communications

Xiao R,Zeng J,Bressler EM,Lu W,Grinstaff MW

200-04 was used in In vitro experiments to proceed via the activation of NF-κB/AP-1 pathway in a Dectin-1-dependent manner, similar to natural β-glucans.

Tue Aug 09 00:00:00 EDT 2022

Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.

JID innovations : skin science from molecules to population health

Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH

200-04 was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.

Sat Jan 01 00:00:00 EST 2022

Exosomes derived from M2 macrophages induce angiogenesis to promote wound healing.

Frontiers in molecular biosciences

Lyu L,Cai Y,Zhang G,Jing Z,Liang J,Zhang R,Dang X,Zhang C

200-04 was used in Cell Culture to demonstrate that M2-EXO can be used as a promising nanomedicine strategy for therapeutic exploration of skin healing with the potential to be translated into clinical practice.

Sat Oct 29 00:00:00 EDT 2022

Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells.

Frontiers in immunology

Ng L,Wang X,Yang C,Su C,Li M,Cheung AKL

200-04 was used in Cell Culture to conclude that regulating the intracellular trafficking/processing of α-syn by DCs can be a potential approach to control the progression of PD, in which Celastrol is a potential candidate to accomplish this.

Mon May 02 00:00:00 EDT 2022

Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor-Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors.

Cancer immunology research

Kim SP,Vale NR,Zacharakis N,Krishna S,Yu Z,Gasmi B,Gartner JJ,Sindiri S,Malekzadeh P,Deniger DC,Lowery FJ,Parkhurst MR,Ngo LT,Ray S,Li YF,Hill V,Florentin M,Masi RV,Paria BC,Levin N,Bera A,Hedges EA,Choi A,Chatani PD,Parikh AY,Levi S,Seitter S,Lu YC,Zheng Z,Prickett TD,Jia L,Hernandez JM,Hoang CD,Robbins PF,Goff SL,Sherry RM,Yang JC,Rosenberg SA

200-04 was used in Cell Culture to suggest that the library of TCRs targeting shared p53 neoantigens should be further evaluated for the treatment of patients with advanced human cancers.

Wed Aug 03 00:00:00 EDT 2022

Nocardia rubra cell-wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells.

Cancer medicine

Zhang S,Wang H,Liu Y,Tao T,Zeng Z,Zhou Y,Wang M

200-04 was used in Cell Culture to suggest that Nr-CWS can promote apoptosis of cervical carcinoma cells by enhancing the antitumor effect of dendritic cells and macrophages.

Tue Mar 01 00:00:00 EST 2022

Indoleamine 2, 3-Dioxygenase 1 Mediates Survival Signals in Chronic Lymphocytic Leukemia via Kynurenine/Aryl Hydrocarbon Receptor-Mediated MCL1 Modulation.

Frontiers in immunology

Atene CG,Fiorcari S,Mesini N,Alboni S,Martinelli S,Maccaferri M,Leonardi G,Potenza L,Luppi M,Maffei R,Marasca R

200-04 was used in In vitro experiments to study the functional role of the IDO1/Kyn/AHR axis in chronic lymphocytic leukemia (CLL).

Fri Apr 08 00:00:00 EDT 2022

Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.

Cellular and molecular gastroenterology and hepatology

Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR

200-04 was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.

Mon Apr 04 00:00:00 EDT 2022

Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies.

Frontiers in pharmacology

Goldsteen PA,Sabogal Guaqueta AM,Mulder PPMFA,Bos IST,Eggens M,Van der Koog L,Soeiro JT,Halayko AJ,Mathwig K,Kistemaker LEM,Verpoorte EMJ,Dolga AM,Gosens R

200-04 was used in In vitro experiments to develop a microfluidic chip, to represent a human in vitro platform, to model neuro-effector interactions in the airways that may be used for mechanistic studies into neuroplasticity in asthma and other lung diseases.

Fri Nov 18 00:00:00 EST 2022

Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing.

iScience

Siriwach R,Ngo AQ,Higuchi M,Arima K,Sakamoto S,Watanabe A,Narumiya S,Thumkeo D

200-04 was used in Cell Culture to suggest that THBS1+ keratinocyte is a migratory keratinocyte subpopulation that facilitates epidermal wound healing.

Fri Apr 15 00:00:00 EDT 2022

MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization.

Scientific reports

Hansen LJ,Yang R,Roso K,Wang W,Chen L,Yang Q,Pirozzi CJ,He Y

200-04 was used in Cell Culture to investigate methylthioadenosine phosphorylase expression in glioblastoma.

Wed Mar 09 00:00:00 EST 2022

MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization.

Scientific reports

Hansen LJ,Yang R,Roso K,Wang W,Chen L,Yang Q,Pirozzi CJ,He Y

200-04 was used in Cell Culture to investigate methylthioadenosine phosphorylase expression in glioblastoma.

Wed Mar 09 00:00:00 EST 2022

Fam72a enforces error-prone DNA repair during antibody diversification.

Nature

Rogier M,Moritz J,Robert I,Lescale C,Heyer V,Abello A,Martin O,Capitani K,Thomas M,Thomas-Claudepierre AS,Laffleur B,Jouan F,Pinaud E,Tarte K,Cogné M,Conticello SG,Soutoglou E,Deriano L,Reina-San-Martin B

Wed Dec 01 00:00:00 EST 2021

The interferon landscape along the respiratory tract impacts the severity of COVID-19.

Cell

Sposito B,Broggi A,Pandolfi L,Crotta S,Clementi N,Ferrarese R,Sisti S,Criscuolo E,Spreafico R,Long JM,Ambrosi A,Liu E,Frangipane V,Saracino L,Bozzini S,Marongiu L,Facchini FA,Bottazzi A,Fossali T,Colombo R,Clementi M,Tagliabue E,Chou J,Pontiroli AE,Meloni F,Wack A,Mancini N,Zanoni I

Thu Sep 16 00:00:00 EDT 2021

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.

Cell

Sokal A,Chappert P,Barba-Spaeth G,Roeser A,Fourati S,Azzaoui I,Vandenberghe A,Fernandez I,Meola A,Bouvier-Alias M,Crickx E,Beldi-Ferchiou A,Hue S,Languille L,Michel M,Baloul S,Noizat-Pirenne F,Luka M,Mégret J,Ménager M,Pawlotsky JM,Fillatreau S,Rey FA,Weill JC,Reynaud CA,Mahévas M

Thu Mar 04 00:00:00 EST 2021

mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants.

Immunity

Sokal A,Barba-Spaeth G,Fernández I,Broketa M,Azzaoui I,de La Selle A,Vandenberghe A,Fourati S,Roeser A,Meola A,Bouvier-Alias M,Crickx E,Languille L,Michel M,Godeau B,Gallien S,Melica G,Nguyen Y,Zarrouk V,Canoui-Poitrine F,Pirenne F,Mégret J,Pawlotsky JM,Fillatreau S,Bruhns P,Rey FA,Weill JC,Reynaud CA,Chappert P,Mahévas M

Tue Dec 14 00:00:00 EST 2021

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.

Immunity

Ehx G,Larouche JD,Durette C,Laverdure JP,Hesnard L,Vincent K,Hardy MP,Thériault C,Rulleau C,Lanoix J,Bonneil E,Feghaly A,Apavaloaei A,Noronha N,Laumont CM,Delisle JS,Vago L,Hébert J,Sauvageau G,Lemieux S,Thibault P,Perreault C

Tue Apr 13 00:00:00 EDT 2021

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection.

Nature immunology

Munnur D,Teo Q,Eggermont D,Lee HHY,Thery F,Ho J,van Leur SW,Ng WWS,Siu LYL,Beling A,Ploegh H,Pinto-Fernandez A,Damianou A,Kessler B,Impens F,Mok CKP,Sanyal S

Mon Nov 01 00:00:00 EDT 2021

Selenium-GPX4 axis protects follicular helper T cells from ferroptosis.

Nature immunology

Yao Y,Chen Z,Zhang H,Chen C,Zeng M,Yunis J,Wei Y,Wan Y,Wang N,Zhou M,Qiu C,Zeng Q,Ong HS,Wang H,Makota FV,Yang Y,Yang Z,Wang N,Deng J,Shen C,Xia Y,Yuan L,Lian Z,Deng Y,Guo C,Huang A,Zhou P,Shi H,Zhang W,Yi H,Li D,Xia M,Fu J,Wu N,de Haan JB,Shen N,Zhang W,Liu Z,Yu D

Wed Sep 01 00:00:00 EDT 2021

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.

Cell stem cell

Shah PP,Lv W,Rhoades JH,Poleshko A,Abbey D,Caporizzo MA,Linares-Saldana R,Heffler JG,Sayed N,Thomas D,Wang Q,Stanton LJ,Bedi K,Morley MP,Cappola TP,Owens AT,Margulies KB,Frank DB,Wu JC,Rader DJ,Yang W,Prosser BL,Musunuru K,Jain R

200-04 was used in Cell Culture to show that pathogenic LAMIN A/C variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.

Thu May 06 00:00:00 EDT 2021

Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis.

The Journal of clinical investigation

Furlong-Silva J,Cross SD,Marriott AE,Pionnier N,Archer J,Steven A,Merker SS,Mack M,Hong YK,Taylor MJ,Turner JD

Mon Mar 01 00:00:00 EST 2021

Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus.

The Journal of clinical investigation

Vlahava VM,Murrell I,Zhuang L,Aicheler RJ,Lim E,Miners KL,Ladell K,Suárez NM,Price DA,Davison AJ,Wilkinson GW,Wills MR,Weekes MP,Wang EC,Stanton RJ

Mon Feb 15 00:00:00 EST 2021

TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis.

The Journal of clinical investigation

Jiang Z,Lim SO,Yan M,Hsu JL,Yao J,Wei Y,Chang SS,Yamaguchi H,Lee HH,Ke B,Hsu JM,Chan LC,Hortobagyi GN,Yang L,Lin C,Yu D,Hung MC

Thu Apr 15 00:00:00 EDT 2021

Human skin is colonized by T cells that recognize CD1a independently of lipid.

The Journal of clinical investigation

Cotton RN,Cheng TY,Wegrecki M,Le Nours J,Orgill DP,Pomahac B,Talbot SG,Willis RA,Altman JD,de Jong A,Ogg G,Van Rhijn I,Rossjohn J,Clark RA,Moody DB

Mon Jan 04 00:00:00 EST 2021

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.

The Journal of experimental medicine

Pieters T,T'Sas S,Vanhee S,Almeida A,Driege Y,Roels J,Van Loocke W,Daneels W,Baens M,Marchand A,Van Trimpont M,Matthijssens F,Morscio J,Lemeire K,Lintermans B,Reunes L,Chaltin P,Offner F,Van Dorpe J,Hochepied T,Berx G,Beyaert R,Staal J,Van Vlierberghe P,Goossens S

Mon Oct 04 00:00:00 EDT 2021

T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients.

The Journal of experimental medicine

Kuehn HS,Chang J,Yamashita M,Niemela JE,Zou C,Okuyama K,Harada J,Stoddard JL,Nunes-Santos CJ,Boast B,Baxter RM,Hsieh EWY,Garofalo M,Fleisher TA,Morio T,Taniuchi I,Dutmer CM,Rosenzweig SD

Mon Dec 06 00:00:00 EST 2021

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.

The Journal of experimental medicine

Lu X,Hosono Y,Nagae M,Ishizuka S,Ishikawa E,Motooka D,Ozaki Y,Sax N,Maeda Y,Kato Y,Morita T,Shinnakasu R,Inoue T,Onodera T,Matsumura T,Shinkai M,Sato T,Nakamura S,Mori S,Kanda T,Nakayama EE,Shioda T,Kurosaki T,Takeda K,Kumanogoh A,Arase H,Nakagami H,Yamashita K,Takahashi Y,Yamasaki S

Mon Dec 06 00:00:00 EST 2021

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι.

Proceedings of the National Academy of Sciences of the United States of America

Zhang Y,Chen Y,Li Y,Huang F,Luo B,Yuan Y,Xia B,Ma X,Yang T,Yu F,Liu J,Liu B,Song Z,Chen J,Yan S,Wu L,Pan T,Zhang X,Li R,Huang W,He X,Xiao F,Zhang J,Zhang H

Tue Jun 08 00:00:00 EDT 2021

Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation.

Cell death and differentiation

Snodgrass RG,Benatzy Y,Schmid T,Namgaladze D,Mainka M,Schebb NH,Lütjohann D,Brüne B

Thu Apr 01 00:00:00 EDT 2021

The Fibronectin-ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells.

Cancer immunology research

Paavola KJ,Roda JM,Lin VY,Chen P,O'Hollaren KP,Ventura R,Crawley SC,Li B,Chen HH,Malmersjö S,Sharkov NA,Horner G,Guo W,Kutach AK,Mondal K,Zhang Z,Lichtman JS,Song C,Rivera LB,Liu W,Luo J,Wang Y,Solloway MJ,Allan BB,Kekatpure A,Starck SR,Haldankar R,Fan B,Chu C,Tang J,Molgora M,Colonna M,Kaplan DD,Hsu JY

200-04 was used in In vitro experiments to show that, by blocking this interaction, tumor-associated myeloid cells may acquire a stimulatory phenotype, potentially resulting in increased antitumor T-cell responses.

Mon Nov 01 00:00:00 EDT 2021

lncRNA-Xist/miR-101-3p/KLF6/C/EBPα axis promotes TAM polarization to regulate cancer cell proliferation and migration.

Molecular therapy. Nucleic acids

Zhao Y,Yu Z,Ma R,Zhang Y,Zhao L,Yan Y,Lv X,Zhang L,Su P,Bi J,Xu H,He M,Wei M

Fri Mar 05 00:00:00 EST 2021

Severe Acute Respiratory Syndrome Coronavirus 2-Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells.

The Journal of infectious diseases

Zheng J,Wang Y,Li K,Meyerholz DK,Allamargot C,Perlman S

Wed Mar 03 00:00:00 EST 2021

Mantle cell lymphoma polarizes tumor-associated macrophages into M2-like macrophages, which in turn promote tumorigenesis.

Blood advances

Le K,Sun J,Khawaja H,Shibata M,Maggirwar SB,Smith MR,Gupta M

Tue Jul 27 00:00:00 EDT 2021

CXCL5 secreted from macrophages during cold exposure mediates white adipose tissue browning.

Journal of lipid research

Lee D,Kim DW,Yoon S,Nam AR,Lee KH,Nam KH,Cho SM,Yoon Y,Cho JY

Thu Mar 24 00:00:00 EDT 2022

Enhanced Uptake of Processed Bovine β-Lactoglobulin by Antigen Presenting Cells: Identification of Receptors and Implications for Allergenicity.

Molecular nutrition & food research

Teodorowicz M,Zenker HE,Ewaz A,Tsallis T,Mauser A,Gensberger-Reigl S,de Jong NW,Hettinga KA,Wichers HJ,van Neerven RJJ,Savelkoul HFJ

Thu Apr 01 00:00:00 EDT 2021

Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.

Cancer science

Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K

200-04 was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.

Mon Feb 01 00:00:00 EST 2021

Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.

Cancer science

Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K

Mon Feb 01 00:00:00 EST 2021

Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes.

Molecular therapy oncolytics

Labani-Motlagh A,Naseri S,Wenthe J,Eriksson E,Loskog A

Fri Mar 26 00:00:00 EDT 2021

Mycobacterium leprae induces a tolerogenic profile in monocyte-derived dendritic cells via TLR2 induction of IDO.

Journal of leukocyte biology

Oliveira JAP,Gandini M,Sales JS,Fujimori SK,Barbosa MGM,Frutuoso VS,Moraes MO,Sarno EN,Pessolani MCV,Pinheiro RO

Thu Jul 01 00:00:00 EDT 2021

TPL Inhibits the Invasion and Migration of Drug-Resistant Ovarian Cancer by Targeting the PI3K/AKT/NF-κB-Signaling Pathway to Inhibit the Polarization of M2 TAMs.

Frontiers in oncology

Le F,Yang L,Han Y,Zhong Y,Zhan F,Feng Y,Hu H,Chen T,Tan B

200-04 was used in Cell Culture to highlight the importance of M2 TAMs in Epithelial Ovarian Cancer (EOC) migration ability, invasiveness, and resistance to DDP.

Fri Aug 13 00:00:00 EDT 2021

IL-21 Is an Accomplice of PD-L1 in the Induction of PD-1-Dependent Treg Generation in Head and Neck Cancer.

Frontiers in oncology

Zhao Y,Zhang Z,Lei W,Wei Y,Ma R,Wen Y,Wei F,Fan J,Xu Y,Chen L,Lyu K,Lin H,Wen W,Sun W

200-04 was used in Cell Culture to study that IL-21 could promote PD-L1-induced Treg generation in a PD-1-dependent manner.

Wed May 26 00:00:00 EDT 2021

T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette-Guérin Vaccination.

Journal of immunology (Baltimore, Md. : 1950)

Layton ED,Barman S,Wilburn DB,Yu KKQ,Smith MT,Altman JD,Scriba TJ,Tahiri N,Minnaard AJ,Roederer M,Seder RA,Darrah PA,Seshadri C

Mon Mar 15 00:00:00 EDT 2021

Proinflammatory Features of Stem Cell-like Memory T Cells from Human Patients with Rheumatoid Arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Lee YJ,Park EH,Park JW,Jung KC,Lee EB

Thu Jul 15 00:00:00 EDT 2021

CD40L-Stimulated B Lymphocytes Are Polarized toward APC Functions after Exposure to IL-4 and IL-21.

Journal of immunology (Baltimore, Md. : 1950)

Possamaï D,Pagé G,Panès R,Gagnon É,Lapointe R

Thu Jul 01 00:00:00 EDT 2021

Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β.

Journal of immunology (Baltimore, Md. : 1950)

Allaeys I,Ribeiro de Vargas F,Bourgoin SG,Poubelle PE

Thu Apr 15 00:00:00 EDT 2021

The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Xie B,Khoyratty TE,Abu-Shah E,F Cespedes P,MacLean AJ,Pirgova G,Hu Z,Ahmed AA,Dustin ML,Udalova IA,Arnon TI

Thu Apr 01 00:00:00 EDT 2021

Selective inhibition of prostaglandin D₂ biosynthesis in human mast cells to overcome need for multiple receptor antagonists: Biochemical consequences.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Johnsson AK,Choi JH,Rönnberg E,Fuchs D,Kolmert J,Hamberg M,Dahlén B,Wheelock CE,Dahlén SE,Nilsson G

Thu Apr 01 00:00:00 EDT 2021

Dendritic cells loaded with exosomes derived from cancer stem cell-enriched spheroids as a potential immunotherapeutic option.

Journal of cellular and molecular medicine

Naseri M,Zöller M,Hadjati J,Ghods R,Ranaei Pirmardan E,Kiani J,Eini L,Bozorgmehr M,Madjd Z

Thu Apr 01 00:00:00 EDT 2021

Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway.

Journal of cellular and molecular medicine

Hu J,Wang J,Li C,Shang Y

Tue Jun 01 00:00:00 EDT 2021

Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization.

Journal of cellular and molecular medicine

Liu Y,Du M,Lin HY

Sun Aug 01 00:00:00 EDT 2021

HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.

Stem cells international

Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS

Tue Jun 08 00:00:00 EDT 2021

Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.

Transfusion

Cunningham S,Hackstein H

Tue Jun 01 00:00:00 EDT 2021

Endocytosed nanogold fiducials for improved in-situ cryo-electron tomography tilt-series alignment.

Journal of structural biology

Berger C,Ravelli RBG,López-Iglesias C,Peters PJ

200-04 was used in Cell Culture to describe a method to allow uptake of bovine serum albumin (BSA)-gold fiducials into mammalian cells via endocytosis, which can subsequently be used as fiducials for tilt-series alignment of cryo-focused ion beam (FIB) lamellae.

Mon Mar 01 00:00:00 EST 2021

ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.

Cell reports

Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J

Tue Aug 24 00:00:00 EDT 2021

Ruxolitinib inhibits poly(I:C) and type 2 cytokines-induced CCL5 production in bronchial epithelial cells: A potential therapeutic agent for severe eosinophilic asthma.

Immunity, inflammation and disease

Sada M,Watanabe M,Inui T,Nakamoto K,Hirata A,Nakamura M,Honda K,Saraya T,Kurai D,Kimura H,Ishii H,Takizawa H

Tue Jun 01 00:00:00 EDT 2021

Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2^pos Breast Cancer.

International journal of breast cancer

Ghimirey N,Steele C,Czerniecki BJ,Koski GK,Showalter LE

Tue May 04 00:00:00 EDT 2021

SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression.

Nature communications

Hou G,Harley ITW,Lu X,Zhou T,Xu N,Yao C,Qin Y,Ouyang Y,Ma J,Zhu X,Yu X,Xu H,Dai D,Ding H,Yin Z,Ye Z,Deng J,Zhou M,Tang Y,Namjou B,Guo Y,Weirauch MT,Kottyan LC,Harley JB,Shen N

Fri Jan 08 00:00:00 EST 2021

Implication of TIGIT⁺ human memory B cells in immune regulation.

Nature communications

Hasan MM,Nair SS,O'Leary JG,Thompson-Snipes L,Nyarige V,Wang J,Park W,Stegall M,Heilman R,Klintmalm GB,Joo H,Oh S

Tue Mar 09 00:00:00 EST 2021

Inhibition of galectin-3 augments the antitumor efficacy of PD-L1 blockade in non-small-cell lung cancer.

FEBS open bio

Zhang H,Liu P,Zhang Y,Han L,Hu Z,Cai Z,Cai J

Mon Mar 01 00:00:00 EST 2021

The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.

Cell reports

Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H

Tue Apr 27 00:00:00 EDT 2021

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.

Cell reports

Trauelsen M,Hiron TK,Lin D,Petersen JE,Breton B,Husted AS,Hjorth SA,Inoue A,Frimurer TM,Bouvier M,O'Callaghan CA,Schwartz TW

Tue Jun 15 00:00:00 EDT 2021

IL-25 Induced ROS-Mediated M2 Macrophage Polarization via AMPK-Associated Mitophagy.

International journal of molecular sciences

Tsai ML,Tsai YG,Lin YC,Hsu YL,Chen YT,Tsai MK,Liao WT,Lin YC,Hung CH

200-04 was used in Cell Culture to induce mitophagy to stimulate M2 macrophage polarization in monocytes.

Tue Dec 21 00:00:00 EST 2021

Pseurotin D Inhibits the Activation of Human Lymphocytes.

International journal of molecular sciences

Rubanova D,Dadova P,Vasicek O,Kubala L

200-04 was used in Cell Culture to perform complex characterization of the effects of pseurotin D on human lymphocyte activation to understand the potential of pseurotin to modulate immune response in humans.

Tue Feb 16 00:00:00 EST 2021

Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.

Nature communications

Renner K,Schwittay T,Chaabane S,Gottschling J,Müller C,Tiefenböck C,Salewski JN,Winter F,Buchtler S,Balam S,Malfertheiner MV,Lubnow M,Lunz D,Graf B,Hitzenbichler F,Hanses F,Poeck H,Kreutz M,Orsó E,Burkhardt R,Niedermair T,Brochhausen C,Gessner A,Salzberger B,Mack M

Fri May 21 00:00:00 EDT 2021

A novel, multitargeted endogenous metabolic modulator composition impacts metabolism, inflammation, and fibrosis in nonalcoholic steatohepatitis-relevant primary human cell models.

Scientific reports

Daou N,Viader A,Cokol M,Nitzel A,Chakravarthy MV,Afeyan R,Tramontin T,Marukian S,Hamill MJ

Fri Jun 04 00:00:00 EDT 2021

Titanium Nanoparticles Enhance Production and Suppress Stabilin-1-Mediated Clearance of GDF-15 in Human Primary Macrophages.

Frontiers in immunology

Silva-Bermudez LS,Sevastyanova TN,Schmuttermaier C,De La Torre C,Schumacher L,Klüter H,Kzhyshkowska J

200-04 was used in In vitro experiments to study how titanium nanoparticles (TiNPs) affect the healing activities of macrophages and their release of circulating cytokines to identify the transcriptional program induced and suppressed by TiNPs in human pro-inflammatory and healing macrophages.

Wed Feb 16 00:00:00 EST 2022

M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.

Frontiers in immunology

Li L,Wei K,Ding Y,Ahati P,Xu H,Fang H,Wang H

200-04 was used in Cell Culture to investigate M2a expression during intervertebral disc degeneration.

Thu Oct 14 00:00:00 EDT 2021

Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids.

Journal for immunotherapy of cancer

Hamdan F,Ylösmäki E,Chiaro J,Giannoula Y,Long M,Fusciello M,Feola S,Martins B,Feodoroff M,Antignani G,Russo S,Kari O,Lee M,Järvinen P,Nisen H,Kreutzman A,Leusen J,Mustjoki S,McWilliams TG,Grönholm M,Cerullo V

200-04 was used in Cell Culture to designed an oncolytic adenovirus to increase efficacy while minimizing toxicity of PD-L1 immunecheckpoint therapy that secretes a cross-hybrid Fc-fusion peptide against PD-L1 able to elicit effector mechanisms of an IgG1 and also IgA1 consequently activating neutrophils, a population neglected by IgG1, in order to combine multiple effector mechanisms.

Sun Aug 01 00:00:00 EDT 2021

Identification of HLA-A2-Restricted Mutant Epitopes from Neoantigens of Esophageal Squamous Cell Carcinoma.

Vaccines

Wang Z,Ran L,Chen C,Shi R,Dong Y,Li Y,Zhou X,Qi Y,Zhu P,Gao Y,Wu Y

200-04 was used in Sample Preparation (FC/FACS) to investigate treatment for esophageal squamous cell carcinoma.

Fri Oct 01 00:00:00 EDT 2021

Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.

Nature communications

Wang J,Wang J,Hong W,Zhang L,Song L,Shi Q,Shao Y,Hao G,Fang C,Qiu Y,Yang L,Yang Z,Wang J,Cao J,Yang B,He Q,Weng Q

Wed Oct 27 00:00:00 EDT 2021

Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen.

Scientific reports

Miebach L,Freund E,Horn S,Niessner F,Sagwal SK,von Woedtke T,Emmert S,Weltmann KD,Clemen R,Schmidt A,Gerling T,Bekeschus S

Fri Jan 08 00:00:00 EST 2021

Functional and genomic adaptations of blood monocytes to pregravid obesity during pregnancy.

iScience

Sureshchandra S,Marshall NE,Mendoza N,Jankeel A,Zulu MZ,Messaoudi I

Fri Jun 25 00:00:00 EDT 2021

Biomimetic Anti-PD-1 Peptide-Loaded 2D FePSe₃ Nanosheets for Efficient Photothermal and Enhanced Immune Therapy with Multimodal MR/PA/Thermal Imaging.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Fang X,Wu X,Li Z,Jiang L,Lo WS,Chen G,Gu Y,Wong WT

Fri Jan 01 00:00:00 EST 2021

Chemotherapy agents stimulate dendritic cells against human colon cancer cells through upregulation of the transporter associated with antigen processing.

Scientific reports

Liang YH,Tsai JH,Cheng YM,Chan KY,Hsu WL,Lee CC,Chen KH,Yeh KH

Tue Apr 27 00:00:00 EDT 2021

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.

Cell reports. Medicine

Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN

Tue Apr 20 00:00:00 EDT 2021

Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity.

Cell reports

Szodoray P,Andersen TK,Heinzelbecker J,Imbery JF,Huszthy PC,Stanford SM,Bogen B,Landsverk OB,Bottini N,Tveita A,Munthe LA,Nakken B

Tue Aug 10 00:00:00 EDT 2021

Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.

Nature communications

Wang YC,Wang X,Yu J,Ma F,Li Z,Zhou Y,Zeng S,Ma X,Li YR,Neal A,Huang J,To A,Clarke N,Memarzadeh S,Pellegrini M,Yang L

Thu Jun 10 00:00:00 EDT 2021

Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants.

Communications biology

Cavarelli M,Hua S,Hantour N,Tricot S,Tchitchek N,Gommet C,Hocini H,Chapon C,Dereuddre-Bosquet N,Le Grand R

Mon Jul 12 00:00:00 EDT 2021

Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages.

Cell discovery

Lv J,Wang Z,Qu Y,Zhu H,Zhu Q,Tong W,Bao L,Lv Q,Cong J,Li D,Deng W,Yu P,Song J,Tong WM,Liu J,Liu Y,Qin C,Huang B

Tue Apr 13 00:00:00 EDT 2021

SARS-CoV-2 Induces Lymphocytopenia by Promoting Inflammation and Decimates Secondary Lymphoid Organs.

Frontiers in immunology

Xiang Q,Feng Z,Diao B,Tu C,Qiao Q,Yang H,Zhang Y,Wang G,Wang H,Wang C,Liu L,Wang C,Liu L,Chen R,Wu Y,Chen Y

200-04 was used in In vitro experiments to demonstrate that SARS-CoV-2 induced lymphocytopenia by promoting systemic inflammation and direct neutralization in human spleen and LNs.

Tue May 25 00:00:00 EDT 2021

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.

Nature communications

Conde E,Bertrand R,Balbino B,Bonnefoy J,Stackowicz J,Caillot N,Colaone F,Hamdi S,Houmadi R,Loste A,Kamphuis JBJ,Huetz F,Guilleminault L,Gaudenzio N,Mougel A,Hardy D,Snouwaert JN,Koller BH,Serra V,Bruhns P,Grouard-Vogel G,Reber LL

Tue May 11 00:00:00 EDT 2021

Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression.

Nature communications

Bolis M,Bossi D,Vallerga A,Ceserani V,Cavalli M,Impellizzieri D,Di Rito L,Zoni E,Mosole S,Elia AR,Rinaldi A,Pereira Mestre R,D'Antonio E,Ferrari M,Stoffel F,Jermini F,Gillessen S,Bubendorf L,Schraml P,Calcinotto A,Corey E,Moch H,Spahn M,Thalmann G,Kruithof-de Julio M,Rubin MA,Theurillat JP

200-04 was used in In vitro experiments to provide a user-friendly web-resource enabling the investigation of dynamic transcriptional perturbations linked to disease progression.

Thu Dec 02 00:00:00 EST 2021

Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis.

Nature communications

Andres-Ejarque R,Ale HB,Grys K,Tosi I,Solanky S,Ainali C,Catak Z,Sreeneebus H,Saklatvala J,Dand N,de Rinaldis E,Chapman A,Nestle FO,Barnes MR,Warren RB,Reynolds NJ,Griffiths CEM,Barker JN,Smith CH,Di Meglio P

Fri Aug 06 00:00:00 EDT 2021

Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.

Communications biology

Hou XX,Wang XQ,Zhou WJ,Li DJ

Fri Apr 23 00:00:00 EDT 2021

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.

Nature communications

Koerner J,Horvath D,Herrmann VL,MacKerracher A,Gander B,Yagita H,Rohayem J,Groettrup M

200-04 was used in Cell Culture to demonstrate the supreme adjuvant effect of the recently developed and pharmaceutically defined double-stranded (ds)RNA adjuvant Riboxxim especially when incorporated into PLGA particles.

Tue May 18 00:00:00 EDT 2021

Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.

The Journal of clinical investigation

Zheng J,Meyerholz D,Wong LR,Gelb M,Murakami M,Perlman S

Tue Jun 01 00:00:00 EDT 2021

High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.

Nature communications

Hu G,Su Y,Kang BH,Fan Z,Dong T,Brown DR,Cheah J,Wittrup KD,Chen J

Wed Feb 03 00:00:00 EST 2021

PD-1 Affects the Immunosuppressive Function of Group 2 Innate Lymphoid Cells in Human Non-Small Cell Lung Cancer.

Frontiers in immunology

Shen C,Liu C,Zhang Z,Ping Y,Shao J,Tian Y,Yu W,Qin G,Liu S,Wang L,Zhang Y

200-04 was used in Sample Preparation (FC/FACS) to show that ILC2s are enriched in NSCLC patients and upregulate PD-1 expression.

Mon Oct 25 00:00:00 EDT 2021

Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages.

Cancers

Jang SD,Song J,Kim HA,Im CN,Khawar IA,Park JK,Kuh HJ

200-04 was used in Cell Culture to analyse the anti-cancer effects of activated pancreatic stellate cells and M2 macrophages in pancreatic ductal adenocarcinoma.

Fri Nov 26 00:00:00 EST 2021

Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells.

Nature communications

Xing J,Zhang A,Du Y,Fang M,Minze LJ,Liu YJ,Li XC,Zhang Z

Tue May 11 00:00:00 EDT 2021

Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells.

Nature communications

Xing J,Zhang A,Du Y,Fang M,Minze LJ,Liu YJ,Li XC,Zhang Z

Tue May 11 00:00:00 EDT 2021

Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.

Frontiers in immunology

Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP

200-04 was used in Cell Culture to investigate whether Cytochrome P450 26A1 (CYP26A1) regulates the polarization of uterine macrophages in early pregnancy.

Thu Feb 10 00:00:00 EST 2022

Ultra-purification of Lipopolysaccharides reveals species-specific signalling bias of TLR4: importance in macrophage function.

Scientific reports

Stephens M,Liao S,von der Weid PY

Thu Jan 14 00:00:00 EST 2021

Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation.

Science immunology

Niyonzima N,Rahman J,Kunz N,West EE,Freiwald T,Desai JV,Merle NS,Gidon A,Sporsheim B,Lionakis MS,Evensen K,Lindberg B,Skagen K,Skjelland M,Singh P,Haug M,Ruseva MM,Kolev M,Bibby J,Marshall O,O'Brien B,Deeks N,Afzali B,Clark RJ,Woodruff TM,Pryor M,Yang ZH,Remaley AT,Mollnes TE,Hewitt SM,Yan B,Kazemian M,Kiss MG,Binder CJ,Halvorsen B,Espevik T,Kemper C

200-04 was used in Sample Preparation (Western Blotting) to suggest that the complosome is a contributor to the biologic processes underlying sterile inflammation and indicate that targeting this system could be beneficial in macrophage-dependent diseases, such as atherosclerosis.

Fri Dec 24 00:00:00 EST 2021

Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity.

Cell

Lu Y,Zhao Q,Liao JY,Song E,Xia Q,Pan J,Li Y,Li J,Zhou B,Ye Y,Di C,Yu S,Zeng Y,Su S

Thu Mar 19 00:00:00 EDT 2020

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.

Cell

Blanco-Melo D,Nilsson-Payant BE,Liu WC,Uhl S,Hoagland D,Møller R,Jordan TX,Oishi K,Panis M,Sachs D,Wang TT,Schwartz RE,Lim JK,Albrecht RA,tenOever BR

Thu May 28 00:00:00 EDT 2020

Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans.

Cell

Ha CWY,Martin A,Sepich-Poore GD,Shi B,Wang Y,Gouin K,Humphrey G,Sanders K,Ratnayake Y,Chan KSL,Hendrick G,Caldera JR,Arias C,Moskowitz JE,Ho Sui SJ,Yang S,Underhill D,Brady MJ,Knott S,Kaihara K,Steinbaugh MJ,Li H,McGovern DPB,Knight R,Fleshner P,Devkota S

Thu Oct 29 00:00:00 EDT 2020

Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.

Cell

Devalaraja S,To TKJ,Folkert IW,Natesan R,Alam MZ,Li M,Tada Y,Budagyan K,Dang MT,Zhai L,Lobel GP,Ciotti GE,Eisinger-Mathason TSK,Asangani IA,Weber K,Simon MC,Haldar M

200-04 was used in In vitro experiments to find that the TME induces tumor cells to produce retinoic acid (RA), which polarizes intratumoral monocyte differentiation toward TAMs and away from DCs via suppression of DC-promoting transcription factor Irf4.

Thu Mar 19 00:00:00 EDT 2020

Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses.

Immunity

Ma X,Zou F,Yu F,Li R,Yuan Y,Zhang Y,Zhang X,Deng J,Chen T,Song Z,Qiao Y,Zhan Y,Liu J,Zhang J,Zhang X,Peng Z,Li Y,Lin Y,Liang L,Wang G,Chen Y,Chen Q,Pan T,He X,Zhang H

200-04 was used in Flow cytometry/Cell sorting to develop nanoparticle vaccines by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spike (S) protein.

Tue Dec 15 00:00:00 EST 2020

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.

Cancer cell

Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J

Mon Jul 13 00:00:00 EDT 2020

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.

Blood

Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE

Thu Aug 06 00:00:00 EDT 2020

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer.

The Journal of clinical investigation

Cafri G,Gartner JJ,Zaks T,Hopson K,Levin N,Paria BC,Parkhurst MR,Yossef R,Lowery FJ,Jafferji MS,Prickett TD,Goff SL,McGowan CT,Seitter S,Shindorf ML,Parikh A,Chatani PD,Robbins PF,Rosenberg SA

Mon Nov 02 00:00:00 EST 2020

Trans-endocytosis of intact IL-15Rα-IL-15 complex from presenting cells into NK cells favors signaling for proliferation.

Proceedings of the National Academy of Sciences of the United States of America

Anton OM,Peterson ME,Hollander MJ,Dorward DW,Arora G,Traba J,Rajagopalan S,Snapp EL,Garcia KC,Waldmann TA,Long EO

Tue Jan 07 00:00:00 EST 2020

A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.

Proceedings of the National Academy of Sciences of the United States of America

Ramanathan A,Weintraub M,Orlovetskie N,Serruya R,Mani D,Marcu O,Stepensky P,Weisblum Y,Djian E,Shaag A,Revel-Vilk S,Fried I,Kotler M,Rouvinski A,Wolf D,Elpeleg O,Jarrous N

Tue Sep 08 00:00:00 EDT 2020

Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease.

Proceedings of the National Academy of Sciences of the United States of America

Preciado-Llanes L,Aulicino A,Canals R,Moynihan PJ,Zhu X,Jambo N,Nyirenda TS,Kadwala I,Sousa Gerós A,Owen SV,Jambo KC,Kumwenda B,Veerapen N,Besra GS,Gordon MA,Hinton JCD,Napolitani G,Salio M,Simmons A

Tue Aug 25 00:00:00 EDT 2020

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.

Proceedings of the National Academy of Sciences of the United States of America

Cribbs AP,Terlecki-Zaniewicz S,Philpott M,Baardman J,Ahern D,Lindow M,Obad S,Oerum H,Sampey B,Mander PK,Penn H,Wordsworth P,Bowness P,de Winther M,Prinjha RK,Feldmann M,Oppermann U

Tue Mar 17 00:00:00 EDT 2020

Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.

Science signaling

Gómez V,Eykyn TR,Mustapha R,Flores-Borja F,Male V,Barber PR,Patsialou A,Green R,Panagaki F,Li CW,Fruhwirth GO,Ros S,Brindle KM,Ng T

Tue Oct 06 00:00:00 EDT 2020

High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1.

EMBO reports

Steins A,van Mackelenbergh MG,van der Zalm AP,Klaassen R,Serrels B,Goris SG,Kocher HM,Waasdorp C,de Jong JH,Tekin C,Besselink MG,Busch OR,van de Vijver MJ,Verheij J,Dijk F,van Tienhoven G,Wilmink JW,Medema JP,van Laarhoven HW,Bijlsma MF

Wed May 06 00:00:00 EDT 2020

Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis.

Clinical and translational medicine

Strack E,Rolfe PA,Fink AF,Bankov K,Schmid T,Solbach C,Savai R,Sha W,Pradel L,Hartmann S,Brüne B,Weigert A

Tue Dec 01 00:00:00 EST 2020

Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy.

Cancer immunology, immunotherapy : CII

Thomas R,Shaath H,Naik A,Toor SM,Elkord E,Decock J

200-04 was used in In vitro experiments to investigate the immunogenicity of LDHC using T cells from healthy individuals.

Sun Mar 01 00:00:00 EST 2020

Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid.

Frontiers in molecular neuroscience

Spampinato SF,Merlo S,Fagone E,Fruciano M,Sano Y,Kanda T,Sortino MA

200-04 was used in Cell Culture to show reciprocal crosstalk between infiltrating peripheral cells and astrocytes upon Aβ exposure.

Mon Sep 28 00:00:00 EDT 2020

Resident alveolar macrophage-derived vesicular SOCS3 dampens allergic airway inflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Draijer C,Speth JM,Penke LRK,Zaslona Z,Bazzill JD,Lugogo N,Huang YJ,Moon JJ,Peters-Golden M

Sun Mar 01 00:00:00 EST 2020

A human co-culture cell model incorporating microglia supports glioblastoma growth and migration, and confers resistance to cytotoxics.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Leite DM,Zvar Baskovic B,Civita P,Neto C,Gumbleton M,Pilkington GJ

Wed Jan 01 00:00:00 EST 2020

Activation of Human Vδ2⁺ γδ T Cells by Staphylococcus aureus Promotes Enhanced Anti-Staphylococcal Adaptive Immunity.

Journal of immunology (Baltimore, Md. : 1950)

Cooper AJR,Lalor SJ,McLoughlin RM

Sat Aug 15 00:00:00 EDT 2020

Homeostatic Milieu Induces Production of Deoxyribonuclease 1-like 3 from Myeloid Cells.

Journal of immunology (Baltimore, Md. : 1950)

Inokuchi S,Mitoma H,Kawano S,Nakano S,Ayano M,Kimoto Y,Akahoshi M,Arinobu Y,Tsukamoto H,Akashi K,Horiuchi T,Niiro H

Wed Apr 15 00:00:00 EDT 2020

Human CD8⁺ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses.

Journal of immunology (Baltimore, Md. : 1950)

Abu-Shah E,Trendel N,Kruger P,Nguyen J,Pettmann J,Kutuzov M,Dushek O

Tue Sep 15 00:00:00 EDT 2020

MRGPRX2 activation as a rapid, high-throughput mechanistic-based approach for detecting peptide-mediated human mast cell degranulation liabilities.

Journal of immunotoxicology

Lafleur MA,Werner J,Fort M,Lobenhofer EK,Balazs M,Goyos A

200-04 was used in Sample Preparation (FC/FACS) to investigate the use of assessing MRGPRX2 activation in engineered cells in screening for mast cell degranulation for peptide-based therapeutics.

Tue Dec 01 00:00:00 EST 2020

Inhibition of thymic stromal lymphopoietin production to improve pruritus and quality of life in infants and children with atopic dermatitis.

Journal of cosmetic dermatology

Fitoussi J,Virassamynaïk S,Callejon S,Weber S,Collet E,Scalia J,Chavagnac-Bonneville M,Trompezinski S,Sayag M

Sat Aug 01 00:00:00 EDT 2020

hESC-derived immune suppressive dendritic cells induce immune tolerance of parental hESC-derived allografts.

EBioMedicine

Todorova D,Zhang Y,Chen Q,Liu J,He J,Fu X,Xu Y

200-04 was used in Cell Culture to investigate whether the adoptive transfer of CTLA4-Ig/PD-L1 knock-in dendritic cell-like cells(CP DCLs) can induce long-term immune tolerance of parental human embryonic stem cells(hESC)-derived smooth muscle and cardiomyocyte allografts.

Tue Dec 01 00:00:00 EST 2020

Immunomodulatory activity of IR700-labelled affibody targeting HER2.

Cell death & disease

Mączyńska J,Da Pieve C,Burley TA,Raes F,Shah A,Saczko J,Harrington KJ,Kramer-Marek G

Tue Oct 20 00:00:00 EDT 2020

Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate-Novel Insights.

Cancers

Povo-Retana A,Mojena M,Stremtan AB,Fernández-García VB,Gómez-Sáez A,Nuevo-Tapioles C,Molina-Guijarro JM,Avendaño-Ortiz J,Cuezva JM,López-Collazo E,Martínez-Leal JF,Boscá L

200-04 was used in In vitro experiments to study the effect of trabectedin and lurbinectedin on human macrophage cell viability and function.

Tue Oct 20 00:00:00 EDT 2020

Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage.

The Journal of biological chemistry

Jobin PG,Solis N,Machado Y,Bell PA,Rai SK,Kwon NH,Kim S,Overall CM,Butler GS

Fri Feb 21 00:00:00 EST 2020

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.

Nature communications

Ma J,Wei K,Liu J,Tang K,Zhang H,Zhu L,Chen J,Li F,Xu P,Chen J,Liu J,Fang H,Tang L,Wang D,Zeng L,Sun W,Xie J,Liu Y,Huang B

Tue Apr 14 00:00:00 EDT 2020

Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation.

Cell death & disease

Deng L,Li H,Su X,Zhang Y,Xu H,Fan L,Fan J,Han Q,Bai X,Zhao RC

Mon Mar 02 00:00:00 EST 2020

Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation.

FASEB bioAdvances

Aki A,Tanaka K,Nagaoka N,Kimura T,Baba D,Onodera Y,Wada T,Maeda H,Nakanishi T,Agatsuma T,Komai T

Sat Aug 01 00:00:00 EDT 2020

Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma.

Nature communications

Tao W,Chu C,Zhou W,Huang Z,Zhai K,Fang X,Huang Q,Zhang A,Wang X,Yu X,Huang H,Wu Q,Sloan AE,Yu JS,Li X,Stark GR,Rich JN,Bao S

Mon Jun 15 00:00:00 EDT 2020

Endogenous antisense RNA curbs CD39 expression in Crohn's disease.

Nature communications

Harshe RP,Xie A,Vuerich M,Frank LA,Gromova B,Zhang H,Robles RJ,Mukherjee S,Csizmadia E,Kokkotou E,Cheifetz AS,Moss AC,Kota SK,Robson SC,Longhi MS

Wed Nov 18 00:00:00 EST 2020

In vivo non-invasive staining-free visualization of dermal mast cells in healthy, allergy and mastocytosis humans using two-photon fluorescence lifetime imaging.

Scientific reports

Kröger M,Scheffel J,Nikolaev VV,Shirshin EA,Siebenhaar F,Schleusener J,Lademann J,Maurer M,Darvin ME

Thu Sep 10 00:00:00 EDT 2020

Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice.

Nature communications

Zuo B,Qi H,Lu Z,Chen L,Sun B,Yang R,Zhang Y,Liu Z,Gao X,You A,Wu L,Jing R,Zhou Q,Yin H

Tue Apr 14 00:00:00 EDT 2020

Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule.

Cell reports. Medicine

Berezhnoy A,Sumrow BJ,Stahl K,Shah K,Liu D,Li J,Hao SS,De Costa A,Kaul S,Bendell J,Cote GM,Luke JJ,Sanborn RE,Sharma MR,Chen F,Li H,Diedrich G,Bonvini E,Moore PA

200-04 was used in Cell Culture to conclude that MGD019 demonstrates encouraging activity in tumors traditionally unresponsive to checkpoint blockade.

Tue Dec 22 00:00:00 EST 2020

Autologous apoptotic neutrophils inhibit inflammatory cytokine secretion by human dendritic cells, but enhance Th1 responses.

FEBS open bio

Majai GE,Gogolák P,Tóth M,Hodrea J,Horváth D,Fésüs L,Rajnavölgyi É,Bácsi A

Sat Aug 01 00:00:00 EDT 2020

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution.

Cell reports

Jordan PM,Gerstmeier J,Pace S,Bilancia R,Rao Z,Börner F,Miek L,Gutiérrez-Gutiérrez Ó,Arakandy V,Rossi A,Ialenti A,González-Estévez C,Löffler B,Tuchscherr L,Serhan CN,Werz O

200-04 was used in In vitro experiments to investigate the role of α-hemolysin from Staphylococcus aureus in the activation of specialized pro-resolving mediators.

Tue Oct 13 00:00:00 EDT 2020

RPTPε promotes M2-polarized macrophage migration through ROCK2 signaling and podosome formation.

Journal of cell science

Lapointe F,Turcotte S,Roy J,Bissonnette E,Rola-Pleszczynski M,Stankova J

200-04 was used in Cell Culture to show that differentiation and polarization of monocytes into M2-polarized hMDMs modulates the expression of PTPε isoforms and RPTPε is involved in podosome distribution, ROCK2 activation and migration in response to LTD4.

Tue Jan 21 00:00:00 EST 2020

T Cell Receptor Engineered Lymphocytes for Cancer Therapy.

Current protocols in immunology

Rollins MR,Spartz EJ,Stromnes IM

200-04 was used in Cell Culture to synthesize and expand upon methodologies to generate, isolate, and engineer human T cells with tumor-reactive TCRs for adoptive cell therapy.

Mon Jun 01 00:00:00 EDT 2020

The regulatory role of PGC1α-related coactivator in response to drug-induced liver injury.

FASEB bioAdvances

Buler M,Naessens T,Mattsson J,Morias Y,Söderberg M,Robbins P,Kärrberg L,Svensson TS,Thulin P,Glinghammar B,Scarpulla RC,Andersson U

Sat Aug 01 00:00:00 EDT 2020

Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.

Frontiers in immunology

Korvatska O,Kiianitsa K,Ratushny A,Matsushita M,Beeman N,Chien WM,Satoh JI,Dorschner MO,Keene CD,Bammler TK,Bird TD,Raskind WH

200-04 was used in Cell Culture to point to a role of the TREM2 receptor in the control of the interferon type I response in myeloid cells and provide insight regarding the contribution of R47H TREM2 to AD pathology.

Fri Apr 30 00:00:00 EDT 2021

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.

Proceedings of the National Academy of Sciences of the United States of America

Scholz F,Grau M,Menzel L,Graband A,Zapukhlyak M,Leutz A,Janz M,Lenz G,Rehm A,Höpken UE

Tue Oct 20 00:00:00 EDT 2020

Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells.

Scientific reports

Kaur K,Ko MW,Ohanian N,Cook J,Jewett A

Mon Nov 23 00:00:00 EST 2020

Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation.

Nature communications

Li ZL,Zhang HL,Huang Y,Huang JH,Sun P,Zhou NN,Chen YH,Mai J,Wang Y,Yu Y,Zhou LH,Li X,Yang D,Peng XD,Feng GK,Tang J,Zhu XF,Deng R

Thu Jul 30 00:00:00 EDT 2020

CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation.

Scientific reports

Elmetwali T,Salman A,Wei W,Hussain SA,Young LS,Palmer DH

Wed Jan 15 00:00:00 EST 2020

Intact B-Cell Signaling and Function With Host B-Cells 47 Years After Transplantation for X-SCID.

Frontiers in immunology

Deal C,Thauland TJ,Stiehm ER,Garcia-Lloret MI,Butte MJ

200-04 was used in Sample Preparation (FC/FACS) to demonstrate that satisfactory B-cell function can arise as a consequence of both intact IL-21 signaling due to a hypomorphic γc variant, and close HLA matching with the donor to allow for effective T-cell help.

Mon Mar 08 00:00:00 EST 2021

Immunogenic neoantigens derived from gene fusions stimulate T cell responses.

Nature medicine

Yang W,Lee KW,Srivastava RM,Kuo F,Krishna C,Chowell D,Makarov V,Hoen D,Dalin MG,Wexler L,Ghossein R,Katabi N,Nadeem Z,Cohen MA,Tian SK,Robine N,Arora K,Geiger H,Agius P,Bouvier N,Huberman K,Vanness K,Havel JJ,Sims JS,Samstein RM,Mandal R,Tepe J,Ganly I,Ho AL,Riaz N,Wong RJ,Shukla N,Chan TA,Morris LGT

200-04 was used in Cell Culture to study the gene fusions as a source of immunogenic neoantigens that can mediate responses to immunotherapy.

Wed May 01 00:00:00 EDT 2019

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.

Cell

Georgouli M,Herraiz C,Crosas-Molist E,Fanshawe B,Maiques O,Perdrix A,Pandya P,Rodriguez-Hernandez I,Ilieva KM,Cantelli G,Karagiannis P,Mele S,Lam H,Josephs DH,Matias-Guiu X,Marti RM,Nestle FO,Orgaz JL,Malanchi I,Fruhwirth GO,Karagiannis SN,Sanz-Moreno V

Thu Feb 07 00:00:00 EST 2019

Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.

Cell

Watanabe A,McCarthy KR,Kuraoka M,Schmidt AG,Adachi Y,Onodera T,Tonouchi K,Caradonna TM,Bajic G,Song S,McGee CE,Sempowski GD,Feng F,Urick P,Kepler TB,Takahashi Y,Harrison SC,Kelsoe G

Thu May 16 00:00:00 EDT 2019

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.

Immunity

Zhao Y,Lee CK,Lin CH,Gassen RB,Xu X,Huang Z,Xiao C,Bonorino C,Lu LF,Bui JD,Hui E

Tue Dec 17 00:00:00 EST 2019

The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.

Immunity

Kusnadi A,Park SH,Yuan R,Pannellini T,Giannopoulou E,Oliver D,Lu T,Park-Min KH,Ivashkiv LB

Tue Aug 20 00:00:00 EDT 2019

Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils.

Immunity

Takeda A,Hollmén M,Dermadi D,Pan J,Brulois KF,Kaukonen R,Lönnberg T,Boström P,Koskivuo I,Irjala H,Miyasaka M,Salmi M,Butcher EC,Jalkanen S

Tue Sep 17 00:00:00 EDT 2019

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.

Immunity

Schwartz DM,Farley TK,Richoz N,Yao C,Shih HY,Petermann F,Zhang Y,Sun HW,Hayes E,Mikami Y,Jiang K,Davis FP,Kanno Y,Milner JD,Siegel R,Laurence A,Meylan F,O'Shea JJ

Tue Jan 15 00:00:00 EST 2019

Low-dose chidamide restores immune tolerance in ITP in mice and humans.

Blood

Zhao HY,Ma YH,Li DQ,Sun T,Li LZ,Li P,Liu XG,Zhou H,Hou Y,Liu Y,Han PP,Zhao YJ,Jing FM,Peng J,Hou M

Thu Feb 14 00:00:00 EST 2019

Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.

Cell stem cell

Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L

200-04 was used in Sample Preparation (FC/FACS) to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.

Thu Oct 03 00:00:00 EDT 2019

Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors.

The Journal of clinical investigation

Chen F,Zou Z,Du J,Su S,Shao J,Meng F,Yang J,Xu Q,Ding N,Yang Y,Liu Q,Wang Q,Sun Z,Zhou S,Du S,Wei J,Liu B

Wed May 01 00:00:00 EDT 2019

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes.

The Journal of clinical investigation

Gros A,Tran E,Parkhurst MR,Ilyas S,Pasetto A,Groh EM,Robbins PF,Yossef R,Garcia-Garijo A,Fajardo CA,Prickett TD,Jia L,Gartner JJ,Ray S,Ngo L,Wunderllich JR,Yang JC,Rosenberg SA

Fri Nov 01 00:00:00 EDT 2019

Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade.

Science translational medicine

Shekarian T,Sivado E,Jallas AC,Depil S,Kielbassa J,Janoueix-Lerosey I,Hutter G,Goutagny N,Bergeron C,Viari A,Valsesia-Wittmann S,Caux C,Marabelle A

200-04 was used in Sample Preparation (FC/FACS) to study whether anti-infectious disease vaccines could be used as a commercially available source of immunostimulatory agents for cancer immunotherapy.

Wed Oct 23 00:00:00 EDT 2019

Regulatory roles of IL-10-producing human follicular T cells.

The Journal of experimental medicine

Cañete PF,Sweet RA,Gonzalez-Figueroa P,Papa I,Ohkura N,Bolton H,Roco JA,Cuenca M,Bassett KJ,Sayin I,Barry E,Lopez A,Canaday DH,Meyer-Hermann M,Doglioni C,Fazekas de St Groth B,Sakaguchi S,Cook MC,Vinuesa CG

Mon Aug 05 00:00:00 EDT 2019

Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.

The Journal of experimental medicine

Deng M,Guo H,Tam JW,Johnson BM,Brickey WJ,New JS,Lenox A,Shi H,Golenbock DT,Koller BH,McKinnon KP,Beutler B,Ting JP

Mon Dec 02 00:00:00 EST 2019

Mycobacterium tuberculosis releases an antacid that remodels phagosomes.

Nature chemical biology

Buter J,Cheng TY,Ghanem M,Grootemaat AE,Raman S,Feng X,Plantijn AR,Ennis T,Wang J,Cotton RN,Layre E,Ramnarine AK,Mayfield JA,Young DC,Jezek Martinot A,Siddiqi N,Wakabayashi S,Botella H,Calderon R,Murray M,Ehrt S,Snider BB,Reed MB,Oldfield E,Tan S,Rubin EJ,Behr MA,van der Wel NN,Minnaard AJ,Moody DB

200-04 was used in Sample Preparation (FC/FACS) to study how Mycobacterium tuberculosis (Mtb)-produced 1-tuberculosinyladenosine (1-TbAd) is a naturally evolved phagolysosome disruptor.

Sun Sep 01 00:00:00 EDT 2019

Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells.

Proceedings of the National Academy of Sciences of the United States of America

Bedard M,Shrestha D,Priestman DA,Wang Y,Schneider F,Matute JD,Iyer SS,Gileadi U,Prota G,Kandasamy M,Veerapen N,Besra G,Fritzsche M,Zeissig S,Shevchenko A,Christianson JC,Platt FM,Eggeling C,Blumberg RS,Salio M,Cerundolo V

Tue Nov 19 00:00:00 EST 2019

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation.

Aging cell

Hu B,Li G,Ye Z,Gustafson CE,Tian L,Weyand CM,Goronzy JJ

Thu Aug 01 00:00:00 EDT 2019

M2 macrophages mediate sorafenib resistance by secreting HGF in a feed-forward manner in hepatocellular carcinoma.

British journal of cancer

Dong N,Shi X,Wang S,Gao Y,Kuang Z,Xie Q,Li Y,Deng H,Wu Y,Li M,Li JL

Mon Jul 01 00:00:00 EDT 2019

Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.

British journal of cancer

Chen Q,Wang J,Zhang Q,Zhang J,Lou Y,Yang J,Chen Y,Wei T,Zhang J,Fu Q,Ye M,Zhang X,Dang X,Liang T,Bai X

Tue Oct 01 00:00:00 EDT 2019

ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism.

Mucosal immunology

Fang R,Uchiyama R,Sakai S,Hara H,Tsutsui H,Suda T,Mitsuyama M,Kawamura I,Tsuchiya K

Sun Sep 01 00:00:00 EDT 2019

Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages.

European journal of immunology

Maeda A,Digifico E,Andon FT,Mantovani A,Allavena P

Wed May 01 00:00:00 EDT 2019

Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation.

Cancer science

Harada K,Ihara F,Takami M,Kamata T,Mise N,Yoshizawa H,Hishiki T,Saito T,Terui K,Nakata M,Komatsu S,Ikeuchi T,Nakayama T,Yoshida H,Motohashi S

Fri Mar 01 00:00:00 EST 2019

Vascular endothelial growth factor (VEGF) impairs the motility and immune function of human mature dendritic cells through the VEGF receptor 2-RhoA-cofilin1 pathway.

Cancer science

Long J,Hu Z,Xue H,Wang Y,Chen J,Tang F,Zhou J,Liu L,Qiu W,Zhang S,Ouyang Y,Ye Y,Xu G,Li L,Zeng Z

Thu Aug 01 00:00:00 EDT 2019

dPGS Regulates the Phenotype of Macrophages via Metabolic Switching.

Macromolecular bioscience

Wu H,Reimann S,Siddiqui S,Haag R,Siegmund B,Dernedde J,Glauben R

Sun Dec 01 00:00:00 EST 2019

Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts.

Journal of immunology (Baltimore, Md. : 1950)

Krishnamurthy A,Ytterberg AJ,Sun M,Sakuraba K,Steen J,Joshua V,Tarasova NK,Malmström V,Wähämaa H,Réthi B,Catrina AI

Sat Jun 01 00:00:00 EDT 2019

Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer.

Journal of immunology (Baltimore, Md. : 1950)

Biswas S,Mandal G,Roy Chowdhury S,Purohit S,Payne KK,Anadon C,Gupta A,Swanson P,Yu X,Conejo-Garcia JR,Bhattacharyya A

Sun Dec 15 00:00:00 EST 2019

Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer.

Journal of immunology (Baltimore, Md. : 1950)

Leko V,McDuffie LA,Zheng Z,Gartner JJ,Prickett TD,Apolo AB,Agarwal PK,Rosenberg SA,Lu YC

Sat Jun 15 00:00:00 EDT 2019

Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses.

Journal of immunology (Baltimore, Md. : 1950)

Onodera T,Hashi K,Shukla RK,Miki M,Takai-Todaka R,Fujimoto A,Kuraoka M,Miyoshi T,Kobayashi K,Hasegawa H,Ato M,Kelsoe G,Katayama K,Takahashi Y

Sun Dec 15 00:00:00 EST 2019

Synergy between B cell receptor/antigen uptake and MHCII peptide editing relies on HLA-DO tuning.

Scientific reports

Jiang W,Adler LN,Macmillan H,Mellins ED

Wed Sep 25 00:00:00 EDT 2019

Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.

Nature communications

Ziegler JF,Böttcher C,Letizia M,Yerinde C,Wu H,Freise I,Rodriguez-Sillke Y,Stoyanova AK,Kreis ME,Asbach P,Kunkel D,Priller J,Anagnostopoulos I,Kühl AA,Miehle K,Stumvoll M,Tran F,Fredrich B,Forster M,Franke A,Bojarski C,Glauben R,Löscher BS,Siegmund B,Weidinger C

Tue Dec 10 00:00:00 EST 2019

Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC.

Frontiers in immunology

Oda H,Beck DB,Kuehn HS,Sampaio Moura N,Hoffmann P,Ibarra M,Stoddard J,Tsai WL,Gutierrez-Cruz G,Gadina M,Rosenzweig SD,Kastner DL,Notarangelo LD,Aksentijevich I

200-04 was used in In vitro experiments to identify a genetic cause of a disease for an 8 year-old girl who presented with early-onset immune deficiency and autoinflammation.

Thu Sep 10 00:00:00 EDT 2020

Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter.

The Journal of biological chemistry

Dupont L,Du L,Poulter M,Choi S,McIntosh M,Reeves MB

Fri Aug 30 00:00:00 EDT 2019

The citrus flavonoid naringenin impairs the in vitro infection of human cells by Zika virus.

Scientific reports

Cataneo AHD,Kuczera D,Koishi AC,Zanluca C,Silveira GF,Arruda TB,Suzukawa AA,Bortot LO,Dias-Baruffi M,Verri WA,Robert AW,Stimamiglio MA,Duarte Dos Santos CN,Wowk PF,Bordignon J

Fri Nov 08 00:00:00 EST 2019

A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer.

Cell death & disease

Mazzoldi EL,Pavan S,Pilotto G,Leone K,Pagotto A,Frezzini S,Nicoletto MO,Amadori A,Pastò A

Tue May 28 00:00:00 EDT 2019

Engineering of anti-human interleukin-4 receptor alpha antibodies with potent antagonistic activity.

Scientific reports

Kim JE,Jung K,Kim JA,Kim SH,Park HS,Kim YS

Thu May 23 00:00:00 EDT 2019

In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay.

Scientific reports

Schulz D,Severin Y,Zanotelli VRT,Bodenmiller B

Wed Feb 13 00:00:00 EST 2019

Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase.

The Journal of biological chemistry

Jobin PG,Solis N,Machado Y,Bell PA,Kwon NH,Kim S,Overall CM,Butler GS

Fri Aug 30 00:00:00 EDT 2019

The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway.

Cell death & disease

Ye Z,Zhong L,Zhu S,Wang Y,Zheng J,Wang S,Zhang J,Huang R

Mon Jul 01 00:00:00 EDT 2019

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma.

Nature communications

Czystowska-Kuzmicz M,Sosnowska A,Nowis D,Ramji K,Szajnik M,Chlebowska-Tuz J,Wolinska E,Gaj P,Grazul M,Pilch Z,Zerrouqi A,Graczyk-Jarzynka A,Soroczynska K,Cierniak S,Koktysz R,Elishaev E,Gruca S,Stefanowicz A,Blaszczyk R,Borek B,Gzik A,Whiteside T,Golab J

Fri Jul 05 00:00:00 EDT 2019

Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.

Nature communications

Adachi Y,Tonouchi K,Nithichanon A,Kuraoka M,Watanabe A,Shinnakasu R,Asanuma H,Ainai A,Ohmi Y,Yamamoto T,Ishii KJ,Hasegawa H,Takeyama H,Lertmemongkolchai G,Kurosaki T,Ato M,Kelsoe G,Takahashi Y

Wed Aug 28 00:00:00 EDT 2019

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation.

Frontiers in immunology

Lara-Reyna S,Scambler T,Holbrook J,Wong C,Jarosz-Griffiths HH,Martinon F,Savic S,Peckham D,McDermott MF

200-04 was used in Cell Culture to investigate signalling pathways following cystic fibrosis transmembrane conductance regulator mutations.

Tue Oct 13 00:00:00 EDT 2020

Transforming growth factor β1 alters the 3'-UTR of mRNA to promote lung fibrosis.

The Journal of biological chemistry

Ko J,Mills T,Huang J,Chen NY,Mertens TCJ,Collum SD,Lee G,Xiang Y,Han L,Zhou Y,Lee CG,Elias JA,Jyothula SSK,Rajagopal K,Karmouty-Quintana H,Blackburn MR

Fri Oct 25 00:00:00 EDT 2019

Erythromycin suppresses neutrophil extracellular traps in smoking-related chronic pulmonary inflammation.

Cell death & disease

Zhang H,Qiu SL,Tang QY,Zhou X,Zhang JQ,He ZY,Bai J,Li MH,Deng JM,Liang Y,Zhong XN

Thu Sep 12 00:00:00 EDT 2019

iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer.

Nature communications

Ding N,Zou Z,Sha H,Su S,Qian H,Meng F,Chen F,Du S,Zhou S,Chen H,Zhang L,Yang J,Wei J,Liu B

Fri Mar 22 00:00:00 EDT 2019

Non-thermal plasma inhibits mast cell activation and ameliorates allergic skin inflammatory diseases in NC/Nga mice.

Scientific reports

Lee MH,Lee YS,Kim HJ,Han CH,Kang SU,Kim CH

Wed Sep 18 00:00:00 EDT 2019

A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells.

eLife

Abu-Shah E,Demetriou P,Bálint Š,Mayya V,Kutuzov MA,Dushek O,Dustin ML

200-04 was used in Cell Culture to report a tissue-like system that recapitulates the dynamics of engineered primary human immune cell and characterise unique dynamics of T-cell/DC interactions as a function of antigen affinity.

Wed Sep 25 00:00:00 EDT 2019

Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion.

Science advances

Johnston JM,Angyal A,Bauer RC,Hamby S,Suvarna SK,Baidžajevas K,Hegedus Z,Dear TN,Turner M,Wilson HL,Goodall AH,Rader DJ,Shoulders CC,Francis SE,Kiss-Toth E

200-04 was used in Cell Culture to suggest that a conserved, TRIB1-mediated mechanism drives foam cell formation in atherosclerotic plaque and that inhibiting mTRIB1 could be used therapeutically to reduce CHD.

Tue Oct 01 00:00:00 EDT 2019

ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12.

Cell death & disease

Kloss L,Dollt C,Schledzewski K,Krewer A,Melchers S,Manta C,Sticht C,Torre C,Utikal J,Umansky V,Schmieder A

Mon Oct 07 00:00:00 EDT 2019

Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients.

Nature communications

Cafri G,Yossef R,Pasetto A,Deniger DC,Lu YC,Parkhurst M,Gartner JJ,Jia L,Ray S,Ngo LT,Jafferji M,Sachs A,Prickett T,Robbins PF,Rosenberg SA

Fri Jan 25 00:00:00 EST 2019

LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization.

Cell death & disease

Liang ZX,Liu HS,Wang FW,Xiong L,Zhou C,Hu T,He XW,Wu XJ,Xie D,Wu XR,Lan P

Mon Nov 04 00:00:00 EST 2019

Senescence-associated reprogramming promotes cancer stemness.

Nature

Milanovic M,Fan DNY,Belenki D,Däbritz JHM,Zhao Z,Yu Y,Dörr JR,Dimitrova L,Lenze D,Monteiro Barbosa IA,Mendoza-Parra MA,Kanashova T,Metzner M,Pardon K,Reimann M,Trumpp A,Dörken B,Zuber J,Gronemeyer H,Hummel M,Dittmar G,Lee S,Schmitt CA

Thu Jan 04 00:00:00 EST 2018

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Cell

Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E

Thu Oct 04 00:00:00 EDT 2018

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Cell

Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S

Thu May 31 00:00:00 EDT 2018

Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.

Immunity

McCarthy KR,Watanabe A,Kuraoka M,Do KT,McGee CE,Sempowski GD,Kepler TB,Schmidt AG,Kelsoe G,Harrison SC

Tue Jan 16 00:00:00 EST 2018

Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.

Cell host & microbe

Johnson JS,Lucas SY,Amon LM,Skelton S,Nazitto R,Carbonetti S,Sather DN,Littman DR,Aderem A

200-04 was used in Cell Culture to study how dendritic cells (DCs) detect HIV-1 in distinct phases, before and after virus integration in response to reverse transcription.

Wed Mar 14 00:00:00 EDT 2018

Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease.

The Journal of clinical investigation

Mao L,Kitani A,Similuk M,Oler AJ,Albenberg L,Kelsen J,Aktay A,Quezado M,Yao M,Montgomery-Recht K,Fuss IJ,Strober W

Tue May 01 00:00:00 EDT 2018

MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.

The Journal of clinical investigation

Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q

Fri Jun 01 00:00:00 EDT 2018

MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.

The Journal of clinical investigation

Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q

Fri Jun 01 00:00:00 EDT 2018

Spatial distribution and function of T follicular regulatory cells in human lymph nodes.

The Journal of experimental medicine

Sayin I,Radtke AJ,Vella LA,Jin W,Wherry EJ,Buggert M,Betts MR,Herati RS,Germain RN,Canaday DH

Mon Jun 04 00:00:00 EDT 2018

Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies.

Clinical cancer research : an official journal of the American Association for Cancer Research

L'Italien L,Orozco O,Abrams T,Cantagallo L,Connor A,Desai J,Ebersbach H,Gelderblom H,Hoffmaster K,Lees E,Maacke H,Schleyer S,Skegro D,Lee-Hoeflich ST

200-04 was used in In vitro experiments to identifying potential mitigation strategies in hypersensitivity reactions.

Sun Jul 15 00:00:00 EDT 2018

Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice.

Proceedings of the National Academy of Sciences of the United States of America

Raimondo TM,Mooney DJ

Tue Oct 16 00:00:00 EDT 2018

Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice.

Proceedings of the National Academy of Sciences of the United States of America

Raimondo TM,Mooney DJ

Tue Oct 16 00:00:00 EDT 2018

Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin.

Proceedings of the National Academy of Sciences of the United States of America

Plugis NM,Weng N,Zhao Q,Palanski BA,Maecker HT,Habtezion A,Khosla C

Tue Aug 28 00:00:00 EDT 2018

Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin.

Proceedings of the National Academy of Sciences of the United States of America

Plugis NM,Weng N,Zhao Q,Palanski BA,Maecker HT,Habtezion A,Khosla C

Tue Aug 28 00:00:00 EDT 2018

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.

Frontiers in immunology

Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M

200-04 was used in In vitro experiments to compare the efficacy of dendritic cell receptor-ligand blockades at various immune checkpoints on T cell activation, an suggest targets for enhanced immunotherapy.

Mon Apr 08 00:00:00 EDT 2019

Lymphatic exosomes promote dendritic cell migration along guidance cues.

The Journal of cell biology

Brown M,Johnson LA,Leone DA,Majek P,Vaahtomeri K,Senfter D,Bukosza N,Schachner H,Asfour G,Langer B,Hauschild R,Parapatics K,Hong YK,Bennett KL,Kain R,Detmar M,Sixt M,Jackson DG,Kerjaschki D

Mon Jun 04 00:00:00 EDT 2018

Infection with flaviviruses requires BCLXL for cell survival.

PLoS pathogens

Suzuki T,Okamoto T,Katoh H,Sugiyama Y,Kusakabe S,Tokunaga M,Hirano J,Miyata Y,Fukuhara T,Ikawa M,Satoh T,Yoshio S,Suzuki R,Saijo M,Huang DCS,Kanto T,Akira S,Matsuura Y

200-04 was used in In vitro experiments to suggest that BCLXL plays a crucial role in the survival of cells infected with flaviviruses, and that BCLXL may provide a novel antiviral target to suppress propagation of the family of Flaviviridae viruses.

Sat Sep 01 00:00:00 EDT 2018

Increased infiltration of macrophages to radioresistant lung cancer cells contributes to the development of the additional resistance of tumor cells to the cytotoxic effects of NK cells.

International journal of oncology

Shen M,Chen Y,Xu L,Zhu R,Xue X,Tsai Y,Keng PC,Lee SO,Chen Y

200-04 was used in Cell Culture to suggest the existence of a malignant loop characterized by increased macrophage infiltration into radioresistant lung cancer cells which, in turn, promotes the development of the additional resistance of these cells to NK cell cytotoxicity.

Sun Jul 01 00:00:00 EDT 2018

Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells.

Journal of immunology (Baltimore, Md. : 1950)

Otsuka Y,Watanabe E,Shinya E,Okura S,Saeki H,Geijtenbeek TBH,Takahashi H

Thu Nov 15 00:00:00 EST 2018

Toll-like Receptor 4-Induced Glycolytic Burst in Human Monocyte-Derived Dendritic Cells Results from p38-Dependent Stabilization of HIF-1α and Increased Hexokinase II Expression.

Journal of immunology (Baltimore, Md. : 1950)

Perrin-Cocon L,Aublin-Gex A,Diaz O,Ramière C,Peri F,André P,Lotteau V

Sat Sep 01 00:00:00 EDT 2018

Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis.

Journal of immunology (Baltimore, Md. : 1950)

Singh T,Fakiola M,Oommen J,Singh AP,Singh AK,Smith N,Chakravarty J,Sundar S,Blackwell JM

Sun Apr 15 00:00:00 EDT 2018

Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells.

Journal of immunology (Baltimore, Md. : 1950)

Paupert J,Espinosa E,Cenac N,Robert V,Laharrague P,Evrard SM,Casteilla L,Lorsignol A,Cousin B

Sat Dec 15 00:00:00 EST 2018

Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Ringleb J,Strack E,Angioni C,Geisslinger G,Steinhilber D,Weigert A,Brüne B

Mon Jan 15 00:00:00 EST 2018

Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.

Journal of immunology (Baltimore, Md. : 1950)

Zhang W,Kim H,Lv J,Zhao N,Ma X

Thu Feb 15 00:00:00 EST 2018

BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation.

Journal of cellular and molecular medicine

Pardali E,Makowski LM,Leffers M,Borgscheiper A,Waltenberger J

Thu Nov 01 00:00:00 EDT 2018

GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.

Nature communications

Offenbacher S,Jiao Y,Kim SJ,Marchesan J,Moss KL,Jing L,Divaris K,Bencharit S,Agler CS,Morelli T,Zhang S,Sun L,Seaman WT,Cowley D,Barros SP,Beck JD,Munz M,Schaefer AS,North KE

Tue Sep 11 00:00:00 EDT 2018

Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells.

Emerging microbes & infections

Sirmarova J,Salat J,Palus M,Hönig V,Langhansova H,Holbrook MR,Ruzek D

Wed Nov 07 00:00:00 EST 2018

Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.

Scientific reports

Silvola JMU,Li XG,Virta J,Marjamäki P,Liljenbäck H,Hytönen JP,Tarkia M,Saunavaara V,Hurme S,Palani S,Hakovirta H,Ylä-Herttuala S,Saukko P,Chen Q,Low PS,Knuuti J,Saraste A,Roivainen A

Tue Jun 26 00:00:00 EDT 2018

Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets.

Nature communications

Aulicino A,Rue-Albrecht KC,Preciado-Llanes L,Napolitani G,Ashley N,Cribbs A,Koth J,Lagerholm BC,Ambrose T,Gordon MA,Sims D,Simmons A

Mon Nov 19 00:00:00 EST 2018

CXCL1 derived from tumor-associated macrophages promotes breast cancer metastasis via activating NF-κB/SOX4 signaling.

Cell death & disease

Wang N,Liu W,Zheng Y,Wang S,Yang B,Li M,Song J,Zhang F,Zhang X,Wang Q,Wang Z

Wed Aug 29 00:00:00 EDT 2018

CXCL1 derived from tumor-associated macrophages promotes breast cancer metastasis via activating NF-κB/SOX4 signaling.

Cell death & disease

Wang N,Liu W,Zheng Y,Wang S,Yang B,Li M,Song J,Zhang F,Zhang X,Wang Q,Wang Z

Wed Aug 29 00:00:00 EDT 2018

A conserved enhancer regulates Il9 expression in multiple lineages.

Nature communications

Koh B,Abdul Qayum A,Srivastava R,Fu Y,Ulrich BJ,Janga SC,Kaplan MH

Thu Nov 15 00:00:00 EST 2018

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion.

Cell reports

Gkirtzimanaki K,Kabrani E,Nikoleri D,Polyzos A,Blanas A,Sidiropoulos P,Makrigiannakis A,Bertsias G,Boumpas DT,Verginis P

200-04 was used in Cell Culture to demonstrate IFNα-mediated deregulation of mitochondrial metabolism and impairment of autophagic degradation, leading to cytosolic accumulation of mtDNA that is sensed via stimulator of interferon genes (STING) to promote induction of autoinflammatory DCs.

Tue Oct 23 00:00:00 EDT 2018

A malaria protein factor induces IL-4 production by dendritic cells via PI3K-Akt-NF-κB signaling independent of MyD88/TRIF and promotes Th2 response.

The Journal of biological chemistry

Wu X,Gowda NM,Kawasawa YI,Gowda DC

Fri Jul 06 00:00:00 EDT 2018

Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties.

Scientific reports

Leroux LP,Nasr M,Valanparambil R,Tam M,Rosa BA,Siciliani E,Hill DE,Zarlenga DS,Jaramillo M,Weinstock JV,Geary TG,Stevenson MM,Urban JF,Mitreva M,Jardim A

Mon Oct 29 00:00:00 EDT 2018

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.

Nature communications

Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR

Thu Aug 30 00:00:00 EDT 2018

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy.

Nature communications

Wang YC,Wu YS,Hung CY,Wang SA,Young MJ,Hsu TI,Hung JJ

Fri Sep 28 00:00:00 EDT 2018

Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases.

Scientific reports

Chang LL,Hsu WH,Kao MC,Chou CC,Lin CC,Liu CJ,Weng BC,Kuo FC,Kuo CH,Lin MH,Wang CJ,Lin CH,Wu DC,Huang SK

Wed Feb 28 00:00:00 EST 2018

Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy.

Scientific reports

Shinde P,Fernandes S,Melinkeri S,Kale V,Limaye L

Mon Apr 09 00:00:00 EDT 2018

Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments.

Nature communications

Yoshitomi H,Kobayashi S,Miyagawa-Hayashino A,Okahata A,Doi K,Nishitani K,Murata K,Ito H,Tsuruyama T,Haga H,Matsuda S,Toguchida J

Wed Sep 19 00:00:00 EDT 2018

The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration.

Cell death & disease

Dollt C,Michel J,Kloss L,Melchers S,Schledzewski K,Becker K,Sauer A,Krewer A,Koll F,Schmieder A

Wed Sep 19 00:00:00 EDT 2018

C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.

Nature communications

Dufour A,Bellac CL,Eckhard U,Solis N,Klein T,Kappelhoff R,Fortelny N,Jobin P,Rozmus J,Mark J,Pavlidis P,Dive V,Barbour SJ,Overall CM

Wed Jun 20 00:00:00 EDT 2018

The oligosaccharides 6'-sialyllactose, 2'-fucosyllactose or galactooligosaccharides do not directly modulate human dendritic cell differentiation or maturation.

PloS one

Perdijk O,van Neerven RJJ,van den Brink E,Savelkoul HFJ,Brugman S

200-04 was used in Cell Culture to study the effect of human milk oligosaccharides (HMOs) 6'-sialyllactose (6'SL) and 2'-fucosyllactose (2'FL) as well as prebiotic galactooligosaccharides (GOS) on dendritic cell (DC) differentiation and maturation to study how HMOs contribute to immune homeostasis and protection against disease.

Tue Jan 22 00:00:00 EST 2019

Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages.

EBioMedicine

Rhys HI,Dell'Accio F,Pitzalis C,Moore A,Norling LV,Perretti M

200-04 was used in In vitro experiments to present new mechanistic evidence underpinning the anti-inflammatory and anti-arthritic properties of neutrophil microvesicles.

Thu Mar 01 00:00:00 EST 2018

A novel probe to assess cytosolic entry of exogenous proteins.

Nature communications

Lu Q,Grotzke JE,Cresswell P

Mon Aug 06 00:00:00 EDT 2018

Integrin CD11b activation drives anti-tumor innate immunity.

Nature communications

Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA

Wed Dec 19 00:00:00 EST 2018

Integrin CD11b activation drives anti-tumor innate immunity.

Nature communications

Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA

Wed Dec 19 00:00:00 EST 2018

IL-1β- and IL-4-polarized macrophages have opposite effects on adipogenesis of intramuscular fibro-adipogenic progenitors in humans.

Scientific reports

Moratal C,Raffort J,Arrighi N,Rekima S,Schaub S,Dechesne CA,Chinetti G,Dani C

Mon Nov 19 00:00:00 EST 2018

A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome.

Cell reports

Su S,Guntur AR,Nguyen DC,Fakory SS,Doucette CC,Leech C,Lotana H,Kelley M,Kohli J,Martino J,Sims-Lucas S,Liaw L,Vary C,Rosen CJ,Brown AC

200-04 was used in In vitro experiments to develop a robust method to generate a renewable source of human beige adipocytes from induced pluripotent stem cells (iPSCs).

Tue Dec 11 00:00:00 EST 2018

Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase.

Frontiers in immunology

Namgaladze D,Zukunft S,Schnütgen F,Kurrle N,Fleming I,Fuhrmann D,Brüne B

200-04 was used in Cell Culture to suggest that ACLY may not be the major regulator of nucleocytoplasmic acetyl-CoA and IL-4-induced polarization in human macrophages.

Fri Oct 25 00:00:00 EDT 2019

M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia.

Cell death & disease

Sheng J,Yang Y,Cui Y,He S,Wang L,Liu L,He Q,Lv T,Han W,Yu W,Hu S,Jin J

Mon Jul 09 00:00:00 EDT 2018

March1-dependent modulation of donor MHC II on CD103⁺ dendritic cells mitigates alloimmunity.

Nature communications

Borges TJ,Murakami N,Machado FD,Murshid A,Lang BJ,Lopes RL,Bellan LM,Uehara M,Antunes KH,Pérez-Saéz MJ,Birrane G,Vianna P,Gonçalves JIB,Zanin RF,Azzi J,Abdi R,Ishido S,Shin JS,Souza APD,Calderwood SK,Riella LV,Bonorino C

Tue Aug 28 00:00:00 EDT 2018

Regulation of IL-22BP in psoriasis.

Scientific reports

Voglis S,Moos S,Kloos L,Wanke F,Zayoud M,Pelczar P,Giannou AD,Pezer S,Albers M,Luessi F,Huber S,Schäkel K,Kurschus FC

Fri Mar 23 00:00:00 EDT 2018

Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential.

Nature communications

Wampach L,Heintz-Buschart A,Fritz JV,Ramiro-Garcia J,Habier J,Herold M,Narayanasamy S,Kaysen A,Hogan AH,Bindl L,Bottu J,Halder R,Sjöqvist C,May P,Andersson AF,de Beaufort C,Wilmes P

Fri Nov 30 00:00:00 EST 2018

Regulatory NLRs Control the RLR-Mediated Type I Interferon and Inflammatory Responses in Human Dendritic Cells.

Frontiers in immunology

Fekete T,Bencze D,Szabo A,Csoma E,Biro T,Bacsi A,Pazmandi K

200-04 was used in Cell Culture to exhibit that NLRX1 is the primary regulator of RLR-mediated innate immune response in human dendritic cells, while NLRC5s only hold a supplemntary role.

Thu Oct 03 00:00:00 EDT 2019

Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.

Nature communications

Lee CC,Lin JC,Hwang WL,Kuo YJ,Chen HK,Tai SK,Lin CC,Yang MH

Fri Sep 14 00:00:00 EDT 2018

A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics.

Journal of immunology (Baltimore, Md. : 1950)

Han K,Nguyen A,Traba J,Yao X,Kaler M,Huffstutler RD,Levine SJ,Sack MN

Sat Sep 01 00:00:00 EDT 2018

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.

Nature

Wartewig T,Kurgyis Z,Keppler S,Pechloff K,Hameister E,Öllinger R,Maresch R,Buch T,Steiger K,Winter C,Rad R,Ruland J

200-04 was used in In vitro experiments to evaluate the role of the receptor, Programmed Death 1, in T cell lymphomagenesis, and the potential implications of this in lymphoma therapy.

Thu Dec 07 00:00:00 EST 2017

High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization.

Immunity

Alcántara-Hernández M,Leylek R,Wagar LE,Engleman EG,Keler T,Marinkovich MP,Davis MM,Nolan GP,Idoyaga J

Tue Dec 19 00:00:00 EST 2017

Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.

Cell metabolism

Thwe PM,Pelgrom LR,Cooper R,Beauchamp S,Reisz JA,D'Alessandro A,Everts B,Amiel E

200-04 was used in In vitro experiments to study the contributions of intracellular glucose stores to glucose sourcing for the support of dendritic cell activation.

Tue Sep 05 00:00:00 EDT 2017

Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia.

Blood

Serafin V,Capuzzo G,Milani G,Minuzzo SA,Pinazza M,Bortolozzi R,Bresolin S,Porcù E,Frasson C,Indraccolo S,Basso G,Accordi B

Thu Dec 21 00:00:00 EST 2017

A noncanonical function of cGAMP in inflammasome priming and activation.

The Journal of experimental medicine

Swanson KV,Junkins RD,Kurkjian CJ,Holley-Guthrie E,Pendse AA,El Morabiti R,Petrucelli A,Barber GN,Benedict CA,Ting JP

Mon Dec 04 00:00:00 EST 2017

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

Nature chemical biology

Johannessen L,Sundberg TB,O'Connell DJ,Kolde R,Berstler J,Billings KJ,Khor B,Seashore-Ludlow B,Fassl A,Russell CN,Latorre IJ,Jiang B,Graham DB,Perez JR,Sicinski P,Phillips AJ,Schreiber SL,Gray NS,Shamji AF,Xavier RJ

200-04 was used in Cell Culture to identify a function for CDK8 and CDK19 in regulating innate immune activation and suggest that these kinases may warrant consideration as therapeutic targets for inflammatory disorders.

Sun Oct 01 00:00:00 EDT 2017

Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.

Cell systems

Martins AJ,Narayanan M,Prüstel T,Fixsen B,Park K,Gottschalk RA,Lu Y,Andrews-Pfannkoch C,Lau WW,Wendelsdorf KV,Tsang JS

200-04 was used in In vitro experiments to explore context-dependent noise propagation among genes in human macrophages.

Wed Apr 26 00:00:00 EDT 2017

The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.

Journal of immunology (Baltimore, Md. : 1950)

Gibson A,Faulkner L,Lichtenfels M,Ogese M,Al-Attar Z,Alfirevic A,Esser PR,Martin SF,Pirmohamed M,Park BK,Naisbitt DJ

Tue Aug 15 00:00:00 EDT 2017

Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Salio M,Gasser O,Gonzalez-Lopez C,Martens A,Veerapen N,Gileadi U,Verter JG,Napolitani G,Anderson R,Painter G,Besra GS,Hermans IF,Cerundolo V

Sun Oct 15 00:00:00 EDT 2017

Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models.

Journal of immunology (Baltimore, Md. : 1950)

Liu S,Hasegawa H,Takemasa E,Suzuki Y,Oka K,Kiyoi T,Takeda H,Ogasawara T,Sawasaki T,Yasukawa M,Maeyama K

Fri Sep 01 00:00:00 EDT 2017

Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Bellora F,Dondero A,Corrias MV,Casu B,Regis S,Caliendo F,Moretta A,Cazzola M,Elena C,Vinti L,Locatelli F,Bottino C,Castriconi R

Tue Aug 15 00:00:00 EDT 2017

Alternatively activated macrophages derived from THP-1 cells promote the fibrogenic activities of human dermal fibroblasts.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Zhu Z,Ding J,Ma Z,Iwashina T,Tredget EE

200-04 was used in In vitro experiments to show differentiation of M0 and polarization of M1 and M2 macrophages.

Mon May 01 00:00:00 EDT 2017

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.

The Journal of biological chemistry

Riess M,Fuchs NV,Idica A,Hamdorf M,Flory E,Pedersen IM,König R

Fri Jan 06 00:00:00 EST 2017

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages.

Scientific reports

Pujantell M,Riveira-Muñoz E,Badia R,Castellví M,Garcia-Vidal E,Sirera G,Puig T,Ramirez C,Clotet B,Esté JA,Ballana E

Tue Oct 17 00:00:00 EDT 2017

Human galectin-9 on the porcine cells affects the cytotoxic activity of M1-differentiated THP-1 cells through inducing a shift in M2-differentiated THP-1 cells.

Xenotransplantation

Jung SH,Hwang JH,Kim SE,Kim YK,Park HC,Lee HT

200-04 was used in Western Blotting to suggest that hGal-9 has a reduction in M1-differentiated THP-1 cell cytotoxic activity-related acute immune rejection in pig-to-human xenotransplantation in addition to its role in lymphoid lineage immune cell regulation.

Sat Jul 01 00:00:00 EDT 2017

Butyrate and propionate inhibit antigen-specific CD8⁺ T cell activation by suppressing IL-12 production by antigen-presenting cells.

Scientific reports

Nastasi C,Fredholm S,Willerslev-Olsen A,Hansen M,Bonefeld CM,Geisler C,Andersen MH,Ødum N,Woetmann A

Mon Nov 06 00:00:00 EST 2017

Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.

Nature communications

Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A

200-04 was used in Cell Culture to identify Foxo1 as a major transcription factor controlling the development of Th9 cells and other IL-9-producing T cells.

Mon Oct 09 00:00:00 EDT 2017

Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.

Nature communications

Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A

200-04 was used in Cell Culture to identify Foxo1 as a major transcription factor controlling the development of Th9 cells and other IL-9-producing T cells.

Mon Oct 09 00:00:00 EDT 2017

IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration.

Scientific reports

Ovsiy I,Riabov V,Manousaridis I,Michel J,Moganti K,Yin S,Liu T,Sticht C,Kremmer E,Harmsen MC,Goerdt S,Gratchev A,Kzhyshkowska J

Mon Dec 04 00:00:00 EST 2017

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.

Nature communications

Veglia F,Tyurin VA,Mohammadyani D,Blasi M,Duperret EK,Donthireddy L,Hashimoto A,Kapralov A,Amoscato A,Angelini R,Patel S,Alicea-Torres K,Weiner D,Murphy ME,Klein-Seetharaman J,Celis E,Kagan VE,Gabrilovich DI

Thu Dec 14 00:00:00 EST 2017

Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs.

Scientific reports

Enomoto Y,Takagi R,Naito Y,Kiniwa T,Tanaka Y,Hamada-Tsutsumi S,Kawano M,Matsushita S,Ochiya T,Miyajima A

Thu Aug 10 00:00:00 EDT 2017

Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors.

Scientific reports

Nie Y,Yang D,Trivett A,Han Z,Xin H,Chen X,Oppenheim JJ

Fri Oct 27 00:00:00 EDT 2017

Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells.

Scientific reports

Strasser L,Dang HH,Schwarz H,Asam C,Ferreira F,Horejs-Hoeck J,Huber CG

Thu Nov 30 00:00:00 EST 2017

Epistatic interactions between mutations of TACI (TNFRSF13B) and TCF3 result in a severe primary immunodeficiency disorder and systemic lupus erythematosus.

Clinical & translational immunology

Ameratunga R,Koopmans W,Woon ST,Leung E,Lehnert K,Slade CA,Tempany JC,Enders A,Steele R,Browett P,Hodgkin PD,Bryant VL

Sun Oct 01 00:00:00 EDT 2017

Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ.

Scientific reports

Holdsworth G,Bon H,Bergin M,Qureshi O,Paveley R,Atkinson J,Huang L,Tewari R,Twomey B,Johnson T

Wed Aug 30 00:00:00 EDT 2017

Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ.

Scientific reports

Holdsworth G,Bon H,Bergin M,Qureshi O,Paveley R,Atkinson J,Huang L,Tewari R,Twomey B,Johnson T

Wed Aug 30 00:00:00 EDT 2017

Local and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils.

Scientific reports

Alvarez KLF,Beldi M,Sarmanho F,Rossetti RAM,Silveira CRF,Mota GR,Andreoli MA,Caruso EDC,Kamillos MF,Souza AM,Mastrocalla H,Clavijo-Salomon MA,Barbuto JAM,Lorenzi NP,Longatto-Filho A,Baracat E,Lopez RVM,Villa LL,Tacla M,Lepique AP

Mon Aug 21 00:00:00 EDT 2017

Sensing and responding to allergic response cytokines through a genetically encoded circuit.

Nature communications

Chassin H,Geering B,Schukur L,Ausländer D,Lang B,Fussenegger M

Tue Oct 24 00:00:00 EDT 2017

Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.

The Journal of biological chemistry

Buzza MS,Johnson TA,Conway GD,Martin EW,Mukhopadhyay S,Shea-Donohue T,Antalis TM

Fri Jun 30 00:00:00 EDT 2017

Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation.

Nature communications

Infantino S,Light A,O'Donnell K,Bryant V,Avery DT,Elliott M,Tangye SG,Belz G,Mackay F,Richard S,Tarlinton D

Thu Oct 12 00:00:00 EDT 2017

Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity.

The Journal of biological chemistry

Takano T,Motozono C,Imai T,Sonoda KH,Nakanishi Y,Yamasaki S

Fri Oct 13 00:00:00 EDT 2017

IL-4 rescues surface IgM expression in chronic lymphocytic leukemia.

Blood

Guo B,Zhang L,Chiorazzi N,Rothstein TL

Thu Jul 28 00:00:00 EDT 2016

Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.

The Journal of clinical investigation

Cantaert T,Schickel JN,Bannock JM,Ng YS,Massad C,Delmotte FR,Yamakawa N,Glauzy S,Chamberlain N,Kinnunen T,Menard L,Lavoie A,Walter JE,Notarangelo LD,Bruneau J,Al-Herz W,Kilic SS,Ochs HD,Cunningham-Rundles C,van der Burg M,Kuijpers TW,Kracker S,Kaneko H,Sekinaka Y,Nonoyama S,Durandy A,Meffre E

Tue Nov 01 00:00:00 EDT 2016

Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury.

Proceedings of the National Academy of Sciences of the United States of America

Rantakari P,Patten DA,Valtonen J,Karikoski M,Gerke H,Dawes H,Laurila J,Ohlmeier S,Elima K,Hübscher SG,Weston CJ,Jalkanen S,Adams DH,Salmi M,Shetty S

Tue Aug 16 00:00:00 EDT 2016

Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.

Proceedings of the National Academy of Sciences of the United States of America

DeKosky BJ,Lungu OI,Park D,Johnson EL,Charab W,Chrysostomou C,Kuroda D,Ellington AD,Ippolito GC,Gray JJ,Georgiou G

Tue May 10 00:00:00 EDT 2016

Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.

Proceedings of the National Academy of Sciences of the United States of America

Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC

Tue Aug 16 00:00:00 EDT 2016

Sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells.

Experimental & molecular medicine

Hong CY,Lee HJ,Choi NR,Jung SH,Vo MC,Hoang MD,Kim HJ,Lee JJ

Fri Aug 19 00:00:00 EDT 2016

Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus.

European journal of immunology

Pichulik T,Khatamzas E,Liu X,Brain O,Delmiro Garcia M,Leslie A,Danis B,Mayer A,Baban D,Ragoussis J,Weber AN,Simmons A

Fri Jan 01 00:00:00 EST 2016

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation.

Oncogenesis

Cheng JT,Deng YN,Yi HM,Wang GY,Fu BS,Chen WJ,Liu W,Tai Y,Peng YW,Zhang Q

Mon Feb 22 00:00:00 EST 2016

Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1.

Stem cells (Dayton, Ohio)

Barcellos-de-Souza P,Comito G,Pons-Segura C,Taddei ML,Gori V,Becherucci V,Bambi F,Margheri F,Laurenzana A,Del Rosso M,Chiarugi P

Sat Oct 01 00:00:00 EDT 2016

Mesenchymal Stromal Cells Induce Peculiar Alternatively Activated Macrophages Capable of Dampening Both Innate and Adaptive Immune Responses.

Stem cells (Dayton, Ohio)

Chiossone L,Conte R,Spaggiari GM,Serra M,Romei C,Bellora F,Becchetti F,Andaloro A,Moretta L,Bottino C

Fri Jul 01 00:00:00 EDT 2016

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

Journal of immunology (Baltimore, Md. : 1950)

Llibre A,López-Macías C,Marafioti T,Mehta H,Partridge A,Kanzig C,Rivellese F,Galson JD,Walker LJ,Milne P,Phillips RE,Kelly DF,Freeman GJ,El Shikh ME,Klenerman P,Willberg CB

Tue Mar 01 00:00:00 EST 2016

Diverse HLA-I Peptide Repertoires of the APC Lines MUTZ3-Derived Immature and Mature Dendritic Cells and THP1-Derived Macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Nyambura LW,Jarmalavicius S,Baleeiro RB,Walden P

Thu Sep 15 00:00:00 EDT 2016

MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c.

Journal of immunology (Baltimore, Md. : 1950)

Wen Q,Zhou C,Xiong W,Su J,He J,Zhang S,Du X,Liu S,Wang J,Ma L

Fri Jul 15 00:00:00 EDT 2016

Efficient Culture of Human Naive and Memory B Cells for Use as APCs.

Journal of immunology (Baltimore, Md. : 1950)

Su KY,Watanabe A,Yeh CH,Kelsoe G,Kuraoka M

Tue Nov 15 00:00:00 EST 2016

Fc Receptor-like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue-like Memory B Cells.

Journal of immunology (Baltimore, Md. : 1950)

Li H,Borrego F,Nagata S,Tolnay M

Sun May 15 00:00:00 EDT 2016

The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.

Journal of immunology (Baltimore, Md. : 1950)

Tosh KW,Mittereder L,Bonne-Annee S,Hieny S,Nutman TB,Singer SM,Sher A,Jankovic D

Fri Jan 01 00:00:00 EST 2016

Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.

Journal of immunology (Baltimore, Md. : 1950)

Peyrassol X,Laeremans T,Gouwy M,Lahura V,Debulpaep M,Van Damme J,Steyaert J,Parmentier M,Langer I

Tue Mar 15 00:00:00 EDT 2016

Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.

Journal of immunology (Baltimore, Md. : 1950)

Pazdrak K,Straub C,Maroto R,Stafford S,White WI,Calhoun WJ,Kurosky A

Tue Nov 15 00:00:00 EST 2016

Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Galaine J,Kellermann G,Guillaume Y,Boidot R,Picard E,Loyon R,Queiroz L,Boullerot L,Beziaud L,Jary M,Mansi L,André C,Lethier L,Ségal-Bendirdjian E,Borg C,Godet Y,Adotévi O

Thu Sep 01 00:00:00 EDT 2016

Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells.

Molecular medicine reports

Shao LN,Zhu BS,Xing CG,Yang XD,Young W,Cao JP

200-04 was used in Sample Preparation (FC/FACS) to study the importance of tumor‚associated macrophages (TAMs) in radiation resistance of colorectal cancer by investigating the effects of autophagy regulation of TAMs on the radiosensitivity of colorectal cancer cells using induced TAM formation from THP‚1 monocyte cells.

Tue Mar 01 00:00:00 EST 2016

Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation.

Scientific reports

Liu L,Sun Q,Bao R,Roth M,Zhong B,Lan X,Tian J,He Q,Li D,Sun J,Yang X,Lu S

Thu Feb 25 00:00:00 EST 2016

MiR-142-3p is a RANKL-dependent inducer of cell death in osteoclasts.

Scientific reports

Fordham JB,Guilfoyle K,Naqvi AR,Nares S

Tue Apr 26 00:00:00 EDT 2016

Ikaros Is a Negative Regulator of B1 Cell Development and Function.

The Journal of biological chemistry

Macias-Garcia A,Heizmann B,Sellars M,Marchal P,Dali H,Pasquali JL,Muller S,Kastner P,Chan S

Fri Apr 22 00:00:00 EDT 2016

Subgroup J avian leukosis virus infection of chicken dendritic cells induces apoptosis via the aberrant expression of microRNAs.

Scientific reports

Liu D,Dai M,Zhang X,Cao W,Liao M

Mon Feb 01 00:00:00 EST 2016

Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.

Nature communications

Serr I,Fürst RW,Achenbach P,Scherm MG,Gökmen F,Haupt F,Sedlmeier EM,Knopff A,Shultz L,Willis RA,Ziegler AG,Daniel C

Tue Mar 15 00:00:00 EDT 2016

Sorting nexin 10 acting as a novel regulator of macrophage polarization mediates inflammatory response in experimental mouse colitis.

Scientific reports

You Y,Zhou C,Li D,Cao ZL,Shen W,Li WZ,Zhang S,Hu B,Shen X

Tue Feb 09 00:00:00 EST 2016

miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer.

Scientific reports

Wang Z,Xu L,Hu Y,Huang Y,Zhang Y,Zheng X,Wang S,Wang Y,Yu Y,Zhang M,Yuan K,Min W

Mon May 09 00:00:00 EDT 2016

Bioelectric modulation of macrophage polarization.

Scientific reports

Li C,Levin M,Kaplan DL

Fri Feb 12 00:00:00 EST 2016

Identification of Differentially Expressed Long Non-coding RNAs in Polarized Macrophages.

Scientific reports

Huang Z,Luo Q,Yao F,Qing C,Ye J,Deng Y,Li J

Fri Jan 22 00:00:00 EST 2016

Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases.

The Journal of biological chemistry

Song X,Ding Y,Liu G,Yang X,Zhao R,Zhang Y,Zhao X,Anderson GJ,Nie G

Fri Apr 15 00:00:00 EDT 2016

Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure.

Scientific reports

Hogan LE,Jones DC,Allen RL

Wed Feb 24 00:00:00 EST 2016

miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells.

Scientific reports

Naqvi AR,Fordham JB,Ganesh B,Nares S

Fri Sep 09 00:00:00 EDT 2016

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.

Nature communications

Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM

Mon Nov 21 00:00:00 EST 2016

CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.

Scientific reports

Su S,Hu B,Shao J,Shen B,Du J,Du Y,Zhou J,Yu L,Zhang L,Chen F,Sha H,Cheng L,Meng F,Zou Z,Huang X,Liu B

Thu Jan 28 00:00:00 EST 2016

Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype.

Scientific reports

Harfuddin Z,Dharmadhikari B,Wong SC,Duan K,Poidinger M,Kwajah S,Schwarz H

Tue Jul 19 00:00:00 EDT 2016

Immunomodulation of Lactobacillus rhamnosus GG (LGG)-derived soluble factors on antigen-presenting cells of healthy blood donors.

Scientific reports

Fong FLY,Kirjavainen PV,El-Nezami H

Thu Mar 10 00:00:00 EST 2016

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.

Nature communications

Canton J,Schlam D,Breuer C,Gütschow M,Glogauer M,Grinstein S

Wed Apr 06 00:00:00 EDT 2016

STAT6 deficiency ameliorates Graves' disease severity by suppressing thyroid epithelial cell hyperplasia.

Cell death & disease

Jiang X,Zha B,Liu X,Liu R,Liu J,Huang E,Qian T,Liu J,Wang Z,Zhang D,Wang L,Chu Y

Thu Dec 01 00:00:00 EST 2016

PGE₂ is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.

Scientific reports

Fujii S,Suzuki K,Kawamoto A,Ishibashi F,Nakata T,Murano T,Ito G,Shimizu H,Mizutani T,Oshima S,Tsuchiya K,Nakamura T,Araki A,Ohtsuka K,Okamoto R,Watanabe M

Wed Nov 09 00:00:00 EST 2016

Secukinumab, a novel anti-IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity.

mAbs

Karle A,Spindeldreher S,Kolbinger F

200-04 was used in Cell Culture to evaluate its immunogenicity potential by applying 2 different in vitro assays: T-cell activation and major histocompatibility complex-associated peptide proteomics (MAPPs).

Tue Dec 13 00:00:00 EST 2016

MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.

Nature medicine

Tada T,Zhang Y,Koyama T,Tobiume M,Tsunetsugu-Yokota Y,Yamaoka S,Fujita H,Tokunaga K

Tue Dec 01 00:00:00 EST 2015

Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.

Nature

Carmi Y,Spitzer MH,Linde IL,Burt BM,Prestwood TR,Perlman N,Davidson MG,Kenkel JA,Segal E,Pusapati GV,Bhattacharya N,Engleman EG

Thu May 07 00:00:00 EDT 2015

A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes.

Nucleic acids research

Zhong F,Zhou N,Wu K,Guo Y,Tan W,Zhang H,Zhang X,Geng G,Pan T,Luo H,Zhang Y,Xu Z,Liu J,Liu B,Gao W,Liu C,Ren L,Li J,Zhou J,Zhang H

200-04 was used in Sample Preparation (Western Blotting) to demonstrate a novel piRNA mechanism in regulating gene expression in highly differentiated somatic cells.

Wed Dec 02 00:00:00 EST 2015

Bee venom processes human skin lipids for presentation by CD1a.

The Journal of experimental medicine

Bourgeois EA,Subramaniam S,Cheng TY,De Jong A,Layre E,Ly D,Salimi M,Legaspi A,Modlin RL,Salio M,Cerundolo V,Moody DB,Ogg G

Mon Feb 09 00:00:00 EST 2015

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow.

The Journal of experimental medicine

Lee J,Breton G,Oliveira TY,Zhou YJ,Aljoufi A,Puhr S,Cameron MJ,Sékaly RP,Nussenzweig MC,Liu K

Mon Mar 09 00:00:00 EDT 2015

Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response.

Proceedings of the National Academy of Sciences of the United States of America

Chen JT,Chen CH,Ku KL,Hsiao M,Chiang CP,Hsu TL,Chen MH,Wong CH

Tue Oct 20 00:00:00 EDT 2015

Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.

Aging cell

van der Geest KS,Abdulahad WH,Teteloshvili N,Tete SM,Peters JH,Horst G,Lorencetti PG,Bos NA,Lambeck A,Roozendaal C,Kroesen BJ,Koenen HJ,Joosten I,Brouwer E,Boots AM

Thu Oct 01 00:00:00 EDT 2015

Cross-reactivity of hepatitis C virus specific vaccine-induced T cells at immunodominant epitopes.

European journal of immunology

Kelly C,Swadling L,Brown A,Capone S,Folgori A,Salio M,Klenerman P,Barnes E

Thu Jan 01 00:00:00 EST 2015

Human monocyte-derived dendritic cells turn into foamy dendritic cells with IL-17A.

Journal of lipid research

Salvatore G,Bernoud-Hubac N,Bissay N,Debard C,Daira P,Meugnier E,Proamer F,Hanau D,Vidal H,Aricò M,Delprat C,Mahtouk K

Mon Jun 01 00:00:00 EDT 2015

A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Hou TZ,Qureshi OS,Wang CJ,Baker J,Young SP,Walker LS,Sansom DM

Sun Mar 01 00:00:00 EST 2015

Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation.

Journal of immunology (Baltimore, Md. : 1950)

Toniolo PA,Liu S,Yeh JE,Moraes-Vieira PM,Walker SR,Vafaizadeh V,Barbuto JA,Frank DA

Wed Apr 01 00:00:00 EDT 2015

IL-7 Abrogates the Immunosuppressive Function of Human Double-Negative T Cells by Activating Akt/mTOR Signaling.

Journal of immunology (Baltimore, Md. : 1950)

Allgäuer A,Schreiner E,Ferrazzi F,Ekici AB,Gerbitz A,Mackensen A,Völkl S

Thu Oct 01 00:00:00 EDT 2015

Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.

Journal of immunology (Baltimore, Md. : 1950)

Rossetti M,Spreafico R,Saidin S,Chua C,Moshref M,Leong JY,Tan YK,Thumboo J,van Loosdregt J,Albani S

Thu Jan 01 00:00:00 EST 2015

Genetic vaccines to potentiate the effective CD103+ dendritic cell-mediated cross-priming of antitumor immunity.

Journal of immunology (Baltimore, Md. : 1950)

Zhang Y,Chen G,Liu Z,Tian S,Zhang J,Carey CD,Murphy KM,Storkus WJ,Falo LD,You Z

Mon Jun 15 00:00:00 EDT 2015

Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.

Journal of immunology (Baltimore, Md. : 1950)

Mattiola I,Pesant M,Tentorio PF,Molgora M,Marcenaro E,Lugli E,Locati M,Mavilio D

Tue Sep 15 00:00:00 EDT 2015

Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation.

Journal of immunology (Baltimore, Md. : 1950)

Baharom F,Thomas S,Bieder A,Hellmér M,Volz J,Sandgren KJ,McInerney GM,Karlsson Hedestam GB,Mellman I,Smed-Sörensen A

Fri May 01 00:00:00 EDT 2015

TGF-β1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes.

Journal of immunology (Baltimore, Md. : 1950)

Nurgazieva D,Mickley A,Moganti K,Ming W,Ovsyi I,Popova A,Awad K,Wang N,Bieback K,Goerdt S,Kzhyshkowska J,Gratchev A

Thu Jan 15 00:00:00 EST 2015

TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses.

Journal of immunology (Baltimore, Md. : 1950)

Riise RE,Bernson E,Aurelius J,Martner A,Pesce S,Della Chiesa M,Marcenaro E,Bylund J,Hellstrand K,Moretta L,Moretta A,Thorén FB

Sat Aug 01 00:00:00 EDT 2015

Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9.

Journal of immunology (Baltimore, Md. : 1950)

Lai CY,Yeh DW,Lu CH,Liu YL,Huang LR,Kao CY,Chen HY,Huang CY,Chang CH,Luo Y,Xiang R,Chuang TH

Thu Oct 15 00:00:00 EDT 2015

Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity.

Journal of immunology (Baltimore, Md. : 1950)

Baruzzi A,Remelli S,Lorenzetto E,Sega M,Chignola R,Berton G

Sun Nov 15 00:00:00 EST 2015

The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.

Journal of immunology (Baltimore, Md. : 1950)

Pundir P,MacDonald CA,Kulka M

Tue Sep 15 00:00:00 EDT 2015

miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells.

Journal of immunology (Baltimore, Md. : 1950)

Naqvi AR,Fordham JB,Nares S

Sun Feb 15 00:00:00 EST 2015

Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-γ by a T-bet-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

Bürgler S,Gimeno A,Parente-Ribes A,Wang D,Os A,Devereux S,Jebsen P,Bogen B,Tjønnfjord GE,Munthe LA

Thu Jan 15 00:00:00 EST 2015

Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Takami M,Fujimaki K,Nishimura MI,Iwashima M

Tue Sep 15 00:00:00 EDT 2015

IL-4 Downregulates IL-1β and IL-6 and Induces GATA3 in Psoriatic Epidermal Cells: Route of Action of a Th2 Cytokine.

Journal of immunology (Baltimore, Md. : 1950)

Onderdijk AJ,Baerveldt EM,Kurek D,Kant M,Florencia EF,Debets R,Prens EP

Sat Aug 15 00:00:00 EDT 2015

Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin.

Proteins

Obmolova G,Teplyakov A,Malia TJ,Keough E,Luo J,Sweet R,Jacobs SA,Yi F,Hippensteel R,O'Neil KT,Gilliland GL

Mon Jun 01 00:00:00 EDT 2015

Batf is important for IL-4 expression in T follicular helper cells.

Nature communications

Sahoo A,Alekseev A,Tanaka K,Obertas L,Lerman B,Haymaker C,Clise-Dwyer K,McMurray JS,Nurieva R

Mon Aug 17 00:00:00 EDT 2015

IL-10 induces the development of immunosuppressive CD14(+)HLA-DR(low/-) monocytes in B-cell non-Hodgkin lymphoma.

Blood cancer journal

Xiu B,Lin Y,Grote DM,Ziesmer SC,Gustafson MP,Maas ML,Zhang Z,Dietz AB,Porrata LF,Novak AJ,Liang AB,Yang ZZ,Ansell SM

Fri Jul 31 00:00:00 EDT 2015

Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclasts.

The Journal of biological chemistry

Oh J,Kim JY,Kim HS,Oh JC,Cheon YH,Park J,Yoon KH,Lee MS,Youn BS

Fri Jan 23 00:00:00 EST 2015

MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins.

The Journal of biological chemistry

Park H,Huang X,Lu C,Cairo MS,Zhou X

Fri Jan 30 00:00:00 EST 2015

Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease.

Scientific reports

Becker M,De Bastiani MA,Parisi MM,Guma FT,Markoski MM,Castro MA,Kaplan MH,Barbé-Tuana FM,Klamt F

Tue Aug 25 00:00:00 EDT 2015

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.

Nature communications

Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E

Mon Oct 05 00:00:00 EDT 2015

PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy.

Cell death & disease

Wang SC,Li YH,Piao HL,Hong XW,Zhang D,Xu YY,Tao Y,Wang Y,Yuan MM,Li DJ,Du MR

Thu May 07 00:00:00 EDT 2015

The effect of short-chain fatty acids on human monocyte-derived dendritic cells.

Scientific reports

Nastasi C,Candela M,Bonefeld CM,Geisler C,Hansen M,Krejsgaard T,Biagi E,Andersen MH,Brigidi P,Ødum N,Litman T,Woetmann A

Fri Nov 06 00:00:00 EST 2015

High affinity targeting of CD23 inhibits IgE synthesis in human B cells.

Immunity, inflammation and disease

Fellmann M,Buschor P,Röthlisberger S,Zellweger F,Vogel M

Tue Dec 01 00:00:00 EST 2015

Mica Nanoparticle, STB-HO Eliminates the Human Breast Carcinoma Cells by Regulating the Interaction of Tumor with its Immune Microenvironment.

Scientific reports

Kang TW,Kim HS,Lee BC,Shin TH,Choi SW,Kim YJ,Lee HY,Jung YK,Seo KW,Kang KS

Thu Dec 03 00:00:00 EST 2015

Slit2N Inhibits Transmission of HIV-1 from Dendritic Cells to T-cells by Modulating Novel Cytoskeletal Elements.

Scientific reports

Shrivastava A,Prasad A,Kuzontkoski PM,Yu J,Groopman JE

Thu Nov 19 00:00:00 EST 2015

Galectin-1 regulates tissue exit of specific dendritic cell populations.

The Journal of biological chemistry

Thiemann S,Man JH,Chang MH,Lee B,Baum LG

Fri Sep 11 00:00:00 EDT 2015

Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry.

The Journal of experimental medicine

Williams GR,Fierens K,Preston SG,Lunn D,Rysnik O,De Prijck S,Kool M,Buckley HC,Lambrecht BN,O'Hare D,Austyn JM

Mon Jun 02 00:00:00 EDT 2014

A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.

Arthritis & rheumatology (Hoboken, N.J.)

Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L

Fri Aug 01 00:00:00 EDT 2014

Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication.

Proceedings of the National Academy of Sciences of the United States of America

Guo Z,Tilburgs T,Wong B,Strominger JL

Tue Sep 30 00:00:00 EDT 2014

Adaptive immune contexture at the tumour site and downmodulation of circulating myeloid-derived suppressor cells in the response of solitary fibrous tumour patients to anti-angiogenic therapy.

British journal of cancer

Tazzari M,Negri T,Rini F,Vergani B,Huber V,Villa A,Dagrada P,Colombo C,Fiore M,Gronchi A,Stacchiotti S,Casali PG,Pilotti S,Rivoltini L,Castelli C

Tue Sep 23 00:00:00 EDT 2014

Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells.

Immunology and cell biology

Ghamlouch H,Ouled-Haddou H,Guyart A,Regnier A,Trudel S,Claisse JF,Fuentes V,Royer B,Marolleau JP,Gubler B

Fri Aug 01 00:00:00 EDT 2014

Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus.

Journal of immunology (Baltimore, Md. : 1950)

Kato H,Perl A

Thu May 01 00:00:00 EDT 2014

Human dendritic cells exhibit a pronounced type I IFN signature following Leishmania major infection that is required for IL-12 induction.

Journal of immunology (Baltimore, Md. : 1950)

Favila MA,Geraci NS,Zeng E,Harker B,Condon D,Cotton RN,Jayakumar A,Tripathi V,McDowell MA

Sun Jun 15 00:00:00 EDT 2014

Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1.

Journal of immunology (Baltimore, Md. : 1950)

Madan-Lala R,Sia JK,King R,Adekambi T,Monin L,Khader SA,Pulendran B,Rengarajan J

Thu May 01 00:00:00 EDT 2014

Eosinophils regulate peripheral B cell numbers in both mice and humans.

Journal of immunology (Baltimore, Md. : 1950)

Wong TW,Doyle AD,Lee JJ,Jelinek DF

Tue Apr 15 00:00:00 EDT 2014

Activin A as a mediator of NK-dendritic cell functional interactions.

Journal of immunology (Baltimore, Md. : 1950)

Seeger P,Bosisio D,Parolini S,Badolato R,Gismondi A,Santoni A,Sozzani S

Sat Feb 01 00:00:00 EST 2014

Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity.

Journal of immunology (Baltimore, Md. : 1950)

Herter S,Birk MC,Klein C,Gerdes C,Umana P,Bacac M

Sat Mar 01 00:00:00 EST 2014

IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type I IFN.

Journal of immunology (Baltimore, Md. : 1950)

Cao Y,Zhang R,Zhang W,Zhu C,Yu Y,Song Y,Wang Q,Bai L,Liu Y,Wu K,Wu J

Wed Jan 15 00:00:00 EST 2014

RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.

Journal of immunology (Baltimore, Md. : 1950)

Colak E,Leslie A,Zausmer K,Khatamzas E,Kubarenko AV,Pichulik T,Klimosch SN,Mayer A,Siggs O,Hector A,Fischer R,Klesser B,Rautanen A,Frank M,Hill AV,Manoury B,Beutler B,Hartl D,Simmons A,Weber AN

Sun Jun 15 00:00:00 EDT 2014

Chronic exposure to glucocorticoids shapes gene expression and modulates innate and adaptive activation pathways in macrophages with distinct changes in leukocyte attraction.

Journal of immunology (Baltimore, Md. : 1950)

van de Garde MD,Martinez FO,Melgert BN,Hylkema MN,Jonkers RE,Hamann J

Sat Feb 01 00:00:00 EST 2014

Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way.

Journal of immunology (Baltimore, Md. : 1950)

Maier E,Werner D,Duschl A,Bohle B,Horejs-Hoeck J

Tue Jul 15 00:00:00 EDT 2014

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Balan S,Ollion V,Colletti N,Chelbi R,Montanana-Sanchis F,Liu H,Vu Manh TP,Sanchez C,Savoret J,Perrot I,Doffin AC,Fossum E,Bechlian D,Chabannon C,Bogen B,Asselin-Paturel C,Shaw M,Soos T,Caux C,Valladeau-Guilemond J,Dalod M

Fri Aug 15 00:00:00 EDT 2014

Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Kawasaki N,Rillahan CD,Cheng TY,Van Rhijn I,Macauley MS,Moody DB,Paulson JC

Fri Aug 15 00:00:00 EDT 2014

Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival.

Journal of immunology (Baltimore, Md. : 1950)

Kis-Toth K,Tsokos GC

Thu May 01 00:00:00 EDT 2014

Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.

Journal of immunology (Baltimore, Md. : 1950)

Volonté A,Di Tomaso T,Spinelli M,Todaro M,Sanvito F,Albarello L,Bissolati M,Ghirardelli L,Orsenigo E,Ferrone S,Doglioni C,Stassi G,Dellabona P,Staudacher C,Parmiani G,Maccalli C

Wed Jan 01 00:00:00 EST 2014

A new tool to quantify receptor recruitment to cell contact sites during host-pathogen interaction.

PLoS computational biology

Graus MS,Pehlke C,Wester MJ,Davidson LB,Steinberg SL,Neumann AK

200-04 was used in Cell Culture to evaluate the use of 3D multichannel laser scanning confocal microscopy to quantify receptor recruitment between primary human dendritic cells and fungal pathogens.

Thu May 01 00:00:00 EDT 2014

Interaction between pancreatic cancer cells and tumor-associated macrophages promotes the invasion of pancreatic cancer cells and the differentiation and migration of macrophages.

IUBMB life

Meng F,Li C,Li W,Gao Z,Guo K,Song S

200-04 was used in Cell Culture to evaluate the impact of pancreatic cancer cell interaction with macrophages on the differentiation and function of macrophages and the behaviors of pancreatic cancer cells in vitro to show that the interaction between pancreatic cancer cells and tumor-associated macrophages may play a pivotal role in the progression of pancreatic cancer.

Mon Dec 01 00:00:00 EST 2014

Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.

PloS one

Kongsbak M,von Essen MR,Boding L,Levring TB,Schjerling P,Lauritsen JP,Woetmann A,Ødum N,Bonefeld CM,Geisler C

200-04 was used in Cell Culture to determine if and how 1,25(OH)2D3 by itself regulates vitamin D receptor (VDR) expression in human CD4+ T cells.

Thu Jun 04 00:00:00 EDT 2015

Regulation of activation-associated microRNA accumulation rates during monocyte-to-macrophage differentiation.

The Journal of biological chemistry

Eigsti RL,Sudan B,Wilson ME,Graff JW

Fri Oct 10 00:00:00 EDT 2014

Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment.

The Journal of biological chemistry

Shao Z,Morser J,Leung LLK

Fri Sep 26 00:00:00 EDT 2014

Low molecular weight hyaluronan activates cytosolic phospholipase A2α and eicosanoid production in monocytes and macrophages.

The Journal of biological chemistry

Sokolowska M,Chen LY,Eberlein M,Martinez-Anton A,Liu Y,Alsaaty S,Qi HY,Logun C,Horton M,Shelhamer JH

Fri Feb 14 00:00:00 EST 2014

Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33.

The Journal of biological chemistry

Ishida A,Akita K,Mori Y,Tanida S,Toda M,Inoue M,Nakada H

Fri Sep 05 00:00:00 EDT 2014

High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

Scientific reports

Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ

Wed Apr 23 00:00:00 EDT 2014

The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.

Immunity

Brain O,Owens BM,Pichulik T,Allan P,Khatamzas E,Leslie A,Steevels T,Sharma S,Mayer A,Catuneanu AM,Morton V,Sun MY,Jewell D,Coccia M,Harrison O,Maloy K,Schönefeldt S,Bornschein S,Liston A,Simmons A

Thu Sep 19 00:00:00 EDT 2013

Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.

Blood

Wölfl M,Schwinn S,Yoo YE,Reß ML,Braun M,Chopra M,Schreiber SC,Ayala VI,Ohlen C,Eyrich M,Beilhack A,Schlegel PG

Thu Aug 15 00:00:00 EDT 2013

CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia.

Blood

Fedorchenko O,Stiefelhagen M,Peer-Zada AA,Barthel R,Mayer P,Eckei L,Breuer A,Crispatzu G,Rosen N,Landwehr T,Lilienthal N,Möllmann M,Montesinos-Rongen M,Heukamp L,Dürig J,Hallek M,Fingerle-Rowson G,Herling M

Thu May 16 00:00:00 EDT 2013

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.

Blood

Martinez FO,Helming L,Milde R,Varin A,Melgert BN,Draijer C,Thomas B,Fabbri M,Crawshaw A,Ho LP,Ten Hacken NH,Cobos Jiménez V,Kootstra NA,Hamann J,Greaves DR,Locati M,Mantovani A,Gordon S

Thu Feb 28 00:00:00 EST 2013

Regulation of dendritic cell activation by microRNA let-7c and BLIMP1.

The Journal of clinical investigation

Kim SJ,Gregersen PK,Diamond B

Fri Feb 01 00:00:00 EST 2013

Identification of human CCR8 as a CCL18 receptor.

The Journal of experimental medicine

Islam SA,Ling MF,Leung J,Shreffler WG,Luster AD

Mon Sep 23 00:00:00 EDT 2013

MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.

The Journal of experimental medicine

Long HM,Chagoury OL,Leese AM,Ryan GB,James E,Morton LT,Abbott RJ,Sabbah S,Kwok W,Rickinson AB

Mon May 06 00:00:00 EDT 2013

Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression.

Proceedings of the National Academy of Sciences of the United States of America

Yamaguchi T,Kishi A,Osaki M,Morikawa H,Prieto-Martin P,Wing K,Saito T,Sakaguchi S

Tue Jun 04 00:00:00 EDT 2013

Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation.

Proceedings of the National Academy of Sciences of the United States of America

Kawasaki N,Vela JL,Nycholat CM,Rademacher C,Khurana A,van Rooijen N,Crocker PR,Kronenberg M,Paulson JC

Tue May 07 00:00:00 EDT 2013

An upstream open reading frame modulates ebola virus polymerase translation and virus replication.

PLoS pathogens

Shabman RS,Hoenen T,Groseth A,Jabado O,Binning JM,Amarasinghe GK,Feldmann H,Basler CF

Tue Jan 01 00:00:00 EST 2013

The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.

Journal of immunology (Baltimore, Md. : 1950)

Mimura K,Shiraishi K,Mueller A,Izawa S,Kua LF,So J,Yong WP,Fujii H,Seliger B,Kiessling R,Kono K

Sun Dec 15 00:00:00 EST 2013

Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines.

Journal of immunology (Baltimore, Md. : 1950)

Chen HW,Chen HY,Wang LT,Wang FH,Fang LW,Lai HY,Chen HH,Lu J,Hung MS,Cheng Y,Chen MY,Liu SJ,Chong P,Lee OK,Hsu SC

Wed May 15 00:00:00 EDT 2013

Adam8 limits the development of allergic airway inflammation in mice.

Journal of immunology (Baltimore, Md. : 1950)

Knolle MD,Nakajima T,Hergrueter A,Gupta K,Polverino F,Craig VJ,Fyfe SE,Zahid M,Permaul P,Cernadas M,Montano G,Tesfaigzi Y,Sholl L,Kobzik L,Israel E,Owen CA

Sat Jun 15 00:00:00 EDT 2013

Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment.

Journal of immunology (Baltimore, Md. : 1950)

Rawal S,Chu F,Zhang M,Park HJ,Nattamai D,Kannan S,Sharma R,Delgado D,Chou T,Lin HY,Baladandayuthapani V,Luong A,Vega F,Fowler N,Dong C,Davis RE,Neelapu SS

Sat Jun 15 00:00:00 EDT 2013

Dendritic cell reprogramming by endogenously produced lactic acid.

Journal of immunology (Baltimore, Md. : 1950)

Nasi A,Fekete T,Krishnamurthy A,Snowden S,Rajnavölgyi E,Catrina AI,Wheelock CE,Vivar N,Rethi B

Sun Sep 15 00:00:00 EDT 2013

IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.

Journal of immunology (Baltimore, Md. : 1950)

Ding BB,Bi E,Chen H,Yu JJ,Ye BH

Fri Feb 15 00:00:00 EST 2013

PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.

Journal of immunology (Baltimore, Md. : 1950)

Chang HH,Miaw SC,Tseng W,Sun YW,Liu CC,Tsao HW,Ho IC

Sun Sep 01 00:00:00 EDT 2013

Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.

Journal of immunology (Baltimore, Md. : 1950)

Sato T,Kitawaki T,Fujita H,Iwata M,Iyoda T,Inaba K,Ohteki T,Hasegawa S,Kawada K,Sakai Y,Ikeuchi H,Nakase H,Niwa A,Takaori-Kondo A,Kadowaki N

Sun Sep 15 00:00:00 EDT 2013

Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.

Journal of immunology (Baltimore, Md. : 1950)

Pauls E,Jimenez E,Ruiz A,Permanyer M,Ballana E,Costa H,Nascimiento R,Parkhouse RM,Peña R,Riveiro-Muñoz E,Martinez MA,Clotet B,Esté JA,Bofill M

Wed May 01 00:00:00 EDT 2013

Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis.

Journal of immunology (Baltimore, Md. : 1950)

Seshadri C,Turner MT,Lewinsohn DM,Moody DB,Van Rhijn I

Tue Jan 01 00:00:00 EST 2013

Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response.

PloS one

Yu Q,Chow EM,McCaw SE,Hu N,Byrd D,Amet T,Hu S,Ostrowski MA,Gray-Owen SD

Thu Aug 08 00:00:00 EDT 2013

Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.

PloS one

Fossati-Jimack L,Ling GS,Cortini A,Szajna M,Malik TH,McDonald JU,Pickering MC,Cook HT,Taylor PR,Botto M

Fri Sep 27 00:00:00 EDT 2013

Immunologic targeting of FOXP3 in inflammatory breast cancer cells.

PloS one

Nair S,Aldrich AJ,McDonnell E,Cheng Q,Aggarwal A,Patel P,Williams MM,Boczkowski D,Lyerly HK,Morse MA,Devi GR

Tue Jul 09 00:00:00 EDT 2013

Chemoresistance of human monocyte-derived dendritic cells is regulated by IL-17A.

PloS one

Olsson Åkefeldt S,Maisse C,Belot A,Mazzorana M,Salvatore G,Bissay N,Jurdic P,Aricò M,Rabourdin-Combe C,Henter JI,Delprat C

Tue Aug 13 00:00:00 EDT 2013

Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.

PloS one

Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T

Fri Sep 06 00:00:00 EDT 2013

The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs.

PloS one

Szabo A,Gogolak P,Pazmandi K,Kis-Toth K,Riedl K,Wizel B,Lingnau K,Bacsi A,Rethi B,Rajnavolgyi E

Mon Dec 02 00:00:00 EST 2013

Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell.

Scientific reports

Kakazu E,Kondo Y,Kogure T,Ninomiya M,Kimura O,Ueno Y,Shimosegawa T

Tue Dec 10 00:00:00 EST 2013

Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function.

The Journal of biological chemistry

So L,Yea SS,Oak JS,Lu M,Manmadhan A,Ke QH,Janes MR,Kessler LV,Kucharski JM,Li LS,Martin MB,Ren P,Jessen KA,Liu Y,Rommel C,Fruman DA

Fri Feb 22 00:00:00 EST 2013

Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro study.

PloS one

Basso D,Fogar P,Falconi M,Fadi E,Sperti C,Frasson C,Greco E,Tamburrino D,Teolato S,Moz S,Bozzato D,Pelloso M,Padoan A,De Franchis G,Gnatta E,Facco M,Zambon CF,Navaglia F,Pasquali C,Basso G,Semenzato G,Pedrazzoli S,Pederzoli P,Plebani M

Fri Sep 06 00:00:00 EDT 2013

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Blood

Ma CS,Avery DT,Chan A,Batten M,Bustamante J,Boisson-Dupuis S,Arkwright PD,Kreins AY,Averbuch D,Engelhard D,Magdorf K,Kilic SS,Minegishi Y,Nonoyama S,French MA,Choo S,Smart JM,Peake J,Wong M,Gray P,Cook MC,Fulcher DA,Casanova JL,Deenick EK,Tangye SG

Thu Apr 26 00:00:00 EDT 2012

Mast cells play a protumorigenic role in primary cutaneous lymphoma.

Blood

Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K

Thu Sep 06 00:00:00 EDT 2012

DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.

Blood

Hosszu KK,Valentino A,Vinayagasundaram U,Vinayagasundaram R,Joyce MG,Ji Y,Peerschke EI,Ghebrehiwet B

Thu Aug 09 00:00:00 EDT 2012

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology.

Blood

Pello OM,De Pizzol M,Mirolo M,Soucek L,Zammataro L,Amabile A,Doni A,Nebuloni M,Swigart LB,Evan GI,Mantovani A,Locati M

Thu Jan 12 00:00:00 EST 2012

Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.

Blood

Hutter C,Kauer M,Simonitsch-Klupp I,Jug G,Schwentner R,Leitner J,Bock P,Steinberger P,Bauer W,Carlesso N,Minkov M,Gadner H,Stingl G,Kovar H,Kriehuber E

Thu Dec 20 00:00:00 EST 2012

Periostin promotes chronic allergic inflammation in response to Th2 cytokines.

The Journal of clinical investigation

Masuoka M,Shiraishi H,Ohta S,Suzuki S,Arima K,Aoki S,Toda S,Inagaki N,Kurihara Y,Hayashida S,Takeuchi S,Koike K,Ono J,Noshiro H,Furue M,Conway SJ,Narisawa Y,Izuhara K

Sun Jul 01 00:00:00 EDT 2012

IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.

The Journal of clinical investigation

Liu D,Song L,Wei J,Courtney AN,Gao X,Marinova E,Guo L,Heczey A,Asgharzadeh S,Kim E,Dotti G,Metelitsa LS

Fri Jun 01 00:00:00 EDT 2012

Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4.

The Journal of experimental medicine

Junker Y,Zeissig S,Kim SJ,Barisani D,Wieser H,Leffler DA,Zevallos V,Libermann TA,Dillon S,Freitag TL,Kelly CP,Schuppan D

Mon Dec 17 00:00:00 EST 2012

Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.

The Journal of experimental medicine

Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H

Mon Oct 22 00:00:00 EDT 2012

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.

The Journal of experimental medicine

Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ

Mon Jan 16 00:00:00 EST 2012

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.

Proceedings of the National Academy of Sciences of the United States of America

Zervantonakis IK,Hughes-Alford SK,Charest JL,Condeelis JS,Gertler FB,Kamm RD

Tue Aug 21 00:00:00 EDT 2012

C1q limits dendritic cell differentiation and activation by engaging LAIR-1.

Proceedings of the National Academy of Sciences of the United States of America

Son M,Santiago-Schwarz F,Al-Abed Y,Diamond B

Tue Nov 13 00:00:00 EST 2012

Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia.

Journal of clinical immunology

Liu Y,Wu Y,Lam KT,Lee PP,Tu W,Lau YL

Fri Jun 01 00:00:00 EDT 2012

Human papillomavirus type 8 interferes with a novel C/EBPβ-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration.

PLoS pathogens

Sperling T,Ołdak M,Walch-Rückheim B,Wickenhauser C,Doorbar J,Pfister H,Malejczyk M,Majewski S,Keates AC,Smola S

Tue Jan 29 00:00:00 EST 2013

DENV inhibits type I IFN production in infected cells by cleaving human STING.

PLoS pathogens

Aguirre S,Maestre AM,Pagni S,Patel JR,Savage T,Gutman D,Maringer K,Bernal-Rubio D,Shabman RS,Simon V,Rodriguez-Madoz JR,Mulder LC,Barber GN,Fernandez-Sesma A

Thu Apr 04 00:00:00 EDT 2013

Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent.

Immunology and cell biology

Hillyer P,Mane VP,Schramm LM,Puig M,Verthelyi D,Chen A,Zhao Z,Navarro MB,Kirschman KD,Bykadi S,Jubin RG,Rabin RL

Sat Sep 01 00:00:00 EDT 2012

Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.

Arthritis research & therapy

Li Y,Zhao LD,Tong LS,Qian SN,Ren Y,Zhang L,Ding X,Chen Y,Wang YX,Zhang W,Zeng XF,Zhang FC,Tang FL,Zhang X,Ba DN,He W,Cao XT,Lipsky PE

Wed May 23 00:00:00 EDT 2012

Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells.

Laboratory investigation; a journal of technical methods and pathology

Tsakiris I,Torocsik D,Gyongyosi A,Dozsa A,Szatmari I,Szanto A,Soos G,Nemes Z,Igali L,Marton I,Takats Z,Nagy L,Dezso B

Thu Mar 01 00:00:00 EST 2012

Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.

Journal of immunology (Baltimore, Md. : 1950)

Jeffery LE,Wood AM,Qureshi OS,Hou TZ,Gardner D,Briggs Z,Kaur S,Raza K,Sansom DM

Sat Dec 01 00:00:00 EST 2012

Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Journal of immunology (Baltimore, Md. : 1950)

Lissauer D,Piper K,Goodyear O,Kilby MD,Moss PA

Sun Jul 15 00:00:00 EDT 2012

Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Meda C,Molla F,De Pizzol M,Regano D,Maione F,Capano S,Locati M,Mantovani A,Latini R,Bussolino F,Giraudo E

Sun Apr 15 00:00:00 EDT 2012

An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Zhang T,Wu MR,Sentman CL

Sat Sep 01 00:00:00 EDT 2012

Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.

Journal of immunology (Baltimore, Md. : 1950)

Kitamura H,Kobayashi M,Wakita D,Nishimura T

Tue May 01 00:00:00 EDT 2012

Cyanovirin-N inhibits mannose-dependent Mycobacterium-C-type lectin interactions but does not protect against murine tuberculosis.

Journal of immunology (Baltimore, Md. : 1950)

Driessen NN,Boshoff HI,Maaskant JJ,Gilissen SA,Vink S,van der Sar AM,Vandenbroucke-Grauls CM,Bewley CA,Appelmelk BJ,Geurtsen J

Mon Oct 01 00:00:00 EDT 2012

Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity.

Journal of immunology (Baltimore, Md. : 1950)

Kaplan A,Ma J,Kyme P,Wolf AJ,Becker CA,Tseng CW,Liu GY,Underhill DM

Thu Nov 01 00:00:00 EDT 2012

Enhancing immunostimulatory function of human embryonic stem cell-derived dendritic cells by CD1d overexpression.

Journal of immunology (Baltimore, Md. : 1950)

Zeng J,Shahbazi M,Wu C,Toh HC,Wang S

Tue May 01 00:00:00 EDT 2012

Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Saada S,Marget P,Fauchais AL,Lise MC,Chemin G,Sindou P,Martel C,Delpy L,Vidal E,Jaccard A,Troutaud D,Lalloué F,Jauberteau MO

Sat Dec 01 00:00:00 EST 2012

Human γδ T lymphocytes are licensed for professional antigen presentation by interaction with opsonized target cells.

Journal of immunology (Baltimore, Md. : 1950)

Himoudi N,Morgenstern DA,Yan M,Vernay B,Saraiva L,Wu Y,Cohen CJ,Gustafsson K,Anderson J

Wed Feb 15 00:00:00 EST 2012

Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.

Journal of immunology (Baltimore, Md. : 1950)

Gallo RM,Khan MA,Shi J,Kapur R,Wei L,Bailey JC,Liu J,Brutkiewicz RR

Wed Aug 15 00:00:00 EDT 2012

Elevated circulating interleukin-27 in patients with coronary artery disease is associated with dendritic cells, oxidized low-density lipoprotein, and severity of coronary artery stenosis.

Mediators of inflammation

Jin W,Zhao Y,Yan W,Cao L,Zhang W,Wang M,Zhang T,Fu Q,Li Z

Wed Nov 28 00:00:00 EST 2012

Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.

Gene therapy

Silk KM,Silk JD,Ichiryu N,Davies TJ,Nolan KF,Leishman AJ,Carpenter L,Watt SM,Cerundolo V,Fairchild PJ

Mon Oct 01 00:00:00 EDT 2012

Gene expression profiling of dendritic cells in different physiological stages under Cordyceps sinensis treatment.

PloS one

Li CY,Chiang CS,Cheng WC,Wang SC,Cheng HT,Chen CR,Shu WY,Tsai ML,Hseu RS,Chang CW,Huang CY,Fang SH,Hsu IC

Fri Dec 07 00:00:00 EST 2012

Both lethal and edema toxins of Bacillus anthracis disrupt the human dendritic cell chemokine network.

PloS one

Cleret-Buhot A,Mathieu J,Tournier JN,Quesnel-Hellmann A

Thu Apr 25 00:00:00 EDT 2013

Slit2N/Robo1 inhibit HIV-gp120-induced migration and podosome formation in immature dendritic cells by sequestering LSP1 and WASp.

PloS one

Prasad A,Kuzontkoski PM,Shrivastava A,Zhu W,Li DY,Groopman JE

Mon May 06 00:00:00 EDT 2013

DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.

PloS one

Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H

Thu Nov 08 00:00:00 EST 2012

Divergent effects of mycobacterial cell wall glycolipids on maturation and function of human monocyte-derived dendritic cells.

PloS one

Mazurek J,Ignatowicz L,Kallenius G,Svenson SB,Pawlowski A,Hamasur B

Thu Jan 10 00:00:00 EST 2013

Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells.

PloS one

Dolganiuc A,Kodys K,Marshall C,Saha B,Zhang S,Bala S,Szabo G

Tue Apr 02 00:00:00 EDT 2013

Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.

PloS one

Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC

Fri Jun 29 00:00:00 EDT 2012

Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).

PloS one

Suh HS,Choi N,Tarassishin L,Lee SC

Tue Aug 07 00:00:00 EDT 2012

TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets.

Clinical & developmental immunology

Straetemans T,van Brakel M,van Steenbergen S,Broertjes M,Drexhage J,Hegmans J,Lambrecht BN,Lamers C,van Der Bruggen P,Coulie PG,Debets R

Fri Mar 01 00:00:00 EST 2013

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

The Journal of biological chemistry

Lohse S,Brunke C,Derer S,Peipp M,Boross P,Kellner C,Beyer T,Dechant M,van der Winkel JG,Leusen JH,Valerius T

Fri Jul 20 00:00:00 EDT 2012

Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity.

Aging

Agrawal A,Su H,Chen J,Osann K,Agrawal S,Gupta S

Sat Sep 01 00:00:00 EDT 2012

MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.

PloS one

Testa JS,Shetty V,Hafner J,Nickens Z,Kamal S,Sinnathamby G,Philip R

Wed Apr 24 00:00:00 EDT 2013

Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons.

Scientific reports

Cobos Jiménez V,Booiman T,de Taeye SW,van Dort KA,Rits MA,Hamann J,Kootstra NA

Thu Mar 21 00:00:00 EDT 2013

Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.

The Journal of biological chemistry

Müller JR,Waldmann TA,Kruhlak MJ,Dubois S

Fri Nov 23 00:00:00 EST 2012

Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype.

Journal of biomedicine & biotechnology

Silk KM,Leishman AJ,Nishimoto KP,Reddy A,Fairchild PJ

Fri Sep 07 00:00:00 EDT 2012

Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors.

The Journal of biological chemistry

Comas-Casellas E,Martínez-Barriocanal Á,Miró F,Ejarque-Ortiz A,Schwartz S,Martín M,Sayós J

Fri Mar 23 00:00:00 EDT 2012

IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.

The Journal of biological chemistry

Bachmann M,Scheiermann P,Härdle L,Pfeilschifter J,Mühl H

Fri Dec 07 00:00:00 EST 2012

Neuroimmunoendocrine regulation of the prion protein in neutrophils.

The Journal of biological chemistry

Mariante RM,Nóbrega A,Martins RAP,Areal RB,Bellio M,Linden R

Fri Oct 12 00:00:00 EDT 2012

Identifying functional microRNAs in macrophages with polarized phenotypes.

The Journal of biological chemistry

Graff JW,Dickson AM,Clay G,McCaffrey AP,Wilson ME

Fri Jun 22 00:00:00 EDT 2012

Enhancement of myeloma development mediated though myeloma cell-Th2 cell interactions after microbial antigen presentation by myeloma cells and DCs.

Blood cancer journal

Tian F,Li J,Li Y,Luo S

Fri Jun 01 00:00:00 EDT 2012

Molecular mimics of the tumour antigen MUC1.

PloS one

James TC,Bond U

Thu Jun 20 00:00:00 EDT 2013

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

Immunity

Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A

Fri Dec 23 00:00:00 EST 2011

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.

Blood

Bosco MC,Pierobon D,Blengio F,Raggi F,Vanni C,Gattorno M,Eva A,Novelli F,Cappello P,Giovarelli M,Varesio L

Thu Mar 03 00:00:00 EST 2011

Monocytes from HTLV-1-infected patients are unable to fully mature into dendritic cells.

Blood

Nascimento CR,Lima MA,de Andrada Serpa MJ,Espindola O,Leite AC,Echevarria-Lima J

Thu Jan 13 00:00:00 EST 2011

IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.

Blood

Bondanza A,Hambach L,Aghai Z,Nijmeijer B,Kaneko S,Mastaglio S,Radrizzani M,Fleischhauer K,Ciceri F,Bordignon C,Bonini C,Goulmy E

Thu Jun 16 00:00:00 EDT 2011

Natural killer cells expressing the KIR2DS1-activating receptor efficiently kill T-cell blasts and dendritic cells: implications in haploidentical HSCT.

Blood

Sivori S,Carlomagno S,Falco M,Romeo E,Moretta L,Moretta A

Thu Apr 21 00:00:00 EDT 2011

STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.

Blood

Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E

Thu Jan 06 00:00:00 EST 2011

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.

Blood

Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ

Thu Sep 01 00:00:00 EDT 2011

Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors.

Blood

Bonetti MI,Pieri L,Domenici L,Urbani S,Romano G,Aldinucci A,Ballerini C,Monici M,Saccardi R,Basile V,Bosi A,Romagnoli P

Thu Apr 14 00:00:00 EDT 2011

Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells.

Blood

Carlier J,Martin H,Mariamé B,Rauwel B,Mengelle C,Weclawiak H,Coaquette A,Vauchy C,Rohrlich P,Kamar N,Rostaing L,Herbein G,Davrinche C

Thu Dec 22 00:00:00 EST 2011

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.

The Journal of clinical investigation

Sindrilaru A,Peters T,Wieschalka S,Baican C,Baican A,Peter H,Hainzl A,Schatz S,Qi Y,Schlecht A,Weiss JM,Wlaschek M,Sunderkötter C,Scharffetter-Kochanek K

Tue Mar 01 00:00:00 EST 2011

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.

The Journal of experimental medicine

Séror C,Melki MT,Subra F,Raza SQ,Bras M,Saïdi H,Nardacci R,Voisin L,Paoletti A,Law F,Martins I,Amendola A,Abdul-Sater AA,Ciccosanti F,Delelis O,Niedergang F,Thierry S,Said-Sadier N,Lamaze C,Métivier D,Estaquier J,Fimia GM,Falasca L,Casetti R,Modjtahedi N,Kanellopoulos J,Mouscadet JF,Ojcius DM,Piacentini M,Gougeon ML,Kroemer G,Perfettini JL

Mon Aug 29 00:00:00 EDT 2011

In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates.

The Journal of experimental medicine

Jung KC,Park CG,Jeon YK,Park HJ,Ban YL,Min HS,Kim EJ,Kim JH,Kang BH,Park SP,Bae Y,Yoon IH,Kim YH,Lee JI,Kim JS,Shin JS,Yang J,Kim SJ,Rostlund E,Muller WA,Park SH

Mon Nov 21 00:00:00 EST 2011

Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.

The Journal of experimental medicine

Saito M,Nagasawa M,Takada H,Hara T,Tsuchiya S,Agematsu K,Yamada M,Kawamura N,Ariga T,Tsuge I,Nonoyama S,Karasuyama H,Minegishi Y

Mon Feb 14 00:00:00 EST 2011

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.

Nature protocols

Choi KD,Vodyanik M,Slukvin II

Tue Mar 01 00:00:00 EST 2011

The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.

PLoS pathogens

Varga ZT,Ramos I,Hai R,Schmolke M,García-Sastre A,Fernandez-Sesma A,Palese P

Wed Jun 01 00:00:00 EDT 2011

Effects of receptor binding specificity of avian influenza virus on the human innate immune response.

Journal of virology

Ramos I,Bernal-Rubio D,Durham N,Belicha-Villanueva A,Lowen AC,Steel J,Fernandez-Sesma A

Sun May 01 00:00:00 EDT 2011

Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms.

Stem cells (Dayton, Ohio)

Su WR,Zhang QZ,Shi SH,Nguyen AL,Le AD

Tue Nov 01 00:00:00 EDT 2011

Human TCR transgenic Bet v 1-specific Th1 cells suppress the effector function of Bet v 1-specific Th2 cells.

Journal of immunology (Baltimore, Md. : 1950)

Neunkirchner A,Leb-Reichl VM,Schmetterer KG,Mutschlechner S,Kueng HJ,Haiderer D,Schuch K,Wallner M,Jahn-Schmid B,Bohle B,Pickl WF

Sat Oct 15 00:00:00 EDT 2011

Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction.

Journal of immunology (Baltimore, Md. : 1950)

Kim YJ,Park SJ,Broxmeyer HE

Thu Sep 01 00:00:00 EDT 2011

Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors.

Journal of immunology (Baltimore, Md. : 1950)

Iwata-Kajihara T,Sumimoto H,Kawamura N,Ueda R,Takahashi T,Mizuguchi H,Miyagishi M,Takeda K,Kawakami Y

Fri Jul 01 00:00:00 EDT 2011

Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10.

Journal of immunology (Baltimore, Md. : 1950)

Svensson J,Jenmalm MC,Matussek A,Geffers R,Berg G,Ernerudh J

Sat Oct 01 00:00:00 EDT 2011

IFN-β mediates suppression of IL-12p40 in human dendritic cells following infection with virulent Francisella tularensis.

Journal of immunology (Baltimore, Md. : 1950)

Bauler TJ,Chase JC,Bosio CM

Mon Aug 15 00:00:00 EDT 2011

A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist.

Journal of immunology (Baltimore, Md. : 1950)

Wiemer AJ,Hegde S,Gumperz JE,Huttenlocher A

Sat Oct 01 00:00:00 EDT 2011

Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.

Journal of immunology (Baltimore, Md. : 1950)

Shetty S,Weston CJ,Oo YH,Westerlund N,Stamataki Z,Youster J,Hubscher SG,Salmi M,Jalkanen S,Lalor PF,Adams DH

Fri Apr 01 00:00:00 EDT 2011

Peroxisome proliferator-activated receptor γ-regulated cathepsin D is required for lipid antigen presentation by dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Nakken B,Varga T,Szatmari I,Szeles L,Gyongyosi A,Illarionov PA,Dezso B,Gogolak P,Rajnavolgyi E,Nagy L

Fri Jul 01 00:00:00 EDT 2011

Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.

Journal of immunology (Baltimore, Md. : 1950)

Okano S,Yonemitsu Y,Shirabe K,Kakeji Y,Maehara Y,Harada M,Yoshikai Y,Inoue M,Hasegawa M,Sueishi K

Tue Feb 01 00:00:00 EST 2011

HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Muthumani K,Shedlock DJ,Choo DK,Fagone P,Kawalekar OU,Goodman J,Bian CB,Ramanathan AA,Atman P,Tebas P,Chattergoon MA,Choo AY,Weiner DB

Thu Sep 15 00:00:00 EDT 2011

Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus.

Journal of immunology (Baltimore, Md. : 1950)

Horton HM,Chu SY,Ortiz EC,Pong E,Cemerski S,Leung IW,Jacob N,Zalevsky J,Desjarlais JR,Stohl W,Szymkowski DE

Fri Apr 01 00:00:00 EDT 2011

Thymic stromal lymphopoietin is produced by dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Kashyap M,Rochman Y,Spolski R,Samsel L,Leonard WJ

Mon Aug 01 00:00:00 EDT 2011

Platelet-activating factor induces Th17 cell differentiation.

Mediators of inflammation

Drolet AM,Thivierge M,Turcotte S,Hanna D,Maynard B,Stankovà J,Rola-Pleszczynski M

Tue May 15 00:00:00 EDT 2012

The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I).

Cellular immunology

Hölzl MA,Hofer J,Kovarik JJ,Roggenbuck D,Reinhold D,Goihl A,Gärtner M,Steinberger P,Zlabinger GJ

Mon Apr 18 00:00:00 EDT 2011

Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function.

BMC infectious diseases

Wu Y,Mao H,Ling MT,Chow KH,Ho PL,Tu W,Lau YL

Wed Jul 20 00:00:00 EDT 2011

Lipoglycans contribute to innate immune detection of mycobacteria.

PloS one

Krishna S,Ray A,Dubey SK,Larrouy-Maumus G,Chalut C,Castanier R,Noguera A,Gilleron M,Puzo G,Vercellone A,Nampoothiri KM,Nigou J

Fri Jul 20 00:00:00 EDT 2012

Mature autologous dendritic cell vaccines in advanced non-small cell lung cancer: a phase I pilot study.

Journal of experimental & clinical cancer research : CR

Perroud MW,Honma HN,Barbeiro AS,Gilli SC,Almeida MT,Vassallo J,Saad ST,Zambon L

Fri Jun 17 00:00:00 EDT 2011

Efficient activation of T cells by human monocyte-derived dendritic cells (HMDCs) pulsed with Coxiella burnetii outer membrane protein Com1 but not by HspB-pulsed HMDCs.

BMC immunology

Wang Y,Xiong X,Wu D,Wang X,Wen B

Sat Sep 03 00:00:00 EDT 2011

Mannan-binding lectin regulates dendritic cell maturation and cytokine production induced by lipopolysaccharide.

BMC immunology

Wang M,Zhang Y,Chen Y,Zhang L,Lu X,Chen Z

Sat Jan 01 00:00:00 EST 2011

Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials.

Journal of translational medicine

Fučíková J,Rožková D,Ulčová H,Budinský V,Sochorová K,Pokorná K,Bartůňková J,Špíšek R

Fri Dec 30 00:00:00 EST 2011

IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides.

Respiratory research

Zuyderduyn S,Ninaber DK,Schrumpf JA,van Sterkenburg MA,Verhoosel RM,Prins FA,van Wetering S,Rabe KF,Hiemstra PS

Mon May 02 00:00:00 EDT 2011

TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells.

The Journal of biological chemistry

Keller CW,Fokken C,Turville SG,Lünemann A,Schmidt J,Münz C,Lünemann JD

Fri Feb 04 00:00:00 EST 2011

Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate.

Journal of translational medicine

Chiang CL,Maier DA,Kandalaft LE,Brennan AL,Lanitis E,Ye Q,Levine BL,Czerniecki BJ,Powell DJ,Coukos G

Mon Nov 14 00:00:00 EST 2011

Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy.

Journal of translational medicine

Ma W,Smith T,Bogin V,Zhang Y,Ozkan C,Ozkan M,Hayden M,Schroter S,Carrier E,Messmer D,Kumar V,Minev B

Thu Mar 31 00:00:00 EDT 2011

Modulation of human immune responses by bovine interleukin-10.

PloS one

den Hartog G,Savelkoul HF,Schoemaker R,Tijhaar E,Westphal AH,de Ruiter T,van de Weg-Schrijver E,van Neerven RJ

Fri Mar 25 00:00:00 EDT 2011

Modulation of human immune responses by bovine interleukin-10.

PloS one

den Hartog G,Savelkoul HF,Schoemaker R,Tijhaar E,Westphal AH,de Ruiter T,van de Weg-Schrijver E,van Neerven RJ

Fri Mar 25 00:00:00 EDT 2011

Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients.

PloS one

Lasigliè D,Traggiai E,Federici S,Alessio M,Buoncompagni A,Accogli A,Chiesa S,Penco F,Martini A,Gattorno M

Thu Sep 29 00:00:00 EDT 2011

Broad antiviral activity of carbohydrate-binding agents against the four serotypes of dengue virus in monocyte-derived dendritic cells.

PloS one

Alen MM,De Burghgraeve T,Kaptein SJ,Balzarini J,Neyts J,Schols D

Thu Dec 01 00:00:00 EST 2011

Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen.

Reproductive biology and endocrinology : RB&E

Escribese MM,Rodríguez-García M,Sperling R,Engel SM,Gallart T,Moran TM

Tue Aug 23 00:00:00 EDT 2011

Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis.

The Journal of biological chemistry

Kamata Y,Yamamoto M,Kawakami F,Tsuboi R,Takeda A,Ishihara K,Hibino T

Fri Mar 11 00:00:00 EST 2011

PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1.

The Journal of biological chemistry

Dong L,Zhang X,Fu X,Zhang X,Gao X,Zhu M,Wang X,Yang Z,Jensen ON,Saarikettu J,Yao Z,Silvennoinen O,Yang J

Fri Feb 04 00:00:00 EST 2011

The therapeutic effect of cytokine-induced killer cells on pancreatic cancer enhanced by dendritic cells pulsed with K-ras mutant peptide.

Clinical & developmental immunology

Tan G,Zhang X,Feng H,Luo H,Wang Z

Wed Jun 06 00:00:00 EDT 2012

KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation.

PloS one

Hanvesakul R,Kubal C,Moore J,Neil D,Cook M,Ball S,Briggs D,Moss P,Cockwell P

Fri Dec 23 00:00:00 EST 2011

Deactivation of STAT6 through serine 707 phosphorylation by JNK.

The Journal of biological chemistry

Shirakawa T,Kawazoe Y,Tsujikawa T,Jung D,Sato S,Uesugi M

Fri Feb 04 00:00:00 EST 2011

Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells.

Journal of biological engineering

Tai A,Froelich S,Joo KI,Wang P

Fri Jan 28 00:00:00 EST 2011

Cytokine-based high log-scale expansion of functional human dendritic cells from cord-blood CD34-positive cells.

Scientific reports

Harada Y,Okada-Nakanishi Y,Ueda Y,Tsujitani S,Saito S,Fuji-Ogawa T,Iida A,Hasegawa M,Ichikawa T,Yonemitsu Y

Tue Sep 10 00:00:00 EDT 2013

Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells.

Journal of neuroinflammation

Dao MA,Tate CC,Aizman I,McGrogan M,Case CC

Fri Oct 07 00:00:00 EDT 2011

MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4.

The Journal of biological chemistry

Tserel L,Runnel T,Kisand K,Pihlap M,Bakhoff L,Kolde R,Peterson H,Vilo J,Peterson P,Rebane A

Fri Jul 29 00:00:00 EDT 2011

IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.

PloS one

Sammicheli S,Dang VP,Ruffin N,Pham HT,Lantto R,Vivar N,Chiodi F,Rethi B

Mon Aug 27 00:00:00 EDT 2012

Day-4 myeloid dendritic cells pulsed with whole tumor lysate are highly immunogenic and elicit potent anti-tumor responses.

PloS one

Chiang CL,Hagemann AR,Leskowitz R,Mick R,Garrabrant T,Czerniecki BJ,Kandalaft LE,Powell DJ,Coukos G

Mon Aug 27 00:00:00 EDT 2012

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.

The Journal of biological chemistry

Watanabe A,Tatematsu M,Saeki K,Shibata S,Shime H,Yoshimura A,Obuse C,Seya T,Matsumoto M

Fri Mar 25 00:00:00 EDT 2011

GATA3 expression is decreased in psoriasis and during epidermal regeneration; induction by narrow-band UVB and IL-4.

PloS one

Rácz E,Kurek D,Kant M,Baerveldt EM,Florencia E,Mourits S,de Ridder D,Laman JD,van der Fits L,Prens EP

Mon Sep 12 00:00:00 EDT 2011

High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation.

PloS one

Maharjan AS,Pilling D,Gomer RH

Fri Feb 17 00:00:00 EST 2012

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia.

Nature

Cavazzana-Calvo M,Payen E,Negre O,Wang G,Hehir K,Fusil F,Down J,Denaro M,Brady T,Westerman K,Cavallesco R,Gillet-Legrand B,Caccavelli L,Sgarra R,Maouche-Chrétien L,Bernaudin F,Girot R,Dorazio R,Mulder GJ,Polack A,Bank A,Soulier J,Larghero J,Kabbara N,Dalle B,Gourmel B,Socie G,Chrétien S,Cartier N,Aubourg P,Fischer A,Cornetta K,Galacteros F,Beuzard Y,Gluckman E,Bushman F,Hacein-Bey-Abina S,Leboulch P

Thu Sep 16 00:00:00 EDT 2010

STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.

Immunity

Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L

Wed Nov 24 00:00:00 EST 2010

IRF5 is required for late-phase TNF secretion by human dendritic cells.

Blood

Krausgruber T,Saliba D,Ryzhakov G,Lanfrancotti A,Blazek K,Udalova IA

Thu Jun 03 00:00:00 EDT 2010

Human fibroblasts support the expansion of IL-17-producing T cells via up-regulation of IL-23 production by dendritic cells.

Blood

Schirmer C,Klein C,von Bergen M,Simon JC,Saalbach A

Thu Sep 09 00:00:00 EDT 2010

Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits.

Blood

Valeri VW,Hryniewicz A,Andresen V,Jones K,Fenizia C,Bialuk I,Chung HK,Fukumoto R,Parks RW,Ferrari MG,Nicot C,Cecchinato V,Ruscetti F,Franchini G

Thu Nov 11 00:00:00 EST 2010

Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.

Blood

Tewary P,Yang D,de la Rosa G,Li Y,Finn MW,Krensky AM,Clayberger C,Oppenheim JJ

Thu Nov 04 00:00:00 EDT 2010

Beyond the enhanceosome: cluster of novel κB sites downstream of the human IFN-β gene is essential for lipopolysaccharide-induced gene activation.

Blood

Goh FG,Thomson SJ,Krausgruber T,Lanfrancotti A,Copley RR,Udalova IA

Thu Dec 16 00:00:00 EST 2010

Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma.

Blood

Racanelli V,Leone P,Frassanito MA,Brunetti C,Perosa F,Ferrone S,Dammacco F

Thu Feb 11 00:00:00 EST 2010

Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans.

Blood

Guo PF,Du MR,Wu HX,Lin Y,Jin LP,Li DJ

Thu Sep 23 00:00:00 EDT 2010

ATP secreted by endothelial cells blocks CX₃CL 1-elicited natural killer cell chemotaxis and cytotoxicity via P2Y₁₁ receptor activation.

Blood

Gorini S,Callegari G,Romagnoli G,Mammi C,Mavilio D,Rosano G,Fini M,Di Virgilio F,Gulinelli S,Falzoni S,Cavani A,Ferrari D,la Sala A

Thu Nov 25 00:00:00 EST 2010

Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis.

The Journal of clinical investigation

Kreindler JL,Steele C,Nguyen N,Chan YR,Pilewski JM,Alcorn JF,Vyas YM,Aujla SJ,Finelli P,Blanchard M,Zeigler SF,Logar A,Hartigan E,Kurs-Lasky M,Rockette H,Ray A,Kolls JK

Wed Sep 01 00:00:00 EDT 2010

Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.

The Journal of experimental medicine

Orthwein A,Patenaude AM,Affar el B,Lamarre A,Young JC,Di Noia JM

Mon Nov 22 00:00:00 EST 2010

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.

Proceedings of the National Academy of Sciences of the United States of America

Rochman Y,Kashyap M,Robinson GW,Sakamoto K,Gomez-Rodriguez J,Wagner KU,Leonard WJ

Tue Nov 09 00:00:00 EST 2010

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism.

Proceedings of the National Academy of Sciences of the United States of America

Edfeldt K,Liu PT,Chun R,Fabri M,Schenk M,Wheelwright M,Keegan C,Krutzik SR,Adams JS,Hewison M,Modlin RL

Tue Dec 28 00:00:00 EST 2010

Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells.

Proceedings of the National Academy of Sciences of the United States of America

Meuter S,Eberl M,Moser B

Tue May 11 00:00:00 EDT 2010

IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter.

Proceedings of the National Academy of Sciences of the United States of America

Kis LL,Salamon D,Persson EK,Nagy N,Scheeren FA,Spits H,Klein G,Klein E

Tue Jan 12 00:00:00 EST 2010

Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection.

Proceedings of the National Academy of Sciences of the United States of America

Takahashi K,Asabe S,Wieland S,Garaigorta U,Gastaminza P,Isogawa M,Chisari FV

Tue Apr 20 00:00:00 EDT 2010

Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells.

The Journal of investigative dermatology

Kagatani S,Sasaki Y,Hirota M,Mizuashi M,Suzuki M,Ohtani T,Itagaki H,Aiba S

Fri Jan 01 00:00:00 EST 2010

Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1.

PLoS pathogens

Melki MT,Saïdi H,Dufour A,Olivo-Marin JC,Gougeon ML

Thu Apr 15 00:00:00 EDT 2010

Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes.

PLoS pathogens

Tabouret G,Astarie-Dequeker C,Demangel C,Malaga W,Constant P,Ray A,Honoré N,Bello NF,Perez E,Daffé M,Guilhot C

Thu Oct 21 00:00:00 EDT 2010

A novel pseudopodial component of the dendritic cell anti-fungal response: the fungipod.

PLoS pathogens

Neumann AK,Jacobson K

Fri Feb 12 00:00:00 EST 2010

PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection.

PLoS pathogens

Hanley TM,Blay Puryear W,Gummuluru S,Viglianti GA

Thu Jul 01 00:00:00 EDT 2010

Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing.

Stem cells (Dayton, Ohio)

Zhang QZ,Su WR,Shi SH,Wilder-Smith P,Xiang AP,Wong A,Nguyen AL,Kwon CW,Le AD

Fri Oct 01 00:00:00 EDT 2010

Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism.

Journal of immunology (Baltimore, Md. : 1950)

Elsheikh A,Lavergne SN,Castrejon JL,Farrell J,Wang H,Sathish J,Pichler WJ,Park BK,Naisbitt DJ

Wed Dec 01 00:00:00 EST 2010

Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin.

Journal of immunology (Baltimore, Md. : 1950)

Bleck B,Tse DB,Gordon T,Ahsan MR,Reibman J

Wed Dec 01 00:00:00 EST 2010

A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Hu J,Nistal-Villán E,Voho A,Ganee A,Kumar M,Ding Y,García-Sastre A,Wetmur JG

Thu Jul 01 00:00:00 EDT 2010

Escherichia coli K1 promotes the ligation of CD47 with thrombospondin-1 to prevent the maturation of dendritic cells in the pathogenesis of neonatal meningitis.

Journal of immunology (Baltimore, Md. : 1950)

Mittal R,Gonzalez-Gomez I,Prasadarao NV

Wed Sep 01 00:00:00 EDT 2010

A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Haidinger M,Poglitsch M,Geyeregger R,Kasturi S,Zeyda M,Zlabinger GJ,Pulendran B,Hörl WH,Säemann MD,Weichhart T

Fri Oct 01 00:00:00 EDT 2010

Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells.

Journal of immunology (Baltimore, Md. : 1950)

Esmann L,Idel C,Sarkar A,Hellberg L,Behnen M,Möller S,van Zandbergen G,Klinger M,Köhl J,Bussmeyer U,Solbach W,Laskay T

Fri Jan 01 00:00:00 EST 2010

Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli.

Journal of immunology (Baltimore, Md. : 1950)

Töröcsik D,Baráth M,Benko S,Széles L,Dezso B,Póliska S,Hegyi Z,Homolya L,Szatmári I,Lányi A,Nagy L

Sat May 15 00:00:00 EDT 2010

Antiviral response dictated by choreographed cascade of transcription factors.

Journal of immunology (Baltimore, Md. : 1950)

Zaslavsky E,Hershberg U,Seto J,Pham AM,Marquez S,Duke JL,Wetmur JG,Tenoever BR,Sealfon SC,Kleinstein SH

Mon Mar 15 00:00:00 EDT 2010

IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

Macey MR,Sturgill JL,Morales JK,Falanga YT,Morales J,Norton SK,Yerram N,Shim H,Fernando J,Gifillan AM,Gomez G,Schwartz L,Oskeritzian C,Spiegel S,Conrad D,Ryan JJ

Sat May 01 00:00:00 EDT 2010

Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE.

Journal of immunology (Baltimore, Md. : 1950)

Vossenkämper A,Marchès O,Fairclough PD,Warnes G,Stagg AJ,Lindsay JO,Evans PC,Luong le A,Croft NM,Naik S,Frankel G,MacDonald TT

Fri Oct 01 00:00:00 EDT 2010

Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility.

Journal of immunology (Baltimore, Md. : 1950)

Solinas G,Schiarea S,Liguori M,Fabbri M,Pesce S,Zammataro L,Pasqualini F,Nebuloni M,Chiabrando C,Mantovani A,Allavena P

Thu Jul 01 00:00:00 EDT 2010

Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions.

Journal of immunology (Baltimore, Md. : 1950)

Csillag A,Boldogh I,Pazmandi K,Magyarics Z,Gogolak P,Sur S,Rajnavolgyi E,Bacsi A

Mon Mar 01 00:00:00 EST 2010

Unique epitopes on C epsilon mX in IgE-B cell receptors are potentially applicable for targeting IgE-committed B cells.

Journal of immunology (Baltimore, Md. : 1950)

Chen JB,Wu PC,Hung AF,Chu CY,Tsai TF,Yu HM,Chang HY,Chang TW

Mon Feb 15 00:00:00 EST 2010

Enhanced activation of T lymphocytes by urease-deficient recombinant bacillus Calmette-Guérin producing heat shock protein 70-major membrane protein-II fusion protein.

Journal of immunology (Baltimore, Md. : 1950)

Mukai T,Maeda Y,Tamura T,Matsuoka M,Tsukamoto Y,Makino M

Mon Nov 15 00:00:00 EST 2010

Transcription factor E2F1 suppresses dendritic cell maturation.

Journal of immunology (Baltimore, Md. : 1950)

Fang F,Wang Y,Li R,Zhao Y,Guo Y,Jiang M,Sun J,Ma Y,Ren Z,Tian Z,Wei F,Yang D,Xiao W

Tue Jun 01 00:00:00 EDT 2010

Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens.

Journal of immunology (Baltimore, Md. : 1950)

Cernadas M,Cavallari M,Watts G,Mori L,De Libero G,Brenner MB

Mon Feb 01 00:00:00 EST 2010

miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.

Journal of immunology (Baltimore, Md. : 1950)

Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H

Sat May 01 00:00:00 EDT 2010

Expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower CCR1 expression.

Journal of immunology (Baltimore, Md. : 1950)

Semnani RT,Mahapatra L,Dembele B,Konate S,Metenou S,Dolo H,Coulibaly ME,Soumaoro L,Coulibaly SY,Sanogo D,Seriba Doumbia S,Diallo AA,Traoré SF,Klion A,Nutman TB,Mahanty S

Mon Nov 15 00:00:00 EST 2010

A threonine-based targeting signal in the human CD1d cytoplasmic tail controls its functional expression.

Journal of immunology (Baltimore, Md. : 1950)

Liu J,Shaji D,Cho S,Du W,Gervay-Hague J,Brutkiewicz RR

Sat May 01 00:00:00 EDT 2010

Age-associated epigenetic modifications in human DNA increase its immunogenicity.

Aging

Agrawal A,Tay J,Yang GE,Agrawal S,Gupta S

Sat Mar 20 00:00:00 EDT 2010

Immunostimulatory properties of dendritic cells after Leishmania donovani infection using an in vitro model of liver microenvironment.

PLoS neglected tropical diseases

Donaghy L,Cabillic F,Corlu A,Rostan O,Toutirais O,Guguen-Guillouzo C,Guiguen C,Gangneux JP

Tue Jun 08 00:00:00 EDT 2010

Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus.

The Journal of biological chemistry

Walseng E,Furuta K,Goldszmid RS,Weih KA,Sher A,Roche PA

Fri Dec 31 00:00:00 EST 2010

A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers.

The Journal of biological chemistry

Riemer AB,Keskin DB,Zhang G,Handley M,Anderson KS,Brusic V,Reinhold B,Reinherz EL

Fri Sep 17 00:00:00 EDT 2010

Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4.

The Journal of biological chemistry

Wilkie S,Burbridge SE,Chiapero-Stanke L,Pereira AC,Cleary S,van der Stegen SJ,Spicer JF,Davies DM,Maher J

Fri Aug 13 00:00:00 EDT 2010

The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus.

PloS one

Ben-Zvi I,Aranow C,Mackay M,Stanevsky A,Kamen DL,Marinescu LM,Collins CE,Gilkeson GS,Diamond B,Hardin JA

Tue Feb 16 00:00:00 EST 2010

Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells.

PloS one

Ochiel DO,Ochsenbauer C,Kappes JC,Ghosh M,Fahey JV,Wira CR

Tue Dec 14 00:00:00 EST 2010

Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.

The Journal of biological chemistry

Mao AP,Li S,Zhong B,Li Y,Yan J,Li Q,Teng C,Shu HB

Fri Mar 26 00:00:00 EDT 2010

Human dendritic cells activated via dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses.

PloS one

Agrawal S,Gupta S,Agrawal A

Mon Oct 18 00:00:00 EDT 2010

miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy.

Journal of translational medicine

Sasaki K,Kohanbash G,Hoji A,Ueda R,McDonald HA,Reinhart TA,Martinson J,Lotze MT,Marincola FM,Wang E,Fujita M,Okada H

Thu Feb 18 00:00:00 EST 2010

Differential effects of Paclitaxel on dendritic cell function.

BMC immunology

John J,Ismail M,Riley C,Askham J,Morgan R,Melcher A,Pandha H

Fri Mar 19 00:00:00 EDT 2010

Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity.

Journal of inflammation (London, England)

Jensen SS,Gad M

Tue Jul 27 00:00:00 EDT 2010

Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses.

The Journal of biological chemistry

Thoh M,Kumar P,Nagarajaram HA,Manna SK

Fri Feb 19 00:00:00 EST 2010

Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.

Clinical and molecular allergy : CMA

Knutsen AP,Vijay HM,Kariuki B,Santiago LA,Graff R,Wofford JD,Shah MR

Thu Mar 18 00:00:00 EDT 2010

A pilot clinical trial testing mutant von Hippel-Lindau peptide as a novel immune therapy in metastatic renal cell carcinoma.

Journal of translational medicine

Rahma OE,Ashtar E,Ibrahim R,Toubaji A,Gause B,Herrin VE,Linehan WM,Steinberg SM,Grollman F,Grimes G,Bernstein SA,Berzofsky JA,Khleif SN

Thu Jan 28 00:00:00 EST 2010

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.

Immunity

Zhong B,Zhang L,Lei C,Li Y,Mao AP,Yang Y,Wang YY,Zhang XL,Shu HB

Fri Mar 20 00:00:00 EDT 2009

Impaired development of human Th1 cells in patients with deficient expression of STAT4.

Blood

Chang HC,Han L,Goswami R,Nguyen ET,Pelloso D,Robertson MJ,Kaplan MH

Thu Jun 04 00:00:00 EDT 2009

MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2.

Blood

Spaggiari GM,Abdelrazik H,Becchetti F,Moretta L

Thu Jun 25 00:00:00 EDT 2009

Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs.

Blood

Aichberger KJ,Gleixner KV,Mirkina I,Cerny-Reiterer S,Peter B,Ferenc V,Kneidinger M,Baumgartner C,Mayerhofer M,Gruze A,Pickl WF,Sillaber C,Valent P

Thu Dec 17 00:00:00 EST 2009

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes.

Blood

Van den Bossche J,Bogaert P,van Hengel J,Guérin CJ,Berx G,Movahedi K,Van den Bergh R,Pereira-Fernandes A,Geuns JM,Pircher H,Dorny P,Grooten J,De Baetselier P,Van Ginderachter JA

Thu Nov 19 00:00:00 EST 2009

HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1.

Blood

Anand AR,Prasad A,Bradley RR,Deol YS,Nagaraja T,Ren X,Terwilliger EF,Ganju RK

Thu Oct 22 00:00:00 EDT 2009

High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia.

Blood

Herling M,Patel KA,Weit N,Lilienthal N,Hallek M,Keating MJ,Jones D

Thu Nov 19 00:00:00 EST 2009

Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation.

Blood

Göbel F,Taschner S,Jurkin J,Konradi S,Vaculik C,Richter S,Kneidinger D,Mühlbacher C,Bieglmayer C,Elbe-Bürger A,Strobl H

Thu Oct 29 00:00:00 EDT 2009

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells.

Blood

Dai J,Megjugorac NJ,Gallagher GE,Yu RY,Gallagher G

Thu Jun 04 00:00:00 EDT 2009

Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3.

The Journal of experimental medicine

Iwakiri D,Zhou L,Samanta M,Matsumoto M,Ebihara T,Seya T,Imai S,Fujieda M,Kawa K,Takada K

Mon Sep 28 00:00:00 EDT 2009

Characterization and regulation of bv8 in human blood cells.

Clinical cancer research : an official journal of the American Association for Cancer Research

Zhong C,Qu X,Tan M,Meng YG,Ferrara N

Wed Apr 15 00:00:00 EDT 2009

Impaired STAT phosphorylation in T cells from melanoma patients in response to IL-2: association with clinical stage.

Clinical cancer research : an official journal of the American Association for Cancer Research

Mortarini R,Vegetti C,Molla A,Arienti F,Ravagnani F,Maurichi A,Patuzzo R,Santinami M,Anichini A

Mon Jun 15 00:00:00 EDT 2009

Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells.

Cancer research

Kawabe M,Mandic M,Taylor JL,Vasquez CA,Wesa AK,Neckers LM,Storkus WJ

Tue Sep 01 00:00:00 EDT 2009

Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles.

Leukemia

Plander M,Seegers S,Ugocsai P,Diermeier-Daucher S,Iványi J,Schmitz G,Hofstädter F,Schwarz S,Orsó E,Knüchel R,Brockhoff G

Sun Nov 01 00:00:00 EDT 2009

Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition.

Proceedings of the National Academy of Sciences of the United States of America

Nicholls S,Piper KP,Mohammed F,Dafforn TR,Tenzer S,Salim M,Mahendra P,Craddock C,van Endert P,Schild H,Cobbold M,Engelhard VH,Moss PA,Willcox BE

Tue Mar 10 00:00:00 EDT 2009

Salmonella regulates polyubiquitination and surface expression of MHC class II antigens.

Proceedings of the National Academy of Sciences of the United States of America

Lapaque N,Hutchinson JL,Jones DC,Méresse S,Holden DW,Trowsdale J,Kelly AP

Tue Aug 18 00:00:00 EDT 2009

The role of transposable elements in the regulation of IFN-lambda1 gene expression.

Proceedings of the National Academy of Sciences of the United States of America

Thomson SJ,Goh FG,Banks H,Krausgruber T,Kotenko SV,Foxwell BM,Udalova IA

Tue Jul 14 00:00:00 EDT 2009

Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses.

Proceedings of the National Academy of Sciences of the United States of America

Brandes M,Willimann K,Bioley G,Lévy N,Eberl M,Luo M,Tampé R,Lévy F,Romero P,Moser B

Tue Feb 17 00:00:00 EST 2009

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

Proceedings of the National Academy of Sciences of the United States of America

Porta C,Rimoldi M,Raes G,Brys L,Ghezzi P,Di Liberto D,Dieli F,Ghisletti S,Natoli G,De Baetselier P,Mantovani A,Sica A

Tue Sep 01 00:00:00 EDT 2009

Identification of tumor-associated, MHC class II-restricted phosphopeptides as targets for immunotherapy.

Proceedings of the National Academy of Sciences of the United States of America

Depontieu FR,Qian J,Zarling AL,McMiller TL,Salay TM,Norris A,English AM,Shabanowitz J,Engelhard VH,Hunt DF,Topalian SL

Tue Jul 21 00:00:00 EDT 2009

MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells.

Proceedings of the National Academy of Sciences of the United States of America

Ceppi M,Pereira PM,Dunand-Sauthier I,Barras E,Reith W,Santos MA,Pierre P

Tue Feb 24 00:00:00 EST 2009

A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.

PLoS pathogens

Eberl M,Roberts GW,Meuter S,Williams JD,Topley N,Moser B

Sun Feb 01 00:00:00 EST 2009

Human NKT cells promote monocyte differentiation into suppressive myeloid antigen-presenting cells.

Journal of leukocyte biology

Hegde S,Jankowska-Gan E,Roenneburg DA,Torrealba J,Burlingham WJ,Gumperz JE

Thu Oct 01 00:00:00 EDT 2009

Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy.

Cancer gene therapy

Tosch C,Geist M,Ledoux C,Ziller-Remi C,Paul S,Erbs P,Corvaia N,Von Hoegen P,Balloul JM,Haegel H

Wed Apr 01 00:00:00 EDT 2009

Reprogramming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines.

Laboratory investigation; a journal of technical methods and pathology

Chakravarti A,Rusu D,Flamand N,Borgeat P,Poubelle PE

Thu Oct 01 00:00:00 EDT 2009

Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H

Wed Jul 01 00:00:00 EDT 2009

Increased intracellular, cell surface, and secreted inducible heat shock protein 70 responses are triggered during the monocyte to dendritic cell (DC) transition by cytokines independently of heat stress and infection and may positively regulate DC growth.

Journal of immunology (Baltimore, Md. : 1950)

Martin CA,Kurkowski DL,Valentino AM,Santiago-Schwarz F

Wed Jul 01 00:00:00 EDT 2009

MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells.

Journal of immunology (Baltimore, Md. : 1950)

Qu C,Nguyen VA,Merad M,Randolph GJ

Sun Mar 15 00:00:00 EDT 2009

IL-12-dependent inducible expression of the CD94/NKG2A inhibitory receptor regulates CD94/NKG2C+ NK cell function.

Journal of immunology (Baltimore, Md. : 1950)

Sáez-Borderías A,Romo N,Magri G,Gumá M,Angulo A,López-Botet M

Thu Jan 15 00:00:00 EST 2009

HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection.

Journal of immunology (Baltimore, Md. : 1950)

Fanales-Belasio E,Moretti S,Fiorelli V,Tripiciano A,Pavone Cossut MR,Scoglio A,Collacchi B,Nappi F,Macchia I,Bellino S,Francavilla V,Caputo A,Barillari G,Magnani M,Laguardia ME,Cafaro A,Titti F,Monini P,Ensoli F,Ensoli B

Sun Mar 01 00:00:00 EST 2009

Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation.

Journal of immunology (Baltimore, Md. : 1950)

Geurtsen J,Chedammi S,Mesters J,Cot M,Driessen NN,Sambou T,Kakutani R,Ummels R,Maaskant J,Takata H,Baba O,Terashima T,Bovin N,Vandenbroucke-Grauls CM,Nigou J,Puzo G,Lemassu A,Daffé M,Appelmelk BJ

Thu Oct 15 00:00:00 EDT 2009

Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs.

Journal of immunology (Baltimore, Md. : 1950)

Mittal R,Bulgheresi S,Emami C,Prasadarao NV

Sun Nov 15 00:00:00 EST 2009

Developmental switch of the expression of ion channels in human dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Zsiros E,Kis-Toth K,Hajdu P,Gaspar R,Bielanska J,Felipe A,Rajnavolgyi E,Panyi G

Thu Oct 01 00:00:00 EDT 2009

IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Kurowska-Stolarska M,Stolarski B,Kewin P,Murphy G,Corrigan CJ,Ying S,Pitman N,Mirchandani A,Rana B,van Rooijen N,Shepherd M,McSharry C,McInnes IB,Xu D,Liew FY

Sun Nov 15 00:00:00 EST 2009

C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Fraser DA,Laust AK,Nelson EL,Tenner AJ

Sun Nov 15 00:00:00 EST 2009

AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity.

Journal of immunology (Baltimore, Md. : 1950)

Didierlaurent AM,Morel S,Lockman L,Giannini SL,Bisteau M,Carlsen H,Kielland A,Vosters O,Vanderheyde N,Schiavetti F,Larocque D,Van Mechelen M,Garçon N

Sun Nov 15 00:00:00 EST 2009

Induction of cross-priming of naive CD8+ T lymphocytes by recombinant bacillus Calmette-Guerin that secretes heat shock protein 70-major membrane protein-II fusion protein.

Journal of immunology (Baltimore, Md. : 1950)

Mukai T,Maeda Y,Tamura T,Matsuoka M,Tsukamoto Y,Makino M

Sun Nov 15 00:00:00 EST 2009

1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Széles L,Keresztes G,Töröcsik D,Balajthy Z,Krenács L,Póliska S,Steinmeyer A,Zuegel U,Pruenster M,Rot A,Nagy L

Sun Feb 15 00:00:00 EST 2009

Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

Journal of immunology (Baltimore, Md. : 1950)

Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B

Sat Aug 01 00:00:00 EDT 2009

Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells.

Journal of immunology (Baltimore, Md. : 1950)

Mihrshahi R,Barclay AN,Brown MH

Thu Oct 15 00:00:00 EDT 2009

Dendritic cell anergy results from endotoxemia in severe malnutrition.

Journal of immunology (Baltimore, Md. : 1950)

Hughes SM,Amadi B,Mwiya M,Nkamba H,Tomkins A,Goldblatt D

Sat Aug 15 00:00:00 EDT 2009

Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

Podgrabinska S,Kamalu O,Mayer L,Shimaoka M,Snoeck H,Randolph GJ,Skobe M

Sat Aug 01 00:00:00 EDT 2009

Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: involvement of IL-10 and prostaglandins.

Journal of immunology (Baltimore, Md. : 1950)

Thivierge M,Stankova J,Rola-Pleszczynski M

Sun Nov 15 00:00:00 EST 2009

IL-4R(alpha), a new member that associates with Syk kinase: implication in IL-4-induced human neutrophil functions.

Journal of immunology (Baltimore, Md. : 1950)

Ennaciri J,Girard D

Thu Oct 15 00:00:00 EDT 2009

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.

Journal of immunology (Baltimore, Md. : 1950)

Scutera S,Fraone T,Musso T,Cappello P,Rossi S,Pierobon D,Orinska Z,Paus R,Bulfone-Paus S,Giovarelli M

Tue Sep 01 00:00:00 EDT 2009

IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice.

Journal of immunology (Baltimore, Md. : 1950)

Chen W,Sivaprasad U,Tabata Y,Gibson AM,Stier MT,Finkelman FD,Hershey GK

Tue Dec 15 00:00:00 EST 2009

IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice.

Journal of immunology (Baltimore, Md. : 1950)

Chen W,Sivaprasad U,Tabata Y,Gibson AM,Stier MT,Finkelman FD,Hershey GK

Tue Dec 15 00:00:00 EST 2009

Single nucleotide changes in the human Igamma1 and Igamma4 promoters underlie different transcriptional responses to CD40.

Journal of immunology (Baltimore, Md. : 1950)

Sinquett FL,Dryer RL,Marcelli V,Batheja A,Covey LR

Sun Feb 15 00:00:00 EST 2009

Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.

Journal of neurotrauma

Helmy A,Carpenter KL,Skepper JN,Kirkpatrick PJ,Pickard JD,Hutchinson PJ

Wed Apr 01 00:00:00 EDT 2009

Anthrax edema toxin induces maturation of dendritic cells and enhances chemotaxis towards macrophage inflammatory protein 3beta.

Infection and immunity

Maldonado-Arocho FJ,Bradley KA

Fri May 01 00:00:00 EDT 2009

The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation.

PloS one

Gur-Wahnon D,Borovsky Z,Liebergall M,Rachmilewitz J

Mon Aug 31 00:00:00 EDT 2009

Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS.

Immunome research

Ceppi M,Clavarino G,Gatti E,Schmidt EK,de Gassart A,Blankenship D,Ogola G,Banchereau J,Chaussabel D,Pierre P

Fri Nov 27 00:00:00 EST 2009

Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness.

The Journal of biological chemistry

Ito T,Suzuki S,Kanaji S,Shiraishi H,Ohta S,Arima K,Tanaka G,Tamada T,Honjo E,Garcia KC,Kuroki R,Izuhara K

Fri Sep 04 00:00:00 EDT 2009

Necator americanus infection: a possible cause of altered dendritic cell differentiation and eosinophil profile in chronically infected individuals.

PLoS neglected tropical diseases

Fujiwara RT,Cançado GG,Freitas PA,Santiago HC,Massara CL,Dos Santos Carvalho O,Corrêa-Oliveira R,Geiger SM,Bethony J

Mon Mar 08 00:00:00 EST 2010

Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts.

PloS one

Pilling D,Fan T,Huang D,Kaul B,Gomer RH

Fri Oct 16 00:00:00 EDT 2009

Comparison of the immunomodulatory properties of three probiotic strains of Lactobacilli using complex culture systems: prediction for in vivo efficacy.

PloS one

Mileti E,Matteoli G,Iliev ID,Rescigno M

Wed Sep 16 00:00:00 EDT 2009

The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.

BMC immunology

Brown DP,Jones DC,Anderson KJ,Lapaque N,Buerki RA,Trowsdale J,Allen RL

Tue Oct 27 00:00:00 EDT 2009

Thrombospondin-1-N-terminal domain induces a phagocytic state and thrombospondin-1-C-terminal domain induces a tolerizing phenotype in dendritic cells.

PloS one

Tabib A,Krispin A,Trahtemberg U,Verbovetski I,Lebendiker M,Danieli T,Mevorach D

Mon Aug 31 00:00:00 EDT 2009

Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.

Blood

Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA

Sat Nov 01 00:00:00 EDT 2008

Induction of CD4+ T-cell anergy and apoptosis by activated human B cells.

Blood

Tretter T,Venigalla RK,Eckstein V,Saffrich R,Sertel S,Ho AD,Lorenz HM

Mon Dec 01 00:00:00 EST 2008

Estrogen inhibits dendritic cell maturation to RNA viruses.

Blood

Escribese MM,Kraus T,Rhee E,Fernandez-Sesma A,López CB,Moran TM

Mon Dec 01 00:00:00 EST 2008

Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity.

The Journal of experimental medicine

Junttila IS,Mizukami K,Dickensheets H,Meier-Schellersheim M,Yamane H,Donnelly RP,Paul WE

Mon Oct 27 00:00:00 EDT 2008

Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus.

PLoS pathogens

Phipps-Yonas H,Seto J,Sealfon SC,Moran TM,Fernandez-Sesma A

Wed Oct 01 00:00:00 EDT 2008

Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus.

Arthritis research & therapy

Monrad SU,Rea K,Thacker S,Kaplan MJ

Fri Feb 20 00:00:00 EST 2009

Human plasmacytoid dendritic cells interact with gp96 via CD91 and regulate inflammatory responses.

Journal of immunology (Baltimore, Md. : 1950)

De Filippo A,Binder RJ,Camisaschi C,Beretta V,Arienti F,Villa A,Della Mina P,Parmiani G,Rivoltini L,Castelli C

Sat Nov 01 00:00:00 EDT 2008

Antiviral-activated dendritic cells: a paracrine-induced response state.

Journal of immunology (Baltimore, Md. : 1950)

Bordería AV,Hartmann BM,Fernandez-Sesma A,Moran TM,Sealfon SC

Sat Nov 15 00:00:00 EST 2008

XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma.

Journal of immunology (Baltimore, Md. : 1950)

Nguyen KD,Fohner A,Booker JD,Dong C,Krensky AM,Nadeau KC

Wed Oct 15 00:00:00 EDT 2008

IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.

Journal of immunology (Baltimore, Md. : 1950)

Krutzik SR,Hewison M,Liu PT,Robles JA,Stenger S,Adams JS,Modlin RL

Sat Nov 15 00:00:00 EST 2008

Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5.

Journal of immunology (Baltimore, Md. : 1950)

Gomez FJ,Pilcher-Roberts R,Alborzi A,Newman SL

Sat Nov 15 00:00:00 EST 2008

The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production.

Journal of immunology (Baltimore, Md. : 1950)

Itoh K,Watanabe A,Funami K,Seya T,Matsumoto M

Wed Oct 15 00:00:00 EDT 2008

Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi.

Journal of immunology (Baltimore, Md. : 1950)

Semnani RT,Venugopal PG,Mahapatra L,Skinner JA,Meylan F,Chien D,Dorward DW,Chaussabel D,Siegel RM,Nutman TB

Sat Nov 15 00:00:00 EST 2008

Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress.

Journal of immunology (Baltimore, Md. : 1950)

Ando T,Mimura K,Johansson CC,Hanson MG,Mougiakakos D,Larsson C,Martins da Palma T,Sakurai D,Norell H,Li M,Nishimura MI,Kiessling R

Mon Dec 15 00:00:00 EST 2008

Regulation of alternative macrophage activation by galectin-3.

Journal of immunology (Baltimore, Md. : 1950)

MacKinnon AC,Farnworth SL,Hodkinson PS,Henderson NC,Atkinson KM,Leffler H,Nilsson UJ,Haslett C,Forbes SJ,Sethi T

Fri Feb 15 00:00:00 EST 2008

Dendritic cell differentiation signals induce anti-inflammatory properties in human adult microglia.

Journal of immunology (Baltimore, Md. : 1950)

Lambert C,Desbarats J,Arbour N,Hall JA,Olivier A,Bar-Or A,Antel JP

Mon Dec 15 00:00:00 EST 2008

Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells.

Human gene therapy

Theoret MR,Cohen CJ,Nahvi AV,Ngo LT,Suri KB,Powell DJ,Dudley ME,Morgan RA,Rosenberg SA

Sat Nov 01 00:00:00 EDT 2008

Activin A induces Langerhans cell differentiation in vitro and in human skin explants.

PloS one

Musso T,Scutera S,Vermi W,Daniele R,Fornaro M,Castagnoli C,Alotto D,Ravanini M,Cambieri I,Salogni L,Elia AR,Giovarelli M,Facchetti F,Girolomoni G,Sozzani S

Wed Sep 24 00:00:00 EDT 2008

Genetically programmed differences in epidermal host defense between psoriasis and atopic dermatitis patients.

PloS one

Zeeuwen PL,de Jongh GJ,Rodijk-Olthuis D,Kamsteeg M,Verhoosel RM,van Rossum MM,Hiemstra PS,Schalkwijk J

Wed Jun 04 00:00:00 EDT 2008

HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk.

PloS one

Saïdi H,Melki MT,Gougeon ML

Thu Feb 12 00:00:00 EST 2009

Direct contact of platelets and their released products exert different effects on human dendritic cell maturation.

BMC immunology

Hamzeh-Cognasse H,Cognasse F,Palle S,Chavarin P,Olivier T,Delézay O,Pozzetto B,Garraud O

Thu Sep 25 00:00:00 EDT 2008

A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles.

Blood

Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

Sat Sep 15 00:00:00 EDT 2007

Natural killer cells trigger differentiation of monocytes into dendritic cells.

Blood

Zhang AL,Colmenero P,Purath U,Teixeira de Matos C,Hueber W,Klareskog L,Tarner IH,Engleman EG,Söderström K

Mon Oct 01 00:00:00 EDT 2007

Immune complexes inhibit differentiation, maturation, and function of human monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Laborde EA,Vanzulli S,Beigier-Bompadre M,Isturiz MA,Ruggiero RA,Fourcade MG,Catalan Pellet AC,Sozzani S,Vulcano M

Sun Jul 01 00:00:00 EDT 2007

Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T

Sat Sep 15 00:00:00 EDT 2007

Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Cassatella MA,Pereira-da-Silva G,Tinazzi I,Facchetti F,Scapini P,Calzetti F,Tamassia N,Wei P,Nardelli B,Roschke V,Vecchi A,Mantovani A,Bambara LM,Edwards SW,Carletto A

Fri Jun 01 00:00:00 EDT 2007

Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells.

Blood

Mennechet FJ,Uzé G

Thu Jun 01 00:00:00 EDT 2006

Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells.

Blood

Mennechet FJ,Uzé G

Thu Jun 01 00:00:00 EDT 2006

Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses.

Blood

Della Chiesa M,Romagnani C,Thiel A,Moretta L,Moretta A

Fri Dec 01 00:00:00 EST 2006

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.

Blood

Munitz A,Bachelet I,Eliashar R,Moretta A,Moretta L,Levi-Schaffer F

Wed Mar 01 00:00:00 EST 2006

CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Cappello P,Fraone T,Barberis L,Costa C,Hirsch E,Elia AR,Caorsi C,Musso T,Novelli F,Giovarelli M

Wed Nov 01 00:00:00 EST 2006

NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor.

Blood

Vitale M,Della Chiesa M,Carlomagno S,Pende D,Aricò M,Moretta L,Moretta A

Fri Jul 15 00:00:00 EDT 2005

Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells.

Proceedings of the National Academy of Sciences of the United States of America

Hsieh FH,Sharma P,Gibbons A,Goggans T,Erzurum SC,Haque SJ

Tue Oct 04 00:00:00 EDT 2005

Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.

Journal of immunology (Baltimore, Md. : 1950)

van Beek J,van Meurs M,'t Hart BA,Brok HP,Neal JW,Chatagner A,Harris CL,Omidvar N,Morgan BP,Laman JD,Gasque P

Tue Feb 15 00:00:00 EST 2005

Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant response.

Journal of immunology (Baltimore, Md. : 1950)

Ohtani T,Nakagawa S,Kurosawa M,Mizuashi M,Ozawa M,Aiba S

Tue Feb 15 00:00:00 EST 2005

CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge.

The European respiratory journal

Pilette C,Francis JN,Till SJ,Durham SR

Tue Jun 01 00:00:00 EDT 2004

CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge.

The European respiratory journal

Pilette C,Francis JN,Till SJ,Durham SR

Tue Jun 01 00:00:00 EDT 2004

Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells?

Blood

Della Bella S,Nicola S,Timofeeva I,Villa ML,Santoro A,Berardi AC

Wed Dec 15 00:00:00 EST 2004

Chemokine receptor-mediated delivery directs self-tumor antigen efficiently into the class II processing pathway in vitro and induces protective immunity in vivo.

Blood

Biragyn A,Ruffini PA,Coscia M,Harvey LK,Neelapu SS,Baskar S,Wang JM,Kwak LW

Fri Oct 01 00:00:00 EDT 2004

Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.

Blood

Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M

Thu Jul 01 00:00:00 EDT 2004

Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.

Blood

Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M

Thu Jul 01 00:00:00 EDT 2004

Monocyte derived dendritic cell responses in common variable immunodeficiency.

Clinical and experimental immunology

Scott-Taylor TH,Green MR,Eren E,Webster AD

200-04 was used in Cell Culture to study the function of monocyte derived dendritic cells (MdDC) in 25 patients with common variable immunodeficiency (CVID) to discern the failure of antibody production. DCs from the majority of CVID patients were normal, while 5 patients susceptible and with affected family members expressed abnormally low levels of DR. DCs from many CVID patients had high spontaneous production of IL-8 and lipopolysaccharide stimulation often caused by a reduction in DR expres

Wed Dec 01 00:00:00 EST 2004

Monocyte derived dendritic cell responses in common variable immunodeficiency.

Clinical and experimental immunology

Scott-Taylor TH,Green MR,Eren E,Webster AD

Wed Dec 01 00:00:00 EST 2004

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

Cancer research

Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT

Sat Feb 15 00:00:00 EST 2003

CD1-dependent dendritic cell instruction.

Nature immunology

Vincent MS,Leslie DS,Gumperz JE,Xiong X,Grant EP,Brenner MB

Sun Dec 01 00:00:00 EST 2002

CD1-mediated gamma/delta T cell maturation of dendritic cells.

The Journal of experimental medicine

Leslie DS,Vincent MS,Spada FM,Das H,Sugita M,Morita CT,Brenner MB

Mon Dec 16 00:00:00 EST 2002

Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages.

The Journal of biological chemistry

Wang J,Guan E,Roderiquez G,Calvert V,Alvarez R,Norcross MA

Fri Dec 28 00:00:00 EST 2001

Immune responses to Plasmodium falciparum-merozoite surface protein 1 (MSP1) antigen, II. Induction of parasite-specific immunoglobulin G in unsensitized human B cells after in vitro T-cell priming with MSP119.

Immunology

Garraud O,Diouf A,Holm I,Perraut R,Longacre S

Thu Jul 01 00:00:00 EDT 1999

CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral reservoir.

Journal of virology

Moir S,Lapointe R,Malaspina A,Ostrowski M,Cole CE,Chun TW,Adelsberger J,Baseler M,Hwu P,Fauci AS

Fri Oct 01 00:00:00 EDT 1999

A 135,000 molecular weight plasma membrane glycoprotein involved in fibronectin-mediated cell adhesion. Immunofluorescence localization in normal and RSV-transformed fibroblasts.

Experimental cell research

Giancotti FG,Comoglio PM,Tarone G

Sat Mar 01 00:00:00 EST 1986

Studies of thiamine metabolism in man; thiamine and pyrimidine excretion with special reference to the relationship between injected and excreted thiamine in normal and abnormal subjects.

The Journal of clinical investigation

ALEXANDER B,LANDWEHR G,MITCHELL F

Wed May 01 00:00:00 EDT 1946

Bioinformatics

Protein Aliases: B cell growth factor 1; B-cell stimulatory factor 1; B_cell stimulatory factor 1; Binetrakin; BSF-1; H-IL-4; IL-4; ILN; Interleukin; interleukin 4 variant 2; Interleukin-4; Interleukin4; Lymphocyte stimulatory factor 1; M-IL-4; MGC79402; Pitrakinra

Human IL-4 Recombinant Protein, PeproTech®

Human IL-4 Protein (200-04-20UG) in Functional

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200-04-20UG

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