Product References
Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Luan X,Yang W,Bai X,Li H,Li H,Fan W,Zhang H,Liu W,Sun L
Mon Nov 01 00:00:00 EDT 2021
Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals.
Scientific reports
Eernstman J,Veldhuisen B,Ligthart P,von Lindern M,van der Schoot CE,van den Akker E
Fri Sep 17 00:00:00 EDT 2021
Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia.
Scientific reports
Inano T,Araki M,Morishita S,Imai M,Kihara Y,Okuda M,Yang Y,Ito M,Osaga S,Mano H,Edahiro Y,Ochiai T,Misawa K,Fukuda Y,Ando J,Komatsu N
Mon Sep 06 00:00:00 EDT 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
Tue Jun 08 00:00:00 EDT 2021
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.
Bone research
Schwerd T,Krause F,Twigg SRF,Aschenbrenner D,Chen YH,Borgmeyer U,Müller M,Manrique S,Schumacher N,Wall SA,Jung J,Damm T,Glüer CC,Scheller J,Rose-John S,Jones EY,Laurence A,Wilkie AOM,Schmidt-Arras D,Uhlig HH
Mon Oct 02 00:00:00 EDT 2023
Alteration of immunophenotype of human macrophages and monocytes after exposure to cigarette smoke.
Scientific reports
da Silva CO,Gicquel T,Daniel Y,Bártholo T,Vène E,Loyer P,Pôrto LC,Lagente V,Victoni T
Thu Jul 30 00:00:00 EDT 2020
Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions.
Scientific reports
Saini C,Srivastava RK,Tarique M,Kurra S,Khanna N,Ramesh V,Sharma A
Tue Sep 15 00:00:00 EDT 2020
Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway.
Cell death discovery
Wang ST,Huang SW,Liu KT,Lee TY,Shieh JJ,Wu CY
Tue Sep 26 00:00:00 EDT 2023
Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.
Stem cells translational medicine
Trump LR,Nayak RC,Singh AK,Emberesh S,Wellendorf AM,Lutzko CM,Cancelas JA
Sat Jun 01 00:00:00 EDT 2019
Nasal delivery of Fasudil-modified immune cells exhibits therapeutic potential in experimental autoimmune encephalomyelitis.
CNS neuroscience & therapeutics
Guo SD,Liu CY,Yu JW,Chai Z,Wang Q,Mi XT,Song GB,Li YH,Yang PW,Feng L,Xiao BG,Ma CG
Sat Jun 01 00:00:00 EDT 2019
RORα suppresses interleukin-6-mediated hepatic acute phase response.
Scientific reports
Kim JY,Han YH,Nam MW,Kim HJ,Lee MO
Tue Aug 13 00:00:00 EDT 2019
TAF1 plays a critical role in AML1-ETO driven leukemogenesis.
Nature communications
Xu Y,Man N,Karl D,Martinez C,Liu F,Sun J,Martinez CJ,Martin GM,Beckedorff F,Lai F,Yue J,Roisman A,Greenblatt S,Duffort S,Wang L,Sun X,Figueroa M,Shiekhattar R,Nimer S
Tue Oct 29 00:00:00 EDT 2019
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Nature communications
Minuesa G,Albanese SK,Xie W,Kazansky Y,Worroll D,Chow A,Schurer A,Park SM,Rotsides CZ,Taggart J,Rizzi A,Naden LN,Chou T,Gourkanti S,Cappel D,Passarelli MC,Fairchild L,Adura C,Glickman JF,Schulman J,Famulare C,Patel M,Eibl JK,Ross GM,Bhattacharya S,Tan DS,Leslie CS,Beuming T,Patel DJ,Goldgur Y,Chodera JD,Kharas MG
Wed Jun 19 00:00:00 EDT 2019
Notch-Expanded Murine Hematopoietic Stem and Progenitor Cells Mitigate Death from Lethal Radiation and Convey Immune Tolerance in Mismatched Recipients.
Stem cells translational medicine
Milano F,Merriam F,Nicoud I,Li J,Gooley TA,Heimfeld S,Imren S,Delaney C
Wed Feb 01 00:00:00 EST 2017
Identification of novel genes and networks governing hematopoietic stem cell development.
EMBO reports
Han T,Yang CS,Chang KY,Zhang D,Imam FB,Rana TM
Thu Dec 01 00:00:00 EST 2016
Nitric oxide inhibits hetero-adhesion of cancer cells to endothelial cells: restraining circulating tumor cells from initiating metastatic cascade.
Scientific reports
Lu Y,Yu T,Liang H,Wang J,Xie J,Shao J,Gao Y,Yu S,Chen S,Wang L,Jia L
Tue Mar 11 00:00:00 EDT 2014
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Blood
Klco JM,Spencer DH,Lamprecht TL,Sarkaria SM,Wylie T,Magrini V,Hundal J,Walker J,Varghese N,Erdmann-Gilmore P,Lichti CF,Meyer MR,Townsend RR,Wilson RK,Mardis ER,Ley TJ
Thu Feb 28 00:00:00 EST 2013
SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.
Leukemia
Hansen N,Ågerstam H,Wahlestedt M,Landberg N,Askmyr M,Ehinger M,Rissler M,Lilljebjörn H,Johnels P,Ishiko J,Melo JV,Alexander WS,Bryder D,Järås M,Fioretos T
Tue Jan 01 00:00:00 EST 2013
Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.
PloS one
Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T
Fri Sep 06 00:00:00 EDT 2013
Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation.
The Journal of biological chemistry
Braun DA,Fribourg M,Sealfon SC
Fri Feb 01 00:00:00 EST 2013
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Cell
Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA
Fri Jun 08 00:00:00 EDT 2012
FANCL ubiquitinates β-catenin and enhances its nuclear function.
Blood
Dao KH,Rotelli MD,Petersen CL,Kaech S,Nelson WD,Yates JE,Hanlon Newell AE,Olson SB,Druker BJ,Bagby GC
Thu Jul 12 00:00:00 EDT 2012
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.
Blood
Hodge LS,Ziesmer SC,Yang ZZ,Secreto FJ,Gertz MA,Novak AJ,Ansell SM
Thu Nov 01 00:00:00 EDT 2012
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.
Blood
Will B,Zhou L,Vogler TO,Ben-Neriah S,Schinke C,Tamari R,Yu Y,Bhagat TD,Bhattacharyya S,Barreyro L,Heuck C,Mo Y,Parekh S,McMahon C,Pellagatti A,Boultwood J,Montagna C,Silverman L,Maciejewski J,Greally JM,Ye BH,List AF,Steidl C,Steidl U,Verma A
Thu Sep 06 00:00:00 EDT 2012
Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells.
Blood
Gori JL,Chandrasekaran D,Kowalski JP,Adair JE,Beard BC,D'Souza SL,Kiem HP
Thu Sep 27 00:00:00 EDT 2012
A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.
The Journal of experimental medicine
Kaufmann KB,Gründer A,Hadlich T,Wehrle J,Gothwal M,Bogeska R,Seeger TS,Kayser S,Pham KB,Jutzi JS,Ganzenmüller L,Steinemann D,Schlegelberger B,Wagner JM,Jung M,Will B,Steidl U,Aumann K,Werner M,Günther T,Schüle R,Rambaldi A,Pahl HL
Mon Jan 16 00:00:00 EST 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 EDT 2012
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.
Proceedings of the National Academy of Sciences of the United States of America
Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I
Tue Oct 23 00:00:00 EDT 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F
Tue Oct 02 00:00:00 EDT 2012
The Sin3a repressor complex is a master regulator of STAT transcriptional activity.
Proceedings of the National Academy of Sciences of the United States of America
Icardi L,Mori R,Gesellchen V,Eyckerman S,De Cauwer L,Verhelst J,Vercauteren K,Saelens X,Meuleman P,Leroux-Roels G,De Bosscher K,Boutros M,Tavernier J
Tue Jul 24 00:00:00 EDT 2012
T cell receptor/CARMA1/NF-κB signaling controls T-helper (Th) 17 differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Molinero LL,Cubre A,Mora-Solano C,Wang Y,Alegre ML
Tue Nov 06 00:00:00 EST 2012
GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells.
Oncogene
Joha S,Nugues AL,Hétuin D,Berthon C,Dezitter X,Dauphin V,Mahon FX,Roche-Lestienne C,Preudhomme C,Quesnel B,Idziorek T
Thu Mar 15 00:00:00 EDT 2012
Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression.
Journal of molecular medicine (Berlin, Germany)
Eaton A,Nagy E,Pacault M,Fauconnier J,Bäck M
Mon Oct 01 00:00:00 EDT 2012
Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1.
PloS one
Arcipowski KM,Bishop GA
Mon Jan 14 00:00:00 EST 2013
Generation of virus-free induced pluripotent stem cell clones on a synthetic matrix via a single cell subcloning in the naïve state.
PloS one
Nishishita N,Shikamura M,Takenaka C,Takada N,Fusaki N,Kawamata S
Thu Dec 13 00:00:00 EST 2012
Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.
The Journal of biological chemistry
Khanna-Gupta A,Abayasekara N,Levine M,Sun H,Virgilio M,Nia N,Halene S,Sportoletti P,Jeong JY,Pandolfi PP,Berliner N
Fri Sep 21 00:00:00 EDT 2012
Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts.
PloS one
Steinman RA,Robinson AR,Feghali-Bostwick CA
Tue May 14 00:00:00 EDT 2013
Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo.
PloS one
Waldmeier L,Meyer-Schaller N,Diepenbruck M,Christofori G
Wed Apr 24 00:00:00 EDT 2013
Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis.
PloS one
Lee MJ,Lee JK,Choi JW,Lee CS,Sim JH,Cho CH,Lee KH,Cho IH,Chung MH,Kim HR,Ye SK
Tue Jan 22 00:00:00 EST 2013
DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.
PloS one
Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H
Thu Nov 08 00:00:00 EST 2012
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.
PloS one
Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC
Fri Jun 29 00:00:00 EDT 2012
Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome.
PloS one
Hulsmans M,Geeraert B,De Keyzer D,Mertens A,Lannoo M,Vanaudenaerde B,Hoylaerts M,Benhabilès N,Tsatsanis C,Mathieu C,Holvoet P
Mon Jun 11 00:00:00 EDT 2012
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.
The Journal of biological chemistry
Yang T,Jian W,Luo Y,Fu X,Noguchi C,Bungert J,Huang S,Qiu Y
Fri Nov 23 00:00:00 EST 2012
Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.
PloS one
Tsuda K,Yamanaka K,Kitagawa H,Akeda T,Naka M,Niwa K,Nakanishi T,Kakeda M,Gabazza EC,Mizutani H
Fri Aug 03 00:00:00 EDT 2012
Direct chromatin PCR (DC-PCR): hypotonic conditions allow differentiation of chromatin states during thermal cycling.
PloS one
Vatolin S,Khan SN,Reu FJ
Tue Mar 12 00:00:00 EDT 2013
Neurotensin and CRH interactions augment human mast cell activation.
PloS one
Alysandratos KD,Asadi S,Angelidou A,Zhang B,Sismanopoulos N,Yang H,Critchfield A,Theoharides TC
Thu May 09 00:00:00 EDT 2013
Influenza A virus infection of human respiratory cells induces primary microRNA expression.
The Journal of biological chemistry
Buggele WA,Johnson KE,Horvath CM
Fri Sep 07 00:00:00 EDT 2012
Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion.
PloS one
Sangeetha VM,Kadekar D,Kale VP,Limaye LS
Mon May 14 00:00:00 EDT 2012
Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.
The Journal of biological chemistry
Gao H,Wu X,Sun Y,Zhou S,Silberstein LE,Zhu Z
Fri Aug 24 00:00:00 EDT 2012
Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells.
Blood cancer journal
Dassé E,Volpe G,Walton DS,Wilson N,Del Pozzo W,O'Neill LP,Slany RK,Frampton J,Dumon S
Fri Jun 01 00:00:00 EDT 2012
Proteasome inhibition upregulates Bim and induces caspase-3-dependent apoptosis in human mast cells expressing the Kit D816V mutation.
Cell death & disease
Westerberg CM,Hägglund H,Nilsson G
Thu Nov 15 00:00:00 EST 2012
Baicalin, a natural compound, promotes regulatory T cell differentiation.
BMC complementary and alternative medicine
Yang J,Yang X,Li M
Wed May 16 00:00:00 EDT 2012
Anti-apoptotic BFL-1 is the major effector in activation-induced human mast cell survival.
PloS one
Ekoff M,Lyberg K,Krajewska M,Arvidsson M,Rak S,Reed JC,Harvima I,Nilsson G
Thu Dec 13 00:00:00 EST 2012
Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin.
Journal of neuroinflammation
Asadi S,Theoharides TC
Fri May 04 00:00:00 EDT 2012
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 EDT 2011
BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription.
Blood
Sheng Z,Ma L,Sun JE,Zhu LJ,Green MR
Thu Sep 08 00:00:00 EDT 2011
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
Blood
Jaako P,Flygare J,Olsson K,Quere R,Ehinger M,Henson A,Ellis S,Schambach A,Baum C,Richter J,Larsson J,Bryder D,Karlsson S
Thu Dec 01 00:00:00 EST 2011
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood
Roy D,Sin SH,Damania B,Dittmer DP
Thu Aug 18 00:00:00 EDT 2011
The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Ortner D,Grabher D,Hermann M,Kremmer E,Hofer S,Heufler C
Sat Oct 15 00:00:00 EDT 2011
Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Rådinger M,Smrž D,Metcalfe DD,Gilfillan AM
Thu Dec 01 00:00:00 EST 2011
Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa.
PloS one
Harel E,Rubinstein A,Nissan A,Khazanov E,Nadler Milbauer M,Barenholz Y,Tirosh B
Tue Feb 14 00:00:00 EST 2012
Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
PloS one
Badr G,Lefevre EA,Mohany M
Thu Dec 29 00:00:00 EST 2011
Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
The Journal of biological chemistry
Sarma NJ,Yaseen NR
Fri Nov 11 00:00:00 EST 2011
